Medicinal Mushrooms

Name	AC	CK
Cancers: All	24	71
Breast Cancer	35	57
Diabetes Mellitus: Type 2	24	52
Inflammation	17	50
Liver Cancer	18	48
Oxidative Stress	21	44
Colon Cancer	20	35
Lung Cancer	18	30
Diabetes Mellitus: Type 1	7	26
Fatigue	5	26
Cancer Metastasis	7	24
Prostate Cancer	13	24
Alzheimer's Disease	12	23
Cervical Cancer	7	20
Hepatitis B	2	20
Herpes Zoster	2	20
Shingles	2	20
Chemically-Induced Liver Damage	10	19
Chemotherapy-Induced Toxicity	6	19
Insulin Resistance	5	18
Radiation Induced Illness	4	18
Breast Cancer: Triple Negative	11	16
Bladder Cancer	6	15
Depression	4	15
Lipid Peroxidation	5	14
Melanoma	8	14
Aging	8	12
Asthma	2	12
Cognitive Decline/Dysfunction	2	12
Gastric Cancer	9	12
Leukemia	11	12
Ovarian Cancer	3	12
Parkinson's Disease	7	12
Anxiety Disorders	2	11
Carcinoma: Non-Small-Cell Lung	9	11
DNA damage	5	11
Glioma	5	11
Neurodegenerative Diseases	7	11
Prostatic Hyperplasia: Benign	2	11
Tumors	6	11
Breast Cancer: Prevention	1	10
C-Reactive Protein	1	10
COPD	1	10
Chemotherapy-Induced Toxicity: Cisplatin	6	10
Cold Sore	1	10
Colitis	5	10
Depressive Disorder	1	10
Diabetes: Cardiovascular Illness	1	10
Diabetic Complications	5	10
Endometrial Cancer	1	10
Focal segmental glomerulosclerosis (FSGS)	1	10
HSV-2	1	10
Herpes Genitalis	1	10
Inflammatory Bowel Diseases	5	10
Kidney Diseases	1	10
Kidney Failure	1	10
Lupus Nephritis	1	10
Myelodysplastic Syndromes	1	10
Organ Transplantation: Kidney	1	10
Post-Herpetic Neuralgia	1	10
Quality of Life: Poor	1	10
Weight Probems: Appetite	1	10
Atherosclerosis	4	9
Colorectal Cancer	6	9
Dementia	5	9
Hyperglycemia	5	9
Immune Disorders: Low Immune Function	5	9
Lipopolysaccharide-Induced Toxicity	7	9
Alcohol Toxicity	4	8
Gastric Ulcer	5	8
HIV Infections	8	8
High Cholesterol	4	8
High Fat Diet	4	8
Hypercholesterolemia	4	8
Immune Dysregulation: TH1/TH2 imbalance	5	8
Influenza A	5	8
Liver Cirrhosis	4	8
Osteoporosis	2	8
Hydrogen Peroxide Induced Toxicity	3	7
Obesity	4	7
Breast Cancer: Metastatic	3	6
Cadmium Poisoning	3	6
Chemotherapy and Radiation Toxicity	3	6
Hyperlipidemia	3	6
Memory Disorders	3	6
Myelotoxicity	3	6
Pancreatitis	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Cholangiocarcinoma	1	5
Crohn's Disease	1	5
H1N1 Infection	3	5
Kidney Cancer	3	5
Lymphoma	4	5
Multiple Myeloma	4	5
Triglycerides: Elevated	3	5
Acute Myeloid Leukemia	3	4
Allergies	2	4
Anxiety	2	4
Arteriosclerosis	2	4
Arthritis	1	4
Brain Inflammation	3	4
Cancers: Multi-Drug Resistant	3	4
Cerebral Ischemia	2	4
Chemotherapy Induced Myelotoxicity	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	2	4
Glioblastoma	1	4
Hair Loss	2	4
High Cholesterol: very low density lipoprotein (VLDL)	2	4
Hypertension	2	4
Hypoxia	3	4
Liver Disease	2	4
Low Immune Function: Natural Killer Cells	2	4
Pseudomonas aeruginosa	4	4
Sepsis	2	4
Skin Cancer	2	4
Cardiovascular Diseases	2	3
Diabetes: Oxidative Stress	2	3
Dyslipidemias	2	3
Hepatitis C	2	3
Herpes Simplex Virus Type 1	3	3
Ischemia	2	3
Laryngeal Cancer	1	3
Organ Transplantation	2	3
Sarcoidosis	1	3
Ultraviolet Radiation Induced Damage	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging Skin	1	2
Aging: Brain	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Amyloid toxicity	1	2
Amyloid β peptide toxicity	1	2
Anaphylactic Reaction	1	2
Androgen-Induced Diseases	2	2
Animal Cancers	1	2
Arrhythmias: Cardiac	1	2
Asthma: Bronchial	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Brain: Microglial Activation	1	2
Breast Cancer: Drug Resistant	2	2
Breast Cancer: Inflammatory	1	2
Cachexia	1	2
Candida Albicans	2	2
Candidiasis	1	2
Cat Diseases	1	2
Cataract	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chemotherapy-Induced Toxicity: Mitomycin-C	1	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Chronic Kidney Disease (CKD)	1	2
Chronic Pain	1	2
Citrobacter Infection	1	2
Colon Cancer: Prevention	1	2
Coronary Artery Disease	1	2
Cysts	1	2
Depression	1	2
Diabetic Nephropathy	1	2
Diabetic Neuropathy	1	2
Duodenal Ulcer	1	2
Dysthymic Disorder	1	2
Enterobacteriaceae Infections	1	2
Epstein-Barr Virus Infections	2	2
Escherichia coli Infections	2	2
Fatty Liver	1	2
Food Allergies	1	2
Gastric Ulcers	1	2
Gastrointestinal Inflammation	1	2
H3N2 Infection	1	2
H5N1 Infection	1	2
HSV-1	1	2
Hepatic Steatosis	1	2
Hepatoma	2	2
Human Flu	1	2
Human Influenza	1	2
Hyperinsulinism	1	2
Hypertension: Portal	1	2
Hyperuricemia	1	2
Hypoglycemia	1	2
Infertility: Male	1	2
Ischemia: Myocardial	1	2
Kidney Fibrosis	1	2
Klebsiella Infections	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia: Monocytic	2	2
Lipid Metabolism: Abnormalities	1	2
Listeria Infections	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Immune Function: Splenic Dysfunction	1	2
Low Immune Function: Thymus Dysfunction	1	2
Low Libido	1	2
Lupus Erythematosus: Systemic	1	2
Malaria	1	2
Metabolic Syndrome X	1	2
Mycobacterium tuberculosis	1	2
Neurologic Disorders	2	2
Neutropenia	2	2
Neutropenia: Chemotherapy Induced	2	2
Neutropenia: Cyclic	2	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation: Skin	1	2
Pancreatitis: Chronic	1	2
Peripheral Nerve Diseases	1	2
Polycystic Kidney Diseases	1	2
Progesterone: Low	1	2
Promyelocytic leukemia	2	2
Pulmonary Cancer	1	2
Pulmonary Fibrosis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiation Induced Illness: Enteritis	1	2
Sexual Arousal Disorder	1	2
Sexual Dysfunction	1	2
Staphylococcus aureus infection	2	2
Staphylococcus epidermidis	2	2
Stomach Cancer	2	2
Streptococcus Infections	1	2
Streptococcus infections: Group A	1	2
Stress	1	2
Swine Flu Associated Virus	1	2
Systemic Lupus Erythematosus	1	2
Testicular Injury: Cadmium-Induced	1	2
Thrombosis	2	2
Thymic Dysplasia	1	2
Toxoplasma gondii Infection	1	2
Ulcerative Colitis	1	2
Water Retention	1	2
West Nile Fever	1	2
Wound Healing	1	2
Adrenal Gland Diseases	1	1
Adrenal Gland: Enhanced Apoptosis	1	1
Arthritis: Rheumatoid	2	1
Aspergillosis	1	1
Bacillus subtilis infections	1	1
Bacterial Infections and Mycoses	1	1
Brain Hypoxia	1	1
Breast Cancer: Lung Metastasis	1	1
Cancers: Canine	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Small Cell Lung	1	1
Chemotherapy	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Myeloid Leukemia	1	1
Clotting	1	1
Cryptococcosis	1	1
Cystic Fibrosis	1	1
Demyelinating Diseases	1	1
Dry Skin	1	1
Epilepsy	1	1
Epithelial Neoplasms: Malignant	1	1
Fungal Infection	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
Helicobacter Pylori Infection	1	1
Hepatoma: Multidrug Resistant	1	1
Infant Acute Monocytic Leukemia	1	1
Influenza	1	1
Larynx Neoplasms	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukopenia: Chemotherapy Induced	1	1
Malignant Melanoma	1	1
Melanoma: Metastatic	1	1
Micrococcus luteus infections	1	1
Neurological Conditions	1	1
Neutropenia: Severe Congenital	1	1
Osteosarcoma	1	1
Pancreatic Cancer	1	1
Pigmentation Disorders	1	1
Pulmonary Hypertension	1	1
Radiation Disaster Associated Toxicity	1	1
Sarcoma	1	1
Testosterone-Induced	1	1
Tuberculosis	1	1
Vitamin B 12 Deficiency	1	1
Vitamin D Deficiency	1	1

Name	AC	CK
Antioxidants	88	178
Antiproliferative	74	132
Anti-Inflammatory Agents	50	116
Apoptotic	69	113
Immunomodulatory	45	106
Hypoglycemic Agents	26	57
Hepatoprotective	23	50
Neuroprotective Agents	29	47
Antineoplastic Agents	25	45
Cell cycle arrest	28	43
Chemopreventive	15	39
Tumor Necrosis Factor (TNF) Alpha Inhibitor	21	39
Immunostimulatory	11	37
NF-kappaB Inhibitor	19	30
Anti-metastatic	15	28
Antifungal Agents	7	27
Anti-Apoptotic	14	26
Hypolipidemic	13	26
Chemotherapeutic	13	23
Interleukin-1 beta downregulation	12	23
Interleukin-6 Downregulation	12	20
Antiviral Agents	14	19
Malondialdehyde Down-regulation	9	17
Antidepressive Agents	4	16
Anti-Bacterial Agents	13	15
Cardioprotective	9	15
Superoxide Dismutase Up-regulation	8	15
Analgesics	3	14
Cyclooxygenase 2 Inhibitors	10	14
Cytotoxic	11	14
Interleukin-10 upregulation	3	14
Bcl-2 protein down-regulation	6	12
Interferon-gamma (IFN-gamma) inducer	2	12
Anticholesteremic Agents	6	11
Chemoprotective Agents	6	11
Nitric Oxide Inhibitor	4	11
Anxiolytic	1	10
Autophagy Up-regulation	4	10
Gastrointestinal Agents	5	10
Interleukin-4 upregulation	1	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	10
Gastroprotective	5	9
Neuritogenic	7	9
Radioprotective	4	9
Alpha-glucosidase inhibitor	6	8
Cyclin D1 Down-Regulation	3	8
Osteoprotective	2	8
Anti-Tumor	4	7
Anticarcinogenic Agents	4	7
Caspase-3 Activation	4	7
Chemosensitizer	5	7
P21 Activation	3	7
Renoprotective	4	7
Tumor Suppressor Protein p53 Upregulation	7	7
Antimutagenic Agents	2	6
Interleukin-12 upregulation	4	6
Nrf2 activation	4	6
Osteogenic	1	6
Pancreato Protective Agents	4	6
Anti-Ulcer Agents	3	5
Antihypertensive Agents	3	5
Caspase-9 Activation	3	5
MicroRNA modulator	4	5
Angiogenesis Inhibitors	2	4
Anti-Angiogenic	3	4
Anti-Anxiety Agents	2	4
Anti-HIV Agents	4	4
Anti-atherogenic	2	4
Antinoceceptive	2	4
Aromatase Inhibitors	3	4
Catalase Up-Regulation	2	4
Enzyme Inhibitors	2	4
Interleukin-4 downregulation	2	4
Neurogenesis	2	4
Prophylactic Agents	2	4
Radiation-Protective Agents	2	4
Antimicrobial	3	3
Heme oxygenase-1 up-regulation	2	3
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	3
Neurominidase Inhibitor	2	3
Tumor Necrosis Factor (TNF) Alpha Enhancer	2	3
5-Lipoxygenase Inhibitor	1	2
5-alpha reductase inhibitor	2	2
Acetylcholinesterase Inhibitor	2	2
Alpha-amylase inhibitor	2	2
Anti-Allergic Agents	1	2
Aphrodisiac	1	2
Bax/Bcl2 ratio: Increase	1	2
Bcl-xL down-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-8 activation	1	2
Cytoprotective	1	2
Diuretics	1	2
Genoprotective	2	2
Glutathione Upregulation	1	2
Heat Shock Protein Down-Regulation	1	2
Hematopoietic	2	2
Interferon Gamma Reducer	1	2
Interleukin-1 beta upregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-6 upregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	2
Nitric Oxide Enhancer	2	2
Platelet Aggregation Inhibitors	2	2
Protein tyrosine phosphatase 1B (PTP1B) modulator	1	2
Regenerative	1	2
Secretagogue	1	2
Telomerase Inhibitor	2	2
Topoisomerase I inhibitor	1	2
Topoisomerase II Inhibitor	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
interleukin-13 down-regulation	1	2
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Infective Agents	1	1
Anti-Platelet	1	1
Antimycobacterial	1	1
Autophagy Inhibitors	1	1
Cyclooxygenase Inhibitors	1	1
Estrogen Receptor Modulators	1	1
Gene Protective	1	1
HIV Protease Inhibitors	1	1
Interferon Inducers	1	1
Interleukin-10 downregulation	1	1
Interleukin-18 upregulation	1	1
Interleukin-8 downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
Photoprotective	1	1
Platelet aggregation inhibitor: collagen-induced aggregation	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1
Tyrosinase inhibitors	1	1
Wnt/β-catenin pathway down-regulation	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

S. crispa extracts are useful for prevention and treatment of human diseases.May 15, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Chin Med. 2005;33(4):517-23. PMID: 16173526

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Reishi Mushroom

Diseases : Herpes Zoster, Shingles

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Agaricus blazei extract in combination with metformin and gliclazide improve insulin resistance in type 2 diabetics. Dec 01, 1999

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Pubmed Data : J Surg Oncol. 1999 Dec;72(4):230-9. PMID: 17309383

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Pubmed Data : Int J Med Mushrooms. 2015 ;17(9):799-817. PMID: 26756293

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Pubmed Data : Int J Cancer. 2009 Mar 15;124(6):1404-8. PMID: 19048616

Article Published Date : Mar 15, 2009

Study Type : Human Study

Additional Links

Substances : Green Tea, Mushrooms: All

Diseases : Breast Cancer: Prevention, Cancer Metastasis

Pharmacological Actions : Chemopreventive

Additional Keywords : Risk Reduction

[+]

Dongchongxiacao (Cordyceps) can reduce serum markers of airway inflammation of asthmatics.Sep 01, 2005

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Pubmed Data : J Hypertens. 2005 Sep;23(9):1699-706. PMID: 17972591

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Asthma, COPD

[+]

Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:7861297. Epub 2019 Apr 18. PMID: 31118969

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Obesity, Overweight , Sleep Disorders

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents, Brain-derived neurotrophic factor modulator

[+]

Hericium erinaceus intake results in a reduction of depression and anxiety in mice by 4 weeks. Aug 01, 2010

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Pubmed Data : Biomed Res. 2010 Aug ;31(4):231-7. PMID: 20834180

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Pubmed Data : Mymensingh Med J. 2007 Jan;16(1):94-9. PMID: 17344789

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Oyster Mushroom

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 1

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Plant Extracts

[+]

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

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Pubmed Data : J Am Coll Nutr. 2015 ;34(6):478-87. Epub 2015 Apr 11. PMID: 25866155

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Pubmed Data : Psychiatry Res. 2015 Jul 15. Epub 2015 Jul 15. PMID: 26208984

Pubmed Data : Int J Med Mushrooms. 2018 ;20(8):705-716. PMID: 30317947

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Beta-glucan, Reishi Mushroom, Yoghurt

Pharmacological Actions : Immunomodulatory

[+]

Click here to read the entire abstract

Pubmed Data : Inflamm Bowel Dis. 2015 May 19. Epub 2015 May 19. PMID: 25993687

Article Published Date : May 18, 2015

Study Type : Human In Vitro

Additional Links

Substances : Reishi Mushroom

Diseases : Crohn's Disease

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

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Pubmed Data : J Sci Food Agric. 2010 Jan 30 ;90(2):276-80. PMID: 20355042

Article Published Date : Jan 29, 2010

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation

Additional Keywords : Plant Extracts

[+]

A fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy.Dec 31, 2016

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Pubmed Data : Front Immunol. 2017 ;8:666. Epub 2017 Jun 12. PMID: 28713364

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Pubmed Data : Int J Med Mushrooms. 2015 ;17(11):1055-60. PMID: 26853960

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents

Additional Keywords : Plant Extracts

[+]

A polysaccharide from Pleurotus nebrodensis might be a promising candidate for preventing hepatic I/R injury.Nov 30, 2017

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Pubmed Data : Int J Biol Macromol. 2017 Dec ;105(Pt 1):447-451. Epub 2017 Jul 11. PMID: 28709897

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Oncol Rep. 2006 Dec;16(6):1181-7. PMID: 17089035

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Lung Cancer, Pulmonary Cancer

[+]

A water-soluble polysaccharide from chaga mushroom had potential as a natural antitumor agent with immunomodulatory activity.Sep 30, 2012

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Pubmed Data : Carbohydr Polym. 2012 Oct 1 ;90(2):870-4. Epub 2012 Jun 17. PMID: 22840014

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Gastric Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Immunomodulatory

Additional Keywords : Plant Extracts

[+]

A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

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Pubmed Data : Pak J Biol Sci. 2014 Sep ;17(9):1079-82. PMID: 26031030

Article Published Date : Aug 31, 2014

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Pubmed Data : Int J Med Mushrooms. 2016 ;18(2):123-32. PMID: 27279534

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Agaricus brasiliensis

Pharmacological Actions : Immunostimulatory, Interleukin-1 beta upregulation, Interleukin-6 upregulation

Additional Keywords : Polysaccharides

[+]

Acetic acid and Reishi mushroom polysaccharide contain lifespan-promoting activity in the nematode. Nov 15, 2009

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Pubmed Data : Bioorg Med Chem.2009 Nov 15;17(22):7831-40. Epub 2009 Sep 6. PMID: 19837596

Article Published Date : Nov 15, 2009

Study Type : Animal Study

Additional Links

Substances : Acetic Acid, Reishi Mushroom

Diseases : Aging

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[+]

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Pubmed Data : J Appl Physiol. 2003 Aug;95(2):491-6. Epub 2003 Apr 11. PMID: 12692142

Article Published Date : Aug 01, 2003

Study Type : Animal Study

Additional Links

Substances : AHCC

Diseases : Klebsiella Infections

Additional Keywords : Space Flight

[+]

AHCC enhances the immune function of mice in a model of spaceflight conditions. Oct 01, 2004

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Pubmed Data : J Appl Physiol. 2004 Oct;97(4):1437-44. Epub 2004 Jun 11. PMID: 15194672

Pubmed Data : J Exp Ther Oncol. 2009;8(1):43-51. PMID: 19827270

Article Published Date : Jan 01, 2009

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : PLoS One. 2013 ;8(2):e57431. Epub 2013 Feb 28. PMID: 23468988

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Breast Cancer, Breast Cancer: Inflammatory, Inflammation

Pharmacological Actions : Anti-Tumor

[+]

Anticancer activity of Cynomorium coccineum.Sep 25, 2018

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Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs

[+]

Chaga mushroom and its compounds could be used as natural anticancer ingredients.May 31, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res Pract. 2010 Jun ;4(3):177-82. Epub 2010 Jun 29. PMID: 20607061

Article Published Date : May 31, 2010

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Breast Cancer, Carcinoma: Non-Small-Cell Lung, Cervical Cancer, Gastric Cancer

Pharmacological Actions : Antiproliferative

[+]

Chaga mushroom extract significantly reduced the total IgE levels in mice and slightly affected the production of IgG1.Mar 31, 2013

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Pubmed Data : Int Immunopharmacol. 2013 Apr ;15(4):666-70. Epub 2013 Mar 25. PMID: 23535020

Continuous intake of the I. obliquus extract could suppress tumor progression.Apr 30, 2016

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Pubmed Data : Heliyon. 2016 May ;2(5):e00111. Epub 2016 May 12. PMID: 27441282

Article Published Date : Apr 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

[+]

Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway.Feb 17, 2019

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Pubmed Data : Life Sci. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30790609

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Pubmed Data : Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. PMID: 19596425

Cordyceps mycelia may ameliorate chemically induced liver cirrhosis. Sep 01, 2009

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Sep;29(9):810-5. PMID: 19960979

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Liver Cirrhosis

Pharmacological Actions : Hepatoprotective

[+]

Cordyceps mycelia may decrease portal hypertension in rats with chemically induced liver cirrhosis. Nov 01, 2008

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Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2008 Nov;6(11):1136-44. PMID: 18990339

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Pubmed Data : Mol Chem Neuropathol. 1998 Feb;33(2):139-48. PMID: 16014434

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Pubmed Data : Int J Med Mushrooms. 2016 ;18(3):227-34. PMID: 27481156

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Fermented Cordyceps sinensis can ameliorate the oxidative stress in Doxorubicin treated rats.Sep 30, 2015

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Pubmed Data : Food Nutr Res. 2019 ;63. Epub 2019 Feb 12. PMID: 30814921

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Colitis

Pharmacological Actions : Gastrointestinal Agents

[+]

Ganoderma lucidum polysaccharide peptide alleviates hepatoteatosis.Dec 31, 2017

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Pubmed Data : Cell Physiol Biochem. 2018 ;49(3):1163-1179. Epub 2018 Sep 7. PMID: 30196282

Article Published Date : Dec 31, 2017

Study Type : Transgenic Animal Study

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Substances : Reishi Mushroom

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Polysaccharides

[+]

Ganoderma lucidum polysaccharides inhibited hepatocellular carcinoma proliferation through inhibiting miR-125b and inhibiting tregs accumulation and function.Dec 31, 2014

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Pubmed Data : J Transl Med. 2015 ;13:100. Epub 2015 Mar 26. PMID: 25889022

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Liver Cancer, Liver Cancer: Prevention

Pharmacological Actions : Antiproliferative , Chemotherapeutic, MicroRNA modulator

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2016 Nov 1 ;17(11). Epub 2016 Nov 1. PMID: 27809277

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:418023. Epub 2015 Apr 16. PMID: 25960751

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Alcohol Toxicity

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Hericium erinaceus treatment along with the antioxidant activity could be the probable way by which it had alleviated diabetic neuropathy.Dec 31, 2014

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:595480. Epub 2015 Apr 16. PMID: 25960754

Inonotus obliquus polysaccharide has strong activity for ameliorating chronic pancreatitis and a beneficial effect on gut microbiota.Nov 30, 2017

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Pubmed Data : AMB Express. 2017 Dec ;7(1):39. Epub 2017 Feb 14. PMID: 28197985

Pharmacological Actions : Antiproliferative

Additional Keywords : Drug-Plant-Vitamin Synergies, Drug Side Effect Attenuation

[+]

Maitake D-Fraction Pro4X prevents breast carcinogenesis, blocks tumor invasiveness, reduces angiogenesis, and increases overall survival.Jul 10, 2016

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Pubmed Data : Exp Biol Med (Maywood). 2016 Mar 24. Epub 2016 Mar 24. PMID: 27013543

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Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:865986. Epub 2015 Apr 6. PMID: 25945116

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Cerebral Ischemia, Diabetes Mellitus: Type 2, Hypoxia

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents

[+]

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Pubmed Data : Biosci Biotechnol Biochem. 2017 Jun 29:1-9. Epub 2017 Jun 29. PMID: 28661219

Article Published Date : Jun 28, 2017

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Chemopreventive, Gastrointestinal Agents

Additional Keywords : Microbiota

[+]

Reishi may have therapeutic value in the treatment of Sjogren's syndrome.Mar 05, 2009

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Pubmed Data : Chin Med J (Engl). 2009 Mar 5;122(5):556-60. PMID: 19323907

Article Published Date : Mar 05, 2009

Study Type : Animal Study

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Substances : Reishi Mushroom

Pharmacological Actions : Apoptotic

[+]

Reishi mushroom extract demonstrated cardioprotective properties through antioxidant effects. Mar 31, 2015

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Pubmed Data : Bull Exp Biol Med. 2015 Apr ;158(6):739-41. Epub 2015 Apr 22. PMID: 25896590

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Pubmed Data : Food Funct. 2015 Jun ;6(6):2068-80. PMID: 26034783

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S. crispa extracts are useful for prevention and treatment of human diseases.May 15, 2018

A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

A mushroom formula containing Reishi (Ganoderma) has therapeutic activity against herpes genitalis and labialis.Nov 01, 2007

A mushroom formula containing Reishi (Ganoderma) reduces pain in patients with Herpes zoster.Jan 01, 2005

Agaricus blazei extract in combination with metformin and gliclazide improve insulin resistance in type 2 diabetics. Dec 01, 1999

Agaricus blazei extract normalizes liver function in patients withi chronic hepaititis B. Apr 01, 2008

Agaricus blazei increases natural killer cell activity and quality of life in gynecological cancer patients undergoing chemotherapy. Jul 01, 2004

Agaricus brasiliensis has a wide range of therapeutic properties as demonstrated in mice and human subjects. Jun 01, 2008

AHCC improves prognosis of postoperative liver cancer patients. Jul 01, 2002

AHCC may improve survival and prognosis in patients with advanced liver cancer. Mar 01, 2006

Combined therapy of Red sage (S. miltiorrhizae) and Zhu Ling (P. umbellatus) polysaccharide has therapeutic value in the treatment of chronic hepatitis B.Sep 01, 1993

Consumption of Agaricus brasiliensis KA21 for 12 weeks led to many beneficial improvements in health. Dec 31, 2014

Cordyceps and artemisinin prevent the recurrence of lupus nephritis.Mar 01, 2002

Cordyceps may improve renal function and cellular immune function in chronic kidney failure. Jun 01, 1992

Cordyceps may reduce the need for anti-rejection drugs and improve the outcome of renal transplantation. Jun 01, 2009

Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women.Mar 15, 2009

Dongchongxiacao (Cordyceps) can reduce serum markers of airway inflammation of asthmatics.Sep 01, 2005

Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity.Dec 31, 2018

Hericium erinaceus intake results in a reduction of depression and anxiety in mice by 4 weeks. Aug 01, 2010

Lion's mane improves mild cognitive impairment in human subjects. Mar 01, 2009

Mycoprotein and tofu have satiating properties that persist for several hours after a meal.Jan 01, 2006

Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects.Jan 01, 2007

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

Reishi (Ganoderma lucidum) safely improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Sep 01, 2008

Reishi (Ganoderma) has significant therapeutic value in patients with FSGS. Jan 01, 2004

Reishi reduces pain from postherpetic neuralgia. Mar 01, 2006

Results suggest that adherence to a diet rich in vegetables, fruits, and typical Japanese foods is associated with a lower probability of having depressive symptoms.Jul 14, 2015

The mushroom Grifola umbellata is superior to mitomycin C in preventing postoperative recurrence of bladder cancer. Sep 05, 2007

The present intervention demonstrated the antioxidation, anti-aging and hepatoprotective nature of Ganoderma lucidum.Nov 30, 2017

These results found increasingly improved symptom score in the AndoSan group.Dec 31, 2015

This study demonstrates that β-glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood.Dec 31, 2017

White button mushroom appears to both impact PSA levels and modulate the biology of biochemically recurrent prostate cancer.Aug 31, 2015

An extract of G. lucidum spores suppressed cholangiocarcinoma migration in vitro through inhibition of TGF-β1-induced EMT.May 14, 2016

Chaga mushroom extract can inhibit the proliferation of tumor cells.Dec 31, 2013

Combined application of Grifola frondosa and vitamin C induced cell apoptosis and autophagy in vitro.Sep 10, 2017

These preliminary results demonstrated anti-genotoxic properties of Agaricus blazei.Dec 31, 2016

Triterpene ganoderic acid inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation.May 18, 2015

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

A case report of Korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer. Dec 31, 2014

A patient with annular cutaneous sarcoidosis showed almost complete regression of lesions.Feb 29, 2016

A combined mixture of medicinal mushrooms and P. ginseng root extracts could be an adjuvant treatment in human colorectal cancer.Aug 31, 2017

A derived protein fraction from oyster mushroom exhibits anti-tumor properties in Dalton's lymphoma bearing mice. Jan 01, 2011

A fraction from I. obliquus showed significant antihyperglycaemic and antilipidperoxidative effects in alloxan-induced diabetic mice.Jan 29, 2010

A fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy.Dec 31, 2016

A hybridized strain of Cordyceps (Paecilomyces hepiali) may prevent autoimmune diseases like type 1 diabetes by maintaining the dendritic cells in a tolerogenic state. Oct 20, 2005

A mixture of asian herbs increases progesterone secretion in female rats.Jan 01, 1991

A polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.Dec 31, 2014

A polysaccharide from Pleurotus nebrodensis might be a promising candidate for preventing hepatic I/R injury.Nov 30, 2017

A polysaccharide from the mycelia of G. lucidum might be used as functional agent to regulate the intestinal barrier functions.Sep 28, 2016

A polysaccharide, extract from Maitake, induces Th-1 dominant responses in cancer-bearing mice. Dec 01, 2002

A reishi extract ameliorates the colon precancerous lesions induced by AOM and the small-intestinal injury caused by 5-FU.May 31, 2013

A selenium enriched polysaccharide from Grifola frondosa significantly inhibited the growth of Heps tumor in vivo.Dec 31, 2015

A water extract of broken spores of G. lucidum possesses chemopreventive potential in colorectal cancer.Apr 30, 2017

A water extract of Chaga mushroom is a very potent immune modulator that recovers the bone marrow system damaged by chemotherapy.Aug 31, 2005

A water extract of maitake mushroom reduces circulating glucose/insulin concentrations in insulin-resistant mice. Jan 01, 2002

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

A water-soluble extract of Reishi mushroom inhibits the development of lung tumors in rats. Dec 01, 2006

A water-soluble polysaccharide from chaga mushroom had potential as a natural antitumor agent with immunomodulatory activity.Sep 30, 2012

A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

A. blazei extract offers a promising and new therapeutic lead for treatment of Parkinson's disease.Jun 18, 2017

A. brasiliensis and G. lucidum have pronounced antioxidant properties. Dec 31, 2014

A. brasiliensis improves the serum lipid profile in hypercholesterolemic rats May 04, 2016

A. brasiliensis polysaccharides induce a very promising immunostimulation effect in vivo and in vitro. Dec 31, 2015

Acetic acid and Reishi mushroom polysaccharide contain lifespan-promoting activity in the nematode. Nov 15, 2009

Administration of medicinal mushrooms under experimental diabetes showed a positive corrective action on the L-arginine/NO system and the ratio between p53 and Bcl-2 proteins.Dec 31, 2014

Agaricus blazei inhibits myeloma in vivo. Jan 01, 2007

Agaricus blazei Murill polysaccharides inhibited cadmium induced effects on chicken peripheral blood lymphocytes.Oct 31, 2017

Agaricus blazei polysaccharide has a protective effect on cadmium induced damage in chicken spleens.Oct 13, 2017

Agaricus blazei polysaccharide has beneficial effects on cadmium toxicity on peripheral blood lymphocytes.Dec 31, 2017

Medicinal Mushrooms

View the Evidence:
551 Abstracts with Medicinal Mushrooms Research