Andrographolide

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10 Diseases Researched for Andrographolide
NameACCKFocus
Inflammation22Locked
Stroke12Locked
Cancers: All11Locked
Hepatoma11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Parasitic Diseases11Locked
Protozoan Infections11Locked
Pulmonary Fibrosis: Bleomycin-Induced11Locked
Rheumatoid Arthritis11Locked
16 Pharmacological Actions Researched for Andrographolide
NameACCKFocus
Anti-Inflammatory Agents56Locked
Antioxidants23Locked
NF-kappaB Inhibitor23Locked
Apoptotic22Locked
Heme oxygenase-1 up-regulation12Locked
Neuroprotective Agents12Locked
Nrf2 activation12Locked
Anti-Fibrotic11Locked
Antiparasitic Agents11Locked
Antiprotozoal Agents11Locked
Autophagy Inhibitors11Locked
Chemoprotective Agents11Locked
Chemosensitizer11Locked
Chemotherapeutic11Locked
Immunomodulatory11Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor11Locked

View the Evidence:
84 Abstracts with Andrographolide Research

[+]

Andrographolide alleviates acute brain injury. Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Neurosci. 2018 ;12:657. Epub 2018 Sep 20. PMID: 30294256
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Neuroprotective Agents
[+]

Andrographolide ameliorates diabetic cardiomyopathy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:9086747. Epub 2018 Jun 25. PMID: 30046380
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Cardiomyopathy
Pharmacological Actions : Antioxidants, Apoptotic, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation
[+]

Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice .Jun 30, 2021

Pubmed Data : Int Immunopharmacol. 2021 Jul ;96:107808. Epub 2021 May 30. PMID: 34162168
Article Published Date : Jun 30, 2021
Study Type : Transgenic Animal Study
Additional Links
Substances : Andrographolide
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Andrographolide ameliorates rheumatoid arthritis.Oct 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 11 ;20(20). Epub 2019 Oct 11. PMID: 31614480
Article Published Date : Oct 10, 2019
Study Type : Animal Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Lipopolysaccharide-Induced Toxicity, Rheumatoid Arthritis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents
[+]

Andrographolide exerts significant antidepressant-like effects.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Neuropsychopharmacol. 2019 09 1 ;22(9):585-600. PMID: 31181145
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway.Jan 11, 2017

Pubmed Data : Microbes Infect. 2017 12 ;19(12):605-615. Epub 2017 Sep 7. PMID: 28889969
Article Published Date : Jan 11, 2017
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Influenza A
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Andrographolide inhibits oxidized LDL-induced cholesterol accumulation and foam cell formation in macrophages.Dec 31, 2017

Pubmed Data : Am J Chin Med. 2018 ;46(1):87-106. Epub 2018 Jan 3. PMID: 29298513
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Atherosclerosis, Cholesterol: Oxidation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2010 Oct ;161(3):668-79. PMID: 20880404
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Andrographolide prevented type 1 diabetes by maintaining Th1/Th2/Th17 homeostasis.Jul 31, 2013

Pubmed Data : Int Immunopharmacol. 2013 Aug ;16(4):451-6. Epub 2013 May 23. PMID: 23707775
Article Published Date : Jul 31, 2013
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Immunomodulatory, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-2 Downregulation
[+]

Andrographolide prevents high glucose-induced renal tubular cell damage.Jul 08, 2021

Pubmed Data : Phytomedicine. 2021 Jul 9 ;91:153650. Epub 2021 Jul 9. PMID: 34332282
Article Published Date : Jul 08, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Renoprotective
[+]

Andrographolide prevents high-fat diet-induced obesity.Oct 31, 2014

Pubmed Data : J Pharmacol Exp Ther. 2014 Nov ;351(2):474-83. Epub 2014 Sep 9. PMID: 25204338
Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : High Fat Diet, Insulin Resistance, Obesity
Pharmacological Actions : Insulin Sensitizers
Additional Keywords : Anti-Obesity Agents
[+]

Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1.Apr 30, 2013

Pubmed Data : J Biochem Mol Toxicol. 2013 May ;27(5):259-65. Epub 2013 Apr 29. PMID: 23629921
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Lung Injury: Smoke-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation
[+]

Andrographolide, a novel inducer of apelin gene expression.Aug 02, 2021

Pubmed Data : J Ethnopharmacol. 2021 Aug 3 ;280:114487. Epub 2021 Aug 3. PMID: 34352330
Article Published Date : Aug 02, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Hypoglycemia
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Gene Expression Regulation
[+]

Anti-malarial and cytokine-modulating effects of andrographolide in a murine model of malarial infection.Aug 31, 2019

Pubmed Data : Trop Biomed. 2019 Sep 1 ;36(3):776-791. PMID: 33597499
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Malaria
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-4 upregulation
[+]

Effect of two andrographolide derivatives on cellular and rodent models of non-alcoholic fatty liver disease.Oct 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Nov ;95:402-411. Epub 2017 Sep 12. PMID: 28863380
Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization.Aug 12, 2021

Pubmed Data : Toxicol Appl Pharmacol. 2021 Aug 13 ;428:115672. Epub 2021 Aug 13. PMID: 34391754
Article Published Date : Aug 12, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Immunomodulatory
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Protective effect of andrographolide against STZ induced Alzheimer's disease in experimental rats: possible neuromodulation and Aβ (1-42) analysis/Jul 31, 2021

Pubmed Data : Inflammopharmacology. 2021 Aug ;29(4):1157-1168. Epub 2021 Jul 7. PMID: 34235591
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Alzheimer's Disease, Diabetes: Cognitive Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effects of andrographolide against cerebral ischemia‑reperfusion injury in mice.Sep 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2021 Oct ;48(4). Epub 2021 Aug 9. PMID: 34368862
Article Published Date : Sep 30, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Synergetic effect of Andrographis paniculata polysaccharide on diabetic nephropathy with andrographolide.Nov 30, 2012

Pubmed Data : Int J Biol Macromol. 2012 Dec ;51(5):738-42. Epub 2012 Jul 2. PMID: 22766034
Article Published Date : Nov 30, 2012
Study Type : Animal Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Diabetic Nephropathy
Pharmacological Actions : Renoprotective
Additional Keywords : Natural Substance Synergy
[+]

These results suggested that andrographolide improved oxidative stress and schizophrenia-like behaviors.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2021 Sep ;147(1):9-17. Epub 2021 May 24. PMID: 34294378
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Brain: Oxidative Stress, Schizophrenia
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

This review aims to summarize an overview on the neuroprotective effects of andrographolide and exemplifies the essential mechanisms involved.Jul 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jul 27 ;18(8). Epub 2017 Jul 27. PMID: 28749412
Article Published Date : Jul 26, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Andrographolide, Anti-Inflammatory Agents, Antioxidants, stroke
[+]

Activity of andrographolide against chikungunya virus infection.Sep 17, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 Sep 18 ;5:14179. Epub 2015 Sep 18. PMID: 26384169
Article Published Date : Sep 17, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Chikungunya Virus
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
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An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide.Feb 06, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 Feb 7 ;15:18. Epub 2015 Feb 7. PMID: 25888070
Article Published Date : Feb 06, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide, Chlorogenic Acid, Flavonoids
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Andrographis paniculata downregulates proinflammatory cytokine production and augments cell mediated immune response in metastatic tumors.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2010 ;11(3):723-9. PMID: 21039043
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Cancer Metastasis, Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Andrographolide - A prospective remedy for chikungunya fever and viral arthritis.Aug 11, 2021

Pubmed Data : Int Immunopharmacol. 2021 Aug 12 ;99:108045. Epub 2021 Aug 12. PMID: 34435582
Article Published Date : Aug 11, 2021
Study Type : Review
Additional Links
Substances : Andrographolide
Diseases : Arthritis, Chikungunya Virus
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Antiviral Agents, Immunomodulatory
[+]

Andrographolide augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells.Dec 31, 2017

Pubmed Data : Toxicol Appl Pharmacol. 2018 12 1 ;360:120-130. Epub 2018 Oct 4. PMID: 30291937
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Inflammation, Oxidative Stress, Smoking
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation
[+]

Andrographolide can benefit the treatment of vascular inflammatory diseases.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2014 ;2014:130381. Epub 2014 Jul 10. PMID: 25114952
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Cardiovascular Diseases, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Andrographolide can reduce bleomycin-induced pulmonary fibrosis.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2021 May ;9(9):764. PMID: 34268377
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Andrographolide could bind with TNF and NFkB1 proteins, block TNF-induced cytokine storm in COVID-19 patients.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2021;12:648250. Epub 2021 Jun 24. PMID: 34248936
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Cytokine Modulation, Cytokine Storm
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Andrographolide demonstrated antiproliferative and apoptotic properties.Dec 31, 2019

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2020 ;20(6):930-942. PMID: 31774047
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel
[+]

Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells.Jan 31, 2011

Pubmed Data : Toxicol Appl Pharmacol. 2011 Feb 1 ;250(3):336-45. Epub 2010 Dec 4. PMID: 21134392
Article Published Date : Jan 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.Jan 14, 2014

Pubmed Data : Biochem Pharmacol. 2014 Jan 15 ;87(2):229-42. Epub 2013 Oct 24. PMID: 24161787
Article Published Date : Jan 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
[+]

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2017 ;11:3333-3341. Epub 2017 Nov 23. PMID: 29200829
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells.Jul 06, 2017

Pubmed Data : Anticancer Drugs. 2017 Jul 7. Epub 2017 Jul 7. PMID: 28692436
Article Published Date : Jul 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Lung Cancer
Pharmacological Actions : Autophagy Inhibitors, Chemosensitizer, Chemotherapeutic
Additional Keywords : Andrographolidem, Autophagy Inhibitors, Chemosensitizer, Chemotherapeutic Synergy: Cisplatin, lung cancer
[+]

Andrographolide exerts anti-hepatitis C virus activity.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2014 Jan ;171(1):237-52. PMID: 24117426
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Hepatitis C
Pharmacological Actions : Antioxidants, Antiviral Agents, Heme oxygenase-1 up-regulation
[+]

Andrographolide from the A. paniculata possess anti-dengue activity against dengue-2 virus.Feb 28, 2021

Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113541. Epub 2020 Nov 2. PMID: 33152438
Article Published Date : Feb 28, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Dengue
Pharmacological Actions : Antiviral Agents, Enzyme Inhibitors
Additional Keywords : Plant Extracts
[+]

Andrographolide has an antitumor effect and can significantly affect glycolysis in ATC cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:5526581. Epub 2021 Jul 14. PMID: 34335811
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Thyroid Cancer
Pharmacological Actions : Apoptotic
[+]

Andrographolide has the potential to inhibit neuraminidase activity of H1N1.Aug 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Dis. 2014 Sep ;4:S624-S630. Epub 2014 Oct 6. PMID: 32289026
Article Published Date : Aug 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Influenza
Pharmacological Actions : Antiviral Agents
[+]

Andrographolide induces apoptosis in gastric cancer cells through reactivation of p53 and inhibition of Mdm-2.Aug 31, 2021

Pubmed Data : Dokl Biochem Biophys. 2021 Sep ;500(1):393-401. Epub 2021 Oct 25. PMID: 34697748
Article Published Date : Aug 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells.Apr 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 May ;13(5):3837-3844. Epub 2017 Mar 27. PMID: 28529596
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
[+]

Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.Oct 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2012 Nov ;33(11):2190-8. Epub 2012 Aug 6. PMID: 22869602
Article Published Date : Oct 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
[+]

Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.Jan 31, 2012

Pubmed Data : Cell Biol Toxicol. 2012 Feb ;28(1):47-56. Epub 2011 Oct 20. PMID: 22012578
Article Published Date : Jan 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
[+]

Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK.Sep 22, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2016 Sep 23 ;13(1):251. Epub 2016 Sep 23. PMID: 27663973
Article Published Date : Sep 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Andrographolide induces oxidative stress-dependent cell death in unicellular protozoan parasite Trypanosoma brucei.Jul 20, 2017

Pubmed Data : Acta Trop. 2017 Jul 21 ;176:58-67. Epub 2017 Jul 21. PMID: 28739368
Article Published Date : Jul 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Parasitic Diseases, Protozoan Infections
Pharmacological Actions : Antiparasitic Agents, Antiprotozoal Agents
Additional Keywords : Andrographolide, Antiparasitic Agents, Antiprotozoal Agents, Parasitic Diseases, Protozoan Infections
[+]

Andrographolide inhibits inflammatory cytokines secretion in LPS-stimulated RAW264.7 cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:8248142. Epub 2017 Jun 5. PMID: 28676833
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation.Sep 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Dent Res. 2011 Oct ;90(10):1246-52. Epub 2011 Aug 12. PMID: 21841043
Article Published Date : Sep 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Chemopreventive, NF-kappaB Inhibitor
[+]

Andrographolide inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line.Dec 31, 2017

Pubmed Data : Pharmazie. 2018 10 1 ;73(10):594-597. PMID: 30223924
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells.Mar 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Apr ;15(4):5301-5305. Epub 2018 Feb 2. PMID: 29552170
Article Published Date : Mar 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes.Aug 31, 2015

Pubmed Data : Life Sci. 2015 Sep 1 ;136:67-72. Epub 2015 Jul 2. PMID: 26141990
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Andrographolide is a potent inhibitor of breast cancer-induced bone metastasis.Jan 31, 2014

Pubmed Data : Breast Cancer Res Treat. 2014 Feb ;144(1):33-45. Epub 2014 Jan 31. PMID: 24481680
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Breast Cancer
Pharmacological Actions : Osteoprotective
[+]

Andrographolide is an alternative treatment to overcome resistance in ER-positive breast cancer.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Malays J Med Sci. 2019 Sep ;26(5):6-20. Epub 2019 Nov 4. PMID: 31728115
Article Published Date : Aug 31, 2019
Study Type : Review
Additional Links
Substances : Andrographolide
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
[+]

Andrographolide is cytotoxic to human liver cancer cells. Aug 01, 2011

Pubmed Data : Mol Carcinog. 2011 Aug ;50(8):580-91. Epub 2011 Feb 11. PMID: 21319226
Article Published Date : Aug 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
[+]

Andrographolide may offer a pharmacological therapy to slow disease progression in patients with small aneurysms.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2016 Jan ;356(1):137-47. Epub 2015 Oct 19. PMID: 26483397
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Aneurysm: Aortic
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Andrographolide might be useful as a treatment for various inflammatory diseases.Jul 21, 2017

Pubmed Data : Inflammopharmacology. 2017 Jul 22. Epub 2017 Jul 22. PMID: 28735448
Article Published Date : Jul 21, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Inflammation, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Andrographolide, Anti-Inflammatory Agents, Inflammation, rheumatoid arthritis
[+]

Andrographolide nanoparticles in leishmaniasis: characterization and in vitro evaluations.Dec 08, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Nanomedicine. 2010 Dec 9 ;5:1113-21. Epub 2010 Dec 9. PMID: 21270962
Article Published Date : Dec 08, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Leishmaniasis
Pharmacological Actions : Leishmanicidal
[+]

Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Manag Res. 2018 ;10:1079-1088. Epub 2018 May 10. PMID: 29785137
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Andrographolide presents therapeutic effect on ulcerative colitis through the inhibition of IL-23/IL-17 axis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2018 ;10(2):465-473. Epub 2018 Feb 15. PMID: 29511440
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Andrographolide prevents EV-D68 replication by inhibiting the acidification of virus-containing endocytic vesicles.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2018 ;9:2407. Epub 2018 Oct 8. PMID: 30349523
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Enterovirus
Pharmacological Actions : Antiviral Agents
[+]

Andrographolide protects liver cells from H2O2 induced cell death.Jan 10, 2016

Pubmed Data : Biochim Biophys Acta. 2016 11 ;1860(11 Pt A):2377-2390. Epub 2016 Jul 11. PMID: 27418236
Article Published Date : Jan 10, 2016
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Hydrogen Peroxide Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

Andrographolide protects PC12 cells against β-amyloid-induced autophagy-associated cell death.Sep 18, 2018

Pubmed Data : Int J Mol Sci. 2018 Sep 19 ;19(9). Epub 2018 Sep 19. PMID: 30235892
Article Published Date : Sep 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Andrographolide sensitized bladder cancer cells to TRAIL-mediated apoptosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Biol Sci. 2019 ;15(3):688-700. Epub 2019 Jan 24. PMID: 30745855
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Andrographolide sulfonate is a promising treatment to combat methicillin-resistant Staphylococcus aureus.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:720685. Epub 2021 Sep 16. PMID: 34603031
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Methicillin-resistant Staphylococcus aureus
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation
[+]

Andrographolide treatment mitigated the gut-brain-axis associated pathology in Gulf War Illness.Jul 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Sci. 2021 Jul 9 ;11(7). Epub 2021 Jul 9. PMID: 34356139
Article Published Date : Jul 08, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Gulf War Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Gut-brain Axis
[+]

Andrographolide, a new hope in the prevention and treatment of metabolic syndrome.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:571. Epub 2017 Aug 23. PMID: 28878680
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Cardiovascular Diseases, Metabolic Syndrome X
Pharmacological Actions : Antihypertensive Agents, Hypolipidemic
[+]

Andrographolide, an antioxidant, counteracts paraquat- induced mutagenesis in mammalian cells.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2021 Feb 1 ;22(S1):3-8. Epub 2021 Feb 1. PMID: 33576206
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Paraquat Toxicity
Pharmacological Actions : Antimutagenic Agents, Antioxidants
Problem Substances : Paraquat
[+]

Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2'-N-acetyltransferase in Mycobacterium tuberculosis.Aug 31, 2015

Pubmed Data : J Mol Graph Model. 2015 Sep ;61:133-40. Epub 2015 Jul 21. PMID: 26245695
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Mycobacterium Tuberculosis
Pharmacological Actions : Anti-Bacterial Agents, Enzyme Inhibitors
Additional Keywords : Plant Extracts
[+]

Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines.Sep 30, 2013

Pubmed Data : Anticancer Res. 2013 Oct ;33(10):4365-71. PMID: 24123004
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Ovarian Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Anti-SARS-CoV-2 activity of Andrographis paniculata extract.Jan 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nat Prod. 2021 04 23 ;84(4):1261-1270. Epub 2021 Apr 12. PMID: 33844528
Article Published Date : Jan 22, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Hepatoprotective, Neuroprotective Agents, Renoprotective
Additional Keywords : Plant Extracts
[+]

Anticancer potential of andrographolide from Andrographis paniculata.May 22, 2021

Pubmed Data : J Ethnopharmacol. 2021 May 23 ;272:113936. Epub 2021 Feb 18. PMID: 33610710
Article Published Date : May 22, 2021
Study Type : Review
Additional Links
Substances : Andrographolide
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

AP-1/IRF-3 targeted anti-inflammatory activity of andrographolide isolated from Andrographis paniculata.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:210736. Epub 2013 Jun 6. PMID: 23840248
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line.Apr 15, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2016 Apr 16 ;23:40. Epub 2016 Apr 16. PMID: 27084510
Article Published Date : Apr 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Docking results showed very strong affinity of andrographolide to RBD and NSP12 of the SARS-CoV-2 virus.Jul 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Genet Eng Biotechnol. 2021 Jul 13 ;19(1):101. Epub 2021 Jul 13. PMID: 34255214
Article Published Date : Jul 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory
[+]

Enhanced protective activity of nano formulated andrographolide against arsenic induced liver damage.Dec 04, 2015

Pubmed Data : Chem Biol Interact. 2015 Dec 5 ;242:281-9. Epub 2015 Oct 17. PMID: 26485141
Article Published Date : Dec 04, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Arsenic
[+]

Evaluating andrographolide as a potent inhibitor of NS3-4A protease and its drug-resistant mutants.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Virol. 2015 ;2015:972067. Epub 2015 Oct 26. PMID: 26587022
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
[+]

Evaluation of anti-bacterial and anti-oxidant potential of andrographolide and echiodinin.Jul 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Biomed. 2013 Aug ;3(8):604-10; discussion 609-10. PMID: 23905016
Article Published Date : Jul 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Bacillus subtilis infections, Escherichia coli Infections, Klebsiella Infections, Mycobacterium Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection, Streptococcus Infections
Pharmacological Actions : Anti-Bacterial Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells.Jul 13, 2010

Pubmed Data : J Agric Food Chem. 2010 Jul 14 ;58(13):7641-8. PMID: 20536138
Article Published Date : Jul 13, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Promyelocytic leukemia
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Intracellular glutathione regulates andrographolide-induced cytotoxicity on hepatoma cells.Jan 01, 2009

Pubmed Data : Redox Rep. 2009 ;14(4):176-84. PMID: 19695125
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Hepatoma
Pharmacological Actions : Antioxidants, Apoptotic
[+]

Nanoemulsomes for enhanced oral bioavailability of the anticancer phytochemical andrographolide: characterization and pharmacokinetics.Oct 05, 2021

Pubmed Data : AAPS PharmSciTech. 2021 Oct 6 ;22(7):246. Epub 2021 Oct 6. PMID: 34617166
Article Published Date : Oct 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

Protective mechanism of andrographolide against carbon tetrachloride-induced acute liver injury in mice.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2011 ;34(11):1666-70. PMID: 22040877
Article Published Date : Dec 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The present findings implicate the promising clinical applications of Andrographolide on cervical cancer treatment.Feb 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 Feb 7 ;12(2). Epub 2020 Feb 7. PMID: 32046125
Article Published Date : Feb 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
[+]

The present review supports that targeting chronic inflammation may have a broad application prospect for the prevention and treatment of cancer.May 31, 2017

Pubmed Data : Sci China Life Sci. 2017 Jun ;60(6):601-616. Epub 2017 May 29. PMID: 28639101
Article Published Date : May 31, 2017
Study Type : Review
Additional Links
Substances : Andrographolide, Curcumin, Green Tea
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Andrographolide, Anti-Inflammatory Agents, Cancers: All, CURCUMIN, GREEN TEA, Inflammation
[+]

The present review will give an overview of widely investigated plant-derived compounds which have exhibited potent effects on cellular and humoral immune functions.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Plant Sci. 2015 ;6:655. Epub 2015 Aug 25. PMID: 26379683
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Andrographolide, Capsaicin, Curcumin, EGCG (Epigallocatechin gallate), Genistein, Quercetin, Resveratrol
Pharmacological Actions : Immunomodulatory
[+]

The prowess of andrographolide as a natural weapon in the war against cancer.Jan 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 08 4 ;12(8). Epub 2020 Aug 4. PMID: 32759728
Article Published Date : Jan 03, 2020
Study Type : Review
Additional Links
Substances : Andrographolide
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

These may indicate the application of andrographolide for therapeutic use in equine degenerative joint diseases.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Sch Res Notices. 2014 ;2014:464136. Epub 2014 Oct 29. PMID: 27379277
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Degenerative Joint Disease
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor

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