Nigella sativa (aka Black Seed)

Name	AC	CK
Obesity	5	62
Oxidative Stress	25	58
Diabetes Mellitus: Type 2	8	50
Hypertension	7	39
Asthma	8	37
Helicobacter Pylori Infection	4	31
Hyperglycemia	4	25
Lipid Peroxidation	13	25
Insulin Resistance	4	24
Rheumatoid Arthritis	4	23
High Cholesterol	2	22
Inflammation	9	22
Triglycerides: Elevated	2	21
Allergic Rhinitis	2	20
Cardiovascular Disease: Prevention	1	20
Chemotherapy and Radiation Toxicity	6	20
Dyspepsia	2	20
Hashimoto's thyroiditis	2	20
Hyperlipidemia	6	19
Chemically-Induced Liver Damage	8	16
Cognitive Decline/Dysfunction	4	16
Memory Disorders	5	16
Chemotherapy-Induced Toxicity: Cisplatin	7	14
Diabetic Complications	8	14
Diabetic Nephropathy	3	14
Dyslipidemias	4	14
Wound Healing	3	14
Drug-Induced Toxicity: Methotrexate	3	13
Kidney Stones	3	13
Liver Cancer	6	13
Chemical Weapon Agent Injury	2	12
Cholesterol: LDL/HDL ratio	2	12
Diabetes: Oxidative Stress	6	12
HDL: Low	2	12
Metabolic Diseases	2	12
Rhinosinusitis	2	12
Hepatitis C	2	11
A1C	1	10
Acute lymphoblastic leukemia (ALL)	1	10
Breast Cancer	5	10
C-Reactive Protein	1	10
Chemotherapy-Induced Toxicity: Gentamicin	5	10
Cholesterol: High	1	10
Diabetes: Glycation/A1C	1	10
Diabetic Ulcer	1	10
Eosinophilia	1	10
Epilepsy: Childhood	1	10
Infertility: Male	1	10
Mastalgia	1	10
Metabolic Syndrome X	1	10
Nonalcoholic fatty liver disease (NAFLD)	1	10
Opiate Addiction/Withdrawal	1	10
Osteoarthritis	1	10
Osteoarthritis: Knee	1	10
Pharyngitis	1	10
Sickle Cell Anemia	1	10
Sperm Quality: Low	1	10
Tonsillitis	1	10
Vitiligo	1	10
Acetaminophen (Tylenol) Toxicity	4	8
Cancers: All	8	8
Ischemia	5	8
Kidney Damage	5	8
Neurodegenerative Diseases	6	8
Colon Cancer	4	7
Alcohol Toxicity	3	6
Cervical Cancer	2	6
Endothelial Dysfunction	3	6
Hyperinsulinism	3	6
Lead Poisoning	3	6
Lipopolysaccharide-Induced Toxicity	3	6
Osteoporosis	3	6
Pain	4	6
Staphylococcus aureus: Methicillin-resistant (MRSA)	2	6
Fibrosis	3	5
Hydrogen Peroxide Induced Toxicity	1	5
Multiple Sclerosis	3	5
Alzheimer's Disease	4	4
Brain: Oxidative Stress	2	4
Cadmium Poisoning	2	4
Chemotherapy-Induced Toxicity: Cyclophosphamide	2	4
Chronic Pain	2	4
Diabetes Mellitus: Type 1	2	4
Epilepsy	3	4
Gastritis	2	4
Hypothyroidism	2	4
Kidney Cancer	2	4
Liver Damage	3	4
Menopausal Syndrome	2	4
Morphine Tolerance/Dependence	2	4
Pulmonary Fibrosis: Bleomycin-Induced	2	4
Schistosomiasis	2	4
Seizures	2	4
Staphylococcus aureus infection	4	4
Chemotherapy-Induced Toxicity: Doxorubicin	2	3
Escherichia coli Infections	3	3
Fungal Infection	2	3
Gastric Ulcer	2	3
HIV Infections	1	3
Hypoglycemia	2	3
Salmonella Infections	3	3
Abdominal Adhesions	1	2
Aflatoxicosis	1	2
Aging	1	2
Allergies	2	2
Anxiety	1	2
Aspirin-Induced Toxicity	1	2
Asthma: Bronchial	2	2
Bacillus Cereus infection	2	2
Bacillus subtilis infections	2	2
Breast Cancer: Chemically-Induced	1	2
Cancers: Radiation-Induced	1	2
Candidiasis	1	2
Cataract: Radiation-Induced	1	2
Central Nervous System Diseases	2	2
Cerebral Hypoperfusion	1	2
Cerebral Ischemia	1	2
Chemotherapy-Induced Toxicity: Kidney	1	2
Chemotherapy-Induced Toxicity: Tamoxifen	1	2
Cholestasis	1	2
Corticosteroid-Induced Toxicity	1	2
Cytomegalovirus Infections	1	2
DNA damage	1	2
Dementia	1	2
Diabetic Microangiopathy	1	2
Diabetic Neuropathies	1	2
Diabetic Neuropathy	1	2
Diarrhea	1	2
Drug-Induced Toxicity	1	2
Drug-Induced Toxicity: Cyclosporine	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Encephalomyelitis	1	2
Fatigue: Excercise-Induced	1	2
Food Allergies	1	2
Formaldehyde Toxicity	1	2
Fructose-Induced Toxicity	1	2
Gram-Negative Bacterial Infections	2	2
Gram-Positive Bacterial Infections	2	2
HIV Drug-Induced Toxicity	1	2
Hearing Loss: Noise-Induced	1	2
High Fat Diet	1	2
High Fructose Diet	1	2
High Homocysteine	1	2
Hypercholesterolemia	1	2
Inflammatory Bowel Diseases	1	2
Intestinal Ischemia	1	2
Keratitis	1	2
Kidney Cancer: Prevention	1	2
Kidney Damage: Chemically-Induced	1	2
Kidney Damage: Drug-Induced	1	2
Kidney Fibrosis	1	2
Learning disorders	1	2
Liver Damage: Aflatoxin-Induced	1	2
Lung Cancer	1	2
Lung Damage	1	2
Mucosal Damage: Radiation Induced	1	2
Myocardial Fibrosis	1	2
Osteopenia	1	2
Ovarian Failure	1	2
Pancreatic Cancer	2	2
Parkinson's Disease	2	2
Pesticide Toxicity	1	2
Postmenopausal Disorders	1	2
Prenatal Chemical Exposures	1	2
Radiation Induced Illness: Mucositis	1	2
Sodium nitrate toxicity	1	2
Spinal Cord Injuries	1	2
Stomach Cancer	1	2
Toxoplasma gondii Infection	1	2
Toxoplasmosis	1	2
Traumatic Brain Injury	2	2
Ulcerative Colitis	1	2
Urolithiasis	1	2
Autoimmune Diseases	1	1
Bacterial Infections	1	1
Bacterial Infections: Resistance/Biofilm Formation	1	1
Blastocystis hominis infections	1	1
Brain Ischemia	1	1
Breast Milk: Inadequate/Poor Quality	1	1
Cancer Metastasis	1	1
Cardiovascular Diseases	1	1
Chemotherapy-Induced Kidney Damage	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clostridium Infections	1	1
Cough	1	1
Depression	1	1
Diabetes	1	1
Histamine: Elevated	1	1
Hodgkin Lymphoma	1	1
Hypersensitivity: Respiratory	1	1
Infection: Antibiotic Resistant	1	1
Kidney Diseases	1	1
Klebsiella Infections	1	1
Leishmaniasis	1	1
Liver Disease	1	1
Liver Diseases	1	1
Lung Diseases	1	1
Lymphoma	1	1
MRSA	1	1
Nephrolithiasis	1	1
Neurotoxicity	1	1
Pseudomonas aeruginosa	1	1
Pulmonary Emphysema	1	1
Respiratory Diseases	1	1
Rheumatism	1	1
Ulcers	1	1

Name	AC	CK
Antioxidants	67	142
Hypoglycemic Agents	18	99
Anti-Inflammatory Agents	31	80
Hypolipidemic	17	80
Antihypertensive Agents	9	50
Chemoprotective Agents	19	45
Hepatoprotective	18	42
Neuroprotective Agents	23	42
Anticholesteremic Agents	5	35
Renoprotective	18	33
Anti-Bacterial Agents	9	31
Malondialdehyde Down-regulation	15	30
Analgesics	8	29
Immunomodulatory	7	27
Superoxide Dismutase Up-regulation	10	27
Antiproliferative	11	22
Bronchodilator Agents	3	22
Apoptotic	13	21
Anti-Ulcer Agents	6	19
Insulin Sensitizers	4	16
Tumor Necrosis Factor (TNF) Alpha Inhibitor	4	16
Anticarcinogenic Agents	8	14
Gastroprotective	7	14
Radioprotective	7	14
Anti-Apoptotic	7	12
Chemotherapeutic	3	12
Vascular Endothelial Growth Factor Inhibitors	2	12
Chemopreventive	6	11
NF-kappaB Inhibitor	2	11
Fertility Agents: Male	1	10
Hypotensive	1	10
anti-inflammatory	1	10
Anti-Fibrotic	4	8
Pancreato Protective Agents	4	8
Antiviral Agents	4	7
Nitric Oxide Inhibitor	4	7
Tumor Suppressor Protein p53 Upregulation	3	7
Anticonvulsants	4	6
Antifungal Agents	5	6
Antimicrobial	6	6
Antineoplastic Agents	2	6
Anti-metastatic	4	5
Caspase-3 Activation	1	5
Caspase-8 activation	1	5
Caspase-9 Activation	1	5
Angiogenesis Inhibitors	3	4
Antiparasitic Agents	3	4
Cytoprotective	2	4
Antinoceceptive	2	3
Interleukin-6 Downregulation	2	3
Acetylcholinesterase Inhibitor	1	2
Analgesics: Non-Narcotic	1	2
Anti-Anxiety Agents	1	2
Anticholinergic	1	2
Cyclooxygenase 2 Inhibitors	2	2
Genoprotective	1	2
Gluconeogenesis Inhibitor	1	2
Heme oxygenase-1 up-regulation	1	2
Histamine Antagonists	1	2
Histamine down-regulation	2	2
Insulin-releasing	1	2
Interferon Inducers	1	2
Interleukin-1 beta downregulation	1	2
MicroRNA modulator	1	2
Osteoprotective	1	2
Prophylactic Agents	1	2
Remyelination	1	2
Vascular Endothelial Growth Factor A Inhibitor	1	2
Vasodilator Agents	1	2
Anti-Allergic Agents	1	1
Anti-Asthmatic Agents	1	1
Antidepressive Agents	1	1
Antispasmodic	1	1
Antitussive Agents	1	1
Bcl-2 protein down-regulation	1	1
Cardioprotective	1	1
Cyclooxygenase 1 Inhibitor	1	1
Galactogogue	1	1
Gastrointestinal Agents	1	1
Leishmanicidal	1	1
Leukotriene Antagonists	1	1
Leukotriene D4 antagonist	1	1
Postaglandin PGE2 downregulation	1	1
STAT3 Inhibitor	1	1

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran Red Crescent Med J. 2016 Nov ;18(11):e23771. Epub 2016 Jun 21. PMID: 28191328

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Pubmed Data : J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18772804. PMID: 29717629

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Substances : Aloe Vera, Nigella sativa (aka Black Seed)

Diseases : Diabetic Ulcer, Wound Healing

[+]

N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.Dec 31, 2016

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Pubmed Data : Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. PMID: 28151459

Article Published Date : Dec 31, 2016

Pubmed Data : J Ethnopharmacol. 2013 Jul 30 ;148(3):780-6. Epub 2013 May 21. PMID: 23707331

Article Published Date : Jul 29, 2013

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Cognitive Decline/Dysfunction, Memory Disorders

[+]

Nigella sativa oil concurrent with a low-calorie diet decreased weight and increased SOD levels in obese women.Jul 13, 2015

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Pubmed Data : Phytother Res. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26179113

Article Published Date : Jul 13, 2015

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Obesity, Oxidative Stress

Therapeutic Actions : Dietary Modification: Low Calorie Diet

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

[+]

Nigella sativa oil supplementation combined with a calorie-restricted diet may modulate systemic inflammatory biomarkers in obese women.Aug 31, 2016

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Pubmed Data : J Clin Lipidol. 2016 Sep-Oct;10(5):1203-11. Epub 2015 Dec 7. PMID: 27678438

Article Published Date : Aug 31, 2016

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Pubmed Data : Phytother Res. 2017 Jan 17. Epub 2017 Jan 17. PMID: 28093815

Article Published Date : Jan 16, 2017

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Asthma, Eosinophilia

Pharmacological Actions : anti-inflammatory

Additional Keywords : anti-inflammatory, Asthma, Black Seed, Eosinophilia, Nigella sativa oil (NSO)

[+]

Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.Nov 15, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Nov 16 ;16(1):471. Epub 2016 Nov 16. PMID: 27852303

Article Published Date : Nov 15, 2016

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Hashimoto's thyroiditis

Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

[+]

The fixed oil extracted from Nigella sativa seeds has an in vitro antisickling activity.Feb 28, 2010

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Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.Dec 31, 2015

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Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):104-16. PMID: 27247927

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Lipopolysaccharide-Induced Toxicity

Additional Keywords : Plant Extracts

[+]

A hydroalcoholic extract of the Nigella sativa decreased oxidative stress in hippocampus of the STZ-induced diabetic rats.Jun 30, 2015

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Pubmed Data : Avicenna J Phytomed. 2015 Jul-Aug;5(4):333-40. PMID: 26445713

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Brain: Oxidative Stress, Diabetic Complications

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

A liposomal preparation of black seed oil demonstrated significant analgesic activity in mice.Feb 28, 2017

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Pubmed Data : Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID: 16309544

Pubmed Data : Neurosci Lett. 2010 Oct 4;482(3):183-7. Epub 2010 Jun 11. PMID: 16092657

Article Published Date : Oct 04, 2010

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Cholesterol: LDL/HDL ratio, HDL: Low, High Cholesterol

[+]

Black cumin may have antidiabetic effects by increasing insulin sensitivity. Jan 01, 2011

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Pubmed Data : Evid Based Complement Alternat Med. 2011;2011:538671. Epub 2011 Apr 14. PMID: 21584245

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance

Pharmacological Actions : Insulin Sensitizers

[+]

Black cumin oil decreased the proinflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis.Feb 28, 2011

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Pubmed Data : Dig Dis Sci. 2011 Mar ;56(3):721-30. Epub 2010 Jul 24. PMID: 20658190

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Pubmed Data : Nutr Cancer. 2003;45(2):195-202. PMID: 12881014

Article Published Date : Jan 01, 2003

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative

[+]

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Pubmed Data : J Ethnopharmacol. 2003 Feb ;84(2-3):251-8. PMID: 12648823

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):86-94. PMID: 27247925

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Pubmed Data : Exp Toxicol Pathol. 2010 Mar ;62(2):183-90. Epub 2009 Apr 23. PMID: 19398313

Article Published Date : Feb 28, 2010

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Chemotherapy-Induced Toxicity: Gentamicin

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Phytotherapy

[+]

Nigella sativa and nettle decrease lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in CCl4-treated rats.May 31, 2003

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Pubmed Data : J Vet Med A Physiol Pathol Clin Med. 2003 Jun ;50(5):264-8. PMID: 14567515

Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat.Sep 30, 2004

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Pubmed Data : J Ethnopharmacol. 2004 Oct ;94(2-3):251-9. PMID: 15325727

Article Published Date : Sep 30, 2004

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Hyperlipidemia, Insulin Resistance

Pharmacological Actions : Hypolipidemic, Insulin Sensitizers

Additional Keywords : Plant Extracts

Problem Substances : Insulin

[+]

Nigella sativa extract affects conditioned place preference induced by morphine in rats, indicating it may have therapeutic value in treating morphine dependence and/or tolerance.Sep 30, 2012

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Pubmed Data : 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Morphine Tolerance/Dependence

[+]

Nigella sativa extract has an anti-fatigue activity against exhaustive swimming.Mar 31, 2017

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Pubmed Data : Biomed Rep. 2017 Apr ;6(4):468-474. Epub 2017 Feb 24. PMID: 28413647

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Fatigue: Excercise-Induced

Therapeutic Actions : Exercise: Swimming

Pharmacological Actions : Antioxidants

[+]

Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity. Mar 31, 2014

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Pubmed Data : Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID: 25911839

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Pubmed Data : PLoS One. 2017 ;12(5):e0172429. Epub 2017 May 15. PMID: 28505155

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Antioxidants, Neuroprotective Agents

[+]

Nigella sativa oil imparted a protective action against ethanol induced ulcer in rats.Aug 31, 2000

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Pubmed Data : J Ethnopharmacol. 2000 Sep ;72(1-2):299-304. PMID: 10967486

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Pubmed Data : J Ethnopharmacol. 2002 Jan ;79(1):1-11. PMID: 11744288

Article Published Date : Dec 31, 2001

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Schistosomiasis

Pharmacological Actions : Antioxidants

Additional Keywords : Plant Oils

[+]

Nigella sativa oil might be beneficial for controlling hypertension.Oct 31, 2015

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Pubmed Data : Clinics (Sao Paulo). 2015 Nov ;70(11):751-7. PMID: 26602523

Article Published Date : Oct 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Hypertension

Pharmacological Actions : Antihypertensive Agents, Heme oxygenase-1 up-regulation

Additional Keywords : Natural Substances Versus Drugs

[+]

Nigella sativa oil protects kidney tissue against oxygen free radicals.Dec 31, 2007

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Pubmed Data : Am J Nephrol. 2008 ;28(3):517-22. Epub 2008 Jan 25. PMID: 18223305

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Pubmed Data : J Craniofac Surg. 2016 Aug 10. Epub 2016 Aug 10. PMID: 27513784

Article Published Date : Aug 09, 2016

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Osteoporosis

Additional Keywords : Ovariectomy-Induced Changes

[+]

Nigella sativa seed extract has protective effects against acetaminophen induced hepatotoxicity and metabolic disturbances in rats.Feb 29, 2016

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Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID: 26972391

Article Published Date : Feb 29, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

[+]

Nigella sativa seed oil has a protective effect against cisplatin induced acute kidney injury.Dec 04, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Dec 5 ;85:7-15. Epub 2016 Dec 5. PMID: 27930989

Article Published Date : Dec 04, 2016

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

Nigella sativa seeds possess potent anti-inflammatory effects that were not as strong as diclofenac sodium but was more prolonged in effect.Jun 30, 2015

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Pubmed Data : J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6. PMID: 26720998

Article Published Date : Jun 30, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Diclofenac

[+]

Nigella sativa treatment might be beneficial in lung injury and have potential clinical use.Dec 31, 2008

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Pubmed Data : Acta Histochem. 2009 ;111(5):393-403. Epub 2009 May 9. PMID: 19428057

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Pubmed Data : BMC Complement Altern Med. 2016 Nov 4 ;16(1):438. Epub 2016 Nov 4. PMID: 27814700

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Pubmed Data : Wien Klin Wochenschr. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25860848

Article Published Date : Apr 09, 2015

Study Type : Animal Study

Additional Links

Substances : Bee Propolis, Caffeic acid phenethyl ester, Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Cataract: Radiation-Induced

Pharmacological Actions : Radioprotective

Additional Keywords : Plant Extracts

Anti Therapeutic Actions : Low Dose Ionizing Radiation

[+]

Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa.Aug 31, 2010

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Pubmed Data : Int J Radiat Biol. 2010 Sep ;86(9):719-31. PMID: 20670109

Article Published Date : Aug 31, 2010

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Chemotherapy and Radiation Toxicity, Lipid Peroxidation

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Radioprotective

Additional Keywords : Plant Extracts

[+]

Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats.Dec 31, 2012

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Pubmed Data :

PMID: 23947821

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Pubmed Data : Acta Cir Bras. 2018 Jun ;33(6):518-523. PMID: 30020313

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Honey, Nigella sativa (aka Black Seed)

Diseases : Wound Healing

Additional Keywords : Natural Substance Synergy

[+]

The combination of nigella sativa oil and pyrimethamine had a synergistic effect in the treatment of toxoplasmosis.Oct 06, 2015

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Pubmed Data : Parasitol Res. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26446086

Article Published Date : Oct 06, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Toxoplasma gondii Infection, Toxoplasmosis

Therapeutic Actions : Integrative Medicine

Pharmacological Actions : Antioxidants

Additional Keywords : Natural Substance/Drug Synergy

[+]

The effect of chronic supplementation of Nigella sativa on splenocytes response in rats following treadmill exercise.May 28, 2019

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Pubmed Data : Drug Chem Toxicol. 2019 May 29:1-6. Epub 2019 May 29. PMID: 31137984

Article Published Date : May 28, 2019

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Fatigue: Excercise-Induced

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory

[+]

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease.Jul 09, 2019

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Pubmed Data : Phytother Res. 2019 Jul 10. Epub 2019 Jul 10. PMID: 31293021

Article Published Date : Jul 09, 2019

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Cardiovascular Diseases, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

These finding indicated the probable beneficial role for N. sativa in the treatment of postmenopausal symptoms.Dec 31, 2015

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Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):95-103. PMID: 27247926

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Nigella sativa (aka Black Seed)

Diseases : Menopausal Syndrome, Postmenopausal Disorders

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These findings validate the use of Black seed in gastropathies induced by necrotizing agents. Jun 30, 2008

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Pubmed Data : Eur J Pharmacol. 2000 Jul 14 ;400(1):89-97. PMID: 10913589

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Pubmed Data : J Ethnopharmacol. 2001 Jun ;76(1):45-8. PMID: 11378280

Article Published Date : May 31, 2001

Study Type : Animal Study

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Substances : Nigella sativa (aka Black Seed)

Diseases : Inflammation

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

Additional Keywords : Folk Medicine

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Thymoquinone and black cumin seed (Nigella sativa) oil exert a protective effect against breast carcinogens.Mar 15, 2015

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Additional Keywords : Dose Response

[+]

N. sativa is rich source of different biologically active compounds and is found effective in controlling number of cardiovascular diseases and various cancers both in vivo and in vitro studies. Nov 30, 2014

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Pubmed Data : Iran J Basic Med Sci. 2014 Dec ;17(12):967-79. PMID: 25859300

Article Published Date : Nov 30, 2014

Study Type : Review

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Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Cancers: All, Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

Additional Keywords : Plant Extracts

[+]

A literature review of the medicinal benefits of Nigella sativa in bronchial asthma.Nov 30, 2017

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Bee honey and Nigella sativa are effective in reducing the viability of HepG2 cells.Nov 30, 2012

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Pubmed Data : Integr Cancer Ther. 2012 Dec ;11(4):354-63. Epub 2010 Dec 8. PMID: 21147814

Article Published Date : Nov 30, 2012

Study Type : In Vitro Study

Additional Links

Substances : Honey, Nigella sativa (aka Black Seed)

Diseases : Liver Cancer

Pharmacological Actions : Antineoplastic Agents, Antioxidants, Apoptotic

Additional Keywords : Plant Extracts

[+]

Black cumin contains a nigellone and thymoquinone which block leukotriene D4 which is associated with respiratory disease. Feb 01, 2008

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Pubmed Data : Planta Med. 2008 Feb;74(2):105-8. Epub 2008 Jan 24. PMID: 18219598

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Pubmed Data : Front Pharmacol. 2018 ;9:1075. Epub 2018 Oct 2. PMID: 30333747

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Pubmed Data : J Med Food. 2009 Apr ;12(2):408-15. PMID: 19459745

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Pubmed Data : Int Immunopharmacol. 2015 Sep ;28(1):295-304. Epub 2015 Jun 26. PMID: 26117430

Article Published Date : Aug 31, 2015

Study Type : Review

Additional Links

Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Allergies, Autoimmune Diseases, Cancers: All, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

[+]

N. Sativa alone or in combination with oxidative stress were found to be effective in vitro in inactivating MCF-7 breast cancer cellsDec 31, 2002

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Pubmed Data : Biomed Sci Instrum. 2003 ;39:359-64. PMID: 12724920

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Pubmed Data : J Ethnopharmacol. 2009 Jan 30 ;121(3):419-24. Epub 2008 Nov 17. PMID: 19061948

Nigella sativa: reduces the risk of various maladies.Jul 31, 2010

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Pubmed Data : Crit Rev Food Sci Nutr. 2010 Aug ;50(7):654-65. PMID: 20694927

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Pubmed Data : Curr Pharm Biotechnol. 2018 ;19(1):43-67. PMID: 29701149

Pubmed Data : Ultrason Sonochem. 2016 Jul ;31:449-55. Epub 2016 Jan 29. PMID: 26964971

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Pubmed Data : Pak J Pharm Sci. 2016 Jan ;29(1):231-7. PMID: 26826815

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : HPB (Oxford). 2009 Aug ;11(5):373-81. PMID: 19768141

Article Published Date : Jul 31, 2009

Study Type : In Vitro Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Pancreatic Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, NF-kappaB Inhibitor

[+]

Thymoquinone is a good candidate that can be exploited as a novel neutraceutical for combinatorial therapy to treat breast cancer.Jan 23, 2019

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Pubmed Data : Anticancer Agents Med Chem. 2019 Jan 24. Epub 2019 Jan 24. PMID: 30678630

Article Published Date : Jan 23, 2019

Study Type : In Vitro Study

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View the Evidence: 288 Abstracts with Nigella sativa (aka Black Seed) Research

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A systematic review and meta-analysis of the effect of Nigella sativa supplementation on obesity indices.May 31, 2018

Current findings suggest N. sativa supplementation a suitable choice in managing the complications of T2D.Nov 30, 2017

N. sativa consumption has a significant lowering effect on glycemic status.Mar 13, 2019

Nigella Sativa has a significant impact on plasma lipid concentrations, leading to lower total cholesterol.Feb 09, 2016

Supplementation with N. sativa exerts a moderate effect on reduction in body weight, body mass index and waist circumference.Mar 16, 2018

This meta-analysis suggests that short-term treatment with N. sativa powder can significantly reduce SBP and DBP levels.Aug 09, 2016

This meta-analysis suggests thatN. sativa seed and seed oil supplementation can significantly reduce serum CRP level.Jul 31, 2019

A randomized controlled trial of a herbal compound for improving metabolic parameters in diabetic patients with uncontrolled dyslipidemia.Feb 05, 2019

Black cumin (Nigella sativa) and Phyllanthus niruri provide symptomatic relief in the treatment of acute tonsillo-pharyngitis patients.Jun 01, 2008

Black cumin (Nigella sativa) has a prophylactic effect on chemical war victims. Nov 01, 2008

Black cumin (Nigella sativa) is effective in long-term treatment of opioid dependence. Apr 01, 2008

Black cumin alleviates symptoms of allergic rhinitis. Oct 12, 2010

Black cumin possesses clinical useful anti-H. pylori activity compared to triple therapy.Jul 01, 2010

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Black cumin seeds have significant anti-diabetic effects in type 2 diabetics. Oct 01, 2010

Black cumin seeds improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto's thyroiditis.Mar 26, 2018

Consumption of Nigella sativa can reduce the inflammatory biomarkers in patients with NAFLD.May 31, 2019

Daily intake of N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects.May 14, 2014

Dosin eradicated H. pylori in about 57% of infected patients.Oct 31, 2016

Effectiveness of topical Nigella sativa for vitiligo treatment.Apr 24, 2019

Honey and celery seeds could be beneficial in bronchial asthma.May 31, 2019

It is recommended that clinicians and wound care nurses use aloe vera gel instead of Nigella sativa oil gel for the topical treatment of diabetic ulcers.Dec 31, 2017

N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.Dec 31, 2016

N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients.Apr 27, 2013

N. sativa is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.Mar 13, 2019

N. sativa oil was found to be effective as an add-on therapy in patients of insulin resistance syndrome.Dec 31, 2007

N. sativa seed oil has clinical effectiveness comparable to topical diclofenac in the treatment of cyclic mastalgia.Nov 18, 2015

N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy.Dec 31, 2009

N. sativa seeds is beneficial in relieving the symptoms of knee osteoarthritis.Apr 04, 2017

Nigella sativa (black cumin) has potent antiasthmatic properties. Feb 08, 2010

Nigella sativa could improve inflammation and reduce oxidative stress in patients with rheumatoid arthritis.Dec 31, 2015

Nigella sativa enhances memory, attention and cognition in healthy human volunteers.Jul 29, 2013

Nigella sativa oil concurrent with a low-calorie diet decreased weight and increased SOD levels in obese women.Jul 13, 2015

Nigella sativa oil supplementation combined with a calorie-restricted diet may modulate systemic inflammatory biomarkers in obese women.Aug 31, 2016

Nigella sativa oil supplementation had a protective effect in diabetic nephropathy.Dec 31, 2016

Nigella sativa seeds powder may be of interest in lowering lipid concentrations in hyperlipidemic subjects.Mar 14, 2019

Nigella sativa seeds showed a decrease in incidence of febrile neutropenia in children with brain tumors undergoing chemotherapy.Mar 26, 2017

Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial.Jan 16, 2017

Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.Nov 15, 2016

Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal WomenDec 31, 2013

Supplementation of honey and N. sativa can cause significant symptomatic improvement of patients with functional dyspepsia whom received the standard anti-secretory therapy.Sep 15, 2015

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

The daily use of black cumin seeds for 2 months may have a blood pressure-lowering effect in patients with mild hypertension. Apr 01, 2006

The fixed oil extracted from Nigella sativa seeds has an in vitro antisickling activity.Feb 28, 2010

The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients.Dec 31, 2017

The water extract of black cumin seed has significant anti-epileptic activity in children.Dec 01, 2007

This study gives strength to the potential relevance of Nigella sativa in clinical management of rheumatoid arthritis.Apr 30, 2016

Topical application of Nigella sativa oil was effective in reducing pain in patients with knee osteoarthritis.Oct 31, 2016

A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-foldJan 31, 2013

N. sativa oil could be used against multi-drug resistant S. aureus in the treatment of diabetic wounds.Oct 31, 2015

Nigella sativa has successfully produced inhibition of growth of MCF cell lines with an equivalent potency as that of the standard cisplatin.Mar 31, 2015

Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.Dec 31, 2015

Nigella Sativa Concoction Induced Sustained Seroreversion in HIV Patient.Dec 31, 2012

"Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors."Dec 31, 2011

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

A hydro-alcoholic extract of nigella sativa reduced the LPS-induced sickness behaviors in rats.Dec 31, 2015

A hydroalcoholic extract of the Nigella sativa decreased oxidative stress in hippocampus of the STZ-induced diabetic rats.Jun 30, 2015

A liposomal preparation of black seed oil demonstrated significant analgesic activity in mice.Feb 28, 2017

A plant mixture comprising Nigella sativa, Myrrh, Gum Olibanum (Frankincense), Gum Asafoetida and Aloe lowers blood sugar by inhibiting hepatis gluconeogenesis. Dec 01, 1991

A thymoquinone-rich fraction extracted from Nigella sativa effectively improved the plasma and liver antioxidant capacity.Feb 28, 2010

Active components in Nigella sativa and Olive oil may prove useful in treating impaired cognition.Nov 20, 2016

Administration of either nigella sativa oil counteracts dexamethasone induced-gastric lesions.Feb 09, 2017

Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.Nov 30, 2005

Administration of Nigella sativa can be used to prevent formaldehyde induced apoptosis and epithelial damage.Apr 30, 2017

Administration of Nigella sativa seed oil exerts a protective effect against urolithiasis.Dec 31, 2015

Black cumin exhibit significant antifungal activity against candidasis in mice. Feb 01, 2003

Black cumin extract reduces the damage caused by cadmium poisoning in rats.May 01, 2006

Black Cumin improves blood lipid profiles.Oct 04, 2010

Black cumin may have antidiabetic effects by increasing insulin sensitivity. Jan 01, 2011

Black cumin oil decreased the proinflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis.Feb 28, 2011

Black cumin protects against chemical weapon agent induced lung injury. May 01, 2008

Nigella sativa (aka Black Seed)

View the Evidence:
288 Abstracts with Nigella sativa (aka Black Seed) Research