Isothiocyanates

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228 Diseases Researched for Isothiocyanates
NameACCKFocus
Oxidative Stress3385Locked
Prostate Cancer3149Locked
Breast Cancer2942Locked
Inflammation1640Locked
Lung Cancer1540Locked
Cancers: All2438Locked
DNA damage1031Locked
Autism Spectrum Disorders230Locked
Breast Cancer: Triple Negative 929Locked
Colon Cancer1429Locked
Pancreatic Cancer1729Locked
Lung Cancer: Prevention321Locked
Melanoma720Locked
Bladder Cancer718Locked
Liver Cancer1518Locked
Helicobacter Pylori Infection517Locked
Diabetes Mellitus: Type 2616Locked
Cancer Metastasis1115Locked
Insulin Resistance314Locked
Prostate Cancer: Prevention414Locked
Smoking214Locked
Alzheimer's Disease613Locked
Cancers: Drug Resistant813Locked
Autism212Locked
Diesel Exhaust Particle Toxicity 312Locked
Glutathione Deficiency 312Locked
Air Pollution Linked Toxicity211Locked
Lipopolysaccharide-Induced Toxicity811Locked
Skin Diseases211Locked
Anemia: Sickle Cell 110Locked
Asthma110Locked
Bladder Degeneration110Locked
COPD110Locked
Cognitive Decline/Dysfunction510Locked
Cystic Fibrosis110Locked
Fatty Liver110Locked
Gastritis110Locked
High Cholesterol110Locked
Hyperinsulinism110Locked
Lung Diseases110Locked
Prostate: PSA Doubling110Locked
Pulmonary Fibrosis110Locked
Radical Prostatectomy110Locked
Respiratory Diseases110Locked
Schizophrenia110Locked
Glioblastoma79Locked
Endothelial Dysfunction38Locked
Ovarian Cancer78Locked
Cerebral Ischemia47Locked
Chemotherapy-Induced Toxicity: Cisplatin47Locked
Colorectal Cancer57Locked
Oral Cancer57Locked
Adenomatous Polyposis Coli36Locked
Chemically-Induced Liver Damage46Locked
Liver Cancer: Prevention26Locked
Benzo[a]pyrene-induced Toxicity 35Locked
Brain Inflammation 45Locked
Cancer Stem Cells55Locked
Chemotherapy-Induced Toxicity: Doxorubicin45Locked
Endothelial Damage15Locked
Hypoxia45Locked
Immune Disorders: Low Immune Function35Locked
Leukemia55Locked
Neurodegenerative Diseases45Locked
Obesity35Locked
Acetaminophen (Tylenol) Toxicity 24Locked
Aflatoxicosis34Locked
Aspirin-Induced Toxicity 24Locked
Brain Injury: Traumatic24Locked
Brain: Microglial Activation24Locked
Cadmium Poisoning 34Locked
Carcinoma: Non-Small-Cell Lung34Locked
Depression24Locked
Diabetic Complications24Locked
Diabetic Nephropathy34Locked
Gastric Cancer34Locked
Intestinal Polyps24Locked
NSAID-induced toxicity 24Locked
Nicotine/Tobacco Toxicity 14Locked
Organ Transplantation: Pancreatic Islet Cells24Locked
Skin Cancer34Locked
Skin Cancer: Prevention24Locked
Spinal Cord Injuries24Locked
Traumatic Brain Injury24Locked
Advanced Glycation End products (AGE)23Locked
Aging Skin23Locked
Bacterial Infections and Mycoses23Locked
Blood-Brain-Barrier Disorders23Locked
Brain Cancer33Locked
Brain Damage23Locked
Cardiovascular Diseases33Locked
Cervical Cancer33Locked
Chemotherapy-Induced Toxicity23Locked
Diabetes Mellitus: Type 1: Prevention23Locked
Drug-Induced Toxicity: Indomethacin23Locked
Gastric Ulcer23Locked
Glioma23Locked
Head and Neck Cancer33Locked
Hydrogen Peroxide Induced Toxicity33Locked
Intestinal Diseases23Locked
Liver Damage: Aflatoxin-Induced23Locked
Low Disorders: Low TH123Locked
Melanoma: Metastatic23Locked
Multiple Myeloma23Locked
Myocardial Ischemia23Locked
Nasopharyngeal Cancer23Locked
Osteosarcoma23Locked
Parkinson's Disease33Locked
Petroleum Exposure And Toxicity23Locked
Polycyclic aromatic hydrocarbon (PAH) toxicity23Locked
Promyelocytic leukemia 33Locked
Rheumatoid Arthritis23Locked
Skin Diseases: Photo-Aging23Locked
Aging12Locked
Amphetamine Addiction/Withdrawal12Locked
Anxiety Disorders12Locked
Atherosclerosis12Locked
Bladder Dysfunction 12Locked
Bladder Outlet Obstruction12Locked
Brain Edema12Locked
Brain Hypoxia22Locked
Breast Cancer: Metastatic22Locked
Cachexia: Cancer12Locked
Cancers: Multi-Drug Resistant12Locked
Carbon Monoxide Poisoning 12Locked
Chemical Exposure12Locked
Chemical Weapon Agent Injury 12Locked
Depressive Disorder12Locked
Diabetes Mellitus: Type 112Locked
Diabetes: Cognitive Dysfunction12Locked
Diabetes: Memory Problems12Locked
Duchenne's Muscular Dystrophy12Locked
Ehrlich carcinoma12Locked
Epstein-Barr Virus Infections12Locked
Gastrointestinal Cancer12Locked
Glioblastoma Multiforme12Locked
Gout12Locked
Gram-Negative Bacterial Infections12Locked
Gram-Positive Bacterial Infections12Locked
Heart Failure12Locked
High Fat Diet12Locked
Hypertension12Locked
Hypoglycemia22Locked
Immune Dysregulation: TH1/TH2 imbalance12Locked
Intoxication12Locked
Ischemia12Locked
Kidney Diseases12Locked
Lead Poisoning12Locked
Light Sensitivity12Locked
Liver Disease12Locked
Low Immune Function: Natural Killer Cells12Locked
Malathion Toxicity12Locked
Mercury Poisoning12Locked
Muscle Damage: Exercise-Induced12Locked
Muscle Fatigue12Locked
Muscle Soreness12Locked
Myocardial Infarction12Locked
Nephropathy12Locked
Neurologic Disorders12Locked
Neuropathic Pain12Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Organ Transplantation12Locked
Respiratory Syncytial Virus Infections12Locked
Respiratory Tract Infections12Locked
Salivary Gland Adenoid Cystic Carcinoma.22Locked
Salivary Gland Diseases22Locked
Schwannoma: Vestibular12Locked
Seizures12Locked
Serotonin Disorders12Locked
Stroke12Locked
Stroke: Recovery12Locked
Testicular Injury: Chemical/Metal Induced12Locked
Tumors22Locked
Ulcerative Colitis12Locked
Acute T cell Leukemias11Locked
Allergies11Locked
Androgen-Induced Diseases11Locked
Aortic Plaques11Locked
Arsenic Poisoning11Locked
Bone Destructive Diseases: Over-Active Osteoclasts11Locked
Brain Injury: Hippocampal Damage11Locked
Breast Cancer: HER-2 Overexpressed11Locked
Breast Cancer: Prevention11Locked
Cardiac Hypertrophy11Locked
Cardiovascular Disease: Prevention11Locked
Cholangiocarcinoma11Locked
Cholesterol: LDL/HDL ratio11Locked
Colon Cancer: Prevention11Locked
Colorectal Tumors11Locked
Dopamine Deficiency11Locked
Drug-Induced Toxicity 11Locked
Dystrophic retinal detachment (DRD)11Locked
Encephalomyelitis11Locked
Escherichia coli Infections11Locked
Excitotoxicity 11Locked
Fibrosis11Locked
Fungal Infection11Locked
Gastrointestinal Diseases11Locked
HDL: Low11Locked
HIV Infections11Locked
Hepatitis C11Locked
Heterocyclic Aromatic Amine Induced Toxicity11Locked
Hyperglycemia11Locked
IgE-Mediated Hypersensitivity11Locked
Keloid11Locked
Kidney Damage11Locked
Leukemia: Acute promyelocytic leukemia 11Locked
Macular Degeneration11Locked
Malignant Melanoma11Locked
Medulloblastoma11Locked
Melanism11Locked
Microcystis aeruginosa11Locked
Mitochondrial Diseases11Locked
Multiple Sclerosis11Locked
Neuroblastoma11Locked
Oral Cancer: Prevention11Locked
Osteoporosis: Over-active Osteoclasts11Locked
Pancreatic Cancer Stem Cell11Locked
Pesticide Toxicity 11Locked
Prediabetes11Locked
Pseudomonas aeruginosa11Locked
Restenosis11Locked
Retinal Diseases11Locked
Sciatic Nerve Crush Injury11Locked
Stomach Cancer11Locked
Striatonigral Degeneration: Autosomal Dominant11Locked
Sunburn11Locked
Ultraviolet Radiation Induced Damage11Locked
103 Pharmacological Actions Researched for Isothiocyanates
NameACCKFocus
Antioxidants74176Locked
Anticarcinogenic Agents85161Locked
Apoptotic102146Locked
Chemopreventive63130Locked
Anti-Inflammatory Agents48124Locked
Antiproliferative 69116Locked
Nrf2 activation4089Locked
Neuroprotective Agents3374Locked
Phase II Detoxification Enzyme Inducer1440Locked
Cell cycle arrest3136Locked
Anti-metastatic2332Locked
Cytoprotective531Locked
Chemotherapeutic2129Locked
NF-kappaB Inhibitor2528Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor1728Locked
Antineoplastic Agents1924Locked
Interleukin-1 beta downregulation1523Locked
Hepatoprotective821Locked
Interleukin-6 Downregulation1521Locked
Cyclooxygenase 2 Inhibitors1420Locked
Chemosensitizer1519Locked
Histone deacetylase inhibitor1019Locked
Enzyme Inhibitors817Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor1015Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor1014Locked
MicroRNA modulator1314Locked
Genoprotective312Locked
Glutathione Upregulation 312Locked
Hypolipidemic212Locked
Tumor Suppressor Protein p53 Upregulation611Locked
Anti-Allergic Agents110Locked
Cardioprotective810Locked
Insulin Down-Regulation110Locked
NF-E2-Related Factor-2 (Nrf2) Modulator89Locked
Anti-Apoptotic47Locked
Anti-Bacterial Agents56Locked
Immunomodulatory46Locked
Renoprotective46Locked
Anti-Angiogenic45Locked
Bcl-2 protein down-regulation55Locked
Heme oxygenase-1 up-regulation55Locked
Superoxide Dismutase Up-regulation15Locked
Antidepressive Agents24Locked
Antiviral Agents34Locked
Radioprotective24Locked
Wnt/β-catenin signaling pathway modulation44Locked
Anti-Ulcer Agents23Locked
Chemoprotective Agents23Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor23Locked
Prostaglandin PGE2 downregulation23Locked
Survivin Down-Regulation33Locked
Telomerase Inhibitor33Locked
Vascular Endothelial Growth Factor Inhibitors23Locked
Angiogenesis Inhibitors12Locked
Anti-Anxiety Agents12Locked
Anti-Cachexic Agents12Locked
Anti-Fibrotic22Locked
Anticonvulsants12Locked
Antinoceceptive 12Locked
Autophagy Inhibitors12Locked
Autophagy Up-regulation22Locked
Cytotoxic22Locked
Detoxifier22Locked
Epidermal growth factor receptor (EGFR) inhibitor12Locked
Gastroprotective12Locked
Heat Shock Protein Inducer12Locked
Hypotensive12Locked
Immunomodulatory: Th17 downregulation12Locked
Interleukin-17 downregulation12Locked
Interleukin-18 down-regulation12Locked
Interleukin-2 upregulation12Locked
Leptin Down-Regulation12Locked
Nitric Oxide Inhibitor12Locked
Phase I Detoxification Enzyme Inducer12Locked
Proteasome Inhibitors22Locked
Serotonergic12Locked
Anti-Glycation Agents11Locked
Anti-Proliferative11Locked
Antifungal Agents11Locked
Antimitotic Agents11Locked
Antimutagenic Agents11Locked
Appetite Suppresant11Locked
Beta-Defensin-2 Up-Regulation11Locked
Caspase-3 Activation11Locked
Cell Differentiation Inducer11Locked
DNA Repair Up-regulation11Locked
Estrogen Receptor Modulators11Locked
Hypoglycemic Agents11Locked
Interferon Gamma Reducer11Locked
Interleukin-10 upregulation11Locked
Interleukin-4 upregulation11Locked
Interleukin-8 downregulation11Locked
Neuritogenic11Locked
P21 Activation11Locked
Postaglandin PGE2 downregulation 11Locked
Quinone Reductase-Inducer11Locked
Radiopharmaceuticals11Locked
Radiosensitizer11Locked
Vascular Cell Adhesion Molecule-1 Inhibitor 11Locked
Vascular Endothelial Growth Factor Regulator11Locked
Wnt/β-catenin pathway down-regulation11Locked
anti-inflammatory11Locked
interleukin-13 down-regulation11Locked
Related Topics

The Following are Sub-Topics of Isothiocyanates

View the Evidence:
409 Abstracts with Isothiocyanates Research

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973
Article Published Date : Oct 17, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Epigenetic Modification In Cancer
[+]

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Pubmed Data : Int J Food Sci Nutr. 2012 Nov ;63(7):767-71. Epub 2012 Apr 26. PMID: 22537070
Article Published Date : Oct 31, 2012
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Hyperinsulinism, Insulin Resistance
Pharmacological Actions : Antioxidants, Insulin Down-Regulation
[+]

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID: 27071063
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Anemia: Sickle Cell
Additional Keywords : Gene Expression Regulation
[+]

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID: 22045030
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Air Pollution Linked Toxicity, DNA damage
Additional Keywords : Isothiocyanates
[+]

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Broccoli, Broccoli Sprouts, Sprouts, Sulforaphane
Diseases : Gastritis, Helicobacter Pylori Infection
[+]

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID: 20423504
Article Published Date : Dec 31, 2009
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Lung Cancer, Lung Cancer: Prevention, Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Risk Reduction
[+]

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Pubmed Data : Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID: 25466142
Article Published Date : Apr 14, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.Apr 04, 2017

Pubmed Data : J Nutr. 2017 Apr 5. Epub 2017 Apr 5. PMID: 28381528
Article Published Date : Apr 04, 2017
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2015 May 12. Epub 2015 May 12. PMID: 25968598
Article Published Date : May 11, 2015
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate: PSA Doubling, Radical Prostatectomy
Additional Keywords : Recurrence Risk, Significant Treatment Outcome
[+]

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Pubmed Data : Cancer Prev Res (Phila). 2018 Apr 24. Epub 2018 Apr 24. PMID: 29691233
Article Published Date : Apr 23, 2018
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive
[+]

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):918-26. Epub 2015 Apr 7. PMID: 25851421
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli, Isothiocyanates
Diseases : High Cholesterol
Pharmacological Actions : Hypolipidemic
[+]

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Autism. 2018 ;9:35. Epub 2018 May 30. PMID: 29854372
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism Spectrum Disorders
Pharmacological Actions : Antioxidants
[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID: 18950181
Article Published Date : Nov 26, 2008
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Raw versus Cooked
[+]

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;55(1):53-62. PMID: 16965241
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Glob Adv Health Med. 2017 ;6:2164957X17735826. Epub 2017 Oct 26. PMID: 29147630
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism
[+]

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Chemopreventive, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer, Bladder Degeneration, DNA damage
Pharmacological Actions : Chemopreventive, Genoprotective
[+]

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID: 26369337
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Asthma, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID: 17416783
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Skin Diseases
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Pubmed Data : Food Funct. 2014 Jan ;5(1):35-41. PMID: 24287881
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diesel Exhaust Particle Toxicity
Pharmacological Actions : Anti-Allergic Agents
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Proc Natl Acad Sci U S A. 2014 Oct 28 ;111(43):15550-5. Epub 2014 Oct 13. PMID: 25313065
Article Published Date : Oct 27, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Isothiocyanates, Sulforaphane
Diseases : Autism Spectrum Disorders, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cytoprotective, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Risk Factors
[+]

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539
Article Published Date : Apr 29, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Schizophrenia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653
Article Published Date : Nov 20, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Fatty Liver
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

Pubmed Data : Nutr Cancer. 2000;38(2):168-78. PMID: 11525594
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Raw versus Cooked
[+]

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0140963. Epub 2015 Nov 2. PMID: 26524341
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Additional Keywords : Food Vs. Supplement, Increased Bioavailability, Plant Extracts
[+]

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID: 25522265
Article Published Date : Feb 28, 2015
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
Additional Keywords : Absorption, Bioavailability, Dietary Modification
[+]

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID: 24742583
Article Published Date : Mar 29, 2014
Study Type : Human In Vitro
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Dietary Concentrations
[+]

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Pubmed Data : Food Funct. 2015 May 26. Epub 2015 May 26. PMID: 26008201
Article Published Date : May 25, 2015
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Endothelial Damage, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
[+]

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Pubmed Data : Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348. Epub 2016 Aug 16. PMID: 27636860
Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Cytoprotective, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Selective Cytotoxicity
[+]

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.Mar 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2018 Mar 12 ;15(1):75. Epub 2018 Mar 12. PMID: 29530050
Article Published Date : Mar 11, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625
Article Published Date : Dec 01, 2005
Study Type : Human In Vitro
Additional Links
Substances : Broccoli, Sulforaphane, Watercress
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Erucin, Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Chemopreventive
[+]

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."May 28, 2012

Pubmed Data : Mol Carcinog. 2012 May 29. Epub 2012 May 29. PMID: 22641235
Article Published Date : May 28, 2012
Study Type : Insect Study
Additional Links
Substances : Sulforaphane
Diseases : Epstein-Barr Virus Infections, Nasopharyngeal Cancer
[+]

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

Pubmed Data : J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID: 22853439
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2012 ;2012:821936. Epub 2012 Sep 23. PMID: 23050040
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetic Nephropathy
[+]

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

Pubmed Data : Psychopharmacology (Berl). 2012 Jul ;222(1):37-45. Epub 2011 Dec 27. PMID: 22200890
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Amphetamine Addiction/Withdrawal, Brain: Microglial Activation, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

Pubmed Data : Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID: 23201461
Article Published Date : Nov 29, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemical Weapon Agent Injury , Skin Cancer: Prevention
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865
Article Published Date : Sep 01, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492
Article Published Date : Aug 22, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity
[+]

A dietary isothiocyanate-enriched moringa seed extract improves glucose tolerance in a high-fat-diet model.Jul 31, 2018

Pubmed Data : J Funct Foods. 2018 Aug ;47:376-385. Epub 2018 Jun 9. PMID: 30930963
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents
[+]

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1674-83. Epub 2011 Mar 3. PMID: 21376772
Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Catechin , Ellagic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
Problem Substances : Benzo(a)pyrene
[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Isothiocyanates, Stilbenes
[+]

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cells.Oct 31, 2018

Pubmed Data : Environ Toxicol. 2018 Nov ;33(11):1097-1104. Epub 2018 Jul 4. PMID: 29972272
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antiproliferative
[+]

Benzyl isothiocyanate inhibits prostate cancer development.Jan 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 02 22 ;17(2):264. Epub 2016 Feb 22. PMID: 26907265
Article Published Date : Jan 21, 2016
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest, Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer.Jan 09, 2017

Pubmed Data : Sci Rep. 2017 Jan 10 ;7:40070. Epub 2017 Jan 10. PMID: 28071670
Article Published Date : Jan 09, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression.Dec 31, 2014

Pubmed Data : Mol Carcinog. 2015 Jan ;54(1):72-82. Epub 2014 Apr 11. PMID: 24729546
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer, High Fat Diet
Pharmacological Actions : Antiproliferative
Additional Keywords : Tumor Microenvironment
[+]

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 19144376
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Petroleum Exposure And Toxicity, Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Pubmed Data : J Nutr Biochem. 2016 Oct 11 ;39:134-144. Epub 2016 Aug 11. PMID: 27833054
Article Published Date : Oct 10, 2016
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Depression, Depressive Disorder, Inflammation
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
[+]

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.Oct 01, 2009

Pubmed Data : Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID: 19669099
Article Published Date : Oct 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation. Oct 30, 2007

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID: 17956979
Article Published Date : Oct 30, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Aging Skin
[+]

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue. Jul 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID: 17347138
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
[+]

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Pubmed Data : J Food Sci. 2010 Aug 1;75(6):H190-9. PMID: 20722931
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brussel sprouts, Sulforaphane
Diseases : Chemical Exposure, Intoxication
Pharmacological Actions : Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.May 25, 2015

Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579
Article Published Date : May 25, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
[+]

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Fig, Sulforaphane, Vitamin E
Diseases : Cadmium Poisoning , Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
Problem Substances : Cadmium
[+]

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Pubmed Data : Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28089829
Article Published Date : Jan 11, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Capsaicin, Piceatannol , Resveratrol, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance Synergy
[+]

Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2016 ;7(6):e2246. Epub 2016 Jun 2. PMID: 27253410
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Curcumin and phenethyl isothiocyanate have a synergistic inhibitory effect on the growth of human prostate xenografts. Jul 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 16423986
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Curcumin and phenyethylisothiocyanate inhibite mouse prostate cancer. Sep 01, 2008

Pubmed Data : Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 18437538
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID: 26107664
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Cognitive Decline/Dysfunction, Neurologic Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.Feb 15, 2017

Pubmed Data : Diabetes. 2017 Feb 16. Epub 2017 Feb 16. PMID: 28209760
Article Published Date : Feb 15, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation
[+]

Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0184709. Epub 2017 Sep 18. PMID: 28922365
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Isothiocyanates exhibit anti-myeloma activity. Aug 01, 2011

Pubmed Data : Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID: 21712538
Article Published Date : Aug 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Isothiocyanate, Sulforaphane
Diseases : Multiple Myeloma
Pharmacological Actions : Apoptotic
[+]

Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID: 29436058
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Ginseng, Resveratrol, Sulforaphane
Diseases : Chronic Pain, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Inflammatory Diet, Risk Factors
[+]

Oncogenic c-Myc is a target of sulforaphane to prevent and eliminate the onset of human prostate cancer.Mar 14, 2016

Pubmed Data : J Cell Biochem. 2016 Mar 15. Epub 2016 Mar 15. PMID: 26990292
Article Published Date : Mar 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.Sep 15, 2005

Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336
Article Published Date : Sep 15, 2005
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Phenethyl isothiocyanate, Sulforaphane
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity , Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate inhibits in vivo growth of xenograft tumors of human glioblastoma cells.Sep 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 10 ;23(9). Epub 2018 Sep 10. PMID: 30201893
Article Published Date : Sep 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative
[+]

Phenethyl isothiocyanate may act as a promising anticancer agent either alone or in combination with doxorubicin through apoptotic cell death induction.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2018 ;17(4):1328-1338. PMID: 30568691
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Ehrlich carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Phenethyl isothiocyanate treatment suppressed the proliferation of ALDH1 expressing cancer stem cells.Feb 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 27 ;20(5). Epub 2019 Feb 27. PMID: 30818757
Article Published Date : Feb 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Pre-treatment with sulforaphane or thymoquinone can reduce acetylsalicylic acid-induced gastric ulcers.Jun 14, 2016

Pubmed Data : J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID: 27363643
Article Published Date : Jun 14, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane, Thymoquinone
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective
[+]

Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.Apr 12, 2018

Pubmed Data : Carcinogenesis. 2018 Apr 13. Epub 2018 Apr 13. PMID: 29668854
Article Published Date : Apr 12, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
[+]

Protective effects of sulforaphane in experimental vascular cognitive impairment.Dec 31, 2017

Pubmed Data : J Cereb Blood Flow Metab. 2018 Jan 1:271678X18764083. Epub 2018 Jan 1. PMID: 29533123
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents, Nrf2 activation
[+]

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.Jan 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Differ. 2016 10 ;23(10):1615-27. Epub 2016 Jun 3. PMID: 27258787
Article Published Date : Jan 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

Sufloraphane has a protective effect on preserved pancreas and may have a potential clinical implication to improve hemodynamically unstable pancreas donor condition.Jan 01, 2004

Pubmed Data : Ann Transplant. 2004;9(3):68-71. PMID: 15759553
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions : Antioxidants
[+]

Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals. Oct 01, 2006

Pubmed Data : Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID: 16600309
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Lung Cancer, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.Jan 05, 2017

Pubmed Data : J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID: 28059653
Article Published Date : Jan 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Antiproliferative, Apoptotic, Cancer Stem Cells, glioblastoma (GBM), Sulforaphane
[+]

Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.Feb 18, 2019

Pubmed Data : Behav Brain Res. 2019 Feb 19 ;364:213-224. Epub 2019 Feb 19. PMID: 30790585
Article Published Date : Feb 18, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Autism
Pharmacological Actions : Antioxidants, Immunomodulatory: Th17 downregulation, Nrf2 activation
[+]

Sulforaphane ameliorates okadaic acid induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway.Oct 02, 2015

Pubmed Data : Mol Neurobiol. 2015 Oct 3. Epub 2015 Oct 3. PMID: 26433376
Article Published Date : Oct 02, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Inflammation , Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane ameliorates some features of clinical diabetic complications particularly the lipid profile and insulin responsiveness.Apr 19, 2016

Pubmed Data : Food Funct. 2016 Apr 20 ;7(4):2060-5. PMID: 27025193
Article Published Date : Apr 19, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetic Complications, Insulin Resistance
Pharmacological Actions : Hypolipidemic
[+]

Sulforaphane and curcumin protect against malathion toxicity. Jun 30, 2012

Pubmed Data : Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID: 22957429
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin, Sulforaphane
Diseases : Malathion Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sulforaphane and dibenzoylmethane alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers.Oct 15, 2007

Pubmed Data : Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926
Article Published Date : Oct 15, 2007
Study Type : Animal Study
Additional Links
Substances : Dibenzoylmethane (DBM), Sulforaphane
Diseases : Adenomatous Polyposis Coli, Gastrointestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive
[+]

Sulforaphane and NAC (N-acetyl-L-cysteine) upregulate T(H)1 immunity in aging.May 01, 2008

Pubmed Data : J Allergy Clin Immunol. 2008 May;121(5):1255-1261.e7. Epub 2008 Mar 5. PMID: 18325578
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Sulforaphane
Diseases : Aging, Immune Disorders: Low Immune Function, Immune Dysregulation: TH1/TH2 imbalance, Low Disorders: Low TH1
Pharmacological Actions : Antioxidants, Immunomodulatory
[+]

Sulforaphane and vitamin E could ameliorate cognitive decline and oxidative damage in pups with lead exposure at lactation from maternal milk.Nov 30, 2017

Pubmed Data : J Trace Elem Med Biol. 2017 Dec ;44:88-92. Epub 2017 Jun 15. PMID: 28965607
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane, Vitamin E
Diseases : Cognitive Decline/Dysfunction, Lead Poisoning
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Lead
[+]

Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice.Oct 03, 2017

Pubmed Data : J Nutr Biochem. 2017 Oct 4 ;51:69-79. Epub 2017 Oct 4. PMID: 29096318
Article Published Date : Oct 03, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.Feb 05, 2017

Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666
Article Published Date : Feb 05, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Helicobacter Pylori Infection, NSAID-induced toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Aspirin , Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sulforaphane could inhibit inflammation in human umbilical vein ECs exposed to advanced glycation end products.Apr 20, 2016

Pubmed Data : Nutr Metab Cardiovasc Dis. 2016 Apr 21. Epub 2016 Apr 21. PMID: 27212619
Article Published Date : Apr 20, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Sulforaphane could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat.Aug 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 Aug 9 ;39(3):901-907. Epub 2016 Aug 9. PMID: 27497670
Article Published Date : Aug 08, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes: Memory Problems, Diabetic Complications
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562
Article Published Date : Nov 15, 2005
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Edema, Traumatic Brain Injury
[+]

Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer. Aug 29, 2011

Pubmed Data : Nutr Cancer. 2011 Aug 29. Epub 2011 Aug 29. PMID: 21875325
Article Published Date : Aug 29, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug Synergy
[+]

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.Nov 01, 2008

Pubmed Data : Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID: 18980980
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma.Oct 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Oct 4 ;7(1):12651. Epub 2017 Oct 4. PMID: 28978924
Article Published Date : Oct 03, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Chemopreventive, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.Dec 01, 2006

Pubmed Data : Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 16952200
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Sulforaphane has anticonvulsant properties and could improve mitochondrial function.Sep 13, 2015

Pubmed Data : J Neurochem. 2015 Sep 14. Epub 2015 Sep 14. PMID: 26365487
Article Published Date : Sep 13, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Nrf2 activation
[+]

Sulforaphane has antidepressant and anxiolytic like activities in stressed mice model of depression.Dec 21, 2015

Pubmed Data : Behav Brain Res. 2015 Dec 22 ;301:55-62. Epub 2015 Dec 22. PMID: 26721468
Article Published Date : Dec 21, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane has both anti-nociceptive and anti-inflammatory actions.Jan 31, 2017

Pubmed Data : Inflammopharmacology. 2017 Feb ;25(1):99-106. Epub 2017 Jan 4. PMID: 28054242
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Sulforaphane has immunomodulatory properties.Aug 01, 2007

Pubmed Data : Phytomedicine. 2007 Aug;14(7-8):538-45. Epub 2006 Nov 3. PMID: 17084602
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
[+]

Sulforaphane has potential as a therapeutic agent to protect T2DM patients from cognitive deficiencies.Apr 19, 2018

Pubmed Data : Neuroscience. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29684505
Article Published Date : Apr 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane has preventive action in oxidative stress-mediated liver injury associated with acetaminophen (APAP)-induced toxicity.May 31, 2015

Pubmed Data : Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID: 25818464
Article Published Date : May 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Sulforaphane has significant protective effects against oxidative stress and could ameliorate bladder dysfunction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:7598294. Epub 2016 Jun 28. PMID: 27433291
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Dysfunction , Bladder Outlet Obstruction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane improved cardiac function and remodelling by inhibiting oxidative stress and inflammation.Mar 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Mar 12 ;24:1473-1483. Epub 2018 Mar 12. PMID: 29527002
Article Published Date : Mar 11, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Sulforaphane improved islet function in vivo, indicating that combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation.Feb 01, 2010

Pubmed Data : Muscle Nerve. 2010 Feb;41(2):185-90. PMID: 16504726
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Organ Transplantation, Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions : Anticarcinogenic Agents
[+]

Sulforaphane improves cognitive function administered following traumatic brain injury.Aug 28, 2009

Pubmed Data : Neurosci Lett. 2009 Aug 28;460(2):103-7. Epub 2009 Apr 15. PMID: 19515491
Article Published Date : Aug 28, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Blood-Brain-Barrier Disorders, Brain Damage, Brain Injury: Traumatic, Cognitive Decline/Dysfunction
Pharmacological Actions : Anticarcinogenic Agents, Neuroprotective Agents
[+]

Sulforaphane improves neuronal mitochondrial function in brain tissue in acute carbon monoxide poisoning.Dec 15, 2016

Pubmed Data : Basic Clin Pharmacol Toxicol. 2016 Dec 16. Epub 2016 Dec 16. PMID: 27983767
Article Published Date : Dec 15, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Carbon Monoxide Poisoning
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injuryFeb 08, 2017

Pubmed Data : Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID: 28189971
Article Published Date : Feb 08, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Sulforaphane increases cell-mediated immune response in melanoma-induced metastatic tumor-bearing mice.Apr 01, 2010

Pubmed Data : J Clin Invest. 2010 Apr 1;120(4):1043-55. Epub 2010 Mar 24. PMID: 17849266
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Interleukin-1 beta downregulation, Interleukin-2 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane increases the effectiveness of various cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.Jun 01, 2004

Pubmed Data : J Med Food. 2004 Summer;7(2):157-61. PMID: 20940707
Article Published Date : Jun 01, 2004
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancers: Multi-Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Sulforaphane induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting NF-κB signaling pathway.May 25, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2015 May 26. Epub 2015 May 26. PMID: 26013831
Article Published Date : May 25, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Duchenne's Muscular Dystrophy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.Nov 01, 2007

Pubmed Data : Oncol Rep. 2007 Nov;18(5):1263-8. PMID: 17914583
Article Published Date : Nov 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Osteosarcoma
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane induces cell cycle arrest and programmed cell death in human lung cancer cells and retards growth of human lung cancer tumors in a xenograft animal model.Oct 15, 2008

Pubmed Data : J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID: 18855447
Article Published Date : Oct 15, 2008
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Sulforaphane induces cell death in primary human colorectal cancer. Jan 01, 2012

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:415231. Epub 2011 Jul 17. PMID: 21804859
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.May 28, 2002

Pubmed Data : Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5. PMID: 12032331
Article Published Date : May 28, 2002
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Gastric Cancer, Helicobacter Pylori Infection
Additional Keywords : Multi-Drug Resistant Pathogens
[+]

Sulforaphane inhibits multiple inflammasomes through a novel mechanism and contributes to our understanding of the beneficial effects of sulforaphane.Aug 11, 2015

Pubmed Data : J Leukoc Biol. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26269198
Article Published Date : Aug 11, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gout, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Sulforaphane inhibits oral cancer cell growth in vitro and in an animal model.Jan 01, 2010

Pubmed Data : J Clin Biochem Nutr. 2010 Jan;46(1):60-7. Epub 2009 Dec 29. PMID: 20104266
Article Published Date : Jan 01, 2010
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oral Cancer
Pharmacological Actions : Cell cycle arrest
[+]

Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in association with increased cytotoxicity of natural killer cells.Mar 01, 2009

Pubmed Data : Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. PMID: 19223537
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Low Immune Function: Natural Killer Cells, Lung Cancer, Prostate Cancer
Pharmacological Actions : Anti-Angiogenic, Anticarcinogenic Agents, Antiproliferative , Apoptotic
[+]

Sulforaphane inhibits respiratory syncytial virus replication and virus-induced inflammation in the lungs of mice.Jan 15, 2009

Pubmed Data : Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50. Epub 2008 Oct 17. PMID: 18931336
Article Published Date : Jan 15, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Respiratory Syncytial Virus Infections, Respiratory Tract Infections
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiviral Agents
[+]

Sulforaphane inhibits vestibular schwannoma growth in vitro and in vivo.Nov 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 2 ;6:36215. Epub 2016 Aug 2. PMID: 27805058
Article Published Date : Nov 01, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Schwannoma: Vestibular
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID: 26036303
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056
Article Published Date : May 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aflatoxicosis, Liver Cancer, Liver Damage: Aflatoxin-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Problem Substances : Aflatoxin
[+]

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID: 26531002
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-E2-Related Factor-2 (Nrf2) Modulator, Prostaglandin PGE2 downregulation
[+]

Sulforaphane may be a potential compound that can inhibit Aβ oligomer production in Alzheimer's disease.Dec 31, 2017

Pubmed Data : J Alzheimers Dis. 2018 ;62(4):1803-1813. PMID: 29614663
Article Published Date : Dec 31, 2017
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane may have therapeutic value in the treatment of rheumatoid arthritis.Jan 01, 2010

Pubmed Data : Arthritis Rheum. 2010 Jan;62(1):159-70. PMID: 20039434
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane may modulate serotonin levels.Jul 01, 2008

Pubmed Data : Cancer Res. 2008 Jul 1;68(13):5487-91. PMID: 18593952
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Serotonin Disorders
Pharmacological Actions : Serotonergic
[+]

Sulforaphane might be a promising therapeutic agent for cognitive enhancement in Alzheimer's disease.Jun 01, 2016

Pubmed Data : Neurochem Res. 2016 Jun 2. Epub 2016 Jun 2. PMID: 27255600
Article Published Date : Jun 01, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane might emerge as a novel strategy to protect the bladder against ischemia-induced oxidative damage.Nov 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 8 ;6:36110. Epub 2016 Aug 8. PMID: 27824068
Article Published Date : Nov 07, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors
[+]

Sulforaphane normalizes the kidney epigenome and improves blood pressure in hypertensive rats.Nov 03, 2011

Pubmed Data : Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID: 22052072
Article Published Date : Nov 03, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Hypertension, Kidney Diseases
Pharmacological Actions : Hypotensive
Additional Keywords : Epigenetic Modification
[+]

Sulforaphane offers protection against angiotensin II induced testicular injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:5374897. Epub 2017 Jan 16. PMID: 28191275
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
[+]

Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent.Jan 01, 2006

Pubmed Data : BMC Cancer. 2006;6:62. Epub 2006 Mar 15. PMID: 16539699
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane prevents and/or retards adenoma formation in the gastrointestinal tract of mice.Oct 01, 2006

Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID: 16675473
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Colorectal Cancer, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Sulforaphane prevents cell death and inflammation in nephropathy.Jun 16, 2011

Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138
Article Published Date : Jun 16, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Nephropathy
Pharmacological Actions : Renoprotective
Problem Substances : Cisplatin
Adverse Pharmacological Actions : Nephrotoxic
[+]

Sulforaphane prevents chemically-induced skin cancer in mice.Aug 15, 2006

Pubmed Data : Cancer Res. 2006 Aug 15;66(16):8293-6. PMID: 16912211
Article Published Date : Aug 15, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Cancer, Skin Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity.Jan 06, 2016

Pubmed Data : Mol Neurobiol. 2016 Jan 7. Epub 2016 Jan 7. PMID: 26742517
Article Published Date : Jan 06, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Mercury Poisoning, Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
[+]

Sulforaphane protects against benzo(a)pyrene induced toxicity. Sep 15, 2010

Pubmed Data : Pulm Pharmacol Ther. 2010 Sep 15. Epub 2010 Sep 15. PMID: 20833254
Article Published Date : Sep 15, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Antioxidants
[+]

Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670
Article Published Date : Aug 15, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antioxidants
Problem Substances : Cisplatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Sulforaphane protects against cisplatin-induced nephrotoxicity.Aug 01, 2007

Pubmed Data : Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. PMID: 19913604
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Apoptotic, Renoprotective
[+]

Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.Feb 15, 2009

Pubmed Data : Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67. Epub 2008 Nov 21. PMID: 19071154
Article Published Date : Feb 15, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Beta Cell Protection, Beta Cell Regeneration
[+]

Sulforaphane protects against hypoxic-ischemic injury.Jul 09, 2010

Pubmed Data : Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID: 20417626
Article Published Date : Jul 09, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia, Hypoxia, Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane protects ischemic injury of hearts.Aug 11, 2008

Pubmed Data : Phytother Res. 2008 Aug 11. PMID: 19948220
Article Published Date : Aug 11, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Myocardial Infarction, Myocardial Ischemia
Pharmacological Actions : Antioxidants
[+]

Sulforaphane protects liver injury induced by intestinal ischemia in an animal model. Jun 28, 2010

Pubmed Data : World J Gastroenterol. 2010 Jun 28;16(24):3002-10. PMID: 20572303
Article Published Date : Jun 28, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Intestinal Diseases, Liver Disease
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
[+]

Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.Jan 30, 2006

Pubmed Data : Neurosci Lett. 2006 Jan 30;393(2-3):108-12. Epub 2005 Oct 17. PMID: 16233958
Article Published Date : Jan 30, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia, Stroke: Recovery
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane reduces inflammation following spinal cord injury in mice.Jan 01, 2010

Pubmed Data : Ann Clin Lab Sci. 2010;40(4):354-60. PMID: 20947810
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane significantly decreased leptin-induced vascular smooth muscle cell proliferation.Mar 09, 2016

Pubmed Data : J Nutr Biochem. 2016 Mar 10 ;32:73-84. Epub 2016 Mar 10. PMID: 27142739
Article Published Date : Mar 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Leptin Down-Regulation
Anti Therapeutic Actions : Western Diet
[+]

Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.Oct 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID: 29085055
Article Published Date : Oct 29, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia, indicating it may have a therapeutic role in reducing brain inflammation.Jun 01, 2010

Pubmed Data : Inflamm Res. 2010 Jun;59(6):443-50. Epub 2009 Nov 19. PMID: 19924513
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain: Microglial Activation, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells In vitro and in vivo.Jan 23, 2019

Pubmed Data : Cancer Prev Res (Phila). 2019 Jan 24. Epub 2019 Jan 24. PMID: 30679159
Article Published Date : Jan 23, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats.Oct 01, 2009

Pubmed Data : J Appl Physiol. 2009 Oct;107(4):1028-36. Epub 2009 Aug 27. PMID: 19713431
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Muscle Damage: Exercise-Induced, Muscle Fatigue, Muscle Soreness, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sulforaphane treatment upregulates CHIP and has the potential to decrease the accumulation of Aβ and tau in patients with Alzheimer's disease.Apr 29, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Apr 30:e1800240. Epub 2018 Apr 30. PMID: 29714053
Article Published Date : Apr 29, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Heat Shock Protein Inducer, Neuroprotective Agents
[+]

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice. Dec 01, 2003

Pubmed Data : Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID: 14638516
Article Published Date : Dec 01, 2003
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Helicobacter Pylori Infection
Additional Keywords : Plant Extracts
[+]

Sulforaphane-containing broccoli sprout extracts protect against UV-light-induced skin carcinogenesis.Aug 28, 2006

Pubmed Data : Cancer Lett. 2006 Aug 28;240(2):243-52. Epub 2005 Nov 3. PMID: 16271437
Article Published Date : Aug 28, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : DNA damage, Light Sensitivity, Oxidative Stress, Skin Diseases: Photo-Aging
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Radioprotective
Additional Keywords : Plant Extracts
[+]

Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury. Oct 18, 2010

Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205
Article Published Date : Oct 18, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Injury: Traumatic, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Temporal efficacy of a sulforaphane-based broccoli sprout diet in prevention of breast cancer through modulation of epigenetic mechanisms.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2018 Aug ;11(8):451-464. Epub 2018 May 15. PMID: 29764806
Article Published Date : Jul 31, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli Sprouts, Cruciferous Vegetables, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Epigenetic Modification In Cancer
[+]

The present study indicates that benzyl isothiocyanate has the ability to inhibit breast cancer-induced osteolytic bone resorption in vivo.Feb 08, 2018

Pubmed Data : Carcinogenesis. 2018 Feb 9 ;39(2):134-145. PMID: 29040431
Article Published Date : Feb 08, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Cachexia: Cancer
Pharmacological Actions : Anti-Cachexic Agents, Chemotherapeutic
[+]

Young radish and sulforaphane protect against carbon tetrachloride-induced liver damage.May 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. PMID: 18460814
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Radish, Sulforaphane
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

β-phenylethyl isothiocyanate could be a functional ingredient for oral cancer prevention.Jul 16, 2018

Pubmed Data : Food Funct. 2018 Jul 17 ;9(7):3640-3656. PMID: 29923573
Article Published Date : Jul 16, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

"Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway."Jun 30, 2012

Pubmed Data : Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID: 22565590
Article Published Date : Jun 30, 2012
Study Type : Commentary
Additional Links
Substances : Sulforaphane
Diseases : Glioma
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

"Sulforaphane and related mustard oils in focus of cancer prevention and therapy."Dec 06, 2012

Pubmed Data : Wien Med Wochenschr. 2012 Dec 7. Epub 2012 Dec 7. PMID: 23224634
Article Published Date : Dec 06, 2012
Study Type : Review
Additional Links
Substances : Cruciferous Vegetables, Mustard Oil, Sulforaphane
Diseases : Cancer Stem Cells
[+]

"Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90."Nov 30, 2012

Pubmed Data : J Nutr Biochem. 2012 Dec ;23(12):1617-26. Epub 2012 Mar 23. PMID: 22444872
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
[+]

"Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways."Oct 31, 2012

Pubmed Data : Oncol Rep. 2012 Nov ;28(5):1851-8. Epub 2012 Aug 22. PMID: 22922937
Article Published Date : Oct 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Multiple Myeloma
Pharmacological Actions : Chemosensitizer
[+]

"Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells."Jan 01, 2011

Pubmed Data : Front Biosci (Elite Ed). 2011 ;3:515-28. Epub 2011 Jan 1. PMID: 21196331
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancer Stem Cells, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Cancer Stem Cells, Drug Synergy
[+]

21 hTERT down-regulation by HDAC1 inhibition is a promising approach for delaying or preventing colorectal cancer.Feb 04, 2017

Pubmed Data : Curr Cancer Drug Targets. 2017 Feb 5. Epub 2017 Feb 5. PMID: 28176652
Article Published Date : Feb 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

A combination of benzyl isothiocyanate and sulforaphane have potent inhibitory activity in pancreatic cancer cells.Dec 01, 2002

Pubmed Data : Int J Cardiol. 2002 Dec;86(2-3):317-23. PMID: 19712481
Article Published Date : Dec 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

A combination of phenethyl isothiocyanate and TH588 has potential as a novel therapeutic strategy against pancreatic cancer.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Mar ;15(3):3240-3244. Epub 2017 Dec 29. PMID: 29435064
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
[+]

A review evaluating the modulation of miRNAs by dietary agents, which could potentially be exploited for inhibition of mutagenesis and carcinogenesis.Sep 30, 2012

Pubmed Data : Mutat Res. 2012 Oct-Dec;751(2):287-303. Epub 2012 Jun 7. PMID: 22683846
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Isoflavones, Isothiocyanates, Phospholipids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification
[+]

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

Pubmed Data : Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID: 26189518
Article Published Date : Jul 31, 2011
Study Type : Review
Additional Links
Substances : Caffeine, Capsaicin, Cinnamaldehyde, Curcumin, Diallyl sulfide, EGCG (Epigallocatechin gallate), Genistein, Lycopene, Resveratrol, Silymarin, Sulforaphane, Xanthohumol
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

A variety of natural compounds may inhibit cancer stem cells. Sep 01, 2011

Pubmed Data : J Nutr Biochem. 2011 Sep ;22(9):799-806. Epub 2011 Feb 4. PMID: 21295962
Article Published Date : Sep 01, 2011
Study Type : Review
Additional Links
Substances : Carotenoids, Catechin , Curcumin, Isoflavones, Lycopene, Piperidines, Resveratrol, Stilbenes, Sulforaphane
Diseases : Cancer Stem Cells
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Aqueous extract of glucoraphanin-rich broccoli sprouts inhibits formation of advanced glycation end products and attenuates inflammatory reactions.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:9823141. Epub 2018 Aug 8. PMID: 30174716
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells.Mar 31, 2016

Pubmed Data : Oncol Rep. 2016 Apr ;35(4):2089-96. Epub 2016 Jan 19. PMID: 26781422
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Gene Expression Regulation, Isothiocyanates
[+]

Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):832-840. Epub 2017 Jul 27. PMID: 28766686
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression in T lymphocytic leukemia cells.Apr 17, 2018

Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 18:e22054. Epub 2018 Apr 18. PMID: 29667773
Article Published Date : Apr 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Acute T cell Leukemias
Pharmacological Actions : Chemotherapeutic, interleukin-13 down-regulation
[+]

benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. Jun 30, 2016

Pubmed Data : Vojnosanit Pregl. 2016 Jul ;73(7):636-42. PMID: 29314795
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells.Nov 30, 2016

Pubmed Data : Environ Toxicol. 2016 Dec ;31(12):1751-1760. Epub 2015 Sep 7. PMID: 28675694
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces apoptotic cell death in gefitinib-resistant NCI-H460 lung cancer cells.Aug 31, 2018

Pubmed Data : Anticancer Res. 2018 Sep ;38(9):5165-5176. PMID: 30194164
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 21 ;8(12):20220-20234. PMID: 28423628
Article Published Date : Mar 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate inhibits breast cancer cell tumorigenesisDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(10):17601-11. Epub 2015 Oct 15. PMID: 26770350
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPS-stimulated BV2 cells.Aug 31, 2016

Pubmed Data : Int J Mol Med. 2016 Sep ;38(3):912-8. Epub 2016 Jul 6. PMID: 27430883
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage response.Oct 31, 2016

Pubmed Data : Food Chem Toxicol. 2016 Nov ;97:336-345. Epub 2016 Sep 28. PMID: 27693243
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Oral Cancer, Oxidative Stress
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Isothiocyanates
[+]

Benzyl-isothiocyanate induces apoptosis and inhibits migration and invasion of hepatocellular carcinoma cells in vitro.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2017 ;8(2):240-248. Epub 2017 Jan 15. PMID: 28243328
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Survivin Down-Regulation
[+]

Beta-phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38.Jun 30, 2012

Pubmed Data : Oral Dis. 2012 Jul ;18(5):513-9. Epub 2012 Feb 6. PMID: 22309674
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Beta-Phenethyl isothiocyanate is a promising compound for potential use in leukemia treatment.Dec 14, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2011 Dec 15 ;15(12):2911-21. Epub 2011 Sep 29. PMID: 21827296
Article Published Date : Dec 14, 2011
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antineoplastic Agents
[+]

Beta-phenethyl isothiocyanate promotes neurite growth in primary sensory neurons.Dec 31, 2018

Pubmed Data : J Drug Target. 2019 Jan ;27(1):82-93. Epub 2018 Sep 5. PMID: 29877111
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : MicroRNA modulator, Neuritogenic
[+]

Beta-phenylethyl isothiocyanate and curcumin work synergistically to inhibit prostate cancer cell signaling.Aug 01, 2006

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31. PMID: 16299382
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa seed extract.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(8):e0182658. Epub 2017 Aug 8. PMID: 28792522
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera, Turmeric
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas.Aug 03, 2018

Pubmed Data : Med Oncol. 2018 Aug 4 ;35(9):124. Epub 2018 Aug 4. PMID: 30078069
Article Published Date : Aug 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Head and Neck Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Broccoli sprouts are an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.Sep 16, 1997

Pubmed Data : Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72. PMID: 9294217
Article Published Date : Sep 16, 1997
Study Type : In Vitro Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Broccoli sprouts contains phytochemicals like sulforaphane which have anti-Helicobacter pylori activity.Jun 01, 2009

Pubmed Data : J Med Food. 2009 Jun;12(3):518-27. PMID: 20459098
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Plant Extracts
[+]

Chemicals from the diet can influence the expression of functionally important long noncoding RNAs.Jan 11, 2017

Pubmed Data : J Nutr Biochem. 2017 Jan 12 ;42:72-83. Epub 2017 Jan 12. PMID: 28131897
Article Published Date : Jan 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive, MicroRNA modulator
Additional Keywords : Gene Expression Regulation
[+]

Chemopreventive and antitumor effects of benzyl isothiocynate on liver cancer.Sep 10, 2018

Pubmed Data : Biomed Pharmacother. 2018 Sep 11 ;108:65-75. Epub 2018 Sep 11. PMID: 30216802
Article Published Date : Sep 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Chemopreventive, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone.Feb 26, 2019

Pubmed Data : Cancer. 2019 Feb 27. Epub 2019 Feb 27. PMID: 30811596
Article Published Date : Feb 26, 2019
Study Type : Review
Additional Links
Substances : Piperine, Sulforaphane, Thymoquinone
Diseases : Cancers: All
Pharmacological Actions : Chemotherapeutic
[+]

Combination of photodynamic therapy and Sulforaphane led to enhanced cytotoxic effect on head and neck cancer cells.Dec 31, 2014

Pubmed Data : Gen Physiol Biophys. 2015 Jan ;34(1):13-21. Epub 2014 Nov 14. PMID: 25395599
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Head and Neck Cancer
Therapeutic Actions : Photodynamic therapy
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cytotoxic
[+]

Combination treatment with resveratrol and sulforaphane induces programmed cell death in human glioma cells.Jan 01, 2010

Pubmed Data : Neurochem Res. 2010 Jan;35(1):152-61. Epub 2009 Aug 15. PMID: 19685289
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Sulforaphane
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Stilbenes
[+]

Combined Sulforaphane and selenium treatment resulted in a synergistic up-regulation of TrxR-1 that in part contributed to the enhanced protection against free radical-mediated cell death. May 29, 2015

Pubmed Data : Nutr Res. 2015 May 30. Epub 2015 May 30. PMID: 26094214
Article Published Date : May 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Selenium, Sulforaphane
Diseases : Colon Cancer: Prevention, Oxidative Stress
Pharmacological Actions : Antioxidants, NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords : Natural Substance Synergy
[+]

Combined treatment induced apoptosis more efficiently than either agent alone; however the most effective was a combination of lapatinib with erucin.Jul 01, 2015

Pubmed Data : Nutr Cancer. 2015 Jul 2:1-11. Epub 2015 Jul 2. PMID: 26134366
Article Published Date : Jul 01, 2015
Study Type : In Vitro Study
Additional Links
Substances : Erucin, Sulforaphane
Diseases : Breast Cancer: HER-2 Overexpressed
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Drug: Allopurinol, Isothiocyanates, Natural Substance/Drug Synergy
[+]

Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome.Feb 06, 2018

Pubmed Data : Free Radic Biol Med. 2018 Feb 7. Epub 2018 Feb 7. PMID: 29427794
Article Published Date : Feb 06, 2018
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cardiovascular Diseases, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, NF-E2-Related Factor-2 (Nrf2) Modulator, NF-kappaB Inhibitor
[+]

Cruciferous vegetables are antioxidative, chemopreventive and antineoplasic functional foods against prostate cancers.Jan 15, 2019

Pubmed Data : Curr Pharm Des. 2019 Jan 16. Epub 2019 Jan 16. PMID: 30652644
Article Published Date : Jan 15, 2019
Study Type : Review
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Cyclin D1 is an important determinant of the therapeutic efficiency of Sulforaphane in A549 cells.May 31, 2016

Pubmed Data : Int J Oncol. 2016 Jun ;48(6):2521-33. Epub 2016 Mar 18. PMID: 27035641
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, P21 Activation
[+]

Dietary isothiocyanates have beneficial roles in the prevention of chronic illnesses such as cancer, inflammatory diseases and immune disorders.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(6):e0157430. Epub 2016 Jun 15. PMID: 27304884
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Dietary sulforaphane is a histone deacetylase inhibitor for cancer prevention.Dec 01, 2009

Pubmed Data : J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. PMID: 19812222
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Experimental data supports the bright future of natural polyphenols as anticancer tools.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:6475624. Epub 2015 Nov 16. PMID: 26649142
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Genistein, Polyphenols, Resveratrol, Sulforaphane
Diseases : Cancers: All, Oxidative Stress
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Chemopreventive
Additional Keywords : Epigenetic Modification In Cancer
[+]

Growing evidence shows that vitamins, minerals, and other dietary factors have profound and protective effects against cancer cells, whether they are grown in the lab, in animals, or studied in human populations. Apr 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Semin Cancer Biol. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25869442
Article Published Date : Apr 09, 2015
Study Type : Review
Additional Links
Substances : Carotenoids, Isothiocyanates, Polyphenols, Resveratrol, Selenium, Vitamin D
Diseases : Cancers: All, DNA damage
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Genomic Instability, Natural Substance Synergy
[+]

HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.Apr 05, 2018

Pubmed Data : Int J Cancer. 2018 Apr 6. Epub 2018 Apr 6. PMID: 29633255
Article Published Date : Apr 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Histone deacetylase inhibitor
[+]

In this review, they discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2015 Jun 1 ;22(16):1382-424. Epub 2014 Dec 19. PMID: 25364882
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, Histone deacetylase inhibitor, NF-kappaB Inhibitor, Phase II Detoxification Enzyme Inducer
Additional Keywords : Dietary Concentrations, Selective Cytotoxicity
[+]

In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis.Apr 30, 2015

Pubmed Data : Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID: 26457242
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol, Phenethyl isothiocyanate, Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive, MicroRNA modulator, Nrf2 activation
Additional Keywords : DNA Methylation
[+]

Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate in lung cancer cells.Dec 25, 2017

Pubmed Data : Mol Carcinog. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29278657
Article Published Date : Dec 25, 2017
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Autophagy Up-regulation
[+]

Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation.Apr 09, 2018

Pubmed Data : Nucleosides Nucleotides Nucleic Acids. 2018 Apr 10:1-10. Epub 2018 Apr 10. PMID: 29634384
Article Published Date : Apr 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Epigenetic Modification In Cancer, Natural Substance/Drug Synergy, Reactivation Of Tumor Suppressor Gene
[+]

Inhibition of glycolysis in prostate cancer chemoprevention by phenethyl isothiocyanate.Mar 14, 2018

Pubmed Data : Cancer Prev Res (Phila). 2018 Mar 15. Epub 2018 Mar 15. PMID: 29545400
Article Published Date : Mar 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
[+]

Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mitochondrion. 2016 09 ;30:67-77. Epub 2016 Jun 30. PMID: 27374852
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells.Jan 08, 2017

Pubmed Data : Biochem Biophys Res Commun. 2017 09 9 ;491(1):209-216. Epub 2017 Jul 13. PMID: 28712871
Article Published Date : Jan 08, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Cancers: Drug Resistant, Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative
Additional Keywords : Isothiocyanates
[+]

Isothiocyanates could be potential agents for the prevention of C6 glioma cell migration and invasion.Sep 17, 2015

Pubmed Data : Oncol Rep. 2015 Sep 18. Epub 2015 Sep 18. PMID: 26397194
Article Published Date : Sep 17, 2015
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Sulforaphane
Diseases : Glioma
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Isothiocyanates suppress the invasion and metastasis of tumors.Sep 07, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 8 ;8(38):63949-63962. Epub 2017 Jul 12. PMID: 28969043
Article Published Date : Sep 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Low isothiocyanate concentrations exerts an anti-cancer effect specific to human malignant melanoma cells.Jan 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2016 12 ;36(12):6303-6309. PMID: 27919950
Article Published Date : Jan 11, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Malignant Melanoma
Pharmacological Actions : Apoptotic
[+]

Lyophilized broccoli sprouts may be effectively used in dietary chemoprevention.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plant Foods Hum Nutr. 2018 Jun ;73(2):95-100. PMID: 29675806
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Isothiocyanates, Sulforaphane
Diseases : Colon Cancer, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive
[+]

Many dietary phytochemicals are shown to modify and reverse aberrant epigenetic changes, potentially leading to cancer prevention or treatment.Dec 18, 2016

Pubmed Data : Chem Res Toxicol. 2016 Dec 19 ;29(12):2071-2095. Epub 2016 Dec 5. PMID: 27989132
Article Published Date : Dec 18, 2016
Study Type : Review
Additional Links
Substances : Isothiocyanates, Polyphenols
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive, Nrf2 activation
Additional Keywords : Epigenetic Modification In Cancer
[+]

Moringa isothiocyanate has a potential role in diabetic nephropathy.Feb 18, 2019

Pubmed Data : AAPS J. 2019 Feb 19 ;21(2):31. Epub 2019 Feb 19. PMID: 30783799
Article Published Date : Feb 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Natural isothiocyanates represent a promising group of natural anti-infective compounds with activity against Pseudomonas aeruginosa biofilms.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Fitoterapia. 2017 Jun ;119:57-63. Epub 2017 Apr 5. PMID: 28390975
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Horseradish, Isothiocyanates
Diseases : Pseudomonas aeruginosa
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Anti-Bacterial Agents, Biofilm, Horseradish, Isothiocyanates, Pseudomonas aeruginosa
[+]

Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes.Nov 04, 2015

Pubmed Data : Cancer Res. 2015 Nov 5. Epub 2015 Nov 5. PMID: 26542215
Article Published Date : Nov 04, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Cancers: All
Pharmacological Actions : anti-inflammatory, Chemopreventive, DNA Repair Up-regulation, Enzyme Inhibitors
[+]

Noni contains an anthraquinone with potent quinone reductase-inducing (i.e. detoxifying) activity 40 times more potent than sufloraphane.Dec 01, 2010

Pubmed Data : Rejuvenation Res. 2010 Dec;13(6):749-54. PMID: 16378361
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Noni, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents, Quinone Reductase-Inducer
[+]

Nrf2 targeting by Sulforaphane could be a potential therapy for cancer treatment.Dec 20, 2016

Pubmed Data : Crit Rev Food Sci Nutr. 2016 Dec 21:0. Epub 2016 Dec 21. PMID: 28001083
Article Published Date : Dec 20, 2016
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Nrf2 activation
[+]

Numerous nutrients and non-nutrient dietary bioactive components can reduce the occurrence and delay the development of liver cancer. Jun 07, 2016

Pubmed Data : Nutr Cancer. 2016 Jun 8:1-15. Epub 2016 Jun 8. PMID: 27266713
Article Published Date : Jun 07, 2016
Study Type : Review
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Resveratrol, Sulforaphane
Diseases : Liver Cancer, Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Epigenetic Modification In Cancer
[+]

Phenethyl isothiocyanate activates leptin signaling and decreases food intake.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0206748. Epub 2018 Nov 1. PMID: 30383868
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Obesity
Pharmacological Actions : Appetite Suppresant
Additional Keywords : Anti-Obesity Agents
[+]

Phenethyl isothiocyanate and Benzyl isothiocyanate inhibit human melanoma A375.S2 cell migration and invasion.Jan 10, 2017

Pubmed Data : Anticancer Res. 2017 11 ;37(11):6223-6234. PMID: 29061805
Article Published Date : Jan 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate and cisplatin co-encapsulated in a liposomal nanoparticle for treatment of non-small cell lung cancer.Feb 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Feb 22 ;24(4). Epub 2019 Feb 22. PMID: 30813352
Article Published Date : Feb 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane have a synergistic effect in the inhibition of inflammation.Jan 01, 2009

Pubmed Data : Pharm Res. 2009 Jan;26(1):224-31. Epub 2008 Oct 8. PMID: 18841446
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate, Sulforaphane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Phenethyl isothiocyanate and ursolic acid protects DNA from oxidative damage.Jan 29, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Jan 30. Epub 2018 Jan 30. PMID: 29383876
Article Published Date : Jan 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : DNA damage
Pharmacological Actions : Genoprotective
[+]

Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells.Apr 24, 2018

Pubmed Data : Food Funct. 2018 Apr 25 ;9(4):2398-2408. PMID: 29595853
Article Published Date : Apr 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Dibenzoylmethane (DBM), Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor, Survivin Down-Regulation
[+]

Phenethyl isothiocyanate induces apoptotic cell death in gefitinib-resistant NCI-H460 human lung cancer cells.Dec 31, 2017

Pubmed Data : Anticancer Res. 2018 04 ;38(4):2137-2147. PMID: 29599332
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.Nov 30, 2018

Pubmed Data : Phytother Res. 2018 Dec ;32(12):2447-2455. Epub 2018 Aug 30. PMID: 30159926
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer.Dec 15, 2016

Pubmed Data : Cancer Biol Ther. 2016 Dec 16:1-10. Epub 2016 Dec 16. PMID: 27981892
Article Published Date : Dec 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Phenethyl isothiocyanate
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-metastatic
[+]

Phytochemicals may serve as novel therapeutic agents for breast cancer treatment.Sep 30, 2016

Pubmed Data : Semin Cancer Biol. 2016 Oct ;40-41:192-208. Epub 2016 Sep 5. PMID: 27609747
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : 6-Shogaol, Celastrol, Curcumin, EGCG (Epigallocatechin gallate), Epicatechin, Genistein, Indole-3-Carbinol, Isoliquiritigenin, Parthenolide, Pterostilbene, Quercetin, Resveratrol, Sulforaphane, Triptolide, Vitamin E
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Cancer Stem Cells
[+]

Phytochemicals which inhibit cancer stem cells may prove to be promising agents for the prevention and treatment of pancreatic cancers.Jan 25, 2017

Pubmed Data : Curr Med Chem. 2017 Jan 26. Epub 2017 Jan 26. PMID: 28137215
Article Published Date : Jan 25, 2017
Study Type : Review
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Genistein, Indole-3-Carbinol, Quercetin, Resveratrol, Sulforaphane, Vitamin E: delta-tocopherol
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

Polyphenol antioxidants have properties to treat neurodegenerative diseases.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Neurosci. 2016 Apr ;7(2):81-90. PMID: 27303602
Article Published Date : Mar 31, 2016
Study Type : Review
Additional Links
Substances : Allicin, Carnosic Acid, Curcumin, EGCG (Epigallocatechin gallate), Isothiocyanate, Quercetin, Resveratrol, Rosmarinic acid, Sulforaphane
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Potential efficacy of sulforaphane and probably other bioactive components of young broccoli sprouts make it as an excellent choice for supplementary treatment in type 2 diabetes.Apr 30, 2013

Pubmed Data : J Med Food. 2013 May ;16(5):375-82. Epub 2013 Apr 30. PMID: 23631497
Article Published Date : Apr 30, 2013
Study Type : Review
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Diabetic Nephropathy, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-E2-Related Factor-2 (Nrf2) Modulator, NF-kappaB Inhibitor
[+]

Pre-treatment with sulforaphane completely restored the antioxidant status and prevented inflammatory responses mediated by acrolein.Jul 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Med Sci. 2016 Aug 1 ;12(4):871-80. Epub 2016 Jul 1. PMID: 27478470
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Nrf2 activation
[+]

Radioprotection by repeated sulforaphane treatment was dose-dependent with an optimal effect at 10 uM, whereas both lower and higher concentrations resulted in lower levels of radioprotection.Apr 30, 2014

Pubmed Data : Toxicol Appl Pharmacol. 2014 May 1 ;276(3):188-94. Epub 2014 Mar 3. PMID: 24603300
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Sulforaphane
Diseases : DNA damage
Pharmacological Actions : Nrf2 activation, Radioprotective
Additional Keywords : Dose Response, Ionizing Radiation
[+]

Sufloraphane reduces doxorubicin resistance.Oct 10, 2006

Pubmed Data : Mutat Res. 2006 Oct 10;601(1-2):92-101. Epub 2006 Jul 14. PMID: 16843502
Article Published Date : Oct 10, 2006
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cancers: Drug Resistant
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Drug: Doxorubicin, Drug-Plant-Vitamin Synergies
[+]

Sulforaphane activates DNA methylation of silenced tumour suppressor genes in breast cancer cells and may contribute to SFN-mediated support of therapy with an anti-cancer drug.Sep 15, 2015

Pubmed Data : J Nutrigenet Nutrigenomics. 2015 Sep 16 ;8(2):91-101. Epub 2015 Sep 16. PMID: 26372775
Article Published Date : Sep 15, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : DNA Methylation, Natural Substance/Drug Synergy, Reactivation Of Tumor Suppressor Gene
[+]

Sulforaphane activates progammed cell death in human glioblastoma cells. Sep 01, 2006

Pubmed Data : Neuroscience. 2006 Sep 1;141(3):1265-80. Epub 2006 Jun 12. PMID: 16765523
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Cancer, Glioblastoma
Pharmacological Actions : Apoptotic
[+]

Sulforaphane activates programmed cell death pathways in human colon cancer cells.Sep 01, 2009

Pubmed Data : Food Chem Toxicol. 2009 Sep;47(9):2366-73. Epub 2009 Jun 27. PMID: 19563859
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, DNA damage, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Sulforaphane and 5-fluorouracil act synergistically in the MDA-MB-231 cells.Nov 01, 2017

Pubmed Data : Food Chem Toxicol. 2017 Nov 2 ;111:1-8. Epub 2017 Nov 2. PMID: 29104175
Article Published Date : Nov 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Sulforaphane and alpha-lipoic acid upregulate the expression of the phase 2 liver detoxification enzyme glutathione S-transferase.Mar 01, 2010

Pubmed Data : J Nutr Health Aging. 2010 Mar;14(3):219-23. PMID: 20237067
Article Published Date : Mar 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid, Garlic, Sulforaphane
Diseases : Glutathione Deficiency
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Sulforaphane and benzyl isothiocyanate exhibit antibacterial activity against gram-positive and gram-negative bacteria.Jun 01, 2009

Pubmed Data : J Appl Microbiol. 2009 Jun;106(6):2086-95. Epub 2009 Mar 9. PMID: 19291240
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Bacterial Infections and Mycoses, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Sulforaphane and epigallocatechin-3-gallate (EGCG) can positively modulate the epigenome and lead to many health benefits.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Biol. 2015 Jan 1 ;218(Pt 1):59-70. PMID: 25568452
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification, Histone Modifications
[+]

Sulforaphane and its metabolite mediate growth arrest and programmed cell death in human prostate cancer cells.Mar 01, 2002

Pubmed Data : Int J Oncol. 2002 Mar;20(3):631-6. PMID: 11836580
Article Published Date : Mar 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane attenuated the pro-inflammatory state induced by hydrogen peroxide in SH-SY5Y cells.Feb 22, 2018

Pubmed Data : Neurotox Res. 2018 Feb 23. Epub 2018 Feb 23. PMID: 29473125
Article Published Date : Feb 22, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-κB.Apr 30, 2014

Pubmed Data : Herz. 2014 May ;39(3):390-6. Epub 2013 Jun 21. PMID: 23784363
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Sulforaphane attenuates pulmonary fibrosis by inhibiting the epithelial-mesenchymal transition.Apr 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Pharmacol Toxicol. 2018 Apr 2 ;19(1):13. Epub 2018 Apr 2. PMID: 29609658
Article Published Date : Apr 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Sulforaphane can be used as an effective adjunct for the prevention of renal oxidative insults during ischemia-reperfusion injury.Jun 01, 2008

Pubmed Data : Biochem Pharmacol. 2008 Jun 1;75(11):2214-23. Epub 2008 Mar 4. PMID: 18407246
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Kidney Damage
Pharmacological Actions : Apoptotic, Phase II Detoxification Enzyme Inducer, Renoprotective
[+]

Sulforaphane can be used for the management of TRAIL-resistant cancer.May 20, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2018 May 21. Epub 2018 May 21. PMID: 29792947
Article Published Date : May 20, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Chemotherapeutic, Nrf2 activation
[+]

Sulforaphane can increase the antimicrobial peptide secretion of beta-defensin 2 in intestinal cells.Oct 01, 2008

Pubmed Data : Immunology. 2008 Oct;125(2):241-51. Epub 2008 Mar 27. PMID: 18373608
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gastrointestinal Diseases, Immune Disorders: Low Immune Function, Intestinal Diseases, Low Disorders: Low TH1
Pharmacological Actions : Beta-Defensin-2 Up-Regulation, Enzyme Inhibitors, Histone deacetylase inhibitor, NF-kappaB Inhibitor
[+]

Sulforaphane content of various cruciferous vegetables.Sep 01, 2006

Pubmed Data : Pediatr Dermatol. 2006 Sep-Oct;23(5):484-7. PMID: 19480351
Article Published Date : Sep 01, 2006
Study Type : Commentary
Additional Links
Substances : Broccoli, Cabbage, Cruciferous, Cruciferous Vegetables, Red Cabbage, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
[+]

Sulforaphane could be considered as a potential adjuvant therapeutic agent in treating glioblastoma patients combined with temozolomide.May 19, 2015

Pubmed Data : J Neurochem. 2015 May 20. Epub 2015 May 20. PMID: 25991372
Article Published Date : May 19, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Chemopreventive, Chemotherapeutic, MicroRNA modulator, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Sulforaphane could reduce cancer stem cell survival and tumor formation.Sep 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 26 ;8(43):73407-73418. Epub 2017 Aug 27. PMID: 29088716
Article Published Date : Sep 25, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Cancer
Pharmacological Actions : Chemopreventive, Chemotherapeutic
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane demonstrates antivasculogenic/antiangiogenic activity that may have a role in cancer treatment.Jan 01, 2009

Pubmed Data : Hear Res. 2009 Jan;247(2):137-45. Epub 2008 Dec 3. PMID: 19034579
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis
Pharmacological Actions : Anti-Angiogenic, Anticarcinogenic Agents, Apoptotic
[+]

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.Sep 29, 2009

Pubmed Data : Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16663-8. Epub 2009 Sep 15. PMID: 19805354
Article Published Date : Sep 29, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Androgen-Induced Diseases, Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Histone deacetylase inhibitor
[+]

Sulforaphane diminishes arsenic toxicity through reducing cellular arsenic levels.Mar 20, 2006

Pubmed Data : FEBS Lett. 2006 Mar 20;580(7):1771-4. Epub 2006 Feb 24. PMID: 16516206
Article Published Date : Mar 20, 2006
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Arsenic Poisoning, Chemically-Induced Liver Damage
Pharmacological Actions : Detoxifier
[+]

Sulforaphane down-regulates COX-2 (inflammatory enzyme) expression in human bladder cells, indicating its value as a chemopreventive agent.Apr 01, 2009

Pubmed Data : Int J Oncol. 2009 Apr;34(4):1129-34. PMID: 19287971
Article Published Date : Apr 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Sulforaphane enhances radiosensitivity in human tumor cells.Jul 01, 1978

Pubmed Data : Antibiotiki. 1978 Jul;23(7):633-6. PMID: 19452523
Article Published Date : Jul 01, 1978
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cervical Cancer, Tumors
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Radiopharmaceuticals
[+]

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.Feb 26, 2017

Pubmed Data : Cancer Lett. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28254410
Article Published Date : Feb 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Docetaxel
[+]

Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression.Feb 08, 2018

Pubmed Data : J Nutr Biochem. 2018 Feb 9 ;56:109-115. Epub 2018 Feb 9. PMID: 29525530
Article Published Date : Feb 08, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer
Pharmacological Actions : MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

Sulforaphane exerted a concentration-dependent inhibitory effect on the inflammatory cytokine production by the immune cells.Mar 06, 2018

Pubmed Data : Int J Food Sci Nutr. 2018 Mar 7:1-8. Epub 2018 Mar 7. PMID: 29513123
Article Published Date : Mar 06, 2018
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, Immunomodulatory
[+]

Sulforaphane exerts an anti-neuroinflammatory effect on microglia through JNK/AP-1/NF-κB pathway inhibition and Nrf2/HO-1 pathway activation.Feb 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2019 Feb 22 ;8(2). Epub 2019 Feb 22. PMID: 30813369
Article Published Date : Feb 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane exerts protective effects on microglia and modulates the microglial activation state.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:36. Epub 2018 Jan 23. PMID: 29410668
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane exhibits activity against metastatic melanoma cells. Jul 01, 2011

Pubmed Data : Drug Chem Toxicol. 2011 Jul ;34(3):332-40. PMID: 21649489
Article Published Date : Jul 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Sulforaphane exhibits anti-breast cancer properties. Sep 01, 2011

Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865
Article Published Date : Sep 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Metastatic, Cancer Metastasis
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Sulforaphane exhibits anti-cancer activity against liver cancer cells.Sep 28, 2010

Pubmed Data : Cancer Lett. 2010 Sep 28;295(2):260-6. Epub 2010 May 6. PMID: 20451318
Article Published Date : Sep 28, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic
[+]

Sulforaphane exhibits anti-carcinogenic activity against cervical cancer. Oct 16, 2010

Pubmed Data : Cancer Epidemiol. 2010 Oct 16. Epub 2010 Oct 16. PMID: 20956097
Article Published Date : Oct 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Drug: Gemcitabine, Drug-Plant-Vitamin Synergies
[+]

Sulforaphane exhibits anti-tumor, antibacterial and antifungal activities.Jun 01, 2008

Pubmed Data : Planta Med. 2008 Jun;74(7):747-50. Epub 2008 May 16. PMID: 18484523
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Broccoli, Cruciferous Vegetables, Sulforaphane
Diseases : Bacterial Infections and Mycoses, Fungal Infection, Tumors
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents
[+]

Sulforaphane exhibits antiproliferative activity in Akt-overexpressing ovarian cancer cells.Jan 01, 2007

Pubmed Data : Mol Cancer Ther. 2007 Jan;6(1):334-45. PMID: 17237292
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Ovarian Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane exhibits antiproliferative effects against a human colon cancer cell line.Aug 01, 2007

Pubmed Data : Mol Nutr Food Res. 2007 Aug;51(8):977-84. PMID: 17628879
Article Published Date : Aug 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane exhibits antiproliferative effects in a human colon cancer cell line.Jan 01, 2007

Pubmed Data : Acta Medica (Hradec Kralove). 2007;50(3):171-6. PMID: 18254269
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
[+]

Sulforaphane exhibits chemopreventive properties through the stimulation of detoxifying enzymes.Aug 19, 2010

Pubmed Data : Int J Cancer. 2010 Aug 19. Epub 2010 Aug 19. PMID: 20726001
Article Published Date : Aug 19, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Detoxifier
[+]

Sulforaphane found within broccoli sprouts has gastroprotective and chemopreventive properties.Jan 01, 2011

Pubmed Data : Curr Pharm Des. 2011 ;17(16):1532-40. PMID: 21548875
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Gastric Cancer, Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Chemopreventive
[+]

Sulforaphane has a chemopreventive effect in colon cancer cells. Apr 30, 2012

Pubmed Data : Chin J Physiol. 2012 Apr 30 ;55(2):134-44. PMID: 22559738
Article Published Date : Apr 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive
[+]

Sulforaphane has a potential use as a compound for protection against UVB-induced skin inflammation.Aug 01, 2010

Pubmed Data : J Nutr Biochem. 2010 Aug;21(8):702-9. Epub 2009 Jul 2. PMID: 19576749
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Diseases: Photo-Aging, Sunburn, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Sulforaphane has a protective effect against DNA damage caused by low levels of pesticides.Sep 01, 2009

Pubmed Data : J Environ Sci Health B. 2009 Sep;44(7):657-62. PMID: 20183075
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : DNA damage, Pesticide Toxicity
[+]

Sulforaphane has a protective effect against dopaminergic cell death.Apr 01, 2007

Pubmed Data : J Pharmacol Exp Ther. 2007 Apr;321(1):249-56. Epub 2007 Jan 26. PMID: 17259450
Article Published Date : Apr 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Dopamine Deficiency, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Sulforaphane has been found to scavenge hydrogen peroxide, efficiently converting it into water. May 27, 2015

Pubmed Data : J Phys Chem B. 2015 May 28. Epub 2015 May 28. PMID: 26020652
Article Published Date : May 27, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants
[+]

Sulforaphane has potent apoptosis inducing effects and invasion inhibiting effects against U251 glioblastoma cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Springerplus. 2016 ;5:235. Epub 2016 Feb 29. PMID: 27026929
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions :