Isothiocyanates

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228 Diseases Researched for Isothiocyanates
NameACCKFocus
Oxidative Stress3385Locked
Prostate Cancer3149Locked
Breast Cancer2942Locked
Inflammation1640Locked
Lung Cancer1540Locked
Cancers: All2438Locked
DNA damage1031Locked
Autism Spectrum Disorders230Locked
Breast Cancer: Triple Negative 929Locked
Colon Cancer1429Locked
Pancreatic Cancer1729Locked
Lung Cancer: Prevention321Locked
Melanoma720Locked
Bladder Cancer718Locked
Liver Cancer1518Locked
Helicobacter Pylori Infection517Locked
Diabetes Mellitus: Type 2616Locked
Cancer Metastasis1115Locked
Insulin Resistance314Locked
Prostate Cancer: Prevention414Locked
Smoking214Locked
Alzheimer's Disease613Locked
Cancers: Drug Resistant813Locked
Autism212Locked
Diesel Exhaust Particle Toxicity 312Locked
Glutathione Deficiency 312Locked
Air Pollution Linked Toxicity211Locked
Lipopolysaccharide-Induced Toxicity811Locked
Skin Diseases211Locked
Anemia: Sickle Cell 110Locked
Asthma110Locked
Bladder Degeneration110Locked
COPD110Locked
Cognitive Decline/Dysfunction510Locked
Cystic Fibrosis110Locked
Fatty Liver110Locked
Gastritis110Locked
High Cholesterol110Locked
Hyperinsulinism110Locked
Lung Diseases110Locked
Prostate: PSA Doubling110Locked
Pulmonary Fibrosis110Locked
Radical Prostatectomy110Locked
Respiratory Diseases110Locked
Schizophrenia110Locked
Glioblastoma79Locked
Endothelial Dysfunction38Locked
Ovarian Cancer78Locked
Cerebral Ischemia47Locked
Chemotherapy-Induced Toxicity: Cisplatin47Locked
Colorectal Cancer57Locked
Oral Cancer57Locked
Adenomatous Polyposis Coli36Locked
Chemically-Induced Liver Damage46Locked
Liver Cancer: Prevention26Locked
Benzo[a]pyrene-induced Toxicity 35Locked
Brain Inflammation 45Locked
Cancer Stem Cells55Locked
Chemotherapy-Induced Toxicity: Doxorubicin45Locked
Endothelial Damage15Locked
Hypoxia45Locked
Immune Disorders: Low Immune Function35Locked
Leukemia55Locked
Neurodegenerative Diseases45Locked
Obesity35Locked
Acetaminophen (Tylenol) Toxicity 24Locked
Aflatoxicosis34Locked
Aspirin-Induced Toxicity 24Locked
Brain Injury: Traumatic24Locked
Brain: Microglial Activation24Locked
Cadmium Poisoning 34Locked
Carcinoma: Non-Small-Cell Lung34Locked
Depression24Locked
Diabetic Complications24Locked
Diabetic Nephropathy34Locked
Gastric Cancer34Locked
Intestinal Polyps24Locked
NSAID-induced toxicity 24Locked
Nicotine/Tobacco Toxicity 14Locked
Organ Transplantation: Pancreatic Islet Cells24Locked
Skin Cancer34Locked
Skin Cancer: Prevention24Locked
Spinal Cord Injuries24Locked
Traumatic Brain Injury24Locked
Advanced Glycation End products (AGE)23Locked
Aging Skin23Locked
Bacterial Infections and Mycoses23Locked
Blood-Brain-Barrier Disorders23Locked
Brain Cancer33Locked
Brain Damage23Locked
Cardiovascular Diseases33Locked
Cervical Cancer33Locked
Chemotherapy-Induced Toxicity23Locked
Diabetes Mellitus: Type 1: Prevention23Locked
Drug-Induced Toxicity: Indomethacin23Locked
Gastric Ulcer23Locked
Glioma23Locked
Head and Neck Cancer33Locked
Hydrogen Peroxide Induced Toxicity33Locked
Intestinal Diseases23Locked
Liver Damage: Aflatoxin-Induced23Locked
Low Disorders: Low TH123Locked
Melanoma: Metastatic23Locked
Multiple Myeloma23Locked
Myocardial Ischemia23Locked
Nasopharyngeal Cancer23Locked
Osteosarcoma23Locked
Parkinson's Disease33Locked
Petroleum Exposure And Toxicity23Locked
Polycyclic aromatic hydrocarbon (PAH) toxicity23Locked
Promyelocytic leukemia 33Locked
Rheumatoid Arthritis23Locked
Skin Diseases: Photo-Aging23Locked
Aging12Locked
Amphetamine Addiction/Withdrawal12Locked
Anxiety Disorders12Locked
Atherosclerosis12Locked
Bladder Dysfunction 12Locked
Bladder Outlet Obstruction12Locked
Brain Edema12Locked
Brain Hypoxia22Locked
Breast Cancer: Metastatic22Locked
Cachexia: Cancer12Locked
Cancers: Multi-Drug Resistant12Locked
Carbon Monoxide Poisoning 12Locked
Chemical Exposure12Locked
Chemical Weapon Agent Injury 12Locked
Depressive Disorder12Locked
Diabetes Mellitus: Type 112Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetes: Memory Problems12Locked
Duchenne's Muscular Dystrophy12Locked
Ehrlich carcinoma12Locked
Epstein-Barr Virus Infections12Locked
Gastrointestinal Cancer12Locked
Glioblastoma Multiforme12Locked
Gout12Locked
Gram-Negative Bacterial Infections12Locked
Gram-Positive Bacterial Infections12Locked
Heart Failure12Locked
High Fat Diet12Locked
Hypertension12Locked
Hypoglycemia22Locked
Immune Dysregulation: TH1/TH2 imbalance12Locked
Intoxication12Locked
Ischemia12Locked
Kidney Diseases12Locked
Lead Poisoning12Locked
Light Sensitivity12Locked
Liver Disease12Locked
Low Immune Function: Natural Killer Cells12Locked
Malathion Toxicity12Locked
Mercury Poisoning12Locked
Muscle Damage: Exercise-Induced12Locked
Muscle Fatigue12Locked
Muscle Soreness12Locked
Myocardial Infarction12Locked
Nephropathy12Locked
Neurologic Disorders12Locked
Neuropathic Pain12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Organ Transplantation12Locked
Respiratory Syncytial Virus Infections12Locked
Respiratory Tract Infections12Locked
Salivary Gland Adenoid Cystic Carcinoma.22Locked
Salivary Gland Diseases22Locked
Schwannoma: Vestibular12Locked
Seizures12Locked
Serotonin Disorders12Locked
Stroke12Locked
Stroke: Recovery12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Tumors22Locked
Ulcerative Colitis12Locked
Acute T cell Leukemias11Locked
Allergies11Locked
Androgen-Induced Diseases11Locked
Aortic Plaques11Locked
Arsenic Poisoning11Locked
Bone Destructive Diseases: Over-Active Osteoclasts11Locked
Brain Injury: Hippocampal Damage11Locked
Breast Cancer: HER-2 Overexpressed11Locked
Breast Cancer: Prevention11Locked
Cardiac Hypertrophy11Locked
Cardiovascular Disease: Prevention11Locked
Cholangiocarcinoma11Locked
Cholesterol: LDL/HDL ratio11Locked
Colon Cancer: Prevention11Locked
Colorectal Tumors11Locked
Dopamine Deficiency11Locked
Drug-Induced Toxicity 11Locked
Dystrophic retinal detachment (DRD)11Locked
Encephalomyelitis11Locked
Escherichia coli Infections11Locked
Excitotoxicity 11Locked
Fibrosis11Locked
Fungal Infection11Locked
Gastrointestinal Diseases11Locked
HDL: Low11Locked
HIV Infections11Locked
Hepatitis C11Locked
Heterocyclic Aromatic Amine Induced Toxicity11Locked
Hyperglycemia11Locked
IgE-Mediated Hypersensitivity11Locked
Keloid11Locked
Kidney Damage11Locked
Leukemia: Acute promyelocytic leukemia 11Locked
Macular Degeneration11Locked
Malignant Melanoma11Locked
Medulloblastoma11Locked
Melanism11Locked
Microcystis aeruginosa11Locked
Mitochondrial Diseases11Locked
Multiple Sclerosis11Locked
Neuroblastoma11Locked
Oral Cancer: Prevention11Locked
Osteoporosis: Over-active Osteoclasts11Locked
Pancreatic Cancer Stem Cell11Locked
Pesticide Toxicity 11Locked
Prediabetes11Locked
Pseudomonas aeruginosa11Locked
Restenosis11Locked
Retinal Diseases11Locked
Sciatic Nerve Crush Injury11Locked
Stomach Cancer11Locked
Striatonigral Degeneration: Autosomal Dominant11Locked
Sunburn11Locked
Ultraviolet Radiation Induced Damage11Locked
103 Pharmacological Actions Researched for Isothiocyanates
NameACCKFocus
Antioxidants74176Locked
Anticarcinogenic Agents85161Locked
Apoptotic102146Locked
Chemopreventive63130Locked
Anti-Inflammatory Agents48124Locked
Antiproliferative 69116Locked
Nrf2 activation4089Locked
Neuroprotective Agents3374Locked
Phase II Detoxification Enzyme Inducer1440Locked
Cell cycle arrest3136Locked
Anti-metastatic2332Locked
Cytoprotective531Locked
Chemotherapeutic2129Locked
NF-kappaB Inhibitor2528Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1728Locked
Antineoplastic Agents1924Locked
Interleukin-1 beta downregulation1523Locked
Hepatoprotective821Locked
Interleukin-6 Downregulation1521Locked
Cyclooxygenase 2 Inhibitors1420Locked
Chemosensitizer1519Locked
Histone deacetylase inhibitor1019Locked
Enzyme Inhibitors817Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor1015Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor1014Locked
MicroRNA modulator1314Locked
Genoprotective312Locked
Glutathione Upregulation 312Locked
Hypolipidemic212Locked
Tumor Suppressor Protein p53 Upregulation611Locked
Anti-Allergic Agents110Locked
Cardioprotective810Locked
Insulin Down-Regulation110Locked
NF-E2-Related Factor-2 (Nrf2) Modulator89Locked
Anti-Apoptotic47Locked
Anti-Bacterial Agents56Locked
Immunomodulatory46Locked
Renoprotective46Locked
Anti-Angiogenic45Locked
Bcl-2 protein down-regulation55Locked
Heme oxygenase-1 up-regulation55Locked
Superoxide Dismutase Up-regulation15Locked
Antidepressive Agents24Locked
Antiviral Agents34Locked
Radioprotective24Locked
Wnt/β-catenin signaling pathway modulation44Locked
Anti-Ulcer Agents23Locked
Chemoprotective Agents23Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor23Locked
Prostaglandin PGE2 downregulation23Locked
Survivin Down-Regulation33Locked
Telomerase Inhibitor33Locked
Vascular Endothelial Growth Factor Inhibitors23Locked
Angiogenesis Inhibitors12Locked
Anti-Anxiety Agents12Locked
Anti-Cachexic Agents12Locked
Anti-Fibrotic22Locked
Anticonvulsants12Locked
Antinoceceptive 12Locked
Autophagy Inhibitors12Locked
Autophagy Up-regulation22Locked
Cytotoxic22Locked
Detoxifier22Locked
Epidermal growth factor receptor (EGFR) inhibitor12Locked
Gastroprotective12Locked
Heat Shock Protein Inducer12Locked
Hypotensive12Locked
Immunomodulatory: Th17 downregulation12Locked
Interleukin-17 downregulation12Locked
Interleukin-18 down-regulation12Locked
Interleukin-2 upregulation12Locked
Leptin Down-Regulation12Locked
Nitric Oxide Inhibitor12Locked
Phase I Detoxification Enzyme Inducer12Locked
Proteasome Inhibitors22Locked
Serotonergic12Locked
Anti-Glycation Agents11Locked
Anti-Proliferative11Locked
Antifungal Agents11Locked
Antimitotic Agents11Locked
Antimutagenic Agents11Locked
Appetite Suppresant11Locked
Beta-Defensin-2 Up-Regulation11Locked
Caspase-3 Activation11Locked
Cell Differentiation Inducer11Locked
DNA Repair Up-regulation11Locked
Estrogen Receptor Modulators11Locked
Hypoglycemic Agents11Locked
Interferon Gamma Reducer11Locked
Interleukin-10 upregulation11Locked
Interleukin-4 upregulation11Locked
Interleukin-8 downregulation11Locked
Neuritogenic11Locked
P21 Activation11Locked
Postaglandin PGE2 downregulation 11Locked
Quinone Reductase-Inducer11Locked
Radiopharmaceuticals11Locked
Radiosensitizer11Locked
Vascular Cell Adhesion Molecule-1 Inhibitor 11Locked
Vascular Endothelial Growth Factor Regulator11Locked
Wnt/β-catenin pathway down-regulation11Locked
anti-inflammatory11Locked
interleukin-13 down-regulation11Locked
Related Topics

The Following are Sub-Topics of Isothiocyanates

View the Evidence:
585 Abstracts with Isothiocyanates Research

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973
Article Published Date : Oct 17, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Epigenetic Modification In Cancer
[+]

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Pubmed Data : Int J Food Sci Nutr. 2012 Nov ;63(7):767-71. Epub 2012 Apr 26. PMID: 22537070
Article Published Date : Oct 31, 2012
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Hyperinsulinism, Insulin Resistance
Pharmacological Actions : Antioxidants, Insulin Down-Regulation
[+]

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID: 27071063
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Anemia: Sickle Cell
Additional Keywords : Gene Expression Regulation
[+]

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID: 22045030
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Air Pollution Linked Toxicity, DNA damage
Additional Keywords : Isothiocyanates
[+]

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Broccoli, Broccoli Sprouts, Sprouts, Sulforaphane
Diseases : Gastritis, Helicobacter Pylori Infection
[+]

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID: 20423504
Article Published Date : Dec 31, 2009
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Lung Cancer, Lung Cancer: Prevention, Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Risk Reduction
[+]

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Pubmed Data : Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID: 25466142
Article Published Date : Apr 14, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.Apr 04, 2017

Pubmed Data : J Nutr. 2017 Apr 5. Epub 2017 Apr 5. PMID: 28381528
Article Published Date : Apr 04, 2017
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2015 May 12. Epub 2015 May 12. PMID: 25968598
Article Published Date : May 11, 2015
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate: PSA Doubling, Radical Prostatectomy
Additional Keywords : Recurrence Risk, Significant Treatment Outcome
[+]

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Pubmed Data : Cancer Prev Res (Phila). 2018 Apr 24. Epub 2018 Apr 24. PMID: 29691233
Article Published Date : Apr 23, 2018
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive
[+]

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):918-26. Epub 2015 Apr 7. PMID: 25851421
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli, Isothiocyanates
Diseases : High Cholesterol
Pharmacological Actions : Hypolipidemic
[+]

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Autism. 2018 ;9:35. Epub 2018 May 30. PMID: 29854372
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism Spectrum Disorders
Pharmacological Actions : Antioxidants
[+]

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.Jan 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 06 13 ;7(1):3398. Epub 2017 Jun 13. PMID: 28611391
Article Published Date : Jan 12, 2017
Study Type : Human Study
Additional Links
Substances : Broccoli, Isothiocyanates
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Chondroprotective
[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID: 18950181
Article Published Date : Nov 26, 2008
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Raw versus Cooked
[+]

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;55(1):53-62. PMID: 16965241
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.Apr 28, 2020

Pubmed Data : Psychiatry Clin Neurosci. 2020 Apr 29. Epub 2020 Apr 29. PMID: 32347624
Article Published Date : Apr 28, 2020
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism Spectrum Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126
Article Published Date : Jul 03, 2019
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Air Pollution Linked Toxicity, Benzene Toxicity
Pharmacological Actions : Antioxidant Effects, Detoxifier
Additional Keywords : Airborne Pollution, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Dose Response, Environmental Pollutant, Environmental Pollution
Problem Substances : Airborne Pollution, Benzene
[+]

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Glob Adv Health Med. 2017 ;6:2164957X17735826. Epub 2017 Oct 26. PMID: 29147630
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism
[+]

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Chemopreventive, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer, Bladder Degeneration, DNA damage
Pharmacological Actions : Chemopreventive, Genoprotective
[+]

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID: 26369337
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Asthma, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID: 17416783
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Skin Diseases
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Pubmed Data : Food Funct. 2014 Jan ;5(1):35-41. PMID: 24287881
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diesel Exhaust Particle Toxicity
Pharmacological Actions : Anti-Allergic Agents
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Proc Natl Acad Sci U S A. 2014 Oct 28 ;111(43):15550-5. Epub 2014 Oct 13. PMID: 25313065
Article Published Date : Oct 27, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Isothiocyanates, Sulforaphane
Diseases : Autism Spectrum Disorders, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cytoprotective, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Risk Factors
[+]

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539
Article Published Date : Apr 29, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Schizophrenia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653
Article Published Date : Nov 20, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Fatty Liver
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

Pubmed Data : Nutr Cancer. 2000;38(2):168-78. PMID: 11525594
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Raw versus Cooked
[+]

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0140963. Epub 2015 Nov 2. PMID: 26524341
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Additional Keywords : Food Vs. Supplement, Increased Bioavailability, Plant Extracts
[+]

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID: 25522265
Article Published Date : Feb 28, 2015
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
Additional Keywords : Absorption, Bioavailability, Dietary Modification
[+]

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neuropsychiatry. 2018 May ;3(4):214-222. Epub 2018 Apr 17. PMID: 29888232
Article Published Date : May 01, 2018
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Psychiatric Disorders
Pharmacological Actions : Glutathione Upregulation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, psychiatric disorders
[+]

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID: 24742583
Article Published Date : Mar 29, 2014
Study Type : Human In Vitro
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Dietary Concentrations
[+]

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5263985. Epub 2018 Dec 17. PMID: 30647811
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Catechin , Sulforaphane
Diseases : Oxidative Stress
Pharmacological Actions : Regenerative
Additional Keywords : Isothiocyanates
[+]

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Pubmed Data : Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID: 29969714
Article Published Date : Jan 20, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidant Effects, Nrf2 activation
Additional Keywords : Antioxidants, Broccoli, Broccoli Sprouts, Cruciferous Vegetables
[+]

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2018 08 15 ;353:23-30. Epub 2018 Jun 6. PMID: 29885333
Article Published Date : Jan 15, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Cadmium Poisoning , Cancers
Pharmacological Actions : Anticarcinogenic Agents, Antioxidant, Antioxidant Effects, Apoptotic, Autophagy Up-regulation, NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Pubmed Data : Cells Tissues Organs. 2018 ;206(1-2):46-53. Epub 2018 Jul 24. PMID: 30041241
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Anti-Angiogenic, Anti-cancer, Anti-metastatic, Anti-Proliferative, Cyclooxygenase 2 Inhibitors, Hypoxia-inducible factor-1 (HIF-1) inhibitor, Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables
[+]

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4125297. Epub 2018 Nov 18. PMID: 30581529
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Leukemia
Pharmacological Actions : Antioxidant, Antioxidant Effects, Antiproliferative , NADPH Oxidase Inhibitors
Additional Keywords : Broccoli, Broccoli Sprouts, Isothiocyanates
[+]

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID: 30595796
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Nrf2 activation
Additional Keywords : calorie restriction, High Sugar Diet, Isothiocyanates
[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID: 30338040
Article Published Date : Sep 21, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
Additional Keywords : Anti-cancer
[+]

Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.Dec 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID: 30524952
Article Published Date : Dec 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Estrogen
Additional Keywords : Estrogen Positive Breast Cancer, Folate, Methylation
[+]

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID: 31137828
Article Published Date : May 27, 2019
Study Type : Human In Vitro
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Insulin Disorders, Insulin Resistance
Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers
Additional Keywords : Broccoli, Cruciferous Vegetables, glucose control, Glucose Uptake Enhancement
[+]

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Pubmed Data : Food Funct. 2015 May 26. Epub 2015 May 26. PMID: 26008201
Article Published Date : May 25, 2015
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Endothelial Damage, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
[+]

Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.Jul 08, 2019

Pubmed Data : Biochim Biophys Acta Mol Basis Dis. 2019 Jul 8 ;1865(10):2586-2594. Epub 2019 Jul 8. PMID: 31295528
Article Published Date : Jul 08, 2019
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Fetal Alcoholism
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Alcohol, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Mesenchymal Stem Cells, Pregnancy And Fetal Growth
[+]

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:165-171. Epub 2018 May 15. PMID: 29772437
Article Published Date : Aug 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Pubmed Data : Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348. Epub 2016 Aug 16. PMID: 27636860
Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Cytoprotective, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Selective Cytotoxicity
[+]

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.Mar 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2018 Mar 12 ;15(1):75. Epub 2018 Mar 12. PMID: 29530050
Article Published Date : Mar 11, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro. Aug 01, 2019

Pubmed Data : Int J Food Sci Nutr. 2019 Aug ;70(5):570-578. Epub 2019 Jan 9. PMID: 30624124
Article Published Date : Aug 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Gastric Cancer, Gastric Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Anti-cancer
[+]

Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.Jun 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Jun 4 ;10(6). Epub 2018 Jun 4. PMID: 29866995
Article Published Date : Jun 04, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.Feb 01, 2019

Pubmed Data : J Reprod Immunol. 2019 Feb ;131:44-49. Epub 2018 Dec 29. PMID: 30641297
Article Published Date : Feb 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Anti-Inflammatory Agents, Immune Enhancing Properties
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Pregnancy
[+]

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625
Article Published Date : Dec 01, 2005
Study Type : Human In Vitro
Additional Links
Substances : Broccoli, Sulforaphane, Watercress
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

Pubmed Data : Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID: 30226534
Article Published Date : Nov 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Female, Ovarian Cancer
Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, HER-2 oncoprotein down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Drug Synergy, Isothiocyanates
[+]

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Erucin, Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Chemopreventive
[+]

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."May 28, 2012

Pubmed Data : Mol Carcinog. 2012 May 29. Epub 2012 May 29. PMID: 22641235
Article Published Date : May 28, 2012
Study Type : Insect Study
Additional Links
Substances : Sulforaphane
Diseases : Epstein-Barr Virus Infections, Nasopharyngeal Cancer
[+]

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

Pubmed Data : J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID: 22853439
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2012 ;2012:821936. Epub 2012 Sep 23. PMID: 23050040
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetic Nephropathy
[+]

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

Pubmed Data : Psychopharmacology (Berl). 2012 Jul ;222(1):37-45. Epub 2011 Dec 27. PMID: 22200890
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Amphetamine Addiction/Withdrawal, Brain: Microglial Activation, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

Pubmed Data : Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID: 23201461
Article Published Date : Nov 29, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemical Weapon Agent Injury , Skin Cancer: Prevention
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865
Article Published Date : Sep 01, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492
Article Published Date : Aug 22, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity
[+]

A dietary isothiocyanate-enriched moringa seed extract improves glucose tolerance in a high-fat-diet model.Jul 31, 2018

Pubmed Data : J Funct Foods. 2018 Aug ;47:376-385. Epub 2018 Jun 9. PMID: 30930963
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents
[+]

Allyl isothiocyanate ameliorates angiogenesis and inflammation in dextran sulfate sodium-induced acute colitis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e102975. Epub 2014 Jul 22. PMID: 25051185
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Colitis, Inflammation
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor A Inhibitor
[+]

Allyl isothiocyanate ameliorates dextran sodium sulfate-induced colitis.Jul 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jul 12 ;19(7). Epub 2018 Jul 12. PMID: 30002285
Article Published Date : Jul 11, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Colitis, Inflammatory Bowel Diseases, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Gastrointestinal Agents
[+]

Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease.Sep 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2019 Sep 14 ;25(34):5120-5133. PMID: 31558861
Article Published Date : Sep 13, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hypolipidemic
[+]

Allyl isothiocyanate ameliorates obesity by inhibiting galectin-12.Dec 31, 2017

Pubmed Data : Mol Nutr Food Res. 2018 03 ;62(6):e1700616. Epub 2018 Mar 12. PMID: 29345776
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents
[+]

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury.Jan 31, 2019

Pubmed Data : Mol Biol Rep. 2019 Feb ;46(1):241-250. Epub 2018 Nov 8. PMID: 30406889
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Brain: Oxidative Stress, Inflammation, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Allyl isothiocyanate possesses antidiabetic, antioxidant, and anti-inflammatory activities in high-fat diet/streptozotocin-induced type 2 diabetes mellitus.Jun 30, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Jul ;33(7):e22328. Epub 2019 Mar 30. PMID: 30927557
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation
[+]

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation.Jun 05, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Med Sci. 2018 Jun 6 ;80(6):893-897. Epub 2018 Apr 17. PMID: 29669958
Article Published Date : Jun 05, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.Sep 30, 2003

Pubmed Data : Carcinogenesis. 2003 Oct ;24(10):1665-70. Epub 2003 Aug 1. PMID: 12896904
Article Published Date : Sep 30, 2003
Study Type : Animal Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

Anti-estrogenic and anti-cell proliferative effect of allyl isothiocyanate in chemoprevention of chemically induced mammary carcinogenesis.Mar 19, 2019

Pubmed Data : Pathol Oncol Res. 2019 Mar 20. Epub 2019 Mar 20. PMID: 30895454
Article Published Date : Mar 19, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Estrogenic, Chemopreventive
[+]

Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Sci. 2020 Nov ;21(6):e91. PMID: 33263238
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1674-83. Epub 2011 Mar 3. PMID: 21376772
Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Catechin , Ellagic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
Problem Substances : Benzo(a)pyrene
[+]

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID: 29797311
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Stroke
Pharmacological Actions : Platelet aggregation inhibitor: collagen-induced aggregation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables
[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Isothiocyanates, Stilbenes
[+]

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cells.Oct 31, 2018

Pubmed Data : Environ Toxicol. 2018 Nov ;33(11):1097-1104. Epub 2018 Jul 4. PMID: 29972272
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antiproliferative
[+]

Benzyl isothiocyanate inhibits prostate cancer development.Jan 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 02 22 ;17(2):264. Epub 2016 Feb 22. PMID: 26907265
Article Published Date : Jan 21, 2016
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest, Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer.Jan 09, 2017

Pubmed Data : Sci Rep. 2017 Jan 10 ;7:40070. Epub 2017 Jan 10. PMID: 28071670
Article Published Date : Jan 09, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1808-1818. Epub 2019 Jun 18. PMID: 31257529
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression.Dec 31, 2014

Pubmed Data : Mol Carcinog. 2015 Jan ;54(1):72-82. Epub 2014 Apr 11. PMID: 24729546
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer, High Fat Diet
Pharmacological Actions : Antiproliferative
Additional Keywords : Tumor Microenvironment
[+]

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 19144376
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Petroleum Exposure And Toxicity, Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Pubmed Data : J Nutr Biochem. 2016 Oct 11 ;39:134-144. Epub 2016 Aug 11. PMID: 27833054
Article Published Date : Oct 10, 2016
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Depression, Depressive Disorder, Inflammation
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
[+]

Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.Jun 06, 2018

Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925
Article Published Date : Jun 06, 2018
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Malondialdehyde Down-regulation, Nrf2 activation, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.Oct 01, 2009

Pubmed Data : Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID: 19669099
Article Published Date : Oct 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation. Oct 30, 2007

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID: 17956979
Article Published Date : Oct 30, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Aging Skin
[+]

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue. Jul 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID: 17347138
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
[+]

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Pubmed Data : J Food Sci. 2010 Aug 1;75(6):H190-9. PMID: 20722931
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brussel sprouts, Sulforaphane
Diseases : Chemical Exposure, Intoxication
Pharmacological Actions : Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.May 25, 2015

Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579
Article Published Date : May 25, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
[+]

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Fig, Sulforaphane, Vitamin E
Diseases : Cadmium Poisoning , Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
Problem Substances : Cadmium
[+]

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Pubmed Data : Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28089829
Article Published Date : Jan 11, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Capsaicin, Piceatannol , Resveratrol, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance Synergy
[+]

Consumption of sulforaphane-enriched broccoli soup may inhibit bacterial growth in the stomach and upper small intestine.Jul 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2020 Jul 10. Epub 2020 Jul 10. PMID: 32651764
Article Published Date : Jul 09, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Escherichia coli Infections
Pharmacological Actions : Antimicrobial
[+]

Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2016 ;7(6):e2246. Epub 2016 Jun 2. PMID: 27253410
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Curcumin and phenethyl isothiocyanate have a synergistic inhibitory effect on the growth of human prostate xenografts. Jul 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 16423986
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Curcumin and phenyethylisothiocyanate inhibite mouse prostate cancer. Sep 01, 2008

Pubmed Data : Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 18437538
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID: 26107664
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Cognitive Decline/Dysfunction, Neurologic Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Hematol. 2019 09 ;77:51-60.e1. Epub 2019 Aug 9. PMID: 31404577
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Damage, Sickle Cell Anemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
[+]

Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions.Apr 29, 2007

Pubmed Data : Eur J Pharmacol. 2007 Apr 30 ;561(1-3):172-81. Epub 2007 Jan 27. PMID: 17346695
Article Published Date : Apr 29, 2007
Study Type : Animal Study
Additional Links
Substances : Horseradish, Isothiocyanates
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Gastroprotective
[+]

Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.Feb 15, 2017

Pubmed Data : Diabetes. 2017 Feb 16. Epub 2017 Feb 16. PMID: 28209760
Article Published Date : Feb 15, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation
[+]

Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity.Jul 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Jul 25 ;254:102-8. Epub 2016 May 27. PMID: 27241356
Article Published Date : Jul 24, 2016
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0184709. Epub 2017 Sep 18. PMID: 28922365
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Isothiocyanates exhibit anti-myeloma activity. Aug 01, 2011

Pubmed Data : Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID: 21712538
Article Published Date : Aug 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Isothiocyanate, Sulforaphane
Diseases : Multiple Myeloma
Pharmacological Actions : Apoptotic
[+]

Naringin in combination with isothiocyanates as liposomal formulations potentiates the anti-inflammatory activity.Nov 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2020 Nov 3 ;5(43):28319-28332. Epub 2020 Oct 26. PMID: 33163815
Article Published Date : Nov 02, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Isothiocyanates
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID: 29436058
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Ginseng, Resveratrol, Sulforaphane
Diseases : Chronic Pain, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Inflammatory Diet, Risk Factors
[+]

Oncogenic c-Myc is a target of sulforaphane to prevent and eliminate the onset of human prostate cancer.Mar 14, 2016

Pubmed Data : J Cell Biochem. 2016 Mar 15. Epub 2016 Mar 15. PMID: 26990292
Article Published Date : Mar 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.Sep 15, 2005

Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336
Article Published Date : Sep 15, 2005
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Phenethyl isothiocyanate, Sulforaphane
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity , Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.Aug 01, 2019

Pubmed Data : Cell Oncol (Dordr). 2019 Aug 2. Epub 2019 Aug 2. PMID: 31376137
Article Published Date : Aug 01, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Breast Cancer, Ovarian Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Phenethyl isothiocyanate inhibits in vivo growth of xenograft tumors of human glioblastoma cells.Sep 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 10 ;23(9). Epub 2018 Sep 10. PMID: 30201893
Article Published Date : Sep 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative
[+]

Phenethyl isothiocyanate may act as a promising anticancer agent either alone or in combination with doxorubicin through apoptotic cell death induction.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2018 ;17(4):1328-1338. PMID: 30568691
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Ehrlich carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Phenethyl isothiocyanate protects against high fat/cholesterol diet-induced obesity and atherosclerosis.Nov 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Nov 27 ;12(12). Epub 2020 Nov 27. PMID: 33261070
Article Published Date : Nov 26, 2020
Study Type : Animal Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Phenethyl isothiocyanate treatment suppressed the proliferation of ALDH1 expressing cancer stem cells.Feb 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 27 ;20(5). Epub 2019 Feb 27. PMID: 30818757
Article Published Date : Feb 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Pre-treatment with sulforaphane or thymoquinone can reduce acetylsalicylic acid-induced gastric ulcers.Jun 14, 2016

Pubmed Data : J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID: 27363643
Article Published Date : Jun 14, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane, Thymoquinone
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective
[+]

Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.Apr 12, 2018

Pubmed Data : Carcinogenesis. 2018 Apr 13. Epub 2018 Apr 13. PMID: 29668854
Article Published Date : Apr 12, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
[+]

Protective effects of sulforaphane and aerobic exercise on acute alcoholic hepatic injury in mice.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Nov ;27(11):3145-3149. Epub 2020 Jul 14. PMID: 33100876
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alcoholic Liver Disease
Therapeutic Actions : Exercise: Aerobic
Pharmacological Actions : Hepatoprotective
[+]

Protective effects of sulforaphane in experimental vascular cognitive impairment.Dec 31, 2017

Pubmed Data : J Cereb Blood Flow Metab. 2018 Jan 1:271678X18764083. Epub 2018 Jan 1. PMID: 29533123
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents, Nrf2 activation
[+]

Protective effects of sulforaphane on exercise-induced organ damage via inducing antioxidant defense responses.Feb 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Feb 4 ;9(2). Epub 2020 Feb 4. PMID: 32033211
Article Published Date : Feb 03, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Muscle Damage: Exercise-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabolism. 2020 Jan ;102:154002. Epub 2019 Nov 9. PMID: 31706979
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiomyopathy, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.Jan 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Differ. 2016 10 ;23(10):1615-27. Epub 2016 Jun 3. PMID: 27258787
Article Published Date : Jan 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

Sufloraphane has a protective effect on preserved pancreas and may have a potential clinical implication to improve hemodynamically unstable pancreas donor condition.Jan 01, 2004

Pubmed Data : Ann Transplant. 2004;9(3):68-71. PMID: 15759553
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions : Antioxidants
[+]

Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals. Oct 01, 2006

Pubmed Data : Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID: 16600309
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Lung Cancer, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.Jan 05, 2017

Pubmed Data : J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID: 28059653
Article Published Date : Jan 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Antiproliferative, Apoptotic, Cancer Stem Cells, glioblastoma (GBM), Sulforaphane
[+]

Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS.Jul 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AMB Express. 2020 Jul 3 ;10(1):119. Epub 2020 Jul 3. PMID: 32621086
Article Published Date : Jul 02, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.Feb 18, 2019

Pubmed Data : Behav Brain Res. 2019 Feb 19 ;364:213-224. Epub 2019 Feb 19. PMID: 30790585
Article Published Date : Feb 18, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Autism
Pharmacological Actions : Antioxidants, Immunomodulatory: Th17 downregulation, Nrf2 activation
[+]

Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice.Jun 30, 2019

Pubmed Data : Biol Reprod. 2019 Jul 1 ;101(1):223-234. PMID: 31004475
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : High Fat Diet, Infertility: Male
Pharmacological Actions : Fertility Agents: Male
[+]

Sulforaphane ameliorates okadaic acid induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway.Oct 02, 2015

Pubmed Data : Mol Neurobiol. 2015 Oct 3. Epub 2015 Oct 3. PMID: 26433376
Article Published Date : Oct 02, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Inflammation , Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane ameliorates some features of clinical diabetic complications particularly the lipid profile and insulin responsiveness.Apr 19, 2016

Pubmed Data : Food Funct. 2016 Apr 20 ;7(4):2060-5. PMID: 27025193
Article Published Date : Apr 19, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetic Complications, Insulin Resistance
Pharmacological Actions : Hypolipidemic
[+]

Sulforaphane and curcumin protect against malathion toxicity. Jun 30, 2012

Pubmed Data : Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID: 22957429
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin, Sulforaphane
Diseases : Malathion Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sulforaphane and dibenzoylmethane alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers.Oct 15, 2007

Pubmed Data : Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926
Article Published Date : Oct 15, 2007
Study Type : Animal Study
Additional Links
Substances : Dibenzoylmethane (DBM), Sulforaphane
Diseases : Adenomatous Polyposis Coli, Gastrointestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive
[+]

Sulforaphane and NAC (N-acetyl-L-cysteine) upregulate T(H)1 immunity in aging.May 01, 2008

Pubmed Data : J Allergy Clin Immunol. 2008 May;121(5):1255-1261.e7. Epub 2008 Mar 5. PMID: 18325578
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Sulforaphane
Diseases : Aging, Immune Disorders: Low Immune Function, Immune Dysregulation: TH1/TH2 imbalance, Low Disorders: Low TH1
Pharmacological Actions : Antioxidants, Immunomodulatory
[+]

Sulforaphane and vitamin E could ameliorate cognitive decline and oxidative damage in pups with lead exposure at lactation from maternal milk.Nov 30, 2017

Pubmed Data : J Trace Elem Med Biol. 2017 Dec ;44:88-92. Epub 2017 Jun 15. PMID: 28965607
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane, Vitamin E
Diseases : Cognitive Decline/Dysfunction, Lead Poisoning
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Lead
[+]

Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose.Mar 17, 2020

Pubmed Data : Neurochem Int. 2020 Mar 18:104728. Epub 2020 Mar 18. PMID: 32199985
Article Published Date : Mar 17, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice.Oct 03, 2017

Pubmed Data : J Nutr Biochem. 2017 Oct 4 ;51:69-79. Epub 2017 Oct 4. PMID: 29096318
Article Published Date : Oct 03, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.Feb 05, 2017

Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666
Article Published Date : Feb 05, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Helicobacter Pylori Infection, NSAID-induced toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Aspirin , Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sulforaphane could inhibit inflammation in human umbilical vein ECs exposed to advanced glycation end products.Apr 20, 2016

Pubmed Data : Nutr Metab Cardiovasc Dis. 2016 Apr 21. Epub 2016 Apr 21. PMID: 27212619
Article Published Date : Apr 20, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Sulforaphane could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat.Aug 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 Aug 9 ;39(3):901-907. Epub 2016 Aug 9. PMID: 27497670
Article Published Date : Aug 08, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes: Memory Problems, Diabetic Complications
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.Aug 01, 2018

Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151
Article Published Date : Aug 01, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379
Article Published Date : Feb 01, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Dyslipidemias, Fatty Liver, Insulin Resistance
Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents, Insulin Sensitizers
Additional Keywords : Isothiocyanates
Problem Substances : Fructose
[+]

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562
Article Published Date : Nov 15, 2005
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Edema, Traumatic Brain Injury
[+]

Sulforaphane enhances leptin sensitivity and prevents weigh gain in diet-induced obese mice.Sep 15, 2018

Pubmed Data : Eur J Pharmacol. 2018 Sep 15 ;835:108-114. Epub 2018 Jul 29. PMID: 30063917
Article Published Date : Sep 15, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Obesity
Additional Keywords : Body Mass Index (BMI), Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates, leptin
[+]

Sulforaphane enhances lipid metabolism through improved mitochondrial function by Nrf-2 and PGC-1a-dependent mechanisms.Jan 01, 2019

Pubmed Data : Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID: 30578708
Article Published Date : Jan 01, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Mitochondrial Dysfunction
Pharmacological Actions : Lipolytic, Nrf2 activation, Peroxisome Proliferators
Additional Keywords : Mitochondria, mitochondria dysfunction, Mitochondrial Biogenesis
[+]

Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer. Aug 29, 2011

Pubmed Data : Nutr Cancer. 2011 Aug 29. Epub 2011 Aug 29. PMID: 21875325
Article Published Date : Aug 29, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug Synergy
[+]

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.Nov 01, 2008

Pubmed Data : Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID: 18980980
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma.Oct 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Oct 4 ;7(1):12651. Epub 2017 Oct 4. PMID: 28978924
Article Published Date : Oct 03, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Chemopreventive, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Sulforaphane exhibits antiproliferative, apoptotic, anti-inflammatory, and anti-angiogenic properties and ameliorates a rat model of endometriosis.Apr 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID: 31217757
Article Published Date : Apr 01, 2019
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Endometriosis
Pharmacological Actions : Anti-Angiogenic, Anti Inflammatory, Antiproliferative , Apoptotic, Interferon Gamma Reducer, Interleukin-10 downregulation, PI3K-AKT inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Cytokines, Inflammation, Interleukin-6 Downregulation, women's health
[+]

Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.Dec 01, 2006

Pubmed Data : Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 16952200
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Sulforaphane has anticonvulsant properties and could improve mitochondrial function.Sep 13, 2015

Pubmed Data : J Neurochem. 2015 Sep 14. Epub 2015 Sep 14. PMID: 26365487
Article Published Date : Sep 13, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Nrf2 activation
[+]

Sulforaphane has antidepressant and anxiolytic like activities in stressed mice model of depression.Dec 21, 2015

Pubmed Data : Behav Brain Res. 2015 Dec 22 ;301:55-62. Epub 2015 Dec 22. PMID: 26721468
Article Published Date : Dec 21, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane has both anti-nociceptive and anti-inflammatory actions.Jan 31, 2017

Pubmed Data : Inflammopharmacology. 2017 Feb ;25(1):99-106. Epub 2017 Jan 4. PMID: 28054242
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Sulforaphane has immunomodulatory properties.Aug 01, 2007

Pubmed Data : Phytomedicine. 2007 Aug;14(7-8):538-45. Epub 2006 Nov 3. PMID: 17084602
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
[+]

Sulforaphane has potential as a therapeutic agent to protect T2DM patients from cognitive deficiencies.Apr 19, 2018

Pubmed Data : Neuroscience. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29684505
Article Published Date : Apr 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane has preventive action in oxidative stress-mediated liver injury associated with acetaminophen (APAP)-induced toxicity.May 31, 2015

Pubmed Data : Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID: 25818464
Article Published Date : May 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Sulforaphane has significant protective effects against oxidative stress and could ameliorate bladder dysfunction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:7598294. Epub 2016 Jun 28. PMID: 27433291
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Dysfunction , Bladder Outlet Obstruction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane has the potential to prevent neuronal disorders by enhancing Brain-derived Neurotrophic Factor (BDNF) and its TrkB signaling pathways. Jan 01, 2017

Pubmed Data : Mol Nutr Food Res. 2017 02 ;61(2). Epub 2016 Nov 30. PMID: 27735126
Article Published Date : Jan 01, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Brain-derived neurotrophic factor modulator
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Epigenetic Modification, Isothiocyanates
[+]

Sulforaphane improved cardiac function and remodelling by inhibiting oxidative stress and inflammation.Mar 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Mar 12 ;24:1473-1483. Epub 2018 Mar 12. PMID: 29527002
Article Published Date : Mar 11, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Sulforaphane improved islet function in vivo, indicating that combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation.Feb 01, 2010

Pubmed Data : Muscle Nerve. 2010 Feb;41(2):185-90. PMID: 16504726
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Organ Transplantation, Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions : Anticarcinogenic Agents
[+]

Sulforaphane improves cognitive function administered following traumatic brain injury.Aug 28, 2009

Pubmed Data : Neurosci Lett. 2009 Aug 28;460(2):103-7. Epub 2009 Apr 15. PMID: 19515491
Article Published Date : Aug 28, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Blood-Brain-Barrier Disorders, Brain Damage, Brain Injury: Traumatic, Cognitive Decline/Dysfunction
Pharmacological Actions : Anticarcinogenic Agents, Neuroprotective Agents
[+]

Sulforaphane improves LPS-induced spatial learning and memory dysfunction, likely by upregulating neurogenesis through the BDNF-mTOR pathway.Jan 15, 2018

Pubmed Data : Neuroscience. 2018 09 15 ;388:357-366. Epub 2018 Aug 4. PMID: 30086367
Article Published Date : Jan 15, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Neurogenesis
Additional Keywords : Brain-derived neurotrophic factor modulator, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane improves neuronal mitochondrial function in brain tissue in acute carbon monoxide poisoning.Dec 15, 2016

Pubmed Data : Basic Clin Pharmacol Toxicol. 2016 Dec 16. Epub 2016 Dec 16. PMID: 27983767
Article Published Date : Dec 15, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Carbon Monoxide Poisoning
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injuryFeb 08, 2017

Pubmed Data : Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID: 28189971
Article Published Date : Feb 08, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Sulforaphane increases cell-mediated immune response in melanoma-induced metastatic tumor-bearing mice.Apr 01, 2010

Pubmed Data : J Clin Invest. 2010 Apr 1;120(4):1043-55. Epub 2010 Mar 24. PMID: 17849266
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Interleukin-1 beta downregulation, Interleukin-2 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane increases the effectiveness of various cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.Jun 01, 2004

Pubmed Data : J Med Food. 2004 Summer;7(2):157-61. PMID: 20940707
Article Published Date : Jun 01, 2004
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancers: Multi-Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Sulforaphane induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting NF-κB signaling pathway.May 25, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2015 May 26. Epub 2015 May 26. PMID: 26013831
Article Published Date : May 25, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Duchenne's Muscular Dystrophy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.Nov 01, 2007

Pubmed Data : Oncol Rep. 2007 Nov;18(5):1263-8. PMID: 17914583
Article Published Date : Nov 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Osteosarcoma
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane induces cell cycle arrest and programmed cell death in human lung cancer cells and retards growth of human lung cancer tumors in a xenograft animal model.Oct 15, 2008

Pubmed Data : J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID: 18855447
Article Published Date : Oct 15, 2008
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Sulforaphane induces cell death in primary human colorectal cancer. Jan 01, 2012

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:415231. Epub 2011 Jul 17. PMID: 21804859
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Sulforaphane induces miR135b-5p and its target gene to inhibit the progression of pancreatic cancer.Sep 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Ther Oncolytics. 2019 Sep 27 ;14:74-81. Epub 2019 Apr 6. PMID: 31044154
Article Published Date : Sep 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.May 28, 2002

Pubmed Data : Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5. PMID: 12032331
Article Published Date : May 28, 2002
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Gastric Cancer, Helicobacter Pylori Infection
Additional Keywords : Multi-Drug Resistant Pathogens
[+]

Sulforaphane inhibits multiple inflammasomes through a novel mechanism and contributes to our understanding of the beneficial effects of sulforaphane.Aug 11, 2015

Pubmed Data : J Leukoc Biol. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26269198
Article Published Date : Aug 11, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gout, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Sulforaphane inhibits oral cancer cell growth in vitro and in an animal model.Jan 01, 2010

Pubmed Data : J Clin Biochem Nutr. 2010 Jan;46(1):60-7. Epub 2009 Dec 29. PMID: 20104266
Article Published Date : Jan 01, 2010
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oral Cancer
Pharmacological Actions : Cell cycle arrest
[+]

Sulforaphane inhibits pancreatic cancer proliferation through AMPK activation and Nrf2 translocation in vitro and in vivo.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;50(3):1201-1215. Epub 2018 Oct 24. PMID: 30355942
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Tumor, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Nrf2 activation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in association with increased cytotoxicity of natural killer cells.Mar 01, 2009

Pubmed Data : Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. PMID: 19223537
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Low Immune Function: Natural Killer Cells, Lung Cancer, Prostate Cancer
Pharmacological Actions : Anti-Angiogenic, Anticarcinogenic Agents, Antiproliferative , Apoptotic
[+]

Sulforaphane inhibits respiratory syncytial virus replication and virus-induced inflammation in the lungs of mice.Jan 15, 2009

Pubmed Data : Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50. Epub 2008 Oct 17. PMID: 18931336
Article Published Date : Jan 15, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Respiratory Syncytial Virus Infections, Respiratory Tract Infections
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiviral Agents
[+]

Sulforaphane inhibits the acquisition of tobacco smoke-induced lung cancer stem cell-like properties.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Theranostics. 2019 ;9(16):4827-4840. Epub 2019 Jul 9. PMID: 31367260
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane inhibits vestibular schwannoma growth in vitro and in vivo.Nov 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 2 ;6:36215. Epub 2016 Aug 2. PMID: 27805058
Article Published Date : Nov 01, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Schwannoma: Vestibular
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID: 26036303
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Sulforaphane is a promising agent to restore glucose tolerance through upregulation of insulin signaling in obese mice.Sep 19, 2018

Pubmed Data : Food Funct. 2018 Sep 19 ;9(9):4695-4701. PMID: 30091431
Article Published Date : Sep 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Insulin Resistance
Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
Problem Substances : Insulin
[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056
Article Published Date : May 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aflatoxicosis, Liver Cancer, Liver Damage: Aflatoxin-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Problem Substances : Aflatoxin
[+]

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID: 26531002
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-E2-Related Factor-2 (Nrf2) Modulator, Prostaglandin PGE2 downregulation
[+]

Sulforaphane may be a potential compound that can inhibit Aβ oligomer production in Alzheimer's disease.Dec 31, 2017

Pubmed Data : J Alzheimers Dis. 2018 ;62(4):1803-1813. PMID: 29614663
Article Published Date : Dec 31, 2017
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane may have therapeutic value in the treatment of rheumatoid arthritis.Jan 01, 2010

Pubmed Data : Arthritis Rheum. 2010 Jan;62(1):159-70. PMID: 20039434
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane may modulate serotonin levels.Jul 01, 2008

Pubmed Data : Cancer Res. 2008 Jul 1;68(13):5487-91. PMID: 18593952
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Serotonin Disorders
Pharmacological Actions : Serotonergic
[+]

Sulforaphane might be a promising therapeutic agent for cognitive enhancement in Alzheimer's disease.Jun 01, 2016

Pubmed Data : Neurochem Res. 2016 Jun 2. Epub 2016 Jun 2. PMID: 27255600
Article Published Date : Jun 01, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane might emerge as a novel strategy to protect the bladder against ischemia-induced oxidative damage.Nov 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 8 ;6:36110. Epub 2016 Aug 8. PMID: 27824068
Article Published Date : Nov 07, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors
[+]

Sulforaphane normalizes intestinal flora and enhances gut barrier in mice with BBN-induced bladder cancer.Jan 11, 2018

Pubmed Data : Mol Nutr Food Res. 2018 12 ;62(24):e1800427. Epub 2018 Nov 22. PMID: 30302904
Article Published Date : Jan 11, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Gastrointestinal Agents, Interleukin-6 Downregulation
[+]

Sulforaphane normalizes the kidney epigenome and improves blood pressure in hypertensive rats.Nov 03, 2011

Pubmed Data : Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID: 22052072
Article Published Date : Nov 03, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Hypertension, Kidney Diseases
Pharmacological Actions : Hypotensive
Additional Keywords : Epigenetic Modification
[+]

Sulforaphane offers protection against angiotensin II induced testicular injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:5374897. Epub 2017 Jan 16. PMID: 28191275
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
[+]

Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent.Jan 01, 2006

Pubmed Data : BMC Cancer. 2006;6:62. Epub 2006 Mar 15. PMID: 16539699
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling.Oct 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Cell. 2020 Oct 17:e13261. Epub 2020 Oct 17. PMID: 33067900
Article Published Date : Oct 16, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aging: Heart, Cardiovascular Diseases
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation
[+]

Sulforaphane prevents and/or retards adenoma formation in the gastrointestinal tract of mice.Oct 01, 2006

Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID: 16675473
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Colorectal Cancer, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Sulforaphane prevents cell death and inflammation in nephropathy.Jun 16, 2011

Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138
Article Published Date : Jun 16, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Nephropathy
Pharmacological Actions : Renoprotective
Problem Substances : Cisplatin
Adverse Pharmacological Actions : Nephrotoxic
[+]

Sulforaphane prevents chemically-induced skin cancer in mice.Aug 15, 2006

Pubmed Data : Cancer Res. 2006 Aug 15;66(16):8293-6. PMID: 16912211
Article Published Date : Aug 15, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Cancer, Skin Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity.Jan 06, 2016

Pubmed Data : Mol Neurobiol. 2016 Jan 7. Epub 2016 Jan 7. PMID: 26742517
Article Published Date : Jan 06, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Mercury Poisoning, Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
[+]

Sulforaphane prevents retinal ganglion cell death and acts as a potent neuroprotective modulator in retinal ischemia/reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. PMID: 31266422
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension.Mar 31, 2020

Pubmed Data : Am J Physiol Heart Circ Physiol. 2020 Apr 1 ;318(4):H853-H866. Epub 2020 Feb 28. PMID: 32108526
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Pulmonary Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Sulforaphane protects against benzo(a)pyrene induced toxicity. Sep 15, 2010

Pubmed Data : Pulm Pharmacol Ther. 2010 Sep 15. Epub 2010 Sep 15. PMID: 20833254
Article Published Date : Sep 15, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Antioxidants
[+]

Sulforaphane protects against cadmium-induced testicular injury by activation of Nrf2-ARE pathway.Jul 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Jul 19 ;23(7). Epub 2018 Jul 19. PMID: 30029485
Article Published Date : Jul 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Heavy Metal Toxicity, Oxidative Stress, Testicular Injury: Cadmium-Induced
Pharmacological Actions : Antioxidants, Apoptotic
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670
Article Published Date : Aug 15, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antioxidants
Problem Substances : Cisplatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Sulforaphane protects against cisplatin-induced nephrotoxicity.Aug 01, 2007

Pubmed Data : Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. PMID: 19913604
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Apoptotic, Renoprotective
[+]

Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.Feb 15, 2009

Pubmed Data : Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67. Epub 2008 Nov 21. PMID: 19071154
Article Published Date : Feb 15, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Beta Cell Protection, Beta Cell Regeneration
[+]

Sulforaphane protects against hypoxic-ischemic injury.Jul 09, 2010

Pubmed Data : Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID: 20417626
Article Published Date : Jul 09, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia, Hypoxia, Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.Jan 10, 2018

Pubmed Data : Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID: 30096613
Article Published Date : Jan 10, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiomyopathy, Hypoxia
Pharmacological Actions : Antioxidant Effects, Metallothionein Up-regulation, Nrf2 activation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic Db/Db mice. May 19, 2020

Pubmed Data : Life Sci. 2020 May 20 ;255:117823. Epub 2020 May 20. PMID: 32445760
Article Published Date : May 19, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Musculoskeletal Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Sulforaphane protects ischemic injury of hearts.Aug 11, 2008

Pubmed Data : Phytother Res. 2008 Aug 11. PMID: 19948220
Article Published Date : Aug 11, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Myocardial Infarction, Myocardial Ischemia
Pharmacological Actions : Antioxidants
[+]

Sulforaphane protects liver injury induced by intestinal ischemia in an animal model. Jun 28, 2010

Pubmed Data : World J Gastroenterol. 2010 Jun 28;16(24):3002-10. PMID: 20572303
Article Published Date : Jun 28, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Intestinal Diseases, Liver Disease
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
[+]

Sulforaphane protects piglet brains from neonatal hypoxic-ischemic injury.Dec 09, 2020

Pubmed Data : Dev Neurosci. 2020 Dec 10:1-11. Epub 2020 Dec 10. PMID: 33302269
Article Published Date : Dec 09, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane protects the male reproductive system of mice from obesity-induced damage.Oct 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2019 Oct 7 ;16(19). Epub 2019 Oct 7. PMID: 31591291
Article Published Date : Oct 06, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Hypogonadism, Obesity
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Nrf2 activation
[+]

Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.Jan 30, 2006

Pubmed Data : Neurosci Lett. 2006 Jan 30;393(2-3):108-12. Epub 2005 Oct 17. PMID: 16233958
Article Published Date : Jan 30, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia, Stroke: Recovery
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane reduces inflammation following spinal cord injury in mice.Jan 01, 2010

Pubmed Data : Ann Clin Lab Sci. 2010;40(4):354-60. PMID: 20947810
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane reduces the apoptosis of neurons in brain trauma-induced diffuse axonal injury.Jun 23, 2019

Pubmed Data : J Cell Biochem. 2019 Jun 24. Epub 2019 Jun 24. PMID: 31232487
Article Published Date : Jun 23, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Damage
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane significantly decreased leptin-induced vascular smooth muscle cell proliferation.Mar 09, 2016

Pubmed Data : J Nutr Biochem. 2016 Mar 10 ;32:73-84. Epub 2016 Mar 10. PMID: 27142739
Article Published Date : Mar 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Leptin Down-Regulation
Anti Therapeutic Actions : Western Diet
[+]

Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.Oct 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID: 29085055
Article Published Date : Oct 29, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.Jan 01, 2019

Pubmed Data : Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID: 30315662
Article Published Date : Jan 01, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Cancer: Prevention
Pharmacological Actions : Anti Inflammatory, Anticarcinogenic Agents, Antioxidant, Antioxidant Effects, Antiproliferative , Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Ultraviolet Radiation Induced Damage
[+]

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia, indicating it may have a therapeutic role in reducing brain inflammation.Jun 01, 2010

Pubmed Data : Inflamm Res. 2010 Jun;59(6):443-50. Epub 2009 Nov 19. PMID: 19924513
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain: Microglial Activation, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells In vitro and in vivo.Jan 23, 2019

Pubmed Data : Cancer Prev Res (Phila). 2019 Jan 24. Epub 2019 Jan 24. PMID: 30679159
Article Published Date : Jan 23, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats.Oct 01, 2009

Pubmed Data : J Appl Physiol. 2009 Oct;107(4):1028-36. Epub 2009 Aug 27. PMID: 19713431
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Muscle Damage: Exercise-Induced, Muscle Fatigue, Muscle Soreness, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma.Jul 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 15 ;855:276-284. Epub 2019 May 14. PMID: 31100413
Article Published Date : Jul 14, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Asthma
Pharmacological Actions : Antioxidants, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation
[+]

Sulforaphane treatment upregulates CHIP and has the potential to decrease the accumulation of Aβ and tau in patients with Alzheimer's disease.Apr 29, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Apr 30:e1800240. Epub 2018 Apr 30. PMID: 29714053
Article Published Date : Apr 29, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Heat Shock Protein Inducer, Neuroprotective Agents
[+]

Sulforaphane's anti-inflammatory, antioxidant, and neuroprotective benefits attentuate autoimmune encephalomyelitis in an animal model of Multiple Sclerosis.Jul 22, 2019

Pubmed Data : J Korean Med Sci. 2019 Jul 22 ;34(28):e197. Epub 2019 Jul 22. PMID: 31327180
Article Published Date : Jul 22, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Autoimmune Diseases, Multiple Sclerosis
Therapeutic Actions : anti-inflammatory, antioxidant, neuro-protective
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidant Effects, Neuroprotective Agents, Nitric Oxide Inhibitor
Additional Keywords : Antioxidant, Autoimmune Diseases, Cruciferous Vegetables, Multiple Sclerosis, Phytotherapy, Sulforaphane
[+]

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice. Dec 01, 2003

Pubmed Data : Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID: 14638516
Article Published Date : Dec 01, 2003
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Helicobacter Pylori Infection
Additional Keywords : Plant Extracts
[+]

Sulforaphane-containing broccoli sprout extracts protect against UV-light-induced skin carcinogenesis.Aug 28, 2006

Pubmed Data : Cancer Lett. 2006 Aug 28;240(2):243-52. Epub 2005 Nov 3. PMID: 16271437
Article Published Date : Aug 28, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : DNA damage, Light Sensitivity, Oxidative Stress, Skin Diseases: Photo-Aging
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Radioprotective
Additional Keywords : Plant Extracts
[+]

Sulforaphene induces apoptosis and inhibits the invasion of esophageal cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2019 ;19:342. Epub 2019 Dec 19. PMID: 31889894
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury. Oct 18, 2010

Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205
Article Published Date : Oct 18, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Injury: Traumatic, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2015 ;5(8):2516-30. Epub 2015 Jul 15. PMID: 26396928
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Lung Cancer, Ovarian Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Temporal efficacy of a sulforaphane-based broccoli sprout diet in prevention of breast cancer through modulation of epigenetic mechanisms.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2018 Aug ;11(8):451-464. Epub 2018 May 15. PMID: 29764806
Article Published Date : Jul 31, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli Sprouts, Cruciferous Vegetables, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Epigenetic Modification In Cancer
[+]

The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: role in epigenetic regulation.Jun 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jun 13 ;19(6). Epub 2018 Jun 13. PMID: 29899271
Article Published Date : Jun 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genistein, Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Natural Substance Synergy
[+]

The present study indicates that benzyl isothiocyanate has the ability to inhibit breast cancer-induced osteolytic bone resorption in vivo.Feb 08, 2018

Pubmed Data : Carcinogenesis. 2018 Feb 9 ;39(2):134-145. PMID: 29040431
Article Published Date : Feb 08, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Cachexia: Cancer
Pharmacological Actions : Anti-Cachexic Agents, Chemotherapeutic
[+]

The present study suggested that sulforaphane exerted a therapeutic effect in the atopic dermatitis.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1761-1771. Epub 2019 Jun 20. PMID: 31257541
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Atopic Dermatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

The result suggests that allyl isothiocyanate has anti-inflammatory potential to prevent DMBA- and MNU-induced mammary carcinogenesis.Dec 31, 2017

Pubmed Data : Breast Cancer. 2018 Jan ;25(1):50-59. Epub 2017 May 13. PMID: 28501931
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings indicate that benzyl isothiocyanate and phenethyl isothiocyanate ameliorate high fat diet-induced obesity and fatty liver.Jun 25, 2019

Pubmed Data : J Agric Food Chem. 2019 Jun 26 ;67(25):7136-7146. Epub 2019 Jun 18. PMID: 31240929
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Fatty Liver, Obesity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Anti-Obesity Agents
[+]

Young radish and sulforaphane protect against carbon tetrachloride-induced liver damage.May 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. PMID: 18460814
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Radish, Sulforaphane
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

β-phenylethyl isothiocyanate could be a functional ingredient for oral cancer prevention.Jul 16, 2018

Pubmed Data : Food Funct. 2018 Jul 17 ;9(7):3640-3656. PMID: 29923573
Article Published Date : Jul 16, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Sulforaphane suppresses obesity-related glomerulopathy-induced damage by enhancing autophagy via Nrf2.Jul 28, 2020

Pubmed Data : Life Sci. 2020 Jul 29 ;258:118153. Epub 2020 Jul 29. PMID: 32738361
Article Published Date : Jul 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Obesity
Pharmacological Actions : Autophagy Up-regulation
Additional Keywords : Anti-Obesity Agents
[+]

"Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway."Jun 30, 2012

Pubmed Data : Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID: 22565590
Article Published Date : Jun 30, 2012
Study Type : Commentary
Additional Links
Substances : Sulforaphane
Diseases : Glioma
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

"Sulforaphane and related mustard oils in focus of cancer prevention and therapy."Dec 06, 2012

Pubmed Data : Wien Med Wochenschr. 2012 Dec 7. Epub 2012 Dec 7. PMID: 23224634
Article Published Date : Dec 06, 2012
Study Type : Review
Additional Links
Substances : Cruciferous Vegetables, Mustard Oil, Sulforaphane
Diseases : Cancer Stem Cells
[+]

"Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90."Nov 30, 2012

Pubmed Data : J Nutr Biochem. 2012 Dec ;23(12):1617-26. Epub 2012 Mar 23. PMID: 22444872
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
[+]

"Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways."Oct 31, 2012

Pubmed Data : Oncol Rep. 2012 Nov ;28(5):1851-8. Epub 2012 Aug 22. PMID: 22922937
Article Published Date : Oct 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Multiple Myeloma
Pharmacological Actions : Chemosensitizer
[+]

"Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells."Jan 01, 2011

Pubmed Data : Front Biosci (Elite Ed). 2011 ;3:515-28. Epub 2011 Jan 1. PMID: 21196331
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancer Stem Cells, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Cancer Stem Cells, Drug Synergy
[+]

21 hTERT down-regulation by HDAC1 inhibition is a promising approach for delaying or preventing colorectal cancer.Feb 04, 2017

Pubmed Data : Curr Cancer Drug Targets. 2017 Feb 5. Epub 2017 Feb 5. PMID: 28176652
Article Published Date : Feb 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

A combination of benzyl isothiocyanate and sulforaphane have potent inhibitory activity in pancreatic cancer cells.Dec 01, 2002

Pubmed Data : Int J Cardiol. 2002 Dec;86(2-3):317-23. PMID: 19712481
Article Published Date : Dec 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

A combination of phenethyl isothiocyanate and TH588 has potential as a novel therapeutic strategy against pancreatic cancer.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Mar ;15(3):3240-3244. Epub 2017 Dec 29. PMID: 29435064
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
[+]

A natural compound from Wasabia japonica inhibited the viability of human chronic myelogenous leukemia K562 cells.Nov 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 23 ;9(12). Epub 2019 Nov 23. PMID: 31771225
Article Published Date : Nov 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Wasabi
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation, Cell cycle arrest
[+]

A review evaluating the modulation of miRNAs by dietary agents, which could potentially be exploited for inhibition of mutagenesis and carcinogenesis.Sep 30, 2012

Pubmed Data : Mutat Res. 2012 Oct-Dec;751(2):287-303. Epub 2012 Jun 7. PMID: 22683846
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Isoflavones, Isothiocyanates, Phospholipids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification
[+]

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

Pubmed Data : Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID: 26189518
Article Published Date : Jul 31, 2011
Study Type : Review
Additional Links
Substances : Caffeine, Capsaicin, Cinnamaldehyde, Curcumin, Diallyl sulfide, EGCG (Epigallocatechin gallate), Genistein, Lycopene, Resveratrol, Silymarin, Sulforaphane, Xanthohumol
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

A review of the cardioprotective potential of plant-derived molecules.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819852243. Epub 2019 May 26. PMID: 31205459
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Catechin , Diosgenin, Isoflavones, Quercetin, Sulforaphane
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

A review of the role of phytochemicals in cancer prevention.Oct 08, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 9 ;20(20). Epub 2019 Oct 9. PMID: 31600949
Article Published Date : Oct 08, 2019
Study Type : Review
Additional Links
Substances : Benzyl isothiocyanate , Capsaicin, Catechin , Cucurbitacin B , Isoflavones, Lycopene, Phenethyl isothiocyanate, Piperlongumine
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents
[+]

A variety of natural compounds may inhibit cancer stem cells. Sep 01, 2011

Pubmed Data : J Nutr Biochem. 2011 Sep ;22(9):799-806. Epub 2011 Feb 4. PMID: 21295962
Article Published Date : Sep 01, 2011
Study Type : Review
Additional Links
Substances : Carotenoids, Catechin , Curcumin, Isoflavones, Lycopene, Piperidines, Resveratrol, Stilbenes, Sulforaphane
Diseases : Cancer Stem Cells
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Activity of allyl isothiocyanate and Its synergy with fluconazole against Candida albicans biofilms.Apr 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2017 Apr 28 ;27(4):685-693. PMID: 28138121
Article Published Date : Apr 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Natural Substance/Drug Synergy
[+]

Allyl isothiocyanate ameliorates insulin resistance through the regulation of mitochondrial function.Sep 30, 2014

Pubmed Data : J Nutr Biochem. 2014 Oct ;25(10):1026-34. Epub 2014 Jun 5. PMID: 25034503
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.Sep 15, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2011 Sep 16 ;286(37):32259-67. Epub 2011 Jul 21. PMID: 21778226
Article Published Date : Sep 15, 2011
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Allyl isothiocyanate as a cancer chemopreventive phytochemical.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2010 Jan ;54(1):127-35. PMID: 19960458
Article Published Date : Dec 31, 2009
Study Type : Review
Additional Links
Substances : Isothiocyanates
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Phytotherapy
[+]

Allyl isothiocyanate induces autophagy through the up-regulation of beclin-1 in human prostate cancer cells.Oct 03, 2018

Pubmed Data : Am J Chin Med. 2018 Oct 4:1-19. Epub 2018 Oct 4. PMID: 30284468
Article Published Date : Oct 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Prostate Cancer
Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic
[+]

Allyl isothiocyanate induces cell toxicity by multiple pathways in human breast cancer cells.Dec 31, 2015

Pubmed Data : Am J Chin Med. 2016 ;44(2):415-37. PMID: 27080949
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells.Oct 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2010 Nov-Dec;3(6):1023-30. Epub 2010 Sep 15. PMID: 21472349
Article Published Date : Oct 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Chemotherapeutic
[+]

Allyl isothiocyanate inhibits the proliferation of renal carcinoma cell line GRC-1Nov 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2016 Nov 10 ;22:4283-4288. Epub 2016 Nov 10. PMID: 27834342
Article Published Date : Nov 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Allyl isothiocyanate may be beneficial in the treatment of human colorectal adenocarcinoma in the future.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2014 Jan ;31(1):189-96. Epub 2013 Nov 20. PMID: 24270601
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Cancer Metastasis, Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Allyl isothiocyanate nanoparticles have potential as therapeutic agents for bladder cancer and the enhancement of immune function.Mar 31, 2019

Pubmed Data : J Sci Food Agric. 2019 Apr ;99(6):3106-3116. Epub 2019 Jan 25. PMID: 30516283
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Immunomodulatory
Additional Keywords : Isothiocyanates
[+]

Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease.Feb 14, 2020

Pubmed Data : Life Sci. 2020 Feb 15 ;243:117291. Epub 2020 Jan 9. PMID: 31927049
Article Published Date : Feb 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells.Jul 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2010 Aug ;24(2):449-55. PMID: 20596632
Article Published Date : Jul 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis.Dec 31, 2017

Pubmed Data : Mol Cell Biochem. 2018 Jan ;437(1-2):1-12. Epub 2017 Jun 5. PMID: 28585088
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Nrf2 activation
[+]

Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion.Nov 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2010 Dec ;31(12):2105-10. Epub 2010 Oct 1. PMID: 20889681
Article Published Date : Nov 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer, Cancer Metastasis
Pharmacological Actions : Antiproliferative
[+]

Alyssin and iberin in cruciferous vegetables exert anticancer activity in HepG2 by increasing intracellular reactive oxygen species.Aug 12, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2019 Aug 13. Epub 2019 Aug 13. PMID: 31405267
Article Published Date : Aug 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Anti-rheumatic activity of phenethyl isothiocyanate via inhibition of histone deacetylase-1.May 31, 2020

Pubmed Data : Chem Biol Interact. 2020 Jun 1 ;324:109095. Epub 2020 Apr 11. PMID: 32289289
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Aqueous extract of glucoraphanin-rich broccoli sprouts inhibits formation of advanced glycation end products and attenuates inflammatory reactions.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:9823141. Epub 2018 Aug 8. PMID: 30174716
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells.Mar 31, 2016

Pubmed Data : Oncol Rep. 2016 Apr ;35(4):2089-96. Epub 2016 Jan 19. PMID: 26781422
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Gene Expression Regulation, Isothiocyanates
[+]

Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis.Feb 28, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Feb 29 ;393:114941. Epub 2020 Feb 29. PMID: 32126212
Article Published Date : Feb 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):832-840. Epub 2017 Jul 27. PMID: 28766686
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression in T lymphocytic leukemia cells.Apr 17, 2018

Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 18:e22054. Epub 2018 Apr 18. PMID: 29667773
Article Published Date : Apr 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Acute T cell Leukemias
Pharmacological Actions : Chemotherapeutic, interleukin-13 down-regulation
[+]

benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. Jun 30, 2016

Pubmed Data : Vojnosanit Pregl. 2016 Jul ;73(7):636-42. PMID: 29314795
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate downregulated the expression of virulence factors in staphylococcus aureus.Oct 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 31 ;20(21). Epub 2019 Oct 31. PMID: 31683671
Article Published Date : Oct 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antiviral Agents
[+]

Benzyl isothiocyanate induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells.Nov 30, 2016

Pubmed Data : Environ Toxicol. 2016 Dec ;31(12):1751-1760. Epub 2015 Sep 7. PMID: 28675694
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces apoptotic cell death in gefitinib-resistant NCI-H460 lung cancer cells.Aug 31, 2018

Pubmed Data : Anticancer Res. 2018 Sep ;38(9):5165-5176. PMID: 30194164
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 21 ;8(12):20220-20234. PMID: 28423628
Article Published Date : Mar 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate inhibits breast cancer cell tumorigenesisDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(10):17601-11. Epub 2015 Oct 15. PMID: 26770350
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPS-stimulated BV2 cells.Aug 31, 2016

Pubmed Data : Int J Mol Med. 2016 Sep ;38(3):912-8. Epub 2016 Jul 6. PMID: 27430883
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate is a potential therapeutic approach for oral squamous cell carcinoma.Apr 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2019 Apr 8 ;52(4):e8409. Epub 2019 Apr 8. PMID: 30970087
Article Published Date : Apr 07, 2019
Study Type : In Vitro Study
Additional Links
Substances :