Cannabinoids

Name	AC	CK
Multiple Sclerosis	43	201
Epilepsy	44	199
Anxiety	22	90
Inflammation	48	84
Neuropathic Pain	16	81
Dravet syndrome	8	64
Parkinson's Disease	20	62
Cancers: All	41	60
Autism Spectrum Disorders	8	53
Epilepsy: Childhood	6	53
Inflammatory Bowel Diseases	13	46
Seizures	9	45
Stroke	4	43
Stroke: Attenuation/Recovery	6	39
Pain	6	35
Alzheimer's Disease	25	33
Neurodegenerative Diseases	22	33
Chronic Pain	11	30
Glioma	18	30
Anxiety Disorders	8	29
Depression	16	29
Breast Cancer	19	28
Schizophrenia	14	28
Huntington Disease	10	27
Brain Inflammation	19	26
Morphine Tolerance/Dependence	4	26
Tourette Syndrome	4	26
Diabetes Mellitus: Type 2	4	25
Lennox-Gastaut Syndrome	6	25
Amyotrophic lateral sclerosis (ALS)	4	24
Psychoses	6	24
Muscle Spasticity	3	22
Glioblastoma Multiforme	9	21
Marijuana Addiction/Withdrawal	3	21
Post-Traumatic Stress Disorders (PTSD)	9	21
Acne	2	20
Hypoglycemia	1	20
Opioid Tolerance/Dependence	1	20
Oxidative Stress	12	19
Stroke: Ischemic	4	19
Lipopolysaccharide-Induced Toxicity	12	18
Memory Disorders	5	18
Nonalcoholic fatty liver disease (NAFLD)	4	18
Hyperalgesia	7	17
Sleep Disorders	4	17
Lung Cancer	11	16
Brain Ischemia	7	15
Cancer: Pain	5	15
Colitis	7	15
Dry Skin	1	15
Glioblastoma	9	15
Spinal Cord Injuries	4	15
Ulcerative Colitis	2	15
Brain Cancer	3	14
HIV Infections	4	14
Brain Damage: Hypoxic Ischemic Insult	6	13
Brain: Microglial Activation	6	13
Encephalopathy	2	13
Insomnia	2	13
Obsessive-Compulsive Disorder	3	13
Bladder Dysfunction	2	12
Cancer Metastasis	9	12
Colon Cancer	8	12
Epileptic Seizures	2	12
Hypertension	2	12
Amyotrophic Lateral Sclerosis	7	11
Cerebral Ischemia	5	11
Endocannabinoid Disorders	2	11
Ovarian Cancer	2	11
Astrocytoma	4	10
Attention Deficit Hyperactivity Disorder	1	10
Brachial Plexus Neuropathies	1	10
Child Behavior Disorders	1	10
Cocaine Addiction	1	10
Delirium: Drug-Induced	1	10
Fibromyalgia	1	10
Impairment: Driving Related	1	10
Learning disorders	1	10
Organ Transplantation: Kidney	1	10
Overactive Bladder	1	10
Pancreatitis: Chronic	1	10
Peripheral Nerve Diseases	1	10
Prostate Cancer	8	10
Quality of Life: Poor	1	10
Social Anxiety Disorder (SAD)	1	10
Sturge-Weber Syndrome	1	10
Temporal Lobe Epilepsy (TLE)	1	10
Tuberous Sclerosis	1	10
Vaccine-induced Toxicity	1	10
Allodynia	5	9
Chemotherapy-Induced Toxicity: Cisplatin	4	9
Lymphoma	4	9
Breast Cancer: Triple Negative	6	8
Cardiovascular Diseases	3	8
Colorectal Cancer	6	8
Dementia	5	8
Diabetic Complications	5	8
Melanoma	5	8
Obesity	4	8
Psychiatric Disorders	7	8
Skin Cancer	5	8
Traumatic Memory Formation	4	8
Endocannabinoid System	7	7
Glaucoma	4	7
Middle Cerebral Artery Occlusion (MCAO)	4	7
Coronavirus Infection	6	6
Diabetes Mellitus: Type 1	3	6
Myocardial Infarction	3	6
Osteoarthritis	5	6
Pancreatic Cancer	6	6
Alcoholic Liver Disease	1	5
Asthma	3	5
Brain: Oxidative Stress	3	5
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Diabetes Mellitus: Type 1: Prevention	3	5
Drug Abuse	3	5
Gastrointestinal Inflammation	2	5
Psychiatric Disorder: Conditioned Fear	3	5
Acute Myeloid Leukemia	2	4
Alcohol Toxicity	3	4
Arthritis	3	4
Autoimmune Diseases	3	4
Bladder Cancer	3	4
Brain Damage	3	4
Brain Injury: Traumatic	2	4
Cachexia	3	4
Cocaine Toxicity	2	4
Colon Cancer: Prevention	2	4
Diabetes: Cataract	2	4
Diabetic Neuropathies	1	4
Emesis	1	4
Endotoxemia	2	4
Eye Damage	1	4
Febrile Seizures	2	4
Iron Overload	2	4
Ischemia	2	4
Liver Cancer	3	4
Metabolic Syndrome X	1	4
Myocardial Ischemia	2	4
Psychotic Disorders	3	4
Vomiting	1	4
Aging	2	3
Astrocytoma: Grade IV	1	3
Autism	2	3
Cachexia: Cancer	3	3
Chemotherapy and Radiation Toxicity	2	3
Chemotherapy-Induced Nausea	3	3
Chemotherapy-Induced Toxicity: Paclitaxel	2	3
Drug Addiction	2	3
Encephalomyelitis	2	3
Epidermolysis Bullosa	1	3
Epilepsy: Infant	1	3
Epilepsy: Malignant Migrating Partial Seizures	1	3
Fibrosis	2	3
Gastric Cancer	3	3
Gastrointestinal Diseases	2	3
Gliomas	2	3
Liver Fibrosis	2	3
Neuroblastoma	2	3
Oral Mucositis	2	3
Psoriasis	3	3
Thyroid Cancer	2	3
Aging: Brain	1	2
Alcohol Addiction	2	2
Alcohol Withdrawal	1	2
Amphetamine Addiction/Withdrawal	1	2
Angelman Syndrome	1	2
Appetite Disorders: Loss/Lack of	1	2
Arteriosclerosis	1	2
Atopic Dermatitis	1	2
Bipolar Disorder	1	2
Bone Fractures	1	2
Brain Edema	1	2
Breast Cancer: Lung Metastasis	1	2
Breast Cancer: Metastatic	1	2
Breast Cancer: Prevention	1	2
Cachexia: Chemotherapy Induced	1	2
Cancers: Drug Resistant	2	2
Cardiac Arrhythmias	1	2
Cardiomyopathy	1	2
Cerebral Hypoperfusion	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Chemotherapy-Induced Toxicity: Vincristine	1	2
Cocaine Withdrawal	1	2
Cognitive Decline/Dysfunction	1	2
Degenerative Disk Disease	1	2
Depression	1	2
Depressive Disorder	1	2
Dermatitis	1	2
Dermatitis: Contact	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Memory Problems	1	2
Diabetic Neuropathy	1	2
Diabetic Retinopathy	1	2
Endometrial Cancer	1	2
Endothelial Dysfunction	1	2
Epilepsy: Drug-Induced	1	2
Fatty Liver	1	2
Friedreich Ataxia	1	2
Fulminant Hepatic Failure	1	2
Gastroschisis	1	2
Head and Neck Cancer	1	2
Headache	2	2
Heart Attack	1	2
Hepatic Encephalopathy	1	2
Hepatitis C	2	2
High Fat Diet	1	2
Hydrogen Peroxide Induced Toxicity	2	2
Hypersensitivity	1	2
Hypersensitivity: Type IV	1	2
Hypertension: Pulmonary	1	2
Infant Neurological Development	1	2
Inflammation: Neutrophil-Mediated	1	2
Insulin Resistance	1	2
Interstitial Lung Diseases	1	2
Leukemia	2	2
Liver Damage	1	2
Liver Failure: Acute	1	2
Liver Injury: Ischemia/reperfusion	1	2
Malaria	1	2
Memory Disorders: Drug-Induced	1	2
Metabolic Diseases	1	2
Mitochondrial Dysfunction	1	2
Multiple Myeloma	2	2
Muscle Soreness	1	2
Myocarditis: Autoimmune	1	2
Neonatal Stroke	1	2
Neuralgia	1	2
Neurologic Disorders	2	2
Periodontitis	1	2
Prion Diseases	1	2
Rhabdomyosarcoma	1	2
Sciatic Nerve Crush Injury	1	2
Sepsis	1	2
Skin Diseases: Inflammatory	1	2
Spinal Cord Inflammation	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Tardive Dyskinesia	1	2
Traumatic Brain Injury	1	2
Tremor	1	2
Ultraviolet Radiation Induced Damage	2	2
Urinary Bladder Diseases	1	2
Uveitis	1	2
AIDS	1	1
Acetaminophen (Tylenol) Toxicity	1	1
Acquired Immunodeficiency Syndrome	1	1
Acute T cell Leukemias	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Allergies	1	1
Anorexia	1	1
Appetite Disorders	1	1
Arrhythmias: Cardiac	1	1
Atherosclerosis	1	1
Bone Diseases	1	1
Burkitt Lymphoma	1	1
Cadmium Poisoning	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Albicans	1	1
Candida Infection	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Central Nervous System Diseases	1	1
Cervical Cancer	1	1
Cirrhosis	1	1
Clostridium Infections	1	1
Cough	1	1
Diabetes: Cognitive Dysfunction	1	1
Dry Eye Syndromes	1	1
Ebola Virus Infections	1	1
Eczema	1	1
Escherichia coli Infections	1	1
Eye Diseases	1	1
Gram-Positive Bacterial Infections	1	1
Herpes Simplex Virus Type 2	1	1
Herpes: Kaposi-Associated	1	1
Immune Disorders	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Influenza	1	1
Irritable Bowel Syndrome	1	1
Kaposi Disease	1	1
Kidney Cancer	1	1
Kidney Damage	1	1
Leishmaniasis	1	1
Leukemia: T-cell acute Lymphoblastic	1	1
Lung Injury: Acute	1	1
Methicillin-resistant Staphylococcus aureus	1	1
Mood Disorders	1	1
Nausea: Chemotherapy-Induced	1	1
Neurological Conditions	1	1
Oral Cancer	1	1
Osteoporosis	1	1
Peripheral Neuropathies	1	1
Prostate: PSA Doubling	1	1
Pruritus	1	1
Pseudomonas aeruginosa	1	1
Rheumatoid Arthritis	1	1
Skin Diseases	1	1
Staphylococcus aureus infection	1	1
Testicular Cancer	1	1
Tobacco Addiction/Withdrawal	1	1
Wound Healing	1	1

Name	AC	CK
Neuroprotective Agents	136	322
Anticonvulsants	52	280
Anti-Inflammatory Agents	121	273
Analgesics	42	162
Anti-Anxiety Agents	29	113
Antiproliferative	68	112
Apoptotic	73	108
Antioxidants	35	50
Tumor Necrosis Factor (TNF) Alpha Inhibitor	23	44
Immunomodulatory	21	40
Antidepressive Agents	18	35
Anti-metastatic	23	32
Antineoplastic Agents	22	31
Vasodilator Agents	5	31
Angiogenesis Inhibitors	15	30
Chemotherapeutic	21	29
Antinoceceptive	8	25
Hypoglycemic Agents	2	22
Chemopreventive	7	20
Cyclooxygenase 2 Inhibitors	6	19
Hepatoprotective	9	18
Immunosuppressive Agents	6	17
Anti-Apoptotic	10	16
Interleukin-6 Downregulation	9	16
NF-kappaB Inhibitor	10	16
Antihypertensive Agents	4	15
Autophagy Up-regulation	9	15
Cardioprotective	8	14
Chemoprotective Agents	6	13
Antipsychotic Agents	8	12
Antispasmodic	2	12
Cell cycle arrest	9	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	12
Vascular Endothelial Growth Factor Inhibitors	3	12
Anxiolytic	2	11
Chemosensitizer	8	11
Interleukin-1 beta downregulation	7	11
Anti-Tumor	5	10
Anticarcinogenic Agents	7	10
GABA Modulators	1	10
Interferon Gamma Reducer	5	9
Neurogenesis	7	9
Brain-derived neurotrophic factor modulator	4	8
Hypolipidemic	2	7
Anti-Bacterial Agents	6	6
Nitric Oxide Inhibitor	3	6
P38 Mitogen-Activated Protein Kinase Modulator	2	6
Superoxide Dismutase Up-regulation	2	6
Vascular Cell Adhesion Molecule-1 Inhibitor	2	6
Anti-Angiogenic	5	5
Appetite Stimulants	3	5
Cannabinoid Receptor Antagonist/Inverse Agonist	3	5
Neuritogenic	3	5
Anti-Fibrotic	3	4
Antiviral Agents	4	4
Caspase-3 Activation	3	4
Enzyme Inhibitors	2	4
Gastrointestinal Agents	4	4
Interleukin-10 downregulation	2	4
Interleukin-17 downregulation	3	4
Interleukin-4 downregulation	2	4
Interleukin-8 downregulation	3	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	4
Osteoprotective	3	4
Prostaglandin PGE2 downregulation	2	4
Vascular Endothelial Growth Factor A Inhibitor	2	4
Vascular Endothelial Growth Factor Regulator	2	4
Cytotoxic	2	3
Immunomodulatory: Th17 downregulation	2	3
Prophylactic Agents	2	3
Radiosensitizer	2	3
Renoprotective	2	3
Aldose reductase inhibitor	1	2
Anti-Androgen	1	2
Anti-atherogenic	1	2
Anticholesteremic Agents	1	2
Calcium Channel Blockers	1	2
Cyclooxygenase Inhibitors	1	2
Enzyme Activators	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Gastroprotective	2	2
Glycine Agents	1	2
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Immunomodulatory: T-Cell down-regulation	1	2
Immunostimulatory	1	2
Interleukin-10 upregulation	1	2
Interleukin-12 downregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-5 downregulation	1	2
Intracellular adhesion molecule-1 (ICAM-1)	1	2
Malondialdehyde Down-regulation	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	2
MicroRNA modulator	2	2
Neuroplasticity enhancement	1	2
Pancreato Protective Agents	1	2
Photoprotective	2	2
Redox Modulator	1	2
Sedative effects	1	2
Topoisomerase II Inhibitor	2	2
Vanilloid Receptor-1 Modulator	1	2
interleukin-13 down-regulation	1	2
Anti-Allergic Agents	1	1
Anti-Cachexic Agents	1	1
Anti-Infective Agents	1	1
Anti-Proliferative	1	1
Anti-Psychotic	1	1
Antifungal Agents	1	1
Caspase-8 activation	1	1
Caspase-9 Activation	1	1
Cyclooxygenase 1 Inhibitor	1	1
Interleukin-2 upregulation	1	1
NADPH Oxidase Inhibitors	1	1
Neuroimmunomodulation	1	1
Nrf2 activation	1	1
Paraptosis	1	1
Regenerative	1	1
Transient receptor potential vanilloid type-2 activation	1	1
Wnt/β-catenin signaling pathway modulation	1	1
apoptosis	1	1

[+]

A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.Nov 02, 2018

Click here to read the entire abstract

Pubmed Data : Drugs. 2018 Nov 3. Epub 2018 Nov 3. PMID: 30390221

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2017 ;8:81. Epub 2017 Feb 24. PMID: 28286481

Article Published Date : Dec 31, 2016

Study Type : Meta Analysis, Review

Additional Links

Substances : Cannabidiol

Diseases : Stroke

Pharmacological Actions : Vasodilator Agents

[+]

A case report of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.Jul 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mov Disord. 2021 Mar 22. Epub 2021 Mar 22. PMID: 33754375

Article Published Date : Mar 21, 2021

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Parkinson's Disease

[+]

[+]

Cannabidiol in the treatment of post-traumatic stress disorder.Dec 12, 2018

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Pubmed Data : J Altern Complement Med. 2018 Dec 13. Epub 2018 Dec 13. PMID: 30543451

Article Published Date : Dec 12, 2018

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Post-Traumatic Stress Disorders (PTSD)

Additional Keywords : Significant Treatment Outcome

[+]

Click here to read the entire abstract

Pubmed Data : Clin Infect Dis. 2018 Feb 17. Epub 2018 Feb 17. PMID: 29471387

Article Published Date : Feb 16, 2018

Study Type : Human Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : HIV Infections

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

[+]

Cannabis extracts can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs.May 08, 2016

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Anti Therapeutic Actions : Vaccination: HPV (Gardasil)

[+]

CBD has anxiolytic properties in human volunteers submitted to a stressful situation.Dec 31, 1992

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Pubmed Data : J Psychopharmacol. 1993 Jan ;7(1 Suppl):82-8. PMID: 22290374

Article Published Date : Dec 31, 1992

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Anxiety

Pharmacological Actions : Anti-Anxiety Agents

[+]

Click here to read the entire abstract

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Pubmed Data : Psychopharmacology (Berl). 2021 Apr 4. Epub 2021 Apr 4. PMID: 33813611

Article Published Date : Apr 03, 2021

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Anxiety

Pharmacological Actions : Anti-Anxiety Agents

[+]

Fibromyalgia patients saw many benefits from using CBD across multiple symptoms domains.Jan 01, 2021

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Pubmed Data : J Pain. 2021 Jan 2. Epub 2021 Jan 2. PMID: 33400996

Article Published Date : Jan 01, 2021

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Fibromyalgia

[+]

In this trial cannabis induced a clinical remission in 50% of patients with long standing Crohn's disease with 80% nonresponse or intolerance to anti–TNF-α treatment.Sep 30, 2013

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Pubmed Data : Clin Gastroenterol Hepatol. 2013 Oct ;11(10):1276-1280.e1. Epub 2013 May 4. PMID: 23648372

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Substances : Cannabinoids , Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs, Significant Treatment Outcome

[+]

Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.Feb 10, 2019

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The results reported here are very promising and indicate that CBD-enriched cannabis extract may ameliorate multiple autism spectrum disorders symptoms.Dec 31, 2018

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Pubmed Data : Front Neurol. 2019 ;10:1145. Epub 2019 Oct 31. PMID: 31736860

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Autism Spectrum Disorders

Pharmacological Actions : Neuroprotective Agents

[+]

Additional Keywords : Anti-Inflammatory Agents, Cannabinoids, Immunosuppressive Agents, Inflammation, Pancreatitis: Chronic

[+]

These results suggest that CBD has anxiolytic properties.Jan 31, 2004

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Pubmed Data : Epilepsy Res. 2021 Mar 8 ;172:106603. Epub 2021 Mar 8. PMID: 33725662

Article Published Date : Mar 07, 2021

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy

[+]

Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.Jul 06, 1998

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Pubmed Data : Proc Natl Acad Sci U S A. 1998 Jul 7 ;95(14):8375-80. PMID: 9653194

Article Published Date : Jul 06, 1998

Study Type : Human In Vitro

Additional Links

Substances : Anandamide, Cannabinoids

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cannabinoid Receptors, Dose Response

[+]

Cannabidiol causes vasorelaxation of the human mesenteric artery.Aug 31, 2015

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Pubmed Data : Cardiovasc Res. 2015 Sep 1 ;107(4):568-78. Epub 2015 Jun 19. PMID: 26092099

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2004 Mar ;56(3):291-7. PMID: 15025853

Article Published Date : Feb 29, 2004

Study Type : Human In Vitro

Additional Links

Substances : Cannabidiol, Cannabinoids

[+]

Phytocannabinoids could be efficient and safe novel treatments in the management of cutaneous inflammations.Apr 19, 2016

Click here to read the entire abstract

Pubmed Data : Exp Dermatol. 2016 Apr 20. Epub 2016 Apr 20. PMID: 27094344

Article Published Date : Apr 19, 2016

Study Type : Human In Vitro

Additional Links

Substances : Cannabidiol, Cannabidivarin, Cannabigerol , Cannabigerovarin , Cannabinoids

Diseases : Acne, Dry Skin

Pharmacological Actions : Anti-Inflammatory Agents

[+]

The present data suggest that targeting CB(1)/CB(2) may have therapeutic potential for the treatment of mantle cell lymphoma.Oct 31, 2006

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Pubmed Data : Mol Pharmacol. 2006 Nov ;70(5):1612-20. Epub 2006 Aug 25. PMID: 16936228

Article Published Date : Oct 31, 2006

Study Type : Human In Vitro

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Lymphoma

Pharmacological Actions : Apoptotic, P38 Mitogen-Activated Protein Kinase Modulator

Additional Keywords : Selective Cytotoxicity

[+]

The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.Mar 31, 2006

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Pubmed Data : Phytomedicine. 2020 Nov 30 ;81:153426. Epub 2020 Nov 30. PMID: 33341026

Article Published Date : Nov 29, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Inflammation, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective

[+]

[+]

Activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine.Dec 31, 2014

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[+]

Cannabidiol and abnormal cannabidiol reduced the infarct volume. Apr 30, 2005

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Pubmed Data : Stroke. 2005 May ;36(5):1077-82. Epub 2005 Apr 21. PMID: 15845890

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Pubmed Data : J Clin Invest. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31503547

Article Published Date : Sep 09, 2019

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Angelman Syndrome, Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

[+]

Cannabidiol controls the exaggerated inflammatory response observed in an animal model of asthma.Dec 31, 2014

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Pubmed Data : Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID: 20053780

Article Published Date : Dec 31, 2009

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Cancer Metastasis, Glioblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Cannabinoid Receptors, Natural Substance Synergy

[+]

Cannabidiol enhanced the hippocampal immune response and autophagy of APP/PS1 Alzheimer's mice.Dec 31, 2020

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Pubmed Data : Life Sci. 2021 Jan 1 ;264:118624. Epub 2020 Oct 21. PMID: 33096116

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Alzheimer's Disease

Pharmacological Actions : Immunostimulatory, Neuroprotective Agents

[+]

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.Jan 25, 2020

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Pubmed Data : Sci Rep. 2020 11 26 ;10(1):20622. Epub 2020 Nov 26. PMID: 33244087

Article Published Date : Jan 25, 2020

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Head and Neck Cancer

Pharmacological Actions : Apoptotic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin

[+]

Cannabidiol exhibits an anticonvulsive effect in the rats with chronic epilepsy.Dec 31, 2014

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Pubmed Data : Int J Clin Exp Med. 2015 ;8(6):8820-7. Epub 2015 Jun 15. PMID: 26309534

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy, Epilepsy: Drug-Induced

Pharmacological Actions : Anticonvulsants, Neuroprotective Agents

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Cannabidiol exhibits an antipsychotic-like profile without inducing extrapyramidal-like effects.Apr 10, 2005

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Pubmed Data : Eur J Pharmacol. 2005 Apr 11 ;512(2-3):199-205. PMID: 15840405

Article Published Date : Apr 10, 2005

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Pharmacological Actions : Antipsychotic Agents

Additional Keywords : Antipsychotic Agents, Cannabidiol, Natural Substances Versus Drugs

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Br J Pharmacol. 2008 Jul ;154(5):1001-8. Epub 2008 May 12. PMID: 18469842

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Enzyme Inhibitors

Problem Substances : Croton oil

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Cannabidiol may represent a promising new protective strategy against cisplatin-induced nephrotoxicity.Feb 28, 2009

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Pubmed Data : J Mol Med (Berl). 2012 Aug ;90(8):925-34. Epub 2012 Jan 10. PMID: 22231745

Pubmed Data : Addict Biol. 2017 Feb 13. Epub 2017 Feb 13. PMID: 28194850

Article Published Date : Feb 12, 2017

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Alcohol Withdrawal

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Cannabidiol reduces lung injury induced by hypoxic-ischemic brain damage.Apr 06, 2017

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Pubmed Data : Pediatr Res. 2017 Apr 7. Epub 2017 Apr 7. PMID: 28388598

Article Published Date : Apr 06, 2017

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Brain Damage: Hypoxic Ischemic Insult

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

Additional Keywords : Anti-Inflammatory Agents, Brain Damage: Hypoxic Ischemic Insult, Cannabidiol, Neuroprotective Agents

[+]

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy modelsDec 25, 2018

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Pubmed Data : Autoimmunity. 2006 Mar ;39(2):143-51. PMID: 16698671

Article Published Date : Feb 28, 2006

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Diabetes Mellitus: Type 1: Prevention

Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Risk Reduction, Significant Treatment Outcome

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cannabidiol was able to produce a significant antitumor activity both in vitro and in vivo.Feb 29, 2004

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Pubmed Data : Neuropharmacology. 2008 Dec ;55(8):1280-6. Epub 2008 Jun 27. PMID: 18634812

Article Published Date : Nov 30, 2008

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Hypertension, Middle Cerebral Artery Occlusion (MCAO)

Pharmacological Actions : Neuroprotective Agents

[+]

Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.Jan 17, 2019

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Pubmed Data : Cancer Lett. 2019 Jan 18 ;447:12-23. Epub 2019 Jan 18. PMID: 30660647

Article Published Date : Jan 17, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic

[+]

Cannabidiol-transdermal delivery has an anti-inflammatory effect in a murine model.Dec 11, 2003

Pubmed Data : Nat Chem Biol. 2011 May;7(5):296-303. Epub 2011 Apr 3. PMID: 21460829

Article Published Date : May 01, 2011

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Pain

Pharmacological Actions : Analgesics, Glycine Agents

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Cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis.Jun 30, 2009

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Pubmed Data : Mol Cancer Ther. 2009 Jul ;8(7):1838-45. Epub 2009 Jun 9. PMID: 19509271

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Pubmed Data : FASEB J. 2003 Mar ;17(3):529-31. Epub 2003 Jan 2. PMID: 12514108

Article Published Date : Feb 28, 2003

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Cancers: All, Gliomas

Pharmacological Actions : Angiogenesis Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Regulator

Additional Keywords : Disease Regression

[+]

Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

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Pubmed Data : FASEB J. 2006 Dec ;20(14):2633-5. Epub 2006 Oct 25. PMID: 17065222

Article Published Date : Nov 30, 2006

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Melanoma

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Cannabinoid Receptors, Selective Cytotoxicity

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Cannabis extracts have therapeutic potential to slow multiple sclerosis progression and repair the central nervous system.Jun 30, 2015

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Pubmed Data : Br J Pharmacol. 2015 Jul ;172(14):3579-95. Epub 2015 May 20. PMID: 25857324

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Cannabis may provide support as a novel disease-modifying therapy in ALS.Aug 31, 2014

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Pubmed Data : CNS Neurosci Ther. 2014 Sep ;20(9):809-15. Epub 2014 Apr 7. PMID: 24703394

Article Published Date : Aug 31, 2014

Study Type : Transgenic Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Amyotrophic lateral sclerosis (ALS)

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Cannabis sativa extract has an antihyperalgesic effect in a rat model of neuropathic pain.Jul 31, 2008

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Pubmed Data : Phytother Res. 2008 Aug ;22(8):1017-24. PMID: 18618522

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CBD induces antidepressant-like effects comparable to those of imipramine. Dec 31, 2009

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Pubmed Data : Br J Pharmacol. 2010 Jan ;159(1):122-8. Epub 2009 Dec 4. PMID: 20002102

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View the Evidence: 697 Abstracts with Cannabinoids Research

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A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.Nov 02, 2018

A systematic review and meta-analysis off the effects of cannabinoids in Amyotrophic lateral sclerosis murine models.Dec 05, 2018

Adjunctive CBD resulted in a greater reduction in convulsive seizure frequency.Feb 09, 2020

Cannabinoids may have possible therapeutic properties for the management of the multiple sclerosis.Nov 19, 2010

Cannabinoids significantly reduced infarct volume and improve functional outcome in experimental stroke models.Feb 28, 2015

Selective cannabinoids provide a small analgesic benefit in patients with chronic neuropathic pain.May 18, 2017

The median effective dose of morphine administered in combination with THC is 3.6 times lower than of morphine alone.Mar 21, 2017

This meta-analysis and systematic review has highlighted the haemodynamic effects of CBD.Dec 31, 2016

A case report of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.Jul 31, 2019

A single dose of cannabidiol reduces blood pressure in healthy volunteers.Jun 14, 2017

A tetrahydrocannabinol:cannabidiol (THC:CBD) extract is efficacious for relief of pain in patients with advanced cancer pain not fully relieved by strong opioids.Jul 01, 2009

Acute cannabidiol administration at a dose of 300 mg decreased anxiety in patients with Parkinson's disease.Jan 06, 2020

Add-on cannabidiol may be an efficacious long-term treatment option for treatment-resistant epilepsies.Jul 11, 2018

Cannabidiol acts at 5-HT 1A receptors in the human brain: Relevance for treating temporal lobe epilepsy. Dec 31, 2019

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.Aug 21, 2019

Cannabidiol could be useful in Dravet syndrome treatments. Mar 31, 2016

Cannabidiol could reduce severe behavioural problems in children and adolescents with intellectual disability. May 31, 2020

Cannabidiol for rapid eye movement sleep behavior disorder. Mar 21, 2021

Cannabidiol for the treatment of crack-cocaine craving.Oct 29, 2020

Cannabidiol for treating drug-resistant epilepsy in children.Aug 12, 2018

Cannabidiol for treating Lennox-Gastaut Syndrome and Dravet Syndrome in Korea Dec 27, 2020

Cannabidiol has antipsychotic properties which balance out the psychotomimetic effects of THC in cannabis.Apr 01, 2008

Cannabidiol improves frequency and severity of seizures and reduces adverse events.Aug 08, 2018

Cannabidiol in the treatment of post-traumatic stress disorder.Dec 12, 2018

Cannabidiol levels in different strains of cannabis may determine the degree to which THC interferes with memory in users.Oct 01, 2010

Cannabidiol may be an effective and well-tolerated treatment option for patients with refractory seizures in Tuberous sclerosis complex.Sep 30, 2016

Cannabidiol may hold benefit for anxiety-related disorders. Dec 31, 2018

Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.Dec 22, 2015

Cannabidiol reduces anxiety in social anxiety disorder through modulating the limbic and paralimbic brain areas. Sep 09, 2010

Cannabidiol resulted in a greater reduction in convulsive-seizure frequency among patients with Dravet syndrome.Jan 24, 2017

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.Jan 05, 2016

Cannabinoid treatment for autism: a proof-of-concept randomized trial.Feb 02, 2021

Cannabinoids may have therapeutic value in the treatment of tics in Tourette syndrome. Oct 01, 2003

Cannabis and cannabinoids in cancer pain management.May 31, 2020

Cannabis could be potentially beneficial reduction in systemic inflammation and immune activation in the context of antiretroviral-treated HIV infection.Feb 16, 2018

Cannabis extracts can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs.May 08, 2016

Cannabis extracts can be considered an alternative in patients with spasticity associated with chronic spinal cord injury.Sep 30, 2017

Cannabis in ASD patients appears to be well tolerated, safe and effective option to relieve symptoms associated with ASD.Jan 16, 2019

Cannabis is well-tolerated and efficacious in the treatment of neuropathic pain from brachial plexus avulsion.Dec 01, 2004

Cannabis may have therapeutic value in the treatment of Tourette syndrome.Dec 01, 1998

Cannabis-based medicine is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain and is mostly well tolerated.Sep 27, 2005

Cannabis-based medicine may represent a useful new agent for treatment of the symptomatic relief of spasticity in MS.Feb 28, 2007

CBD could be beneficial for the treatment of brain tumor-related epilepsy.Oct 23, 2017

CBD enriched hemp oil could be beneficial in girls with adverse drug effects following human papillomavirus (HPV) vaccine.Jan 31, 2017

CBD has anxiolytic properties in human volunteers submitted to a stressful situation.Dec 31, 1992

CBD may be effective, safe and well tolerated for the treatment of the psychosis in Parkinson's disease.Oct 31, 2009

CBD restores excitability and morphological impairment in epileptic models to pre-epilepsy control levels.Mar 24, 2018

CBD was found to have potential benefits as add-on therapy for refractory childhood epilepsies.Mar 07, 2018

CBD-rich botanical extract may be beneficial for symptomatic treatment of ulcerative colitis.Mar 09, 2018

Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay.Feb 28, 2018

Cognitive and behavioral effects of cannabidiol in patients with treatment-resistant epilepsy.Nov 23, 2020

Delta-tetrahydrocannabinol (THC) and cannabidiol have therapeutic value in the management of spasticity associated wtih multiple sclerosis. Aug 01, 1996

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Drivers under the influence of synthetic cannabinoids were more frequently impaired with confusion, disorientation, and incoherent, slurred speech than drivers under the influence of marijuana in this population evaluated by drug recognition experts.Dec 31, 2015

Dronabinol is a safe long-term treatment option for neuropathic pain patients.Oct 25, 2017

Effectiveness of cannabidiol in a prospective cohort of children with drug-resistant epileptic encephalopathy.Jun 05, 2020

Effects of cannabidiol on brain excitation and inhibition systems.Feb 05, 2019

Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

Evaluating cannabidiol expectancy effects on acute stress and anxiety in healthy adults.Apr 03, 2021

Fibromyalgia patients saw many benefits from using CBD across multiple symptoms domains.Jan 01, 2021

In this trial cannabis induced a clinical remission in 50% of patients with long standing Crohn's disease with 80% nonresponse or intolerance to anti–TNF-α treatment.Sep 30, 2013

Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.Feb 10, 2019

Long-term cannabidiol treatment in patients with Dravet syndrome.Dec 22, 2018

Observations from this study suggest that cannabis use is associated with lower prevalence of NAFLD.Dec 31, 2016

Orally administered cannabis extract may provide a therapeutic option to other drugs in the treatment of spasticity in patients with multiple sclerosisAug 01, 2004

Parents' reports suggest that cannabidiol may improve autism spectrum disorder comorbidity symptoms.Dec 31, 2017

Prolonged CBD treatment appears to have promising therapeutic effects for improving psychological symptoms and cognition in regular cannabis users.Dec 31, 2017

Purified pharmaceutical CBD may be an effective and safe adjunctive therapy in refractory epileptic spasms.Mar 09, 2020

Safety and tolerability of cannabidiol in Parkinson disease.Dec 31, 2019

Sativex is safe and well tolerated in patients with HD, with no severe adverse events or clinical worsening. May 08, 2016

Tetrahydrocannabivarin could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.Aug 28, 2016

Cannabinoids

View the Evidence:
697 Abstracts with Cannabinoids Research