Ginsenosides

Name	AC	CK
Oxidative Stress	38	72
Liver Cancer	35	71
Alzheimer's Disease	42	66
Lung Cancer	37	56
Inflammation	37	51
Stroke: Ischemic	8	47
Colorectal Cancer	16	45
Lipopolysaccharide-Induced Toxicity	30	44
Depression	21	41
Obesity	25	41
Myocardial Ischemia	19	40
Carcinoma: Non-Small-Cell Lung	8	37
Cancers: All	23	35
Breast Cancer	29	34
Parkinson's Disease	11	32
Gastric Cancer	9	28
Cognitive Decline/Dysfunction	14	26
Brain Ischemia	9	25
Memory Disorders	13	25
Pancreatic Cancer	4	25
Cancers: Drug Resistant	14	24
Esophageal Cancer	4	24
Cerebral Ischemia	14	23
Chemotherapy-Induced Toxicity: Cisplatin	13	23
Diabetes Mellitus: Type 2	16	23
Chemically-Induced Liver Damage	12	22
Ovarian Cancer	16	21
Brain Inflammation	12	20
Chemotherapy Induced Myelotoxicity	1	20
Diabetic Complications	11	20
High Fat Diet	10	20
Aging: Brain	5	18
Nonalcoholic fatty liver disease (NAFLD)	10	18
Melanoma	12	17
Stroke	5	17
Acetaminophen (Tylenol) Toxicity	8	15
Atherosclerosis	10	15
DNA damage	5	15
Leukemia: Acute myelogenous leukemia (AML)	5	15
Spinal Cord Injuries	9	15
Cardiovascular Diseases	11	14
Colon Cancer	12	14
Diabetes Mellitus: Type 1	7	14
HIV Infections	4	14
Hypoxia	10	14
Insulin Resistance	9	14
Chronic Kidney Disease (CKD)	3	13
Hydrogen Peroxide Induced Toxicity	11	13
Osteoarthritis	6	13
Wound Healing	7	13
Athletic Performance	2	12
Cancer Metastasis	11	12
Myocardial Infarction	7	12
Sepsis	8	12
Aging Skin	2	11
Chemotherapy-Induced Toxicity: Cyclophosphamide	7	11
Liver Fibrosis	6	11
Radiation Induced Illness	2	11
Breast Cancer: Triple Negative	8	10
Dry Eye Syndromes	1	10
Neurodegenerative Diseases	8	10
Testosterone: Too High	1	10
Aging	5	9
Chemotherapy-Induced Toxicity: Doxorubicin	6	9
Diabetic Retinopathy	5	9
Endometriosis	5	9
Hair Loss	4	9
Colitis	4	8
Diabetic Nephropathy	4	8
Glioblastoma	5	8
Ischemia	5	8
Leukemia	7	8
Prostate Cancer	8	8
Air Pollution Linked Toxicity	2	7
Atopic Dermatitis	5	7
Hypertension	4	7
Lipid Peroxidation	4	7
Lung Injury: Acute	4	7
Lung Injury: Smoke-Induced	4	7
Osteoporosis	5	7
Psoriasis	4	7
Skin Cancer	6	7
Squamous cell carcinoma	6	7
Ultraviolet Radiation Induced Damage	6	7
Alcoholic Liver Disease	3	6
Arthritis	3	6
Brain: Microglial Activation	5	6
Cardiac Hypertrophy	3	6
Cervical Cancer	6	6
Fatigue	3	6
Hypertension: Pulmonary	3	6
Inflammatory Bowel Diseases	4	6
Liver Damage	4	6
Memory Disorders: Drug-Induced	3	6
Osteosarcoma	6	6
Ovarian Failure	3	6
Dementia	3	5
Dermatitis	3	5
Erectile Dysfunction	3	5
Heart Failure	3	5
Huntington Disease	3	5
Hyperglycemia	4	5
Learning disorders	3	5
Myocardial Fibrosis	3	5
Scars	3	5
Stroke: Attenuation/Recovery	3	5
Anxiety	2	4
Autoimmune Diseases	3	4
Burns	2	4
Cardiomyopathy	2	4
Chronic Obstructive Pulmonary Disease	2	4
Diabetes: Cardiovascular Illness	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetes: Oxidative Stress	2	4
Fatigue: Excercise-Induced	2	4
Glioma	4	4
Hepatic Steatosis	2	4
Hyperlipidemia	2	4
Intestinal Ischemia	2	4
Liver Failure: Acute	2	4
Muscle Atrophy	3	4
Nasopharyngeal Cancer	4	4
Neuroblastoma	3	4
Sleep Disorders	2	4
Staphylococcus aureus infection	2	4
Stress	2	4
Acute Myeloid Leukemia	3	3
Allergic Rhinitis	2	3
Aluminum Toxicity	2	3
Cancers: Multi-Drug Resistant	2	3
Cataract	2	3
Endothelial Dysfunction	2	3
Gallbladder Cancer	2	3
Hearing Loss: Noise-Induced	2	3
Kidney Fibrosis	2	3
Liver Cirrhosis	2	3
Metabolic Diseases	2	3
Multiple Myeloma	3	3
Promyelocytic leukemia	3	3
Rheumatoid Arthritis	2	3
Tertiary butyl hydroperoxide toxicity	2	3
Thyroid Cancer	2	3
Acute T cell Leukemias	2	2
Adiponectin: Low Levels	1	2
Allergies	2	2
Anemia	1	2
Anemia: Iron Deficiency	1	2
Aneurysm: Aortic	1	2
Anti-Glomerular Basement Membrane Disease	1	2
Asthma	2	2
Attention Deficit Disorder with Hyperactivity	1	2
Brain: Oxidative Stress	1	2
Cancer: Pain	1	2
Cerebral Aneurysm	1	2
Chemobrain	1	2
Chemotherapy-Induced Kidney Damage	1	2
Chemotherapy-Induced Neurotoxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chronic Pain	1	2
Coxsackievirus Infections	2	2
Degenerative Disk Disease	2	2
Depression	1	2
Diabetes Mellitus: Type 1: Prevention	1	2
Diabetic Ulcer	1	2
Drug Toxicity: Cephaloridine	1	2
Dysmenorrhea	1	2
Encephalomyelitis	1	2
Encephalopathy	1	2
Endometrial Cancer	2	2
Epilepsy	1	2
Exercise-Induced Tissue Damage	1	2
Fatigue: Cancer-Associated	1	2
Fatty Liver	1	2
Gastric Ulcer	1	2
H1N1 Infection	1	2
Hashimoto's thyroiditis	1	2
Herbicide Toxicity	1	2
High Sugar Diet	1	2
Hypercapnia	1	2
Hypoglycemia	1	2
Influenza A	1	2
Ischemia: Myocardial	1	2
Itching	1	2
Kawasaki Disease	1	2
Keloid	1	2
Kidney Damage	1	2
Kidney Failure: Acute	1	2
Liver Damage: Drug-Induced	1	2
Low Libido	1	2
Low Testosterone	1	2
Mastitis	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mitochondrial Diseases	2	2
Morphine Tolerance/Dependence	1	2
Multiple Sclerosis	1	2
Nerve Injuries	1	2
Obstructive Nephropathy	1	2
Oral Cancer	1	2
Pain	1	2
Postoperative Recovery	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Right Ventricular Hypertrophy	1	2
Rotavirus Infections	1	2
Sciatic Nerve Crush Injury	1	2
Sciatica	1	2
Smoking: Pulmonary	1	2
Subarachnoid hemorrhage	1	2
Ulcerative Colitis	1	2
Acute lymphoblastic leukemia (ALL)	1	1
Aging: Heart	1	1
Alcohol Toxicity	1	1
Alopecia	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bladder Cancer	1	1
Bone Diseases	1	1
Brain Hypoxia	1	1
Brain Injury: Hippocampal Damage	1	1
Brain Injury: Traumatic	1	1
Central Nervous System Diseases	1	1
Cholesterol: Oxidation	1	1
Demyelinating Diseases	1	1
Dental Caries	1	1
Dyslipidemias	1	1
Endothelial Damage	1	1
Enterovirus 71	1	1
Enterovirus: Type 71	1	1
Escherichia coli Infections	1	1
Fibroma: Uterine	1	1
Fibrosarcoma	1	1
Fibrosis	1	1
Gastrointestinal Cancer	1	1
Gastrointestinal polyps	1	1
Glioblastoma Multiforme	1	1
Heart Disease: Ischemic	1	1
Hepatitis A	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Herpes Simplex Virus Type 1	1	1
Herpes Simplex Virus Type 2	1	1
Histamine: Elevated	1	1
Homocysteine: Elevated	1	1
Hyperhomocysteinemia	1	1
Immune Dysregulation: TH1 dominance	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Kidney Damage: Chemically-Induced	1	1
Kidney Failure	1	1
Lead Poisoning	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Leukemia: Multi-Drug Resistant	1	1
Leukemia: T-cell acute Lymphoblastic	1	1
Liver Disease	1	1
Liver Injury: Ischemia/reperfusion	1	1
Liver Steatosis	1	1
Medulloblastoma	1	1
Mitochondrial Dysfunction	1	1
Non-Small-Cell Lung Carcinoma	1	1
Parasitic Diseases	1	1
Pesticide Toxicity	1	1
Prion Diseases	1	1
Prostatic Hyperplasia: Benign	1	1
Pruritus	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Rectal Cancer	1	1
Retinal Diseases	1	1
Retinoblastoma	1	1
Rhinovirus Infection	1	1
Scars: Hyperplastic	1	1
Schizophrenia	1	1
Schwannoma: Vestibular	1	1
Sperm Quality: Low	1	1
Steptococcus Mutans Infections	1	1
Surgery: Anesthesiology	1	1
Tachycardia	1	1
Vascular Calcification	1	1

Name	AC	CK
Anti-Inflammatory Agents	160	303
Neuroprotective Agents	139	298
Antioxidants	114	234
Antiproliferative	135	184
Apoptotic	138	160
Anti-Apoptotic	77	139
Tumor Necrosis Factor (TNF) Alpha Inhibitor	68	113
Cardioprotective	64	107
Interleukin-1 beta downregulation	53	94
Chemotherapeutic	42	90
Anti-metastatic	53	88
Hepatoprotective	49	85
Chemoprotective Agents	27	82
NF-kappaB Inhibitor	51	81
Interleukin-6 Downregulation	41	77
Angiogenesis Inhibitors	18	63
Immunomodulatory	29	59
Chemosensitizer	20	47
Antidepressive Agents	20	39
Antineoplastic Agents	30	35
Matrix metalloproteinase-2 (MMP-2) inhibitor	24	35
Cyclooxygenase 2 Inhibitors	21	34
Vascular Endothelial Growth Factor Inhibitors	18	34
Cell cycle arrest	29	33
Nrf2 activation	21	33
Malondialdehyde Down-regulation	17	32
Matrix metalloproteinase-9 (MMP-9) inhibitor	17	29
Renoprotective	13	28
MicroRNA modulator	20	27
Chemopreventive	12	24
Hypoglycemic Agents	14	24
Anti-Fibrotic	14	23
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	12	23
Superoxide Dismutase Up-regulation	12	22
Neurogenesis	1	20
Anti-Angiogenic	7	19
Autophagy Up-regulation	13	18
Brain-derived neurotrophic factor modulator	8	16
Hypolipidemic	9	16
Bcl-2 protein down-regulation	12	14
Gastrointestinal Agents	8	14
Radioprotective	4	14
Tumor Suppressor Protein p53 Upregulation	12	14
Interleukin-18 down-regulation	6	12
Anti-HIV Agents	2	11
Cytoprotective	6	11
Heme oxygenase-1 up-regulation	6	11
Pancreato Protective Agents	5	11
HIV Protease Inhibitors	1	10
Antiviral Agents	7	9
Autophagy Inhibitors	6	9
Osteoprotective	5	8
Angiogenesis Inducing Agents	4	7
Antihypertensive Agents	4	7
Chondroprotective	2	7
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	3	7
Nitric Oxide Inhibitor	5	7
Photoprotective	6	7
Transforming growth factor beta (TGF-β) inhibitor	5	7
Wnt/β-catenin signaling pathway modulation	6	7
Analgesics	3	6
Anti-atherogenic	3	6
Antinoceceptive	3	6
Gastroprotective	3	6
Histone deacetylase inhibitor	4	6
Interleukin-4 downregulation	4	6
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	6
Anticarcinogenic Agents	3	5
Interferon Gamma Reducer	3	5
Prophylactic Agents	3	5
Prostaglandin PGE2 downregulation	1	5
SIRT1 Activator	3	5
Enzyme Inhibitors	3	4
Interleukin-8 downregulation	3	4
Neuritogenic	3	4
Radiosensitizer	3	4
Vasodilator Agents	2	4
Anti-Bacterial Agents	2	3
Heat Shock Protein Down-Regulation	2	3
Immunomodulatory: Th17 downregulation	2	3
Immunostimulatory	3	3
Insulin Sensitizers	2	3
Adiponectin upregulation	1	2
Anti-Adipogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Platelet	1	2
Anti-Ulcer Agents	1	2
Anticholesteremic Agents	1	2
Anticoagulants	1	2
Anticonvulsants	1	2
Antimicrobial	2	2
Antipruritics	1	2
Aphrodisiac	1	2
DNA Repair Up-regulation	2	2
E-cadherin down-regulation	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Female	1	2
GABA Modulators	1	2
Genoprotective	1	2
Heme oxygenase-1 inducer	2	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-22 Downregulation	1	2
Interleukin-23 Downregulation	1	2
Interleukin-5 downregulation	1	2
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	2	2
Multidrug Resistance Gene Modulators	1	2
Nitric Oxide Enhancer	1	2
Postaglandin PGE2 downregulation	1	2
Regenerative	1	2
STAT3 Inhibitor	1	2
Secretagogue	1	2
Telomerase Inhibitor	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor Regulator	2	2
Viral Hemagglutinin Inhibitor	1	2
interleukin-13 down-regulation	1	2
Acetylcholinesterase Down-Regulation	1	1
Anti-Retroviral Agents	1	1
Antiparasitic Agents	1	1
Cyclin D1 Down-Regulation	1	1
Fertility Agents: Male	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Histamine down-regulation	1	1
Insulin-Like Growth Factor Enhancer/Upregulation	1	1
Interleukin-1 alpha downregulation	1	1
Interleukin-10 upregulation	1	1
Interleukin-12 downregulation	1	1
Interleukin-2 upregulation	1	1
Osteogenic	1	1
P21 Activation	1	1
Paraptosis	1	1
Survivin Down-Regulation	1	1
Transforming growth factor beta (TGF-β) upregulation	1	1
Vascular Endothelial Growth Factor A Enhancer	1	1
Vasoprotective	1	1

Additional Keywords : Significant Treatment Outcome , Supplementation

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Enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content of skin. Jun 30, 2016

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 1994 Oct ;74(10):626-8, 648. PMID: 7842343

Article Published Date : Sep 30, 1994

Study Type : Human Study

Additional Links

Substances : Ginsenosides

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective

[+]

The combination of transcatheter arterial chemoembolization and ginsenoside Rg3 may prolong overall survival when compared with it alone.Jul 31, 2016

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Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis.Nov 30, 2020

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Pubmed Data : Adipocyte. 2020 Dec ;9(1):302-312. PMID: 32580621

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Pubmed Data : Neurosci Lett. 2010 Jul 5 ;478(2):66-71. Epub 2010 May 8. PMID: 20438804

Article Published Date : Jul 04, 2010

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Nerve Injuries

Pharmacological Actions : Neuritogenic, Neuroprotective Agents

Additional Keywords : Nerve Regeneration

[+]

20 (R) -ginsenoside Rg3 entrapped in chitosan microspheres may have a beneficial effect against fatigue.Jan 05, 2017

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Pubmed Data : Curr Drug Deliv. 2017 09 6 ;14(6):867-874. PMID: 27834150

Article Published Date : Jan 05, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Fatigue

[+]

20 (S)-ginsenoside Rg3 can inhibit the formation of gastric ulcer.Sep 30, 2019

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Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113500. Epub 2020 Oct 19. PMID: 33091499

Article Published Date : Feb 28, 2021

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, NF-kappaB Inhibitor

[+]

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

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Pubmed Data : Sci Rep. 2017 Jan 20 ;7:41144. Epub 2017 Jan 20. PMID: 28106137

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Pubmed Data : Behav Med. 2011 Apr ;37(2):42-6. PMID: 21660771

Article Published Date : Mar 31, 2011

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Ginsenosides

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Fluoxetine (trade name Prozac)

[+]

Antidepressant-like effects of ginsenosides.Dec 31, 2015

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Pubmed Data : Pharmacol Biochem Behav. 2016 Jan ;140:17-26. Epub 2015 Oct 31. PMID: 26528894

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Antiobesity effects of ginsenoside Rg1 on 3T3-L1 preadipocytes and high fat diet-induced obese mice mediated by AMPK.Jun 26, 2018

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Pubmed Data : PLoS One. 2016 ;11(1):e0146843. Epub 2016 Jan 11. PMID: 26751692

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Ginseng, Ginsenosides

Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Anti-Apoptotic, Hypoglycemic Agents

Additional Keywords : Plant Extracts

[+]

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

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Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162

Article Published Date : Apr 20, 2017

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Pubmed Data : J Ginseng Res. 2020 Jul ;44(4):619-626. Epub 2019 Jun 12. PMID: 32617042

Article Published Date : Jun 30, 2020

[+]

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2.May 31, 2014

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Pubmed Data : Tumour Biol. 2014 Jun ;35(6):5593-8. Epub 2014 Feb 21. PMID: 24557544

Article Published Date : May 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

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Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

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Pubmed Data : Curr Neurovasc Res. 2010 Mar 31. Epub 2010 Mar 31. PMID: 20353383

Article Published Date : Mar 31, 2010

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Cerebral Aneurysm, Stroke, Subarachnoid hemorrhage

[+]

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Pubmed Data : J Orthop Surg Res. 2019 Aug 14 ;14(1):259. Epub 2019 Aug 14. PMID: 31412899

Article Published Date : Aug 13, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Ischemia, Spinal Cord Injuries

Pharmacological Actions : Antioxidants

[+]

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2002 ;22(3):212-5. PMID: 12658806

Article Published Date : Dec 31, 2001

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

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Pubmed Data : Biomed Environ Sci. 2017 May ;30(5):363-372. PMID: 28549492

Article Published Date : Apr 30, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Cognitive Decline/Dysfunction, Inflammation, Oxidative Stress, Postoperative Recovery

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Ginsenoside Rb1 may be an effective treatment to prevent the secondary brain damage induced by stroke.Apr 17, 2017

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Pubmed Data : J Ethnopharmacol. 2017 Apr 18 ;202:138-146. Epub 2017 Jan 5. PMID: 28065779

Article Published Date : Apr 17, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Stroke: Attenuation/Recovery

Pharmacological Actions : Neuroprotective Agents

[+]

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Pubmed Data : J Ginseng Res. 2013 Mar ;37(1):54-63. PMID: 23717157

Article Published Date : Feb 28, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Ginsenoside Rd may be a promising anti-angiogenic drug with significant antitumor activity in human breast cancer.Jun 30, 2017

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Pubmed Data : Oncol Rep. 2017 Jul ;38(1):359-367. Epub 2017 May 19. PMID: 28534996

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:8637134. Epub 2018 Apr 22. PMID: 29849732

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Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:1091-1103. Epub 2019 Jul 10. PMID: 31372019

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Ginsenoside Rg1 ameliorates diabetic cardiomyopathy.Mar 31, 2016

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Pubmed Data : Exp Ther Med. 2017 Jul ;14(1):616-622. Epub 2017 May 25. PMID: 28672975

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Pancreato Protective Agents

[+]

Ginsenoside Rg1 can inhibit inflammatory reaction, regulate lipid metabolism, and alleviate liver injury in NAFLD.May 18, 2020

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Ginsenoside Rg1 inhibits glucagon-induced hepatic gluconeogenesis through Akt-FoxO1 interaction.Dec 31, 2016

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Pubmed Data : Int J Mol Med. 2017 Oct ;40(4):1134-1142. Epub 2017 Aug 9. PMID: 28849171

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Pubmed Data : Int J Nanomedicine. 2017 ;12:6477-6486. Epub 2017 Sep 5. PMID: 28919749

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Pubmed Data : Am J Transl Res. 2020 ;12(2):493-506. Epub 2020 Feb 15. PMID: 32194898

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Lung Injury: Smoke-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Ginsenoside Rg1 protects against non-alcoholic fatty liver disease.Oct 31, 2018

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Ginsenoside Rg1 significantly reduces liver damage in an acute liver failure model.Dec 31, 2013

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Ginsenoside Rg2 inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat-diet-induced obesity.Jun 18, 2019

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Pubmed Data : Food Funct. 2019 Jun 19 ;10(6):3603-3614. PMID: 31161181

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A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.Dec 31, 2018

Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.Dec 31, 2019

Effect of ginsenoside-Rg1 on experimental Parkinson's disease.May 31, 2021

Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

The effect of ginsenosides on depression in preclinical studies.Apr 30, 2021

The efficacy of ginsenoside Rg3 combined with first-line chemotherapy in the treatment of advanced non-small cell lung cancer. Dec 31, 2019

American ginseng has radioprotective effect on human lymphocytes at 90 minutes postirradiation.May 01, 2010

American ginseng reduces oxidative stress in patients taking the antiviral medication zidovudine without altering drug pharmacokinetics. May 01, 2008

Both hydroponically cultivated red and wild growing white ginseng have similar beneficial effects on the cognitive functions of elderly subjects.Feb 24, 2021

Daily supplementation of Korean Red Ginseng for 8 weeks significantly improved the TBUT score and subjective dry eye symptoms, as compared to placebo.Dec 31, 2014

Enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content of skin. Jun 30, 2016

Ginsenoside Rb1 treatment was effective in reducing the extent of oxidative stress and inflammation in chronic kidney disease patients.Jan 31, 2017

Ginsenoside Rd is efficacious against acute ischemic stroke.Apr 30, 2016

Ginsenoside Rg3 could be used as a new regimen to delay acquired resistance of epidermal growth factor receptor-tyrosine kinase inhibitors.Oct 24, 2016

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Ginsenoside-Rd improves outcome of acute ischaemic stroke.May 31, 2012

Ginsenoside-Rd may be of some benefit in acute ischaemic stroke.Apr 30, 2009

High-dose ginsenoside supplementation augmented the improvement of aerobic capacity by exercise training.Mar 31, 2018

Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries.Sep 30, 1994

The combination of transcatheter arterial chemoembolization and ginsenoside Rg3 may prolong overall survival when compared with it alone.Jul 31, 2016

These results suggest a potential role for ginseng in modulating salivary androgen levels.May 27, 2020

This data suggested that consumers on a Western diet should obtain better cancer prevention effects with American ginseng intake.Mar 31, 2017

Cytoprotective effects of ginsenoside Rd on apoptosis-associated cell death in the isolated human pancreatic islets.Dec 31, 2018

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Ginsenoside Rb1 shows potential for use in skin care products to protect the skin against damage by fine particles.Sep 08, 2019

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Red ginseng extract promotes the hair growth in cultured human hair follicles.Feb 28, 2015

Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis.Nov 30, 2020

Ginsenoside Rk1 alleviates LPS-induced depression-like behavior in mice by promoting BDNF and suppressing the neuroinflammatory response.Sep 30, 2020

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

"Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury."Jul 04, 2010

20 (R) -ginsenoside Rg3 entrapped in chitosan microspheres may have a beneficial effect against fatigue.Jan 05, 2017

20 (S)-ginsenoside Rg3 can inhibit the formation of gastric ulcer.Sep 30, 2019

20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.Jan 14, 2017

20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.Jan 31, 2008

20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain.Mar 31, 2009

20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Dec 31, 2018

20(s)‑ginseonside‑Rg3 modulation of AMPK/FoxO3 signaling to attenuate mitochondrial dysfunction in a dexamethasone‑injured C2C12 myotube.Apr 30, 2021

A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment.Dec 31, 2019

A Ginkgo biloba and ginsenoside Rg3 extract possesses significant protective activities against ADHD-like conditions.Feb 28, 2014

A natural compound mixture ameliorates psoriasis-like skin lesions.Dec 31, 2019

A purified dry extract of ginseng may improve cancer related fatigue via regulation of inflammatory responses and hematopoiesis.Dec 31, 2014

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

All of these experimental results suggested that Ginsenoside Rg3 may serve as a reliable drug for the treatment of patients with keloids.Feb 28, 2018

Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed mice.Jun 30, 2018

Alleviative effects of 20(R)-Rg3 on HFD/STZ-induced diabetic nephropathy.Feb 28, 2021

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

Analgesic effect and related amino acids regulation of ginsenoside Rg3 in mouse pain models.Dec 14, 2019

Anti-ageing effect of red ginseng revealed.Jun 30, 2018

Anti-hepatitic activity of ginsenoside Ro.Nov 30, 1991

Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano ginsenoside Rb1 against MSU induced gouty arthritis.Nov 30, 2020

Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol.Sep 04, 2015

Anti-obesity effects of ginsenosides in high-fat diet-fed rats.May 29, 2019

Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss.Jun 30, 2020

Antidepressant-like effect of altered Korean red ginseng in mice.Mar 31, 2011

Antidepressant-like effects of ginsenosides.Dec 31, 2015

Antiobesity effects of ginsenoside Rg1 on 3T3-L1 preadipocytes and high fat diet-induced obese mice mediated by AMPK.Jun 26, 2018

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Antitumor effect of ginsenoside Rg3 on gallbladder cancer.Oct 31, 2018

Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats.Dec 31, 2013

Berberine and ginsenoside Rb1 ameliorate depression-like behavior.May 26, 2021

Black ginseng and ginsenoside Rb1 act as potential functional anti-obesity food agents.Nov 11, 2019

Black ginseng extract counteracts streptozotocin-induced diabetes.Dec 31, 2015

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Both ginseng saponins, 20(R)- and 20(S)-ginsenoside-Rg3, possess an ability to inhibit the lung metastasis of tumor cells.Aug 31, 1995

Carbon nanotubes-loaded ginsenosides Rb3 suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer.Jun 09, 2021

Cardioprotective effects of 20(S)-ginsenoside Rh2 against doxorubicin-induced cardiotoxicity.Dec 31, 2011

Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease.Dec 24, 2012

Certain ginsenosides inhibit lung inflammatory responses.Sep 30, 2018

Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury.Nov 28, 2019

Combined ginsenoside Rg3 and transarterial embolization treatment limited metastasis and promoted survival.Dec 31, 2013

Combining Rp1 with chemotherapeutic agents could circumvent drug resistance and improve treatment efficacy.Mar 04, 2020

Ginsenosides

View the Evidence:
915 Abstracts with Ginsenosides Research