Biochanin A

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8 Diseases Researched for Biochanin A
NameACCKFocus
Breast Cancer33Locked
Cancers: Multi-Drug Resistant22Locked
Hypothyroidism12Locked
Low Testosterone12Locked
Clostridium Infections11Locked
DNA damage11Locked
Estrogen Dominance11Locked
Stomach Cancer11Locked
9 Pharmacological Actions Researched for Biochanin A
NameACCKFocus
Secretagogue12Locked
Steroidogenesis12Locked
Anti-Bacterial Agents11Locked
Antineoplastic Agents11Locked
Antiproliferative 11Locked
Apoptotic11Locked
Aromatase Inhibitors11Locked
Chemosensitizer11Locked
Phase II Detoxification Enzyme Inducer11Locked

View the Evidence:
75 Abstracts with Biochanin A Research

[+]

An herbal extract combination (Biochanin A, Acetyl tetrapeptide-3, and ginseng extracts) versus 3% minoxidil solution for the treatment of androgenetic alopecia.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Aesthet Dermatol. 2020 Oct ;13(10):32-37. Epub 2020 Oct 1. PMID: 33584955
Article Published Date : Sep 30, 2020
Study Type : Human Study
Additional Links
Substances : Biochanin A, Ginseng
Diseases : Alopecia: Androgenic
Pharmacological Actions : Regenerative
Additional Keywords : Hair Regeneration, Natural Substances Versus Drugs
[+]

Biochanin A from red clover inhibits melanogenesis and may be helpful for hyperpigmentation disorders.Jan 01, 2011

Pubmed Data : Biosci Biotechnol Biochem. 2011 ;75(5):914-8. Epub 2011 May 20. PMID: 21597196
Article Published Date : Jan 01, 2011
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Biochanin A, Genistein, Red Clover
Diseases : Hyperpigmentation
[+]

The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2020 ;20:371. Epub 2020 Aug 5. PMID: 32774165
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Natural Substance/Drug Synergy
[+]

Administration of biochanin A can improve and postpone retinopathy.Nov 30, 2018

Pubmed Data : Can J Diabetes. 2018 Dec ;42(6):639-644. Epub 2018 Apr 3. PMID: 30054234
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Amelioration of PM 2.5-induced lung toxicity in rats by nutritional supplementation with biochanin A.Sep 30, 2020

Pubmed Data : Ecotoxicol Environ Saf. 2020 Oct 1 ;202:110878. Epub 2020 Jun 22. PMID: 32585486
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antiobesity effect of Biochanin-A: Effect on trace element metabolism in high fat diet-induced obesity.Feb 05, 2020

Pubmed Data : Cardiovasc Hematol Agents Med Chem. 2020 Feb 6. Epub 2020 Feb 6. PMID: 32031077
Article Published Date : Feb 05, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : High Fat Diet, Insulin Resistance, Obesity
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin.Mar 14, 2021

Pubmed Data : Drug Chem Toxicol. 2021 Mar 15:1-12. Epub 2021 Mar 15. PMID: 33719799
Article Published Date : Mar 14, 2021
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Hypolipidemic, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A alleviates gingival inflammation and alveolar bone loss in rats with experimental periodontitis.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Dec ;20(6):251. Epub 2020 Oct 23. PMID: 33178349
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A ameliorates arsenic-induced hepato- and hematotoxicity in rats.Jan 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Jan 9 ;21(1):69. Epub 2016 Jan 9. PMID: 26760991
Article Published Date : Jan 08, 2016
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Arsenic Poisoning, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Superoxide Dismutase Up-regulation
Problem Substances : Arsenic
[+]

Biochanin A ameliorates histological changes of renal and cutaneous tissue related to ovariectomy and/or anastrozole treatment.May 15, 2018

Pubmed Data : Life Sci. 2018 May 15 ;201:9-16. Epub 2018 Mar 19. PMID: 29567078
Article Published Date : May 15, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Genistein, Red Clover
Diseases : Menopausal Syndrome
Pharmacological Actions : Antioxidants
Additional Keywords : Ovariectomy-Induced Changes
[+]

Biochanin A ameliorates ovalbumin-induced airway inflammation.May 01, 2020

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2020 May 2. Epub 2020 May 2. PMID: 32359341
Article Published Date : May 01, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
[+]

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Cir Bras. 2019 ;34(11):e201901104. Epub 2019 Dec 20. PMID: 31859817
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway.Jan 19, 2021

Pubmed Data : Arch Physiol Biochem. 2021 Jan 20:1-16. Epub 2021 Jan 20. PMID: 33471570
Article Published Date : Jan 19, 2021
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Cardiomyopathy, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Biochanin A attenuates ovariectomy-induced cognition deficit.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:603316. Epub 2021 Mar 16. PMID: 33815102
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Postmenopausal Disorders: Memory Impairment
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Ovariectomy-Induced Changes
[+]

Biochanin A attenuates zymosan-induced arthritis in mice similarly to 17-β estradiol.Nov 30, 2020

Pubmed Data : Inflamm Res. 2020 Dec ;69(12):1245-1256. Epub 2020 Sep 25. PMID: 32975609
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Arthritis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-4 upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Ovariectomy-Induced Changes
[+]

Biochanin A can improve insulin sensitivity by activating insulin signalling.Sep 28, 2020

Pubmed Data : Arch Physiol Biochem. 2020 Sep 29:1-7. Epub 2020 Sep 29. PMID: 32990040
Article Published Date : Sep 28, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : High Fat Diet, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Biochanin A exerts protective effects on lipopolysaccharide-induced Parkinson's disease.Jan 09, 2016

Pubmed Data : Neurotox Res. 2016 10 ;30(3):486-98. Epub 2016 Jul 14. PMID: 27417698
Article Published Date : Jan 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Lipopolysaccharide-Induced Toxicity, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A has been shown to have neuroprotective effects in cerebral ischemia/reperfusion.Jan 14, 2015

Pubmed Data : J Neurol Sci. 2015 Jan 15 ;348(1-2):121-5. Epub 2014 Nov 18. PMID: 25466482
Article Published Date : Jan 14, 2015
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Brain Inflammation , Brain Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A has gastroprotective effects in ethanol-induced gastric mucosal ulceration.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(3):e0121529. Epub 2015 Mar 26. PMID: 25811625
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Antioxidants, Gastroprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Biochanin A has potential antihyperglycemic activity.Feb 14, 2012

Pubmed Data : Eur J Pharmacol. 2012 Feb 15 ;676(1-3):89-94. Epub 2011 Dec 8. PMID: 22178203
Article Published Date : Feb 14, 2012
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet-induced obesity. Dec 31, 2015

Pubmed Data : Mol Nutr Food Res. 2016 09 ;60(9):1944-55. Epub 2016 Jun 8. PMID: 27145114
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Insulin Resistance, Obesity
Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents, Hypolipidemic
[+]

Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:1119-1127. Epub 2018 Aug 27. PMID: 30257324
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Diabetes Mellitus: Type 2, Hyperglycemia, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Insulin Sensitizers, SIRT1 Activator
[+]

Biochanin A protect against lipopolysaccharide-induced acute lung injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microb Pathog. 2020 Jan ;138:103846. Epub 2019 Nov 4. PMID: 31698051
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A protected the brain against ischemic injury in rats by anti-oxidative and anti-inflammatory actions.Nov 25, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2019 Nov 26 ;25:8975-8983. Epub 2019 Nov 26. PMID: 31767824
Article Published Date : Nov 25, 2019
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons.Jan 11, 2019

Pubmed Data : Behav Pharmacol. 2019 12 ;30(8):700-711. PMID: 31703032
Article Published Date : Jan 11, 2019
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Brain Inflammation , Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury.Aug 31, 2016

Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:324-31. Epub 2016 Jun 23. PMID: 27344638
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin A reduces inflammatory injury and neuronal apoptosis following subarachnoid hemorrhage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Behav Neurol. 2018 ;2018:1960106. Epub 2018 Jun 3. PMID: 29971136
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Brain Inflammation , Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.Jul 22, 2018

Pubmed Data : Oncol Res. 2018 Jul 23. Epub 2018 Jul 23. PMID: 30037363
Article Published Date : Jul 22, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2020 Aug 1 ;78:153298. Epub 2020 Aug 1. PMID: 32781391
Article Published Date : Jul 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Biochanin-A attenuates neuropathic pain in diabetic rats.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2016 Oct - Dec;7(4):231-237. Epub 2016 Nov 25. PMID: 27890700
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Diabetic Neuropathy
Pharmacological Actions : Analgesics
[+]

Formononetin and biochanin A protects against ritonavir induced hepatotoxicity.Nov 14, 2018

Pubmed Data : Life Sci. 2018 Nov 15 ;213:174-182. Epub 2018 Oct 13. PMID: 30326221
Article Published Date : Nov 14, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Formononetin
Diseases : HIV Protease Inhibitor Ritonavir Toxicity, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor
[+]

Phytoestrogens can stimulate testosterone synthesis during puberty in male goats by increasing the secretion of T3; a hormone known to stimulate Leydig cell steroidogenesis.Dec 10, 2009

Pubmed Data : Acta Vet Scand. 2009 Dec 10;51:51. PMID: 20003293
Article Published Date : Dec 10, 2009
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, phytoestrogens
Diseases : Hypothyroidism, Low Testosterone
Pharmacological Actions : Secretagogue, Steroidogenesis
[+]

Protective effects of biochanin A on articular cartilage.Nov 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 Nov 15 ;14:444. Epub 2014 Nov 15. PMID: 25398247
Article Published Date : Nov 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

red clover extract and biochanin A or formononetin significantly ameliorate the lipid profiles of STZ-diabetic mice.May 31, 2012

Pubmed Data : Phytother Res. 2012 Jun ;26(6):860-4. Epub 2011 Nov 14. PMID: 22084061
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Formononetin, Red Clover
Diseases : Diabetes Mellitus: Type 2, Dyslipidemias
Pharmacological Actions : Hypolipidemic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

The protective effect of biochanin A against rotenone-induced neurotoxicit.Nov 30, 2020

Pubmed Data : Ecotoxicol Environ Saf. 2020 Dec 1 ;205:111344. Epub 2020 Sep 22. PMID: 32977283
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Brain: Oxidative Stress, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Problem Substances : Rotenone
[+]

The results suggest biochanin A as a nephroprotective agent against cisplatin toxicity.Jul 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Aug ;61:8-19. Epub 2018 May 21. PMID: 29793166
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

Therapeutic effects of biochanin A, phloretin, and epigallocatechin-3-gallate in reducing oxidative stress in arsenic-intoxicated mice.Jan 05, 2021

Pubmed Data : Environ Sci Pollut Res Int. 2021 Jan 6. Epub 2021 Jan 6. PMID: 33410021
Article Published Date : Jan 05, 2021
Study Type : Animal Study
Additional Links
Substances : Biochanin A, EGCG (Epigallocatechin gallate), Phloretin
Diseases : Arsenic Poisoning, Oxidative Stress
Pharmacological Actions : Antioxidants
Problem Substances : Arsenic
[+]

Anti-proliferative activity of biochanin A in human osteosarcoma cells via mitochondrial-involved apoptosis.Jan 31, 2018

Pubmed Data : Food Chem Toxicol. 2018 Feb ;112:194-204. Epub 2018 Jan 3. PMID: 29305928
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
Additional Keywords : Plant Extracts
[+]

Antiproliferative activity of combined biochanin A and ginsenoside Rh2 on MDA-MB-231 and MCF-7 human breast cancer cells.Nov 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 8 ;23(11). Epub 2018 Nov 8. PMID: 30413008
Article Published Date : Nov 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Ginsenosides
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Natural Substance Synergy
[+]

Biochanin A alleviates oxidative damage caused by the urban particulate matter.Mar 14, 2021

Pubmed Data : Food Funct. 2021 Mar 15 ;12(5):1958-1972. PMID: 33496707
Article Published Date : Mar 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Air Pollution Linked Toxicity, Lung Injury: Acute, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Biochanin A attenuates LPS-induced pro-inflammatory responses and inhibits the activation of the MAPK pathway in BV2 microglial cells.Jan 31, 2015

Pubmed Data : Int J Mol Med. 2015 Feb ;35(2):391-8. Epub 2014 Dec 2. PMID: 25483920
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anticarcinogenic Agents, Interleukin-1 beta downregulation
[+]

Biochanin A can selectively target cancer cells and inhibit multiple signaling pathways in HER-2-positive breast cancer cells.Dec 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Oncol. 2009 ;2009:121458. Epub 2010 Feb 11. PMID: 20169097
Article Published Date : Dec 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Selective Cytotoxicity
[+]

Biochanin A enhances the radiotoxicity in colon tumor cells in vitro.Dec 31, 2012

Pubmed Data : J Environ Pathol Toxicol Oncol. 2013 ;32(3):189-203. PMID: 24266406
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Radiosensitizer
[+]

Biochanin A has anti-inflammatory, estrogen-like, and glucose and lipid metabolism modulatory activity, as well as cancer preventive and neuroprotective effects.Jan 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:793. Epub 2019 Jul 12. PMID: 31354500
Article Published Date : Jan 01, 2019
Study Type : Review
Additional Links
Substances : Biochanin A
Pharmacological Actions : Anti-cancer, Anti-Inflammatory Agents, Hypolipidemic, Neuroprotective Agents
[+]

Biochanin A has suppressive effects on osteosarcoma through regulating cell proliferation, apoptosis, invasion, and migration.Dec 31, 2017

Pubmed Data : Pharmazie. 2018 06 1 ;73(6):335-341. PMID: 29880086
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Biochanin A impedes STAT3 activation by upregulating p38δ MAPK phosphorylation in IL-6-stimulated macrophages.Oct 31, 2020

Pubmed Data : Inflamm Res. 2020 Nov ;69(11):1143-1156. Epub 2020 Aug 27. PMID: 32852592
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, STAT3 Inhibitor
[+]

Biochanin A induces anticancer effects in SK-Mel-28 human malignant melanoma cells.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Nov ;14(5):5989-5993. Epub 2017 Sep 14. PMID: 29113236
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Malignant Melanoma
Pharmacological Actions : Anti-metastatic, Apoptotic
Additional Keywords : Dose Response
[+]

Biochanin A induces relaxation of the coronary artery.May 13, 2020

Pubmed Data : Planta Med. 2020 May 14. Epub 2020 May 14. PMID: 32408360
Article Published Date : May 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Hypertension
Pharmacological Actions : Vasodilator Agents
[+]

Biochanin A induces S phase arrest and apoptosis in lung cancer cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2018 ;2018:3545376. Epub 2018 Oct 3. PMID: 30402472
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Biochanin A is an attractive compound for preventing 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced wasting syndrome.Dec 31, 2018

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019 ;54(9):865-873. Epub 2019 Apr 20. PMID: 31007129
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Chronic Wasting Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Prostaglandin PGE2 downregulation
[+]

Biochanin A is effective in reducing pancreatic cancer cell survival by inhibiting their proliferation and inducing apoptosis.Feb 28, 2014

Pubmed Data : Anticancer Drugs. 2014 Mar ;25(3):296-302. PMID: 24201306
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Cancer Metastasis, Pancreatic Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Dose Response
[+]

Biochanin A may represent a breast cancer preventive agent, either administered alone or in combination with other flavonoids.Aug 31, 2008

Pubmed Data : Pharm Res. 2008 Sep ;25(9):2158-63. Epub 2008 May 3. PMID: 18454305
Article Published Date : Aug 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, EGCG (Epigallocatechin gallate), Quercetin
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Biochanin A might raise a possibility as a potential therapeutic agent for Alzheimer's disease and other related neurodegenerative diseases.Apr 24, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Apr 25 ;21(5). Epub 2016 Apr 25. PMID: 27120593
Article Published Date : Apr 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Biochanin A protects against fine particulate matter-induced acute pulmonary cell injury.Oct 13, 2019

Pubmed Data : Food Funct. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31608342
Article Published Date : Oct 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Biochanin A protects against oxidative damage in HepG2 cells.Jun 30, 2019

Pubmed Data : Biofactors. 2019 Jul ;45(4):563-574. Epub 2019 May 27. PMID: 31131946
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
[+]

Biochanin A reduces the abundance of proteolytic bacteria and production of ammonia.Feb 25, 2020

Pubmed Data : Animals (Basel). 2020 Feb 25 ;10(3). Epub 2020 Feb 25. PMID: 32106487
Article Published Date : Feb 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Red Clover
Diseases : Ammonia: Elevated
Pharmacological Actions : Antimicrobial
[+]

Biochanin A selectively inhibits the growth of Clostridium. Jan 01, 2010

Pubmed Data : Molecules. 2010;15(3):1270-9. Epub 2010 Mar 3. PMID: 20335979
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Clostridium Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Biochanin A significantly enhanced the anticancer efficacy of temozolomide in glioblastoma multiforme cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2019 Jan ;39(1):57-66. PMID: 30591440
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Biochanin-A could be potential enough for the betterment of Alzheimer's disease.Mar 31, 2014

Pubmed Data : Hum Exp Toxicol. 2014 Apr ;33(4):369-82. Epub 2013 Jul 30. PMID: 23900307
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Biochanin-A induces apoptosis and suppresses migration in FaDu human pharynx squamous carcinoma cells.Oct 31, 2017

Pubmed Data : Oncol Rep. 2017 Nov ;38(5):2985-2992. Epub 2017 Sep 13. PMID: 28901495
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Flavanoid rich honey may act as chemosensitizers in multidrug resistant cancers.Jan 17, 2011

Pubmed Data : Med Hypotheses. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21247706
Article Published Date : Jan 17, 2011
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Chrysin, Flavonoids, Genistein, Honey, Kaempferol, Naringenin , Quercetin
Diseases : Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer
[+]

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.Mar 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytother Res. 2021 Mar 30. Epub 2021 Mar 30. PMID: 33786876
Article Published Date : Mar 29, 2021
Study Type : Review
Additional Links
Substances : Biochanin A, Diosmin , EGCG (Epigallocatechin gallate), Epicatechin, Flavonoids, Genistein, Hesperidin, Luteolin, Naringenin , Quercetin, Rutin, Silymarin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Cytokine Storm
[+]

Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia.Apr 21, 2021

Pubmed Data : Arch Biochem Biophys. 2021 Apr 22 ;704:108889. Epub 2021 Apr 22. PMID: 33895119
Article Published Date : Apr 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Flavonoids, Formononetin, Genistein, Kaempferol
Diseases : Liver Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Gene Expression Regulation
[+]

Natural products may interfere With SARS-CoV-2 attachment to the host cell.May 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomol Struct Dyn. 2020 May 5:1-10. Epub 2020 May 5. PMID: 32340551
Article Published Date : May 04, 2020
Study Type : In Vitro Study
Additional Links
Substances : Alpha Linolenic Acid, Biochanin A, Caffeic Acid, Caffeic acid phenethyl ester, Chlorogenic Acid, Cinnamaldehyde, Formononetin, Genistein, Hydroxytyrosol, Thymoquinone
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Phytoestrogens-mediated induction of phase II detoxification enzymes may be responsible for their protective effect against estrogen-induced breast cancer. Jan 01, 2005

Pubmed Data : Biochem J. 2005 Jan 1;385(Pt 1):279-87. PMID: 15456407
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Genistein, Resveratrol
Diseases : Breast Cancer, DNA damage, Estrogen Dominance
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Estrogen Receptor Beta, Stilbenes
[+]

Potential lipid-lowering mechanisms of biochanin A.May 16, 2017

Pubmed Data : J Agric Food Chem. 2017 May 17 ;65(19):3842-3850. Epub 2017 May 4. PMID: 28447802
Article Published Date : May 16, 2017
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Hyperlipidemia
[+]

Prophylactic effect of biochanin A in lipopolysaccharide-stimulated BV2 microglial cells.May 31, 2020

Pubmed Data : Immunopharmacol Immunotoxicol. 2020 Jun 1:1-10. Epub 2020 Jun 1. PMID: 32482108
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Prophylactic Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Red clover demonstrates aromatase inhibition activity, which may reduce the risk of estrogen receptor positive breast cancer.Feb 01, 2008

Pubmed Data : Br J Nutr. 2008 Feb;99(2):303-10. Epub 2007 Aug 29. PMID: 17761019
Article Published Date : Feb 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Red Clover
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Seed germination of chickpeas (i.e. sprouting) increases the levels of four main isoflavones in chickpeas. Jan 01, 2009

Pubmed Data : J Liq Chromatogr Relat Technol. 2009 Jan 1;32(19):2879-2892. PMID: 20046900
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Chickpea, Isoflavones, Sprouts
[+]

The dietary isoflavone biochanin-A sensitizes prostate cancer cells to TRAIL-induced apoptosis.Mar 31, 2013

Pubmed Data : Urol Oncol. 2013 Apr ;31(3):331-42. Epub 2011 Jul 30. PMID: 21803611
Article Published Date : Mar 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Chemopreventive, Chemosensitizer
[+]

The isoflavones biochanin A and genistein inhibit the cell growth of stomach cancer lines by inducing programmed cell death. Dec 01, 1993

Pubmed Data : Cancer Res. 1993 Dec 1;53(23):5815-21. PMID: 8242641
Article Published Date : Dec 01, 1993
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Genistein, Isoflavones
Diseases : Stomach Cancer
Pharmacological Actions : Apoptotic
[+]

The isoflavones biochanin A, daidzein and especially genistein inhibit the growth of breast cancer cells, including those expressing the multi-drug resistance gene.Aug 30, 1991

Pubmed Data : Biochem Biophys Res Commun. 1991 Aug 30;179(1):661-7. PMID: 1883387
Article Published Date : Aug 30, 1991
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Daidzein, Genistein, Isoflavones
Diseases : Breast Cancer, Cancers: Multi-Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
[+]

The role of isoflavones in type 2 diabetes prevention and treatment-A narrative review.Dec 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Dec 28 ;22(1). Epub 2020 Dec 28. PMID: 33379327
Article Published Date : Dec 27, 2020
Study Type : Review
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents
[+]

There was synergy of biochanin A and ciprofloxacin against clinical isolates of Staphylococcus aureus.Aug 04, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2011 Aug 5 ;16(8):6656-66. Epub 2011 Aug 5. PMID: 25134769
Article Published Date : Aug 04, 2011
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Natural Substance/Drug Synergy
[+]

This is the first report of the presence of potent cyclooxygenase-2 inhibitors in Trifolium pratense L. extracts.Feb 28, 2019

Pubmed Data : J Sep Sci. 2019 Mar ;42(6):1133-1143. Epub 2019 Feb 25. PMID: 30620132
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Daidzein, Formononetin, Genistein, Isoflavones, Red Clover
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts

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