Isothiocyanates

Name	AC	CK
Oxidative Stress	33	85
Prostate Cancer	31	49
Breast Cancer	29	42
Inflammation	16	40
Lung Cancer	15	40
Cancers: All	24	38
DNA damage	10	31
Autism Spectrum Disorders	2	30
Breast Cancer: Triple Negative	9	29
Colon Cancer	14	29
Pancreatic Cancer	17	29
Lung Cancer: Prevention	3	21
Melanoma	7	20
Bladder Cancer	7	18
Liver Cancer	15	18
Helicobacter Pylori Infection	5	17
Diabetes Mellitus: Type 2	6	16
Cancer Metastasis	11	15
Insulin Resistance	3	14
Prostate Cancer: Prevention	4	14
Smoking	2	14
Alzheimer's Disease	6	13
Cancers: Drug Resistant	8	13
Autism	2	12
Diesel Exhaust Particle Toxicity	3	12
Glutathione Deficiency	3	12
Air Pollution Linked Toxicity	2	11
Lipopolysaccharide-Induced Toxicity	8	11
Skin Diseases	2	11
Anemia: Sickle Cell	1	10
Asthma	1	10
Bladder Degeneration	1	10
COPD	1	10
Cognitive Decline/Dysfunction	5	10
Cystic Fibrosis	1	10
Fatty Liver	1	10
Gastritis	1	10
High Cholesterol	1	10
Hyperinsulinism	1	10
Lung Diseases	1	10
Prostate: PSA Doubling	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Schizophrenia	1	10
Glioblastoma	7	9
Endothelial Dysfunction	3	8
Ovarian Cancer	7	8
Cerebral Ischemia	4	7
Chemotherapy-Induced Toxicity: Cisplatin	4	7
Colorectal Cancer	5	7
Oral Cancer	5	7
Adenomatous Polyposis Coli	3	6
Chemically-Induced Liver Damage	4	6
Liver Cancer: Prevention	2	6
Benzo[a]pyrene-induced Toxicity	3	5
Brain Inflammation	4	5
Cancer Stem Cells	5	5
Chemotherapy-Induced Toxicity: Doxorubicin	4	5
Endothelial Damage	1	5
Hypoxia	4	5
Immune Disorders: Low Immune Function	3	5
Leukemia	5	5
Neurodegenerative Diseases	4	5
Obesity	3	5
Acetaminophen (Tylenol) Toxicity	2	4
Aflatoxicosis	3	4
Aspirin-Induced Toxicity	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Cadmium Poisoning	3	4
Carcinoma: Non-Small-Cell Lung	3	4
Depression	2	4
Diabetic Complications	2	4
Diabetic Nephropathy	3	4
Gastric Cancer	3	4
Intestinal Polyps	2	4
NSAID-induced toxicity	2	4
Nicotine/Tobacco Toxicity	1	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Skin Cancer	3	4
Skin Cancer: Prevention	2	4
Spinal Cord Injuries	2	4
Traumatic Brain Injury	2	4
Advanced Glycation End products (AGE)	2	3
Aging Skin	2	3
Bacterial Infections and Mycoses	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Brain Damage	2	3
Cardiovascular Diseases	3	3
Cervical Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Drug-Induced Toxicity: Indomethacin	2	3
Gastric Ulcer	2	3
Glioma	2	3
Head and Neck Cancer	3	3
Hydrogen Peroxide Induced Toxicity	3	3
Intestinal Diseases	2	3
Liver Damage: Aflatoxin-Induced	2	3
Low Disorders: Low TH1	2	3
Melanoma: Metastatic	2	3
Multiple Myeloma	2	3
Myocardial Ischemia	2	3
Nasopharyngeal Cancer	2	3
Osteosarcoma	2	3
Parkinson's Disease	3	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Promyelocytic leukemia	3	3
Rheumatoid Arthritis	2	3
Skin Diseases: Photo-Aging	2	3
Aging	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Atherosclerosis	1	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Breast Cancer: Metastatic	2	2
Cachexia: Cancer	1	2
Cancers: Multi-Drug Resistant	1	2
Carbon Monoxide Poisoning	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Depressive Disorder	1	2
Diabetes Mellitus: Type 1	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Duchenne's Muscular Dystrophy	1	2
Ehrlich carcinoma	1	2
Epstein-Barr Virus Infections	1	2
Gastrointestinal Cancer	1	2
Glioblastoma Multiforme	1	2
Gout	1	2
Gram-Negative Bacterial Infections	1	2
Gram-Positive Bacterial Infections	1	2
Heart Failure	1	2
High Fat Diet	1	2
Hypertension	1	2
Hypoglycemia	2	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Intoxication	1	2
Ischemia	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Light Sensitivity	1	2
Liver Disease	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Mercury Poisoning	1	2
Muscle Damage: Exercise-Induced	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Myocardial Infarction	1	2
Nephropathy	1	2
Neurologic Disorders	1	2
Neuropathic Pain	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Serotonin Disorders	1	2
Stroke	1	2
Stroke: Recovery	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	2	2
Ulcerative Colitis	1	2
Acute T cell Leukemias	1	1
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Arsenic Poisoning	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Cardiac Hypertrophy	1	1
Cardiovascular Disease: Prevention	1	1
Cholangiocarcinoma	1	1
Cholesterol: LDL/HDL ratio	1	1
Colon Cancer: Prevention	1	1
Colorectal Tumors	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dystrophic retinal detachment (DRD)	1	1
Encephalomyelitis	1	1
Escherichia coli Infections	1	1
Excitotoxicity	1	1
Fibrosis	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
Hyperglycemia	1	1
IgE-Mediated Hypersensitivity	1	1
Keloid	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Macular Degeneration	1	1
Malignant Melanoma	1	1
Medulloblastoma	1	1
Melanism	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Multiple Sclerosis	1	1
Neuroblastoma	1	1
Oral Cancer: Prevention	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Pesticide Toxicity	1	1
Prediabetes	1	1
Pseudomonas aeruginosa	1	1
Restenosis	1	1
Retinal Diseases	1	1
Sciatic Nerve Crush Injury	1	1
Stomach Cancer	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1
Ultraviolet Radiation Induced Damage	1	1

Name	AC	CK
Antioxidants	74	176
Anticarcinogenic Agents	85	161
Apoptotic	102	146
Chemopreventive	63	130
Anti-Inflammatory Agents	48	124
Antiproliferative	69	116
Nrf2 activation	40	89
Neuroprotective Agents	33	74
Phase II Detoxification Enzyme Inducer	14	40
Cell cycle arrest	31	36
Anti-metastatic	23	32
Cytoprotective	5	31
Chemotherapeutic	21	29
NF-kappaB Inhibitor	25	28
Tumor Necrosis Factor (TNF) Alpha Inhibitor	17	28
Antineoplastic Agents	19	24
Interleukin-1 beta downregulation	15	23
Hepatoprotective	8	21
Interleukin-6 Downregulation	15	21
Cyclooxygenase 2 Inhibitors	14	20
Chemosensitizer	15	19
Histone deacetylase inhibitor	10	19
Enzyme Inhibitors	8	17
Matrix metalloproteinase-2 (MMP-2) inhibitor	10	15
Matrix metalloproteinase-9 (MMP-9) inhibitor	10	14
MicroRNA modulator	13	14
Genoprotective	3	12
Glutathione Upregulation	3	12
Hypolipidemic	2	12
Tumor Suppressor Protein p53 Upregulation	6	11
Anti-Allergic Agents	1	10
Cardioprotective	8	10
Insulin Down-Regulation	1	10
NF-E2-Related Factor-2 (Nrf2) Modulator	8	9
Anti-Apoptotic	4	7
Anti-Bacterial Agents	5	6
Immunomodulatory	4	6
Renoprotective	4	6
Anti-Angiogenic	4	5
Bcl-2 protein down-regulation	5	5
Heme oxygenase-1 up-regulation	5	5
Superoxide Dismutase Up-regulation	1	5
Antidepressive Agents	2	4
Antiviral Agents	3	4
Radioprotective	2	4
Wnt/β-catenin signaling pathway modulation	4	4
Anti-Ulcer Agents	2	3
Chemoprotective Agents	2	3
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	3
Prostaglandin PGE2 downregulation	2	3
Survivin Down-Regulation	3	3
Telomerase Inhibitor	3	3
Vascular Endothelial Growth Factor Inhibitors	2	3
Angiogenesis Inhibitors	1	2
Anti-Anxiety Agents	1	2
Anti-Cachexic Agents	1	2
Anti-Fibrotic	2	2
Anticonvulsants	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Autophagy Up-regulation	2	2
Cytotoxic	2	2
Detoxifier	2	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Gastroprotective	1	2
Heat Shock Protein Inducer	1	2
Hypotensive	1	2
Immunomodulatory: Th17 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Leptin Down-Regulation	1	2
Nitric Oxide Inhibitor	1	2
Phase I Detoxification Enzyme Inducer	1	2
Proteasome Inhibitors	2	2
Serotonergic	1	2
Anti-Glycation Agents	1	1
Anti-Proliferative	1	1
Antifungal Agents	1	1
Antimitotic Agents	1	1
Antimutagenic Agents	1	1
Appetite Suppresant	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
DNA Repair Up-regulation	1	1
Estrogen Receptor Modulators	1	1
Hypoglycemic Agents	1	1
Interferon Gamma Reducer	1	1
Interleukin-10 upregulation	1	1
Interleukin-4 upregulation	1	1
Interleukin-8 downregulation	1	1
Neuritogenic	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Radiosensitizer	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
Wnt/β-catenin pathway down-regulation	1	1
anti-inflammatory	1	1
interleukin-13 down-regulation	1	1

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973

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Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID: 22045030

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Air Pollution Linked Toxicity, DNA damage

Additional Keywords : Isothiocyanates

[+]

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

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Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Substances : Broccoli, Broccoli Sprouts, Sprouts, Sulforaphane

Diseases : Gastritis, Helicobacter Pylori Infection

[+]

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

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Pubmed Data : BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID: 20423504

Article Published Date : Dec 31, 2009

Study Type : Human Study

Additional Links

Substances : Cruciferous Vegetables, Isothiocyanates

Diseases : Lung Cancer, Lung Cancer: Prevention, Smoking

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Risk Reduction

[+]

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

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Pubmed Data : Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID: 25466142

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126

Article Published Date : Jul 03, 2019

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Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539

Article Published Date : Apr 29, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Schizophrenia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID: 30595796

Article Published Date : Jan 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Nrf2 activation

Additional Keywords : calorie restriction, High Sugar Diet, Isothiocyanates

[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

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Pubmed Data : Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID: 30226534

Article Published Date : Nov 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Female, Ovarian Cancer

Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, HER-2 oncoprotein down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Drug Synergy, Isothiocyanates

[+]

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

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Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Bladder Cancer

Pharmacological Actions : Chemopreventive

[+]

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

[+]

A dietary isothiocyanate-enriched moringa seed extract improves glucose tolerance in a high-fat-diet model.Jul 31, 2018

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Pubmed Data : Mol Carcinog. 2015 Jan ;54(1):72-82. Epub 2014 Apr 11. PMID: 24729546

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Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925

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Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579

Article Published Date : May 25, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress

Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation

[+]

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

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Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558

[+]

Phenethyl isothiocyanate treatment suppressed the proliferation of ALDH1 expressing cancer stem cells.Feb 26, 2019

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Pubmed Data : Int J Mol Sci. 2019 Feb 27 ;20(5). Epub 2019 Feb 27. PMID: 30818757

[+]

Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice.Oct 03, 2017

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Pubmed Data : J Nutr Biochem. 2017 Oct 4 ;51:69-79. Epub 2017 Oct 4. PMID: 29096318

Article Published Date : Oct 03, 2017

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Pharmacological Actions : Neuroprotective Agents

[+]

Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.Feb 05, 2017

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Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666

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Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151

Article Published Date : Aug 01, 2018

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

[+]

Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379

Article Published Date : Feb 01, 2019

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Dyslipidemias, Fatty Liver, Insulin Resistance

Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents, Insulin Sensitizers

Additional Keywords : Isothiocyanates

Problem Substances : Fructose

[+]

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

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Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562

Article Published Date : Nov 15, 2005

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Brain Edema, Traumatic Brain Injury

[+]

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Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID: 31217757

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Article Publish Status : This is a free article. Click here to read the complete article.

Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

Problem Substances : Insulin

[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

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Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056

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Pubmed Data : Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID: 22052072

Article Published Date : Nov 03, 2011

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Hypertension, Kidney Diseases

Pharmacological Actions : Hypotensive

Additional Keywords : Epigenetic Modification

[+]

Sulforaphane offers protection against angiotensin II induced testicular injury.Dec 31, 2016

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Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138

Article Published Date : Jun 16, 2011

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Pubmed Data : Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID: 20417626

Article Published Date : Jul 09, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Cerebral Ischemia, Hypoxia, Stroke

Pharmacological Actions : Neuroprotective Agents

[+]

Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.Jan 10, 2018

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Pubmed Data : Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID: 30096613

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Pubmed Data : Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID: 29085055

Article Published Date : Oct 29, 2017

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.Jan 01, 2019

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Pubmed Data : Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID: 30315662

[+]

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice. Dec 01, 2003

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Pubmed Data : Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID: 14638516

Article Published Date : Dec 01, 2003

Study Type : Transgenic Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Helicobacter Pylori Infection

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : J Agric Food Chem. 2019 Jun 26 ;67(25):7136-7146. Epub 2019 Jun 18. PMID: 31240929

Article Published Date : Jun 25, 2019

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate

Diseases : Fatty Liver, Obesity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Anti-Obesity Agents

[+]

Young radish and sulforaphane protect against carbon tetrachloride-induced liver damage.May 01, 2008

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Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. PMID: 18460814

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells.Mar 31, 2016

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Pubmed Data : Oncol Rep. 2016 Apr ;35(4):2089-96. Epub 2016 Jan 19. PMID: 26781422

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Benzyl isothiocyanate

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Gene Expression Regulation, Isothiocyanates

[+]

Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion.Aug 31, 2017

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Pubmed Data : Int J Oncol. 2017 Sep ;51(3):832-840. Epub 2017 Jul 27. PMID: 28766686

Article Published Date : Aug 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Isothiocyanates

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Food Chem Toxicol. 2016 Nov ;97:336-345. Epub 2016 Sep 28. PMID: 27693243

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Pubmed Data : J Drug Target. 2019 Jan ;27(1):82-93. Epub 2018 Sep 5. PMID: 29877111

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

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Substances : Isothiocyanates

Diseases : Sciatic Nerve Crush Injury

Pharmacological Actions : MicroRNA modulator, Neuritogenic

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Beta-phenylethyl isothiocyanate and curcumin work synergistically to inhibit prostate cancer cell signaling.Aug 01, 2006

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31. PMID: 16299382

Article Published Date : Aug 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Phenethyl isothiocyanate

Diseases : Prostate Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Isothiocyanates, Natural Substance Synergy

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Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa seed extract.Dec 31, 2016

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Given its anticarcinogenic, anti-inflammatory, antioxidant properties, these authors conclude that sulforaphane could be considered as a phytochemical at the forefront of natural medicine.May 23, 2018

In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis.Apr 30, 2015

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Pubmed Data : Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID: 26457242

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Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells.Jan 08, 2017

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Pubmed Data : Biochem Biophys Res Commun. 2017 09 9 ;491(1):209-216. Epub 2017 Jul 13. PMID: 28712871

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View the Evidence: 487 Abstracts with Isothiocyanates Research

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Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.Apr 04, 2017

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.Dec 01, 2018

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.Jul 08, 2019

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.Mar 11, 2018

Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro. Aug 01, 2019

Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.Jun 04, 2018

Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.Feb 01, 2019

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."May 28, 2012

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."Dec 31, 2011

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

A dietary isothiocyanate-enriched moringa seed extract improves glucose tolerance in a high-fat-diet model.Jul 31, 2018

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cells.Oct 31, 2018

Benzyl isothiocyanate inhibits prostate cancer development.Jan 21, 2016

Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer.Jan 09, 2017

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression.Dec 31, 2014

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.Jun 06, 2018

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.Oct 01, 2009

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation. Oct 30, 2007

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue. Jul 01, 2007

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Isothiocyanates

View the Evidence:
487 Abstracts with Isothiocyanates Research