Flavonoids

Name	AC	CK
Hypertension	15	128
Cardiovascular Diseases	17	108
Oxidative Stress	49	93
Inflammation	33	84
Colorectal Cancer	12	83
Endothelial Dysfunction	14	79
Cholesterol: Oxidation	13	61
HDL: Low	4	40
Radiation Induced Illness	12	38
Arteriosclerosis	6	34
Breast Cancer	19	33
Diabetes Mellitus: Type 2: Prevention	4	33
Coronary Artery Disease	5	32
Diabetes Mellitus: Type 2	9	31
Thrombosis	4	31
All-Cause Mortality	2	30
Cardiovascular Disease: Prevention	3	30
Hemorrhoids	3	30
Obesity	7	29
Depression	7	28
Lipopolysaccharide-Induced Toxicity	14	28
DNA damage	12	26
Cognitive Decline/Dysfunction	4	24
Clotting	4	23
Aging	8	22
C-Reactive Protein	3	22
Cancers: All	21	22
Cholesterol: LDL/HDL ratio	3	22
Colon Cancer	18	22
Glaucoma	2	22
Alzheimer's Disease	15	21
Esophageal Cancer	3	21
Allergic Rhinitis	2	20
Cancer Mortality	1	20
Cardiac Mortality	1	20
Chronic Disease	2	20
Deep Vein Thrombosis	2	20
Diabetes: Cardiovascular Illness	2	20
Ocular Hypertension	1	20
Parkinson's Disease	9	20
Prehypertension	1	20
Rectal Cancer	1	20
Smoking	2	20
Liver Cancer	8	18
Colorectal Cancer: Prevention	3	17
Aging: Brain	4	16
Prostate Cancer	13	16
Insulin Resistance	4	15
Lipid Peroxidation	10	15
Metabolic Syndrome X	3	14
Ovarian Cancer	4	14
Chemically-Induced Liver Damage	7	13
Heart Failure	3	13
Lung Cancer	11	13
Myocardial Infarction	3	13
Pesticide Toxicity	3	13
Rheumatoid Arthritis	3	13
Sunburn	3	13
Aging Skin	3	12
Arsenic Poisoning	2	12
Helicobacter Pylori Infection	3	12
Hyperuricemia	2	12
Menopausal Syndrome	2	12
Gout	2	11
High Cholesterol	2	11
Neurodegenerative Diseases	8	11
Skin Diseases: Photo-Aging	2	11
Stroke	2	11
Aflatoxicosis	1	10
Aphthous Ulcer	1	10
Asthma	1	10
Athletic Performance	1	10
Athletic Performance: Recovery	1	10
Bile Duct Cancer	1	10
Bladder Degeneration	1	10
Blood Platelet Disorders	1	10
Bone Fractures	1	10
Brain Edema	1	10
Chemotherapy	1	10
Chronic Obstructive Pulmonary Disease	1	10
Climacteric	1	10
Common Cold	1	10
Dental Caries	1	10
Depression	1	10
Dystrophic retinal detachment (DRD)	1	10
Edema	1	10
Erectile Dysfunction	1	10
Eye Diseases: Vitreous Disorders	1	10
Gallbladder Cancer	1	10
Head and Neck Cancer	1	10
Heart Disease: Ischemic	1	10
Hematuria	1	10
Jet Lag	1	10
Leg Edema	1	10
Libido: Low	1	10
Macular Degeneration	1	10
Osteoarthritis: Knee	1	10
Peripheral vitreochoreoretinal dystrophies (PVCRD)	1	10
Post-Thrombotic Syndrome	1	10
Postmenopausal Disorders: Insomnia	1	10
Postoperative Recovery	1	10
Premenstrual syndrome	1	10
Pulmonary Diseases	1	10
Retinal Detachment	1	10
Sexaul Dysfunction	1	10
Thromboembolism	1	10
Tinnitus	1	10
Venous Thrombosis	1	10
Vericose Veins: Bladder	1	10
Wrinkles	1	10
Hyperlipidemia	5	9
Pancreatic Cancer	5	9
Brain Inflammation	6	8
Cancers: Drug Resistant	7	8
Hyperglycemia	7	8
Cancer Metastasis	4	7
Gastric Ulcer	4	7
Hypercholesterolemia	4	7
Liver Cancer: Prevention	2	7
Breast Cancer: Metastatic	3	6
Cervical Cancer	6	6
Diabetes Mellitus: Type 1	4	6
Myocardial Ischemia	3	6
Breast Cancer: Triple Negative	3	5
Cancers: Multi-Drug Resistant	5	5
Carcinoma: Non-Small-Cell Lung	5	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Diabetic Complications	3	5
Melanoma	4	5
Memory Disorders	3	5
Oral Cancer	3	5
Tumors	4	5
Advanced Glycation End products (AGE)	3	4
Aging: Immunosenecence	2	4
Alcohol Toxicity	2	4
Alcoholic Liver Disease	2	4
Anxiety	2	4
Atherosclerosis	3	4
Cerebral Ischemia	2	4
HIV Infections	4	4
High Fat Diet	2	4
Immune Disorders: Low Immune Function	2	4
Inflammatory Bowel Diseases	2	4
Neuroblastoma	2	4
Seizures	2	4
Ultraviolet Radiation Induced Damage	4	4
Allergies	2	3
Brain Injury: Traumatic	2	3
Brain Ischemia	3	3
Cholera	2	3
Dementia	3	3
Diabetes: Cataract	2	3
Dioxin Toxicity	2	3
Dyslipidemias	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoxia	2	3
Liver Damage	2	3
MRSA	2	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoporosis	2	3
Snake Bite: Venom Toxicity	2	3
Abdominal Obesity (Midsection Fat)	1	2
Aluminum Toxicity	1	2
Anaphylaxis	1	2
Arthritis	1	2
Aspirin-Induced Toxicity	1	2
Autism	1	2
Bladder Cancer	2	2
Bone Diseases	1	2
Brain Injury: Hippocampal Damage	1	2
Brain: Microglial Activation	2	2
Breast Cancer: Lung Metastasis	1	2
Candida Albicans	2	2
Cardiomyopathy	1	2
Cataract	1	2
Cerebral Vasospasm	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chikungunya Virus	2	2
Colon Polyps	1	2
Convulsions	1	2
Cystic Fibrosis	2	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Nephropathy	1	2
Diesel Exhaust Particle Toxicity	1	2
Dopamine Deficiency	1	2
Estrogen Dominance	2	2
Fatty Liver	1	2
Food Allergies	1	2
Fructose-Induced Toxicity	1	2
Giardiasis	2	2
Heat Stroke	1	2
High Fructose Diet	1	2
Hypothyroidism	1	2
IgA Deficiency	1	2
IgE-Mediated Hypersensitivity	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Infertility: Male	1	2
Intestinal Diseases	1	2
Intestinal Permeability	2	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Leaky Gut Syndrome	2	2
Learning disorders	1	2
Leukemia	2	2
Leukemia: Acute myelogenous leukemia (AML)	1	2
Leukemia: Chronic myelogenous leukemia (CML)	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Immune Function: Thymus Dysfunction	1	2
Lymphoma	1	2
Mercury Poisoning	1	2
Mouse Endogenous Retroviruses	1	2
NSAID-induced toxicity	1	2
Osteoarthritis	1	2
Ovariectomy Associated Adverse Changes	1	2
Periodontitis	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Petroleum Exposure And Toxicity	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Promyelocytic leukemia	2	2
Prostatic Hyperplasia: Benign	1	2
Radiation Induced Illness: Bone Marrow	1	2
Scars	1	2
Skin Cancer	1	2
Skin Cancer: Prevention	1	2
Sperm Quality: Low	1	2
Squamous cell carcinoma	1	2
Staphylococcus aureus infection	2	2
Systemic Lupus Erythematosus	1	2
Thyroid Cancer	2	2
Wound Healing	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Amyloidosis	1	1
Amyotrophic Lateral Sclerosis	1	1
Anemia: Hemolytic	1	1
Aspergillosis	1	1
Bacillus subtilis infections	1	1
Bacterial Infections	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain: Oxidative Stress	1	1
Cancers	1	1
Candida Infection	1	1
Chemotherapy and Radiation Toxicity	1	1
Cholangiocarcinoma	1	1
Chronic Myeloid Leukemia	1	1
Clostridium Infections	1	1
Colitis	1	1
Copper Toxicity	1	1
Cryptosporidiosis	1	1
Cytomegalovirus Infections	1	1
Epstein-Barr Virus Infections	1	1
Escherichia coli Infections	1	1
Excitotoxicity	1	1
Fatigue	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Glucosephosphate Dehydrogenase Deficiency	1	1
HSV-1	1	1
HSV-2	1	1
High Homocysteine	1	1
Hyperinsulinism	1	1
Hypertension: Pulmonary	1	1
Influenza in Swine	1	1
Kidney Damage: Drug-Induced	1	1
Klebsiella Infections	1	1
Leishmaniasis	1	1
Liver Disease	1	1
Malaria	1	1
Malignant Melanoma	1	1
Micrococcus luteus infections	1	1
Mycobacterium tuberculosis	1	1
Neurological Conditions	1	1
Non-Small-Cell Lung Carcinoma	1	1
Osteosarcoma	1	1
Protozoan Infections	1	1
Pseudomonas aeruginosa	1	1
Psychiatric Disorders	1	1
Radiation	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Rhinovirus Infection	1	1
Schizophrenia	1	1
Simian virus 40 (SV40)	1	1
Staphylococcus epidermidis	1	1
Sugar (Sucrose) Toxicity	1	1
Swine Flu Associated Virus	1	1
Tertiary butyl hydroperoxide toxicity	1	1
Testicular Cancer	1	1
Triglycerides: Elevated	1	1
Vibrio Infections	1	1
Weight Problems	1	1

Name	AC	CK
Antioxidants	147	310
Chemopreventive	37	116
Anti-Inflammatory Agents	51	94
Antiproliferative	64	81
Apoptotic	66	79
Neuroprotective Agents	36	68
Platelet Aggregation Inhibitors	7	62
NF-kappaB Inhibitor	22	46
Tumor Necrosis Factor (TNF) Alpha Inhibitor	22	46
Anticarcinogenic Agents	22	40
Hypotensive	2	40
Cell cycle arrest	27	39
Hypoglycemic Agents	15	39
Cyclooxygenase 2 Inhibitors	21	38
Cardioprotective	11	36
Interleukin-1 beta downregulation	15	34
Antineoplastic Agents	21	33
Anti-Apoptotic	15	32
Radioprotective	12	29
Antidepressive Agents	6	27
Hepatoprotective	14	26
Interleukin-6 Downregulation	15	26
Analgesics	4	24
Antihypertensive Agents	5	24
Vasodilator Agents	4	23
Enzyme Inhibitors	17	21
Anti-metastatic	11	19
Anticholesteremic Agents	4	15
Chemotherapeutic	12	13
MicroRNA modulator	3	13
Anti-Allergic Agents	2	12
Anti-Platelet	2	11
Nitric Oxide Enhancer	2	11
Anti Inflammatory	2	10
Anti-Bacterial Agents	9	10
Anti-thrombotic	1	10
Calcium Channel Blockers	1	10
Cardiovascular Agents	1	10
Detoxifier	1	10
Hypolipidemic	7	10
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	10
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	10
Chemosensitizer	8	9
Immunomodulatory	5	9
Tumor Suppressor Protein p53 Upregulation	8	9
Anti-Ulcer Agents	4	8
Antiviral Agents	7	7
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	7
Alpha-glucosidase inhibitor	4	5
Anti-Angiogenic	4	5
Antifungal Agents	5	5
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	5
Interleukin-10 downregulation	3	5
Nitric Oxide Inhibitor	3	5
Nrf2 activation	3	5
Photoprotective	4	5
Renoprotective	3	5
Anti-Anxiety Agents	2	4
Anticonvulsants	2	4
Antimutagenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Chemoprotective Agents	2	4
Genoprotective	3	4
Malondialdehyde Down-regulation	2	4
Phase II Detoxification Enzyme Inducer	2	4
Anti-HIV Agents	3	3
Antimicrobial	2	3
Cyclooxygenase 1 Inhibitor	2	3
Cytoprotective	2	3
5-Lipoxygenase Inhibitor	2	2
Aldose reductase inhibitor	1	2
Alpha-amylase inhibitor	2	2
Anti-Tumor	1	2
Antidiarrheals	1	2
Antinoceceptive	1	2
Caspase-3 Activation	2	2
Cyclooxygenase Inhibitors	1	2
Cytotoxic	2	2
Dopaminergic	1	2
Gastroprotective	2	2
Heme oxygenase-1 up-regulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-4 downregulation	2	2
Iron Chelating Agents	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Proteasome Inhibitors	2	2
Superoxide Dismutase Up-regulation	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-Estrogenic	1	1
Antiprotozoal Agents	1	1
Aromatase Inhibitors	1	1
Cytotoxicity	1	1
DNA Repair Up-regulation	1	1
E-cadherin down-regulation	1	1
Estrogen Receptor Agonist	1	1
Expectorants	1	1
Forkhead Transcription Factor Family O (FOXO) Modulator	1	1
Gastrointestinal Agents	1	1
Glucagon Like Peptide 1 (GLP-1) Down-Regulation	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Gluconeogenesis Inhibitor	1	1
Glutathione Upregulation	1	1
Histamine Antagonists	1	1
Histone deacetylase inhibitor	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Immunostimulatory	1	1
Insulin-releasing	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Leukotriene Antagonists	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Metal Chelation: Copper	1	1
Neurominidase Inhibitor	1	1
Osteoprotective	1	1
P-glycoprotein Inhibitors	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Postaglandin PGE2 downregulation	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Sedative effects	1	1
Telomere Protective	1	1
Topoisomerase II Inhibitor	1	1
Vasoprotective	1	1
Wnt/β-catenin signaling pathway modulation	1	1
Xanthine oxidase inhibitor	1	1
interleukin-13 down-regulation	1	1

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Jul 23 ;10(7). Epub 2018 Jul 23. PMID: 30041489

Article Published Date : Jul 22, 2018

Study Type : Meta Analysis

Additional Links

Substances : Apigenin, Flavonoids, Quercetin

Diseases : Colorectal Cancer, Rectal Cancer

Pharmacological Actions : Chemopreventive

[+]

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : Medicine (Baltimore). 2018 May ;97(19):e0686. PMID: 29742713

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Pubmed Data : Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Sep;35(5):383-4. PMID: 11780252

Article Published Date : Sep 01, 2000

Study Type : Human Study

Additional Links

Substances : Flavonoids, Green Tea, Polyphenols

Diseases : Dental Caries

[+]

A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2008 Apr 14;14(14):2187-93. PMID: 18407592

Article Published Date : Apr 14, 2008

Study Type : Human Study

Additional Links

Substances : Apigenin, Catechin , Flavonoids

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

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Pubmed Data : Clin Ther. 2005 Jun;27(6):746-54. PMID: 16117981

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Substances : Diosmin , Flavonoids, Hesperidin

Diseases : Hemorrhoids

[+]

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

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Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

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Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9033-8. Epub 2009 May 18. PMID: 17344491

Click here to read the entire abstract

Pubmed Data : Nutr Res. 2018 Jul ;55:65-71. Epub 2018 Apr 21. PMID: 29914629

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2007 Jun;21(6):501-6. PMID: 19444905

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Clin Nutr. 2016 09 ;104(3):704-14. Epub 2016 Jul 13. PMID: 27413131

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Flavonoids

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Risk Reduction

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Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture related hospitalizations in elderly women at high risk of fracture.Aug 11, 2015

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Pubmed Data : Am J Clin Nutr. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26269364

Article Published Date : Aug 11, 2015

Study Type : Human Study

Additional Links

Substances : Black Tea, Flavonoids

Diseases : Bone Fractures

Additional Keywords : Risk Reduction

[+]

Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.Jun 30, 2012

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Pubmed Data : Ann Neurol. 2012 Jul ;72(1):135-43. Epub 2012 Apr 26. PMID: 22535616

Article Published Date : Jun 30, 2012

Study Type : Human Study

Additional Links

Substances : Berries: All, Blueberry, Flavonoids, Strawberry

Diseases : Aging, Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2008 Feb ;29(2):411-7. Epub 2008 Jan 12. PMID: 18192689

Article Published Date : Jan 31, 2008

Click here to read the entire abstract

Pubmed Data : Clin Appl Thromb Hemost. 2005 Jul ;11(3):289-94. PMID: 16015414

Click here to read the entire abstract

Pubmed Data : Life Sci. 2004 Oct 8;75(21):2505-13. PMID: 15363656

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Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

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Pubmed Data : J Microbiol Biotechnol. 2017 Jul 28 ;27(7):1257-1265. PMID: 28535611

Article Published Date : Jul 27, 2017

Study Type : Human Study

Additional Links

Substances : Flavonoids, Kaempferol, Quercetin, Sea buckthorn

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.Jul 10, 2001

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Pubmed Data : Circulation. 2001 Jul 10;104(2):151-6. PMID: 11447078

Pubmed Data : Environ Int. 2016 Nov ;96:167-172. Epub 2016 Aug 28. PMID: 27690147

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Substances : Flavonoids, Vegetables: All

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Phthalates

[+]

Additional Keywords : Risk Reduction

[+]

These results indicate that flavonoid intake is associated with lower head and neck cancer risk.Jul 18, 2017

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Pubmed Data : J Nutr. 2017 Jul 19. Epub 2017 Jul 19. PMID: 28724656

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Pubmed Data : Mol Nutr Food Res. 2013 Dec ;57(12):2112-27. Epub 2013 Aug 14. PMID: 23943362

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Prev Res (Phila). 2011 Jun ;4(6):907-15. Epub 2011 Mar 7. PMID: 21383028

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8987173. Epub 2018 Aug 5. PMID: 30174782

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Okra

Diseases : Brain Ischemia, Cerebral Ischemia

Pharmacological Actions : Antioxidants, Heme oxygenase-1 inducer, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Nrf2 activation

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Acute cocoa flavanol improves cerebral oxygenation without enhancing executive function at rest or after exercise.Nov 30, 2016

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Pubmed Data : Appl Physiol Nutr Metab. 2016 Dec ;41(12):1225-1232. Epub 2016 Aug 5. PMID: 27849355

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Cocoa, Flavonoids

Therapeutic Actions : Exercise

Pharmacological Actions : Brain-derived neurotrophic factor modulator

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Allomelanins suppress the tumor cell growth in vitro and in vivo.Aug 01, 1997

Pubmed Data : Planta Med. 2008 Dec ;74(15):1769-73. Epub 2008 Nov 12. PMID: 19006051

Click here to read the entire abstract

Pubmed Data : J Food Biochem. 2019 Mar ;43(3):e12744. Epub 2018 Dec 13. PMID: 31353567

Article Published Date : Feb 28, 2019

Study Type : Insect Study

Additional Links

Substances : Apple, Flavonoids

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

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Apple polyphenol extracts prevent damage to human gastric epithelial cells.Jan 31, 2005

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Pubmed Data : Gut. 2005 Feb ;54(2):193-200. PMID: 15647180

Article Published Date : Jan 31, 2005

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Drug-Induced Toxicity: Indomethacin, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Gastroprotective

Additional Keywords : Plant Extracts

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Apples may exert their colon cancer protective effects through favorably altering gene patterns resulting in protection of cells against toxicological insults. Jun 15, 2008

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Pubmed Data : Int J Cancer. 2008 Jun 15;122(12):2647-55. PMID: 18351577

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.May 01, 2010

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Pubmed Data : Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID: 20388778

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Pubmed Data : World J Gastrointest Pharmacol Ther. 2010 Dec 6 ;1(6):123-31. PMID: 21577307

Article Published Date : Dec 06, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Liver Disease

Therapeutic Actions : antioxidant, Hepatoprotective

Additional Keywords : C. Sempervirens Extract, J. Phoenicea Extract, Liver Enzymes, Plant Extracts

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Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2008 Dec;11(6):269-76. PMID: 19000380

Click here to read the entire abstract

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2010;56(1):68-71. PMID: 20354349

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Pubmed Data : Cell Biochem Funct. 2015 Jun ;33(4):202-10. Epub 2015 May 11. PMID: 25962994

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1031-8. Epub 2009 Nov 24. PMID: 19934339

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Pubmed Data : Fitoterapia. 2014 Jun ;95:83-92. Epub 2014 Mar 2. PMID: 24594241

Article Published Date : May 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bergamot orange, Flavonoids

Diseases : Cancer Metastasis, Neuroblastoma

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Eggplant flavonoids exhibit cholesterol-lowering activity in rats.Jan 01, 1997

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Pubmed Data : Plant Foods Hum Nutr. 1997;51(4):321-30. PMID: 9650725

Article Published Date : Jan 01, 1997

Study Type : Animal Study

Additional Links

Substances : Eggplant, Flavonoids

Diseases : Hypercholesterolemia

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Embelia ribes has a cardioprotective effect against isoproterenol-induced myocardial infarcation in rats. Jan 01, 2008

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Pubmed Data : Indian J Exp Biol. 2008 Jan;46(1):35-40. PMID: 18697569

Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.Feb 10, 2009

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Pubmed Data : Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755

Pubmed Data : Life Sci. 1996 ;58(5):PL 87-96. PMID: 8594302

Article Published Date : Dec 31, 1995

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Alcohol Toxicity , Mouse Endogenous Retroviruses

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In vitro and in vivo antioxidant activities of a flavonoid isolated from celery.Dec 31, 2013

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Pubmed Data : Food Funct. 2014 Jan ;5(1):50-6. PMID: 24232123

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

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Substances : Celery, Flavonoids

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

[+]

Intake of fisetin during pregnancy in rats ameliorated in utero mercury exposure induced neurotoxicity outcomes.May 31, 2017

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Pubmed Data : Biol Trace Elem Res. 2017 Jun ;177(2):297-315. Epub 2016 Nov 4. PMID: 27815688

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Fisetin, Flavonoids

Diseases : Mercury Poisoning, Neurodegenerative Diseases, Oxidative Stress, Prenatal Chemical Exposures

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Fisetin, Flavonoids, Mercury Poisoning, Methylmercury, Neurodegenerative diseases, oxidative stress, Prenatal Chemical Exposures

Problem Substances : Mercury

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Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, has antitumorigenic activities in prostate tumor cells. Feb 01, 2009

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Pubmed Data : J Med Food. 2009 Feb;12(1):8-14. PMID: 19298190

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biofactors. 2008;33(1):13-24. PMID: 19276533

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Pubmed Data : Ann Oncol. 2009 Jan;20(1):160-5. Epub 2008 Jul 31. PMID: 19461166

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Microbiol Immunol. 2002 ;46(4):249-55. PMID: 12061627

Article Published Date : Dec 31, 2001

Study Type : Animal Study

Additional Links

Substances : Apple Polyphenols, Catechin , Flavonoids

Diseases : Cholera

Pharmacological Actions : Antidiarrheals, Antimicrobial, Enzyme Inhibitors

Additional Keywords : Dose Response, Plant Extracts

[+]

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.Nov 30, 2006

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Pubmed Data : Neurobiol Dis. 2006 Dec ;24(3):506-15. Epub 2006 Sep 28. PMID: 17010630

Article Published Date : Nov 30, 2006

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Polyphenols, Pomegranate

Pharmacological Actions : Antioxidants

[+]

Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage.Jul 15, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2019 Jul 16 ;24(14). Epub 2019 Jul 16. PMID: 31315278

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 Jul 21 ;21(7). Epub 2016 Jul 21. PMID: 27455216

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Microcirculation. 2017 Oct ;24(7). PMID: 28597598

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Rose

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Rutin inhibits nitric oxide and tumor necrosis factor-alpha production in lipopolysaccharide and concanavalin-a stimulated macrophages.Jan 01, 2007

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Pubmed Data : Drug Metabol Drug Interact. 2007;22(4):263-78. PMID: 18447002

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Rutin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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View the Evidence: 597 Abstracts with Flavonoids Research

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"Dietary flavonoid for preventing colorectal neoplasms."Dec 31, 2011

Cocoa products have blood-pressure lowering capacity.Jan 01, 2010

Dark chocolate is superior to placebo in reducing systolic hypertension or diastolic prehypertension.Jan 01, 2010

Flavonoid intake reduces all-cause mortality.Mar 31, 2015

Flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension.Sep 03, 2015

High intake of flavonols may reduce the risk of colon cancer and high intake of flavones may reduce the risk of rectal cancer.Jul 22, 2018

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

"Kidney function in metabolic syndrome may be improved with Pycnogenol®."May 31, 2010

A Chinese green tea polyphenol extract has evident anti-plaque effect.Sep 01, 2000

A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

A flavonoid supplement improves leg health and reduces fluid retention in premenopausal women. Jan 01, 2004

A flavonol-rich diet may decrease the risk of advanced adenoma recurrence.May 31, 2008

A polyphenol-rich beverage reduces symptoms associated with the common cold.Oct 01, 2010

Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysunfction in smokers.Oct 04, 2005

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils. Sep 09, 2009

Association of total flavonoid intake with hypo-HDL-cholesterolemia among Korean adults: effect modification by polyunsaturated fatty acid intake.Jan 09, 2020

Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

Bilberry has anti-inflammatory properties.Sep 01, 2010

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.Sep 01, 2008

Blueberry flavonoid consumption promotes a positive mood and are a possible way to prevent dysphoria and depression.Feb 19, 2017

Cocoa inhibits LDL oxidation both in vitro and ex vivo.Apr 06, 1999

Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility and increasing serum total antioxidant capacity and HDL-cholesterol concentrations.Nov 01, 2001

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers. Oct 15, 2010

Consumption of flavanone-rich citrus juice in quantities commonly consumed can acutely enhance blood flow to the brain in healthy young adults.Nov 30, 2016

Consumption of high flavanol dark chocolate confers modest improvements in cardiovascular function.Jul 31, 2015

Consumption of phytochemical-rich foods may prevent the development of hypertension.Feb 28, 2015

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.Dec 01, 2008

Dark chocolate improves coronary vasomotion and reduces platelet reactivity.Nov 20, 2007

Dietary flavonoids improve urinary arsenic elimination among Mexican women.Jun 30, 2018

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. Apr 10, 2000

Flavonoid antioxidants may have therapeutic value in PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection.Aug 01, 2009

Flavonoid consumption may be beneficial for disease prevention.May 14, 2017

Flavonoid consumption reduces the risk of esophageal cancer.Jun 01, 2007

Flavonoid-rich dark chocolate improves endothelial function and increases plasma antioxidant concentrations in healthy adults. Jun 01, 2004

Flavonoid-rich dark chocolate intake significantly improved coronary circulation in healthy adults.Jan 24, 2009

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Flavonoids and omega 3-based compoundhad beneficial effects for muscular dystrophies treatment.Dec 31, 2018

Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

Flavonol intake and cognitive decline in middle-aged adults.Nov 30, 2015

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

Higher consumption of red wine, tea, peppers, blueberries and strawberries, was associated with reduced risk of total and cause-specific mortality.Jun 12, 2017

Higher dietary intake of flavonoid may be inversely associated with depressive symptoms.Apr 23, 2018

Higher flavonoid intakes may be associated with lower depression risk.Dec 31, 2015

Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture related hospitalizations in elderly women at high risk of fracture.Aug 11, 2015

Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.Jun 30, 2012

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

Higher intakes of flavonols and flavanones as well as black tea consumption may be associated with lower risk of ovarian cancer.Oct 31, 2014

Higher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men.Aug 02, 2016

Individuals using the Army Physical Fitness Test while supplementing with Pycnogenol had a lower increase in oxidative stress with a faster recovery to almost normal levels.Nov 30, 2013

Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance.Jan 01, 2009

Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly People at high cardiovascular disease risk.Mar 08, 2016

L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with erectile dysfunction without any side effects.May 01, 2003

Moderate consumption of chocolate might be associated with a lower risk of heart failure in male physicians.Nov 30, 2014

Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.Jan 31, 2008

One week of dark chocolate ingestion improved lipid profiles and decreased platelet reactivity within the total group while reducing inflammation only in women.Jul 01, 1999

People who preferentially consume high amounts of quercetin-containing foods have a reduced risk of thrombosis and potential CVD risk.Aug 31, 2006

Prevention of edema in long flights with Pycnogenol.Jun 30, 2005

Prevention of recurrent venous thrombosis and post-thrombotic syndrome.May 31, 2018

Propolis has radioprotective properties.Aug 01, 2009

Pycnogenol has antidiabetic action in patients with type 2 diabetes. Oct 08, 2004

Pycnogenol has therapeutic value in the prevention of jet lag in healthy and hypertensive patients. Oct 01, 2008

Pycnogenol improves allergic rhinitis symptoms when supplementation is started at least 5 weeks before the onset of the allergy season.Aug 01, 2010

Pycnogenol improves diabetes control, lowers cardiovascular disease risk factors, and reduces the need for hypertension medication in type diabetic patients. May 01, 2008

Pycnogenol improves endothelial function of hypertensive patients.Jan 02, 2004

Pycnogenol is effective in treating symptoms associated with menopausal syndrome.Dec 31, 2012

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.Jan 01, 2008

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Pycnogenol prevents damage in the microcirculation of hypertensive patients, and allows the dose of anti-hypertensive drugs to be reduced in most patients.Oct 01, 2006

Flavonoids

View the Evidence:
597 Abstracts with Flavonoids Research