Isothiocyanates

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60 Diseases Researched for Isothiocyanates
NameACCKFocus
Lung Cancer524Locked
Breast Cancer820Locked
Lung Cancer: Prevention220Locked
Autism Spectrum Disorders110Locked
Cancers: All1010Locked
High Cholesterol110Locked
Osteoarthritis: Knee110Locked
Oxidative Stress110Locked
Smoking110Locked
Inflammation58Locked
Bladder Cancer66Locked
Liver Cancer55Locked
Obesity45Locked
Breast Cancer: Chemically-Induced24Locked
Colitis24Locked
High Fat Diet24Locked
Ovarian Cancer34Locked
Prostate Cancer34Locked
Cancer Metastasis33Locked
Insulin Resistance23Locked
Oral Cancer23Locked
Alcohol Toxicity 12Locked
Atherosclerosis12Locked
Brain Inflammation 22Locked
Brain: Oxidative Stress12Locked
Chemically-Induced Liver Damage12Locked
Colon Cancer22Locked
Colorectal Cancer22Locked
DNA damage22Locked
Diabetes Mellitus: Type 212Locked
Diabetes: Oxidative Stress12Locked
Esophageal Cancer12Locked
Gastric Ulcer12Locked
Glioma22Locked
Inflammatory Bowel Diseases12Locked
Lipopolysaccharide-Induced Toxicity12Locked
Liver Cirrhosis12Locked
Liver Fibrosis12Locked
Malignant Melanoma22Locked
Nonalcoholic fatty liver disease (NAFLD)12Locked
Rheumatoid Arthritis12Locked
Sepsis12Locked
Traumatic Brain Injury12Locked
Ulcerative Colitis12Locked
Breast Cancer: Triple Negative 11Locked
Candida Albicans11Locked
Cervical Cancer11Locked
Chronic Obstructive Pulmonary Disease11Locked
Diabetic Nephropathy11Locked
Escherichia coli Infections11Locked
Foodborne Pathogens: Prevention/Food Preservation11Locked
Kidney Cancer11Locked
Leukemia11Locked
Leukemia: Chronic myelogenous leukemia (CML) 11Locked
Neuroblastoma11Locked
Pancreatic Cancer11Locked
Promyelocytic leukemia 11Locked
Pseudomonas aeruginosa11Locked
Sciatic Nerve Crush Injury11Locked
Thyroid Cancer11Locked
55 Pharmacological Actions Researched for Isothiocyanates
NameACCKFocus
Chemopreventive1838Locked
Anti-Inflammatory Agents1531Locked
Anticarcinogenic Agents1025Locked
Antiproliferative 2225Locked
Apoptotic2023Locked
Nrf2 activation1023Locked
Antioxidants1220Locked
Hypolipidemic314Locked
Neuroprotective Agents414Locked
NF-kappaB Inhibitor812Locked
Chondroprotective110Locked
Cytoprotective110Locked
Glutathione S-transferase Inhibitor110Locked
Interleukin-6 Downregulation610Locked
Cell cycle arrest99Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor59Locked
Anti-metastatic78Locked
Antineoplastic Agents45Locked
Chemotherapeutic55Locked
Interleukin-1 beta downregulation35Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor55Locked
Tumor Suppressor Protein p53 Upregulation35Locked
Gastrointestinal Agents24Locked
Hepatoprotective24Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor44Locked
Chemosensitizer23Locked
Cyclooxygenase 2 Inhibitors23Locked
Heme oxygenase-1 up-regulation23Locked
Angiogenesis Inhibitors12Locked
Anti-Bacterial Agents22Locked
Anti-Estrogenic12Locked
Anti-Fibrotic12Locked
Antifungal Agents22Locked
Autophagy Up-regulation22Locked
Bcl-2 protein down-regulation22Locked
Gastroprotective12Locked
Interferon Gamma Reducer12Locked
Malondialdehyde Down-regulation12Locked
MicroRNA modulator22Locked
Nitric Oxide Inhibitor12Locked
Superoxide Dismutase Up-regulation12Locked
Vascular Endothelial Growth Factor A Inhibitor12Locked
Anti-Adipogenic11Locked
Antimutagenic Agents11Locked
DNA Repair Up-regulation11Locked
Enzyme Inhibitors11Locked
Histone deacetylase inhibitor11Locked
Immunomodulatory11Locked
Insulin Sensitizers11Locked
NF-E2-Related Factor-2 (Nrf2) Modulator11Locked
Neuritogenic11Locked
Prostaglandin PGE2 downregulation11Locked
Radioprotective11Locked
Radiosensitizer11Locked
anti-inflammatory11Locked
Related Topics

The Following are Sub-Topics of Isothiocyanates

View the Evidence:
596 Abstracts with Isothiocyanates Research

[+]

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973
Article Published Date : Oct 17, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Epigenetic Modification In Cancer
[+]

After 4 weeks consuming broccoli sprouts powder it resulted in a significant decrease in serum insulin concentration in patients. Oct 31, 2012

Pubmed Data : Int J Food Sci Nutr. 2012 Nov ;63(7):767-71. Epub 2012 Apr 26. PMID: 22537070
Article Published Date : Oct 31, 2012
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Hyperinsulinism, Insulin Resistance
Pharmacological Actions : Antioxidants, Insulin Down-Regulation
[+]

Broccoli sprout homogenate is safe in stable SCD patients and may induce changes in gene expression levels.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(4):e0152895. Epub 2016 Apr 12. PMID: 27071063
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Anemia: Sickle Cell
Additional Keywords : Gene Expression Regulation
[+]

Broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.Dec 31, 2011

Pubmed Data : Carcinogenesis. 2012 Jan ;33(1):101-7. Epub 2011 Nov 1. PMID: 22045030
Article Published Date : Dec 31, 2011
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Air Pollution Linked Toxicity, DNA damage
Additional Keywords : Isothiocyanates
[+]

Broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Apr 01, 2009

Pubmed Data : Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60. PMID: 19349290
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Substances : Broccoli, Broccoli Sprouts, Sprouts, Sulforaphane
Diseases : Gastritis, Helicobacter Pylori Infection
[+]

Consumption of a diet rich in cruciferous vegetables may reduce the risk of lung cancer among smokers.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2010 ;10:162. Epub 2010 Apr 27. PMID: 20423504
Article Published Date : Dec 31, 2009
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Lung Cancer, Lung Cancer: Prevention, Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Risk Reduction
[+]

Consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions.Apr 14, 2015

Pubmed Data : Food Chem. 2015 Apr 15 ;173:1187-94. Epub 2014 Nov 7. PMID: 25466142
Article Published Date : Apr 14, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Cruciferous vegetable intake may be associated with a reduction in lung cancer risk among men who are currently nonsmokers.Apr 04, 2017

Pubmed Data : J Nutr. 2017 Apr 5. Epub 2017 Apr 5. PMID: 28381528
Article Published Date : Apr 04, 2017
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Chemopreventive
[+]

Daily administration of free sulforaphane shows promise in managing biochemical recurrences in prostate cancer after radical prostatectomy.May 11, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2015 May 12. Epub 2015 May 12. PMID: 25968598
Article Published Date : May 11, 2015
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate: PSA Doubling, Radical Prostatectomy
Additional Keywords : Recurrence Risk, Significant Treatment Outcome
[+]

Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients.Apr 23, 2018

Pubmed Data : Cancer Prev Res (Phila). 2018 Apr 24. Epub 2018 Apr 24. PMID: 29691233
Article Published Date : Apr 23, 2018
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive
[+]

Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2015 May ;59(5):918-26. Epub 2015 Apr 7. PMID: 25851421
Article Published Date : Apr 30, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli, Isothiocyanates
Diseases : High Cholesterol
Pharmacological Actions : Hypolipidemic
[+]

Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Autism. 2018 ;9:35. Epub 2018 May 30. PMID: 29854372
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism Spectrum Disorders
Pharmacological Actions : Antioxidants
[+]

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.Jan 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 06 13 ;7(1):3398. Epub 2017 Jun 13. PMID: 28611391
Article Published Date : Jan 12, 2017
Study Type : Human Study
Additional Links
Substances : Broccoli, Isothiocyanates
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Chondroprotective
[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli.Nov 26, 2008

Pubmed Data : J Agric Food Chem. 2008 Nov 26;56(22):10505-9. PMID: 18950181
Article Published Date : Nov 26, 2008
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Raw versus Cooked
[+]

Safety Study: Brocolli sprouts (sulforaphane) are safe, tolerable and do not adversely effect thyroid hormone levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;55(1):53-62. PMID: 16965241
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Sulforaphane as an adjunctive treatment for irritability in children with autism spectrum disorder.Apr 28, 2020

Pubmed Data : Psychiatry Clin Neurosci. 2020 Apr 29. Epub 2020 Apr 29. PMID: 32347624
Article Published Date : Apr 28, 2020
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism Spectrum Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane detoxifies benzene, an air pollutant, in a dose-dependent manner and may attentuate attenuate associated long-term health risks of air pollution. Jul 03, 2019

Pubmed Data : Am J Clin Nutr. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31268126
Article Published Date : Jul 03, 2019
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Air Pollution Linked Toxicity, Benzene Toxicity
Pharmacological Actions : Antioxidant Effects, Detoxifier
Additional Keywords : Airborne Pollution, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Dose Response, Environmental Pollutant, Environmental Pollution
Problem Substances : Airborne Pollution, Benzene
[+]

Sulforaphane from broccoli was able to reduce some of the symptoms of autism.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Glob Adv Health Med. 2017 ;6:2164957X17735826. Epub 2017 Oct 26. PMID: 29147630
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Autism
[+]

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Chemopreventive, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Sulforaphane protects against chemically-induced damage in bladder cells and tissues. Jan 01, 2003

Pubmed Data : Phytother Res. 2003 Jan;17(1):66-9. PMID: 20810543
Article Published Date : Jan 01, 2003
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer, Bladder Degeneration, DNA damage
Pharmacological Actions : Chemopreventive, Genoprotective
[+]

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Respir Res. 2015 ;16:106. Epub 2015 Sep 15. PMID: 26369337
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Asthma, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID: 17416783
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Skin Diseases
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.Dec 31, 2013

Pubmed Data : Food Funct. 2014 Jan ;5(1):35-41. PMID: 24287881
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diesel Exhaust Particle Toxicity
Pharmacological Actions : Anti-Allergic Agents
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Proc Natl Acad Sci U S A. 2014 Oct 28 ;111(43):15550-5. Epub 2014 Oct 13. PMID: 25313065
Article Published Date : Oct 27, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Isothiocyanates, Sulforaphane
Diseases : Autism Spectrum Disorders, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cytoprotective, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Risk Factors
[+]

Supplementation therapy of sulforaphane rich broccoli sprout extract may have the potential to improve cognitive deficits in patients with schizophrenia. Apr 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Psychopharmacol Neurosci. 2015 Apr 30 ;13(1):62-7. PMID: 25912539
Article Published Date : Apr 29, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Schizophrenia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653
Article Published Date : Nov 20, 2015
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Fatty Liver
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

The bioavailability of isothiocyanates from fresh broccoli is approximately three times greater than that from cooked broccoli,Jan 01, 2000

Pubmed Data : Nutr Cancer. 2000;38(2):168-78. PMID: 11525594
Article Published Date : Jan 01, 2000
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Raw versus Cooked
[+]

The bioavailability of sulforaphane from glucoraphanin supplements was equal to that from broccoli sprouts.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0140963. Epub 2015 Nov 2. PMID: 26524341
Article Published Date : Dec 31, 2014
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Additional Keywords : Food Vs. Supplement, Increased Bioavailability, Plant Extracts
[+]

The results of this study found that dosing twice a day may be important for increasing or prolonging certain chemopreventive benefits associated with sulforaphane consumption.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):424-33. Epub 2015 Jan 22. PMID: 25522265
Article Published Date : Feb 28, 2015
Study Type : Human Study
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive
Additional Keywords : Absorption, Bioavailability, Dietary Modification
[+]

These data indicate that cruciferous vegetables may play an important role in decreasing the risk of premenopausal breast cancer.Apr 30, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr. 2004 May ;134(5):1134-8. PMID: 15113959
Article Published Date : Apr 30, 2004
Study Type : Human Study
Additional Links
Substances : Broccoli, Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive, Glutathione S-transferase Inhibitor
[+]

Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.May 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neuropsychiatry. 2018 May ;3(4):214-222. Epub 2018 Apr 17. PMID: 29888232
Article Published Date : May 01, 2018
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Psychiatric Disorders
Pharmacological Actions : Glutathione Upregulation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, psychiatric disorders
[+]

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Mar 30 ;5(6):1621-34. PMID: 24742583
Article Published Date : Mar 29, 2014
Study Type : Human In Vitro
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemotherapeutic
Additional Keywords : Cancer Stem Cells, Dietary Concentrations
[+]

Combination of epigallocatechin gallate and sulforaphane dounteracts In Vitro oxidative stress and delays stemness loss of amniotic fluid stem cells.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5263985. Epub 2018 Dec 17. PMID: 30647811
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Catechin , Sulforaphane
Diseases : Oxidative Stress
Pharmacological Actions : Regenerative
Additional Keywords : Isothiocyanates
[+]

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Pubmed Data : Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID: 29969714
Article Published Date : Jan 20, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidant Effects, Nrf2 activation
Additional Keywords : Antioxidants, Broccoli, Broccoli Sprouts, Cruciferous Vegetables
[+]

Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.Jan 15, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2018 08 15 ;353:23-30. Epub 2018 Jun 6. PMID: 29885333
Article Published Date : Jan 15, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Cadmium Poisoning , Cancers
Pharmacological Actions : Anticarcinogenic Agents, Antioxidant, Antioxidant Effects, Apoptotic, Autophagy Up-regulation, NF-E2-Related Factor-2 (Nrf2) Modulator
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Pubmed Data : Cells Tissues Organs. 2018 ;206(1-2):46-53. Epub 2018 Jul 24. PMID: 30041241
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Anti-Angiogenic, Anti-cancer, Anti-metastatic, Anti-Proliferative, Cyclooxygenase 2 Inhibitors, Hypoxia-inducible factor-1 (HIF-1) inhibitor, Prostaglandin E Synthase-1 (PGES-1) Down-Regulation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables
[+]

Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:4125297. Epub 2018 Nov 18. PMID: 30581529
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Cruciferous Vegetables, Sulforaphane
Diseases : Leukemia
Pharmacological Actions : Antioxidant, Antioxidant Effects, Antiproliferative , NADPH Oxidase Inhibitors
Additional Keywords : Broccoli, Broccoli Sprouts, Isothiocyanates
[+]

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5642148. Epub 2018 Nov 22. PMID: 30595796
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Nrf2 activation
Additional Keywords : calorie restriction, High Sugar Diet, Isothiocyanates
[+]

Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.Sep 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID: 30338040
Article Published Date : Sep 21, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Wnt/β-catenin pathway down-regulation
Additional Keywords : Anti-cancer
[+]

Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.Dec 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID: 30524952
Article Published Date : Dec 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Estrogen
Additional Keywords : Estrogen Positive Breast Cancer, Folate, Methylation
[+]

Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.May 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID: 31137828
Article Published Date : May 27, 2019
Study Type : Human In Vitro
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Insulin Disorders, Insulin Resistance
Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers
Additional Keywords : Broccoli, Cruciferous Vegetables, glucose control, Glucose Uptake Enhancement
[+]

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Pubmed Data : Food Funct. 2015 May 26. Epub 2015 May 26. PMID: 26008201
Article Published Date : May 25, 2015
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Endothelial Damage, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
[+]

Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.Jul 08, 2019

Pubmed Data : Biochim Biophys Acta Mol Basis Dis. 2019 Jul 8 ;1865(10):2586-2594. Epub 2019 Jul 8. PMID: 31295528
Article Published Date : Jul 08, 2019
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Fetal Alcoholism
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Additional Keywords : Alcohol, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Mesenchymal Stem Cells, Pregnancy And Fetal Growth
[+]

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Pubmed Data : Biomed Pharmacother. 2018 Aug ;104:165-171. Epub 2018 May 15. PMID: 29772437
Article Published Date : Aug 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

Pubmed Data : Nutr Cancer. 2016 Nov-Dec;68(8):1338-1348. Epub 2016 Aug 16. PMID: 27636860
Article Published Date : Oct 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Cytoprotective, Nrf2 activation
Additional Keywords : Gene Expression Regulation, Selective Cytotoxicity
[+]

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect.Mar 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2018 Mar 12 ;15(1):75. Epub 2018 Mar 12. PMID: 29530050
Article Published Date : Mar 11, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro. Aug 01, 2019

Pubmed Data : Int J Food Sci Nutr. 2019 Aug ;70(5):570-578. Epub 2019 Jan 9. PMID: 30624124
Article Published Date : Aug 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Gastric Cancer, Gastric Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Anti-cancer
[+]

Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.Jun 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Jun 4 ;10(6). Epub 2018 Jun 4. PMID: 29866995
Article Published Date : Jun 04, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforphane exhibits immunomodulatory properties on human placenta cells in vitro.Feb 01, 2019

Pubmed Data : J Reprod Immunol. 2019 Feb ;131:44-49. Epub 2018 Dec 29. PMID: 30641297
Article Published Date : Feb 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Anti-Inflammatory Agents, Immune Enhancing Properties
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Pregnancy
[+]

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

Pubmed Data : Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID: 15953625
Article Published Date : Dec 01, 2005
Study Type : Human In Vitro
Additional Links
Substances : Broccoli, Sulforaphane, Watercress
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

Pubmed Data : Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID: 30226534
Article Published Date : Nov 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Female, Ovarian Cancer
Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, HER-2 oncoprotein down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Drug Synergy, Isothiocyanates
[+]

"Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin."Oct 31, 2012

Pubmed Data : Mol Nutr Food Res. 2012 Nov ;56(11):1675-87. Epub 2012 Oct 5. PMID: 23038615
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Erucin, Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Chemopreventive
[+]

"Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane."May 28, 2012

Pubmed Data : Mol Carcinog. 2012 May 29. Epub 2012 May 29. PMID: 22641235
Article Published Date : May 28, 2012
Study Type : Insect Study
Additional Links
Substances : Sulforaphane
Diseases : Epstein-Barr Virus Infections, Nasopharyngeal Cancer
[+]

"Neuroprotective effects of sulforaphane after contusive spinal cord injury."Oct 31, 2012

Pubmed Data : J Neurotrauma. 2012 Nov 1 ;29(16):2576-86. Epub 2012 Sep 20. PMID: 22853439
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Neuroprotective Agents
[+]

"Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation."Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2012 ;2012:821936. Epub 2012 Sep 23. PMID: 23050040
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetic Nephropathy
[+]

"Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine."Jun 30, 2012

Pubmed Data : Psychopharmacology (Berl). 2012 Jul ;222(1):37-45. Epub 2011 Dec 27. PMID: 22200890
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Amphetamine Addiction/Withdrawal, Brain: Microglial Activation, Neurodegenerative Diseases
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

Pubmed Data : Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID: 23201461
Article Published Date : Nov 29, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemical Weapon Agent Injury , Skin Cancer: Prevention
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865
Article Published Date : Sep 01, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."Aug 22, 2012

Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492
Article Published Date : Aug 22, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , NSAID-induced toxicity
[+]

A dietary isothiocyanate-enriched moringa seed extract improves glucose tolerance in a high-fat-diet model.Jul 31, 2018

Pubmed Data : J Funct Foods. 2018 Aug ;47:376-385. Epub 2018 Jun 9. PMID: 30930963
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents
[+]

Allyl isothiocyanate ameliorates angiogenesis and inflammation in dextran sulfate sodium-induced acute colitis.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e102975. Epub 2014 Jul 22. PMID: 25051185
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Colitis, Inflammation
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor A Inhibitor
[+]

Allyl isothiocyanate ameliorates dextran sodium sulfate-induced colitis.Jul 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jul 12 ;19(7). Epub 2018 Jul 12. PMID: 30002285
Article Published Date : Jul 11, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Colitis, Inflammatory Bowel Diseases, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Gastrointestinal Agents
[+]

Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease.Sep 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2019 Sep 14 ;25(34):5120-5133. PMID: 31558861
Article Published Date : Sep 13, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hypolipidemic
[+]

Allyl isothiocyanate ameliorates obesity by inhibiting galectin-12.Dec 31, 2017

Pubmed Data : Mol Nutr Food Res. 2018 03 ;62(6):e1700616. Epub 2018 Mar 12. PMID: 29345776
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Hypolipidemic
Additional Keywords : Anti-Obesity Agents
[+]

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury.Jan 31, 2019

Pubmed Data : Mol Biol Rep. 2019 Feb ;46(1):241-250. Epub 2018 Nov 8. PMID: 30406889
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Brain: Oxidative Stress, Inflammation, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Allyl isothiocyanate possesses antidiabetic, antioxidant, and anti-inflammatory activities in high-fat diet/streptozotocin-induced type 2 diabetes mellitus.Jun 30, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Jul ;33(7):e22328. Epub 2019 Mar 30. PMID: 30927557
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation
[+]

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation.Jun 05, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Med Sci. 2018 Jun 6 ;80(6):893-897. Epub 2018 Apr 17. PMID: 29669958
Article Published Date : Jun 05, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.Sep 30, 2003

Pubmed Data : Carcinogenesis. 2003 Oct ;24(10):1665-70. Epub 2003 Aug 1. PMID: 12896904
Article Published Date : Sep 30, 2003
Study Type : Animal Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

Anti-estrogenic and anti-cell proliferative effect of allyl isothiocyanate in chemoprevention of chemically induced mammary carcinogenesis.Mar 19, 2019

Pubmed Data : Pathol Oncol Res. 2019 Mar 20. Epub 2019 Mar 20. PMID: 30895454
Article Published Date : Mar 19, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Estrogenic, Chemopreventive
[+]

Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Sci. 2020 Nov ;21(6):e91. PMID: 33263238
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene.Jul 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Aug ;49(8):1674-83. Epub 2011 Mar 3. PMID: 21376772
Article Published Date : Jul 31, 2011
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Catechin , Ellagic Acid
Diseases : Benzo[a]pyrene-induced Toxicity , DNA damage
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
Problem Substances : Benzo(a)pyrene
[+]

Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID: 29797311
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Stroke
Pharmacological Actions : Platelet aggregation inhibitor: collagen-induced aggregation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables
[+]

Benzyl isothiocyanate ameliorates high-fat diet-induced hyperglycemia.Dec 22, 2020

Pubmed Data : J Agric Food Chem. 2020 Dec 23 ;68(51):15228-15238. Epub 2020 Dec 10. PMID: 33301311
Article Published Date : Dec 22, 2020
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : High Fat Diet, Hyperglycemia
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors
Additional Keywords : Isothiocyanates, Stilbenes
[+]

Benzyl isothiocyanate induces apoptosis and inhibits tumor growth in canine mammary carcinoma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Vet Sci. 2020 ;7:580530. Epub 2020 Nov 11. PMID: 33263014
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Cancers: Canine
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cells.Oct 31, 2018

Pubmed Data : Environ Toxicol. 2018 Nov ;33(11):1097-1104. Epub 2018 Jul 4. PMID: 29972272
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antiproliferative
[+]

Benzyl isothiocyanate inhibits prostate cancer development.Jan 21, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 02 22 ;17(2):264. Epub 2016 Feb 22. PMID: 26907265
Article Published Date : Jan 21, 2016
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest, Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer.Jan 09, 2017

Pubmed Data : Sci Rep. 2017 Jan 10 ;7:40070. Epub 2017 Jan 10. PMID: 28071670
Article Published Date : Jan 09, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

Benzyl isothiocyanate produced by garden cress prevents accumulation of hepatic lipids.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2020 ;66(5):481-487. PMID: 33132353
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Garden Cress (Lepidium sativum)
Diseases : Fatty Liver, Liver Damage
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Benzyl isothiocyanate suppresses development and metastasis of murine mammary carcinoma by regulating the Wnt/β‑catenin pathway.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1808-1818. Epub 2019 Jun 18. PMID: 31257529
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate suppresses high-fat diet-stimulated mammary tumor progression.Dec 31, 2014

Pubmed Data : Mol Carcinog. 2015 Jan ;54(1):72-82. Epub 2014 Apr 11. PMID: 24729546
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer, High Fat Diet
Pharmacological Actions : Antiproliferative
Additional Keywords : Tumor Microenvironment
[+]

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 19144376
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Petroleum Exposure And Toxicity, Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.Oct 10, 2016

Pubmed Data : J Nutr Biochem. 2016 Oct 11 ;39:134-144. Epub 2016 Aug 11. PMID: 27833054
Article Published Date : Oct 10, 2016
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Depression, Depressive Disorder, Inflammation
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Risk Reduction
[+]

Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.Jun 06, 2018

Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925
Article Published Date : Jun 06, 2018
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Malondialdehyde Down-regulation, Nrf2 activation, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Broccoli sprouts can serve as a good dietary source of sulforaphane in vivo and that they have significant inhibitory effects on prostate tumorigenesis.Oct 01, 2009

Pubmed Data : Pharm Res. 2009 Oct;26(10):2324-31. Epub 2009 Aug 8. PMID: 19669099
Article Published Date : Oct 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts
[+]

Broccoli sprouts contain compounds which protect the skin against damage by UV radiation. Oct 30, 2007

Pubmed Data : Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5. Epub 2007 Oct 23. PMID: 17956979
Article Published Date : Oct 30, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Aging Skin
[+]

Brocolli sprout extract and the active compound known as sulforaphane demonstrates chemopreventive action in mammary tissue. Jul 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jul;28(7):1485-90. Epub 2007 Mar 7. PMID: 17347138
Article Published Date : Jul 01, 2007
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
[+]

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Pubmed Data : J Food Sci. 2010 Aug 1;75(6):H190-9. PMID: 20722931
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brussel sprouts, Sulforaphane
Diseases : Chemical Exposure, Intoxication
Pharmacological Actions : Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Cancer-preventive effect of phenethyl isothiocyanate through tumor microenvironment regulation in a colorectal cancer model.Mar 31, 2021

Pubmed Data : Phytomedicine. 2021 Apr ;84:153493. Epub 2021 Feb 4. PMID: 33626429
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells, Tumor Microenvironment
[+]

Co-administration of SFN reversed the DOX-associated reduction in nuclear Nrf2 binding activity and restored cardiac expression of Nrf2-regulated genes, at both the RNA and protein levels.May 25, 2015

Pubmed Data : Free Radic Biol Med. 2015 May 26. Epub 2015 May 26. PMID: 26025579
Article Published Date : May 25, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Nrf2 activation
[+]

Co-treatment with vitamin E, sulphoraphane and Ficus religiosa were found to be effective in reversing cadmium induced reproductive toxicity.Jul 31, 2014

Pubmed Data : Syst Biol Reprod Med. 2014 Aug ;60(4):199-205. Epub 2014 Apr 23. PMID: 24758558
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Fig, Sulforaphane, Vitamin E
Diseases : Cadmium Poisoning , Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
Problem Substances : Cadmium
[+]

Combination of two or three components showed striking synergetic effect with gemcitabine in vitro.Jan 11, 2017

Pubmed Data : Cancer Lett. 2017 Jan 12. Epub 2017 Jan 12. PMID: 28089829
Article Published Date : Jan 11, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Capsaicin, Piceatannol , Resveratrol, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine, Natural Substance Synergy
[+]

Consumption of sulforaphane-enriched broccoli soup may inhibit bacterial growth in the stomach and upper small intestine.Jul 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2020 Jul 10. Epub 2020 Jul 10. PMID: 32651764
Article Published Date : Jul 09, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Escherichia coli Infections
Pharmacological Actions : Antimicrobial
[+]

Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2016 ;7(6):e2246. Epub 2016 Jun 2. PMID: 27253410
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancers: Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Curcumin and phenethyl isothiocyanate have a synergistic inhibitory effect on the growth of human prostate xenografts. Jul 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 16423986
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Curcumin and phenyethylisothiocyanate inhibite mouse prostate cancer. Sep 01, 2008

Pubmed Data : Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 18437538
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID: 26107664
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Cognitive Decline/Dysfunction, Neurologic Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Hematol. 2019 09 ;77:51-60.e1. Epub 2019 Aug 9. PMID: 31404577
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Damage, Sickle Cell Anemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
[+]

Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions.Apr 29, 2007

Pubmed Data : Eur J Pharmacol. 2007 Apr 30 ;561(1-3):172-81. Epub 2007 Jan 27. PMID: 17346695
Article Published Date : Apr 29, 2007
Study Type : Animal Study
Additional Links
Substances : Horseradish, Isothiocyanates
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Gastroprotective
[+]

Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.Feb 15, 2017

Pubmed Data : Diabetes. 2017 Feb 16. Epub 2017 Feb 16. PMID: 28209760
Article Published Date : Feb 15, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Anti-Obesity Agents, Gene Expression Regulation
[+]

Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity.Jul 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Jul 25 ;254:102-8. Epub 2016 May 27. PMID: 27241356
Article Published Date : Jul 24, 2016
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(9):e0184709. Epub 2017 Sep 18. PMID: 28922365
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Isothiocyanates exhibit anti-myeloma activity. Aug 01, 2011

Pubmed Data : Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID: 21712538
Article Published Date : Aug 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Isothiocyanate, Sulforaphane
Diseases : Multiple Myeloma
Pharmacological Actions : Apoptotic
[+]

Moringa isothiocyanate-1 regulates Nrf2 and NF-κB pathway in response to LPS-driven sepsis and inflammation.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2021 ;16(4):e0248691. Epub 2021 Apr 1. PMID: 33793581
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates, Moringa oleifera
Diseases : Inflammation, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation
[+]

Naringin in combination with isothiocyanates as liposomal formulations potentiates the anti-inflammatory activity.Nov 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Omega. 2020 Nov 3 ;5(43):28319-28332. Epub 2020 Oct 26. PMID: 33163815
Article Published Date : Nov 02, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin, Isothiocyanates
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Obesity may increase susceptibility to chronic pain often due to poor diet.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pain. 2018 08 ;22(7):1203-1213. Epub 2018 Mar 2. PMID: 29436058
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Ginseng, Resveratrol, Sulforaphane
Diseases : Chronic Pain, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Inflammatory Diet, Risk Factors
[+]

Oncogenic c-Myc is a target of sulforaphane to prevent and eliminate the onset of human prostate cancer.Mar 14, 2016

Pubmed Data : J Cell Biochem. 2016 Mar 15. Epub 2016 Mar 15. PMID: 26990292
Article Published Date : Mar 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.Sep 15, 2005

Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336
Article Published Date : Sep 15, 2005
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Phenethyl isothiocyanate, Sulforaphane
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity , Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.Aug 01, 2019

Pubmed Data : Cell Oncol (Dordr). 2019 Aug 2. Epub 2019 Aug 2. PMID: 31376137
Article Published Date : Aug 01, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Breast Cancer, Ovarian Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Phenethyl isothiocyanate inhibits in vivo growth of xenograft tumors of human glioblastoma cells.Sep 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 10 ;23(9). Epub 2018 Sep 10. PMID: 30201893
Article Published Date : Sep 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative
[+]

Phenethyl isothiocyanate may act as a promising anticancer agent either alone or in combination with doxorubicin through apoptotic cell death induction.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2018 ;17(4):1328-1338. PMID: 30568691
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Ehrlich carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Phenethyl isothiocyanate protects against high fat/cholesterol diet-induced obesity and atherosclerosis.Nov 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Nov 27 ;12(12). Epub 2020 Nov 27. PMID: 33261070
Article Published Date : Nov 26, 2020
Study Type : Animal Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Phenethyl isothiocyanate treatment suppressed the proliferation of ALDH1 expressing cancer stem cells.Feb 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 27 ;20(5). Epub 2019 Feb 27. PMID: 30818757
Article Published Date : Feb 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Pre-treatment with sulforaphane or thymoquinone can reduce acetylsalicylic acid-induced gastric ulcers.Jun 14, 2016

Pubmed Data : J Surg Res. 2016 Jun 15 ;203(2):348-59. Epub 2016 Mar 24. PMID: 27363643
Article Published Date : Jun 14, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane, Thymoquinone
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Gastroprotective
[+]

Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.Apr 12, 2018

Pubmed Data : Carcinogenesis. 2018 Apr 13. Epub 2018 Apr 13. PMID: 29668854
Article Published Date : Apr 12, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
[+]

Protective effects of sulforaphane and aerobic exercise on acute alcoholic hepatic injury in mice.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Nov ;27(11):3145-3149. Epub 2020 Jul 14. PMID: 33100876
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alcoholic Liver Disease
Therapeutic Actions : Exercise: Aerobic
Pharmacological Actions : Hepatoprotective
[+]

Protective effects of sulforaphane in experimental vascular cognitive impairment.Dec 31, 2017

Pubmed Data : J Cereb Blood Flow Metab. 2018 Jan 1:271678X18764083. Epub 2018 Jan 1. PMID: 29533123
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents, Nrf2 activation
[+]

Protective effects of sulforaphane on exercise-induced organ damage via inducing antioxidant defense responses.Feb 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Feb 4 ;9(2). Epub 2020 Feb 4. PMID: 32033211
Article Published Date : Feb 03, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Muscle Damage: Exercise-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabolism. 2020 Jan ;102:154002. Epub 2019 Nov 9. PMID: 31706979
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiomyopathy, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.Jan 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Differ. 2016 10 ;23(10):1615-27. Epub 2016 Jun 3. PMID: 27258787
Article Published Date : Jan 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

Sufloraphane has a protective effect on preserved pancreas and may have a potential clinical implication to improve hemodynamically unstable pancreas donor condition.Jan 01, 2004

Pubmed Data : Ann Transplant. 2004;9(3):68-71. PMID: 15759553
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions : Antioxidants
[+]

Suforaphane, a compound found within broccoli, inhibits lung metastasis induced by melanoma cells in tumor-bearing animals. Oct 01, 2006

Pubmed Data : Breast Cancer Res Treat. 2006 Oct;99(3):333-40. Epub 2006 May 9. PMID: 16600309
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Lung Cancer, Melanoma, Melanoma: Metastatic
Pharmacological Actions : Anti-metastatic
[+]

Sulforaphane alone or in combination with other therapies may be potentially useful for glioblastoma therapy.Jan 05, 2017

Pubmed Data : J Neurosurg. 2017 Jan 6:1-12. Epub 2017 Jan 6. PMID: 28059653
Article Published Date : Jan 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Antiproliferative, Apoptotic, Cancer Stem Cells, glioblastoma (GBM), Sulforaphane
[+]

Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS.Jul 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : AMB Express. 2020 Jul 3 ;10(1):119. Epub 2020 Jul 3. PMID: 32621086
Article Published Date : Jul 02, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.Feb 18, 2019

Pubmed Data : Behav Brain Res. 2019 Feb 19 ;364:213-224. Epub 2019 Feb 19. PMID: 30790585
Article Published Date : Feb 18, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Autism
Pharmacological Actions : Antioxidants, Immunomodulatory: Th17 downregulation, Nrf2 activation
[+]

Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice.Jun 30, 2019

Pubmed Data : Biol Reprod. 2019 Jul 1 ;101(1):223-234. PMID: 31004475
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : High Fat Diet, Infertility: Male
Pharmacological Actions : Fertility Agents: Male
[+]

Sulforaphane ameliorates okadaic acid induced memory impairment in rats by activating the Nrf2/HO-1 antioxidant pathway.Oct 02, 2015

Pubmed Data : Mol Neurobiol. 2015 Oct 3. Epub 2015 Oct 3. PMID: 26433376
Article Published Date : Oct 02, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Inflammation , Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane ameliorates some features of clinical diabetic complications particularly the lipid profile and insulin responsiveness.Apr 19, 2016

Pubmed Data : Food Funct. 2016 Apr 20 ;7(4):2060-5. PMID: 27025193
Article Published Date : Apr 19, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetic Complications, Insulin Resistance
Pharmacological Actions : Hypolipidemic
[+]

Sulforaphane and curcumin protect against malathion toxicity. Jun 30, 2012

Pubmed Data : Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID: 22957429
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Curcumin, Sulforaphane
Diseases : Malathion Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sulforaphane and dibenzoylmethane alone as well as their combination are potent natural dietary compounds for chemoprevention of gastrointestinal cancers.Oct 15, 2007

Pubmed Data : Cancer Res. 2007 Oct 15;67(20):9937-44. PMID: 17942926
Article Published Date : Oct 15, 2007
Study Type : Animal Study
Additional Links
Substances : Dibenzoylmethane (DBM), Sulforaphane
Diseases : Adenomatous Polyposis Coli, Gastrointestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive
[+]

Sulforaphane and NAC (N-acetyl-L-cysteine) upregulate T(H)1 immunity in aging.May 01, 2008

Pubmed Data : J Allergy Clin Immunol. 2008 May;121(5):1255-1261.e7. Epub 2008 Mar 5. PMID: 18325578
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Sulforaphane
Diseases : Aging, Immune Disorders: Low Immune Function, Immune Dysregulation: TH1/TH2 imbalance, Low Disorders: Low TH1
Pharmacological Actions : Antioxidants, Immunomodulatory
[+]

Sulforaphane and vitamin E could ameliorate cognitive decline and oxidative damage in pups with lead exposure at lactation from maternal milk.Nov 30, 2017

Pubmed Data : J Trace Elem Med Biol. 2017 Dec ;44:88-92. Epub 2017 Jun 15. PMID: 28965607
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane, Vitamin E
Diseases : Cognitive Decline/Dysfunction, Lead Poisoning
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Lead
[+]

Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose.Mar 17, 2020

Pubmed Data : Neurochem Int. 2020 Mar 18:104728. Epub 2020 Mar 18. PMID: 32199985
Article Published Date : Mar 17, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice.Oct 03, 2017

Pubmed Data : J Nutr Biochem. 2017 Oct 4 ;51:69-79. Epub 2017 Oct 4. PMID: 29096318
Article Published Date : Oct 03, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane contributes to the protection of gastrointestinal mucosa against oxidative injury induced by H. pylori or NSAIDs.Feb 05, 2017

Pubmed Data : Curr Pharm Des. 2017 Feb 6. Epub 2017 Feb 6. PMID: 28176666
Article Published Date : Feb 05, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aspirin-Induced Toxicity , Drug-Induced Toxicity: Indomethacin, Helicobacter Pylori Infection, NSAID-induced toxicity
Pharmacological Actions : Antioxidants
Problem Substances : Aspirin , Indomethacin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sulforaphane could inhibit inflammation in human umbilical vein ECs exposed to advanced glycation end products.Apr 20, 2016

Pubmed Data : Nutr Metab Cardiovasc Dis. 2016 Apr 21. Epub 2016 Apr 21. PMID: 27212619
Article Published Date : Apr 20, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Sulforaphane could prevent the memory impairment and apoptosis of hippocampal neurons in diabetic rat.Aug 08, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 Aug 9 ;39(3):901-907. Epub 2016 Aug 9. PMID: 27497670
Article Published Date : Aug 08, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes: Memory Problems, Diabetic Complications
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.Aug 01, 2018

Pubmed Data : Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151
Article Published Date : Aug 01, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Malonaldehyde (MDA) Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Neuroprotective Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.Feb 01, 2019

Pubmed Data : Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379
Article Published Date : Feb 01, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Dyslipidemias, Fatty Liver, Insulin Resistance
Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents, Insulin Sensitizers
Additional Keywords : Isothiocyanates
Problem Substances : Fructose
[+]

Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.Nov 15, 2005

Pubmed Data : J Neurosci Res. 2005 Nov 15;82(4):499-506. PMID: 16211562
Article Published Date : Nov 15, 2005
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Edema, Traumatic Brain Injury
[+]

Sulforaphane enhances leptin sensitivity and prevents weigh gain in diet-induced obese mice.Sep 15, 2018

Pubmed Data : Eur J Pharmacol. 2018 Sep 15 ;835:108-114. Epub 2018 Jul 29. PMID: 30063917
Article Published Date : Sep 15, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Obesity
Additional Keywords : Body Mass Index (BMI), Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates, leptin
[+]

Sulforaphane enhances lipid metabolism through improved mitochondrial function by Nrf-2 and PGC-1a-dependent mechanisms.Jan 01, 2019

Pubmed Data : Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID: 30578708
Article Published Date : Jan 01, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Mitochondrial Dysfunction
Pharmacological Actions : Lipolytic, Nrf2 activation, Peroxisome Proliferators
Additional Keywords : Mitochondria, mitochondria dysfunction, Mitochondrial Biogenesis
[+]

Sulforaphane enhances the anticancer activity of a chemo-agent against pancreatic cancer. Aug 29, 2011

Pubmed Data : Nutr Cancer. 2011 Aug 29. Epub 2011 Aug 29. PMID: 21875325
Article Published Date : Aug 29, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug Synergy
[+]

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.Nov 01, 2008

Pubmed Data : Clin Cancer Res. 2008 Nov 1;14(21):6855-66. PMID: 18980980
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma.Oct 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Oct 4 ;7(1):12651. Epub 2017 Oct 4. PMID: 28978924
Article Published Date : Oct 03, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Chemopreventive, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Sulforaphane exhibits antiproliferative, apoptotic, anti-inflammatory, and anti-angiogenic properties and ameliorates a rat model of endometriosis.Apr 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID: 31217757
Article Published Date : Apr 01, 2019
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Endometriosis
Pharmacological Actions : Anti-Angiogenic, Anti Inflammatory, Antiproliferative , Apoptotic, Interferon Gamma Reducer, Interleukin-10 downregulation, PI3K-AKT inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Cytokines, Inflammation, Interleukin-6 Downregulation, women's health
[+]

Sulforaphane exhibits chemopreventive properties against intestinal polyps in mice.Dec 01, 2006

Pubmed Data : Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 16952200
Article Published Date : Dec 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors
[+]

Sulforaphane has anticonvulsant properties and could improve mitochondrial function.Sep 13, 2015

Pubmed Data : J Neurochem. 2015 Sep 14. Epub 2015 Sep 14. PMID: 26365487
Article Published Date : Sep 13, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Nrf2 activation
[+]

Sulforaphane has antidepressant and anxiolytic like activities in stressed mice model of depression.Dec 21, 2015

Pubmed Data : Behav Brain Res. 2015 Dec 22 ;301:55-62. Epub 2015 Dec 22. PMID: 26721468
Article Published Date : Dec 21, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane has both anti-nociceptive and anti-inflammatory actions.Jan 31, 2017

Pubmed Data : Inflammopharmacology. 2017 Feb ;25(1):99-106. Epub 2017 Jan 4. PMID: 28054242
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Sulforaphane has immunomodulatory properties.Aug 01, 2007

Pubmed Data : Phytomedicine. 2007 Aug;14(7-8):538-45. Epub 2006 Nov 3. PMID: 17084602
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Immune Disorders: Low Immune Function
Pharmacological Actions : Immunomodulatory
[+]

Sulforaphane has potential as a therapeutic agent to protect T2DM patients from cognitive deficiencies.Apr 19, 2018

Pubmed Data : Neuroscience. 2018 Apr 20. Epub 2018 Apr 20. PMID: 29684505
Article Published Date : Apr 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes: Cognitive Dysfunction
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane has preventive action in oxidative stress-mediated liver injury associated with acetaminophen (APAP)-induced toxicity.May 31, 2015

Pubmed Data : Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID: 25818464
Article Published Date : May 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Sulforaphane has significant protective effects against oxidative stress and could ameliorate bladder dysfunction.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:7598294. Epub 2016 Jun 28. PMID: 27433291
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Dysfunction , Bladder Outlet Obstruction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane has the potential to prevent neuronal disorders by enhancing Brain-derived Neurotrophic Factor (BDNF) and its TrkB signaling pathways. Jan 01, 2017

Pubmed Data : Mol Nutr Food Res. 2017 02 ;61(2). Epub 2016 Nov 30. PMID: 27735126
Article Published Date : Jan 01, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Brain-derived neurotrophic factor modulator
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Epigenetic Modification, Isothiocyanates
[+]

Sulforaphane improved cardiac function and remodelling by inhibiting oxidative stress and inflammation.Mar 11, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Mar 12 ;24:1473-1483. Epub 2018 Mar 12. PMID: 29527002
Article Published Date : Mar 11, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Heart Failure
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Sulforaphane improved islet function in vivo, indicating that combination of a free radical scavenger and an antioxidant (sulforaphane) may be used to increase the effectiveness of islet transplantation.Feb 01, 2010

Pubmed Data : Muscle Nerve. 2010 Feb;41(2):185-90. PMID: 16504726
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Organ Transplantation, Organ Transplantation: Pancreatic Islet Cells
Pharmacological Actions : Anticarcinogenic Agents
[+]

Sulforaphane improves cognitive function administered following traumatic brain injury.Aug 28, 2009

Pubmed Data : Neurosci Lett. 2009 Aug 28;460(2):103-7. Epub 2009 Apr 15. PMID: 19515491
Article Published Date : Aug 28, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Blood-Brain-Barrier Disorders, Brain Damage, Brain Injury: Traumatic, Cognitive Decline/Dysfunction
Pharmacological Actions : Anticarcinogenic Agents, Neuroprotective Agents
[+]

Sulforaphane improves LPS-induced spatial learning and memory dysfunction, likely by upregulating neurogenesis through the BDNF-mTOR pathway.Jan 15, 2018

Pubmed Data : Neuroscience. 2018 09 15 ;388:357-366. Epub 2018 Aug 4. PMID: 30086367
Article Published Date : Jan 15, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Neurogenesis
Additional Keywords : Brain-derived neurotrophic factor modulator, Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane improves neuronal mitochondrial function in brain tissue in acute carbon monoxide poisoning.Dec 15, 2016

Pubmed Data : Basic Clin Pharmacol Toxicol. 2016 Dec 16. Epub 2016 Dec 16. PMID: 27983767
Article Published Date : Dec 15, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Carbon Monoxide Poisoning
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injuryFeb 08, 2017

Pubmed Data : Int Immunopharmacol. 2017 Feb 9 ;45:74-78. Epub 2017 Feb 9. PMID: 28189971
Article Published Date : Feb 08, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation
[+]

Sulforaphane increases cell-mediated immune response in melanoma-induced metastatic tumor-bearing mice.Apr 01, 2010

Pubmed Data : J Clin Invest. 2010 Apr 1;120(4):1043-55. Epub 2010 Mar 24. PMID: 17849266
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Interleukin-1 beta downregulation, Interleukin-2 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane increases the effectiveness of various cytotoxic drugs against pancreatic cancer stem cells without inducing additional toxicity in mice.Jun 01, 2004

Pubmed Data : J Med Food. 2004 Summer;7(2):157-61. PMID: 20940707
Article Published Date : Jun 01, 2004
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancers: Multi-Drug Resistant, Pancreatic Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Sulforaphane induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting NF-κB signaling pathway.May 25, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2015 May 26. Epub 2015 May 26. PMID: 26013831
Article Published Date : May 25, 2015
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Duchenne's Muscular Dystrophy, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.Nov 01, 2007

Pubmed Data : Oncol Rep. 2007 Nov;18(5):1263-8. PMID: 17914583
Article Published Date : Nov 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Osteosarcoma
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane induces cell cycle arrest and programmed cell death in human lung cancer cells and retards growth of human lung cancer tumors in a xenograft animal model.Oct 15, 2008

Pubmed Data : J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID: 18855447
Article Published Date : Oct 15, 2008
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Sulforaphane induces cell death in primary human colorectal cancer. Jan 01, 2012

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:415231. Epub 2011 Jul 17. PMID: 21804859
Article Published Date : Jan 01, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic
[+]

Sulforaphane induces miR135b-5p and its target gene to inhibit the progression of pancreatic cancer.Sep 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Ther Oncolytics. 2019 Sep 27 ;14:74-81. Epub 2019 Apr 6. PMID: 31044154
Article Published Date : Sep 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , MicroRNA modulator
[+]

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.May 28, 2002

Pubmed Data : Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5. PMID: 12032331
Article Published Date : May 28, 2002
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Gastric Cancer, Helicobacter Pylori Infection
Additional Keywords : Multi-Drug Resistant Pathogens
[+]

Sulforaphane inhibits multiple inflammasomes through a novel mechanism and contributes to our understanding of the beneficial effects of sulforaphane.Aug 11, 2015

Pubmed Data : J Leukoc Biol. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26269198
Article Published Date : Aug 11, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gout, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Sulforaphane inhibits oral cancer cell growth in vitro and in an animal model.Jan 01, 2010

Pubmed Data : J Clin Biochem Nutr. 2010 Jan;46(1):60-7. Epub 2009 Dec 29. PMID: 20104266
Article Published Date : Jan 01, 2010
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oral Cancer
Pharmacological Actions : Cell cycle arrest
[+]

Sulforaphane inhibits pancreatic cancer proliferation through AMPK activation and Nrf2 translocation in vitro and in vivo.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;50(3):1201-1215. Epub 2018 Oct 24. PMID: 30355942
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Tumor, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Nrf2 activation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in association with increased cytotoxicity of natural killer cells.Mar 01, 2009

Pubmed Data : Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17. PMID: 19223537
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cancer Metastasis, Low Immune Function: Natural Killer Cells, Lung Cancer, Prostate Cancer
Pharmacological Actions : Anti-Angiogenic, Anticarcinogenic Agents, Antiproliferative , Apoptotic
[+]

Sulforaphane inhibits respiratory syncytial virus replication and virus-induced inflammation in the lungs of mice.Jan 15, 2009

Pubmed Data : Am J Respir Crit Care Med. 2009 Jan 15;179(2):138-50. Epub 2008 Oct 17. PMID: 18931336
Article Published Date : Jan 15, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Respiratory Syncytial Virus Infections, Respiratory Tract Infections
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiviral Agents
[+]

Sulforaphane inhibits the acquisition of tobacco smoke-induced lung cancer stem cell-like properties.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Theranostics. 2019 ;9(16):4827-4840. Epub 2019 Jul 9. PMID: 31367260
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity
Pharmacological Actions : Chemopreventive
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane inhibits vestibular schwannoma growth in vitro and in vivo.Nov 01, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 2 ;6:36215. Epub 2016 Aug 2. PMID: 27805058
Article Published Date : Nov 01, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Schwannoma: Vestibular
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID: 26036303
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Sulforaphane is a promising agent to restore glucose tolerance through upregulation of insulin signaling in obese mice.Sep 19, 2018

Pubmed Data : Food Funct. 2018 Sep 19 ;9(9):4695-4701. PMID: 30091431
Article Published Date : Sep 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Insulin Resistance
Pharmacological Actions : Glucose Uptake Optimization, Insulin Sensitizers
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
Problem Substances : Insulin
[+]

Sulforaphane is a protective agent against acetaminophen-induced liver damage.Dec 31, 2016

Pubmed Data : Bratisl Lek Listy. 2017 ;118(8):453-459. PMID: 29050482
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Sulforaphane may attenuate aflatoxin-induced liver carcinogenesis. May 01, 2011

Pubmed Data : Toxicol Sci. 2011 May ;121(1):57-62. Epub 2011 Jan 28. PMID: 21278056
Article Published Date : May 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aflatoxicosis, Liver Cancer, Liver Damage: Aflatoxin-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Problem Substances : Aflatoxin
[+]

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID: 26531002
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-E2-Related Factor-2 (Nrf2) Modulator, Prostaglandin PGE2 downregulation
[+]

Sulforaphane may be a potential compound that can inhibit Aβ oligomer production in Alzheimer's disease.Dec 31, 2017

Pubmed Data : J Alzheimers Dis. 2018 ;62(4):1803-1813. PMID: 29614663
Article Published Date : Dec 31, 2017
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane may have therapeutic value in the treatment of rheumatoid arthritis.Jan 01, 2010

Pubmed Data : Arthritis Rheum. 2010 Jan;62(1):159-70. PMID: 20039434
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane may modulate serotonin levels.Jul 01, 2008

Pubmed Data : Cancer Res. 2008 Jul 1;68(13):5487-91. PMID: 18593952
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Serotonin Disorders
Pharmacological Actions : Serotonergic
[+]

Sulforaphane might be a promising therapeutic agent for cognitive enhancement in Alzheimer's disease.Jun 01, 2016

Pubmed Data : Neurochem Res. 2016 Jun 2. Epub 2016 Jun 2. PMID: 27255600
Article Published Date : Jun 01, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane might emerge as a novel strategy to protect the bladder against ischemia-induced oxidative damage.Nov 07, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Nov 8 ;6:36110. Epub 2016 Aug 8. PMID: 27824068
Article Published Date : Nov 07, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors
[+]

Sulforaphane normalizes intestinal flora and enhances gut barrier in mice with BBN-induced bladder cancer.Jan 11, 2018

Pubmed Data : Mol Nutr Food Res. 2018 12 ;62(24):e1800427. Epub 2018 Nov 22. PMID: 30302904
Article Published Date : Jan 11, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Gastrointestinal Agents, Interleukin-6 Downregulation
[+]

Sulforaphane normalizes the kidney epigenome and improves blood pressure in hypertensive rats.Nov 03, 2011

Pubmed Data : Am J Hypertens. 2011 Nov 3. Epub 2011 Nov 3. PMID: 22052072
Article Published Date : Nov 03, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Hypertension, Kidney Diseases
Pharmacological Actions : Hypotensive
Additional Keywords : Epigenetic Modification
[+]

Sulforaphane offers protection against angiotensin II induced testicular injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:5374897. Epub 2017 Jan 16. PMID: 28191275
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
[+]

Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent.Jan 01, 2006

Pubmed Data : BMC Cancer. 2006;6:62. Epub 2006 Mar 15. PMID: 16539699
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling.Oct 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Cell. 2020 Oct 17:e13261. Epub 2020 Oct 17. PMID: 33067900
Article Published Date : Oct 16, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Aging: Heart, Cardiovascular Diseases
Pharmacological Actions : Antioxidants, Cardioprotective, Nrf2 activation
[+]

Sulforaphane prevents and/or retards adenoma formation in the gastrointestinal tract of mice.Oct 01, 2006

Pubmed Data : Carcinogenesis. 2006 Oct;27(10):2038-46. Epub 2006 May 4. PMID: 16675473
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Adenomatous Polyposis Coli, Colorectal Cancer, Intestinal Polyps
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
[+]

Sulforaphane prevents cell death and inflammation in nephropathy.Jun 16, 2011

Pubmed Data : J Nutr Biochem. 2011 Jun 16. Epub 2011 Jun 16. PMID: 21684138
Article Published Date : Jun 16, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Nephropathy
Pharmacological Actions : Renoprotective
Problem Substances : Cisplatin
Adverse Pharmacological Actions : Nephrotoxic
[+]

Sulforaphane prevents chemically-induced skin cancer in mice.Aug 15, 2006

Pubmed Data : Cancer Res. 2006 Aug 15;66(16):8293-6. PMID: 16912211
Article Published Date : Aug 15, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Cancer, Skin Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity.Jan 06, 2016

Pubmed Data : Mol Neurobiol. 2016 Jan 7. Epub 2016 Jan 7. PMID: 26742517
Article Published Date : Jan 06, 2016
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Mercury Poisoning, Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective, Nrf2 activation
[+]

Sulforaphane prevents retinal ganglion cell death and acts as a potent neuroprotective modulator in retinal ischemia/reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. PMID: 31266422
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension.Mar 31, 2020

Pubmed Data : Am J Physiol Heart Circ Physiol. 2020 Apr 1 ;318(4):H853-H866. Epub 2020 Feb 28. PMID: 32108526
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Pulmonary Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation
[+]

Sulforaphane protects against benzo(a)pyrene induced toxicity. Sep 15, 2010

Pubmed Data : Pulm Pharmacol Ther. 2010 Sep 15. Epub 2010 Sep 15. PMID: 20833254
Article Published Date : Sep 15, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Benzo[a]pyrene-induced Toxicity
Pharmacological Actions : Antioxidants
[+]

Sulforaphane protects against cadmium-induced testicular injury by activation of Nrf2-ARE pathway.Jul 19, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Jul 19 ;23(7). Epub 2018 Jul 19. PMID: 30029485
Article Published Date : Jul 19, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Heavy Metal Toxicity, Oxidative Stress, Testicular Injury: Cadmium-Induced
Pharmacological Actions : Antioxidants, Apoptotic
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane protects against cisplatin-induced liver and mitochondrial damage. Aug 15, 2011

Pubmed Data : Toxicology. 2011 Aug 15 ;286(1-3):20-7. Epub 2011 May 6. PMID: 21575670
Article Published Date : Aug 15, 2011
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antioxidants
Problem Substances : Cisplatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Sulforaphane protects against cisplatin-induced nephrotoxicity.Aug 01, 2007

Pubmed Data : Int J Sport Nutr Exerc Metab. 2007 Aug;17(4):352-63. PMID: 19913604
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity, Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Apoptotic, Renoprotective
[+]

Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.Feb 15, 2009

Pubmed Data : Toxicol Appl Pharmacol. 2009 Feb 15;235(1):57-67. Epub 2008 Nov 21. PMID: 19071154
Article Published Date : Feb 15, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 1: Prevention
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Beta Cell Protection, Beta Cell Regeneration
[+]

Sulforaphane protects against hypoxic-ischemic injury.Jul 09, 2010

Pubmed Data : Brain Res. 2010 Jul 9;1343:178-85. Epub 2010 Apr 24. PMID: 20417626
Article Published Date : Jul 09, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia, Hypoxia, Stroke
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane protects against intermittent hypoxia-induced cardiomyopathy through Nrf2 activation.Jan 10, 2018

Pubmed Data : Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID: 30096613
Article Published Date : Jan 10, 2018
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiomyopathy, Hypoxia
Pharmacological Actions : Antioxidant Effects, Metallothionein Up-regulation, Nrf2 activation
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
[+]

Sulforaphane protects against skeletal muscle dysfunction in spontaneous type 2 diabetic Db/Db mice. May 19, 2020

Pubmed Data : Life Sci. 2020 May 20 ;255:117823. Epub 2020 May 20. PMID: 32445760
Article Published Date : May 19, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Musculoskeletal Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Sulforaphane protects ischemic injury of hearts.Aug 11, 2008

Pubmed Data : Phytother Res. 2008 Aug 11. PMID: 19948220
Article Published Date : Aug 11, 2008
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Myocardial Infarction, Myocardial Ischemia
Pharmacological Actions : Antioxidants
[+]

Sulforaphane protects liver injury induced by intestinal ischemia in an animal model. Jun 28, 2010

Pubmed Data : World J Gastroenterol. 2010 Jun 28;16(24):3002-10. PMID: 20572303
Article Published Date : Jun 28, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Intestinal Diseases, Liver Disease
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants
[+]

Sulforaphane protects piglet brains from neonatal hypoxic-ischemic injury.Dec 09, 2020

Pubmed Data : Dev Neurosci. 2020 Dec 10:1-11. Epub 2020 Dec 10. PMID: 33302269
Article Published Date : Dec 09, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Ischemia
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane protects the male reproductive system of mice from obesity-induced damage.Oct 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2019 Oct 7 ;16(19). Epub 2019 Oct 7. PMID: 31591291
Article Published Date : Oct 06, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Hypogonadism, Obesity
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Nrf2 activation
[+]

Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents.Jan 30, 2006

Pubmed Data : Neurosci Lett. 2006 Jan 30;393(2-3):108-12. Epub 2005 Oct 17. PMID: 16233958
Article Published Date : Jan 30, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia, Stroke: Recovery
Pharmacological Actions : Neuroprotective Agents
[+]

Sulforaphane reduces inflammation following spinal cord injury in mice.Jan 01, 2010

Pubmed Data : Ann Clin Lab Sci. 2010;40(4):354-60. PMID: 20947810
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sulforaphane reduces the apoptosis of neurons in brain trauma-induced diffuse axonal injury.Jun 23, 2019

Pubmed Data : J Cell Biochem. 2019 Jun 24. Epub 2019 Jun 24. PMID: 31232487
Article Published Date : Jun 23, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Damage
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation
[+]

Sulforaphane significantly decreased leptin-induced vascular smooth muscle cell proliferation.Mar 09, 2016

Pubmed Data : J Nutr Biochem. 2016 Mar 10 ;32:73-84. Epub 2016 Mar 10. PMID: 27142739
Article Published Date : Mar 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Atherosclerosis, Obesity
Pharmacological Actions : Leptin Down-Regulation
Anti Therapeutic Actions : Western Diet
[+]

Sulforaphane supplementation normalize endothelial dysfunction associated with type 2 diabetes.Oct 29, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Oct 30 ;7(1):14357. Epub 2017 Oct 30. PMID: 29085055
Article Published Date : Oct 29, 2017
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Nrf2 activation
[+]

Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.Jan 01, 2019

Pubmed Data : Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID: 30315662
Article Published Date : Jan 01, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Skin Cancer: Prevention
Pharmacological Actions : Anti Inflammatory, Anticarcinogenic Agents, Antioxidant, Antioxidant Effects, Antiproliferative , Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Ultraviolet Radiation Induced Damage
[+]

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia, indicating it may have a therapeutic role in reducing brain inflammation.Jun 01, 2010

Pubmed Data : Inflamm Res. 2010 Jun;59(6):443-50. Epub 2009 Nov 19. PMID: 19924513
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain: Microglial Activation, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, NF-kappaB Inhibitor
[+]

Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells In vitro and in vivo.Jan 23, 2019

Pubmed Data : Cancer Prev Res (Phila). 2019 Jan 24. Epub 2019 Jan 24. PMID: 30679159
Article Published Date : Jan 23, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Chemotherapeutic
Additional Keywords : Cancer Stem Cells
[+]

Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats.Oct 01, 2009

Pubmed Data : J Appl Physiol. 2009 Oct;107(4):1028-36. Epub 2009 Aug 27. PMID: 19713431
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Muscle Damage: Exercise-Induced, Muscle Fatigue, Muscle Soreness, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma.Jul 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 15 ;855:276-284. Epub 2019 May 14. PMID: 31100413
Article Published Date : Jul 14, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Asthma
Pharmacological Actions : Antioxidants, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation
[+]

Sulforaphane treatment upregulates CHIP and has the potential to decrease the accumulation of Aβ and tau in patients with Alzheimer's disease.Apr 29, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Apr 30:e1800240. Epub 2018 Apr 30. PMID: 29714053
Article Published Date : Apr 29, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Heat Shock Protein Inducer, Neuroprotective Agents
[+]

Sulforaphane's anti-inflammatory, antioxidant, and neuroprotective benefits attentuate autoimmune encephalomyelitis in an animal model of Multiple Sclerosis.Jul 22, 2019

Pubmed Data : J Korean Med Sci. 2019 Jul 22 ;34(28):e197. Epub 2019 Jul 22. PMID: 31327180
Article Published Date : Jul 22, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Autoimmune Diseases, Multiple Sclerosis
Therapeutic Actions : anti-inflammatory, antioxidant, neuro-protective
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidant Effects, Neuroprotective Agents, Nitric Oxide Inhibitor
Additional Keywords : Antioxidant, Autoimmune Diseases, Cruciferous Vegetables, Multiple Sclerosis, Phytotherapy, Sulforaphane
[+]

Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts has profound anti-Helicobacter pylori activity in human gastric xenografts implanted in nude mice. Dec 01, 2003

Pubmed Data : Antimicrob Agents Chemother. 2003 Dec;47(12):3982-4. PMID: 14638516
Article Published Date : Dec 01, 2003
Study Type : Transgenic Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Helicobacter Pylori Infection
Additional Keywords : Plant Extracts
[+]

Sulforaphane-containing broccoli sprout extracts protect against UV-light-induced skin carcinogenesis.Aug 28, 2006

Pubmed Data : Cancer Lett. 2006 Aug 28;240(2):243-52. Epub 2005 Nov 3. PMID: 16271437
Article Published Date : Aug 28, 2006
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : DNA damage, Light Sensitivity, Oxidative Stress, Skin Diseases: Photo-Aging
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Radioprotective
Additional Keywords : Plant Extracts
[+]

Sulforaphene induces apoptosis and inhibits the invasion of esophageal cancer.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2019 ;19:342. Epub 2019 Dec 19. PMID: 31889894
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic
[+]

Sulforphane attenuates oxidative stress and neuronal damage following traumatic brain injury. Oct 18, 2010

Pubmed Data : Acta Pharmacol Sin. 2010 Oct 18. Epub 2010 Oct 18. PMID: 20953205
Article Published Date : Oct 18, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Brain Injury: Traumatic, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2015 ;5(8):2516-30. Epub 2015 Jul 15. PMID: 26396928
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Lung Cancer, Ovarian Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Temporal efficacy of a sulforaphane-based broccoli sprout diet in prevention of breast cancer through modulation of epigenetic mechanisms.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2018 Aug ;11(8):451-464. Epub 2018 May 15. PMID: 29764806
Article Published Date : Jul 31, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Broccoli Sprouts, Cruciferous Vegetables, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Epigenetic Modification In Cancer
[+]

The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: role in epigenetic regulation.Jun 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jun 13 ;19(6). Epub 2018 Jun 13. PMID: 29899271
Article Published Date : Jun 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genistein, Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Natural Substance Synergy
[+]

The present study indicates that benzyl isothiocyanate has the ability to inhibit breast cancer-induced osteolytic bone resorption in vivo.Feb 08, 2018

Pubmed Data : Carcinogenesis. 2018 Feb 9 ;39(2):134-145. PMID: 29040431
Article Published Date : Feb 08, 2018
Study Type : Transgenic Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Cachexia: Cancer
Pharmacological Actions : Anti-Cachexic Agents, Chemotherapeutic
[+]

The present study suggested that sulforaphane exerted a therapeutic effect in the atopic dermatitis.Jul 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Aug ;20(2):1761-1771. Epub 2019 Jun 20. PMID: 31257541
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Atopic Dermatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

The result suggests that allyl isothiocyanate has anti-inflammatory potential to prevent DMBA- and MNU-induced mammary carcinogenesis.Dec 31, 2017

Pubmed Data : Breast Cancer. 2018 Jan ;25(1):50-59. Epub 2017 May 13. PMID: 28501931
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These findings indicate that benzyl isothiocyanate and phenethyl isothiocyanate ameliorate high fat diet-induced obesity and fatty liver.Jun 25, 2019

Pubmed Data : J Agric Food Chem. 2019 Jun 26 ;67(25):7136-7146. Epub 2019 Jun 18. PMID: 31240929
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Fatty Liver, Obesity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Anti-Obesity Agents
[+]

This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochemistry (Mosc). 2020 Jul ;85(7):833-837. PMID: 33040727
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Resveratrol, Sulforaphane
Diseases : Coronavirus Infection, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation
Additional Keywords : Cytokine Storm
[+]

Young radish and sulforaphane protect against carbon tetrachloride-induced liver damage.May 01, 2008

Pubmed Data : Biosci Biotechnol Biochem. 2008 May;72(5):1176-82. Epub 2008 May 7. PMID: 18460814
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Radish, Sulforaphane
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

β-phenylethyl isothiocyanate could be a functional ingredient for oral cancer prevention.Jul 16, 2018

Pubmed Data : Food Funct. 2018 Jul 17 ;9(7):3640-3656. PMID: 29923573
Article Published Date : Jul 16, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation
[+]

Sulforaphane suppresses obesity-related glomerulopathy-induced damage by enhancing autophagy via Nrf2.Jul 28, 2020

Pubmed Data : Life Sci. 2020 Jul 29 ;258:118153. Epub 2020 Jul 29. PMID: 32738361
Article Published Date : Jul 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Obesity
Pharmacological Actions : Autophagy Up-regulation
Additional Keywords : Anti-Obesity Agents
[+]

"Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway."Jun 30, 2012

Pubmed Data : Cell Biochem Biophys. 2012 Jul ;63(3):247-59. PMID: 22565590
Article Published Date : Jun 30, 2012
Study Type : Commentary
Additional Links
Substances : Sulforaphane
Diseases : Glioma
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

"Sulforaphane and related mustard oils in focus of cancer prevention and therapy."Dec 06, 2012

Pubmed Data : Wien Med Wochenschr. 2012 Dec 7. Epub 2012 Dec 7. PMID: 23224634
Article Published Date : Dec 06, 2012
Study Type : Review
Additional Links
Substances : Cruciferous Vegetables, Mustard Oil, Sulforaphane
Diseases : Cancer Stem Cells
[+]

"Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90."Nov 30, 2012

Pubmed Data : J Nutr Biochem. 2012 Dec ;23(12):1617-26. Epub 2012 Mar 23. PMID: 22444872
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
[+]

"Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways."Oct 31, 2012

Pubmed Data : Oncol Rep. 2012 Nov ;28(5):1851-8. Epub 2012 Aug 22. PMID: 22922937
Article Published Date : Oct 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Multiple Myeloma
Pharmacological Actions : Chemosensitizer
[+]

"Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells."Jan 01, 2011

Pubmed Data : Front Biosci (Elite Ed). 2011 ;3:515-28. Epub 2011 Jan 1. PMID: 21196331
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancer Stem Cells, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Cancer Stem Cells, Drug Synergy
[+]

21 hTERT down-regulation by HDAC1 inhibition is a promising approach for delaying or preventing colorectal cancer.Feb 04, 2017

Pubmed Data : Curr Cancer Drug Targets. 2017 Feb 5. Epub 2017 Feb 5. PMID: 28176652
Article Published Date : Feb 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

A combination of benzyl isothiocyanate and sulforaphane have potent inhibitory activity in pancreatic cancer cells.Dec 01, 2002

Pubmed Data : Int J Cardiol. 2002 Dec;86(2-3):317-23. PMID: 19712481
Article Published Date : Dec 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : Natural Substance Synergy
[+]

A combination of phenethyl isothiocyanate and TH588 has potential as a novel therapeutic strategy against pancreatic cancer.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Mar ;15(3):3240-3244. Epub 2017 Dec 29. PMID: 29435064
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
[+]

A natural compound from Wasabia japonica inhibited the viability of human chronic myelogenous leukemia K562 cells.Nov 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Nov 23 ;9(12). Epub 2019 Nov 23. PMID: 31771225
Article Published Date : Nov 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Wasabi
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Antiproliferative , Autophagy Up-regulation, Cell cycle arrest
[+]

A review evaluating the modulation of miRNAs by dietary agents, which could potentially be exploited for inhibition of mutagenesis and carcinogenesis.Sep 30, 2012

Pubmed Data : Mutat Res. 2012 Oct-Dec;751(2):287-303. Epub 2012 Jun 7. PMID: 22683846
Article Published Date : Sep 30, 2012
Study Type : Review
Additional Links
Substances : Isoflavones, Isothiocyanates, Phospholipids, Polyphenols, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, MicroRNA modulator
Additional Keywords : Epigenetic Modification
[+]

A review of in vitro and vivo antihepatocarcinogenic effects of natural compounds. Jul 31, 2011

Pubmed Data : Clin J Gastroenterol. 2011 Aug ;4(4):185-97. Epub 2011 Jun 4. PMID: 26189518
Article Published Date : Jul 31, 2011
Study Type : Review
Additional Links
Substances : Caffeine, Capsaicin, Cinnamaldehyde, Curcumin, Diallyl sulfide, EGCG (Epigallocatechin gallate), Genistein, Lycopene, Resveratrol, Silymarin, Sulforaphane, Xanthohumol
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

A review of the cardioprotective potential of plant-derived molecules.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819852243. Epub 2019 May 26. PMID: 31205459
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Catechin , Diosgenin, Isoflavones, Quercetin, Sulforaphane
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

A review of the role of phytochemicals in cancer prevention.Oct 08, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 9 ;20(20). Epub 2019 Oct 9. PMID: 31600949
Article Published Date : Oct 08, 2019
Study Type : Review
Additional Links
Substances : Benzyl isothiocyanate , Capsaicin, Catechin , Cucurbitacin B , Isoflavones, Lycopene, Phenethyl isothiocyanate, Piperlongumine
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents
[+]

A variety of natural compounds may inhibit cancer stem cells. Sep 01, 2011

Pubmed Data : J Nutr Biochem. 2011 Sep ;22(9):799-806. Epub 2011 Feb 4. PMID: 21295962
Article Published Date : Sep 01, 2011
Study Type : Review
Additional Links
Substances : Carotenoids, Catechin , Curcumin, Isoflavones, Lycopene, Piperidines, Resveratrol, Stilbenes, Sulforaphane
Diseases : Cancer Stem Cells
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Activity of allyl isothiocyanate and Its synergy with fluconazole against Candida albicans biofilms.Apr 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2017 Apr 28 ;27(4):685-693. PMID: 28138121
Article Published Date : Apr 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
Additional Keywords : Bacterial Infections: Resistance/Biofilm Formation, Natural Substance/Drug Synergy
[+]

Allyl isothiocyanate ameliorates insulin resistance through the regulation of mitochondrial function.Sep 30, 2014

Pubmed Data : J Nutr Biochem. 2014 Oct ;25(10):1026-34. Epub 2014 Jun 5. PMID: 25034503
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.Sep 15, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2011 Sep 16 ;286(37):32259-67. Epub 2011 Jul 21. PMID: 21778226
Article Published Date : Sep 15, 2011
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Allyl isothiocyanate as a cancer chemopreventive phytochemical.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2010 Jan ;54(1):127-35. PMID: 19960458
Article Published Date : Dec 31, 2009
Study Type : Review
Additional Links
Substances : Isothiocyanates
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Phytotherapy
[+]

Allyl isothiocyanate induces autophagy through the up-regulation of beclin-1 in human prostate cancer cells.Oct 03, 2018

Pubmed Data : Am J Chin Med. 2018 Oct 4:1-19. Epub 2018 Oct 4. PMID: 30284468
Article Published Date : Oct 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Prostate Cancer
Pharmacological Actions : Autophagy Up-regulation, Chemotherapeutic
[+]

Allyl isothiocyanate induces cell toxicity by multiple pathways in human breast cancer cells.Dec 31, 2015

Pubmed Data : Am J Chin Med. 2016 ;44(2):415-37. PMID: 27080949
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic
[+]

Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells.Oct 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2010 Nov-Dec;3(6):1023-30. Epub 2010 Sep 15. PMID: 21472349
Article Published Date : Oct 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Chemotherapeutic
[+]

Allyl isothiocyanate inhibits the proliferation of renal carcinoma cell line GRC-1Nov 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2016 Nov 10 ;22:4283-4288. Epub 2016 Nov 10. PMID: 27834342
Article Published Date : Nov 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Allyl isothiocyanate may be beneficial in the treatment of human colorectal adenocarcinoma in the future.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2014 Jan ;31(1):189-96. Epub 2013 Nov 20. PMID: 24270601
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Cancer Metastasis, Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Allyl isothiocyanate nanoparticles have potential as therapeutic agents for bladder cancer and the enhancement of immune function.Mar 31, 2019

Pubmed Data : J Sci Food Agric. 2019 Apr ;99(6):3106-3116. Epub 2019 Jan 25. PMID: 30516283
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Immunomodulatory
Additional Keywords : Isothiocyanates
[+]

Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease.Feb 14, 2020

Pubmed Data : Life Sci. 2020 Feb 15 ;243:117291. Epub 2020 Jan 9. PMID: 31927049
Article Published Date : Feb 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells.Jul 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2010 Aug ;24(2):449-55. PMID: 20596632
Article Published Date : Jul 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis.Dec 31, 2017

Pubmed Data : Mol Cell Biochem. 2018 Jan ;437(1-2):1-12. Epub 2017 Jun 5. PMID: 28585088
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Nrf2 activation
[+]

Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion.Nov 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2010 Dec ;31(12):2105-10. Epub 2010 Oct 1. PMID: 20889681
Article Published Date : Nov 30, 2010
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer, Cancer Metastasis
Pharmacological Actions : Antiproliferative
[+]

Alyssin and iberin in cruciferous vegetables exert anticancer activity in HepG2 by increasing intracellular reactive oxygen species.Aug 12, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2019 Aug 13. Epub 2019 Aug 13. PMID: 31405267
Article Published Date : Aug 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cruciferous Vegetables, Isothiocyanates
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Anti-rheumatic activity of phenethyl isothiocyanate via inhibition of histone deacetylase-1.May 31, 2020

Pubmed Data : Chem Biol Interact. 2020 Jun 1 ;324:109095. Epub 2020 Apr 11. PMID: 32289289
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Antiobesity effects of phytochemicals from an epigenetic perspective.Dec 20, 2020

Pubmed Data : Nutrition. 2020 Dec 21 ;84:111119. Epub 2020 Dec 21. PMID: 33476999
Article Published Date : Dec 20, 2020
Study Type : Review
Additional Links
Substances : Curcumin, Genistein, Isothiocyanates
Diseases : Obesity
Pharmacological Actions : Antioxidants
Additional Keywords : Anti-Obesity Agents, Epigenetic Modification
[+]

Aqueous extract of glucoraphanin-rich broccoli sprouts inhibits formation of advanced glycation end products and attenuates inflammatory reactions.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:9823141. Epub 2018 Aug 8. PMID: 30174716
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells.Mar 31, 2016

Pubmed Data : Oncol Rep. 2016 Apr ;35(4):2089-96. Epub 2016 Jan 19. PMID: 26781422
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Gene Expression Regulation, Isothiocyanates
[+]

Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis.Feb 28, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Feb 29 ;393:114941. Epub 2020 Feb 29. PMID: 32126212
Article Published Date : Feb 28, 2020
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation
[+]

Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):832-840. Epub 2017 Jul 27. PMID: 28766686
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression in T lymphocytic leukemia cells.Apr 17, 2018

Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 18:e22054. Epub 2018 Apr 18. PMID: 29667773
Article Published Date : Apr 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Acute T cell Leukemias
Pharmacological Actions : Chemotherapeutic, interleukin-13 down-regulation
[+]

benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. Jun 30, 2016

Pubmed Data : Vojnosanit Pregl. 2016 Jul ;73(7):636-42. PMID: 29314795
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate downregulated the expression of virulence factors in staphylococcus aureus.Oct 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 31 ;20(21). Epub 2019 Oct 31. PMID: 31683671
Article Published Date : Oct 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Antiviral Agents
[+]

Benzyl isothiocyanate induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells.Nov 30, 2016

Pubmed Data : Environ Toxicol. 2016 Dec ;31(12):1751-1760. Epub 2015 Sep 7. PMID: 28675694
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces apoptotic cell death in gefitinib-resistant NCI-H460 lung cancer cells.Aug 31, 2018

Pubmed Data : Anticancer Res. 2018 Sep ;38(9):5165-5176. PMID: 30194164
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate induces reactive oxygen species-initiated autophagy and apoptosis in human prostate cancer cells.Mar 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Mar 21 ;8(12):20220-20234. PMID: 28423628
Article Published Date : Mar 20, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate inhibits breast cancer cell tumorigenesisDec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(10):17601-11. Epub 2015 Oct 15. PMID: 26770350
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPS-stimulated BV2 cells.Aug 31, 2016

Pubmed Data : Int J Mol Med. 2016 Sep ;38(3):912-8. Epub 2016 Jul 6. PMID: 27430883
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate is a potential therapeutic approach for oral squamous cell carcinoma.Apr 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2019 Apr 8 ;52(4):e8409. Epub 2019 Apr 8. PMID: 30970087
Article Published Date : Apr 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage response.Oct 31, 2016

Pubmed Data : Food Chem Toxicol. 2016 Nov ;97:336-345. Epub 2016 Sep 28. PMID: 27693243
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Oral Cancer, Oxidative Stress
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Isothiocyanates
[+]

Benzyl isothiocyanate promotes miR-99a expression through ERK/AP-1-dependent pathway in bladder cancer cells.Oct 05, 2019

Pubmed Data : Environ Toxicol. 2019 Oct 6. Epub 2019 Oct 6. PMID: 31587482
Article Published Date : Oct 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Bladder Cancer
Pharmacological Actions : Chemotherapeutic, MicroRNA modulator
[+]

Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells.May 31, 2019

Pubmed Data : Int J Oncol. 2019 Jun ;54(6):2106-2116. Epub 2019 Mar 26. PMID: 30942430
Article Published Date : May 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, MicroRNA modulator
[+]

Benzyl isothiocyanate triggers apoptosis in gastric adenocarcinoma cells.Dec 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2019 Dec 6 ;9(12). Epub 2019 Dec 6. PMID: 31817791
Article Published Date : Dec 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic
[+]

Benzyl-isothiocyanate induces apoptosis and inhibits migration and invasion of hepatocellular carcinoma cells in vitro.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2017 ;8(2):240-248. Epub 2017 Jan 15. PMID: 28243328
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Survivin Down-Regulation
[+]

Beta-phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38.Jun 30, 2012

Pubmed Data : Oral Dis. 2012 Jul ;18(5):513-9. Epub 2012 Feb 6. PMID: 22309674
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Beta-Phenethyl isothiocyanate is a promising compound for potential use in leukemia treatment.Dec 14, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2011 Dec 15 ;15(12):2911-21. Epub 2011 Sep 29. PMID: 21827296
Article Published Date : Dec 14, 2011
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antineoplastic Agents
[+]

Beta-phenethyl isothiocyanate promotes neurite growth in primary sensory neurons.Dec 31, 2018

Pubmed Data : J Drug Target. 2019 Jan ;27(1):82-93. Epub 2018 Sep 5. PMID: 29877111
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : MicroRNA modulator, Neuritogenic
[+]

Beta-phenylethyl isothiocyanate and curcumin work synergistically to inhibit prostate cancer cell signaling.Aug 01, 2006

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31. PMID: 16299382
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Isothiocyanates, Natural Substance Synergy

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