Flavonoids

Name	AC	CK
Hypertension	15	128
Cardiovascular Diseases	17	108
Oxidative Stress	49	93
Inflammation	33	84
Colorectal Cancer	12	83
Endothelial Dysfunction	14	79
Cholesterol: Oxidation	13	61
HDL: Low	4	40
Radiation Induced Illness	12	38
Arteriosclerosis	6	34
Breast Cancer	19	33
Diabetes Mellitus: Type 2: Prevention	4	33
Coronary Artery Disease	5	32
Diabetes Mellitus: Type 2	9	31
Thrombosis	4	31
All-Cause Mortality	2	30
Cardiovascular Disease: Prevention	3	30
Hemorrhoids	3	30
Obesity	7	29
Depression	7	28
Lipopolysaccharide-Induced Toxicity	14	28
DNA damage	12	26
Cognitive Decline/Dysfunction	4	24
Clotting	4	23
Aging	8	22
C-Reactive Protein	3	22
Cancers: All	21	22
Cholesterol: LDL/HDL ratio	3	22
Colon Cancer	18	22
Glaucoma	2	22
Alzheimer's Disease	15	21
Esophageal Cancer	3	21
Allergic Rhinitis	2	20
Cancer Mortality	1	20
Cardiac Mortality	1	20
Chronic Disease	2	20
Deep Vein Thrombosis	2	20
Diabetes: Cardiovascular Illness	2	20
Ocular Hypertension	1	20
Parkinson's Disease	9	20
Prehypertension	1	20
Rectal Cancer	1	20
Smoking	2	20
Liver Cancer	8	18
Colorectal Cancer: Prevention	3	17
Aging: Brain	4	16
Prostate Cancer	13	16
Insulin Resistance	4	15
Lipid Peroxidation	10	15
Metabolic Syndrome X	3	14
Ovarian Cancer	4	14
Chemically-Induced Liver Damage	7	13
Heart Failure	3	13
Lung Cancer	11	13
Myocardial Infarction	3	13
Pesticide Toxicity	3	13
Rheumatoid Arthritis	3	13
Sunburn	3	13
Aging Skin	3	12
Arsenic Poisoning	2	12
Helicobacter Pylori Infection	3	12
Hyperuricemia	2	12
Menopausal Syndrome	2	12
Gout	2	11
High Cholesterol	2	11
Neurodegenerative Diseases	8	11
Skin Diseases: Photo-Aging	2	11
Stroke	2	11
Aflatoxicosis	1	10
Aphthous Ulcer	1	10
Asthma	1	10
Athletic Performance	1	10
Athletic Performance: Recovery	1	10
Bile Duct Cancer	1	10
Bladder Degeneration	1	10
Blood Platelet Disorders	1	10
Bone Fractures	1	10
Brain Edema	1	10
Chemotherapy	1	10
Chronic Obstructive Pulmonary Disease	1	10
Climacteric	1	10
Common Cold	1	10
Dental Caries	1	10
Depression	1	10
Dystrophic retinal detachment (DRD)	1	10
Edema	1	10
Erectile Dysfunction	1	10
Eye Diseases: Vitreous Disorders	1	10
Gallbladder Cancer	1	10
Head and Neck Cancer	1	10
Heart Disease: Ischemic	1	10
Hematuria	1	10
Jet Lag	1	10
Leg Edema	1	10
Libido: Low	1	10
Macular Degeneration	1	10
Osteoarthritis: Knee	1	10
Peripheral vitreochoreoretinal dystrophies (PVCRD)	1	10
Post-Thrombotic Syndrome	1	10
Postmenopausal Disorders: Insomnia	1	10
Postoperative Recovery	1	10
Premenstrual syndrome	1	10
Pulmonary Diseases	1	10
Retinal Detachment	1	10
Sexaul Dysfunction	1	10
Thromboembolism	1	10
Tinnitus	1	10
Venous Thrombosis	1	10
Vericose Veins: Bladder	1	10
Wrinkles	1	10
Hyperlipidemia	5	9
Pancreatic Cancer	5	9
Brain Inflammation	6	8
Cancers: Drug Resistant	7	8
Hyperglycemia	7	8
Cancer Metastasis	4	7
Gastric Ulcer	4	7
Hypercholesterolemia	4	7
Liver Cancer: Prevention	2	7
Breast Cancer: Metastatic	3	6
Cervical Cancer	6	6
Diabetes Mellitus: Type 1	4	6
Myocardial Ischemia	3	6
Breast Cancer: Triple Negative	3	5
Cancers: Multi-Drug Resistant	5	5
Carcinoma: Non-Small-Cell Lung	5	5
Chemotherapy-Induced Toxicity: Cisplatin	3	5
Diabetic Complications	3	5
Melanoma	4	5
Memory Disorders	3	5
Oral Cancer	3	5
Tumors	4	5
Advanced Glycation End products (AGE)	3	4
Aging: Immunosenecence	2	4
Alcohol Toxicity	2	4
Alcoholic Liver Disease	2	4
Anxiety	2	4
Atherosclerosis	3	4
Cerebral Ischemia	2	4
HIV Infections	4	4
High Fat Diet	2	4
Immune Disorders: Low Immune Function	2	4
Inflammatory Bowel Diseases	2	4
Neuroblastoma	2	4
Seizures	2	4
Ultraviolet Radiation Induced Damage	4	4
Allergies	2	3
Brain Injury: Traumatic	2	3
Brain Ischemia	3	3
Cholera	2	3
Dementia	3	3
Diabetes: Cataract	2	3
Dioxin Toxicity	2	3
Dyslipidemias	2	3
Hydrogen Peroxide Induced Toxicity	3	3
Hypoxia	2	3
Liver Damage	2	3
MRSA	2	3
Nonalcoholic fatty liver disease (NAFLD)	2	3
Osteoporosis	2	3
Snake Bite: Venom Toxicity	2	3
Abdominal Obesity (Midsection Fat)	1	2
Aluminum Toxicity	1	2
Anaphylaxis	1	2
Arthritis	1	2
Aspirin-Induced Toxicity	1	2
Autism	1	2
Bladder Cancer	2	2
Bone Diseases	1	2
Brain Injury: Hippocampal Damage	1	2
Brain: Microglial Activation	2	2
Breast Cancer: Lung Metastasis	1	2
Candida Albicans	2	2
Cardiomyopathy	1	2
Cataract	1	2
Cerebral Vasospasm	1	2
Chemotherapy-Induced Toxicity: Gentamicin	1	2
Chikungunya Virus	2	2
Colon Polyps	1	2
Convulsions	1	2
Cystic Fibrosis	2	2
Diabetes: Cognitive Dysfunction	1	2
Diabetic Nephropathy	1	2
Diesel Exhaust Particle Toxicity	1	2
Dopamine Deficiency	1	2
Estrogen Dominance	2	2
Fatty Liver	1	2
Food Allergies	1	2
Fructose-Induced Toxicity	1	2
Giardiasis	2	2
Heat Stroke	1	2
High Fructose Diet	1	2
Hypothyroidism	1	2
IgA Deficiency	1	2
IgE-Mediated Hypersensitivity	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Infertility: Male	1	2
Intestinal Diseases	1	2
Intestinal Permeability	2	2
Iron Overload	1	2
Irritable Bowel Syndrome	1	2
Ischemia	1	2
Kidney Damage: Chemically-Induced	1	2
Leaky Gut Syndrome	2	2
Learning disorders	1	2
Leukemia	2	2
Leukemia: Acute myelogenous leukemia (AML)	1	2
Leukemia: Chronic myelogenous leukemia (CML)	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Immune Function: Thymus Dysfunction	1	2
Lymphoma	1	2
Mercury Poisoning	1	2
Mouse Endogenous Retroviruses	1	2
NSAID-induced toxicity	1	2
Osteoarthritis	1	2
Ovariectomy Associated Adverse Changes	1	2
Periodontitis	1	2
Pesticide-Induced Toxicity: Organophosphates	1	2
Petroleum Exposure And Toxicity	1	2
Prenatal Chemical Exposures	1	2
Prenatal Nutrition: Health of the Offspring	1	2
Promyelocytic leukemia	2	2
Prostatic Hyperplasia: Benign	1	2
Radiation Induced Illness: Bone Marrow	1	2
Scars	1	2
Skin Cancer	1	2
Skin Cancer: Prevention	1	2
Sperm Quality: Low	1	2
Squamous cell carcinoma	1	2
Staphylococcus aureus infection	2	2
Systemic Lupus Erythematosus	1	2
Thyroid Cancer	2	2
Wound Healing	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Allergic Airway Diseases	1	1
Amyloidosis	1	1
Amyotrophic Lateral Sclerosis	1	1
Anemia: Hemolytic	1	1
Aspergillosis	1	1
Bacillus subtilis infections	1	1
Bacterial Infections	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Brain: Oxidative Stress	1	1
Cancers	1	1
Candida Infection	1	1
Chemotherapy and Radiation Toxicity	1	1
Cholangiocarcinoma	1	1
Chronic Myeloid Leukemia	1	1
Clostridium Infections	1	1
Colitis	1	1
Copper Toxicity	1	1
Cryptosporidiosis	1	1
Cytomegalovirus Infections	1	1
Epstein-Barr Virus Infections	1	1
Escherichia coli Infections	1	1
Excitotoxicity	1	1
Fatigue	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
Glucosephosphate Dehydrogenase Deficiency	1	1
HSV-1	1	1
HSV-2	1	1
High Homocysteine	1	1
Hyperinsulinism	1	1
Hypertension: Pulmonary	1	1
Influenza in Swine	1	1
Kidney Damage: Drug-Induced	1	1
Klebsiella Infections	1	1
Leishmaniasis	1	1
Liver Disease	1	1
Malaria	1	1
Malignant Melanoma	1	1
Micrococcus luteus infections	1	1
Mycobacterium tuberculosis	1	1
Neurological Conditions	1	1
Non-Small-Cell Lung Carcinoma	1	1
Osteosarcoma	1	1
Protozoan Infections	1	1
Pseudomonas aeruginosa	1	1
Psychiatric Disorders	1	1
Radiation	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Rhinovirus Infection	1	1
Schizophrenia	1	1
Simian virus 40 (SV40)	1	1
Staphylococcus epidermidis	1	1
Sugar (Sucrose) Toxicity	1	1
Swine Flu Associated Virus	1	1
Tertiary butyl hydroperoxide toxicity	1	1
Testicular Cancer	1	1
Triglycerides: Elevated	1	1
Vibrio Infections	1	1
Weight Problems	1	1

Name	AC	CK
Antioxidants	147	310
Chemopreventive	37	116
Anti-Inflammatory Agents	51	94
Antiproliferative	64	81
Apoptotic	66	79
Neuroprotective Agents	36	68
Platelet Aggregation Inhibitors	7	62
NF-kappaB Inhibitor	22	46
Tumor Necrosis Factor (TNF) Alpha Inhibitor	22	46
Anticarcinogenic Agents	22	40
Hypotensive	2	40
Cell cycle arrest	27	39
Hypoglycemic Agents	15	39
Cyclooxygenase 2 Inhibitors	21	38
Cardioprotective	11	36
Interleukin-1 beta downregulation	15	34
Antineoplastic Agents	21	33
Anti-Apoptotic	15	32
Radioprotective	12	29
Antidepressive Agents	6	27
Hepatoprotective	14	26
Interleukin-6 Downregulation	15	26
Analgesics	4	24
Antihypertensive Agents	5	24
Vasodilator Agents	4	23
Enzyme Inhibitors	17	21
Anti-metastatic	11	19
Anticholesteremic Agents	4	15
Chemotherapeutic	12	13
MicroRNA modulator	3	13
Anti-Allergic Agents	2	12
Anti-Platelet	2	11
Nitric Oxide Enhancer	2	11
Anti Inflammatory	2	10
Anti-Bacterial Agents	9	10
Anti-thrombotic	1	10
Calcium Channel Blockers	1	10
Cardiovascular Agents	1	10
Detoxifier	1	10
Hypolipidemic	7	10
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	10
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	10
Chemosensitizer	8	9
Immunomodulatory	5	9
Tumor Suppressor Protein p53 Upregulation	8	9
Anti-Ulcer Agents	4	8
Antiviral Agents	7	7
Matrix metalloproteinase-2 (MMP-2) inhibitor	4	7
Alpha-glucosidase inhibitor	4	5
Anti-Angiogenic	4	5
Antifungal Agents	5	5
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor	1	5
Interleukin-10 downregulation	3	5
Nitric Oxide Inhibitor	3	5
Nrf2 activation	3	5
Photoprotective	4	5
Renoprotective	3	5
Anti-Anxiety Agents	2	4
Anticonvulsants	2	4
Antimutagenic Agents	4	4
Brain-derived neurotrophic factor modulator	2	4
Chemoprotective Agents	2	4
Genoprotective	3	4
Malondialdehyde Down-regulation	2	4
Phase II Detoxification Enzyme Inducer	2	4
Anti-HIV Agents	3	3
Antimicrobial	2	3
Cyclooxygenase 1 Inhibitor	2	3
Cytoprotective	2	3
5-Lipoxygenase Inhibitor	2	2
Aldose reductase inhibitor	1	2
Alpha-amylase inhibitor	2	2
Anti-Tumor	1	2
Antidiarrheals	1	2
Antinoceceptive	1	2
Caspase-3 Activation	2	2
Cyclooxygenase Inhibitors	1	2
Cytotoxic	2	2
Dopaminergic	1	2
Gastroprotective	2	2
Heme oxygenase-1 up-regulation	1	2
Interferon Gamma Reducer	1	2
Interleukin-4 downregulation	2	2
Iron Chelating Agents	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	2
Proteasome Inhibitors	2	2
Superoxide Dismutase Up-regulation	1	2
Vascular Cell Adhesion Molecule-1 Inhibitor	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Acetylcholinesterase Inhibitor	1	1
Anti-Estrogenic	1	1
Antiprotozoal Agents	1	1
Aromatase Inhibitors	1	1
Cytotoxicity	1	1
DNA Repair Up-regulation	1	1
E-cadherin down-regulation	1	1
Estrogen Receptor Agonist	1	1
Expectorants	1	1
Forkhead Transcription Factor Family O (FOXO) Modulator	1	1
Gastrointestinal Agents	1	1
Glucagon Like Peptide 1 (GLP-1) Down-Regulation	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Gluconeogenesis Inhibitor	1	1
Glutathione Upregulation	1	1
Histamine Antagonists	1	1
Histone deacetylase inhibitor	1	1
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	1
Immunostimulatory	1	1
Insulin-releasing	1	1
Interleukin-5 downregulation	1	1
Leishmanicidal	1	1
Leukotriene Antagonists	1	1
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	1
Metal Chelation: Copper	1	1
Neurominidase Inhibitor	1	1
Osteoprotective	1	1
P-glycoprotein Inhibitors	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Postaglandin PGE2 downregulation	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Sedative effects	1	1
Telomere Protective	1	1
Topoisomerase II Inhibitor	1	1
Vasoprotective	1	1
Wnt/β-catenin signaling pathway modulation	1	1
Xanthine oxidase inhibitor	1	1
interleukin-13 down-regulation	1	1

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Jul 23 ;10(7). Epub 2018 Jul 23. PMID: 30041489

Article Published Date : Jul 22, 2018

Study Type : Meta Analysis

Additional Links

Substances : Apigenin, Flavonoids, Quercetin

Diseases : Colorectal Cancer, Rectal Cancer

Pharmacological Actions : Chemopreventive

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Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

Click here to read the entire abstract

Pubmed Data : Medicine (Baltimore). 2018 May ;97(19):e0686. PMID: 29742713

Click here to read the entire abstract

Pubmed Data : Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Sep;35(5):383-4. PMID: 11780252

Article Published Date : Sep 01, 2000

Study Type : Human Study

Additional Links

Substances : Flavonoids, Green Tea, Polyphenols

Diseases : Dental Caries

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A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2008 Apr 14;14(14):2187-93. PMID: 18407592

Article Published Date : Apr 14, 2008

Study Type : Human Study

Additional Links

Substances : Apigenin, Catechin , Flavonoids

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

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Pubmed Data : Clin Ther. 2005 Jun;27(6):746-54. PMID: 16117981

Article Published Date : Jun 01, 2005

Study Type : Human Study

Additional Links

Substances : Diosmin , Flavonoids, Hesperidin

Diseases : Hemorrhoids

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A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

Pubmed Data : J Agric Food Chem. 2009 Sep 9;57(17):7743-9. PMID: 19691323

Article Published Date : Sep 09, 2009

Study Type : Human Study

Additional Links

Substances : Apples, Flavonoids, Polyphenols

Diseases : Helicobacter Pylori Infection

Additional Keywords : Plant Extracts, Proanthocyanidins

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Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Altern Complement Med. 2008 May ;14(4):423-5. PMID: 18576924

Article Published Date : Apr 30, 2008

Study Type : Human Study

Additional Links

Substances : Bitter Orange, Flavonoids, Naringenin

Therapeutic Actions : Acupressure: Auricular

Additional Keywords : Absorption

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Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9033-8. Epub 2009 May 18. PMID: 17344491

Click here to read the entire abstract

Pubmed Data : Nutr Res. 2018 Jul ;55:65-71. Epub 2018 Apr 21. PMID: 29914629

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2007 Jun;21(6):501-6. PMID: 19444905

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Neurol. 2019 ;10:755. Epub 2019 Jul 23. PMID: 31396142

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Flavonoids, Omega-3 Fatty Acids

Diseases : Muscular Dystrophies

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

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Pubmed Data : Br J Nutr. 2016 Oct ;116(7):1275-1287. Epub 2016 Sep 21. PMID: 27650133

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2008 Feb ;29(2):411-7. Epub 2008 Jan 12. PMID: 18192689

Article Published Date : Jan 31, 2008

Click here to read the entire abstract

Pubmed Data : Clin Appl Thromb Hemost. 2005 Jul ;11(3):289-94. PMID: 16015414

Click here to read the entire abstract

Pubmed Data : Life Sci. 2004 Oct 8;75(21):2505-13. PMID: 15363656

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Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Microbiol Biotechnol. 2017 Jul 28 ;27(7):1257-1265. PMID: 28535611

Article Published Date : Jul 27, 2017

Study Type : Human Study

Additional Links

Substances : Flavonoids, Kaempferol, Quercetin, Sea buckthorn

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

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Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.Jul 10, 2001

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Pubmed Data : Circulation. 2001 Jul 10;104(2):151-6. PMID: 11447078

Pubmed Data : Environ Int. 2016 Nov ;96:167-172. Epub 2016 Aug 28. PMID: 27690147

Article Published Date : Oct 31, 2016

Study Type : Human Study

Additional Links

Substances : Flavonoids, Vegetables: All

Diseases : Breast Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Phthalates

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Additional Keywords : Risk Reduction

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These results indicate that flavonoid intake is associated with lower head and neck cancer risk.Jul 18, 2017

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Pubmed Data : J Nutr. 2017 Jul 19. Epub 2017 Jul 19. PMID: 28724656

Article Published Date : Jul 18, 2017

Study Type : Human Study

Additional Links

Substances : Anthocyanins, Flavonoids

Diseases : Head and Neck Cancer

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

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This pilot study provides the first evidence of miRNA modulation by diet and other factors, that can be detected consistently in both plasma and stools samples.Aug 31, 2014

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Pubmed Data : Mutagenesis. 2014 Sep ;29(5):385-91. PMID: 25150024

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Pubmed Data : Mol Nutr Food Res. 2013 Dec ;57(12):2112-27. Epub 2013 Aug 14. PMID: 23943362

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Prev Res (Phila). 2011 Jun ;4(6):907-15. Epub 2011 Mar 7. PMID: 21383028

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Med Food. 2014 Jan ;17(1):92-102. PMID: 24456359

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2008 Jun 15;122(12):2647-55. PMID: 18351577

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.May 01, 2010

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Pubmed Data : Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID: 20388778

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Pubmed Data : World J Gastrointest Pharmacol Ther. 2010 Dec 6 ;1(6):123-31. PMID: 21577307

Article Published Date : Dec 06, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Liver Disease

Therapeutic Actions : antioxidant, Hepatoprotective

Additional Keywords : C. Sempervirens Extract, J. Phoenicea Extract, Liver Enzymes, Plant Extracts

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Click here to read the entire abstract

Pubmed Data : Nutr Neurosci. 2008 Dec;11(6):269-76. PMID: 19000380

Click here to read the entire abstract

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2010;56(1):68-71. PMID: 20354349

Click here to read the entire abstract

Pubmed Data : Cell Biochem Funct. 2015 Jun ;33(4):202-10. Epub 2015 May 11. PMID: 25962994

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Dec;2(12):1031-8. Epub 2009 Nov 24. PMID: 19934339

Fenugreek (Trigonella foenum graecum) seed polyphenols protects the liver from alcohol toxicity. Apr 01, 2007

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Pubmed Data : Pharmazie. 2007 Apr;62(4):299-304. PMID: 17484288

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : Fenugreek, Flavonoids, Polyphenols

Diseases : Alcohol Toxicity , Alcoholic Liver Disease

Pharmacological Actions : Phase II Detoxification Enzyme Inducer

Additional Keywords : Plant Extracts

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Fig fruit has antioxidant and immunostimulatory properties. Jun 01, 2009

Click here to read the entire abstract

Pubmed Data : Plant Foods Hum Nutr. 2009 Jun;64(2):167-73. PMID: 19466553

Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.Feb 10, 2009

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Pubmed Data : Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755

Pubmed Data : Life Sci. 1996 ;58(5):PL 87-96. PMID: 8594302

Article Published Date : Dec 31, 1995

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Alcohol Toxicity , Mouse Endogenous Retroviruses

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Intake of fisetin during pregnancy in rats ameliorated in utero mercury exposure induced neurotoxicity outcomes.May 31, 2017

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Pubmed Data : Biol Trace Elem Res. 2017 Jun ;177(2):297-315. Epub 2016 Nov 4. PMID: 27815688

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Fisetin, Flavonoids

Diseases : Mercury Poisoning, Neurodegenerative Diseases, Oxidative Stress, Prenatal Chemical Exposures

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Fisetin, Flavonoids, Mercury Poisoning, Methylmercury, Neurodegenerative diseases, oxidative stress, Prenatal Chemical Exposures

Problem Substances : Mercury

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Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, has antitumorigenic activities in prostate tumor cells. Feb 01, 2009

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Pubmed Data : J Med Food. 2009 Feb;12(1):8-14. PMID: 19298190

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Pubmed Data : Biomed Res Int. 2015 ;2015:381040. Epub 2015 Jan 5. PMID: 25629046

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Moringa oleifera

Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation

Additional Keywords : Plant Extracts

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Lychee fruit extract suppressed the expression of inflammatory genes, resulting in anti-inflammatory effects through its inhibition of NF-κB activation and mRNA interactions.Dec 31, 2013

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Pubmed Data : Nutrients. 2019 Mar 7 ;11(3). Epub 2019 Mar 7. PMID: 30866491

Article Published Date : Mar 06, 2019

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Pubmed Data : Biofactors. 2008;33(1):13-24. PMID: 19276533

Article Published Date : Jan 01, 2008

Study Type : Animal Study

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Substances : Flavonoids, Mango , Muskmelon, Polyphenols, Vitamin C, Watermelon

Diseases : Arteriosclerosis, Dyslipidemias, Hyperglycemia, Hypothyroidism, Oxidative Stress

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Plant Extracts

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Nobiletin supplementation inhibited activation of apoptotic pathways and DNA damage.May 18, 2015

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Pubmed Data : Exp Toxicol Pathol. 2015 May 19. Epub 2015 May 19. PMID: 26002685

Article Published Date : May 18, 2015

Study Type : Animal Study

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Substances : Flavonoids, Nobiletin

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, DNA damage

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective

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Pterocarpus marsupium exhibits antihyperlipidemic activities. Feb 01, 2006

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Pubmed Data : Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 8377021

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The flavonoids diosmin and hesperidin inhibit experimentally-induced oral carcinogenesis in rats. Jan 15, 1997

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Pubmed Data : Cancer Res. 1997 Jan 15;57(2):246-52. PMID: 9000563

Article Published Date : Jan 15, 1997

Study Type : Animal Study

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Substances : Diosmin , Flavonoids, Hesperidin

Diseases : Oral Cancer

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The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow.Aug 26, 2002

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Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):37-48. PMID: 12160890

Article Published Date : Aug 26, 2002

Study Type : Animal Study

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Substances : Flavonoids, Grapefruit, Naringenin

Diseases : DNA damage, Radiation Induced Illness, Radiation Induced Illness: Bone Marrow

Pharmacological Actions : Antioxidants, Radioprotective

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The phytochemical synergy among the constituents of Graviola leaf extracts protected against prostate cancer, and enhanced the bioavailability of rutin 7-fold and quercetin 3-fold.Apr 10, 2015

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Pubmed Data : Carcinogenesis. 2015 Apr 11. Epub 2015 Apr 11. PMID: 25863125

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Pubmed Data : Nutrients. 2016 Jul 8 ;8(7). Epub 2016 Jul 8. PMID: 27399769

Article Published Date : Jul 07, 2016

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Rose

Diseases : Liver Injury: Ischemia/reperfusion

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

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These results confirm that myricetin exerts neuroprotective effect in experimental Parkinson's disease.May 31, 2018

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Pubmed Data : Front Biosci (Elite Ed). 2018 Jun 1 ;10:481-494. Epub 2018 Jun 1. PMID: 29772521

Article Published Date : May 31, 2018

Study Type : Insect Study

Additional Links

Substances : Flavonoids, Myricetin, Seaweed: Brown

Diseases : Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

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View the Evidence: 538 Abstracts with Flavonoids Research

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"Dietary flavonoid for preventing colorectal neoplasms."Dec 31, 2011

Cocoa products have blood-pressure lowering capacity.Jan 01, 2010

Dark chocolate is superior to placebo in reducing systolic hypertension or diastolic prehypertension.Jan 01, 2010

Flavonoid intake reduces all-cause mortality.Mar 31, 2015

Flavonoids have a promising role in improving visual function in patients with glaucoma and ocular hypertension.Sep 03, 2015

High intake of flavonols may reduce the risk of colon cancer and high intake of flavones may reduce the risk of rectal cancer.Jul 22, 2018

Higher intakes of total flavonoids and subclasses are associated with lower risk of T2DM.Apr 30, 2018

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

"Kidney function in metabolic syndrome may be improved with Pycnogenol®."May 31, 2010

A Chinese green tea polyphenol extract has evident anti-plaque effect.Sep 01, 2000

A combination of apigenin and EGCG prevent colorectal cancer recurrence. Apr 14, 2008

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A combination of pine bark extract and nattokinase prevents venous thrombosis in long-haul flights.Sep 01, 2003

A flavonoid supplement improves leg health and reduces fluid retention in premenopausal women. Jan 01, 2004

A flavonol-rich diet may decrease the risk of advanced adenoma recurrence.May 31, 2008

A polyphenol-rich beverage reduces symptoms associated with the common cold.Oct 01, 2010

Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysunfction in smokers.Oct 04, 2005

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils. Sep 09, 2009

Auricular acupressure at some specific acupoints can significantly improve the absorption of naringenin and hesperetin in the extracts form C. aurantium L.Apr 30, 2008

Bilberry has anti-inflammatory properties.Sep 01, 2010

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.Sep 01, 2008

Blueberry flavonoid consumption promotes a positive mood and are a possible way to prevent dysphoria and depression.Feb 19, 2017

Cocoa inhibits LDL oxidation both in vitro and ex vivo.Apr 06, 1999

Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility and increasing serum total antioxidant capacity and HDL-cholesterol concentrations.Nov 01, 2001

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers. Oct 15, 2010

Consumption of flavanone-rich citrus juice in quantities commonly consumed can acutely enhance blood flow to the brain in healthy young adults.Nov 30, 2016

Consumption of high flavanol dark chocolate confers modest improvements in cardiovascular function.Jul 31, 2015

Consumption of phytochemical-rich foods may prevent the development of hypertension.Feb 28, 2015

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.Dec 01, 2008

Dark chocolate improves coronary vasomotion and reduces platelet reactivity.Nov 20, 2007

Dietary flavonoids improve urinary arsenic elimination among Mexican women.Jun 30, 2018

Flavanone intake is inversely associated with esophageal cancer risk and may account, with vitamin C, for the protective effect of fruit, especially citrus fruit, on esophageal cancer. Apr 10, 2000

Flavonoid antioxidants may have therapeutic value in PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection.Aug 01, 2009

Flavonoid consumption may be beneficial for disease prevention.May 14, 2017

Flavonoid consumption reduces the risk of esophageal cancer.Jun 01, 2007

Flavonoid-rich dark chocolate improves endothelial function and increases plasma antioxidant concentrations in healthy adults. Jun 01, 2004

Flavonoid-rich dark chocolate intake significantly improved coronary circulation in healthy adults.Jan 24, 2009

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Flavonoids and omega 3-based compoundhad beneficial effects for muscular dystrophies treatment.Dec 31, 2018

Flavonoids from vegetables and fruits may be linked with the reduced risk of colorectal cancer.Sep 30, 2016

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

Higher consumption of red wine, tea, peppers, blueberries and strawberries, was associated with reduced risk of total and cause-specific mortality.Jun 12, 2017

Higher dietary intake of flavonoid may be inversely associated with depressive symptoms.Apr 23, 2018

Higher flavonoid intakes may be associated with lower depression risk.Dec 31, 2015

Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture related hospitalizations in elderly women at high risk of fracture.Aug 11, 2015

Higher intake of flavonoids, particularly from berries, appears to reduce rates of cognitive decline in older adults.Jun 30, 2012

Higher intakes of anthocyanins and flavonols and their anti-inflammatory effects may be a key component underlying the reduction in risk of certain chronic diseases.May 26, 2015

Higher intakes of flavonols and flavanones as well as black tea consumption may be associated with lower risk of ovarian cancer.Oct 31, 2014

Higher intakes of fruit-based flavonoids were associated with a lower risk of nonfatal MI and ischemic stroke in men.Aug 02, 2016

Individuals using the Army Physical Fitness Test while supplementing with Pycnogenol had a lower increase in oxidative stress with a faster recovery to almost normal levels.Nov 30, 2013

Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance.Jan 01, 2009

Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly People at high cardiovascular disease risk.Mar 08, 2016

L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with erectile dysfunction without any side effects.May 01, 2003

Moderate consumption of chocolate might be associated with a lower risk of heart failure in male physicians.Nov 30, 2014

Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.Jan 31, 2008

One week of dark chocolate ingestion improved lipid profiles and decreased platelet reactivity within the total group while reducing inflammation only in women.Jul 01, 1999

People who preferentially consume high amounts of quercetin-containing foods have a reduced risk of thrombosis and potential CVD risk.Aug 31, 2006

Prevention of edema in long flights with Pycnogenol.Jun 30, 2005

Prevention of recurrent venous thrombosis and post-thrombotic syndrome.May 31, 2018

Propolis has radioprotective properties.Aug 01, 2009

Pycnogenol has antidiabetic action in patients with type 2 diabetes. Oct 08, 2004

Pycnogenol has therapeutic value in the prevention of jet lag in healthy and hypertensive patients. Oct 01, 2008

Pycnogenol improves allergic rhinitis symptoms when supplementation is started at least 5 weeks before the onset of the allergy season.Aug 01, 2010

Pycnogenol improves diabetes control, lowers cardiovascular disease risk factors, and reduces the need for hypertension medication in type diabetic patients. May 01, 2008

Pycnogenol improves endothelial function of hypertensive patients.Jan 02, 2004

Pycnogenol is effective in treating symptoms associated with menopausal syndrome.Dec 31, 2012

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.Jan 01, 2008

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Pycnogenol prevents damage in the microcirculation of hypertensive patients, and allows the dose of anti-hypertensive drugs to be reduced in most patients.Oct 01, 2006

Pycnogenol relieves symptoms of tinnitus by improving cochlear flow.Jun 01, 2010

Pycnogenol supplementation benefits human skin by increasing skin hydration and skin elasticity. Dec 31, 2011

Flavonoids

View the Evidence:
538 Abstracts with Flavonoids Research