Citrus naringin

Name	AC	CK
Osteoporosis	4	25
Brain: Oxidative Stress	1	20
Bisphenol Toxicity	7	13
Diabetic Complications	6	13
Dyslipidemias	2	12
Oxidative Stress	7	12
Diabetes Mellitus: Type 2	6	10
Lipopolysaccharide-Induced Toxicity	6	9
Chemically-Induced Liver Damage	5	8
Diabetes: Oxidative Stress	3	8
Inflammation	6	7
Alzheimer's Disease	3	6
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	6
DNA damage	4	5
HIV Drug-Induced Toxicity	3	5
Lipid Peroxidation	3	5
Neurodegenerative Diseases	4	5
Parkinson's Disease	3	5
Sepsis	3	5
Air Pollution Linked Toxicity	2	4
Anxiety	2	4
Cerebral Ischemia	2	4
Colitis	2	4
Depression	2	4
Ischemia	2	4
Liver Cancer	3	4
Atherosclerosis	2	3
Cancers: All	3	3
Sciatica	2	3
Testicular Injury: Chemical/Metal Induced	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging	1	2
Alcohol Toxicity	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Asthma	1	2
Bone Fractures	1	2
Brain Inflammation	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Cardiovascular Diseases	2	2
Cataract	1	2
Cerebral Hemorrhage	1	2
Cervical Cancer	2	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Doxorubicin	1	2
Colon Cancer	1	2
Colorectal Cancer: Prevention	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetic Nephropathy	1	2
Diabetic Retinopathy	1	2
Diesel Exhaust Particle Toxicity	1	2
Drug Toxicity: Methotrexate	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Drug-Induced Toxicity: Indomethacin	1	2
Dysbiosis	1	2
Endothelial Dysfunction	1	2
Erectile Dysfunction	1	2
Fatigue	1	2
High Fat Diet	1	2
High Fructose Diet	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Hyperalgesia	1	2
Hyperammonemia	1	2
Hyperglycemia	1	2
Hypertension	1	2
Inflammatory Bowel Diseases	1	2
Insulin Resistance	1	2
Intervertebral Disk Displacement	1	2
Liver Cirrhosis	1	2
Lung Injury: Smoke-Induced	1	2
Memory Disorders	1	2
Metabolic Syndrome X	2	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Osteoarthritis	1	2
Osteoarthritis: Knee	1	2
Ovarian Cancer	1	2
Perfluorooctane Sulfonate-Induced Toxicity	1	2
Peripheral Nerve Diseases	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Radiation Induced Illness	1	2
Rheumatoid Arthritis	1	2
Schizophrenia	1	2
Steroid-Induced Toxicity	1	2
Stroke	1	2
Subarachnoid hemorrhage	1	2
Ulcerative Colitis	1	2
Ultraviolet Radiation Induced Damage	2	2
Aging Skin	1	1
Androgen-Induced Diseases	1	1
Bone Diseases	1	1
Cadmium Poisoning	1	1
Cancers: Multi-Drug Resistant	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Chemotherapy-Induced Toxicity: Bleomycin	1	1
Colorectal Cancer	1	1
Dengue	1	1
Fibrosis	1	1
Gastric Cancer	1	1
Gastrointestinal Diseases	1	1
Gastrointestinal Inflammation	1	1
Gingivitis	1	1
Glioblastoma	1	1
Hypoglycemia	1	1
Liver Damage: Drug-Induced	1	1
Liver Steatosis	1	1
Low Back Pain	1	1
Metabolic Diseases	1	1
Obesity	1	1
Osteonecrosis	1	1
Osteoporosis: Male	1	1
Osteosarcoma	1	1
Peridontal Infection	1	1
Prostate Cancer	1	1
Pseudomonas aeruginosa	1	1
Respiratory Diseases	1	1
Scars	1	1
Spinal Cord Injuries	1	1
Thyroid Cancer	1	1
Titanium Toxicity	1	1
Wound Healing	1	1

Name	AC	CK
Antioxidants	32	74
Anti-Inflammatory Agents	32	51
Neuroprotective Agents	17	49
Anti-Apoptotic	20	33
Interleukin-6 Downregulation	17	28
Tumor Necrosis Factor (TNF) Alpha Inhibitor	16	28
Osteoprotective	6	27
Hepatoprotective	13	23
Interleukin-1 beta downregulation	13	19
Apoptotic	10	13
Anticholesteremic Agents	2	12
Antiproliferative	10	12
Renoprotective	6	11
Cardioprotective	6	10
Chemoprotective Agents	5	10
Hypoglycemic Agents	6	9
MicroRNA modulator	5	9
Gastrointestinal Agents	4	8
NF-kappaB Inhibitor	5	8
Cyclooxygenase 2 Inhibitors	5	7
Hypolipidemic	5	7
Cytoprotective	3	6
Pancreato Protective Agents	3	4
Acetylcholinesterase Inhibitor	2	3
Anti-Fibrotic	2	3
Gastroprotective	2	3
Angiogenesis Inducing Agents	1	2
Anti-Anxiety Agents	1	2
Anti-Asthmatic Agents	1	2
Anti-Bacterial Agents	2	2
Anti-atherogenic	1	2
Anticarcinogenic Agents	1	2
Antidepressive Agents	1	2
Cell cycle arrest	2	2
Enzyme Inhibitors	1	2
Genoprotective	2	2
Insulin-releasing	1	2
Interferon Gamma Reducer	1	2
Interleukin-10 upregulation	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Nitric Oxide Inhibitor	1	2
Nrf2 activation	2	2
Photoprotective	2	2
Radioprotective	1	2
Superoxide Dismutase Up-regulation	1	2
Alpha-glucosidase inhibitor	1	1
Angiogenesis Inhibitors	1	1
Anti-Androgen	1	1
Anti-metastatic	1	1
Antihypertensive Agents	1	1
Antineoplastic Agents	1	1
Antiviral Agents	1	1
Autophagy Up-regulation	1	1
Chemopreventive	1	1
Chemosensitizer	1	1
Chemotherapeutic	1	1
Enzyme Inhibitors: Pancreatic Lipase	1	1
Interleukin-18 down-regulation	1	1
Regenerative	1	1
Transforming growth factor beta (TGF-β) inhibitor	1	1

[+]

Naringin had been shown to promote bone formation in OVX rats. Dec 31, 2020

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Dried peel powder of C. kawachiensis had a neuroprotective effect against ischemic brain injury. Apr 03, 2018

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Pubmed Data : Biosci Biotechnol Biochem. 2018 Apr 4:1-9. Epub 2018 Apr 4. PMID: 29618282

Article Published Date : Apr 03, 2018

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Citrus Peel , Fruit: All

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Cerebral Ischemia, Citrus naringin, Citrus Peel, Fruit: All, Neuroprotective Agents

[+]

Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A.Feb 28, 2019

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Pubmed Data : Iran J Basic Med Sci. 2019 Mar ;22(3):315-523. PMID: 31156794

Article Published Date : Feb 28, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Bisphenol Toxicity, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants, Cytoprotective

Problem Substances : Bisphenol A

[+]

Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms.Dec 31, 2020

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Pubmed Data : Neurotoxicology. 2020 Aug 15 ;81:18-33. Epub 2020 Aug 15. PMID: 32810514

Article Published Date : Aug 14, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Bisphenol Toxicity, Brain Inflammation , Hypertension

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

Problem Substances : Bisphenol A

[+]

Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury.Dec 02, 2020

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Pubmed Data : Neuromolecular Med. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31916219

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Pubmed Data : Front Microbiol. 2020 ;11:585066. Epub 2020 Nov 13. PMID: 33281780

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Dysbiosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastrointestinal Agents, Hepatoprotective

[+]

Naringin may become a new method to treat and prevent NSAIDs related intestinal diseases.Dec 14, 2020

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Pubmed Data : Life Sci. 2020 Dec 15 ;266:118909. Epub 2020 Dec 15. PMID: 33333047

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Pubmed Data : Biomed Pharmacother. 2020 Mar 12 ;126:110043. Epub 2020 Mar 12. PMID: 32172062

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:2745352. Epub 2019 Mar 26. PMID: 31049130

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Citrus Peel , Naringenin , Orange

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective

[+]

The present study highlighted the therapeutic potential of naringin against bisphenol A-induced cognitive impairment and oxidative damage.Dec 31, 2018

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Pubmed Data : Int J Mol Cell Med. 2019 ;8(2):141-153. Epub 2019 Oct 25. PMID: 32215265

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Citrus naringin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Problem Substances : Bisphenol A

Adverse Pharmacological Actions : Neurotoxic

[+]

The renoprotective effects of naringin on renal ischemia/reperfusion injury.Feb 15, 2019

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Pubmed Data : Food Chem. 2020 Apr 11 ;326:126785. Epub 2020 Apr 11. PMID: 32438224

Article Published Date : Apr 10, 2020

Study Type : In Vitro Study

Additional Links

Substances : Citrus naringin, Citrus Peel , Hesperidin, neohesperidin

Diseases : Metabolic Syndrome X, Obesity, Oxidative Stress

Pharmacological Actions : Antioxidants, Enzyme Inhibitors: Pancreatic Lipase

[+]

Antiviral activity of four types of bioflavonoid against dengue virus type-2.Dec 27, 2011

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Pubmed Data : Virol J. 2011 Dec 28 ;8:560. Epub 2011 Dec 28. PMID: 22201648

Article Published Date : Dec 27, 2011

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Pubmed Data : Molecules. 2020 Jul 29 ;25(15). Epub 2020 Jul 29. PMID: 32751373

Article Published Date : Jul 28, 2020

Study Type : In Vitro Study

Additional Links

Substances : Citrus naringin, Naringenin , Quercetin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Fighting bisphenol A-induced male infertility: The power of antioxidants. Feb 14, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Feb 15 ;10(2). Epub 2021 Feb 15. PMID: 33671960

Article Published Date : Feb 14, 2021

Study Type : Review

Additional Links

Substances : Citrus naringin, Lycopene, Melatonin, NAC (N-acetyl-L-cysteine), Quercetin, Selenium, Vitamin C, Vitamin E

Diseases : Bisphenol Toxicity, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Antioxidants

Problem Substances : Bisphenol A

[+]

Induction of human hepatocellular carcinoma HepG2 cell apoptosis by naringin.Dec 31, 2015

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Naringin is an antioxidant that appears to be efficacious in alleviating metabolic syndrome.Dec 31, 2018

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View the Evidence: 135 Abstracts with Citrus naringin Research

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Naringin had been shown to promote bone formation in OVX rats. Dec 31, 2020

This supports the available scientific evidence on the beneficial role of naringin in the management of various neurological ailments.Sep 30, 2017

Naringin is a potential therapeutic agent which could play an important role in the management of metabolic disorders.Jun 08, 2020

Naringin protects against high glucose-induced human endothelial cell injury.Dec 31, 2016

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

A dihydroflavonoid naringin extends the lifespan of C. elegans and delays the progression of aging-related diseases.Dec 31, 2019

Colon targeting of naringin for enhanced cytoprotection against indomethacin-induced colitis.Dec 31, 2019

Dried peel powder of C. kawachiensis had a neuroprotective effect against ischemic brain injury. Apr 03, 2018

Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A.Feb 28, 2019

Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms.Dec 31, 2020

Naringin alleviates atherosclerosis in ApoE -/- mice.Nov 10, 2020

Naringin alleviates early brain injury after experimental subarachnoid hemorrhage.Jun 30, 2017

Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.Jul 10, 2019

Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. May 26, 2020

Naringin also regulates endothelial cell function and promotes angiogenesis to exert its anti‑osteoporotic effect.Nov 30, 2017

Naringin ameliorated oxidative stress and nucleoside reverse transcriptase inhibitors-induced mitochondrial damage.Dec 31, 2015

Naringin ameliorates endothelial dysfunction in fructose-fed rats.Feb 28, 2018

Naringin and bone marrow mesenchymal stem cells repair articular cartilage defects.Oct 31, 2020

Naringin and vitamin C demonstrates antihyperglycemic effects in the rat model of type 2 diabetes.Aug 01, 2008

Naringin attentuates retinoic acid-induced osteoporosis in an animal model. Jan 01, 2007

Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress.Dec 31, 2018

Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats.Aug 14, 2020

Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury.Dec 02, 2020

Naringin attenuates diabetic retinopathy by inhibiting inflammation and oxidative stress.Jun 30, 2017

Naringin can protect nucleus pulposus cells against apoptosis and ameliorate Intervertebral disc degeneration in vivo.Oct 03, 2018

Naringin combined with tunicamycin+BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells.Sep 25, 2020

Naringin could be a potential therapeutic agent to prevent the brain from ischemia-reperfusion injury.Nov 30, 2018

Naringin could be an alternative option in the management of Parkinson's disease.Jan 07, 2020

Naringin enhances reverse cholesterol transport in high fat/low streptozocin induced diabetic rats.Apr 30, 2018

Naringin exhibits Mas receptor-mediated neuroprotection against amyloid beta-induced cognitive deficits and mitochondrial toxicity.Feb 02, 2021

Naringin had a protective effect against cardiotoxicity induced by BPA.Sep 27, 2018

Naringin has a protective effect against Intracerebral hemorrhage-induced neurocognitive deficits.Dec 31, 2016

Naringin has potential antihyperglycemic activity in high-fat diet/low-dose streptozotocin-induced diabetic rats.Jun 30, 2017

Naringin improved sepsis-induced intestinal injury.Jun 30, 2018

Naringin in combination with isothiocyanates as liposomal formulations potentiates the anti-inflammatory activity.Nov 02, 2020

Naringin inhibits ovarian tumor growth by promoting apoptosis.Jun 30, 2018

Naringin is a promising therapeutic candidate for hepatic fibrosis.Oct 14, 2017

Naringin may be a promising agent for the treatment of physical fatigue.Nov 30, 2017

Naringin may be used as a potential agent to prevent gut dysbiosis and alleviate NAFLD.Dec 31, 2019

Naringin may become a new method to treat and prevent NSAIDs related intestinal diseases.Dec 14, 2020

Naringin may protect myocardium in diabetic rats by reducing mitochondrial oxidative stress injuries.Jan 31, 2018

Naringin played a protective role in cerebral infarction via suppressing neuronal apoptosis and inflammation.Jan 03, 2020

Naringin prevented colitis and colorectal carcinogenesisMar 25, 2018

Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo.Dec 31, 2016

Naringin promotes fracture healing through stimulation of angiogenesis.Jan 04, 2017

Naringin protects against Bisphenol-A induced oculopathy as implication of cataract in hypertensive rat model.Mar 11, 2020

Naringin protects against bone loss in steroid-treated inflammatory bowel disease in a rat model.Jul 14, 2018

Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity.May 14, 2018

Naringin protects against lipopolysaccharide-induced cardiac injury in mice.Nov 30, 2016

Naringin protects against perfluorooctane sulfonate-induced liver injury.Nov 30, 2018

Naringin protects against steroid‑induced avascular necrosis of the femoral head.Jan 31, 2018

Naringin protects against the liver damage caused by streptozotocin-induced diabetes.Aug 31, 2018

Naringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat model.Dec 31, 2016

Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampus.Feb 26, 2020

Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation.May 15, 2020

Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity.Nov 30, 2016

Naringin showed promising antioxidant activity which can be used as effective protecting agents against oxidative stress.Jan 03, 2021

Naringin treatment improved main clozapine-induced adverse effects.Feb 02, 2021

Naringin treatment may be useful to reduce wood smoke-induced oxidative stress and related ocular and pulmonary damage.Dec 31, 2019

Naringin treatment reduced histological alteration induced by APAP in the liver and kidney.Apr 05, 2016

Naringin was found to be an effective antidiabetic agent which increased Insulin gene expression and insulin secretion.Dec 31, 2017

Naringin was found to upregulate the FoxM1 transcription factor in diabetic animals, which influenced the proliferation and functional status of beta cells.May 07, 2019

Naringin was observed to have a protective effect on 5-FU-induced liver and kidney damage.Mar 31, 2018

Naringin's protective effect in inflammation may be beneficial for the treatment of sepsis.Dec 31, 2015

Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats.Sep 30, 2017

Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in miceDec 31, 2018

Propolis and single flavonoids, caffeic acid, chrysin and naringin are radioprotective against gamma-irradiation.Jan 01, 2008

Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model.Nov 06, 2019

Protective effect of naringin on DSS-induced ulcerative colitis in mice.Nov 25, 2018

Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion.Jun 29, 2019

Sciatic nerve regeneration by using collagen type I hydrogel containing naringin.Sep 10, 2019

The effects of chrysin and naringin on cyclophosphamide-induced erythrocyte damage.Oct 25, 2020

Citrus naringin

View the Evidence:
135 Abstracts with Citrus naringin Research