Citrus naringin

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15 Diseases Researched for Citrus naringin
NameACCKFocus
DNA damage23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Diabetes Mellitus: Type 212Locked
HIV Drug-Induced Toxicity 12Locked
Osteoporosis12Locked
Oxidative Stress12Locked
Radiation Induced Illness12Locked
Androgen-Induced Diseases11Locked
Cancers: Multi-Drug Resistant11Locked
Carcinoma: Non-Small-Cell Lung11Locked
Cervical Cancer11Locked
Chemotherapy-Induced Toxicity: Bleomycin11Locked
Gingivitis11Locked
Osteoporosis: Male11Locked
Peridontal Infection11Locked
10 Pharmacological Actions Researched for Citrus naringin
NameACCKFocus
Antioxidants12Locked
Hepatoprotective12Locked
MicroRNA modulator12Locked
Radioprotective12Locked
Renoprotective12Locked
Anti-Androgen11Locked
Anti-Bacterial Agents11Locked
Antiproliferative 11Locked
Apoptotic11Locked
Genoprotective11Locked

View the Evidence:
87 Abstracts with Citrus naringin Research

[+]

This supports the available scientific evidence on the beneficial role of naringin in the management of various neurological ailments.Sep 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:909-929. Epub 2017 Aug 16. PMID: 28810519
Article Published Date : Sep 30, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : Citrus naringin
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Naringin protects against high glucose-induced human endothelial cell injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;42(6):2540-2551. Epub 2017 Aug 23. PMID: 28848146
Article Published Date : Dec 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Citrus naringin
Diseases : Diabetes: Oxidative Stress, Diabetic Complications
Pharmacological Actions : Antioxidants
[+]

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Jun 21 ;8(1):9464. Epub 2018 Jun 21. PMID: 29930336
Article Published Date : Jun 20, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Cardiac Hypertrophy, High Fructose Diet
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Dried peel powder of C. kawachiensis had a neuroprotective effect against ischemic brain injury. Apr 03, 2018

Pubmed Data : Biosci Biotechnol Biochem. 2018 Apr 4:1-9. Epub 2018 Apr 4. PMID: 29618282
Article Published Date : Apr 03, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Citrus Peel , Fruit: All
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Cerebral Ischemia, Citrus naringin, Citrus Peel, Fruit: All, Neuroprotective Agents
[+]

Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A.Feb 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2019 Mar ;22(3):315-523. PMID: 31156794
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Bisphenol Toxicity, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Cytoprotective
Problem Substances : Bisphenol A
[+]

Naringin alleviates early brain injury after experimental subarachnoid hemorrhage.Jun 30, 2017

Pubmed Data : Brain Res Bull. 2017 Jul ;133:42-50. Epub 2016 Dec 21. PMID: 28011192
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Oxidative Stress, Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
[+]

Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.Jul 10, 2019

Pubmed Data : Connect Tissue Res. 2019 Jul 11:1-14. Epub 2019 Jul 11. PMID: 31294637
Article Published Date : Jul 10, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Apoptotic
Additional Keywords : Mesenchymal Stem Cells
[+]

Naringin also regulates endothelial cell function and promotes angiogenesis to exert its anti‑osteoporotic effect.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Dec ;40(6):1741-1749. Epub 2017 Sep 28. PMID: 29039439
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Apoptotic
[+]

Naringin ameliorated oxidative stress and nucleoside reverse transcriptase inhibitors-induced mitochondrial damage.Dec 31, 2015

Pubmed Data : Curr HIV Res. 2016 ;14(6):506-516. PMID: 27197616
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Vitamin E
Diseases : HIV Drug-Induced Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Antioxidants, Citrus naringin, HIV Drug-Induced Toxicity, oxidative stress, reactive oxygen species (ROS), VITAMIN E
[+]

Naringin ameliorates endothelial dysfunction in fructose-fed rats.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Mar ;15(3):3140-3146. Epub 2018 Jan 17. PMID: 29456717
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Endothelial Dysfunction
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Naringin and vitamin C demonstrates antihyperglycemic effects in the rat model of type 2 diabetes.Aug 01, 2008

Pubmed Data : J Appl Toxicol. 2008 Aug;28(6):806-13. PMID: 18344197
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetes Mellitus: Type 2
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Naringin attentuates retinoic acid-induced osteoporosis in an animal model. Jan 01, 2007

Pubmed Data : Am J Chin Med. 2007;35(4):663-7. PMID: 17708632
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Osteoporosis
[+]

Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress.Dec 31, 2018

Pubmed Data : Life Sci. 2019 Jan 1 ;216:305-312. Epub 2018 Jul 18. PMID: 30031061
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective
[+]

Naringin attenuates diabetic retinopathy by inhibiting inflammation and oxidative stress.Jun 30, 2017

Pubmed Data : Iran J Basic Med Sci. 2017 Jul ;20(7):813-821. PMID: 28852447
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Naringin can protect nucleus pulposus cells against apoptosis and ameliorate Intervertebral disc degeneration in vivo.Oct 03, 2018

Pubmed Data : Am J Chin Med. 2018 Oct 4:1-20. Epub 2018 Oct 4. PMID: 30284462
Article Published Date : Oct 03, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Intervertebral Disk Displacement
Pharmacological Actions : Anti-Apoptotic
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Naringin could be a potential therapeutic agent to prevent the brain from ischemia-reperfusion injury.Nov 30, 2018

Pubmed Data : Mol Neurobiol. 2018 Dec ;55(12):9029-9042. Epub 2018 Apr 7. PMID: 29627876
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Blood Brain Barrier
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Naringin could be an alternative option in the management of Parkinson's disease.Jan 07, 2020

Pubmed Data : Neuromolecular Med. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31916219
Article Published Date : Jan 07, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
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Naringin enhances reverse cholesterol transport in high fat/low streptozocin induced diabetic rats.Apr 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 May ;101:430-437. Epub 2018 Mar 22. PMID: 29501765
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetes Mellitus: Type 2, Diabetic Complications
Pharmacological Actions : Anti-atherogenic
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Naringin had a protective effect against cardiotoxicity induced by BPA.Sep 27, 2018

Pubmed Data : Drug Chem Toxicol. 2018 Sep 28:1-11. Epub 2018 Sep 28. PMID: 30264589
Article Published Date : Sep 27, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Bisphenol Toxicity
Pharmacological Actions : Antioxidants, Cardioprotective, Hypolipidemic
Problem Substances : Bisphenol A
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Naringin has a protective effect against Intracerebral hemorrhage-induced neurocognitive deficits.Dec 31, 2016

Pubmed Data : Pharmacology. 2017 ;100(3-4):172-187. Epub 2017 Jul 1. PMID: 28668949
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Cerebral Hemorrhage, Hyperalgesia, Lipid Peroxidation
Pharmacological Actions : Neuroprotective Agents, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Naringin has potential antihyperglycemic activity in high-fat diet/low-dose streptozotocin-induced diabetic rats.Jun 30, 2017

Pubmed Data : Gen Physiol Biophys. 2017 Jul ;36(3):343-352. PMID: 28635611
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetic Complications, High Fat Diet
Pharmacological Actions : Hypoglycemic Agents
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Naringin improved sepsis-induced intestinal injury.Jun 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:50-58. Epub 2018 Apr 7. PMID: 29635128
Article Published Date : Jun 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-10 upregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Naringin inhibits ovarian tumor growth by promoting apoptosis.Jun 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Jul ;16(1):59-64. Epub 2018 May 2. PMID: 29928387
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
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Naringin is a promising therapeutic candidate for hepatic fibrosis.Oct 14, 2017

Pubmed Data : Life Sci. 2017 Oct 15 ;187:50-57. Epub 2017 Aug 19. PMID: 28830755
Article Published Date : Oct 14, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation
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Naringin may be a promising agent for the treatment of physical fatigue.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2017 Dec ;55(1):423-427. PMID: 27937032
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Fatigue
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor
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Naringin may protect myocardium in diabetic rats by reducing mitochondrial oxidative stress injuries.Jan 31, 2018

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Feb ;43(3):596-602. PMID: 29600628
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Cardiomyopathy, Diabetes: Oxidative Stress, Diabetic Complications
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Cardioprotective
[+]

Naringin played a protective role in cerebral infarction via suppressing neuronal apoptosis and inflammation.Jan 03, 2020

Pubmed Data : Med Sci Monit. 2020 Jan 4 ;26:e918772. Epub 2020 Jan 4. PMID: 31901198
Article Published Date : Jan 03, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Stroke
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Naringin prevented colitis and colorectal carcinogenesisMar 25, 2018

Pubmed Data : Cancer Biol Ther. 2018 Mar 26:1-10. Epub 2018 Mar 26. PMID: 29580144
Article Published Date : Mar 25, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents
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Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(11):e0183355. Epub 2017 Nov 9. PMID: 29121676
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : HIV Drug-Induced Toxicity
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Naringin promotes fracture healing through stimulation of angiogenesis.Jan 04, 2017

Pubmed Data : Chem Biol Interact. 2017 Jan 5 ;261:11-17. Epub 2016 Nov 8. PMID: 27833010
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Bone Fractures, Osteoporosis
Pharmacological Actions : Angiogenesis Inducing Agents
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Naringin protects against bone loss in steroid-treated inflammatory bowel disease in a rat model.Jul 14, 2018

Pubmed Data : Arch Biochem Biophys. 2018 Jul 15 ;650:22-29. Epub 2018 May 17. PMID: 29753722
Article Published Date : Jul 14, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : MicroRNA modulator, Osteoprotective
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Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity.May 14, 2018

Pubmed Data : Environ Sci Pollut Res Int. 2018 May 15. Epub 2018 May 15. PMID: 29766429
Article Published Date : May 14, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Renoprotective
[+]

Naringin protects against lipopolysaccharide-induced cardiac injury in mice.Nov 30, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Dec ;48:1-6. Epub 2016 Sep 13. PMID: 27716530
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Naringin protects against perfluorooctane sulfonate-induced liver injury.Nov 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Dec ;65:140-147. Epub 2018 Oct 10. PMID: 30316072
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemically-Induced Liver Damage, Perfluorooctane Sulfonate-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Perfluorooctane sulfonate (PFOS)
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Naringin protects against steroid‑induced avascular necrosis of the femoral head.Jan 31, 2018

Pubmed Data : Mol Med Rep. 2018 Feb ;17(2):3328-3335. Epub 2017 Dec 11. PMID: 29257271
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Steroid-Induced Toxicity
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Naringin protects against the liver damage caused by streptozotocin-induced diabetes.Aug 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Sep ;105:95-102. Epub 2018 May 28. PMID: 29852394
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetes Mellitus: Type 1: Prevention, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-6 Downregulation
[+]

Naringin protects viscera from ischemia/reperfusion injury by regulating the nitric oxide level in a rat model.Dec 31, 2016

Pubmed Data : Biotech Histochem. 2017 ;92(4):252-263. Epub 2017 Apr 20. PMID: 28426254
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Ischemia
Pharmacological Actions : Nitric Oxide Inhibitor
[+]

Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity.Nov 30, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1717-1726. Epub 2016 Nov 9. PMID: 27836465
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Aluminum Toxicity , Lipid Peroxidation, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aluminum Chloride
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Naringin treatment reduced histological alteration induced by APAP in the liver and kidney.Apr 05, 2016

Pubmed Data : Ren Fail. 2016 Apr 6:1-14. Epub 2016 Apr 6. PMID: 27050864
Article Published Date : Apr 05, 2016
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Hepatoprotective, MicroRNA modulator, Renoprotective
Problem Substances : Paracetamol
[+]

Naringin was found to be an effective antidiabetic agent which increased Insulin gene expression and insulin secretion.Dec 31, 2017

Pubmed Data : Cells Tissues Organs. 2018 ;206(3):133-143. Epub 2019 Mar 18. PMID: 30884485
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Insulin Resistance
Pharmacological Actions : Insulin-releasing
Additional Keywords : Gene Expression Regulation
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Naringin was found to upregulate the FoxM1 transcription factor in diabetic animals, which influenced the proliferation and functional status of beta cells.May 07, 2019

Pubmed Data : Cells Tissues Organs. 2019 May 8:1-12. Epub 2019 May 8. PMID: 31067533
Article Published Date : May 07, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : MicroRNA modulator, Pancreato Protective Agents
[+]

Naringin was observed to have a protective effect on 5-FU-induced liver and kidney damage.Mar 31, 2018

Pubmed Data : Iran J Basic Med Sci. 2018 Apr ;21(4):404-410. PMID: 29796225
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective, Renoprotective
[+]

Naringin's protective effect in inflammation may be beneficial for the treatment of sepsis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(10):e0164186. Epub 2016 Oct 7. PMID: 27716835
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats.Sep 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:197-205. Epub 2017 Jul 28. PMID: 28759757
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Citrus Peel , Naringenin
Diseases : Alcohol Toxicity , Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
Additional Keywords : Plant Extracts
[+]

Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in miceDec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:536-546. Epub 2018 Nov 3. PMID: 30399589
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Anxiety, Depression, Memory Disorders
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Propolis and single flavonoids, caffeic acid, chrysin and naringin are radioprotective against gamma-irradiation.Jan 01, 2008

Pubmed Data : Biol Pharm Bull. 2008 Jan;31(1):167-72. PMID: 18175964
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Caffeic Acid, Chrysin, Citrus naringin
Diseases : DNA damage, Radiation Induced Illness
Pharmacological Actions : Radioprotective
[+]

Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model.Nov 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Nov 7 ;121:109594. Epub 2019 Nov 7. PMID: 31707344
Article Published Date : Nov 06, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Citrus Peel , Orange
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Cancer Stem Cells
[+]

Protective effect of naringin on DSS-induced ulcerative colitis in mice.Nov 25, 2018

Pubmed Data : J Agric Food Chem. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30472831
Article Published Date : Nov 25, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion.Jun 29, 2019

Pubmed Data : Phytomedicine. 2019 Jun 30 ;63:153004. Epub 2019 Jun 30. PMID: 31301536
Article Published Date : Jun 29, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Air Pollution Linked Toxicity, Diesel Exhaust Particle Toxicity
Pharmacological Actions : Cytoprotective
[+]

Sciatic nerve regeneration by using collagen type I hydrogel containing naringin.Sep 10, 2019

Pubmed Data : J Mater Sci Mater Med. 2019 Sep 11 ;30(9):107. Epub 2019 Sep 11. PMID: 31512084
Article Published Date : Sep 10, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Peripheral Nerve Diseases, Sciatica
Additional Keywords : Nerve Regeneration
[+]

The effects of naringin on different cyclophosphamide-induced organ toxicities.Jul 09, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Jul 10. Epub 2019 Jul 10. PMID: 31292874
Article Published Date : Jul 09, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
Problem Substances : Cyclophosphamide
[+]

The navel orange peel hydroethanolic extract, naringin, and naringenin induced potential hepatopreventive effects.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:2745352. Epub 2019 Mar 26. PMID: 31049130
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Citrus Peel , Naringenin , Orange
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Hepatoprotective
[+]

The renoprotective effects of naringin on renal ischemia/reperfusion injury.Feb 15, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb 16 ;112:108568. Epub 2019 Feb 16. PMID: 30780111
Article Published Date : Feb 15, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, MicroRNA modulator, Renoprotective
[+]

These findings suggest that naringin possesses anti-depressant- and anxiolytic-like activities as well as memory enhancing effect in mice.Jul 31, 2018

Pubmed Data : Drug Res (Stuttg). 2018 Aug ;68(8):465-474. Epub 2018 Mar 12. PMID: 29529676
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents
[+]

This data indicate a potentially effective therapeutic approach of naringin and naringenin for cough variant asthma.Aug 31, 2019

Pubmed Data : J Med Food. 2019 Sep ;22(9):963-970. Epub 2019 Jun 28. PMID: 31259654
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Naringenin
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
[+]

This study demonstrated that naringin ameliorates diabetic nephropathy.Jun 04, 2017

Pubmed Data : Eur J Pharmacol. 2017 Jun 5 ;804:1-6. Epub 2017 Apr 7. PMID: 28395989
Article Published Date : Jun 04, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Apoptotic, Enzyme Inhibitors, Renoprotective
[+]

Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats.Sep 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:1028-1037. Epub 2017 Aug 12. PMID: 28813782
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Hyperammonemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats.Jun 01, 2009

Pubmed Data : Phytomedicine. 2009 Jun;16(6-7):513-20. Epub 2008 Oct 18. PMID: 18930642
Article Published Date : Jun 01, 2009
Study Type : Commentary
Additional Links
Substances : Citrus naringin, Citrus Peel
Diseases : Osteoporosis: Male
[+]

Induction of human hepatocellular carcinoma HepG2 cell apoptosis by naringin.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2016 ;17(7):3289-94. PMID: 27509965
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Naringenin increases the chemosensitization of cancer cells. Jan 01, 2009

Pubmed Data : Z Naturforsch C. 2009 Jan-Feb;64(1-2):109-16. PMID: 19323275
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Cancers: Multi-Drug Resistant
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Naringenin, and related compounds, have anti-androgenic properties. Sep 01, 2003

Pubmed Data : Planta Med. 2003 Sep;69(9):856-8. PMID: 14598215
Article Published Date : Sep 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin, Naringenin
Diseases : Androgen-Induced Diseases
Pharmacological Actions : Anti-Androgen
[+]

Naringin abates adverse effects of cadmium-mediated hepatotoxicity.Jul 31, 2017

Pubmed Data : J Biochem Mol Toxicol. 2017 Aug ;31(8). Epub 2017 Apr 19. PMID: 28422390
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Cadmium Poisoning , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Nrf2 activation
Problem Substances : Cadmium
[+]

Naringin acts as a chemosensitizer which synergistically strengthens the cytotoxic effect of paclitaxel in prostate cancer cells.Nov 30, 2018

Pubmed Data : Prostate Int. 2018 Dec ;6(4):126-135. Epub 2017 Nov 28. PMID: 30505814
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Prostate Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Naringin ameliorates the high glucose-induced rat mesangial cell inflammatory.Jun 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jun 22 ;18(1):192. Epub 2018 Jun 22. PMID: 29929501
Article Published Date : Jun 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Naringin and naringenin could serve as anti-inflammatory agents in the treatment of low back pain and sciatica.Oct 03, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Spine J. 2019 Oct 4. Epub 2019 Oct 4. PMID: 31575107
Article Published Date : Oct 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin, Naringenin
Diseases : Low Back Pain, Sciatica
Pharmacological Actions : Anti-Inflammatory Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Naringin can upregulate the expression of miR-19b mRNA and induce HepG2 cell apoptosis.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Aug ;14(2):1455-1459. Epub 2017 May 29. PMID: 28789364
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
[+]

Naringin dose dependently decreased the total chromosome aberrations frequency induced by bleomycin.May 04, 2015

Pubmed Data : Drug Chem Toxicol. 2015 May 5:1-5. Epub 2015 May 5. PMID: 25941869
Article Published Date : May 04, 2015
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, DNA damage
Pharmacological Actions : Genoprotective
Additional Keywords : Dose Response
[+]

Naringin effectively ameliorates gut-vascular barrier disruption.Dec 17, 2019

Pubmed Data : J Agric Food Chem. 2019 Dec 18. Epub 2019 Dec 18. PMID: 31850758
Article Published Date : Dec 17, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Gastrointestinal Diseases, Gastrointestinal Inflammation
Pharmacological Actions : Gastroprotective
[+]

Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2017 Apr ;20(4):408-414. PMID: 28804610
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Mesenchymal Stem Cells
[+]

Naringin inhibits lipopolysaccharide-induced activation of microglia cells.Jun 29, 2019

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jun 30 ;65(5):38-42. Epub 2019 Jun 30. PMID: 31304904
Article Published Date : Jun 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Naringin inhibits thyroid cancer cell proliferation and induces cell apoptosis through repressing PI3K/AKT pathway.Nov 30, 2019

Pubmed Data : Pathol Res Pract. 2019 Dec ;215(12):152707. Epub 2019 Oct 23. PMID: 31727500
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Thyroid Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Naringin is an antioxidant that appears to be efficacious in alleviating metabolic syndrome.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:9752826. Epub 2019 Feb 3. PMID: 30854019
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Citrus naringin
Diseases : Metabolic Syndrome X
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic
[+]

naringin is an effective compound for promoting bone repair and preventing bone loss.Apr 30, 2019

Pubmed Data : Chem Biol Interact. 2019 May 1 ;304:97-105. Epub 2019 Mar 14. PMID: 30878453
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Osteonecrosis
Pharmacological Actions : Anti-Apoptotic, Osteoprotective
[+]

Naringin may possess novel therapeutic potential for protection against LPS-induced myocardial dysfunction.Jul 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul 31 ;75:105782. Epub 2019 Jul 31. PMID: 31376623
Article Published Date : Jul 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Naringin possesses significant antimicrobial properties on peridontal pathogens.Mar 01, 2008

Pubmed Data : Phytother Res. 2008 Mar;22(3):401-6. PMID: 18167053
Article Published Date : Mar 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Gingivitis, Peridontal Infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Naringin prevents UVB-mediated inflammation and oxidative damage in NIH-3T3 cells.Dec 03, 2018

Pubmed Data : J Biochem Mol Toxicol. 2018 Dec 4:e22263. Epub 2018 Dec 4. PMID: 30512238
Article Published Date : Dec 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Photoprotective
[+]

Naringin protects against HIV-1 protease inhibitors-induced pancreatic β-cell dysfunction and apoptosis.Jan 04, 2016

Pubmed Data : Mol Cell Endocrinol. 2016 12 5 ;437:1-10. Epub 2016 Aug 2. PMID: 27496642
Article Published Date : Jan 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : HIV Drug-Induced Toxicity , Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Pancreato Protective Agents
[+]

Naringin protects pancreatic β-cells against oxidative stress-induced apoptosis. Feb 28, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Mar ;62(5). Epub 2018 Feb 5. PMID: 29314619
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Diabetes: Oxidative Stress, Diabetic Complications
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Pancreato Protective Agents
[+]

Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway.Apr 30, 2016

Pubmed Data : J Dermatol Sci. 2016 May ;82(2):106-14. Epub 2015 Dec 22. PMID: 26908354
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Inflammation, Ultraviolet Radiation Induced Damage
Therapeutic Actions : Sunlight exposure
Pharmacological Actions : Anti-Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Naringin suppresses the growth and motility of hypertrophic scar fibroblasts.Aug 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Sep ;105:1291-1298. Epub 2018 Jun 23. PMID: 30021366
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Scars, Wound Healing
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis.Dec 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2018 Dec 22 ;10(12):4141-4151. PMID: 30580326
Article Published Date : Dec 21, 2018
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Antiproliferative
[+]

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes.Nov 30, 2017

Pubmed Data : J Biochem Mol Toxicol. 2017 Dec ;31(12). Epub 2017 Sep 13. PMID: 28902458
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Chrysin, Citrus naringin, Ginger, Hesperidin, Polyphenols
Diseases : Hypoglycemia
Pharmacological Actions : Acetylcholinesterase Inhibitor, Alpha-glucosidase inhibitor , Hypoglycemic Agents
[+]

The mechanism of Naringin-enhanced remyelination after spinal cord injury.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2017 Mar ;12(3):470-477. PMID: 28469664
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Spinal Cord Injuries
Additional Keywords : Nerve Regeneration
[+]

Therapeutic potential of naringin in neurological disorders.Jun 25, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jun 26 ;132:110646. Epub 2019 Jun 26. PMID: 31252025
Article Published Date : Jun 25, 2019
Study Type : Review
Additional Links
Substances : Citrus naringin
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

These results suggest a novel mechanism of naringin in the suppression of cancer cell growth through the alteration of glycolipids.Apr 18, 2016

Pubmed Data : Eur J Pharmacol. 2016 Apr 19. Epub 2016 Apr 19. PMID: 27105818
Article Published Date : Apr 18, 2016
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Carcinoma: Non-Small-Cell Lung, Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

These results suggest that naringin can be utilized as a potential treatment of neurodegenerative disorders.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2017 Apr ;39(4):819-830. Epub 2017 Feb 22. PMID: 28260042
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Citrus naringin
Diseases : Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Nrf2 activation
[+]

This review shows the enhancing effects of bioenhancers of drugs, nutrients and vitamins in animals and humans.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2012 ;2012:637953. Epub 2012 Sep 17. PMID: 23028251
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Substances : Allicin, Aloe Vera, Capsaicin, Citrus naringin, Curcumin, Genistein, Glycyrrhizin, Piperine, Quercetin
Additional Keywords : Drug Interaction, Natural Substance/Drug Synergy, Supplementation

Copyright: lightwise / 123RF Stock Photo

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Researchers from China's State Agriculture Ministry and Zhejiang University have determined that two ingredients commonly found in many citrus fruits, naringin and neohesperidin, will effectively reduce blood sugar

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