Butyrate

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11 Diseases Researched for Butyrate
NameACCKFocus
Dysbiosis12Locked
Hypertension12Locked
Sarcopenia12Locked
Sepsis12Locked
Cognitive Decline/Dysfunction11Locked
Colon Cancer11Locked
Colorectal Cancer11Locked
Kidney Cancer11Locked
Liver Cancer11Locked
Lymphoma11Locked
Neurodegenerative Diseases11Locked
13 Pharmacological Actions Researched for Butyrate
NameACCKFocus
Antioxidants24Locked
Apoptotic44Locked
Histone deacetylase inhibitor23Locked
Angiotensin-Converting Enzyme Inhibitors12Locked
Anti-Inflammatory Agents12Locked
Antihypertensive Agents12Locked
Antiproliferative 22Locked
Cell cycle arrest22Locked
Gastrointestinal Agents12Locked
Interleukin-6 Downregulation12Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor12Locked
MicroRNA modulator11Locked
Neuroprotective Agents11Locked

View the Evidence:
34 Abstracts with Butyrate Research

[+]

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Psychiatry. 2018 02 2 ;8(1):42. Epub 2018 Feb 2. PMID: 29391397
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Butyrate
Diseases : Autism, Mitochondrial Diseases, Oxidative Stress
[+]

Butyrate acts on the gut-brain neural circuit to improve energy metabolism via reducing energy intake and enhancing fat oxidation by activating BAT.Nov 02, 2017

Pubmed Data : Gut. 2017 Nov 3. Epub 2017 Nov 3. PMID: 29101261
Article Published Date : Nov 02, 2017
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents, Gut-brain Axis
[+]

Butyrate ameliorates antibiotic-driven type 1 diabetes in the female offspring of non-obese diabetic mice.Feb 11, 2020

Pubmed Data : J Agric Food Chem. 2020 Feb 12. Epub 2020 Feb 12. PMID: 32046486
Article Published Date : Feb 11, 2020
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Diabetes Mellitus: Type 1, Dysbiosis
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Risk Factors
[+]

Butyrate and dietary soluble fiber improves neuroinflammation associated with aging.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:1832. Epub 2018 Aug 14. PMID: 30154787
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Butyrate, Fiber
Diseases : Aging, Brain Inflammation , Dysbiosis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Epigenetic Modification
[+]

Butyrate could be a potential treatment to attenuate diabetic complications.Oct 31, 2019

Pubmed Data : J Mol Endocrinol. 2019 Nov 1. Epub 2019 Nov 1. PMID: 31770101
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Diabetic Complications, Dysbiosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Butyrate producing bacteria could be considered as a novel probiotic therapy for hypertension.Aug 31, 2016

Pubmed Data : J Hypertens. 2016 Sep ;34 Suppl 1 - ISH 2016 Abstract Book:e60-e61. PMID: 27753935
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Dysbiosis, Hypertension
Pharmacological Actions : Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Gastrointestinal Agents
Additional Keywords : Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Butyrate, Dysbiosis, Gastrointestinal Agents, hypertension
[+]

Butyrate protects against high-fat diet-induced atherosclerosis.Nov 24, 2019

Pubmed Data : Br J Pharmacol. 2019 Nov 25. Epub 2019 Nov 25. PMID: 31769014
Article Published Date : Nov 24, 2019
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Atherosclerosis, High Fat Diet
Pharmacological Actions : Anti-atherogenic, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic
[+]

Butyrate suppressed the abnormally increased proliferation in colonic epithelial cells under diabetic state by targeting HMGB1.Aug 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2018 Aug 31. Epub 2018 Aug 31. PMID: 30871870
Article Published Date : Aug 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Diabetic Complications
Pharmacological Actions : Antiproliferative , Gastroprotective
[+]

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.Apr 30, 2017

Pubmed Data : Nat Immunol. 2017 May ;18(5):552-562. Epub 2017 Mar 27. PMID: 28346408
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Autoimmune Diseases, Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions : Gastrointestinal Agents, Interleukin-21 downregulation
Additional Keywords : Microbiota
[+]

Increasing mitochondrial ATP synthesis with butyrate normalizes ADP and contractile function in metabolic heart disease.Feb 16, 2020

Pubmed Data : NMR Biomed. 2020 Feb 17:e4258. Epub 2020 Feb 17. PMID: 32066202
Article Published Date : Feb 16, 2020
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Heart Disease
Pharmacological Actions : Cardioprotective
[+]

Pre-treatment with butyrate attenuated septic heart depression via anti-inflammation and anti-oxidation.Nov 10, 2016

Pubmed Data : Am J Emerg Med. 2016 Nov 11. Epub 2016 Nov 11. PMID: 27884587
Article Published Date : Nov 10, 2016
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effects of butyrate on renal ischemia-reperfusion injury.Mar 06, 2019

Pubmed Data : Urol Int. 2019 Mar 7:1-8. Epub 2019 Mar 7. PMID: 30844816
Article Published Date : Mar 06, 2019
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Ischemia
Pharmacological Actions : Renoprotective
[+]

Sodium butyrate exerts protective effect against Parkinson's disease in mice.Oct 14, 2017

Pubmed Data : J Neurol Sci. 2017 Oct 15 ;381:176-181. Epub 2017 Aug 24. PMID: 28991675
Article Published Date : Oct 14, 2017
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sodium butyrate protects against noise-induced hearing loss in Guinea pigs.Oct 31, 2017

Pubmed Data : Neurosci Lett. 2017 Nov 1 ;660:140-146. Epub 2017 Sep 18. PMID: 28928030
Article Published Date : Oct 31, 2017
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Hearing Loss: Noise-Induced
[+]

These results provide insights into butyrate as a potential therapeutic for the treatment of inflammatory bowel disease.Mar 26, 2019

Pubmed Data : Inflamm Bowel Dis. 2019 Mar 27. Epub 2019 Mar 27. PMID: 30918945
Article Published Date : Mar 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-10 upregulation
[+]

This study is the first to show a beneficial effect of butyrate on muscle mass during aging.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Cell. 2015 Dec ;14(6):957-70. Epub 2015 Aug 20. PMID: 26290460
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Sarcopenia
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor
[+]

A high fiber diet in the gut might alter gene expression in the brain to prevent neurodegeneration and promote regeneration.Feb 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurosci Lett. 2016 Feb 8. Epub 2016 Feb 8. PMID: 26868600
Article Published Date : Feb 07, 2016
Study Type : Review
Additional Links
Substances : Butyrate, Fiber, Probiotics
Diseases : Cognitive Decline/Dysfunction, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Microbiome, Microbiota
[+]

A high-fiber diet and butyrate significantly inhibited the growth lymphoma tumors.Feb 16, 2016

Pubmed Data : Leuk Lymphoma. 2016 Feb 17:1-8. Epub 2016 Feb 17. PMID: 26885564
Article Published Date : Feb 16, 2016
Study Type : In Vitro Study
Additional Links
Substances : Butyrate, Fiber
Diseases : Lymphoma
Pharmacological Actions : Apoptotic
Additional Keywords : Microbiota
[+]

Butyrate alleviates inflammatory response and NF-κB activation in human degenerated intervertebral disc tissues.Nov 24, 2019

Pubmed Data : Int Immunopharmacol. 2019 Nov 25:106004. Epub 2019 Nov 25. PMID: 31780370
Article Published Date : Nov 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases.Jun 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Jun 5 ;9(43):27280-27292. Epub 2018 Jun 5. PMID: 29930765
Article Published Date : Jun 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.Mar 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2017 Mar 7 ;12:340-349. Epub 2017 Mar 7. PMID: 28288414
Article Published Date : Mar 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Antiproliferative, Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator
[+]

Butyrate inhibited hepatitis B replication and cell proliferation by inhibiting SIRT-1 expression in hepatoma cells.Mar 31, 2019

Pubmed Data : Mol Carcinog. 2019 Apr ;58(4):524-532. Epub 2018 Dec 19. PMID: 30501014
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Hepatitis B
Pharmacological Actions : Anticarcinogenic Agents, Antiviral Agents
[+]

Butyrate inhibits the proliferation and induces the apoptosis of colorectal cancer HCT116 cells.Feb 28, 2019

Pubmed Data : Mol Med Rep. 2019 Mar 1. Epub 2019 Mar 1. PMID: 30864709
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Butyrate or phenylbutyrate and could be novel types of prophylactic and therapeutic treatments for pterygium.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Ophthalmol. 2017 ;10(9):1337-1343. Epub 2017 Sep 18. PMID: 28944189
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Fibrosis, Pterygium
Pharmacological Actions : Anti-Fibrotic
[+]

Cathlecidin antimicrobial peptide synthesis is stimulated by retinoic acid and butyrate.Jul 01, 2005

Pubmed Data : Curr Issues Mol Biol. 2005 Jul ;7(2):179-96. PMID: 16053249
Article Published Date : Jul 01, 2005
Study Type : Review
Additional Links
Substances : Butyrate, Vitamin A
Pharmacological Actions : Antimicrobial, Immune Enhancing Properties, Immunomodulatory
[+]

Dially disulfide, a garlic constituent, works synergistically with butyrate to inhibit colorectal cancer cells. Oct 01, 2011

Pubmed Data : Nutr Cancer. 2011 Oct ;63(7):1104-13. Epub 2011 Sep 14. PMID: 21916706
Article Published Date : Oct 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Butyrate, Diallyl sulfide, Garlic
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
Additional Keywords : Natural Substance Synergy
[+]

Epigenetic regulation of the human ATP2A3 gene promoter in gastric and colon cancer cell lines.Jan 17, 2019

Pubmed Data : Mol Carcinog. 2019 Jan 18. Epub 2019 Jan 18. PMID: 30657210
Article Published Date : Jan 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colon Cancer, Gastric Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Epigenetic Modification In Cancer
[+]

Fermented wheat aleurone inhibits growth and induces programmed cell death in human colon cancer cells.Feb 01, 2010

Pubmed Data : Br J Nutr. 2010 Feb;103(3):360-9. Epub 2009 Sep 7. PMID: 19732471
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Aleurone, Butyrate, Fiber, Wheat: Fermented
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Gum arabic intake may result in the increased production of butyrate, which may have beneficial effects on renal pro-fibrotic cytokine generation.Jan 01, 2006

Pubmed Data : Kidney Int. 2006 Jan;69(2):257-65. PMID: 16408114
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Butyrate, Gum arabic
Diseases : Kidney Cancer
[+]

Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber.Dec 31, 2017

Pubmed Data : Clin Colorectal Cancer. 2018 09 ;17(3):e541-e544. Epub 2018 May 17. PMID: 29866614
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colon Cancer, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive
[+]

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases.Mar 27, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2011 Mar 28 ;17(12):1519-28. PMID: 21472114
Article Published Date : Mar 27, 2011
Study Type : Review
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer, Hypercholesterolemia, Insulin Resistance, Metabolic Diseases, Stroke: Ischemic
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive
[+]

Sodium butyrate promotes apoptosis in breast cancer cells.Nov 01, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2017 Nov 2 ;16(1):208. Epub 2017 Nov 2. PMID: 29096636
Article Published Date : Nov 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?Jan 09, 2016

Pubmed Data : Neurochem Int. 2016 10 ;99:110-132. Epub 2016 Jun 23. PMID: 27346602
Article Published Date : Jan 09, 2016
Study Type : Review
Additional Links
Substances : Butyrate
Diseases : Neurological Conditions
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gut-brain Axis
[+]

This reviews the effects of butyrate on modulating miRNA expression in colorectal cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Epigenet. 2017 ;9:1179237X17729900. Epub 2017 Sep 25. PMID: 28979170
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer
Pharmacological Actions : Chemoprotective Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer

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