Isothiocyanates

Name	AC	CK
Oxidative Stress	45	118
Breast Cancer	42	69
Inflammation	27	59
Prostate Cancer	37	58
Cancers: All	33	51
Lung Cancer	20	47
Autism Spectrum Disorders	6	43
Colon Cancer	20	39
Bladder Cancer	19	34
Pancreatic Cancer	20	34
Breast Cancer: Triple Negative	11	32
DNA damage	10	31
Diabetes Mellitus: Type 2	11	29
Liver Cancer	21	28
Insulin Resistance	8	26
Obesity	13	24
Air Pollution Linked Toxicity	3	21
Lung Cancer: Prevention	3	21
Melanoma	8	21
Lipopolysaccharide-Induced Toxicity	14	20
Cancer Metastasis	14	18
Fatty Liver	4	18
Ovarian Cancer	11	18
Colorectal Cancer	10	17
Helicobacter Pylori Infection	5	17
Cancers: Drug Resistant	9	14
Prostate Cancer: Prevention	4	14
Smoking	2	14
Alzheimer's Disease	6	13
Chemotherapy-Induced Toxicity: Cisplatin	6	13
Asthma	2	12
Autism	2	12
Diesel Exhaust Particle Toxicity	3	12
Glutathione Deficiency	3	12
Schizophrenia	2	11
Skin Diseases	2	11
Anemia: Sickle Cell	1	10
Benzene Toxicity	1	10
Bladder Degeneration	1	10
COPD	1	10
Cognitive Decline/Dysfunction	5	10
Cystic Fibrosis	1	10
Gastric Cancer	5	10
Gastritis	1	10
Glioblastoma	8	10
High Cholesterol	1	10
Hyperinsulinism	1	10
Leukemia	6	10
Lung Diseases	1	10
Osteoarthritis: Knee	1	10
Prostate: PSA Doubling	1	10
Psychiatric Disorders	1	10
Pulmonary Fibrosis	1	10
Radical Prostatectomy	1	10
Respiratory Diseases	1	10
Cadmium Poisoning	4	9
Chemically-Induced Liver Damage	5	8
Endothelial Dysfunction	3	8
High Fat Diet	4	8
Aging	2	7
Cancers	3	7
Carcinoma: Non-Small-Cell Lung	6	7
Cardiovascular Diseases	6	7
Cerebral Ischemia	4	7
Chemotherapy-Induced Toxicity: Doxorubicin	6	7
Hypoxia	5	7
Ischemia	4	7
Neurodegenerative Diseases	5	7
Oral Cancer	5	7
Adenomatous Polyposis Coli	3	6
Atherosclerosis	3	6
Brain Inflammation	5	6
Liver Cancer: Prevention	2	6
Nicotine/Tobacco Toxicity	2	6
Rheumatoid Arthritis	4	6
Skin Cancer: Prevention	3	6
Traumatic Brain Injury	3	6
Benzo[a]pyrene-induced Toxicity	3	5
Brain Damage	3	5
Breast Cancer: Estrogen	1	5
Cancer Stem Cells	5	5
Colorectal Cancer: Prevention	1	5
Endothelial Damage	1	5
Female	1	5
Fetal Alcoholism	1	5
Gastric Cancer: Prevention	1	5
Gastric Ulcer	3	5
Immune Disorders: Low Immune Function	3	5
Insulin Disorders	1	5
Lipid Peroxidation	1	5
Liver Damage	3	5
Nonalcoholic fatty liver disease (NAFLD)	3	5
Osteosarcoma	4	5
Skin Cancer	4	5
Acetaminophen (Tylenol) Toxicity	2	4
Aflatoxicosis	3	4
Alcohol Toxicity	2	4
Aspirin-Induced Toxicity	2	4
Brain Injury: Traumatic	2	4
Brain: Microglial Activation	2	4
Breast Cancer: Chemically-Induced	2	4
Cardiomyopathy	2	4
Cervical Cancer	4	4
Colitis	2	4
Depression	2	4
Diabetes Mellitus: Type 1	2	4
Diabetic Complications	2	4
Diabetic Nephropathy	3	4
Glioma	3	4
Head and Neck Cancer	4	4
Hydrogen Peroxide Induced Toxicity	4	4
Intestinal Polyps	2	4
Muscle Damage: Exercise-Induced	2	4
NSAID-induced toxicity	2	4
Nasopharyngeal Cancer	3	4
Organ Transplantation: Pancreatic Islet Cells	2	4
Parkinson's Disease	4	4
Spinal Cord Injuries	2	4
Stroke	2	4
Ulcerative Colitis	2	4
Advanced Glycation End products (AGE)	2	3
Aging Skin	2	3
Bacterial Infections and Mycoses	2	3
Blood-Brain-Barrier Disorders	2	3
Brain Cancer	3	3
Chemotherapy-Induced Toxicity	2	3
Diabetes Mellitus: Type 1: Prevention	2	3
Drug-Induced Toxicity: Indomethacin	2	3
Escherichia coli Infections	2	3
Hyperglycemia	2	3
Intestinal Diseases	2	3
Liver Damage: Aflatoxin-Induced	2	3
Liver Fibrosis	2	3
Low Disorders: Low TH1	2	3
Malignant Melanoma	2	3
Melanoma: Metastatic	2	3
Multiple Myeloma	2	3
Multiple Sclerosis	2	3
Myocardial Ischemia	2	3
Petroleum Exposure And Toxicity	2	3
Polycyclic aromatic hydrocarbon (PAH) toxicity	2	3
Promyelocytic leukemia	3	3
Skin Diseases: Photo-Aging	2	3
Squamous cell carcinoma	3	3
Aging: Heart	1	2
Alcoholic Liver Disease	1	2
Amphetamine Addiction/Withdrawal	1	2
Anxiety Disorders	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Bladder Dysfunction	1	2
Bladder Outlet Obstruction	1	2
Brain Edema	1	2
Brain Hypoxia	2	2
Brain: Oxidative Stress	1	2
Breast Cancer: Metastatic	2	2
C-Reactive Protein	1	2
Cachexia: Cancer	1	2
Cancers: Canine	1	2
Cancers: Multi-Drug Resistant	1	2
Carbon Monoxide Poisoning	1	2
Chemical Exposure	1	2
Chemical Weapon Agent Injury	1	2
Chronic Pain	1	2
Coronavirus Infection	1	2
Depressive Disorder	1	2
Diabetes: Cognitive Dysfunction	1	2
Diabetes: Memory Problems	1	2
Diabetes: Oxidative Stress	1	2
Duchenne's Muscular Dystrophy	1	2
Dyslipidemias	1	2
Ehrlich carcinoma	1	2
Endometriosis	1	2
Epstein-Barr Virus Infections	1	2
Esophageal Cancer	1	2
Gastrointestinal Cancer	1	2
Glioblastoma Multiforme	1	2
Gout	1	2
Gram-Negative Bacterial Infections	1	2
Gram-Positive Bacterial Infections	1	2
Heart Failure	1	2
Heavy Metal Toxicity	1	2
Hypertension	1	2
Hypoglycemia	2	2
Hypogonadism	1	2
Immune Dysregulation: TH1/TH2 imbalance	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	1	2
Intoxication	1	2
Kidney Diseases	1	2
Lead Poisoning	1	2
Light Sensitivity	1	2
Liver Cirrhosis	1	2
Liver Disease	1	2
Low Immune Function: Natural Killer Cells	1	2
Malathion Toxicity	1	2
Memory Disorders	1	2
Mercury Poisoning	1	2
Mitochondrial Dysfunction	1	2
Muscle Fatigue	1	2
Muscle Soreness	1	2
Musculoskeletal Diseases	1	2
Myocardial Infarction	1	2
Nephropathy	1	2
Neurologic Disorders	1	2
Neuropathic Pain	1	2
Organ Transplantation	1	2
Pulmonary Hypertension	1	2
Respiratory Syncytial Virus Infections	1	2
Respiratory Tract Infections	1	2
Salivary Gland Adenoid Cystic Carcinoma.	2	2
Salivary Gland Diseases	2	2
Schwannoma: Vestibular	1	2
Seizures	1	2
Sepsis	1	2
Serotonin Disorders	1	2
Sickle Cell Anemia	1	2
Stroke: Recovery	1	2
Testicular Injury: Cadmium-Induced	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Tumors	2	2
Ultraviolet Radiation Induced Damage	2	2
Acute T cell Leukemias	1	1
Allergies	1	1
Androgen-Induced Diseases	1	1
Aortic Plaques	1	1
Arsenic Poisoning	1	1
Bone Destructive Diseases: Over-Active Osteoclasts	1	1
Brain Injury: Hippocampal Damage	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Breast Cancer: Prevention	1	1
Candida Albicans	1	1
Cardiac Hypertrophy	1	1
Cardiovascular Disease: Prevention	1	1
Cholangiocarcinoma	1	1
Cholesterol: LDL/HDL ratio	1	1
Chronic Kidney Disease (CKD)	1	1
Chronic Obstructive Pulmonary Disease	1	1
Colon Cancer: Prevention	1	1
Colorectal Tumors	1	1
Dopamine Deficiency	1	1
Drug-Induced Toxicity	1	1
Dystrophic retinal detachment (DRD)	1	1
Encephalomyelitis	1	1
Excitotoxicity	1	1
Fibrosis	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Fungal Infection	1	1
Gastrointestinal Diseases	1	1
HDL: Low	1	1
HIV Infections	1	1
Hepatitis C	1	1
Heterocyclic Aromatic Amine Induced Toxicity	1	1
IgE-Mediated Hypersensitivity	1	1
Keloid	1	1
Kidney Cancer	1	1
Kidney Damage	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukemia: Chronic myelogenous leukemia (CML)	1	1
Liver Failure: Acute	1	1
Lymphoma	1	1
Macular Degeneration	1	1
Medulloblastoma	1	1
Melanism	1	1
Microcystis aeruginosa	1	1
Mitochondrial Diseases	1	1
Muscle Atrophy	1	1
Neuroblastoma	1	1
Neurological Conditions	1	1
Oral Cancer: Prevention	1	1
Osteoarthritis	1	1
Osteoporosis	1	1
Osteoporosis: Over-active Osteoclasts	1	1
Pancreatic Cancer Stem Cell	1	1
Pesticide Toxicity	1	1
Prediabetes	1	1
Pseudomonas aeruginosa	1	1
Restenosis	1	1
Retinal Diseases	1	1
Salmonella Infections	1	1
Schizophrenic Disorders	1	1
Sciatic Nerve Crush Injury	1	1
Staphylococcus aureus infection	1	1
Stomach Cancer	1	1
Striatonigral Degeneration: Autosomal Dominant	1	1
Sunburn	1	1
Thyroid Cancer	1	1

Name	AC	CK
Antioxidants	106	230
Apoptotic	135	208
Antiproliferative	113	192
Anticarcinogenic Agents	100	189
Anti-Inflammatory Agents	77	173
Chemopreventive	82	166
Nrf2 activation	79	159
Neuroprotective Agents	45	105
Cell cycle arrest	44	57
NF-kappaB Inhibitor	38	52
Anti-metastatic	31	47
Chemotherapeutic	33	44
Phase II Detoxification Enzyme Inducer	17	44
Tumor Necrosis Factor (TNF) Alpha Inhibitor	25	42
Hepatoprotective	17	39
Antioxidant Effects	14	38
Interleukin-6 Downregulation	23	35
Antineoplastic Agents	23	34
Interleukin-1 beta downregulation	20	32
Cytoprotective	5	31
Cyclooxygenase 2 Inhibitors	17	29
Chemosensitizer	21	28
Histone deacetylase inhibitor	15	26
Glutathione Upregulation	4	22
MicroRNA modulator	19	21
Matrix metalloproteinase-2 (MMP-2) inhibitor	14	20
Hypolipidemic	5	18
Tumor Suppressor Protein p53 Upregulation	9	18
Enzyme Inhibitors	8	17
Matrix metalloproteinase-9 (MMP-9) inhibitor	13	17
NF-E2-Related Factor-2 (Nrf2) Modulator	11	16
Cardioprotective	12	15
Anti-Apoptotic	6	14
Antioxidant	4	13
Heme oxygenase-1 up-regulation	10	13
Anti-Angiogenic	6	12
Detoxifier	3	12
Genoprotective	3	12
Anti Inflammatory	5	11
Superoxide Dismutase Up-regulation	4	11
Anti-Allergic Agents	1	10
Autophagy Up-regulation	6	10
Chondroprotective	1	10
Glutathione S-transferase Inhibitor	1	10
Immunomodulatory	7	10
Insulin Down-Regulation	1	10
Insulin Sensitizers	4	10
Gastrointestinal Agents	5	9
Glucose Uptake Optimization	3	8
Renoprotective	6	8
Anti-Bacterial Agents	6	7
Anti-Tumor	2	7
Bcl-2 protein down-regulation	7	7
Chemoprotective Agents	6	7
Wnt/β-catenin signaling pathway modulation	6	7
Anti-Proliferative	2	6
Malondialdehyde Down-regulation	3	6
Nitric Oxide Inhibitor	3	6
Wnt/β-catenin pathway down-regulation	2	6
Anti-Fibrotic	4	5
Anti-cancer	1	5
Antiviral Agents	4	5
HER-2 oncoprotein down-regulation	1	5
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	4	5
Hypoxia-inducible factor-1 (HIF-1) inhibitor	1	5
Immune Enhancing Properties	1	5
Interferon Gamma Reducer	3	5
NADPH Oxidase Inhibitors	1	5
Prostaglandin E Synthase-1 (PGES-1) Down-Regulation	1	5
Regenerative	1	5
Vascular Endothelial Growth Factor Inhibitors	3	5
Angiogenesis Inhibitors	2	4
Antidepressive Agents	2	4
Gastroprotective	2	4
Immunomodulatory: Th17 downregulation	2	4
Radioprotective	2	4
Anti-Ulcer Agents	2	3
Antifungal Agents	3	3
Cytotoxic	3	3
Hypoglycemic Agents	2	3
Interleukin-10 upregulation	2	3
Prostaglandin PGE2 downregulation	2	3
Survivin Down-Regulation	3	3
Telomerase Inhibitor	3	3
Anti-Adipogenic	1	2
Anti-Anxiety Agents	1	2
Anti-Cachexic Agents	1	2
Anti-Estrogenic	1	2
Anticonvulsants	1	2
Antimicrobial	1	2
Antinoceceptive	1	2
Autophagy Inhibitors	1	2
Brain-derived neurotrophic factor modulator	1	2
Epidermal growth factor receptor (EGFR) inhibitor	1	2
Fertility Agents: Male	1	2
Heat Shock Protein Inducer	1	2
Hypotensive	1	2
Interleukin-10 downregulation	1	2
Interleukin-17 downregulation	1	2
Interleukin-18 down-regulation	1	2
Interleukin-2 upregulation	1	2
Interleukin-23 Downregulation	1	2
Leptin Down-Regulation	1	2
Lipolytic	1	2
Malonaldehyde (MDA) Down-Regulation	1	2
Metallothionein Up-regulation	1	2
Neurogenesis	1	2
PI3K-AKT inhibitor	1	2
Peroxisome Proliferators	1	2
Phase I Detoxification Enzyme Inducer	1	2
Platelet aggregation inhibitor: collagen-induced aggregation	1	2
Proteasome Inhibitors	2	2
Radiosensitizer	2	2
Serotonergic	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Anti-Glycation Agents	1	1
Antimitotic Agents	1	1
Antimutagenic Agents	1	1
Appetite Suppresant	1	1
Beta-Defensin-2 Up-Regulation	1	1
Caspase-3 Activation	1	1
Cell Differentiation Inducer	1	1
DNA Repair Up-regulation	1	1
Estrogen Receptor Modulators	1	1
Interleukin-4 upregulation	1	1
Interleukin-8 downregulation	1	1
Neuritogenic	1	1
Osteoprotective	1	1
P21 Activation	1	1
Postaglandin PGE2 downregulation	1	1
Quinone Reductase-Inducer	1	1
Radiopharmaceuticals	1	1
Vascular Cell Adhesion Molecule-1 Inhibitor	1	1
Vascular Endothelial Growth Factor Regulator	1	1
anti-inflammatory	1	1
interleukin-13 down-regulation	1	1

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

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Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973

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Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID: 22045030

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Air Pollution Linked Toxicity, DNA damage

Additional Keywords : Isothiocyanates

[+]

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

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Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Substances : Broccoli, Broccoli Sprouts, Sprouts, Sulforaphane

Diseases : Gastritis, Helicobacter Pylori Infection

[+]

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

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Pubmed Data : BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID: 20423504

Article Published Date : Dec 31, 2009

Study Type : Human Study

Additional Links

Substances : Cruciferous Vegetables, Isothiocyanates

Diseases : Lung Cancer, Lung Cancer: Prevention, Smoking

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Risk Reduction

[+]

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

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Pubmed Data : Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID: 25466142

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126

Article Published Date : Jul 03, 2019

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Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539

Article Published Date : Apr 29, 2015

Study Type : Human Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Schizophrenia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID: 24742583

Article Published Date : Mar 29, 2014

Study Type : Human In Vitro

Additional Links

Substances : Cruciferous Vegetables, Sulforaphane

Diseases : Cancers: Drug Resistant, Pancreatic Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemotherapeutic

Additional Keywords : Cancer Stem Cells, Dietary Concentrations

[+]

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID: 30595796

Article Published Date : Jan 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Nrf2 activation

Additional Keywords : calorie restriction, High Sugar Diet, Isothiocyanates

[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

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Pubmed Data : Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID: 30226534

Article Published Date : Nov 01, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Female, Ovarian Cancer

Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, HER-2 oncoprotein down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Drug Synergy, Isothiocyanates

[+]

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

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Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615

Article Published Date : Oct 31, 2012

Study Type : Animal Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Bladder Cancer

Pharmacological Actions : Chemopreventive

[+]

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Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492

Article Published Date : Aug 22, 2012

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity

[+]

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Pubmed Data : Carcinogenesis. 2003 Oct ;24(10):1665-70. Epub 2003 Aug 1. PMID: 12896904

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Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1674-83. Epub 2011 Mar 3. PMID: 21376772

Article Published Date : Jul 31, 2011

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate , Catechin , Ellagic Acid

Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage

Pharmacological Actions : Anticarcinogenic Agents

Additional Keywords : Isothiocyanates

Problem Substances : Benzo(a)pyrene

[+]

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

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Pubmed Data : Environ Toxicol. 2018 Nov ;33(11):1097-1104. Epub 2018 Jul 4. PMID: 29972272

Article Published Date : Oct 31, 2018

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Antiproliferative

[+]

Benzyl isothiocyanate inhibits prostate cancer development.Jan 21, 2016

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Pubmed Data : Int J Mol Sci. 2016 02 22 ;17(2):264. Epub 2016 Feb 22. PMID: 26907265

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Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1808-1818. Epub 2019 Jun 18. PMID: 31257529

Article Published Date : Jul 31, 2019

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Wnt/β-catenin signaling pathway modulation

[+]

Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression.Dec 31, 2014

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Pubmed Data : Mol Carcinog. 2015 Jan ;54(1):72-82. Epub 2014 Apr 11. PMID: 24729546

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Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925

Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.Dec 31, 2018

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Pubmed Data : Chem Biol Interact. 2016 Jul 25 ;254:102-8. Epub 2016 May 27. PMID: 27241356

Article Published Date : Jul 24, 2016

Study Type : Animal Study

Additional Links

Substances : Isothiocyanates

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.Dec 31, 2016

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Pubmed Data : PLoS One. 2017 ;12(9):e0184709. Epub 2017 Sep 18. PMID: 28922365

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Pubmed Data : ACS Omega. 2020 Nov 3 ;5(43):28319-28332. Epub 2020 Oct 26. PMID: 33163815

Article Published Date : Nov 02, 2020

Study Type : Animal Study

Additional Links

Substances : Citrus naringin, Isothiocyanates

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

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Pubmed Data : Nutrients. 2020 Nov 27 ;12(12). Epub 2020 Nov 27. PMID: 33261070

Article Published Date : Nov 26, 2020

Study Type : Animal Study

Additional Links

Substances : Phenethyl isothiocyanate

Diseases : Atherosclerosis, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Phenethyl isothiocyanate treatment suppressed the proliferation of ALDH1 expressing cancer stem cells.Feb 26, 2019

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Pubmed Data : Int J Mol Sci. 2019 Feb 27 ;20(5). Epub 2019 Feb 27. PMID: 30818757

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Pubmed Data : Saudi J Biol Sci. 2020 Nov ;27(11):3145-3149. Epub 2020 Jul 14. PMID: 33100876

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Pubmed Data : Metabolism. 2020 Jan ;102:154002. Epub 2019 Nov 9. PMID: 31706979

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Cardiomyopathy, Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Nrf2 activation

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Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.Jan 09, 2016

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Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.Aug 01, 2018

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Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151

Article Published Date : Aug 01, 2018

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

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Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

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Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379

Article Published Date : Feb 01, 2019

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Dyslipidemias, Fatty Liver, Insulin Resistance

Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents, Insulin Sensitizers

Additional Keywords : Isothiocyanates

Problem Substances : Fructose

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Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

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Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562

Article Published Date : Nov 15, 2005

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : Brain Edema, Traumatic Brain Injury

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Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID: 31217757

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Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers

Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates

Problem Substances : Insulin

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Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

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Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

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Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056

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Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID: 16675473

Article Published Date : Oct 01, 2006

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : Adenomatous Polyposis Coli, Colorectal Cancer, Intestinal Polyps

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive

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Sulforaphane prevents cell death and inflammation in nephropathy.Jun 16, 2011

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Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138

Article Published Date : Jun 16, 2011

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Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

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Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670

Article Published Date : Aug 15, 2011

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Pubmed Data : Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID: 20417626

Article Published Date : Jul 09, 2010

Study Type : Animal Study

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Substances : Sulforaphane

Diseases : Cerebral Ischemia, Hypoxia, Stroke

Pharmacological Actions : Neuroprotective Agents

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Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.Jan 10, 2018

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Pubmed Data : Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID: 30096613

Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.Oct 29, 2017

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Pubmed Data : Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID: 29085055

Article Published Date : Oct 29, 2017

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction

Pharmacological Actions : Antioxidants, Nrf2 activation

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Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.Jan 01, 2019

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Pubmed Data : Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID: 30315662

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Pubmed Data : Breast Cancer. 2018 Jan ;25(1):50-59. Epub 2017 May 13. PMID: 28501931

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Isothiocyanates

Diseases : Breast Cancer, Breast Cancer: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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These findings indicate that benzyl isothiocyanate and phenethyl isothiocyanate ameliorate high fat diet-induced obesity and fatty liver.Jun 25, 2019

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Pubmed Data : J Agric Food Chem. 2019 Jun 26 ;67(25):7136-7146. Epub 2019 Jun 18. PMID: 31240929

Article Published Date : Jun 25, 2019

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate

Diseases : Fatty Liver, Obesity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Anti-Obesity Agents

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This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.Jun 30, 2020

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Pubmed Data : Biochemistry (Mosc). 2020 Jul ;85(7):833-837. PMID: 33040727

Article Published Date : Jun 30, 2020

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Resveratrol, Sulforaphane

Diseases : Coronavirus Infection, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Cytokine Storm

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Young radish and sulforaphane protect against carbon tetrachloride-induced liver damage.May 01, 2008

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Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. PMID: 18460814

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Pubmed Data : Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID: 22565590

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Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.Apr 04, 2017

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017