Medicinal Mushrooms

Name	AC	CK
Cancers: All	24	71
Breast Cancer	35	57
Diabetes Mellitus: Type 2	24	52
Inflammation	17	50
Liver Cancer	18	48
Oxidative Stress	21	44
Colon Cancer	20	35
Lung Cancer	18	30
Diabetes Mellitus: Type 1	7	26
Fatigue	5	26
Cancer Metastasis	7	24
Prostate Cancer	13	24
Alzheimer's Disease	12	23
Cervical Cancer	7	20
Hepatitis B	2	20
Herpes Zoster	2	20
Shingles	2	20
Chemically-Induced Liver Damage	10	19
Chemotherapy-Induced Toxicity	6	19
Insulin Resistance	5	18
Radiation Induced Illness	4	18
Breast Cancer: Triple Negative	11	16
Bladder Cancer	6	15
Depression	4	15
Lipid Peroxidation	5	14
Melanoma	8	14
Aging	8	12
Asthma	2	12
Cognitive Decline/Dysfunction	2	12
Gastric Cancer	9	12
Leukemia	11	12
Ovarian Cancer	3	12
Parkinson's Disease	7	12
Anxiety Disorders	2	11
Carcinoma: Non-Small-Cell Lung	9	11
DNA damage	5	11
Glioma	5	11
Neurodegenerative Diseases	7	11
Prostatic Hyperplasia: Benign	2	11
Tumors	6	11
Breast Cancer: Prevention	1	10
C-Reactive Protein	1	10
COPD	1	10
Chemotherapy-Induced Toxicity: Cisplatin	6	10
Cold Sore	1	10
Colitis	5	10
Depressive Disorder	1	10
Diabetes: Cardiovascular Illness	1	10
Diabetic Complications	5	10
Endometrial Cancer	1	10
Focal segmental glomerulosclerosis (FSGS)	1	10
HSV-2	1	10
Herpes Genitalis	1	10
Inflammatory Bowel Diseases	5	10
Kidney Diseases	1	10
Kidney Failure	1	10
Lupus Nephritis	1	10
Myelodysplastic Syndromes	1	10
Organ Transplantation: Kidney	1	10
Post-Herpetic Neuralgia	1	10
Quality of Life: Poor	1	10
Weight Probems: Appetite	1	10
Atherosclerosis	4	9
Colorectal Cancer	6	9
Dementia	5	9
Hyperglycemia	5	9
Immune Disorders: Low Immune Function	5	9
Lipopolysaccharide-Induced Toxicity	7	9
Alcohol Toxicity	4	8
Gastric Ulcer	5	8
HIV Infections	8	8
High Cholesterol	4	8
High Fat Diet	4	8
Hypercholesterolemia	4	8
Immune Dysregulation: TH1/TH2 imbalance	5	8
Influenza A	5	8
Liver Cirrhosis	4	8
Osteoporosis	2	8
Hydrogen Peroxide Induced Toxicity	3	7
Obesity	4	7
Breast Cancer: Metastatic	3	6
Cadmium Poisoning	3	6
Chemotherapy and Radiation Toxicity	3	6
Hyperlipidemia	3	6
Memory Disorders	3	6
Myelotoxicity	3	6
Pancreatitis	3	6
Chemotherapy-Induced Toxicity: Doxorubicin	3	5
Cholangiocarcinoma	1	5
Crohn's Disease	1	5
H1N1 Infection	3	5
Kidney Cancer	3	5
Lymphoma	4	5
Multiple Myeloma	4	5
Triglycerides: Elevated	3	5
Acute Myeloid Leukemia	3	4
Allergies	2	4
Anxiety	2	4
Arteriosclerosis	2	4
Arthritis	1	4
Brain Inflammation	3	4
Cancers: Multi-Drug Resistant	3	4
Cerebral Ischemia	2	4
Chemotherapy Induced Myelotoxicity	2	4
Chemotherapy-Induced Toxicity: 5-fluorouracil	2	4
Glioblastoma	1	4
Hair Loss	2	4
High Cholesterol: very low density lipoprotein (VLDL)	2	4
Hypertension	2	4
Hypoxia	3	4
Liver Disease	2	4
Low Immune Function: Natural Killer Cells	2	4
Pseudomonas aeruginosa	4	4
Sepsis	2	4
Skin Cancer	2	4
Cardiovascular Diseases	2	3
Diabetes: Oxidative Stress	2	3
Dyslipidemias	2	3
Hepatitis C	2	3
Herpes Simplex Virus Type 1	3	3
Ischemia	2	3
Laryngeal Cancer	1	3
Organ Transplantation	2	3
Sarcoidosis	1	3
Ultraviolet Radiation Induced Damage	2	3
Acetaminophen (Tylenol) Toxicity	1	2
Aging Skin	1	2
Aging: Brain	1	2
Alcoholic Liver Disease	1	2
Aluminum Toxicity	1	2
Amyloid toxicity	1	2
Amyloid β peptide toxicity	1	2
Anaphylactic Reaction	1	2
Androgen-Induced Diseases	2	2
Animal Cancers	1	2
Arrhythmias: Cardiac	1	2
Asthma: Bronchial	1	2
Atopic Dermatitis	1	2
Autoimmune Diseases	1	2
Brain: Microglial Activation	1	2
Breast Cancer: Drug Resistant	2	2
Breast Cancer: Inflammatory	1	2
Cachexia	1	2
Candida Albicans	2	2
Candidiasis	1	2
Cat Diseases	1	2
Cataract	1	2
Chemotherapy-Induced Toxicity: Bleomycin	1	2
Chemotherapy-Induced Toxicity: Mitomycin-C	1	2
Chemotherapy-Induced Toxicity: Paclitaxel	1	2
Chronic Kidney Disease (CKD)	1	2
Chronic Pain	1	2
Citrobacter Infection	1	2
Colon Cancer: Prevention	1	2
Coronary Artery Disease	1	2
Cysts	1	2
Depression	1	2
Diabetic Nephropathy	1	2
Diabetic Neuropathy	1	2
Duodenal Ulcer	1	2
Dysthymic Disorder	1	2
Enterobacteriaceae Infections	1	2
Epstein-Barr Virus Infections	2	2
Escherichia coli Infections	2	2
Fatty Liver	1	2
Food Allergies	1	2
Gastric Ulcers	1	2
Gastrointestinal Inflammation	1	2
H3N2 Infection	1	2
H5N1 Infection	1	2
HSV-1	1	2
Hepatic Steatosis	1	2
Hepatoma	2	2
Human Flu	1	2
Human Influenza	1	2
Hyperinsulinism	1	2
Hypertension: Portal	1	2
Hyperuricemia	1	2
Hypoglycemia	1	2
Infertility: Male	1	2
Ischemia: Myocardial	1	2
Kidney Fibrosis	1	2
Klebsiella Infections	1	2
Lead Poisoning	1	2
Learning disorders	1	2
Leukemia: Monocytic	2	2
Lipid Metabolism: Abnormalities	1	2
Listeria Infections	1	2
Liver Cancer: Prevention	1	2
Liver Damage	1	2
Liver Fibrosis	1	2
Liver Injury: Ischemia/reperfusion	1	2
Low Immune Function: Splenic Dysfunction	1	2
Low Immune Function: Thymus Dysfunction	1	2
Low Libido	1	2
Lupus Erythematosus: Systemic	1	2
Malaria	1	2
Metabolic Syndrome X	1	2
Mycobacterium tuberculosis	1	2
Neurologic Disorders	2	2
Neutropenia	2	2
Neutropenia: Chemotherapy Induced	2	2
Neutropenia: Cyclic	2	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Organ Transplantation: Skin	1	2
Pancreatitis: Chronic	1	2
Peripheral Nerve Diseases	1	2
Polycystic Kidney Diseases	1	2
Progesterone: Low	1	2
Promyelocytic leukemia	2	2
Pulmonary Cancer	1	2
Pulmonary Fibrosis	1	2
Pulmonary Fibrosis: Bleomycin-Induced	1	2
Radiation Induced Illness: Enteritis	1	2
Sexual Arousal Disorder	1	2
Sexual Dysfunction	1	2
Staphylococcus aureus infection	2	2
Staphylococcus epidermidis	2	2
Stomach Cancer	2	2
Streptococcus Infections	1	2
Streptococcus infections: Group A	1	2
Stress	1	2
Swine Flu Associated Virus	1	2
Systemic Lupus Erythematosus	1	2
Testicular Injury: Cadmium-Induced	1	2
Thrombosis	2	2
Thymic Dysplasia	1	2
Toxoplasma gondii Infection	1	2
Ulcerative Colitis	1	2
Water Retention	1	2
West Nile Fever	1	2
Wound Healing	1	2
Adrenal Gland Diseases	1	1
Adrenal Gland: Enhanced Apoptosis	1	1
Arthritis: Rheumatoid	2	1
Aspergillosis	1	1
Bacillus subtilis infections	1	1
Bacterial Infections and Mycoses	1	1
Brain Hypoxia	1	1
Breast Cancer: Lung Metastasis	1	1
Cancers: Canine	1	1
Cancers: Drug Resistant	1	1
Carcinoma: Small Cell Lung	1	1
Chemotherapy	1	1
Chronic Lymphocytic Leukemia	1	1
Chronic Myeloid Leukemia	1	1
Clotting	1	1
Cryptococcosis	1	1
Cystic Fibrosis	1	1
Demyelinating Diseases	1	1
Dry Skin	1	1
Epilepsy	1	1
Epithelial Neoplasms: Malignant	1	1
Fungal Infection	1	1
Gram-Negative Bacterial Infections	1	1
Gram-Positive Bacterial Infections	1	1
Helicobacter Pylori Infection	1	1
Hepatoma: Multidrug Resistant	1	1
Infant Acute Monocytic Leukemia	1	1
Influenza	1	1
Larynx Neoplasms	1	1
Leukemia: Acute promyelocytic leukemia	1	1
Leukopenia: Chemotherapy Induced	1	1
Malignant Melanoma	1	1
Melanoma: Metastatic	1	1
Micrococcus luteus infections	1	1
Neurological Conditions	1	1
Neutropenia: Severe Congenital	1	1
Osteosarcoma	1	1
Pancreatic Cancer	1	1
Pigmentation Disorders	1	1
Pulmonary Hypertension	1	1
Radiation Disaster Associated Toxicity	1	1
Sarcoma	1	1
Testosterone-Induced	1	1
Tuberculosis	1	1
Vitamin B 12 Deficiency	1	1
Vitamin D Deficiency	1	1

Name	AC	CK
Antioxidants	88	178
Antiproliferative	74	132
Anti-Inflammatory Agents	50	116
Apoptotic	69	113
Immunomodulatory	45	106
Hypoglycemic Agents	26	57
Hepatoprotective	23	50
Neuroprotective Agents	29	47
Antineoplastic Agents	25	45
Cell cycle arrest	28	43
Chemopreventive	15	39
Tumor Necrosis Factor (TNF) Alpha Inhibitor	21	39
Immunostimulatory	11	37
NF-kappaB Inhibitor	19	30
Anti-metastatic	15	28
Antifungal Agents	7	27
Anti-Apoptotic	14	26
Hypolipidemic	13	26
Chemotherapeutic	13	23
Interleukin-1 beta downregulation	12	23
Interleukin-6 Downregulation	12	20
Antiviral Agents	14	19
Malondialdehyde Down-regulation	9	17
Antidepressive Agents	4	16
Anti-Bacterial Agents	13	15
Cardioprotective	9	15
Superoxide Dismutase Up-regulation	8	15
Analgesics	3	14
Cyclooxygenase 2 Inhibitors	10	14
Cytotoxic	11	14
Interleukin-10 upregulation	3	14
Bcl-2 protein down-regulation	6	12
Interferon-gamma (IFN-gamma) inducer	2	12
Anticholesteremic Agents	6	11
Chemoprotective Agents	6	11
Nitric Oxide Inhibitor	4	11
Anxiolytic	1	10
Autophagy Up-regulation	4	10
Gastrointestinal Agents	5	10
Interleukin-4 upregulation	1	10
Matrix metalloproteinase-9 (MMP-9) inhibitor	6	10
Gastroprotective	5	9
Neuritogenic	7	9
Radioprotective	4	9
Alpha-glucosidase inhibitor	6	8
Cyclin D1 Down-Regulation	3	8
Osteoprotective	2	8
Anti-Tumor	4	7
Anticarcinogenic Agents	4	7
Caspase-3 Activation	4	7
Chemosensitizer	5	7
P21 Activation	3	7
Renoprotective	4	7
Tumor Suppressor Protein p53 Upregulation	7	7
Antimutagenic Agents	2	6
Interleukin-12 upregulation	4	6
Nrf2 activation	4	6
Osteogenic	1	6
Pancreato Protective Agents	4	6
Anti-Ulcer Agents	3	5
Antihypertensive Agents	3	5
Caspase-9 Activation	3	5
MicroRNA modulator	4	5
Angiogenesis Inhibitors	2	4
Anti-Angiogenic	3	4
Anti-Anxiety Agents	2	4
Anti-HIV Agents	4	4
Anti-atherogenic	2	4
Antinoceceptive	2	4
Aromatase Inhibitors	3	4
Catalase Up-Regulation	2	4
Enzyme Inhibitors	2	4
Interleukin-4 downregulation	2	4
Neurogenesis	2	4
Prophylactic Agents	2	4
Radiation-Protective Agents	2	4
Antimicrobial	3	3
Heme oxygenase-1 up-regulation	2	3
Matrix metalloproteinase-1 (MMP-1) inhibitor	2	3
Neurominidase Inhibitor	2	3
Tumor Necrosis Factor (TNF) Alpha Enhancer	2	3
5-Lipoxygenase Inhibitor	1	2
5-alpha reductase inhibitor	2	2
Acetylcholinesterase Inhibitor	2	2
Alpha-amylase inhibitor	2	2
Anti-Allergic Agents	1	2
Aphrodisiac	1	2
Bax/Bcl2 ratio: Increase	1	2
Bcl-xL down-regulation	1	2
Brain-derived neurotrophic factor modulator	1	2
Caspase-8 activation	1	2
Cytoprotective	1	2
Diuretics	1	2
Genoprotective	2	2
Glutathione Upregulation	1	2
Heat Shock Protein Down-Regulation	1	2
Hematopoietic	2	2
Interferon Gamma Reducer	1	2
Interleukin-1 beta upregulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-6 upregulation	1	2
Matrix metalloproteinase-2 (MMP-2) inhibitor	2	2
Nitric Oxide Enhancer	2	2
Platelet Aggregation Inhibitors	2	2
Protein tyrosine phosphatase 1B (PTP1B) modulator	1	2
Regenerative	1	2
Secretagogue	1	2
Telomerase Inhibitor	2	2
Topoisomerase I inhibitor	1	2
Topoisomerase II Inhibitor	1	2
Uricosuric Agents	1	2
Vascular Endothelial Growth Factor Inhibitors	1	2
interleukin-13 down-regulation	1	2
Angiotensin-Converting Enzyme Inhibitors	1	1
Anti-Infective Agents	1	1
Anti-Platelet	1	1
Antimycobacterial	1	1
Autophagy Inhibitors	1	1
Cyclooxygenase Inhibitors	1	1
Estrogen Receptor Modulators	1	1
Gene Protective	1	1
HIV Protease Inhibitors	1	1
Interferon Inducers	1	1
Interleukin-10 downregulation	1	1
Interleukin-18 upregulation	1	1
Interleukin-8 downregulation	1	1
Multidrug Resistance Gene Modulators	1	1
Photoprotective	1	1
Platelet aggregation inhibitor: collagen-induced aggregation	1	1
Prostaglandin PGE2 downregulation	1	1
Radiosensitizer	1	1
Reactive Oxygen Species (ROS) attenuation	1	1
Reverse Transcriptase Inhibitors	1	1
Tyrosinase inhibitors	1	1
Wnt/β-catenin pathway down-regulation	1	1
Wnt/β-catenin signaling pathway modulation	1	1

[+]

C. versicolor and G. lucidum related natural products might have potential benefits on the overall survival and quality of life in cancer patients.Dec 31, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Chin Med. 2005;33(4):517-23. PMID: 16173526

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Reishi Mushroom

Diseases : Herpes Zoster, Shingles

[+]

Agaricus blazei extract in combination with metformin and gliclazide improve insulin resistance in type 2 diabetics. Dec 01, 1999

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Pubmed Data : J Surg Oncol. 1999 Dec;72(4):230-9. PMID: 17309383

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian Heart J. 2018 Sep - Oct;70(5):608-614. Epub 2017 Dec 14. PMID: 30392496

[+]

Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity.Dec 31, 2018

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Pubmed Data : Mymensingh Med J. 2007 Jan;16(1):94-9. PMID: 17344789

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Oyster Mushroom

Diseases : Diabetes: Cardiovascular Illness, Diabetes Mellitus: Type 1

Pharmacological Actions : Hypoglycemic Agents

Additional Keywords : Plant Extracts

[+]

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

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Pubmed Data : J Am Coll Nutr. 2015 ;34(6):478-87. Epub 2015 Apr 11. PMID: 25866155

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Pubmed Data : Psychiatry Res. 2015 Jul 15. Epub 2015 Jul 15. PMID: 26208984

Pubmed Data : Int J Med Mushrooms. 2018 ;20(8):705-716. PMID: 30317947

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Beta-glucan, Reishi Mushroom, Yoghurt

Pharmacological Actions : Immunomodulatory

[+]

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Pubmed Data : Inflamm Bowel Dis. 2015 May 19. Epub 2015 May 19. PMID: 25993687

Article Published Date : May 18, 2015

Study Type : Human In Vitro

Additional Links

Substances : Reishi Mushroom

Diseases : Crohn's Disease

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

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Pubmed Data : J Agric Food Chem. 2019 Oct 2 ;67(39):10871-10879. Epub 2019 Sep 23. PMID: 31517482

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Pubmed Data : J Sci Food Agric. 2010 Jan 30 ;90(2):276-80. PMID: 20355042

Article Published Date : Jan 29, 2010

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia

Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Malondialdehyde Down-regulation

Additional Keywords : Plant Extracts

[+]

A fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy.Dec 31, 2016

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Pubmed Data : Front Immunol. 2017 ;8:666. Epub 2017 Jun 12. PMID: 28713364

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Pubmed Data : Int J Med Mushrooms. 2015 ;17(11):1055-60. PMID: 26853960

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents

Additional Keywords : Plant Extracts

[+]

A polysaccharide from Pleurotus nebrodensis might be a promising candidate for preventing hepatic I/R injury.Nov 30, 2017

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Pubmed Data : Int J Biol Macromol. 2017 Dec ;105(Pt 1):447-451. Epub 2017 Jul 11. PMID: 28709897

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Oncol Rep. 2006 Dec;16(6):1181-7. PMID: 17089035

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Lung Cancer, Pulmonary Cancer

[+]

A water-soluble polysaccharide from chaga mushroom had potential as a natural antitumor agent with immunomodulatory activity.Sep 30, 2012

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Pubmed Data : Carbohydr Polym. 2012 Oct 1 ;90(2):870-4. Epub 2012 Jun 17. PMID: 22840014

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Gastric Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Immunomodulatory

Additional Keywords : Plant Extracts

[+]

A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

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Pubmed Data : Pak J Biol Sci. 2014 Sep ;17(9):1079-82. PMID: 26031030

Article Published Date : Aug 31, 2014

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Pubmed Data : Int J Med Mushrooms. 2016 ;18(2):123-32. PMID: 27279534

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Agaricus brasiliensis

Pharmacological Actions : Immunostimulatory, Interleukin-1 beta upregulation, Interleukin-6 upregulation

Additional Keywords : Polysaccharides

[+]

Acetic acid and Reishi mushroom polysaccharide contain lifespan-promoting activity in the nematode. Nov 15, 2009

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Pubmed Data : Bioorg Med Chem.2009 Nov 15;17(22):7831-40. Epub 2009 Sep 6. PMID: 19837596

Article Published Date : Nov 15, 2009

Study Type : Animal Study

Additional Links

Substances : Acetic Acid, Reishi Mushroom

Diseases : Aging

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[+]

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Pubmed Data : J Appl Physiol. 2003 Aug;95(2):491-6. Epub 2003 Apr 11. PMID: 12692142

Article Published Date : Aug 01, 2003

Study Type : Animal Study

Additional Links

Substances : AHCC

Diseases : Klebsiella Infections

Additional Keywords : Space Flight

[+]

AHCC enhances the immune function of mice in a model of spaceflight conditions. Oct 01, 2004

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Pubmed Data : J Appl Physiol. 2004 Oct;97(4):1437-44. Epub 2004 Jun 11. PMID: 15194672

Pubmed Data : J Exp Ther Oncol. 2009;8(1):43-51. PMID: 19827270

Article Published Date : Jan 01, 2009

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Anticancer Agents Med Chem. 2019 Oct 14. Epub 2019 Oct 14. PMID: 31749435

Article Published Date : Oct 13, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative

[+]

Anti-diabetic activity of a polyphenol-rich extract from Phellinus igniarius in KK-Ay mice.Jan 23, 2018

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Pubmed Data : Food Funct. 2018 Jan 24 ;9(1):614-623. PMID: 29271444

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Pubmed Data : J Cell Biochem. 2019 May ;120(5):7482-7488. Epub 2018 Oct 30. PMID: 30378160

Article Published Date : Apr 30, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Poria cocos

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.Dec 31, 2018

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Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869489. PMID: 31462112

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Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs

[+]

Chaga mushroom and its compounds could be used as natural anticancer ingredients.May 31, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res Pract. 2010 Jun ;4(3):177-82. Epub 2010 Jun 29. PMID: 20607061

Article Published Date : May 31, 2010

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Breast Cancer, Carcinoma: Non-Small-Cell Lung, Cervical Cancer, Gastric Cancer

Pharmacological Actions : Antiproliferative

[+]

Chaga mushroom extract significantly reduced the total IgE levels in mice and slightly affected the production of IgG1.Mar 31, 2013

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Pubmed Data : Int Immunopharmacol. 2013 Apr ;15(4):666-70. Epub 2013 Mar 25. PMID: 23535020

Continuous intake of the I. obliquus extract could suppress tumor progression.Apr 30, 2016

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Pubmed Data : Heliyon. 2016 May ;2(5):e00111. Epub 2016 May 12. PMID: 27441282

Article Published Date : Apr 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive

[+]

Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway.Feb 17, 2019

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Pubmed Data : Life Sci. 2019 Feb 18. Epub 2019 Feb 18. PMID: 30790609

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Cordyceps mycelia may ameliorate chemically induced liver cirrhosis. Sep 01, 2009

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Sep;29(9):810-5. PMID: 19960979

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Cordyceps sinensis

Diseases : Liver Cirrhosis

Pharmacological Actions : Hepatoprotective

[+]

Cordyceps mycelia may decrease portal hypertension in rats with chemically induced liver cirrhosis. Nov 01, 2008

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Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2008 Nov;6(11):1136-44. PMID: 18990339

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Pubmed Data : Mol Chem Neuropathol. 1998 Feb;33(2):139-48. PMID: 16014434

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Pubmed Data : Biomed Rep. 2017 Dec ;7(6):567-572. Epub 2017 Oct 11. PMID: 29188061

Article Published Date : Nov 30, 2017

Study Type : Animal Study

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Substances : Coriolus versicolor

Diseases : Cancers: All

Pharmacological Actions : Immunomodulatory

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Pubmed Data : Int J Med Mushrooms. 2020 ;22(1):79-91. PMID: 32464000

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Medicinal Mushrooms

Diseases : Diabetes Mellitus: Type 2, Obesity, Prediabetes

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

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Pharmacological Actions : Anticholesteremic Agents, Hypolipidemic

Additional Keywords : Gene Expression Regulation, Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs

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Ganoderma lucidum polysaccharide (GLP) enhances antitumor immune response by regulating differentiation and inhibition of MDSCs.Jan 25, 2020

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Pubmed Data : J Transl Med. 2015 ;13:100. Epub 2015 Mar 26. PMID: 25889022

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Liver Cancer, Liver Cancer: Prevention

Pharmacological Actions : Antiproliferative , Chemotherapeutic, MicroRNA modulator

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Pubmed Data : Food Chem. 2019 Jan 15 ;271:148-156. Epub 2018 Jul 18. PMID: 30236660

Article Published Date : Jan 14, 2019

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Alcoholic Liver Disease, Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

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Hepatoprotective effects exerted by Poria Cocos polysaccharides against acetaminophen-induced liver injury in mice.Jul 14, 2018

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Pubmed Data : Int J Biol Macromol. 2018 Jul 15 ;114:137-142. Epub 2018 Mar 20. PMID: 29572139

Article Published Date : Jul 14, 2018

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Pubmed Data : Nutrients. 2019 Mar 27 ;11(4). Epub 2019 Mar 27. PMID: 30934760

Article Published Date : Mar 26, 2019

Study Type : Animal Study

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Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Aging: Brain , Memory Disorders

Pharmacological Actions : Neuroprotective Agents

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Hericium erinaceus may provide neuroprotective candidates for treating or preventing neurodegenerative diseases.Oct 31, 2016

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Pubmed Data : Int J Mol Sci. 2016 Nov 1 ;17(11). Epub 2016 Nov 1. PMID: 27809277

Inonotus obliquus polysaccharide ameliorates impaired reproductive function caused by toxoplasma gondii infection.May 14, 2020

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Pubmed Data : Int J Biol Macromol. 2020 May 15 ;151:449-458. Epub 2020 Feb 18. PMID: 32084465

Article Published Date : May 14, 2020

Study Type : Animal Study

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Substances : Chaga Mushroom (Inonotus obliquus)

Diseases : Infertility: Male, Toxoplasma gondii Infection

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Nrf2 activation

Additional Keywords : Polysaccharides

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Inonotus obliquus polysaccharide has strong activity for ameliorating chronic pancreatitis and a beneficial effect on gut microbiota.Nov 30, 2017

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Pubmed Data : AMB Express. 2017 Dec ;7(1):39. Epub 2017 Feb 14. PMID: 28197985

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Pubmed Data : Z Naturforsch C. 2011 Jan-Feb;66(1-2):55-62. PMID: 21476437

Article Published Date : Dec 31, 2010

Study Type : Animal Study

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Substances : Mushrooms: All

Diseases : Alcohol Toxicity , Lipid Peroxidation

Pharmacological Actions : Antioxidants, Gastroprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

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L. edodes extract may have therapeutic potential in the treatment of atopic dermatitis attributable to its immunomodulatory effects.Jul 28, 2016

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View the Evidence: 789 Abstracts with Medicinal Mushrooms Research

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C. versicolor and G. lucidum related natural products might have potential benefits on the overall survival and quality of life in cancer patients.Dec 31, 2018

Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function.Nov 30, 2019

S. crispa extracts are useful for prevention and treatment of human diseases.May 15, 2018

A combination of geranium extract, Ganoderma lucidum, Codonopsis pilosula and Angelicae sinensis, improve the condition of cancer patients receiving chemotherapy/radiotherapy. Jun 01, 2009

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

A mushroom formula containing Reishi (Ganoderma) has therapeutic activity against herpes genitalis and labialis.Nov 01, 2007

A mushroom formula containing Reishi (Ganoderma) reduces pain in patients with Herpes zoster.Jan 01, 2005

Agaricus blazei extract in combination with metformin and gliclazide improve insulin resistance in type 2 diabetics. Dec 01, 1999

Agaricus blazei extract normalizes liver function in patients with chronic hepaititis B. Apr 01, 2008

Agaricus blazei increases natural killer cell activity and quality of life in gynecological cancer patients undergoing chemotherapy. Jul 01, 2004

Agaricus brasiliensis has a wide range of therapeutic properties as demonstrated in mice and human subjects. Jun 01, 2008

AHCC improves prognosis of postoperative liver cancer patients. Jul 01, 2002

AHCC may improve survival and prognosis in patients with advanced liver cancer. Mar 01, 2006

Beta glucan found in reishi mushroom is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients.Oct 01, 2018

Combined therapy of Red sage (S. miltiorrhizae) and Zhu Ling (P. umbellatus) polysaccharide has therapeutic value in the treatment of chronic hepatitis B.Sep 01, 1993

Consumption of Agaricus brasiliensis KA21 for 12 weeks led to many beneficial improvements in health. Dec 31, 2014

Cordyceps and artemisinin prevent the recurrence of lupus nephritis.Mar 01, 2002

Cordyceps may improve renal function and cellular immune function in chronic kidney failure. Jun 01, 1992

Cordyceps may reduce the need for anti-rejection drugs and improve the outcome of renal transplantation. Jun 01, 2009

Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women.Mar 15, 2009

Dongchongxiacao (Cordyceps) can reduce serum markers of airway inflammation of asthmatics.Sep 01, 2005

Fermentation of Pleurotus ostreatus and Ganoderma lucidum mushrooms and their extracts by the gut microbiota of healthy and osteopenic women.Jan 31, 2021

Habitual mushroom intake might help to prevent prostate cancer.Sep 03, 2019

Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity.Dec 31, 2018

Hericium erinaceus intake results in a reduction of depression and anxiety in mice by 4 weeks. Aug 01, 2010

Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections.Jan 31, 2013

Improvement of cognitive functions by oral intake of Hericium erinaceus Dec 31, 2018

Lion's mane improves mild cognitive impairment in human subjects. Mar 01, 2009

Mycoprotein and tofu have satiating properties that persist for several hours after a meal.Jan 01, 2006

Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects.Jan 01, 2007

Regular shiitake mushroom consumption resulted in improved immunity.Dec 31, 2014

Reishi (Ganoderma lucidum) safely improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Sep 01, 2008

Reishi (Ganoderma) has significant therapeutic value in patients with FSGS. Jan 01, 2004

Reishi reduces pain from postherpetic neuralgia. Mar 01, 2006

Results suggest that adherence to a diet rich in vegetables, fruits, and typical Japanese foods is associated with a lower probability of having depressive symptoms.Jul 14, 2015

The mushroom Grifola umbellata is superior to mitomycin C in preventing postoperative recurrence of bladder cancer. Sep 05, 2007

The present intervention demonstrated the antioxidation, anti-aging and hepatoprotective nature of Ganoderma lucidum.Nov 30, 2017

These results found increasingly improved symptom score in the AndoSan group.Dec 31, 2015

This study demonstrates that β-glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood.Dec 31, 2017

White button mushroom appears to both impact PSA levels and modulate the biology of biochemically recurrent prostate cancer.Aug 31, 2015

An extract of G. lucidum spores suppressed cholangiocarcinoma migration in vitro through inhibition of TGF-β1-induced EMT.May 14, 2016

Chaga mushroom extract can inhibit the proliferation of tumor cells.Dec 31, 2013

Combined application of Grifola frondosa and vitamin C induced cell apoptosis and autophagy in vitro.Sep 10, 2017

These preliminary results demonstrated anti-genotoxic properties of Agaricus blazei.Dec 31, 2016

Triterpene ganoderic acid inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation.May 18, 2015

verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells. Aug 31, 2015

A case report of Korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer. Dec 31, 2014

A patient with annular cutaneous sarcoidosis showed almost complete regression of lesions.Feb 29, 2016

16α-hydroxytrametenolic acid from Poria cocos improves intestinal barrier function.Oct 01, 2019

A combined mixture of medicinal mushrooms and P. ginseng root extracts could be an adjuvant treatment in human colorectal cancer.Aug 31, 2017

A derived protein fraction from oyster mushroom exhibits anti-tumor properties in Dalton's lymphoma bearing mice. Jan 01, 2011

A fraction from I. obliquus showed significant antihyperglycaemic and antilipidperoxidative effects in alloxan-induced diabetic mice.Jan 29, 2010

A fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy.Dec 31, 2016

A hybridized strain of Cordyceps (Paecilomyces hepiali) may prevent autoimmune diseases like type 1 diabetes by maintaining the dendritic cells in a tolerogenic state. Oct 20, 2005

A mixture of asian herbs increases progesterone secretion in female rats.Jan 01, 1991

A polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.Dec 31, 2014

A polysaccharide from Pleurotus nebrodensis might be a promising candidate for preventing hepatic I/R injury.Nov 30, 2017

A polysaccharide from the mycelia of G. lucidum might be used as functional agent to regulate the intestinal barrier functions.Sep 28, 2016

A polysaccharide, extract from Maitake, induces Th-1 dominant responses in cancer-bearing mice. Dec 01, 2002

A reishi extract ameliorates the colon precancerous lesions induced by AOM and the small-intestinal injury caused by 5-FU.May 31, 2013

A selenium enriched polysaccharide from Grifola frondosa significantly inhibited the growth of Heps tumor in vivo.Dec 31, 2015

A water extract of broken spores of G. lucidum possesses chemopreventive potential in colorectal cancer.Apr 30, 2017

A water extract of Chaga mushroom is a very potent immune modulator that recovers the bone marrow system damaged by chemotherapy.Aug 31, 2005

A water extract of maitake mushroom reduces circulating glucose/insulin concentrations in insulin-resistant mice. Jan 01, 2002

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

A water-soluble extract of Reishi mushroom inhibits the development of lung tumors in rats. Dec 01, 2006

A water-soluble polysaccharide from chaga mushroom had potential as a natural antitumor agent with immunomodulatory activity.Sep 30, 2012

A white button mushroom extract acted as a potent dietary antioxidant and protects against Al-mediated neurotoxicity, by abrogating neuronal oxidative stress.Aug 31, 2014

A. blazei extract offers a promising and new therapeutic lead for treatment of Parkinson's disease.Jun 18, 2017

A. brasiliensis and G. lucidum have pronounced antioxidant properties. Dec 31, 2014

Medicinal Mushrooms

View the Evidence:
789 Abstracts with Medicinal Mushrooms Research