Cannabinoids

Name	AC	CK
Multiple Sclerosis	40	197
Epilepsy	34	158
Inflammation	40	75
Neuropathic Pain	12	75
Cancers: All	36	55
Epilepsy: Childhood	6	53
Inflammatory Bowel Diseases	13	46
Anxiety	12	43
Seizures	8	42
Stroke	2	40
Stroke: Attenuation/Recovery	6	39
Pain	6	35
Dravet syndrome	5	33
Anxiety Disorders	8	29
Chronic Pain	8	27
Huntington Disease	10	27
Glioma	16	26
Morphine Tolerance/Dependence	4	26
Neurodegenerative Diseases	19	26
Tourette Syndrome	4	26
Breast Cancer	16	25
Diabetes Mellitus: Type 2	4	25
Parkinson's Disease	11	25
Amyotrophic lateral sclerosis (ALS)	4	24
Brain Inflammation	16	23
Schizophrenia	10	23
Alzheimer's Disease	17	22
Depression	11	22
Muscle Spasticity	3	22
Autism Spectrum Disorders	3	21
Marijuana Addiction/Withdrawal	3	21
Acne	2	20
Hypoglycemia	1	20
Opioid Tolerance/Dependence	1	20
Post-Traumatic Stress Disorders (PTSD)	8	20
Glioblastoma Multiforme	7	19
Stroke: Ischemic	4	19
Memory Disorders	5	18
Oxidative Stress	11	18
Sleep Disorders	4	17
Hyperalgesia	6	16
Lung Cancer	11	16
Nonalcoholic fatty liver disease (NAFLD)	3	16
Brain Ischemia	7	15
Colitis	7	15
Dry Skin	1	15
Ulcerative Colitis	2	15
Brain Cancer	3	14
HIV Infections	4	14
Lipopolysaccharide-Induced Toxicity	9	14
Spinal Cord Injuries	3	14
Brain Damage: Hypoxic Ischemic Insult	6	13
Brain: Microglial Activation	6	13
Glioblastoma	7	13
Insomnia	2	13
Obsessive-Compulsive Disorder	3	13
Psychoses	4	13
Bladder Dysfunction	2	12
Cancer Metastasis	9	12
Epileptic Seizures	2	12
Hypertension	2	12
Amyotrophic Lateral Sclerosis	7	11
Colon Cancer	7	11
Endocannabinoid Disorders	2	11
Lennox-Gastaut Syndrome	2	11
Astrocytoma	4	10
Attention Deficit Hyperactivity Disorder	1	10
Brachial Plexus Neuropathies	1	10
Delirium: Drug-Induced	1	10
Impairment: Driving Related	1	10
Organ Transplantation: Kidney	1	10
Overactive Bladder	1	10
Pancreatitis: Chronic	1	10
Peripheral Nerve Diseases	1	10
Prostate Cancer	8	10
Quality of Life: Poor	1	10
Social Anxiety Disorder (SAD)	1	10
Sturge-Weber Syndrome	1	10
Tuberous Sclerosis	1	10
Vaccine-induced Toxicity	1	10
Cerebral Ischemia	4	9
Chemotherapy-Induced Toxicity: Cisplatin	4	9
Allodynia	4	8
Breast Cancer: Triple Negative	6	8
Cardiovascular Diseases	3	8
Obesity	4	8
Skin Cancer	5	8
Traumatic Memory Formation	4	8
Dementia	4	7
Endocannabinoid System	7	7
Glaucoma	4	7
Lymphoma	3	7
Melanoma	4	7
Middle Cerebral Artery Occlusion (MCAO)	4	7
Colorectal Cancer	4	6
Myocardial Infarction	3	6
Alcoholic Liver Disease	1	5
Asthma	3	5
Diabetes Mellitus: Type 1: Prevention	3	5
Diabetic Complications	3	5
Drug Abuse	3	5
Gastrointestinal Inflammation	2	5
Psychiatric Disorder: Conditioned Fear	3	5
Psychiatric Disorders	4	5
Acute Myeloid Leukemia	2	4
Bladder Cancer	3	4
Brain Damage	3	4
Brain: Oxidative Stress	2	4
Cachexia	3	4
Cancer: Pain	3	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	4
Colon Cancer: Prevention	2	4
Diabetes Mellitus: Type 1	2	4
Diabetes: Cataract	2	4
Diabetic Neuropathies	1	4
Emesis	1	4
Endotoxemia	2	4
Eye Damage	1	4
Iron Overload	2	4
Liver Cancer	3	4
Metabolic Syndrome X	1	4
Myocardial Ischemia	2	4
Osteoarthritis	3	4
Pancreatic Cancer	4	4
Vomiting	1	4
Aging	2	3
Alcohol Toxicity	2	3
Arthritis	2	3
Astrocytoma: Grade IV	1	3
Autism	2	3
Autoimmune Diseases	2	3
Chemotherapy and Radiation Toxicity	2	3
Chemotherapy-Induced Nausea	3	3
Drug Addiction	2	3
Encephalomyelitis	2	3
Epidermolysis Bullosa	1	3
Epilepsy: Infant	1	3
Epilepsy: Malignant Migrating Partial Seizures	1	3
Febrile Seizures	1	3
Fibrosis	2	3
Gliomas	2	3
Neuroblastoma	2	3
Psychotic Disorders	2	3
Thyroid Cancer	2	3
Aging: Brain	1	2
Alcohol Withdrawal	1	2
Amphetamine Addiction/Withdrawal	1	2
Appetite Disorders: Loss/Lack of	1	2
Arteriosclerosis	1	2
Bipolar Disorder	1	2
Bone Fractures	1	2
Brain Edema	1	2
Brain Injury: Traumatic	1	2
Breast Cancer: Lung Metastasis	1	2
Breast Cancer: Metastatic	1	2
Breast Cancer: Prevention	1	2
Cachexia: Cancer	2	2
Cachexia: Chemotherapy Induced	1	2
Cardiac Arrhythmias	1	2
Cardiomyopathy	1	2
Cerebral Hypoperfusion	1	2
Chemotherapy-Induced Toxicity: Oxaliplatin	1	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Chemotherapy-Induced Toxicity: Vincristine	1	2
Cocaine Toxicity	1	2
Cognitive Decline/Dysfunction	1	2
Degenerative Disk Disease	1	2
Depression	1	2
Depressive Disorder	1	2
Dermatitis	1	2
Dermatitis: Contact	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Memory Problems	1	2
Diabetic Neuropathy	1	2
Diabetic Retinopathy	1	2
Endometrial Cancer	1	2
Endothelial Dysfunction	1	2
Epilepsy: Drug-Induced	1	2
Fatty Liver	1	2
Friedreich Ataxia	1	2
Fulminant Hepatic Failure	1	2
Gastrointestinal Diseases	1	2
Gastroschisis	1	2
Headache	2	2
Heart Attack	1	2
Hepatic Encephalopathy	1	2
Hepatitis C	2	2
High Fat Diet	1	2
Hypersensitivity	1	2
Hypersensitivity: Type IV	1	2
Infant Neurological Development	1	2
Inflammation: Neutrophil-Mediated	1	2
Insulin Resistance	1	2
Interstitial Lung Diseases	1	2
Ischemia	1	2
Leukemia	2	2
Liver Damage	1	2
Liver Failure: Acute	1	2
Liver Injury: Ischemia/reperfusion	1	2
Malaria	1	2
Memory Disorders: Drug-Induced	1	2
Metabolic Diseases	1	2
Mitochondrial Dysfunction	1	2
Multiple Myeloma	2	2
Muscle Soreness	1	2
Myocarditis: Autoimmune	1	2
Neonatal Stroke	1	2
Neuralgia	1	2
Periodontitis	1	2
Prion Diseases	1	2
Psoriasis	2	2
Rhabdomyosarcoma	1	2
Sciatic Nerve Crush Injury	1	2
Sepsis	1	2
Spinal Cord Inflammation	1	2
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	2
Tardive Dyskinesia	1	2
Traumatic Brain Injury	1	2
Tremor	1	2
Urinary Bladder Diseases	1	2
Uveitis	1	2
AIDS	1	1
Acquired Immunodeficiency Syndrome	1	1
Acute T cell Leukemias	1	1
Alcohol Addiction	1	1
Allergic Airway Diseases	1	1
Anorexia	1	1
Appetite Disorders	1	1
Atherosclerosis	1	1
Bone Diseases	1	1
Cancers: Drug Resistant	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Infection	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Central Nervous System Diseases	1	1
Cervical Cancer	1	1
Cirrhosis	1	1
Clostridium Infections	1	1
Cough	1	1
Diabetes: Cognitive Dysfunction	1	1
Ebola Virus Infections	1	1
Gastric Cancer	1	1
Herpes Simplex Virus Type 2	1	1
Herpes: Kaposi-Associated	1	1
Hydrogen Peroxide Induced Toxicity	1	1
Immune Disorders	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Influenza	1	1
Irritable Bowel Syndrome	1	1
Kaposi Disease	1	1
Kidney Cancer	1	1
Kidney Damage	1	1
Leishmaniasis	1	1
Leukemia: T-cell acute Lymphoblastic	1	1
Liver Fibrosis	1	1
Mood Disorders	1	1
Nausea: Chemotherapy-Induced	1	1
Oral Cancer	1	1
Oral Mucositis	1	1
Peripheral Neuropathies	1	1
Prostate: PSA Doubling	1	1
Pseudomonas aeruginosa	1	1
Rheumatoid Arthritis	1	1
Skin Diseases	1	1
Testicular Cancer	1	1
Tobacco Addiction/Withdrawal	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Anti-Inflammatory Agents	101	250
Neuroprotective Agents	106	236
Anticonvulsants	39	214
Analgesics	36	146
Apoptotic	65	99
Antiproliferative	57	92
Anti-Anxiety Agents	17	62
Tumor Necrosis Factor (TNF) Alpha Inhibitor	22	43
Antioxidants	24	37
Immunomodulatory	17	36
Antineoplastic Agents	22	31
Vasodilator Agents	5	31
Angiogenesis Inhibitors	14	29
Anti-metastatic	20	29
Antidepressive Agents	11	24
Antinoceceptive	6	22
Hypoglycemic Agents	2	22
Cyclooxygenase 2 Inhibitors	6	19
Chemotherapeutic	11	17
Immunosuppressive Agents	6	17
Anti-Apoptotic	10	16
Hepatoprotective	7	15
NF-kappaB Inhibitor	9	15
Antihypertensive Agents	3	13
Cardioprotective	7	13
Interleukin-6 Downregulation	7	13
Antispasmodic	2	12
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	12
Vascular Endothelial Growth Factor Inhibitors	3	12
Antipsychotic Agents	7	11
Anxiolytic	2	11
Cell cycle arrest	8	11
Chemoprotective Agents	5	11
Anti-Tumor	5	10
Anticarcinogenic Agents	7	10
Autophagy Up-regulation	8	10
Chemopreventive	6	10
GABA Modulators	1	10
Interleukin-1 beta downregulation	6	10
Interferon Gamma Reducer	5	9
Chemosensitizer	5	7
Neurogenesis	5	7
Brain-derived neurotrophic factor modulator	3	6
Nitric Oxide Inhibitor	3	6
P38 Mitogen-Activated Protein Kinase Modulator	2	6
Superoxide Dismutase Up-regulation	2	6
Vascular Cell Adhesion Molecule-1 Inhibitor	2	6
Anti-Angiogenic	5	5
Appetite Stimulants	3	5
Cannabinoid Receptor Antagonist/Inverse Agonist	3	5
Hypolipidemic	1	5
Caspase-3 Activation	3	4
Enzyme Inhibitors	2	4
Interleukin-10 downregulation	2	4
Interleukin-17 downregulation	3	4
Interleukin-4 downregulation	2	4
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	4
Osteoprotective	3	4
Prostaglandin PGE2 downregulation	2	4
Vascular Endothelial Growth Factor A Inhibitor	2	4
Vascular Endothelial Growth Factor Regulator	2	4
Gastrointestinal Agents	3	3
Immunomodulatory: Th17 downregulation	2	3
Interleukin-8 downregulation	2	3
Neuritogenic	2	3
Radiosensitizer	2	3
Renoprotective	2	3
Aldose reductase inhibitor	1	2
Anti-Androgen	1	2
Anti-Bacterial Agents	2	2
Anti-Fibrotic	2	2
Anti-atherogenic	1	2
Calcium Channel Blockers	1	2
Cyclooxygenase Inhibitors	1	2
Enzyme Activators	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Gastroprotective	2	2
Glycine Agents	1	2
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Immunomodulatory: T-Cell down-regulation	1	2
Interleukin-10 upregulation	1	2
Interleukin-12 downregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-5 downregulation	1	2
Intracellular adhesion molecule-1 (ICAM-1)	1	2
Malondialdehyde Down-regulation	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	2
MicroRNA modulator	2	2
Neuroplasticity enhancement	1	2
Pancreato Protective Agents	1	2
Prophylactic Agents	1	2
Redox Modulator	1	2
Sedative effects	1	2
Topoisomerase II Inhibitor	2	2
Vanilloid Receptor-1 Modulator	1	2
interleukin-13 down-regulation	1	2
Anti-Cachexic Agents	1	1
Anti-Proliferative	1	1
Anti-Psychotic	1	1
Antifungal Agents	1	1
Antiviral Agents	1	1
Caspase-8 activation	1	1
Caspase-9 Activation	1	1
Cyclooxygenase 1 Inhibitor	1	1
Cytotoxic	1	1
Interleukin-2 upregulation	1	1
NADPH Oxidase Inhibitors	1	1
Neuroimmunomodulation	1	1
Nrf2 activation	1	1
Paraptosis	1	1
Photoprotective	1	1
Transient receptor potential vanilloid type-2 activation	1	1
Wnt/β-catenin signaling pathway modulation	1	1
apoptosis	1	1

[+]

A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.Nov 02, 2018

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Pubmed Data : Drugs. 2018 Nov 3. Epub 2018 Nov 3. PMID: 30390221

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2017 ;8:81. Epub 2017 Feb 24. PMID: 28286481

Article Published Date : Dec 31, 2016

Study Type : Meta Analysis, Review

Additional Links

Substances : Cannabidiol

Diseases : Stroke

Pharmacological Actions : Vasodilator Agents

[+]

A case report of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.Jul 31, 2019

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Pubmed Data : Pharmacol Res Perspect. 2016 Apr ;4(2):e00220. Epub 2016 Mar 5. PMID: 27069631

Article Published Date : Mar 31, 2016

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Dravet syndrome, Endocannabinoid Disorders

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Endocannabinoid System

[+]

Cannabidiol could reduce severe behavioural problems in children and adolescents with intellectual disability. May 31, 2020

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Pubmed Data : Br J Clin Pharmacol. 2020 Jun 1. Epub 2020 Jun 1. PMID: 32478863

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Epilepsy Behav. 2018 Aug 9. Epub 2018 Aug 9. PMID: 30100226

Article Published Date : Aug 08, 2018

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Seizures

Pharmacological Actions : Anticonvulsants

[+]

Cannabidiol in the treatment of post-traumatic stress disorder.Dec 12, 2018

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Pubmed Data : J Altern Complement Med. 2018 Dec 13. Epub 2018 Dec 13. PMID: 30543451

Article Published Date : Dec 12, 2018

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Post-Traumatic Stress Disorders (PTSD)

Additional Keywords : Significant Treatment Outcome

[+]

Click here to read the entire abstract

Pubmed Data : N Engl J Med. 2017 05 25 ;376(21):2011-2020. PMID: 28538134

Article Published Date : Jan 24, 2017

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Dravet syndrome

Pharmacological Actions : Anticonvulsants

Additional Keywords : Significant Treatment Outcome

[+]

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

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Pubmed Data : Epilepsy Behav. 2013 Dec ;29(3):574-7. PMID: 24237632

Anti Therapeutic Actions : Vaccination: HPV (Gardasil)

[+]

CBD has anxiolytic properties in human volunteers submitted to a stressful situation.Dec 31, 1992

Click here to read the entire abstract

Pubmed Data : J Psychopharmacol. 1993 Jan ;7(1 Suppl):82-8. PMID: 22290374

Article Published Date : Dec 31, 1992

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Anxiety

Pharmacological Actions : Anti-Anxiety Agents

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Clin Gastroenterol Hepatol. 2013 Oct ;11(10):1276-1280.e1. Epub 2013 May 4. PMID: 23648372

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Substances : Cannabinoids , Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs, Significant Treatment Outcome

[+]

Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.Feb 10, 2019

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Pubmed Data : Eur Neurol. 2016 Oct 13 ;76(5-6):216-226. Epub 2016 Aug 13. PMID: 27732980

Article Published Date : Oct 12, 2016

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Multiple Sclerosis

[+]

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

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Pubmed Data : Cannabis Cannabinoid Res. 2017 ;2(1):167-182. Epub 2017 Jul 1. PMID: 29082314

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

[+]

The results reported here are very promising and indicate that CBD-enriched cannabis extract may ameliorate multiple autism spectrum disorders symptoms.Dec 31, 2018

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Pubmed Data : Front Neurol. 2019 ;10:1145. Epub 2019 Oct 31. PMID: 31736860

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Autism Spectrum Disorders

Pharmacological Actions : Neuroprotective Agents

[+]

Additional Keywords : Anti-Inflammatory Agents, Cannabinoids, Immunosuppressive Agents, Inflammation, Pancreatitis: Chronic

[+]

These results suggest that CBD has anxiolytic properties.Jan 31, 2004

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Pubmed Data : Proc Natl Acad Sci U S A. 1998 Jul 7 ;95(14):8375-80. PMID: 9653194

Article Published Date : Jul 06, 1998

Study Type : Human In Vitro

Additional Links

Substances : Anandamide, Cannabinoids

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Cannabinoid Receptors, Dose Response

[+]

Cannabidiol causes vasorelaxation of the human mesenteric artery.Aug 31, 2015

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Pubmed Data : Cardiovasc Res. 2015 Sep 1 ;107(4):568-78. Epub 2015 Jun 19. PMID: 26092099

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Pubmed Data : J Pharm Pharmacol. 2004 Mar ;56(3):291-7. PMID: 15025853

Article Published Date : Feb 29, 2004

Study Type : Human In Vitro

Additional Links

Substances : Cannabidiol, Cannabinoids

[+]

Phytocannabinoids could be efficient and safe novel treatments in the management of cutaneous inflammations.Apr 19, 2016

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Pubmed Data : Exp Dermatol. 2016 Apr 20. Epub 2016 Apr 20. PMID: 27094344

Article Published Date : Apr 19, 2016

Study Type : Human In Vitro

Additional Links

Substances : Cannabidiol, Cannabidivarin, Cannabigerol , Cannabigerovarin , Cannabinoids

Diseases : Acne, Dry Skin

Pharmacological Actions : Anti-Inflammatory Agents

[+]

The present data suggest that targeting CB(1)/CB(2) may have therapeutic potential for the treatment of mantle cell lymphoma.Oct 31, 2006

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Pubmed Data : Mol Pharmacol. 2006 Nov ;70(5):1612-20. Epub 2006 Aug 25. PMID: 16936228

Article Published Date : Oct 31, 2006

Study Type : Human In Vitro

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Lymphoma

Pharmacological Actions : Apoptotic, P38 Mitogen-Activated Protein Kinase Modulator

Additional Keywords : Selective Cytotoxicity

[+]

The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.Mar 31, 2006

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Pubmed Data : Eur J Pharmacol. 2006 Aug 7;542(1-3):100-5. Epub 2006 May 20. PMID: 16781706

Article Published Date : Aug 07, 2006

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Amyotrophic Lateral Sclerosis

Pharmacological Actions : Neuroprotective Agents

[+]

A cannabis extract with high content in cannabidiol attenuated chemically-induced intestinal inflammation.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:341. Epub 2016 Aug 4. PMID: 27757083

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabinoids , Cannabis

Diseases : Colitis, Gastrointestinal Inflammation, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Plant Extracts

[+]

[+]

Activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine.Dec 31, 2014

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 6. Epub 2018 Jun 6. PMID: 29885468

Article Published Date : Jun 05, 2018

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Avidekel cannabis extracts and cannabidiol are as efficient as copaxone in suppressing experimental autoimmune encephalomyelitis in mice.Oct 04, 2018

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Pubmed Data : Inflammopharmacology. 2018 Oct 5. Epub 2018 Oct 5. PMID: 30291491

Article Published Date : Oct 04, 2018

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

Additional Keywords : Natural Substances Versus Drugs

[+]

Additional Keywords : Cannabidiol, Middle Cerebral Artery Occlusion (MCAO), Neuroprotective Agents

[+]

Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway. Jun 19, 2020

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Pubmed Data : Neuropharmacology. 2020 Jun 20:108156. Epub 2020 Jun 20. PMID: 32574650

Article Published Date : Jun 19, 2020

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors.Mar 05, 2020

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Pubmed Data : Pharmacol Res. 2020 Mar 6 ;156:104749. Epub 2020 Mar 6. PMID: 32151683

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Pubmed Data : J Clin Invest. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31503547

Article Published Date : Sep 09, 2019

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Angelman Syndrome, Epilepsy

Pharmacological Actions : Anticonvulsants

[+]

Click here to read the entire abstract

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Pubmed Data : Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID: 20053780

Article Published Date : Dec 31, 2009

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Cancer Metastasis, Glioblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Cannabinoid Receptors, Natural Substance Synergy

[+]

Cannabidiol exhibits an anticonvulsive effect in the rats with chronic epilepsy.Dec 31, 2014

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Pubmed Data : Int J Clin Exp Med. 2015 ;8(6):8820-7. Epub 2015 Jun 15. PMID: 26309534

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy, Epilepsy: Drug-Induced

Pharmacological Actions : Anticonvulsants, Neuroprotective Agents

[+]

Cannabidiol exhibits an antipsychotic-like profile without inducing extrapyramidal-like effects.Apr 10, 2005

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Pubmed Data : Eur J Pharmacol. 2005 Apr 11 ;512(2-3):199-205. PMID: 15840405

Article Published Date : Apr 10, 2005

Study Type : Animal Study

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Substances : Cannabidiol

Pharmacological Actions : Antipsychotic Agents

Additional Keywords : Antipsychotic Agents, Cannabidiol, Natural Substances Versus Drugs

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Pubmed Data : Br J Pharmacol. 2008 Jul ;154(5):1001-8. Epub 2008 May 12. PMID: 18469842

Article Published Date : Jun 30, 2008

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Enzyme Inhibitors

Problem Substances : Croton oil

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Cannabidiol may represent a promising new protective strategy against cisplatin-induced nephrotoxicity.Feb 28, 2009

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Pubmed Data : J Mol Med (Berl). 2012 Aug ;90(8):925-34. Epub 2012 Jan 10. PMID: 22231745

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Cannabidiol treatment significantly reduces the incidence of diabetes in NOD mice.Feb 28, 2006

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Pubmed Data : Autoimmunity. 2006 Mar ;39(2):143-51. PMID: 16698671

Article Published Date : Feb 28, 2006

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Diabetes Mellitus: Type 1: Prevention

Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Risk Reduction, Significant Treatment Outcome

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cannabidiol was able to produce a significant antitumor activity both in vitro and in vivo.Feb 29, 2004

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Pubmed Data : Neuropharmacology. 2008 Dec ;55(8):1280-6. Epub 2008 Jun 27. PMID: 18634812

Article Published Date : Nov 30, 2008

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Hypertension, Middle Cerebral Artery Occlusion (MCAO)

Pharmacological Actions : Neuroprotective Agents

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Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.Jan 17, 2019

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Pubmed Data : Cancer Lett. 2019 Jan 18 ;447:12-23. Epub 2019 Jan 18. PMID: 30660647

Article Published Date : Jan 17, 2019

Study Type : Animal Study, In Vitro Study

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Substances : Cannabidiol

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic

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Cannabidiol-transdermal delivery has an anti-inflammatory effect in a murine model.Dec 11, 2003

Pubmed Data : Nat Chem Biol. 2011 May;7(5):296-303. Epub 2011 Apr 3. PMID: 21460829

Article Published Date : May 01, 2011

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Pain

Pharmacological Actions : Analgesics, Glycine Agents

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Cannabinoid receptor agonists HU210 and Delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis.Jun 30, 2009

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Pubmed Data : Mol Cancer Ther. 2009 Jul ;8(7):1838-45. Epub 2009 Jun 9. PMID: 19509271

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Pubmed Data : FASEB J. 2003 Mar ;17(3):529-31. Epub 2003 Jan 2. PMID: 12514108

Article Published Date : Feb 28, 2003

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Cancers: All, Gliomas

Pharmacological Actions : Angiogenesis Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Regulator

Additional Keywords : Disease Regression

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Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.Nov 30, 2006

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Pubmed Data : FASEB J. 2006 Dec ;20(14):2633-5. Epub 2006 Oct 25. PMID: 17065222

Article Published Date : Nov 30, 2006

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Melanoma

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Cannabinoid Receptors, Selective Cytotoxicity

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Cannabis extracts have therapeutic potential to slow multiple sclerosis progression and repair the central nervous system.Jun 30, 2015

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Pubmed Data : Br J Pharmacol. 2015 Jul ;172(14):3579-95. Epub 2015 May 20. PMID: 25857324

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Multiple Sclerosis

Pharmacological Actions : Immunomodulatory

Additional Keywords : Plant Extracts

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Cannabis may provide support as a novel disease-modifying therapy in ALS.Aug 31, 2014

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Pubmed Data : CNS Neurosci Ther. 2014 Sep ;20(9):809-15. Epub 2014 Apr 7. PMID: 24703394

Article Published Date : Aug 31, 2014

Study Type : Transgenic Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Amyotrophic lateral sclerosis (ALS)

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Cannabis sativa extract has an antihyperalgesic effect in a rat model of neuropathic pain.Jul 31, 2008

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Pubmed Data : Phytother Res. 2008 Aug ;22(8):1017-24. PMID: 18618522

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CBD induces antidepressant-like effects comparable to those of imipramine. Dec 31, 2009

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Pubmed Data : Br J Pharmacol. 2010 Jan ;159(1):122-8. Epub 2009 Dec 4. PMID: 20002102

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Pubmed Data : Neuropharmacology. 2013 Aug ;71:282-91. Epub 2013 Apr 12. PMID: 23587650

Article Published Date : Jul 31, 2013

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabinoids

Diseases : Brain Damage: Hypoxic Ischemic Insult, Brain Ischemia

Pharmacological Actions : Neuroprotective Agents

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Neurodegenerative diseases linked directly to mitochondrial malfunction may benefit greatly from CBD-based medicines.Feb 17, 2009

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Pubmed Data : J Neurosci. 2009 Feb 18 ;29(7):2053-63. PMID: 19228959

Article Published Date : Feb 17, 2009

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Friedreich Ataxia, Huntington Disease, Mitochondrial Dysfunction , Neurodegenerative Diseases

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

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Oral treatment with a low dose of THC inhibits atherosclerosis progression in this mouse model.Apr 06, 2005

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Pubmed Data : Nature. 2005 Apr 7 ;434(7034):782-6. PMID: 15815632

Article Published Date : Apr 06, 2005

Study Type : Animal Study

Additional Links

Substances : Cannabinoids , Delta-tetrahydrocannabinol (THC)

Diseases : Arteriosclerosis, Inflammation

Pharmacological Actions : Anti-atherogenic, Anti-Inflammatory Agents, Interferon Gamma Reducer, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Our results indicate that CBD exhibits neuroprotective effects in a cerebral malaria model and might be useful as an adjunctive therapy to prevent neurological symptoms.Mar 18, 2015

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Pubmed Data : Neuroscience. 2015 Mar 19 ;289:166-80. Epub 2015 Jan 13. PMID: 25595981

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Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 23. Epub 2016 Nov 23. PMID: 27889412

Article Published Date : Nov 22, 2016

Study Type : Animal Study

Additional Links

Substances : Cannabidiol

Diseases : Brain Inflammation , Brain Ischemia

Pharmacological Actions : Neuroplasticity enhancement, Neuroprotective Agents

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Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma.Mar 30, 2020

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Pubmed Data : Oncotarget. 2020 Mar 31 ;11(13):1141-1156. Epub 2020 Mar 31. PMID: 32284791

Article Published Date : Mar 30, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Lymphoma

Pharmacological Actions : Cytotoxic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

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Tetrahdrocannabivarin has therapeutic potential for ameliorating some of the negative, cognitive and positive symptoms of schizophrenia.Feb 28, 2015

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis, Delta-tetrahydrocannabinol (THC)

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents

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View the Evidence: 628 Abstracts with Cannabinoids Research

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A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.Nov 02, 2018

A systematic review and meta-analysis off the effects of cannabinoids in Amyotrophic lateral sclerosis murine models.Dec 05, 2018

Adjunctive CBD resulted in a greater reduction in convulsive seizure frequency.Feb 09, 2020

Cannabinoids may have possible therapeutic properties for the management of the multiple sclerosis.Nov 19, 2010

Cannabinoids significantly reduced infarct volume and improve functional outcome in experimental stroke models.Feb 28, 2015

Selective cannabinoids provide a small analgesic benefit in patients with chronic neuropathic pain.May 18, 2017

The median effective dose of morphine administered in combination with THC is 3.6 times lower than of morphine alone.Mar 21, 2017

This meta-analysis and systematic review has highlighted the haemodynamic effects of CBD.Dec 31, 2016

A case report of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.Jul 31, 2019

A single dose of cannabidiol reduces blood pressure in healthy volunteers.Jun 14, 2017

A tetrahydrocannabinol:cannabidiol (THC:CBD) extract is efficacious for relief of pain in patients with advanced cancer pain not fully relieved by strong opioids.Jul 01, 2009

Acute cannabidiol administration at a dose of 300 mg decreased anxiety in patients with Parkinson's disease.Jan 06, 2020

Add-on cannabidiol may be an efficacious long-term treatment option for treatment-resistant epilepsies.Jul 11, 2018

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis.Aug 21, 2019

Cannabidiol could be useful in Dravet syndrome treatments. Mar 31, 2016

Cannabidiol could reduce severe behavioural problems in children and adolescents with intellectual disability. May 31, 2020

Cannabidiol for treating drug-resistant epilepsy in children.Aug 12, 2018

Cannabidiol has antipsychotic properties which balance out the psychotomimetic effects of THC in cannabis.Apr 01, 2008

Cannabidiol improves frequency and severity of seizures and reduces adverse events.Aug 08, 2018

Cannabidiol in the treatment of post-traumatic stress disorder.Dec 12, 2018

Cannabidiol levels in different strains of cannabis may determine the degree to which THC interferes with memory in users.Oct 01, 2010

Cannabidiol may be an effective and well-tolerated treatment option for patients with refractory seizures in Tuberous sclerosis complex.Sep 30, 2016

Cannabidiol may hold benefit for anxiety-related disorders. Dec 31, 2018

Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.Dec 22, 2015

Cannabidiol reduces anxiety in social anxiety disorder through modulating the limbic and paralimbic brain areas. Sep 09, 2010

Cannabidiol resulted in a greater reduction in convulsive-seizure frequency among patients with Dravet syndrome.Jan 24, 2017

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.Jan 05, 2016

Cannabinoids may have therapeutic value in the treatment of tics in Tourette syndrome. Oct 01, 2003

Cannabis and cannabinoids in cancer pain management.May 31, 2020

Cannabis could be potentially beneficial reduction in systemic inflammation and immune activation in the context of antiretroviral-treated HIV infection.Feb 16, 2018

Cannabis extracts can be a useful and safe option for patients with MS with moderate to severe spasticity resistant to common antispastic drugs.May 08, 2016

Cannabis extracts can be considered an alternative in patients with spasticity associated with chronic spinal cord injury.Sep 30, 2017

Cannabis in ASD patients appears to be well tolerated, safe and effective option to relieve symptoms associated with ASD.Jan 16, 2019

Cannabis is well-tolerated and efficacious in the treatment of neuropathic pain from brachial plexus avulsion.Dec 01, 2004

Cannabis may have therapeutic value in the treatment of Tourette syndrome.Dec 01, 1998

Cannabis-based medicine is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain and is mostly well tolerated.Sep 27, 2005

Cannabis-based medicine may represent a useful new agent for treatment of the symptomatic relief of spasticity in MS.Feb 28, 2007

CBD could be beneficial for the treatment of brain tumor-related epilepsy.Oct 23, 2017

CBD enriched hemp oil could be beneficial in girls with adverse drug effects following human papillomavirus (HPV) vaccine.Jan 31, 2017

CBD has anxiolytic properties in human volunteers submitted to a stressful situation.Dec 31, 1992

CBD may be effective, safe and well tolerated for the treatment of the psychosis in Parkinson's disease.Oct 31, 2009

CBD restores excitability and morphological impairment in epileptic models to pre-epilepsy control levels.Mar 24, 2018

CBD was found to have potential benefits as add-on therapy for refractory childhood epilepsies.Mar 07, 2018

CBD-rich botanical extract may be beneficial for symptomatic treatment of ulcerative colitis.Mar 09, 2018

Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay.Feb 28, 2018

Delta-tetrahydrocannabinol (THC) and cannabidiol have therapeutic value in the management of spasticity associated wtih multiple sclerosis. Aug 01, 1996

Delta9-tetrahydrocannabinol administration led to the inhibition of the VEGF Pathway in Two Patients with Glioblastoma Multiforme.Aug 14, 2004

Drivers under the influence of synthetic cannabinoids were more frequently impaired with confusion, disorientation, and incoherent, slurred speech than drivers under the influence of marijuana in this population evaluated by drug recognition experts.Dec 31, 2015

Dronabinol is a safe long-term treatment option for neuropathic pain patients.Oct 25, 2017

Effectiveness of cannabidiol in a prospective cohort of children with drug-resistant epileptic encephalopathy.Jun 05, 2020

Effects of cannabidiol on brain excitation and inhibition systems.Feb 05, 2019

Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

In this trial cannabis induced a clinical remission in 50% of patients with long standing Crohn's disease with 80% nonresponse or intolerance to anti–TNF-α treatment.Sep 30, 2013

Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.Feb 10, 2019

Long-term cannabidiol treatment in patients with Dravet syndrome.Dec 22, 2018

Observations from this study suggest that cannabis use is associated with lower prevalence of NAFLD.Dec 31, 2016

Orally administered cannabis extract may provide a therapeutic option to other drugs in the treatment of spasticity in patients with multiple sclerosisAug 01, 2004

Parents' reports suggest that cannabidiol may improve autism spectrum disorder comorbidity symptoms.Dec 31, 2017

Prolonged CBD treatment appears to have promising therapeutic effects for improving psychological symptoms and cognition in regular cannabis users.Dec 31, 2017

Purified pharmaceutical CBD may be an effective and safe adjunctive therapy in refractory epileptic spasms.Mar 09, 2020

Sativex is safe and well tolerated in patients with HD, with no severe adverse events or clinical worsening. May 08, 2016

Tetrahydrocannabivarin could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes.Aug 28, 2016

THC and CBD was effective in select patients with central neuropathic pain and multiple sclerosis.Aug 31, 2007

THC/CBD oromucosal spray has shown to be effective in improving overactive bladder symptoms in multiple sclerosis patients.Oct 18, 2017

THC/CBD spray was beneficial for the majority of patients with PNP associated with diabetes or allodynia.Dec 31, 2014

THC:CBD oromucosal spray provided symptomatic relief of MS spasticity with good tolerability in a relevant number of previously resistant patients.Dec 31, 2014

THC:CBD oromucosal spray provided symptomatic relief of MSS and related troublesome symptoms.Oct 12, 2016

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

The anxiolytic effect of Cannabidiol has a U shaped dose response curve. Dec 31, 2016

The present study confirms the efficacy of cannabinoids in reducing spasticity in patients with multiple sclerosis.Mar 20, 2016

The results indicate that CBD could be a useful option to treat social anxiety.Dec 31, 2018

Cannabinoids

View the Evidence:
628 Abstracts with Cannabinoids Research