Hesperidin

Name	AC	CK
Hemorrhoids	7	61
Oxidative Stress	11	24
Obesity	2	12
Chronic Venous Insufficency	2	11
Liver Cancer	7	11
Venous Ulcer	2	11
Aphthous Ulcer	1	10
Bladder Degeneration	1	10
Chronic Pelvic Pain Syndrome	1	10
Diabetes Mellitus: Type 2: Prevention	1	10
Epistaxis	1	10
Hematuria	1	10
Leg Ulcer	1	10
Nose Bleed	1	10
Pelvic Inflammatory Disease	1	10
Postoperative Recovery	1	10
Ultraviolet Radiation Induced Damage	2	10
Vericose Veins: Bladder	1	10
Brain Inflammation	4	8
Depression	4	8
Inflammation	5	8
Lipid Peroxidation	4	8
Radiation Induced Illness	5	8
Aluminum Toxicity	3	6
Alzheimer's Disease	3	6
Diabetic Complications	3	6
Gastric Ulcer	3	6
Hypertension	4	6
Osteoporosis	3	6
Atherosclerosis	3	5
Chemotherapy and Radiation Toxicity	3	5
Rheumatoid Arthritis	3	5
Alcohol Toxicity	2	4
Brain: Oxidative Stress	2	4
Cancers: All	3	4
Chemically-Induced Liver Damage	2	4
Chemotherapy-Induced Toxicity: Cisplatin	2	4
DNA damage	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Ulcer	2	4
Ehrlich carcinoma	2	4
Ischemia	2	4
Myocardial Ischemia	2	4
Oral Cancer	2	4
Sepsis	2	4
Tongue Cancer	2	4
Breast Cancer	2	3
Colitis	2	3
Diabetic Retinopathy	3	3
Influenza A	2	3
Kidney Cancer	2	3
Lipopolysaccharide-Induced Toxicity	2	3
Osteoarthritis	2	3
Acute Respiratory Distress Syndrome	1	2
Advanced Glycation End products (AGE)	1	2
Allergic Rhinitis	1	2
Arterial Hardening: Elasticity	1	2
Arthritis: Rheumatoid	1	2
Athletic Performance	1	2
Brain Injury: Traumatic	1	2
Cancers: Drug Resistant	1	2
Cardiac Hypertrophy	1	2
Cardiomyopathy	1	2
Chemotherapy-Induced Toxicity: Cyclophosphamide	1	2
Cognitive Decline/Dysfunction	1	2
Colon Cancer	1	2
Diabetes Mellitus: Type 2	1	2
Drug Toxicity: Methotrexate	1	2
Endothelial Dysfunction	1	2
Exercise-Induced Tissue Damage	1	2
Fatty Liver	1	2
Gastrointestinal Inflammation	1	2
Gastrointestinal Surgical Procedures	1	2
Gout	1	2
Hepatic Steatosis	1	2
Hydrogen Peroxide Induced Toxicity	1	2
Hyperglycemia	1	2
Hyperuricemia	1	2
Iron Overload	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Liver Cirrhosis	1	2
Liver Fibrosis	1	2
Lung Cancer	1	2
Lung Cancer: Prevention	1	2
Lymphatic Diseases	1	2
Lymphatic Stasis	1	2
Lymphedema	1	2
Memory Disorders	1	2
Multiple Sclerosis	1	2
Neurodegenerative Diseases	2	2
Neuropathic Pain	1	2
Osteosarcoma	1	2
Otitis media	1	2
Pancreatic Cancer	1	2
Pancreatitis	1	2
Parkinson's Disease	1	2
Periodontitis	1	2
Pesticide Toxicity	1	2
Petroleum Exposure And Toxicity	1	2
Pleurisy	1	2
Proctitis	1	2
Psoriasis	1	2
Squamous cell carcinoma	1	2
Subarachnoid hemorrhage	1	2
Sugar (Sucrose) Toxicity	1	2
Ulcerative Colitis	1	2
Ulcers	1	2
Vaccine-induced Toxicity	1	2
Wound Healing	1	2
Acute Myeloid Leukemia	1	1
Adiponectin: Low Levels	1	1
Aging	1	1
Allergic Airway Diseases	1	1
Amyotrophic lateral sclerosis (ALS)	1	1
Cartilage Diseases	1	1
Gallbladder Cancer	1	1
Glioma	1	1
HIV Infections	1	1
Hypoglycemia	1	1
Influenza	1	1
Insulin Resistance	1	1
Liver Cancer: Prevention	1	1
Neuroblastoma	1	1
Neutropenia	1	1
Neutropenia: Chemotherapy Induced	1	1
Non-Small-Cell Lung Carcinoma	1	1
Promyelocytic leukemia	1	1
Radiation	1	1
Skin Cancer	1	1

Name	AC	CK
Anti-Inflammatory Agents	38	87
Antioxidants	37	77
Tumor Necrosis Factor (TNF) Alpha Inhibitor	17	31
Neuroprotective Agents	13	25
Interleukin-1 beta downregulation	11	22
Interleukin-6 Downregulation	11	20
Anti-Apoptotic	8	17
Chemopreventive	10	16
Anticarcinogenic Agents	9	15
Radioprotective	9	15
Hepatoprotective	7	14
NF-kappaB Inhibitor	8	14
Antihypertensive Agents	2	12
Antiproliferative	7	11
Analgesics	1	10
Photoprotective	2	10
Renoprotective	5	10
Apoptotic	8	9
Nrf2 activation	5	9
Anti-Ulcer Agents	4	8
Antidepressive Agents	4	8
Chemoprotective Agents	4	8
Cyclooxygenase 2 Inhibitors	4	7
Hypolipidemic	4	7
Cardioprotective	3	6
Osteoprotective	3	6
Superoxide Dismutase Up-regulation	3	6
Gastroprotective	3	5
Hypoglycemic Agents	3	5
Interleukin-4 downregulation	3	5
Nitric Oxide Inhibitor	3	5
Brain-derived neurotrophic factor modulator	2	4
Immunomodulatory	2	4
Malondialdehyde Down-regulation	2	4
Anti-metastatic	2	3
Cell cycle arrest	2	3
Chemosensitizer	2	3
Heme oxygenase-1 up-regulation	2	3
Interleukin-10 downregulation	2	3
Angiogenesis Inducing Agents	1	2
Anti-Angiogenic	1	2
Anti-Fibrotic	1	2
Anti-Glycation Agents	1	2
Antiviral Agents	2	2
Autophagy Inhibitors	1	2
Catalase Up-Regulation	1	2
Chemotherapeutic	2	2
Dermatologic Agents	1	2
Gastrointestinal Agents	1	2
Genoprotective	1	2
Glutathione Upregulation	1	2
Heat Shock Protein Down-Regulation	1	2
Lymphagogue	1	2
Matrix metalloproteinase-9 (MMP-9) inhibitor	2	2
Neurogenesis	1	2
Postaglandin PGE2 downregulation	1	2
Prophylactic Agents	1	2
Vascular Endothelial Growth Factor C Inhibitor	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
Vascular Endothelial Growth Factor Regulator	1	2
Vasodilator Agents	1	2
Wnt/β-catenin signaling pathway modulation	1	2
Acetylcholinesterase Inhibitor	1	1
Alpha-glucosidase inhibitor	1	1
Bcl-2 protein down-regulation	1	1
C-Jun N-Terminal Kinases (JNK) Modulator	1	1
Chondroprotective	1	1
Expectorants	1	1
Extracellular Signal-Regulated Kinases Modulator	1	1
Inhibitor of Nuclear Factor Kappa-B Kinase (IKK)	1	1
Interferon Gamma Reducer	1	1
Matrix Metalloproteinase-13 (MMP-13) Inhibitor	1	1
Matrix metalloproteinase-3 (MMP-3) inhibitor	1	1
MicroRNA modulator	1	1
NF-kappa-B-inducing kinase (NIK) modulator	1	1
Neurominidase Inhibitor	1	1
P21 Activation	1	1
P38 Mitogen-Activated Protein Kinase Modulator	1	1
Prostaglandin PGE2 downregulation	1	1

[+]

A combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat.Dec 31, 2015

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Pubmed Data : Nutr J. 2016 ;15(1):6. Epub 2016 Jan 19. PMID: 26786000

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Pubmed Data : Wien Klin Wochenschr. 2005 Aug;117(15-16):558-60. PMID: 16158207

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Pubmed Data : Acta Chir Belg. 2004 Nov-Dec;104(6):715-8. PMID: 15663281

Article Published Date : Nov 01, 2004

Study Type : Animal Study

Additional Links

Substances : Diosmin , Hesperidin

Diseases : Gastrointestinal Surgical Procedures

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A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

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Pubmed Data : Tumour Biol. 2015 Jun 23. Epub 2015 Jun 23. PMID: 26099723

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Pubmed Data : J Med Phys. 2016 Jul-Sep;41(3):182-91. PMID: 27651565

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Pubmed Data : Exp Toxicol Pathol. 2017 Jan 26. Epub 2017 Jan 26. PMID: 28132802

Article Published Date : Jan 25, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Diabetes Mellitus: Type 1, Osteoporosis

Pharmacological Actions : Osteoprotective , Prophylactic Agents

Additional Keywords : Risk Reduction

[+]

Hesperidin could be used to enhance wound healing in chronic diabetic foot ulcers.Dec 31, 2017

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Pubmed Data : Life Sci. 2017 Jul 25. Epub 2017 Jul 25. PMID: 28754618

Article Published Date : Jul 24, 2017

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation

[+]

Hesperidin has a protective effect on sodium arsenite-induced nephrotoxicity and hepatotoxicity.Jul 30, 2018

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Pubmed Data : Biol Trace Elem Res. 2018 Jul 31. Epub 2018 Jul 31. PMID: 30066062

Hesperidin provided antioxidant and chemoprotective activities against the toxicity of DMBA in breast, liver and kidney tissues.Sep 30, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:718-724. Epub 2016 Jul 29. PMID: 27470573

Article Published Date : Sep 30, 2016

Study Type : Animal Study

Additional Links

Substances : Hesperidin, Nuts

Diseases : Breast Cancer, Kidney Cancer, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive

[+]

Hesperidin reduces the effects of ischemia/reperfusion injury damage.Sep 30, 2016

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Pubmed Data : : Planta Med. 2009 Mar;75(4):295-301. Epub 2009 Feb 13. PMID: 19219759

Article Published Date : Mar 01, 2009

Study Type : Animal Study

Additional Links

Substances : Hesperidin

[+]

Additional Keywords : Drug: Omeprazole, Plant Extracts

[+]

Short-term pre-treatment with hesperidin protects against myocardial I/R injury by suppressing myocardial apoptosis.Dec 31, 2015

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Pubmed Data : Cell Physiol Biochem. 2016 ;39(5):1850-1862. Epub 2016 Oct 17. PMID: 27744432

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective

[+]

Standardized extracts of lycopene and hesperidin together can be cheap and very effective herbal alternative for the treatment of ulcers.Mar 31, 2015

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Pubmed Data : J Biochem Mol Toxicol. 2019 Feb 19:e22305. Epub 2019 Feb 19. PMID: 30779474

Article Published Date : Feb 18, 2019

Study Type : Animal Study

Additional Links

Substances : Hesperidin

Diseases : Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants

[+]

The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.Jun 30, 2018

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Additional Keywords : Dose Response, Drug: Cytarabine, Natural Substance/Drug Synergy

[+]

Hesperidin and THSG might be potential lead compound to design inhibitors of mutant SOD1 for ALS therapy.Dec 31, 2013

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Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:156276. Epub 2014 May 18. PMID: 24963318

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Substances : Hesperidin

Diseases : Amyotrophic lateral sclerosis (ALS)

[+]

Hesperidin appears to be a potent chemopreventive agent against renal carcinogenesis possibly by virtue of its antioxidant properties.Nov 30, 2015

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Pubmed Data : Exp Mol Pathol. 2015 Dec ;99(3):641-53. Epub 2015 Nov 10. PMID: 26551080

Article Published Date : Nov 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Kidney Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Apoptotic, Chemopreventive

Additional Keywords : Dose Response

[+]

Hesperidin can be considered as a potential anticancerous compound for the treatment of gall bladder carcinoma.Sep 27, 2018

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Pubmed Data : Nutr Cancer. 2018 Sep 28:1-12. Epub 2018 Sep 28. PMID: 30265812

Article Published Date : Sep 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

[+]

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2008 Feb;54(1):95-8. PMID: 18388414

Article Published Date : Feb 01, 2008

Additional Links

Substances : Hesperidin

Diseases : Hypertension

[+]

Hesperidin has potent antioxidant and neuroprotective effects.Apr 01, 1985

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Pubmed Data : Gastroenterology. 1985 Apr;88(4):901-7. PMID: 16964766

Article Published Date : Apr 01, 1985

Additional Links

Substances : Hesperidin

Diseases : Neurodegenerative Diseases

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View the Evidence: 151 Abstracts with Hesperidin Research

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A combination of 500-mg G-hesperidin and 75-mg caffeine for 12 weeks significantly reduced abdominal fat.Dec 31, 2015

A combination of diosmin and hesperidin (Daflon) has been shown to be effective in alleviating (variable degree) haemorrhoidal symptoms and improving the proctoscopic appearance of haemorrhoids.Dec 01, 2004

A combination of diosmin and hesperidin (Daflon) has been shown to be safe and effective in the treatment of all hemorrhoidal symptoms.Dec 01, 2002

A combination of diosmin and hesperidin significantly reduces bleeding in patients with acute internal hemorrhoids. Jun 01, 2005

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 1. Jun 01, 2006

A micronized purified flavonoid fraction (MPFF) consisting of diosmin and hesperidin significantly improves the symptoms of patients with acute hemorrhoids. - Article 2. Jul 01, 2000

Daflon, a form of micronized diosmin and hesperidin, improves symptoms of chronic venous insufficiency. Nov 01, 2001

Daflon, a form of micronized diosmin and hesperidin, improves the healing of venous leg ulcers. Sep 01, 2005

Daflon, a form of micronized diosmin and hesperidin, restores pelvic circulation and relieves pelvic symptomatology in women with pelvic pain. Jan 01, 2007

Flavonoids (hesperidin) have therapeutic value in the treatment of bleeding bladder varices.Oct 01, 2003

Hesperidin has therapeutic value in the treatment of recurrent aphthous stomatitis. Apr 01, 2006

Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD.Jun 30, 2019

The flavonoids hesperidin and diosmin reduce bleeding and pain after stapled hemorrhoidopexy. Aug 01, 2005

The flavonoids hesperidin and diosmin strengthen capillaries in patients with epistaxis. Mar 01, 1993

These results suggest that hesperidin may have antihypertensive and anti-inflammatory effects in type 2 diabetes.Feb 21, 2018

Hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis.Jan 14, 2016

Hesperidin treatment effectively protected HaCaT keratinocytes from these UVA radiation-induced skin injuries.Nov 30, 2016

A combination of diosmin and hesperidin (Daflon) improves lymphatic flow indicating its therapeutic role in conditions like perivascular edema. Sep 01, 1995

A combination of diosmin and hesperidin (Detralex) attenuates adjuvant-induced arthritis in rats treated with methotrexate. May 01, 2008

A combination of diosmin and hesperidin is effective in the prevention of intestinal reperfusion injury in an experimental model in rats. Nov 01, 2004

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury.Dec 31, 2015

A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.Aug 11, 2015

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Bee venom plus hesperidin particularly seemed to be the most potent in improving rheumatoid arthritis in Wistar rats.May 31, 2018

Beta-Cryptoxanthin and Hesperidin are potential cancer chemopreventive agents against tongue, colon, and lung cancers. Jan 01, 2012

Both hesperidin and thymol were effective in suppressing allergic symptoms and inflammation in the treatment of allergic rhinitis.Nov 27, 2018

Combined treatment with naringenin and hesperetin might be a promising anti-cancer strategy for pancreatic cancers.Nov 19, 2018

Curcumin, beta-carontein and hesperidin prevent chemically-induced oral cancer.Sep 01, 1994

Diosmin and hesperidin may have protective effects against radiation-induced acute proctitis.Mar 31, 2011

Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes.Dec 31, 2018

Egyptian sweet orange hesperidin ameliorates the cytotoxic effect of doxorubicin while enhancing its anti-tumor effect.Mar 31, 2018

Hesperetin attenuates testicular damage in diabetic rats.Sep 30, 2018

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model.Feb 11, 2019

Hesperetin may be a potential novel therapeutic candidate for protection against ventilator-induced acute lung injury.Dec 14, 2015

Hesperetin possesses a potential chemopreventive activity against Benzo[a]pyrene induced lung cancer.Dec 04, 2015

Hesperetin prevents bone resorption by inhibiting RANKL-induced osteoclastogenesis.Dec 31, 2017

Hesperetin protects against cisplatin-induced ototoxicity in a animal model.May 31, 2016

Hesperetin treatment leads to a decrease in oxidative stress, and associated histological damage.Dec 31, 2015

Hesperidin a flavanoglycone protects against gamma-irradiation induced liver damage and oxidative stress in rats.Jun 10, 2008

Hesperidin a positive immunomodulatory effect in a clinically relevant model of Acute Respiratory Distress Syndrome.Apr 24, 2007

Hesperidin accelerates the gastric healing process of acetic acid-induced ulcer.May 12, 2019

Hesperidin administration could have significant therapeutic value for the prevention and clinical treatment of psoriasis.Feb 14, 2019

Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats.Apr 24, 2019

Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress.Oct 18, 2018

Hesperidin and capsaicin prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats.Oct 09, 2018

Hesperidin and chrysin alleviated the renal injury induced by colistin via anti-oxidant and anti-inflammatory activities.Nov 30, 2018

Hesperidin and quercetin may play an effective role in regulating insulin metabolism metabolism in diabetes.Mar 31, 2018

Hesperidin and silibinin exert neuroprotective effects against aluminum chloride induced cognitive impairment and neurochemical changes.May 27, 2015

Hesperidin as adjuvant therapy with DOX would enhance the therapeutic efficacy and alleviate the resistance to DOX in treatment of solid tumors.Jun 22, 2015

Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance.Jul 01, 2009

Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury.Nov 14, 2018

Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy.Jun 27, 2017

Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in a model of Parkinson's disease.Jan 04, 2018

Hesperidin can be used as a cardioprotective agent in chronically ethanol-induced cardiotoxicity.Oct 27, 2018

Hesperidin can perform a radioprotection action.Jun 30, 2016

Hesperidin can prevent hydrogen peroxide-induced chondrocytes injury.Dec 16, 2018

Hesperidin can protect against intestinal inflammation.Feb 27, 2019

Hesperidin could alleviate H1N1-induced impairment of pulmonary function by inhibiting cytokine production in pulmonary microvascular endothelial cells.Apr 05, 2018

Hesperidin could be a potential therapeutic agent in the treatment of oxidative stress associated neurodegenerative diseases.Feb 14, 2016

Hesperidin could be considered to be a beneficial treatment for preventing diabetic osteoporosis in growing age.Jan 25, 2017

Hesperidin could be used to enhance wound healing in chronic diabetic foot ulcers.Dec 31, 2017

Hesperidin could reduce the incidence and severity of Multiple sclerosis.Nov 25, 2016

Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models.Oct 31, 2018

Hesperidin has a prophylactic effect against hepatocarcinogenesis.Jul 24, 2017

Hesperidin has a protective effect on sodium arsenite-induced nephrotoxicity and hepatotoxicity.Jul 30, 2018

Hesperidin has protective effect against sepsis-induced lung injury.Jan 03, 2019

Hesperidin has radioprotective properties in the liver of mice.May 11, 2011

Hesperidin has radioprotective properties. May 31, 2009

Hesperidin has therapeutic effects in the formation and maintenance of bone mass and strength.Mar 01, 2008

Hesperidin may be a good candidate for modulating oral inflammatory diseases.Sep 06, 2018

Hesperidin may be a promising modulator in preventing renal cancer.Aug 10, 2018

Hesperidin may be further evaluated as a promising molecule for the alleviation of cardiac hypertrophy.Jan 07, 2019

Hesperidin

View the Evidence:
151 Abstracts with Hesperidin Research