Genipin

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1 Diseases Researched for Genipin
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Breast Cancer11Locked
1 Pharmacological Actions Researched for Genipin
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Chemopreventive11Locked

View the Evidence:
42 Abstracts with Genipin Research

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A natural compound mixture ameliorates psoriasis-like skin lesions.Dec 31, 2019

Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:9416962. Epub 2020 Oct 22. PMID: 33149756
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid, Emodin, Genipin, Ginsenosides
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation.Jan 31, 2018

Pubmed Data : FEBS J. 2018 Feb ;285(3):501-517. Epub 2017 Dec 26. PMID: 29197188
Article Published Date : Jan 31, 2018
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Hyperlipidemia
Pharmacological Actions : Hepatoprotective, Hypolipidemic, MicroRNA modulator
[+]

Genipin ameliorates diet-induced obesity via promoting lipid mobilization and browning of white adipose tissue.Jan 28, 2018

Pubmed Data : Phytother Res. 2018 Jan 29. Epub 2018 Jan 29. PMID: 29377296
Article Published Date : Jan 28, 2018
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Obesity Agents
[+]

Genipin ameliorates hypertension-induced renal damage.Jun 30, 2016

Pubmed Data : Fitoterapia. 2016 Jul ;112:244-53. Epub 2016 Jun 23. PMID: 27343367
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Hypertension, Kidney Damage
Pharmacological Actions : Antihypertensive Agents, Renoprotective
[+]

Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses.Oct 22, 2019

Pubmed Data : Inflammopharmacology. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646411
Article Published Date : Oct 22, 2019
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Genipin enhances the antitumor effect of elesclomol in A549 lung cancer cells.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2020 Dec ;20(6):374. Epub 2020 Oct 21. PMID: 33154772
Article Published Date : Nov 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Lung Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Genipin enhances the therapeutic effects of oxaliplatin by upregulating BIM in colorectal cancer.Feb 19, 2019

Pubmed Data : Mol Cancer Ther. 2019 Feb 20. Epub 2019 Feb 20. PMID: 30787174
Article Published Date : Feb 19, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Genipin has significant gastroprotective effects and might be useful for treating and preventing gastric lesions.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2017 ;40(2):151-154. PMID: 28154253
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Gastric Ulcer, Gastrointestinal Diseases
Pharmacological Actions : Gastroprotective
[+]

Genipin inhibited LPS-induced inflammatory response by activating Nrf2 signalling pathway in BV2 microglia.Sep 30, 2017

Pubmed Data : Neurochem Res. 2017 Oct ;42(10):2769-2776. Epub 2017 May 11. PMID: 28497344
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Genipin inhibits allergic responses in ovalbumin-induced asthmatic mice.Nov 30, 2017

Pubmed Data : Int Immunopharmacol. 2017 Dec ;53:49-55. Epub 2017 Oct 15. PMID: 29035815
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Cyclooxygenase 2 Inhibitors, interleukin-13 down-regulation, Interleukin-5 downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Genipin inhibits the growth of human bladder cancer cells.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Feb ;15(2):2619-2624. Epub 2017 Dec 11. PMID: 29434982
Article Published Date : Jan 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Genipin may be a promising preventative treatment to slow the degradation of cartilage.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Orthop Res. 2015 Nov ;33(11):1571-1579. Epub 2015 May 18. PMID: 25939430
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Cartilage Diseases
Pharmacological Actions : Osteoprotective
Additional Keywords : Plant Extracts
[+]

Genipin may provide a novel therapeutic option for preventing and treating infants with bronchopulmonary dysplasia.Dec 31, 2018

Pubmed Data : Nutrition. 2019 Jan ;57:237-244. Epub 2018 Jun 19. PMID: 30196116
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Bronchopulmonary Dysplasia, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Genipin may represent a promising immunomodulatory therapeutic candidate for hepatocellular carcinoma.Jul 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Jul 12 ;7(28):43792-43804. PMID: 27270308
Article Published Date : Jul 11, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Immunomodulatory
[+]

Genipin might be a potential therapeutic agent for the treatment of sepsis.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2016 Mar ;173(6):980-91. Epub 2016 Feb 10. PMID: 26660048
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Liver Damage, Sepsis
Pharmacological Actions : Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Genipin modulates monoaminergic transmission and levels of brain-derived neurotrophic factor in rat model of depression.Sep 04, 2014

Pubmed Data : Neuroscience. 2014 Sep 5 ;275:365-73. Epub 2014 Jun 24. PMID: 24972301
Article Published Date : Sep 04, 2014
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
Additional Keywords : Phytotherapy
[+]

Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1.Mar 08, 2018

Pubmed Data : Epigenetics. 2018 Mar 9:1-22. Epub 2018 Mar 9. PMID: 29522357
Article Published Date : Mar 08, 2018
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Brain-derived neurotrophic factor modulator
[+]

Genipin protects against cerebral ischemia-reperfusion injury.Feb 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Feb 15 ;845:56-64. Epub 2018 Dec 21. PMID: 30582911
Article Published Date : Feb 14, 2019
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Cerebral Ischemia
Pharmacological Actions : Neuroprotective Agents
[+]

Genipin protects the liver from ischemia-reperfusion injury by modulating mitochondrial quality control.Dec 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2017 08 1 ;328:25-33. Epub 2017 May 3. PMID: 28477916
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Lipid Peroxidation, Liver Injury: Ischemia/reperfusion , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
[+]

Genipin Reverses high fat diet-induced liver damage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;49(5):1885-1897. Epub 2018 Sep 20. PMID: 30235442
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : High Fat Diet, Liver Damage, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway.Nov 23, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 24 ;8(60):101952-101964. Epub 2017 Oct 16. PMID: 29254217
Article Published Date : Nov 23, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Geniposide and genipin have a healthy promotion to eradicate H. pylori infections.Nov 30, 2017

Pubmed Data : J Food Sci. 2017 Dec ;82(12):3021-3028. Epub 2017 Nov 14. PMID: 29135040
Article Published Date : Nov 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interferon Gamma Reducer, Interleukin-1 beta downregulation
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Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3 inflammasome activation.Dec 01, 2019

Pubmed Data : Eur J Pharmacol. 2019 Dec 2:172800. Epub 2019 Dec 2. PMID: 31805268
Article Published Date : Dec 01, 2019
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastroprotective
[+]

These findings suggest that genipin protects against apoptosis and inflammation in lipopolysaccharide-induced acute lung injury by promoting autophagy.Apr 04, 2019

Pubmed Data : Int Immunopharmacol. 2019 Apr 5 ;72:21-30. Epub 2019 Apr 5. PMID: 30959368
Article Published Date : Apr 04, 2019
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A review of the therapeutic potential of genipin in central neurodegenerative diseases.Sep 30, 2016

Pubmed Data : CNS Drugs. 2016 Oct ;30(10):889-97. PMID: 27395402
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : Genipin
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hypoglycemic Agents, Neuroprotective Agents
[+]

Effects of short-duration treatment of cartilage with punicalagin and genipin and the implications for treatment of osteoarthritis.Oct 25, 2020

Pubmed Data : J Biomed Mater Res B Appl Biomater. 2020 Oct 26. Epub 2020 Oct 26. PMID: 33103838
Article Published Date : Oct 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Genipin, Punicalagin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Osteoprotective
[+]

Fluoxetine increased the migratory distance of liver cancer cells, but is counteracted by ginipin. Dec 13, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Dec 14 ;23(12). Epub 2018 Dec 14. PMID: 30558243
Article Published Date : Dec 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Cancer Metastasis, Liver Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Increased Risk, Risk Reduction
Problem Substances : Fluoxetine (trade name Prozac)
[+]

Genipin alleviates LPS-induced acute lung injury by inhibiting NF-κB and NLRP3 signaling pathways.Aug 31, 2016

Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:115-9. Epub 2016 Jun 2. PMID: 27262946
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Genipin attenuates cisplatin-induced nephrotoxicity.Aug 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Sep ;93:1083-1097. Epub 2017 Jul 20. PMID: 28738532
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Genipin attenuates LPS-induced changes of emotional behaviours through inhibition of neural activation and inflammatory responses.Oct 14, 2014

Pubmed Data : Eur J Pharmacol. 2014 Oct 15 ;741:1-7. Epub 2014 Jul 30. PMID: 25084220
Article Published Date : Oct 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion.Nov 30, 2014

Pubmed Data : Biochimie. 2014 Dec ;107 Pt B:391-5. PMID: 25457105
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Periodontal Diseases
Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Genipin induces cell death via intrinsic apoptosis pathways in human glioblastoma cells.Aug 29, 2018

Pubmed Data : J Cell Biochem. 2018 Aug 30. Epub 2018 Aug 30. PMID: 30160798
Article Published Date : Aug 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.Dec 10, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 Dec 11 ;5:17935. Epub 2015 Dec 11. PMID: 26659006
Article Published Date : Dec 10, 2015
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Autophagy Up-regulation
[+]

Genipin may be used as a novel therapeutic agent in the treatment of colon cancer .Aug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Sep ;16(3):2957-2964. Epub 2018 Jun 26. PMID: 30127884
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Genipin protects against H2O2-induced oxidative damage in retinal pigment epithelial cells by promoting Nrf2 signaling.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2019 Feb ;43(2):936-944. Epub 2018 Dec 12. PMID: 30569096
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Hydrogen Peroxide Induced Toxicity, Macular Degeneration
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury.Oct 04, 2017

Pubmed Data : Eur J Pharmacol. 2017 Oct 5 ;812:128-137. Epub 2017 Jul 11. PMID: 28709622
Article Published Date : Oct 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
[+]

Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Immunol. 2015 Sep ;297(1):40-5. Epub 2015 Jun 16. PMID: 26123077
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Potential role of genipin in cancer therapy.Dec 31, 2017

Pubmed Data : Pharmacol Res. 2018 07 ;133:195-200. Epub 2018 May 24. PMID: 29758279
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Substances : Genipin
Diseases : Cancers: All
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemotherapeutic
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Shorter the Genipin treatment before Cisplatin better promoted the cisplatin induced ROS and subsequent cell death.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Med Sci. 2016 ;13(7):507-16. Epub 2016 Jun 29. PMID: 27429587
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

The present review may provide information on the use of these natural compounds for the prevention of breast cancer.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Prev. 2015 Dec ;20(4):223-31. Epub 2015 Dec 30. PMID: 26734584
Article Published Date : Nov 30, 2015
Study Type : Review
Additional Links
Substances : Capsaicin, Curcumin, Genipin, Lycopene, Ursolic Acid
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
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These results provide new insights into the potential role of genipin in suppressing colon cancer progression.May 31, 2018

Pubmed Data : Food Chem Toxicol. 2018 Jun ;116(Pt B):70-76. Epub 2018 Apr 6. PMID: 29630948
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Cancer Metastasis, Colon Cancer, Hypoxia
Pharmacological Actions : Anti-metastatic, Vascular Endothelial Growth Factor A Inhibitor
[+]

This describes the chemopreventive properties of genipin on AGS cell line.Dec 31, 2015

Pubmed Data : J Biochem Mol Toxicol. 2016 Jan ;30(1):45-54. Epub 2015 Sep 17. PMID: 26377927
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Genipin
Diseases : Gastric Cancer, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

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