Vascular Endothelial Growth Factor Inhibitors

Name	AC	CK
Ginsenosides	18	34
Curcumin	13	23
Resveratrol	4	15
Bilberry	3	13
EGCG (Epigallocatechin gallate)	6	13
Nigella sativa (aka Black Seed)	2	12
Vitamin D	2	12
Cannabinoids	2	11
Thymoquinone	7	11
Delta-tetrahydrocannabinol (THC)	1	10
Tanshinone IIA	10	10
Zataria multiflora	1	10
Melatonin	4	8
Polyphenols	3	8
Anthocyanins	4	7
Apigenin	5	6
Flavonoids	4	6
Vitamin C	5	6
Apple Polyphenols	1	5
Bee Venom	3	5
Black Raspberry	1	5
Ginkgo biloba	3	5
Lactoferrin	4	5
Parthenolide	3	5
Fucoidan	4	4
Genistein	3	4
Gingerol	2	4
Sulforaphane	2	4
Angelica	2	3
Astragaloside	2	3
Berberine	3	3
Beta-Elemene	2	3
Chlorogenic Acid	3	3
Delphinidin	2	3
Honokiol	2	3
Huaier (Trametes robiniophila murr)	2	3
Luteolin	3	3
Palmitoylethanolamide	2	3
Quercetin	2	3
Xanthohumol	2	3
Acai	1	2
Achiote	1	2
Ashwagandha	1	2
Astaxanthin	1	2
Astragalus	1	2
Bamboo	1	2
Banana	1	2
Betaine	1	2
Biochanin A	1	2
Black Pepper	1	2
Black Tea	2	2
Blueberry	2	2
Boswellia	1	2
Broccoli Sprouts	1	2
Burdock	1	2
Camel Milk	1	2
Catechin	1	2
Chlorella (Algae)	1	2
Cinnamon	2	2
Corn: Purple	1	2
Ellagic Acid	1	2
Eriodictyol	1	2
Formononetin	2	2
Fruit Peel	1	2
Fucoxanthin	1	2
Garcinia dulcis	1	2
Garcinia indica	1	2
Geraniol	1	2
Ginger	1	2
Ginseng (Korean)	2	2
Hesperidin	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Liquiritigenin	2	2
Long Pepper	1	2
Lotus	2	2
Lycopene	1	2
MSM (Methylsulfonylmethane)	1	2
Magnolol	1	2
Myricetin	1	2
Nettle	1	2
Nobiletin	1	2
Olive Oil	1	2
Oridonin	1	2
Orthosiphon	1	2
Paeoniflorin	1	2
Palash	1	2
Piceatannol	1	2
Pine Bark Extract	1	2
Pine Needle	1	2
Pomegranate Peel	2	2
Puerarin	2	2
Saccharomyces Boulardii	1	2
Safflower	1	2
Sea buckthorn	1	2
Seaweed	1	2
Shikonin	1	2
Silibinin	1	2
Sophora Flavescens	1	2
Spirulina	1	2
St. Johns Wort	1	2
Syrian rue	2	2
Tetrahydrocurcumin	1	2
Theaflavins	2	2
Thymol	1	2
Tomato	1	2
Triphala	1	2
Turmeric	2	2
Ursolic Acid	2	2
Vitamin B-3 (Niacin)	1	2
Vitexins	1	2
Whey	1	2
White Mulberry	1	2
Barberry	1	1
Benzyl isothiocyanate	1	1
Betulinic acid	1	1
Caffeic acid phenethyl ester	1	1
Cannabidiol	1	1
Carrot	1	1
Celastrol	1	1
Celery	1	1
Chrysin	1	1
Coenzyme Q10	1	1
Crocetin	1	1
Cyanidin 3-glucoside	1	1
D-Limonene	1	1
Dandelion	1	1
Diosgenin	1	1
Fisetin	1	1
Frankincense	1	1
Galbanic Acid	1	1
Grape	1	1
Guggul	1	1
Harmine	1	1
Holy Basil	1	1
Homeopathic Medicine: All	1	1
Hydrangea	1	1
Isoliquiritigenin	1	1
Licorice	1	1
Lychee	1	1
Mulberry	1	1
Oak	1	1
Paeonol	1	1
Peony	1	1
Phloretin	1	1
Phlorotannins	1	1
Piperine	1	1
Proanthocyanidins	1	1
Prunella vulgaris	1	1
Psychedelics:All	1	1
Pterostilbene	1	1
Saffron	1	1
Schisandra	1	1
Silymarin	1	1
Toona sinensis	1	1
Vitamin E	1	1
Wogonin	1	1
Zerumbone	1	1

[+]

CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.May 31, 2021

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Pubmed Data : Inflammopharmacology. 2021 Jun ;29(3):579-593. Epub 2021 May 18. PMID: 34008150

Article Published Date : May 31, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Coenzyme Q10

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Sci Pollut Res Int. 2020 Apr 20. Epub 2020 Apr 20. PMID: 32314290

Article Published Date : Apr 19, 2020

Study Type : Human Study

Additional Links

Substances : Zataria multiflora

Diseases : Chemical Weapon Agent Injury: Sulfur Mustard, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with polycystic ovary syndrome.Mar 27, 2017

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Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Gene Expression Regulation

[+]

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2016 Feb 5 ;245:1-11. Epub 2015 Dec 8. PMID: 26680107

Article Published Date : Feb 04, 2016

Study Type : Animal Study

Additional Links

Substances : Thymol

Diseases : Diabetic Nephropathy, High Fat Diet

Pharmacological Actions : Renoprotective, Vascular Endothelial Growth Factor Inhibitors

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An aqueous extract of Bixa orellana showed anti-inflammatory properties in serotonin-induced acute inflammation.Dec 31, 2012

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Pubmed Data : Biomed Res Int. 2013 ;2013:463145. Epub 2013 Oct 3. PMID: 24224164

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Achiote

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

An immune-modulating diet in combination with chemotherapy prevented cancer cachexia without suppressing chemotherapeutic efficacy.Jul 01, 2015

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Pubmed Data : Nutr Cancer. 2015 Jul 2:1-9. Epub 2015 Jul 2. PMID: 26133950

Bamboo leaf extract could improve wound closure by 28 % at 12 hours and 54 % at 24 hours in mice.Nov 30, 2014

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Pubmed Data : Planta Med. 2014 Dec ;80(18):1678-84. Epub 2014 Oct 15. PMID: 25317773

Article Published Date : Nov 30, 2014

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

Betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes.Jul 31, 2015

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Pubmed Data : Oncotarget. 2015 Jun 8. Epub 2015 Jun 8. PMID: 26116834

Article Published Date : Jun 07, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Leukemia: Chronic myelogenous leukemia (CML)

Pharmacological Actions : Antiproliferative , Apoptotic, MicroRNA modulator, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Exosomes

[+]

Delphinidin is a promising compound to prevent pathologies associated with generation of vascular network in tumorigenesis.Dec 31, 2014

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Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.Jun 30, 2012

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Pubmed Data : Biochem Pharmacol. 2012 Jul 1 ;84(1):88-92. Epub 2012 Mar 30. PMID: 22484312

Article Published Date : Jun 30, 2012

Study Type : Animal Study

Additional Links

Substances : Eriodictyol

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Essential oil of Pinus koraiensis leaves has anti-diabetic potential.Dec 31, 2012

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Pubmed Data : Turk J Med Sci. 2018 Feb 23 ;48(1):178-186. Epub 2018 Feb 23. PMID: 29479981

Article Published Date : Feb 22, 2018

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

[+]

Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.Nov 30, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3465-3477. PMID: 31432702

Article Published Date : Nov 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ligustrazine

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Anti-metastatic, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma.Dec 31, 2015

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Pubmed Data : Sci Rep. 2016 ;6:21731. Epub 2016 Feb 25. PMID: 26911838

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer.Jul 22, 2009

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Pubmed Data : BMC Cancer. 2009 Jul 23 ;9:250. Epub 2009 Jul 23. PMID: 19624862

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Pubmed Data : Am J Chin Med. 2010;38(6):1115-30. PMID: 21061465

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Sophora Flavescens

Diseases : Breast Cancer, Breast Cancer: Metastatic, Cancer Metastasis

Pharmacological Actions : Anti-Angiogenic, Anti-Proliferative, Vascular Endothelial Growth Factor Inhibitors

[+]

Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis.Nov 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mol Nutr Food Res. 2017 04 ;61(4). Epub 2017 Jan 30. PMID: 27921359

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Xanthohumol

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

[+]

Morelloflavone is a potential inhibitor of tumor angiogenesis by targeting the Rho GTPase and ERK signaling pathways.Jan 14, 2009

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Pubmed Data : Cancer Res. 2009 Jan 15 ;69(2):518-25. PMID: 19147565

Pubmed Data : J Surg Res. 2011 Dec ;171(2):e237-46. Epub 2011 Aug 24. PMID: 21962734

Article Published Date : Nov 30, 2011

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Aneurysm: Aortic

Pharmacological Actions : Antioxidants, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Sea buckthorn and St. John's wort oil may be a promising alternative for the treatment of endometriosis.Nov 30, 2016

Pubmed Data : Int J Mol Sci. 2016 Dec 9 ;17(12). Epub 2016 Dec 9. PMID: 27941690

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Vis. 2016 ;22:599-609. Epub 2016 Jun 9. PMID: 27293376

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Pubmed Data : Pharm Biol. 2013 Mar ;51(3):361-8. Epub 2012 Nov 8. PMID: 23137183

Article Published Date : Feb 28, 2013

Study Type : In Vitro Study

Additional Links

Substances : Oak

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

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[+]

Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice.Sep 30, 2008

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Pubmed Data : Cancer Biother Radiopharm. 2008 Oct ;23(5):647-53. PMID: 18999937

Article Published Date : Sep 30, 2008

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-Angiogenic, Chemotherapeutic, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Antiangiogenic phytochemicals and medicinal herbs may have value in the treatment of endometriosis.Jan 01, 2011

Article Published Date : Mar 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Melanoma

Pharmacological Actions : Anti-Angiogenic, Anti-metastatic, Vascular Endothelial Growth Factor Inhibitors

[+]

Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.Mar 14, 2007

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Pubmed Data : Cancer Res. 2007 Mar 15 ;67(6):2816-23. PMID: 17363604

Article Published Date : Mar 14, 2007

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors

[+]

Blueberry inhibits invasion and angiogenesis in chemically induced oral squamous cell carcinogenesis.Jun 18, 2016

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Pubmed Data : J Nutr Biochem. 2016 Jun 19 ;35:37-47. Epub 2016 Jun 19. PMID: 27371785

Article Published Date : Jun 18, 2016

Study Type : In Vitro Study

Additional Links

Substances : Blueberry

Diseases : Oral Cancer, Oral Cancer: Prevention, Squamous cell carcinoma

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anticarcinogenic Agents, MicroRNA modulator, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

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Pubmed Data : J Med Food. 2016 Dec ;19(12):1166-1171. PMID: 27982754

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Celery

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Dose Response, Plant Extracts

[+]

Chemopreventive and antitumor effects of benzyl isothiocynate on liver cancer.Sep 10, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Sep 11 ;108:65-75. Epub 2018 Sep 11. PMID: 30216802

Article Published Date : Sep 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Benzyl isothiocyanate

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Chemopreventive, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

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Pubmed Data : Front Oncol. 2020 ;10:1756. Epub 2020 Sep 10. PMID: 33014864

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Esophageal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, P21 Activation, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Combined apigenin and gefitinib treatment presents an attractive strategy as alternative treatment for the acquired resistance to EGFR-TKIs in NSCLC.Dec 31, 2018

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Pubmed Data : Front Pharmacol. 2019 ;10:260. Epub 2019 Mar 22. PMID: 30967777

Dandelion polysaccharide is a promising anti-cancer drug candidate for treating liver cancer.Dec 31, 2019

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Pubmed Data : Front Pharmacol. 2020 ;11:460. Epub 2020 Apr 8. PMID: 32322211

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Polysaccharides

[+]

Honokiol: a review of its anticancer potential and mechanisms.Dec 21, 2019

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Pubmed Data : Cancers (Basel). 2019 Dec 22 ;12(1). Epub 2019 Dec 22. PMID: 31877856

Article Published Date : Dec 21, 2019

Study Type : Review

Additional Links

Substances : Honokiol

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Chemopreventive, Vascular Endothelial Growth Factor Inhibitors

[+]

Huaier is a potent anti-tumor and immunomodulatory drug, which could inhibit the infiltration of M2-macrophages in breast cancer microenvironment.Dec 31, 2015

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Pubmed Data : Sci Rep. 2016 ;6:20049. Epub 2016 Feb 1. PMID: 26831282

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Huaier (Trametes robiniophila murr)

Diseases : Breast Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Dose Response

[+]

Hydrangenol suppresses VEGF-stimulated angiogenesis.Mar 31, 2019

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Pubmed Data : Anim Cells Syst (Seoul). 2019 Apr ;23(2):72-81. Epub 2019 Feb 14. PMID: 30949393

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Hydrangea

Diseases : Bladder Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Cell cycle arrest, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

In this mini-review, selected flavonoids which are a group of plant polyphenols that are able to regulate angiogenesis in vitro and in vivo systems are discussed.Dec 31, 2014

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Pubmed Data : Mini Rev Med Chem. 2015 ;15(6):479-89. PMID: 25873069

Article Published Date : Dec 31, 2014

Study Type : Review

Additional Links

Substances : Apigenin, EGCG (Epigallocatechin gallate), Luteolin, Quercetin

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

[+]

Low tumor tissue ascorbate levels were associated with high HIF-1 activation and tumor growth.Jul 14, 2010

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Pubmed Data : Cancer Res. 2010 Jul 15 ;70(14):5749-58. Epub 2010 Aug 22. PMID: 20570889

Article Published Date : Jul 14, 2010

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Endometrial Cancer, Vitamin C Deficiency

Pharmacological Actions : Hypoxia-inducible factor-1 (HIF-1) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Luteolin inhibits the metastasis of triple-negative breast cancer cells.Dec 31, 2016

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Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1488-1495. Epub 2018 Sep 4. PMID: 30257366

Article Published Date : Oct 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Lung Cancer, Nicotine/Tobacco Toxicity

Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation, Vascular Endothelial Growth Factor Inhibitors

[+]

Phloretin treatment in prostate cancer cells induces cell growth inhibition and apoptosis.Dec 31, 2019

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Pubmed Data : Am J Chin Med. 2016 ;44(4):835-49. Epub 2016 May 24. PMID: 27222069

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Pubmed Data : PLoS One. 2011 ;6(9):e25011. Epub 2011 Sep 15. PMID: 21949833

Article Published Date : Dec 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Endometriosis

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

[+]

Regressions of breast carcinoma syngraft following treatment with piperine in combination with thymoquinone.Jul 02, 2017

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Pubmed Data : J Int Med Res. 2014 Jun ;42(3):628-40. Epub 2014 Apr 1. PMID: 24691458

Article Published Date : May 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Esophageal Cancer

Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Radiosensitizer, Vascular Endothelial Growth Factor Inhibitors

[+]

Schizandrin B has potent anti-tumor activity and may be a promising traditional Chinese medicine for human lung carcinoma.Dec 31, 2014

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Pubmed Data : Curr Eye Res. 2017 12 ;42(12):1667-1673. Epub 2017 Sep 22. PMID: 28937825

Article Published Date : Jan 11, 2017

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Hypoxia, Macular Degeneration

Pharmacological Actions : Anti-Angiogenic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mar Drugs. 2017 Jun 20 ;15(6). Epub 2017 Jun 20. PMID: 28632184

Article Published Date : Jun 19, 2017

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Osteosarcoma

Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Bone Regeneration

[+]

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Pubmed Data : Pharmacogn Mag. 2018 Jan ;13(Suppl 4):S731-S736. Epub 2018 Jan 31. PMID: 29491625

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Zerumbone

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.May 31, 2021

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Intake of bilberries has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.Dec 31, 2014

Local ice cryotherapy had beneficial effects in human non-septic knee arthritis.Jul 29, 2019

Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.Nov 15, 2016

Resveratrol may improve some outcomes of PCOS patients.Jul 20, 2019

Two months' of treatment with Z. multiflora improved cytokine levels, respiratory symptom, and FEV1 values in sulfur mustard-exposed patients.Apr 19, 2020

Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with polycystic ovary syndrome.Mar 27, 2017

A Black Raspberry extract could prevent the initiation, promotion, and progression of carcinogenesis in the digestive tract and esophagus.Oct 27, 2014

Melatonin has anti-angiogenic effects at different steps of the angiogenic process in SH-SY5Y neuroblastoma cells.Feb 13, 2017

VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.Feb 28, 2015

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

A ashwagandha water extract suppressed the tumor growth of glioma cells.Jul 25, 2015

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis.Mar 31, 2015

A purple corn extract may be a potent therapeutic agent targeting abnormal angiogenesis in diabetic nephropathy leading to kidney failure.Dec 31, 2012

Açaí is a promising novel pharmacological therapeutic treatment for endometriosis.Dec 31, 2015

Administration of thymol afforded remarkable protection against high fat diet induced diabetic nephropathy.Feb 04, 2016

An aqueous extract of Bixa orellana showed anti-inflammatory properties in serotonin-induced acute inflammation.Dec 31, 2012

An immune-modulating diet in combination with chemotherapy prevented cancer cachexia without suppressing chemotherapeutic efficacy.Jul 01, 2015

Anti-angiogenic effect of shikonin in rheumatoid arthritis.May 31, 2020

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Astaxanthin inhibits homocysteine‑induced endothelial cell dysfunction.Apr 11, 2019

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.Dec 31, 2016

Bamboo leaf extract could improve wound closure by 28 % at 12 hours and 54 % at 24 hours in mice.Nov 30, 2014

Betaine may potentially be used to delay the onset of complications associated with diabetic retinopathy via inhibition of retinal neovascularization in patients with diabetes.Jul 31, 2015

Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.Jul 22, 2018

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model). Jan 01, 2011

Camel milk inhibits inflammatory angiogenesis via downregulation of proangiogenic and proinflammatory cytokines in mice.Jun 30, 2014

Crocin and Metformin suppress metastatic breast cancer progression.Apr 29, 2021

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.Sep 07, 2010

Curcumin inhibits lymphangiogenesis in vitro and in vivo, which could contribute to the antimetastatic effects of curcumin.Aug 26, 2015

Curcumin not only inhibits tumor angiogenesis, but also suppresses the production of VEGF in response to hypoxia.Aug 13, 2015

Curcumin treated animals had a significant reduction in tumor growth as measured by the decrease in size of the subcutaneous xenografts compared to untreated animals.Jun 07, 2015

Delphinidin is a promising compound to prevent pathologies associated with generation of vascular network in tumorigenesis.Dec 31, 2014

Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.Jul 04, 2015

Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo.Dec 31, 2018

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

EGCG can be developed into a potential agent for the prevention and treatment of smoking‑associated NSCLC.May 31, 2015

Ellagic acid exerted protective effects against carbon tetrachloride-induced cirrhosis through the inhibition of ROS formation and angiogenesis.Sep 30, 2017

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats.Jun 30, 2012

Essential oil of Pinus koraiensis leaves has anti-diabetic potential.Dec 31, 2012

Extra virgin olive oil modulates vasodilator enzyme level by repairing angiogenesis function in rat model of preeclampsia.Feb 29, 2020

Galangin inhibits epithelial-mesenchymal transition and angiogenesis by downregulating CD44 in glioma.Dec 31, 2018

Genistein mediated upregulation of CHOP impeded C/EBPβ interaction with the IL-6 promoter, thus disturbing the angiogenic microenvironment which inhibited tumor proliferation.May 31, 2015

Geraniol is an attractive candidate for the anti-angiogenic treatment of tumors.Dec 31, 2014

Ginkgo biloba exocarp extracts played the effects of anti-tumor and anti-metastatic depending upon the inhibition of tumor angiogenesis.Nov 03, 2016

Ginsenoside Rg3 nanoparticle may suppress the expression of VEGF, MMP-9 and HIF-1α in Lewis lung cancer mice.Jun 17, 2016

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina.Dec 31, 2009

GinsenosideRg3 can be employed as an early intervention and a combining therapeutic aid to reduce inflammation and hypertrophic scar formation.Dec 31, 2013

Hesperidin as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors.Jun 22, 2015

Honokiol has a significant anti-nociceptive activity through inhibition of anti-inflammatory mediators.Dec 31, 2017

Hyperbaric oxygen therapy could inhibit glioma cell proliferation and inflammatory cell infiltration.Oct 31, 2016

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa.Feb 22, 2018

Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.Nov 30, 2019

Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma.Dec 31, 2015

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer.Jul 22, 2009

Lion's mane has antitumor effects in tumor-bearing mice.Sep 28, 2011

M. alba has protective effect on diabetic retinopathy.Apr 07, 2016

Matrine, one of the main components extracted from a traditional Chinese herb, Sophora flavescens has anti-cancer activity in an experimental model of metastatic breast cancer in mice.Jan 01, 2010

Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis.Nov 30, 2018

Melittin exerts an antitumor effect on non‑small cell lung cancer cells.Aug 31, 2017

Metformin in combination with curcumin inhibits the growth, metastasis and angiogenesis of hepatocellular carcinoma.Aug 18, 2017

Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.Dec 31, 2011

Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol.Dec 31, 2016

Morelloflavone is a potential inhibitor of tumor angiogenesis by targeting the Rho GTPase and ERK signaling pathways.Jan 14, 2009

Musa acuminata lectin protein has promising anticancer potential.Dec 31, 2018

Myricetin could significantly inhibit tumor angiogenesis and has potential as a chemopreventive agent.Jul 01, 2019

Vascular Endothelial Growth Factor Inhibitors

View the Evidence:
254 Abstracts with Vascular Endothelial Growth Factor Inhibitors Research