Ginsenosides

Name	AC	CK
Oxidative Stress	31	60
Lung Cancer	28	45
Alzheimer's Disease	27	41
Liver Cancer	27	40
Lipopolysaccharide-Induced Toxicity	27	39
Inflammation	25	36
Depression	15	29
Myocardial Ischemia	11	28
Cancers: All	15	27
Stroke: Ischemic	5	25
Brain Ischemia	8	23
Breast Cancer	18	22
Cerebral Ischemia	13	22
Chemically-Induced Liver Damage	11	21
Colorectal Cancer	12	21
Memory Disorders	10	20
Cancers: Drug Resistant	9	19
Diabetic Complications	9	16
Cognitive Decline/Dysfunction	8	15
Leukemia: Acute myelogenous leukemia (AML)	5	15
Ovarian Cancer	12	15
Stroke	4	15
Chemotherapy-Induced Toxicity: Cisplatin	8	14
HIV Infections	4	14
Obesity	10	14
Acetaminophen (Tylenol) Toxicity	7	13
Carcinoma: Non-Small-Cell Lung	3	13
DNA damage	4	13
Melanoma	10	13
Athletic Performance	2	12
Diabetes Mellitus: Type 2	8	12
Hypoxia	8	12
Spinal Cord Injuries	7	12
Aging Skin	2	11
Cancer Metastasis	10	11
Radiation Induced Illness	2	11
Wound Healing	6	11
Brain Inflammation	6	10
Cardiovascular Diseases	7	10
Chronic Kidney Disease (CKD)	1	10
Colon Cancer	9	10
Dry Eye Syndromes	1	10
Neurodegenerative Diseases	8	10
Osteoarthritis	4	10
Hair Loss	4	9
Aging: Brain	4	8
Chemotherapy-Induced Toxicity: Doxorubicin	5	8
Endometriosis	4	8
High Fat Diet	4	8
Myocardial Infarction	4	8
Atherosclerosis	4	7
Glioblastoma	4	7
Insulin Resistance	5	7
Leukemia	6	7
Lung Injury: Acute	4	7
Sepsis	5	7
Skin Cancer	6	7
Ultraviolet Radiation Induced Damage	6	7
Aging	3	6
Breast Cancer: Triple Negative	5	6
Cardiac Hypertrophy	3	6
Colitis	3	6
Fatigue	3	6
Hydrogen Peroxide Induced Toxicity	5	6
Hypertension	3	6
Ischemia	4	6
Liver Fibrosis	3	6
Nonalcoholic fatty liver disease (NAFLD)	3	6
Prostate Cancer	6	6
Squamous cell carcinoma	5	6
Brain: Microglial Activation	4	5
Chemotherapy-Induced Toxicity: Cyclophosphamide	3	5
Diabetes Mellitus: Type 1	3	5
Erectile Dysfunction	3	5
Learning disorders	3	5
Lipid Peroxidation	3	5
Lung Injury: Smoke-Induced	3	5
Pancreatic Cancer	3	5
Parkinson's Disease	5	5
Scars	3	5
Stroke: Attenuation/Recovery	3	5
Anxiety	2	4
Atopic Dermatitis	2	4
Burns	2	4
Cervical Cancer	4	4
Dermatitis	2	4
Diabetes: Cognitive Dysfunction	2	4
Diabetic Nephropathy	2	4
Diabetic Retinopathy	2	4
Esophageal Cancer	3	4
Fatigue: Excercise-Induced	2	4
Glioma	4	4
Heart Failure	2	4
Hyperglycemia	3	4
Hypertension: Pulmonary	2	4
Intestinal Ischemia	2	4
Liver Damage	3	4
Osteoporosis	3	4
Sleep Disorders	2	4
Staphylococcus aureus infection	2	4
Autoimmune Diseases	2	3
Dementia	2	3
Gallbladder Cancer	2	3
Gastric Cancer	3	3
Huntington Disease	2	3
Inflammatory Bowel Diseases	2	3
Liver Cirrhosis	2	3
Multiple Myeloma	3	3
Osteosarcoma	3	3
Promyelocytic leukemia	3	3
Tertiary butyl hydroperoxide toxicity	2	3
Thyroid Cancer	2	3
Acute Myeloid Leukemia	2	2
Adiponectin: Low Levels	1	2
Air Pollution Linked Toxicity	1	2
Alcoholic Liver Disease	1	2
Anemia	1	2
Aneurysm: Aortic	1	2
Attention Deficit Disorder with Hyperactivity	1	2
Brain: Oxidative Stress	1	2
Cardiomyopathy	1	2
Cerebral Aneurysm	1	2
Chemobrain	1	2
Chemotherapy-Induced Neurotoxicity	1	2
Chemotherapy-Induced Toxicity: 5-fluorouracil	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chronic Obstructive Pulmonary Disease	1	2
Coxsackievirus Infections	2	2
Depression	1	2
Diabetes: Cardiovascular Illness	1	2
Diabetes: Oxidative Stress	1	2
Drug Toxicity: Cephaloridine	1	2
Dysmenorrhea	1	2
Encephalomyelitis	1	2
Encephalopathy	1	2
Endometrial Cancer	2	2
Exercise-Induced Tissue Damage	1	2
Fatigue: Cancer-Associated	1	2
H1N1 Infection	1	2
Hashimoto's thyroiditis	1	2
Hearing Loss: Noise-Induced	1	2
Hepatic Steatosis	1	2
Herbicide Toxicity	1	2
Hypercapnia	1	2
Hyperlipidemia	1	2
Hypoglycemia	1	2
Influenza A	1	2
Ischemia: Myocardial	1	2
Itching	1	2
Keloid	1	2
Kidney Failure: Acute	1	2
Kidney Fibrosis	1	2
Liver Failure: Acute	1	2
Low Libido	1	2
Low Testosterone	1	2
Mastitis	1	2
Memory Disorders: Drug-Induced	1	2
Middle Cerebral Artery Occlusion (MCAO)	1	2
Mitochondrial Diseases	2	2
Morphine Tolerance/Dependence	1	2
Multiple Sclerosis	1	2
Muscle Atrophy	2	2
Myocardial Fibrosis	1	2
Nerve Injuries	1	2
Neuroblastoma	2	2
Obstructive Nephropathy	1	2
Ovarian Failure	1	2
Pain	1	2
Postoperative Recovery	1	2
Psoriasis	1	2
Rheumatoid Arthritis	1	2
Right Ventricular Hypertrophy	1	2
Rotavirus Infections	1	2
Sciatica	1	2
Smoking: Pulmonary	1	2
Subarachnoid hemorrhage	1	2
Acute T cell Leukemias	1	1
Acute lymphoblastic leukemia (ALL)	1	1
Alcohol Toxicity	1	1
Alopecia	1	1
Aluminum Toxicity	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Asthma	1	1
Benzo[a]pyrene-induced Toxicity	1	1
Bladder Cancer	1	1
Bone Diseases	1	1
Brain Hypoxia	1	1
Brain Injury: Hippocampal Damage	1	1
Brain Injury: Traumatic	1	1
Cancers: Multi-Drug Resistant	1	1
Central Nervous System Diseases	1	1
Cholesterol: Oxidation	1	1
Degenerative Disk Disease	1	1
Demyelinating Diseases	1	1
Dental Caries	1	1
Dyslipidemias	1	1
Endothelial Damage	1	1
Enterovirus: Type 71	1	1
Fibrosarcoma	1	1
Fibrosis	1	1
Gastrointestinal Cancer	1	1
Glioblastoma Multiforme	1	1
Hepatitis A	1	1
Hepatitis B	1	1
Hepatitis C	1	1
Histamine: Elevated	1	1
Homocysteine: Elevated	1	1
Hyperhomocysteinemia	1	1
Immune Dysregulation: TH1 dominance	1	1
Immune Dysregulation: TH1/TH2 imbalance	1	1
Lead Poisoning	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Leukemia: Multi-Drug Resistant	1	1
Liver Disease	1	1
Liver Steatosis	1	1
Medulloblastoma	1	1
Mitochondrial Dysfunction	1	1
Nasopharyngeal Cancer	1	1
Pesticide Toxicity	1	1
Prion Diseases	1	1
Prostatic Hyperplasia: Benign	1	1
Radiation-Induced Illness: Cesium-137 Exposure	1	1
Retinal Diseases	1	1
Retinoblastoma	1	1
Rhinovirus Infection	1	1
Scars: Hyperplastic	1	1
Sperm Quality: Low	1	1
Steptococcus Mutans Infections	1	1
Surgery: Anesthesiology	1	1

Name	AC	CK
Neuroprotective Agents	105	194
Anti-Inflammatory Agents	91	174
Antioxidants	84	165
Antiproliferative	95	120
Apoptotic	98	112
Anti-Apoptotic	55	90
Tumor Necrosis Factor (TNF) Alpha Inhibitor	52	85
Cardioprotective	38	72
Hepatoprotective	32	56
NF-kappaB Inhibitor	34	56
Interleukin-6 Downregulation	28	53
Interleukin-1 beta downregulation	28	49
Chemotherapeutic	25	48
Anti-metastatic	31	43
Antineoplastic Agents	26	31
Immunomodulatory	20	30
Malondialdehyde Down-regulation	16	30
Vascular Endothelial Growth Factor Inhibitors	15	30
Cyclooxygenase 2 Inhibitors	18	29
Antidepressive Agents	14	27
Matrix metalloproteinase-2 (MMP-2) inhibitor	17	27
Cell cycle arrest	21	25
Chemoprotective Agents	15	25
Chemosensitizer	16	23
Matrix metalloproteinase-9 (MMP-9) inhibitor	11	22
Nrf2 activation	15	22
Hypoglycemic Agents	12	21
Anti-Angiogenic	7	19
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	8	19
Renoprotective	7	19
Superoxide Dismutase Up-regulation	10	18
Chemopreventive	6	16
MicroRNA modulator	10	15
Angiogenesis Inhibitors	10	14
Bcl-2 protein down-regulation	12	14
Autophagy Up-regulation	9	13
Anti-Fibrotic	7	12
Anti-HIV Agents	2	11
Radioprotective	2	11
Brain-derived neurotrophic factor modulator	5	10
HIV Protease Inhibitors	1	10
Hypolipidemic	6	10
Tumor Suppressor Protein p53 Upregulation	7	8
Antiviral Agents	5	7
Chondroprotective	2	7
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	3	7
Nitric Oxide Inhibitor	5	7
Photoprotective	6	7
Angiogenesis Inducing Agents	3	6
Cytoprotective	5	6
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	6
Osteoprotective	4	6
Heme oxygenase-1 up-regulation	3	5
Histone deacetylase inhibitor	3	5
Interferon Gamma Reducer	3	5
Prophylactic Agents	3	5
Prostaglandin PGE2 downregulation	1	5
Anti-atherogenic	2	4
Antihypertensive Agents	2	4
Antinoceceptive	2	4
Autophagy Inhibitors	3	4
Enzyme Inhibitors	3	4
Neuritogenic	3	4
Pancreato Protective Agents	3	4
Radiosensitizer	3	4
Vasodilator Agents	2	4
Wnt/β-catenin signaling pathway modulation	3	4
Anticarcinogenic Agents	2	3
Heat Shock Protein Down-Regulation	2	3
Interleukin-4 downregulation	2	3
Transforming growth factor beta (TGF-β) inhibitor	2	3
Adiponectin upregulation	1	2
Analgesics	1	2
Anti-Adipogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Bacterial Agents	1	2
Anti-Platelet	1	2
Anticholesteremic Agents	1	2
Antimicrobial	2	2
Antipruritics	1	2
Aphrodisiac	1	2
DNA Repair Up-regulation	2	2
E-cadherin down-regulation	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Female	1	2
Gastroprotective	1	2
Heme oxygenase-1 inducer	2	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-8 downregulation	2	2
Multidrug Resistance Gene Modulators	1	2
Nitric Oxide Enhancer	1	2
Regenerative	1	2
SIRT1 Activator	1	2
Secretagogue	1	2
Telomerase Inhibitor	2	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor Regulator	2	2
Viral Hemagglutinin Inhibitor	1	2
Acetylcholinesterase Down-Regulation	1	1
Anti-Retroviral Agents	1	1
Cyclin D1 Down-Regulation	1	1
Fertility Agents: Male	1	1
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	1
Histamine down-regulation	1	1
Immunostimulatory	1	1
Insulin Sensitizers	1	1
Insulin-Like Growth Factor Enhancer/Upregulation	1	1
Interleukin-1 alpha downregulation	1	1
Interleukin-10 upregulation	1	1
Interleukin-12 downregulation	1	1
Interleukin-2 upregulation	1	1
Matrix Metalloproteinase-7 (MMP-7) Inhibitor	1	1
P21 Activation	1	1
Paraptosis	1	1
Survivin Down-Regulation	1	1
Vascular Endothelial Growth Factor A Enhancer	1	1

Additional Keywords : Significant Treatment Outcome , Supplementation

[+]

Enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content of skin. Jun 30, 2016

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 1994 Oct ;74(10):626-8, 648. PMID: 7842343

Article Published Date : Sep 30, 1994

Study Type : Human Study

Additional Links

Substances : Ginsenosides

Diseases : Myocardial Ischemia

Pharmacological Actions : Cardioprotective

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The combination of transcatheter arterial chemoembolization and ginsenoside Rg3 may prolong overall survival when compared with it alone.Jul 31, 2016

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Pubmed Data : Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID: 28287423

Article Published Date : Mar 09, 2017

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Ginsenosides

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Prostaglandin PGE2 downregulation

[+]

Red ginseng extract promotes the hair growth in cultured human hair follicles.Feb 28, 2015

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Pubmed Data : J Med Food. 2015 Mar ;18(3):354-62. Epub 2014 Nov 14. PMID: 25396716

All of these experimental results suggested that Ginsenoside Rg3 may serve as a reliable drug for the treatment of patients with keloids.Feb 28, 2018

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Pubmed Data : Int J Mol Med. 2018 Mar ;41(3):1487-1499. Epub 2018 Jan 4. PMID: 29328420

Article Published Date : Feb 28, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Keloid

Pharmacological Actions : Antiproliferative , Transforming growth factor beta (TGF-β) inhibitor

[+]

Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed mice.Jun 30, 2018

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Pubmed Data : J Ginseng Res. 2018 Jul ;42(3):352-355. Epub 2017 Apr 24. PMID: 29983617

Article Published Date : Jun 30, 2018

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Ginsenosides

Diseases : Cardiovascular Diseases, Diabetic Complications

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

Additional Keywords : Plant Extracts

Anti Therapeutic Actions : Western Diet

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Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

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Pubmed Data : Sci Rep. 2017 Jan 20 ;7:41144. Epub 2017 Jan 20. PMID: 28106137

Pubmed Data : Behav Med. 2011 Apr ;37(2):42-6. PMID: 21660771

Article Published Date : Mar 31, 2011

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean), Ginsenosides

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

Additional Keywords : Phytotherapy, Plant Extracts

Problem Substances : Fluoxetine (trade name Prozac)

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Antidepressant-like effects of ginsenosides.Dec 31, 2015

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Pubmed Data : Pharmacol Biochem Behav. 2016 Jan ;140:17-26. Epub 2015 Oct 31. PMID: 26528894

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Depression

Pharmacological Actions : Antidepressive Agents

[+]

Antiobesity effects of ginsenoside Rg1 on 3T3-L1 preadipocytes and high fat diet-induced obese mice mediated by AMPK.Jun 26, 2018

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Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162

Article Published Date : Apr 20, 2017

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Pubmed Data : Am J Chin Med. 2015 ;43(7):1419-38. Epub 2015 Oct 18. PMID: 26477799

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Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

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Pubmed Data : Food Funct. 2017 May 24 ;8(5):1880-1889. PMID: 28426048

Article Published Date : May 23, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Cancers: All

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Ginseng oligopeptides could be a novel natural agent for relieving exercise fatigue.Dec 12, 2016

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Pubmed Data : Nutrients. 2016 Dec 13 ;8(12). Epub 2016 Dec 13. PMID: 27983571

Article Published Date : Dec 12, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides, Panax Ginseng

Diseases : Fatigue: Excercise-Induced

Pharmacological Actions : Antioxidants

Additional Keywords : Antioxidants, Fatigue: Excercise-Induced, Ginsenosides, Panax Ginseng, Polysaccharides

[+]

Ginseng reduces neurologic damage in subarachanoid hemorrhage. Mar 31, 2010

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Pubmed Data : Curr Neurovasc Res. 2010 Mar 31. Epub 2010 Mar 31. PMID: 20353383

Article Published Date : Mar 31, 2010

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Cerebral Aneurysm, Stroke, Subarachnoid hemorrhage

[+]

Ginsenoside 20(S)-Rg3 inhibited the Warburg effect in ovarian cancer cells via H19/miR-324-5p/PKM2 pathway.Dec 31, 2017

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Pubmed Data : Cell Physiol Biochem. 2018 ;51(3):1340-1353. Epub 2018 Nov 27. PMID: 30481782

Ginsenoside compound K attenuates the development of atherosclerosis.Jul 07, 2016

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Pubmed Data : Int J Mol Sci. 2016 Jul 8 ;17(7). Epub 2016 Jul 8. PMID: 27399689

Article Published Date : Jul 07, 2016

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Atherosclerosis, Fatty Liver

Pharmacological Actions : Anti-atherogenic, Anti-Inflammatory Agents

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Ginsenoside compound K might be a potential therapeutic candidate for human liver cancer.Jun 18, 2018

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Pubmed Data : Neurosci Lett. 2011 Jan 3;487(1):70-2. Epub 2010 Oct 7. PMID: 20933058

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Pubmed Data : Vascul Pharmacol. 2015 Oct ;73:86-95. Epub 2015 Apr 22. PMID: 25912763

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Aneurysm: Aortic

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress.Mar 11, 2019

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Pubmed Data : Mol Med Rep. 2019 Mar 12. Epub 2019 Mar 12. PMID: 30864725

Article Published Date : Mar 11, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Inflammation, Intestinal Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Ginsenoside Rb1 could inhibit cardiomyocyte apoptosis induced by ischemia-reperfusion, thus alleviating ischemia-reperfusion injury.Dec 31, 2001

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2002 ;22(3):212-5. PMID: 12658806

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Pubmed Data : Exp Mol Pathol. 2018 Sep 2 ;105(3):229-235. Epub 2018 Sep 2. PMID: 30184471

Article Published Date : Sep 01, 2018

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Ischemia, Spinal Cord Injuries

Pharmacological Actions : Anti-Apoptotic

[+]

Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection.Sep 30, 2019

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Pubmed Data : Neural Regen Res. 2019 Oct ;14(10):1814-1822. PMID: 31169200

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor

[+]

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Pubmed Data : Neurobiol Dis. 2013 Jun ;54:320-8. Epub 2013 Jan 13. PMID: 23321003

Article Published Date : May 31, 2013

Study Type : Animal Study, In Vitro Study

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Substances : Ginsenosides

Diseases : Alzheimer's Disease

Pharmacological Actions : Neuroprotective Agents

[+]

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro.Dec 31, 2018

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Pubmed Data : J Ginseng Res. 2013 Mar ;37(1):54-63. PMID: 23717157

Article Published Date : Feb 28, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Ginsenoside Rd may be a promising anti-angiogenic drug with significant antitumor activity in human breast cancer.Jun 30, 2017

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Pubmed Data : Oncol Rep. 2017 Jul ;38(1):359-367. Epub 2017 May 19. PMID: 28534996

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:8637134. Epub 2018 Apr 22. PMID: 29849732

Ginsenoside Rg1 ameliorates rat myocardial ischemia-reperfusion injury.Dec 31, 2017

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Ginsenoside Rg1 can be effective antagonistic structure and function of the pancreas injury induced by D-gal. Jun 30, 2017

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Pubmed Data : Exp Ther Med. 2017 Jul ;14(1):616-622. Epub 2017 May 25. PMID: 28672975

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Pancreato Protective Agents

[+]

Ginsenoside Rg1 carries a therapeutic potential in stroke possibly through a feed-back mechanism by regulating systematic metabolic mediation.Apr 30, 2015

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Pubmed Data : Pak J Pharm Sci. 2014 Nov ;27(6 Suppl):2035-40. PMID: 25410069

Article Published Date : Oct 31, 2014

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Sciatica

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Additional Keywords : Nerve Regeneration

[+]

Ginsenoside Rg1 could exert its therapeutic effects on intestinal intestinal ischemia/reperfusion injury.Jan 01, 2016

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Pubmed Data : Int J Mol Med. 2017 Oct ;40(4):1134-1142. Epub 2017 Aug 9. PMID: 28849171

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Pubmed Data : Int J Nanomedicine. 2017 ;12:6477-6486. Epub 2017 Sep 5. PMID: 28919749

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[+]

Ginsenoside Rg3 ameliorates lipopolysaccharide-induced acute lung injury.Apr 30, 2016

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Pubmed Data : Int Immunopharmacol. 2016 May ;34:53-59. Epub 2016 Feb 24. PMID: 26921732

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginsenoside Rg3 attenuates lipopolysaccharide-induced acute lung injury.Dec 31, 2017

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Pubmed Data : Front Pharmacol. 2018 ;9:850. Epub 2018 Aug 2. PMID: 30116194

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice.Dec 31, 2011

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Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

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Pubmed Data : J Med Food. 2013 Aug ;16(8):772-6. PMID: 23957360

Article Published Date : Jul 31, 2013

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Cognitive Decline/Dysfunction, Learning disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Ginsenoside Rh2 protects against cisplatin-induced nephrotoxicity via action on caspase-mediated pathway.Feb 05, 2019

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Pubmed Data : Phytomedicine. 2019 Feb 6 ;61:152862. Epub 2019 Feb 6. PMID: 31048124

Article Published Date : Feb 05, 2019

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents

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Ginsenoside Rh2 reduces ischemic brain injury in rats.Feb 29, 2004

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Pubmed Data : Biol Pharm Bull. 2004 Mar ;27(3):433-6. PMID: 14993818

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Pubmed Data : J Ginseng Res. 2019 Jan ;43(1):10-19. Epub 2017 Jul 25. PMID: 30662289

Pubmed Data : Biol Pharm Bull. 2018 ;41(4):585-591. PMID: 29607931

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Kidney Fibrosis, Obstructive Nephropathy

Pharmacological Actions : Renoprotective

[+]

Ginsenoside-Rg3 can down-regulate the expression of VEGF and TNF-α in retina.Dec 31, 2009

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Pubmed Data : Int J Ophthalmol. 2010 ;3(3):220-3. Epub 2010 Sep 18. PMID: 22553558

Article Published Date : Dec 31, 2009

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Diabetic Retinopathy

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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GinsenosideRg3 can be employed as an early intervention and a combining therapeutic aid to reduce inflammation and hypertrophic scar formation.Dec 31, 2013

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Pubmed Data : J Ginseng Res. 2016 Jul ;40(3):285-91. Epub 2015 Oct 22. PMID: 27616905

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Pubmed Data : J Toxicol Environ Health A. 2019 Mar 27:1-13. Epub 2019 Mar 27. PMID: 30917762

Article Published Date : Mar 26, 2019

Study Type : Animal Study

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Substances : Ginseng, Ginsenosides

Diseases : Air Pollution Linked Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

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Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice.May 31, 2019

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Pubmed Data : Sci Rep. 2014 Sep 12 ;4:6352. Epub 2014 Sep 12. PMID: 25213453

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Pubmed Data : Oncotarget. 2017 Oct 13 ;8(48):83792-83801. Epub 2017 Jul 31. PMID: 29137383

Article Published Date : Oct 12, 2017

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

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Panax notoginseng saponins and two of its main components exert vasodilating effects through the NO and COX pathways.Nov 30, 2016

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Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):3998-4006. Epub 2016 Nov 9. PMID: 28101178

Article Published Date : Nov 30, 2016

Study Type : Animal Study

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Substances : Ginsenosides, Panax Notoginseng

[+]

Parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis.Dec 31, 2017

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Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 ;46(sup3):S931-S942. Epub 2018 Oct 11. PMID: 30307334

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Pubmed Data : J Korean Med Sci. 2017 Apr ;32(4):679-687. PMID: 28244297

Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice.Feb 17, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Feb 18 ;16:66. Epub 2016 Feb 18. PMID: 26887326

Article Published Date : Feb 17, 2016

Study Type : Animal Study

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Substances : Ginseng, Ginsenosides

Diseases : Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression.Mar 31, 2016

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Pubmed Data : J Ginseng Res. 2016 Apr ;40(2):151-9. Epub 2015 Jul 29. PMID: 27158236

Article Published Date : Mar 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, MicroRNA modulator

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Saponins extracted from Panax notoginseng protect against herbicide induced neurotoxicity.Feb 03, 2010

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Pubmed Data : J Ethnopharmacol. 2010 Feb 3;127(2):419-23. Epub 2009 Oct 24. PMID: 19857566

Article Published Date : Feb 03, 2010

Study Type : Animal Study

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Substances : Ginsenosides, Panax Notoginseng

Diseases :

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View the Evidence: 662 Abstracts with Ginsenosides Research

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American ginseng has radioprotective effect on human lymphocytes at 90 minutes postirradiation.May 01, 2010

American ginseng reduces oxidative stress in patients taking the antiviral medication zidovudine without altering drug pharmacokinetics. May 01, 2008

Daily supplementation of Korean Red Ginseng for 8 weeks significantly improved the TBUT score and subjective dry eye symptoms, as compared to placebo.Dec 31, 2014

Enzyme-treated red ginseng extract significantly improved eye wrinkle roughness, skin elasticity, and moisture content of skin. Jun 30, 2016

Ginsenoside Rb1 treatment was effective in reducing the extent of oxidative stress and inflammation in chronic kidney disease patients.Jan 31, 2017

Ginsenoside Rd is efficacious against acute ischemic stroke.Apr 30, 2016

Ginsenoside Rg3 could be used as a new regimen to delay acquired resistance of epidermal growth factor receptor-tyrosine kinase inhibitors.Oct 24, 2016

Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patients with acute leukemia.Dec 31, 2013

Ginsenoside-Rd improves outcome of acute ischaemic stroke.May 31, 2012

Ginsenoside-Rd may be of some benefit in acute ischaemic stroke.Apr 30, 2009

High-dose ginsenoside supplementation augmented the improvement of aerobic capacity by exercise training.Mar 31, 2018

Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries.Sep 30, 1994

The combination of transcatheter arterial chemoembolization and ginsenoside Rg3 may prolong overall survival when compared with it alone.Jul 31, 2016

This data suggested that consumers on a Western diet should obtain better cancer prevention effects with American ginseng intake.Mar 31, 2017

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Red ginseng extract promotes the hair growth in cultured human hair follicles.Feb 28, 2015

"Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury."Jul 04, 2010

20 (R) -ginsenoside Rg3 entrapped in chitosan microspheres may have a beneficial effect against fatigue.Jan 05, 2017

20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.Jan 14, 2017

20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.Jan 31, 2008

20(S)-ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain.Mar 31, 2009

20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Dec 31, 2018

A Ginkgo biloba and ginsenoside Rg3 extract possesses significant protective activities against ADHD-like conditions.Feb 28, 2014

A purified dry extract of ginseng may improve cancer related fatigue via regulation of inflammatory responses and hematopoiesis.Dec 31, 2014

Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.Feb 12, 2016

All of these experimental results suggested that Ginsenoside Rg3 may serve as a reliable drug for the treatment of patients with keloids.Feb 28, 2018

Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed mice.Jun 30, 2018

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

Anti-ageing effect of red ginseng revealed.Jun 30, 2018

Anti-hepatitic activity of ginsenoside Ro.Nov 30, 1991

Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol.Sep 04, 2015

Anti-obesity effects of ginsenosides in high-fat diet-fed rats.May 29, 2019

Antidepressant-like effect of altered Korean red ginseng in mice.Mar 31, 2011

Antidepressant-like effects of ginsenosides.Dec 31, 2015

Antiobesity effects of ginsenoside Rg1 on 3T3-L1 preadipocytes and high fat diet-induced obese mice mediated by AMPK.Jun 26, 2018

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Antitumor effect of ginsenoside Rg3 on gallbladder cancer.Oct 31, 2018

Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats.Dec 31, 2013

Black ginseng extract counteracts streptozotocin-induced diabetes.Dec 31, 2015

Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.Apr 20, 2017

Both ginseng saponins, 20(R)- and 20(S)-ginsenoside-Rg3, possess an ability to inhibit the lung metastasis of tumor cells.Aug 31, 1995

Cardioprotective effects of 20(S)-ginsenoside Rh2 against doxorubicin-induced cardiotoxicity.Dec 31, 2011

Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease.Dec 24, 2012

Certain ginsenosides inhibit lung inflammatory responses.Sep 30, 2018

Combined ginsenoside Rg3 and transarterial embolization treatment limited metastasis and promoted survival.Dec 31, 2013

Components of Astragalus and Panax notoginseng could strengthen the protective effects on cerebral ischemia injury.Dec 31, 2014

Compound K protects pancreatic islet cells against apoptosisJun 26, 2014

Cultured wild ginseng root extract fermented by P. pentosaceus contains the distinctive ginsenosides Rg5/Rk1, which may ameliorate memory impairment.May 19, 2019

Effect of ginsenoside pre-treatment on 5-hydroxytryptamine system in rats with myocardial infarction and depression.Aug 31, 2016

Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice.Jun 30, 2006

Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats.Mar 29, 2017

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2.May 31, 2014

Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

Evaluation of chemopreventive action of Ginsenoside Rp1.Dec 31, 2005

Explosively puffed ginseng ameliorates ionizing radiation-induced injury of colon.Apr 30, 2019

findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.Dec 31, 2011

Flavored black ginseng exhibited antitumor activity via improving immune function and inducing apoptosis.May 23, 2017

Ginseng oligopeptides could be a novel natural agent for relieving exercise fatigue.Dec 12, 2016

Ginseng reduces neurologic damage in subarachanoid hemorrhage. Mar 31, 2010

Ginsenoside 20(S)-Rg3 inhibited the Warburg effect in ovarian cancer cells via H19/miR-324-5p/PKM2 pathway.Dec 31, 2017

Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.Dec 04, 2015

Ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo.Oct 04, 2014

Ginsenoside 25-OCH3-PPD could be used to curve the development of hepatic fibrosis.Jul 10, 2018

Ginsenoside ameliorated diabetic cognitive decline.Jun 09, 2018

Ginsenoside compound K attenuates cognitive deficits in vascular dementia.Feb 28, 2019

Ginsenoside compound K attenuates the development of atherosclerosis.Jul 07, 2016

Ginsenoside compound K might be a potential therapeutic candidate for human liver cancer.Jun 18, 2018

Ginsenoside compound-K inhibits the activity of B cells through inducing IgD-B cell receptor endocytosis in mice with collagen-induced arthritis.Jun 03, 2019

Ginsenoside F2 may be a novel therapeutic approach for treating skin inflammation.Sep 29, 2016

Ginsenoside F2 reduces hair loss by controlling apoptosis.Dec 31, 2013

Ginsenoside has an anti-neuroinflammation effect in a rat model of Alzheimer disease.Jan 03, 2011

Ginsenosides

View the Evidence:
662 Abstracts with Ginsenosides Research