Nigella sativa (aka Black Seed)

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206 Diseases Researched for Nigella sativa (aka Black Seed)
NameACCKFocus
Obesity562Locked
Oxidative Stress2558Locked
Diabetes Mellitus: Type 2850Locked
Hypertension739Locked
Asthma837Locked
Helicobacter Pylori Infection431Locked
Hyperglycemia425Locked
Lipid Peroxidation1325Locked
Insulin Resistance424Locked
Rheumatoid Arthritis423Locked
High Cholesterol222Locked
Inflammation922Locked
Triglycerides: Elevated221Locked
Allergic Rhinitis220Locked
Cardiovascular Disease: Prevention120Locked
Chemotherapy and Radiation Toxicity620Locked
Dyspepsia220Locked
Hashimoto's thyroiditis220Locked
Hyperlipidemia619Locked
Chemically-Induced Liver Damage816Locked
Cognitive Decline/Dysfunction416Locked
Memory Disorders516Locked
Chemotherapy-Induced Toxicity: Cisplatin714Locked
Diabetic Complications814Locked
Diabetic Nephropathy314Locked
Dyslipidemias414Locked
Wound Healing314Locked
Drug-Induced Toxicity: Methotrexate313Locked
Kidney Stones313Locked
Liver Cancer613Locked
Chemical Weapon Agent Injury 212Locked
Cholesterol: LDL/HDL ratio212Locked
Diabetes: Oxidative Stress612Locked
HDL: Low212Locked
Metabolic Diseases212Locked
Rhinosinusitis212Locked
Hepatitis C211Locked
A1C110Locked
Acute lymphoblastic leukemia (ALL)110Locked
Breast Cancer510Locked
C-Reactive Protein110Locked
Chemotherapy-Induced Toxicity: Gentamicin510Locked
Cholesterol: High110Locked
Diabetes: Glycation/A1C110Locked
Diabetic Ulcer110Locked
Eosinophilia110Locked
Epilepsy: Childhood110Locked
Infertility: Male110Locked
Mastalgia110Locked
Metabolic Syndrome X110Locked
Nonalcoholic fatty liver disease (NAFLD)110Locked
Opiate Addiction/Withdrawal110Locked
Osteoarthritis110Locked
Osteoarthritis: Knee110Locked
Pharyngitis110Locked
Sickle Cell Anemia110Locked
Sperm Quality: Low110Locked
Tonsillitis110Locked
Vitiligo110Locked
Acetaminophen (Tylenol) Toxicity 48Locked
Cancers: All88Locked
Ischemia58Locked
Kidney Damage58Locked
Neurodegenerative Diseases68Locked
Colon Cancer47Locked
Alcohol Toxicity 36Locked
Cervical Cancer26Locked
Endothelial Dysfunction36Locked
Hyperinsulinism36Locked
Lead Poisoning36Locked
Lipopolysaccharide-Induced Toxicity36Locked
Osteoporosis36Locked
Pain46Locked
Staphylococcus aureus: Methicillin-resistant (MRSA)26Locked
Fibrosis35Locked
Hydrogen Peroxide Induced Toxicity15Locked
Multiple Sclerosis35Locked
Alzheimer's Disease44Locked
Brain: Oxidative Stress24Locked
Cadmium Poisoning 24Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide24Locked
Chronic Pain24Locked
Diabetes Mellitus: Type 124Locked
Epilepsy34Locked
Gastritis24Locked
Hypothyroidism24Locked
Kidney Cancer24Locked
Liver Damage34Locked
Menopausal Syndrome24Locked
Morphine Tolerance/Dependence24Locked
Pulmonary Fibrosis: Bleomycin-Induced24Locked
Schistosomiasis24Locked
Seizures24Locked
Staphylococcus aureus infection44Locked
Chemotherapy-Induced Toxicity: Doxorubicin23Locked
Escherichia coli Infections33Locked
Fungal Infection23Locked
Gastric Ulcer23Locked
HIV Infections13Locked
Hypoglycemia23Locked
Salmonella Infections33Locked
Abdominal Adhesions12Locked
Aflatoxicosis12Locked
Aging12Locked
Allergies22Locked
Anxiety12Locked
Aspirin-Induced Toxicity 12Locked
Asthma: Bronchial22Locked
Bacillus Cereus infection22Locked
Bacillus subtilis infections22Locked
Breast Cancer: Chemically-Induced12Locked
Cancers: Radiation-Induced12Locked
Candidiasis12Locked
Cataract: Radiation-Induced12Locked
Central Nervous System Diseases22Locked
Cerebral Hypoperfusion12Locked
Cerebral Ischemia12Locked
Chemotherapy-Induced Toxicity: Kidney12Locked
Chemotherapy-Induced Toxicity: Tamoxifen12Locked
Cholestasis12Locked
Corticosteroid-Induced Toxicity12Locked
Cytomegalovirus Infections12Locked
DNA damage12Locked
Dementia12Locked
Diabetic Microangiopathy12Locked
Diabetic Neuropathies12Locked
Diabetic Neuropathy12Locked
Diarrhea12Locked
Drug-Induced Toxicity 12Locked
Drug-Induced Toxicity: Cyclosporine12Locked
Drug-Induced Toxicity: Gastrointestinal12Locked
Encephalomyelitis12Locked
Fatigue: Excercise-Induced12Locked
Food Allergies12Locked
Formaldehyde Toxicity12Locked
Fructose-Induced Toxicity 12Locked
Gram-Negative Bacterial Infections22Locked
Gram-Positive Bacterial Infections22Locked
HIV Drug-Induced Toxicity 12Locked
Hearing Loss: Noise-Induced12Locked
High Fat Diet12Locked
High Fructose Diet12Locked
High Homocysteine12Locked
Hypercholesterolemia12Locked
Inflammatory Bowel Diseases12Locked
Intestinal Ischemia12Locked
Keratitis12Locked
Kidney Cancer: Prevention12Locked
Kidney Damage: Chemically-Induced12Locked
Kidney Damage: Drug-Induced12Locked
Kidney Fibrosis12Locked
Learning disorders12Locked
Liver Damage: Aflatoxin-Induced12Locked
Lung Cancer12Locked
Lung Damage12Locked
Mucosal Damage: Radiation Induced12Locked
Myocardial Fibrosis 12Locked
Osteopenia12Locked
Ovarian Failure12Locked
Pancreatic Cancer22Locked
Parkinson's Disease22Locked
Pesticide Toxicity 12Locked
Postmenopausal Disorders12Locked
Prenatal Chemical Exposures12Locked
Radiation Induced Illness: Mucositis12Locked
Sodium nitrate toxicity12Locked
Spinal Cord Injuries12Locked
Stomach Cancer12Locked
Toxoplasma gondii Infection12Locked
Toxoplasmosis12Locked
Traumatic Brain Injury22Locked
Ulcerative Colitis12Locked
Urolithiasis12Locked
Autoimmune Diseases11Locked
Bacterial Infections11Locked
Bacterial Infections: Resistance/Biofilm Formation11Locked
Blastocystis hominis infections11Locked
Brain Ischemia11Locked
Breast Milk: Inadequate/Poor Quality11Locked
Cancer Metastasis11Locked
Cardiovascular Diseases11Locked
Chemotherapy-Induced Kidney Damage11Locked
Chronic Obstructive Pulmonary Disease11Locked
Clostridium Infections11Locked
Cough11Locked
Depression11Locked
Diabetes11Locked
Histamine: Elevated11Locked
Hodgkin Lymphoma11Locked
Hypersensitivity: Respiratory11Locked
Infection: Antibiotic Resistant11Locked
Kidney Diseases11Locked
Klebsiella Infections11Locked
Leishmaniasis11Locked
Liver Disease11Locked
Liver Diseases11Locked
Lung Diseases11Locked
Lymphoma11Locked
MRSA11Locked
Nephrolithiasis11Locked
Neurotoxicity11Locked
Pseudomonas aeruginosa11Locked
Pulmonary Emphysema11Locked
Respiratory Diseases11Locked
Rheumatism11Locked
Ulcers11Locked
84 Pharmacological Actions Researched for Nigella sativa (aka Black Seed)
NameACCKFocus
Antioxidants67142Locked
Hypoglycemic Agents1899Locked
Anti-Inflammatory Agents3180Locked
Hypolipidemic1780Locked
Antihypertensive Agents950Locked
Chemoprotective Agents1945Locked
Hepatoprotective1842Locked
Neuroprotective Agents2342Locked
Anticholesteremic Agents535Locked
Renoprotective1833Locked
Anti-Bacterial Agents931Locked
Malondialdehyde Down-regulation1530Locked
Analgesics829Locked
Immunomodulatory727Locked
Superoxide Dismutase Up-regulation1027Locked
Antiproliferative 1122Locked
Bronchodilator Agents322Locked
Apoptotic1321Locked
Anti-Ulcer Agents619Locked
Insulin Sensitizers416Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor416Locked
Anticarcinogenic Agents814Locked
Gastroprotective714Locked
Radioprotective714Locked
Anti-Apoptotic712Locked
Chemotherapeutic312Locked
Vascular Endothelial Growth Factor Inhibitors212Locked
Chemopreventive611Locked
NF-kappaB Inhibitor211Locked
Fertility Agents: Male110Locked
Hypotensive110Locked
anti-inflammatory110Locked
Anti-Fibrotic48Locked
Pancreato Protective Agents48Locked
Antiviral Agents47Locked
Nitric Oxide Inhibitor47Locked
Tumor Suppressor Protein p53 Upregulation37Locked
Anticonvulsants46Locked
Antifungal Agents56Locked
Antimicrobial66Locked
Antineoplastic Agents26Locked
Anti-metastatic45Locked
Caspase-3 Activation15Locked
Caspase-8 activation15Locked
Caspase-9 Activation15Locked
Angiogenesis Inhibitors34Locked
Antiparasitic Agents34Locked
Cytoprotective24Locked
Antinoceceptive 23Locked
Interleukin-6 Downregulation23Locked
Acetylcholinesterase Inhibitor12Locked
Analgesics: Non-Narcotic12Locked
Anti-Anxiety Agents12Locked
Anticholinergic12Locked
Cyclooxygenase 2 Inhibitors22Locked
Genoprotective12Locked
Gluconeogenesis Inhibitor12Locked
Heme oxygenase-1 up-regulation12Locked
Histamine Antagonists12Locked
Histamine down-regulation22Locked
Insulin-releasing12Locked
Interferon Inducers12Locked
Interleukin-1 beta downregulation12Locked
MicroRNA modulator12Locked
Osteoprotective 12Locked
Prophylactic Agents12Locked
Remyelination12Locked
Vascular Endothelial Growth Factor A Inhibitor12Locked
Vasodilator Agents12Locked
Anti-Allergic Agents11Locked
Anti-Asthmatic Agents11Locked
Antidepressive Agents11Locked
Antispasmodic11Locked
Antitussive Agents11Locked
Bcl-2 protein down-regulation11Locked
Cardioprotective11Locked
Cyclooxygenase 1 Inhibitor11Locked
Galactogogue11Locked
Gastrointestinal Agents11Locked
Leishmanicidal11Locked
Leukotriene Antagonists11Locked
Leukotriene D4 antagonist11Locked
Postaglandin PGE2 downregulation 11Locked
STAT3 Inhibitor11Locked
Related Topics

Nigella sativa (aka Black Seed) is a Sub of the following Topics

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View the Evidence:
356 Abstracts with Nigella sativa (aka Black Seed) Research

[+]

A systematic review and meta-analysis of the effect of Nigella sativa supplementation on obesity indices.May 31, 2018

Pubmed Data : Complement Ther Med. 2018 Jun ;38:48-57. Epub 2018 Apr 11. PMID: 29857879
Article Published Date : May 31, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Current findings suggest N. sativa supplementation a suitable choice in managing the complications of T2D.Nov 30, 2017

Pubmed Data : Complement Ther Med. 2017 Dec ;35:6-13. Epub 2017 Aug 30. PMID: 29154069
Article Published Date : Nov 30, 2017
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic
[+]

Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress.May 10, 2020

Pubmed Data : Phytother Res. 2020 May 11. Epub 2020 May 11. PMID: 32394508
Article Published Date : May 10, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hyperglycemia, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Hypoglycemic Agents, Hypolipidemic
[+]

N. sativa consumption has a significant lowering effect on glycemic status.Mar 13, 2019

Pubmed Data : Phytother Res. 2019 Mar 14. Epub 2019 Mar 14. PMID: 30873688
Article Published Date : Mar 13, 2019
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

Nigella Sativa has a significant impact on plasma lipid concentrations, leading to lower total cholesterol.Feb 09, 2016

Pubmed Data : Pharmacol Res. 2016 Feb 10. Epub 2016 Feb 10. PMID: 26875640
Article Published Date : Feb 09, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cardiovascular Disease: Prevention, High Cholesterol, Triglycerides: Elevated
Pharmacological Actions : Anticholesteremic Agents
[+]

Nigella sativa supplementation may provide additional benefits for the treatment of asthma.Nov 28, 2019

Pubmed Data : Am J Emerg Med. 2019 Nov 29. Epub 2019 Nov 29. PMID: 31892440
Article Published Date : Nov 28, 2019
Study Type : Meta Analysis
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents
[+]

Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19.Dec 31, 2019

Pubmed Data : Am J Blood Res. 2020 ;10(5):266-282. Epub 2020 Oct 15. PMID: 33224571
Article Published Date : Dec 31, 2019
Study Type : Meta Analysis, Review
Additional Links
Substances : Chamomile, Honey, Nigella sativa (aka Black Seed)
Diseases : Coronavirus Infection
Pharmacological Actions : Prophylactic Agents
[+]

Supplementation with N. sativa exerts a moderate effect on reduction in body weight, body mass index and waist circumference.Mar 16, 2018

Pubmed Data : J Ethnopharmacol. 2018 Mar 17. Epub 2018 Mar 17. PMID: 29559374
Article Published Date : Mar 16, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

This meta-analysis suggests that Nigella sativa supplementation in humans may benefit as an antioxidant.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2020 ;2020:2390706. Epub 2020 May 6. PMID: 32454800
Article Published Date : Dec 31, 2019
Study Type : Meta Analysis
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
[+]

This meta-analysis suggests that short-term treatment with N. sativa powder can significantly reduce SBP and DBP levels.Aug 09, 2016

Pubmed Data : J Hypertens. 2016 Aug 10. Epub 2016 Aug 10. PMID: 27512971
Article Published Date : Aug 09, 2016
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

This meta-analysis suggests thatN. sativa seed and seed oil supplementation can significantly reduce serum CRP level.Jul 31, 2019

Pubmed Data : Complement Ther Med. 2019 Aug ;45:149-155. Epub 2019 Jun 14. PMID: 31331553
Article Published Date : Jul 31, 2019
Study Type : Meta Analysis, Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : C-Reactive Protein (CRP), Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

A randomized controlled trial of a herbal compound for improving metabolic parameters in diabetic patients with uncontrolled dyslipidemia.Feb 05, 2019

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 Feb 6. Epub 2019 Feb 6. PMID: 30727929
Article Published Date : Feb 05, 2019
Study Type : Human Study
Additional Links
Substances : Aloe Vera, Fenugreek, Milk Thistle, Nigella sativa (aka Black Seed), Psyllium
Diseases : Diabetes Mellitus: Type 2, Dyslipidemias
Pharmacological Actions : Hypolipidemic
[+]

Black cumin (Nigella sativa) and Phyllanthus niruri provide symptomatic relief in the treatment of acute tonsillo-pharyngitis patients.Jun 01, 2008

Pubmed Data : Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306. PMID: 18541126
Article Published Date : Jun 01, 2008
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Phyllanthus niruri (Stonebreaker)
Diseases : Pharyngitis, Tonsillitis
Additional Keywords : Plant Extracts
[+]

Black cumin (Nigella sativa) has a prophylactic effect on chemical war victims. Nov 01, 2008

Pubmed Data : J Altern Complement Med. 2008 Nov;14(9):1137-44. PMID: 18991514
Article Published Date : Nov 01, 2008
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemical Weapon Agent Injury
[+]

Black cumin (Nigella sativa) is effective in long-term treatment of opioid dependence. Apr 01, 2008

Pubmed Data : J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):118-24. PMID: 19385474
Article Published Date : Apr 01, 2008
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Opiate Addiction/Withdrawal
[+]

Black cumin alleviates symptoms of allergic rhinitis. Oct 12, 2010

Pubmed Data : Am J Otolaryngol. 2010 Oct 12. Epub 2010 Oct 12. PMID: 20947211
Article Published Date : Oct 12, 2010
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Allergic Rhinitis
[+]

Black cumin possesses clinical useful anti-H. pylori activity compared to triple therapy.Jul 01, 2010

Pubmed Data : Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. PMID: 20616418
Article Published Date : Jul 01, 2010
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Dyspepsia, Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents, Anti-Ulcer Agents
Additional Keywords : Drug: Amoxicillin, Drug: Omeprazole, Drug-Plant-Vitamin Synergies, Natural Substances Versus Drugs, Plant Extracts
[+]

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Pubmed Data : Infect Disord Drug Targets. 2015 Mar 20. Epub 2015 Mar 20. PMID: 25809628
Article Published Date : Mar 19, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acute lymphoblastic leukemia (ALL), Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Chemotherapeutic, Hepatoprotective
Additional Keywords : Natural Substance/Drug Synergy
[+]

Black cumin seeds have significant anti-diabetic effects in type 2 diabetics. Oct 01, 2010

Pubmed Data : Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54. PMID: 21675032
Article Published Date : Oct 01, 2010
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : A1C, Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers
Additional Keywords : Beta Cell Protection, Beta Cell Regeneration
[+]

Black cumin seeds improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto's thyroiditis.Mar 26, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2018 Mar 27 ;17(1):59. Epub 2018 Mar 27. PMID: 29587770
Article Published Date : Mar 26, 2018
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hashimoto's thyroiditis
Pharmacological Actions : Hypolipidemic
[+]

Consumption of Nigella sativa can reduce the inflammatory biomarkers in patients with NAFLD.May 31, 2019

Pubmed Data : Complement Ther Med. 2019 Jun ;44:204-209. Epub 2019 Apr 22. PMID: 31126557
Article Published Date : May 31, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Daily intake of N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects.May 14, 2014

Pubmed Data : Phytomedicine. 2014 May 15 ;21(6):901-5. Epub 2014 Mar 25. PMID: 24680621
Article Published Date : May 14, 2014
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Infertility: Male, Sperm Quality: Low
Pharmacological Actions : Fertility Agents: Male
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Dosin eradicated H. pylori in about 57% of infected patients.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran Red Crescent Med J. 2016 Nov ;18(11):e23771. Epub 2016 Jun 21. PMID: 28191328
Article Published Date : Oct 31, 2016
Study Type : Human Study
Additional Links
Substances : Honey, Nigella sativa (aka Black Seed)
Diseases : Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

Effect of Nigella sativa oil extracts on inflammatory and oxidative stress markers in Behcet's disease.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2020 Mar-Apr;10(2):181-189. PMID: 32257890
Article Published Date : Feb 29, 2020
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Behcet Disease
Pharmacological Actions : Antioxidants, Malonaldehyde (MDA) Down-Regulation
[+]

Effectiveness of topical Nigella sativa for vitiligo treatment.Apr 24, 2019

Pubmed Data : Dermatol Ther. 2019 Apr 25:e12949. Epub 2019 Apr 25. PMID: 31025474
Article Published Date : Apr 24, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Vitiligo
[+]

Effects of resistance training and nigella sativa on type 2 diabetes.Feb 20, 2021

Pubmed Data : Arch Physiol Biochem. 2021 Feb 21:1-9. Epub 2021 Feb 21. PMID: 33612031
Article Published Date : Feb 20, 2021
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Therapeutic Actions : Exercise: Resistance Training
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

Honey and celery seeds could be beneficial in bronchial asthma.May 31, 2019

Pubmed Data : J Med Food. 2019 Jun ;22(6):543-550. Epub 2019 May 24. PMID: 31135254
Article Published Date : May 31, 2019
Study Type : Human Study
Additional Links
Substances : Celery seed, Honey, Nigella sativa (aka Black Seed)
Diseases : Asthma: Bronchial
Pharmacological Actions : Anti-Asthmatic Agents
[+]

It is recommended that clinicians and wound care nurses use aloe vera gel instead of Nigella sativa oil gel for the topical treatment of diabetic ulcers.Dec 31, 2017

Pubmed Data : J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18772804. PMID: 29717629
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Aloe Vera, Nigella sativa (aka Black Seed)
Diseases : Diabetic Ulcer, Wound Healing
[+]

N sativa supplementation with inhaled maintenance therapy improves some measures of pulmonary function and inflammation in partly controlled asthma.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. PMID: 28151459
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma
Pharmacological Actions : Bronchodilator Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients.Apr 27, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Article Published Date : Apr 27, 2013
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hepatitis C
[+]

N. sativa could be a promising, safe, and easily available analgesic supplement in women suffering from primary dysmenorrhea.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oman Med J. 2020 Sep ;35(5):e167. Epub 2020 Sep 9. PMID: 32953142
Article Published Date : Aug 31, 2020
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Dysmenorrhea
Pharmacological Actions : Analgesics
[+]

N. sativa extract significantly decreases the severity of acute radiation dermatitis and delays the onset of moist desquamation in breast cancer patients.Nov 30, 2019

Pubmed Data : Complement Ther Med. 2019 Dec ;47:102205. Epub 2019 Oct 3. PMID: 31780017
Article Published Date : Nov 30, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Breast Cancer, Chemotherapy and Radiation Toxicity, Dermatitis
Pharmacological Actions : Radioprotective
[+]

N. sativa hydrogel had significant effects on improving the symptoms of acne vulgaris with acceptable tolerability. Jun 16, 2020

Pubmed Data : Phytother Res. 2020 Jun 17. Epub 2020 Jun 17. PMID: 32548864
Article Published Date : Jun 16, 2020
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acne
Pharmacological Actions : Anti-Bacterial Agents
[+]

N. sativa is demonstrated to have significant positive effects on disappearance or reduction of size of kidney stones.Mar 13, 2019

Pubmed Data : Phytother Res. 2019 Mar 14. Epub 2019 Mar 14. PMID: 30873671
Article Published Date : Mar 13, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Kidney Stones
[+]

N. sativa oil supplementation along with alpha-keto analogue is efficacious and safe in delaying the progression of disease patients with CKD Stages 3 and 4.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Kidney Dis Transpl. 2020 Jan-Feb;31(1):21-31. PMID: 32129194
Article Published Date : Dec 31, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chronic Kidney Disease (CKD)
Pharmacological Actions : Renoprotective
Additional Keywords : Risk Reduction
[+]

N. sativa oil was found to be effective as an add-on therapy in patients of insulin resistance syndrome.Dec 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Diabetes Dev Ctries. 2008 Jan ;28(1):11-4. PMID: 19902033
Article Published Date : Dec 31, 2007
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Insulin Resistance
Pharmacological Actions : Anticholesteremic Agents, Hypoglycemic Agents
[+]

N. sativa seed oil has clinical effectiveness comparable to topical diclofenac in the treatment of cyclic mastalgia.Nov 18, 2015

Pubmed Data : Planta Med. 2015 Nov 19. Epub 2015 Nov 19. PMID: 26584456
Article Published Date : Nov 18, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Mastalgia
Pharmacological Actions : Analgesics
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Diclofenac
[+]

N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Princ Pract. 2010 ;19(3):206-11. Epub 2010 Mar 29. PMID: 20357504
Article Published Date : Dec 31, 2009
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Allergic Rhinitis
Pharmacological Actions : Immunomodulatory
Additional Keywords : Phytotherapy, Significant Treatment Outcome
[+]

N. sativa seeds is beneficial in relieving the symptoms of knee osteoarthritis.Apr 04, 2017

Pubmed Data : Int J Rheum Dis. 2017 Apr 5. Epub 2017 Apr 5. PMID: 28378356
Article Published Date : Apr 04, 2017
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Osteoarthritis
Additional Keywords : Significant Treatment Outcome
[+]

Nigella sativa (black cumin) has potent antiasthmatic properties. Feb 08, 2010

Pubmed Data : Phytomedicine. 2010 Feb 8. Epub 2010 Feb 8. PMID: 20149611
Article Published Date : Feb 08, 2010
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma
Pharmacological Actions : Bronchodilator Agents
[+]

Nigella sativa could improve inflammation and reduce oxidative stress in patients with rheumatoid arthritis.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):34-43. PMID: 27247920
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Nigella sativa enhances memory, attention and cognition in healthy human volunteers.Jul 29, 2013

Pubmed Data : J Ethnopharmacol. 2013 Jul 30 ;148(3):780-6. Epub 2013 May 21. PMID: 23707331
Article Published Date : Jul 29, 2013
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
[+]

Nigella sativa oil concurrent with a low-calorie diet decreased weight and increased SOD levels in obese women.Jul 13, 2015

Pubmed Data : Phytother Res. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26179113
Article Published Date : Jul 13, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Obesity, Oxidative Stress
Therapeutic Actions : Dietary Modification: Low Calorie Diet
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
[+]

Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:3619357. Epub 2019 Oct 30. PMID: 31781612
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acute Myeloid Leukemia, Radiation Induced Illness: Mucositis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Radioprotective
[+]

Nigella sativa oil supplement has cardiovascular protective effects in patients with T2DM.Jun 07, 2020

Pubmed Data : Phytother Res. 2020 Jun 8. Epub 2020 Jun 8. PMID: 32510754
Article Published Date : Jun 07, 2020
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : C-Reactive Protein, Cardiovascular Diseases, Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Antioxidants, Cardioprotective, Hypoglycemic Agents, Hypolipidemic
[+]

Nigella sativa oil supplementation combined with a calorie-restricted diet may modulate systemic inflammatory biomarkers in obese women.Aug 31, 2016

Pubmed Data : J Clin Lipidol. 2016 Sep-Oct;10(5):1203-11. Epub 2015 Dec 7. PMID: 27678438
Article Published Date : Aug 31, 2016
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Obesity
Therapeutic Actions : Dietary Modification: Low Calorie Diet
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Plant Oils
[+]

Nigella sativa oil supplementation had a protective effect in diabetic nephropathy.Dec 31, 2016

Pubmed Data : Saudi J Kidney Dis Transpl. 2017 Jan-Feb;28(1):9-14. PMID: 28098097
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetic Nephropathy
Pharmacological Actions : Hypoglycemic Agents
[+]

Nigella sativa seed oil supplements may decrease the liver enzymes and lipid profiles in the patients with NAFLD.Nov 30, 2019

Pubmed Data : J Diabetes Metab Disord. 2019 Dec ;18(2):453-459. Epub 2019 Sep 11. PMID: 31890671
Article Published Date : Nov 30, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nigella sativa seeds can be considered as a therapeutic agent in management of Hashimoto-related metabolic abnormalities.May 31, 2020

Pubmed Data : Clin Nutr ESPEN. 2020 Jun ;37:207-212. Epub 2020 Mar 10. PMID: 32359745
Article Published Date : May 31, 2020
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Endothelial Dysfunction, Hashimoto's thyroiditis
Pharmacological Actions : Antioxidants
[+]

Nigella sativa seeds powder may be of interest in lowering lipid concentrations in hyperlipidemic subjects.Mar 14, 2019

Pubmed Data : Br J Clin Pharmacol. 2019 Mar 15. Epub 2019 Mar 15. PMID: 30875097
Article Published Date : Mar 14, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic
[+]

Nigella sativa seeds showed a decrease in incidence of febrile neutropenia in children with brain tumors undergoing chemotherapy.Mar 26, 2017

Pubmed Data : Childs Nerv Syst. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28349493
Article Published Date : Mar 26, 2017
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Risk Reduction, Significant Treatment Outcome
[+]

Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial.Jan 16, 2017

Pubmed Data : Phytother Res. 2017 Jan 17. Epub 2017 Jan 17. PMID: 28093815
Article Published Date : Jan 16, 2017
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma, Eosinophilia
Pharmacological Actions : anti-inflammatory
Additional Keywords : anti-inflammatory, Asthma, Black Seed, Eosinophilia, Nigella sativa oil (NSO)
[+]

Powdered Nigella sativa has potent beneficial effects in improving thyroid status and anthropometric variables.Nov 15, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Nov 16 ;16(1):471. Epub 2016 Nov 16. PMID: 27852303
Article Published Date : Nov 15, 2016
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hashimoto's thyroiditis
Pharmacological Actions : Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Plant Extracts
[+]

Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal WomenDec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2014 ;4(1):29-33. Epub 2013 Dec 23. PMID: 24409406
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cholesterol: High, Cholesterol: LDL/HDL ratio, HDL: Low, Metabolic Syndrome X
[+]

Supplementation of honey and N. sativa can cause significant symptomatic improvement of patients with functional dyspepsia whom received the standard anti-secretory therapy.Sep 15, 2015

Pubmed Data : J Ethnopharmacol. 2015 Sep 16. Epub 2015 Sep 16. PMID: 26386381
Article Published Date : Sep 15, 2015
Study Type : Human Study
Additional Links
Substances : Honey, Nigella sativa (aka Black Seed)
Diseases : Dyspepsia, Helicobacter Pylori Infection
[+]

The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients.Jan 08, 2020

Pubmed Data : Phytother Res. 2020 Jan 9. Epub 2020 Jan 9. PMID: 31916648
Article Published Date : Jan 08, 2020
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Dyspepsia, Helicobacter Pylori Infection
Pharmacological Actions : Anti-Bacterial Agents
[+]

The combination of black seeds and turmeric can be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.Mar 31, 2015

Pubmed Data : Complement Ther Med. 2015 Apr ;23(2):165-74. Epub 2015 Jan 14. PMID: 25847554
Article Published Date : Mar 31, 2015
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Turmeric
Diseases : Metabolic Diseases
Pharmacological Actions : Antihypertensive Agents, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Natural Substance Synergy, Significant Treatment Outcome
[+]

The daily use of black cumin seeds for 2 months may have a blood pressure-lowering effect in patients with mild hypertension. Apr 01, 2006

Pubmed Data : Braz J Med Biol Res. 2006 Apr;39(4):421-9. Epub 2006 Apr 3. PMID: 18705755
Article Published Date : Apr 01, 2006
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Hypotensive
Additional Keywords : Plant Extracts
[+]

The fixed oil extracted from Nigella sativa seeds has an in vitro antisickling activity.Feb 28, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Singapore Med J. 2010 Mar ;51(3):230-4. PMID: 20428745
Article Published Date : Feb 28, 2010
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Sickle Cell Anemia
Additional Keywords : Plant Oils
[+]

The use of N. sativa nasal spray has symptom reliever effect with no adverse effects in patients.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718800059. Epub 2018 Oct 4. PMID: 30370173
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Rhinosinusitis
Additional Keywords : Significant Treatment Outcome
[+]

The water extract of black cumin seed has significant anti-epileptic activity in children.Dec 01, 2007

Pubmed Data : Med Sci Monit. 2007 Dec;13(12):CR555-9. PMID: 18049435
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Epilepsy: Childhood
[+]

This study gives strength to the potential relevance of Nigella sativa in clinical management of rheumatoid arthritis.Apr 30, 2016

Pubmed Data : Immunol Invest. 2016 May ;45(4):271-83. Epub 2016 Apr 21. PMID: 27100726
Article Published Date : Apr 30, 2016
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : C-Reactive Protein, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Topical application of N. sativa oil is effective in the prevention of chemotherapy-induced phlebitis.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2019 Sep ;9(3):20. Epub 2019 Aug 27. PMID: 31453801
Article Published Date : Aug 31, 2019
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Phlebitis (CIP)
Pharmacological Actions : Chemoprotective Agents
[+]

Topical application of Nigella sativa oil was effective in reducing pain in patients with knee osteoarthritis.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Electron Physician. 2016 Nov ;8(11):3193-3197. Epub 2016 Nov 25. PMID: 28344755
Article Published Date : Oct 31, 2016
Study Type : Human Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Analgesics
[+]

A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-foldJan 31, 2013

Pubmed Data : Nat Prod Commun. 2013 Feb ;8(2):213-6. PMID: 23513732
Article Published Date : Jan 31, 2013
Study Type : Human In Vitro
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

Black seed, sweet orange, and Anthemis hyalina extracts all exhibit antiviral activity against coronavirus.Mar 01, 2014

Pubmed Data : Mol Biol Rep. 2014 Mar ;41(3):1703-11. Epub 2014 Jan 12. PMID: 24413991
Article Published Date : Mar 01, 2014
Study Type : Human In Vitro
Additional Links
Substances : Nigella sativa (aka Black Seed), Sweet Orange
Diseases : Coronavirus Disease, Coronavirus Infection, Severe Acute Respiratory Syndrome
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
[+]

N. sativa oil could be used against multi-drug resistant S. aureus in the treatment of diabetic wounds.Oct 31, 2015

Pubmed Data : Pak J Pharm Sci. 2015 Nov ;28(6):1985-90. PMID: 26639493
Article Published Date : Oct 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Staphylococcus aureus: Methicillin-resistant (MRSA)
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Dose Response
[+]

Nigella sativa has successfully produced inhibition of growth of MCF cell lines with an equivalent potency as that of the standard cisplatin.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacognosy Res. 2015 Apr-Jun;7(2):193-7. PMID: 25829794
Article Published Date : Mar 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Breast Cancer, Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Natural Substances Versus Drugs, Superiority of Natural Substances versus Drugs
[+]

Thymoquinone-rich fractions of Nigella sativa could be an alternative to combat oxidative stress insults in neurodegenerative diseases.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:2528935. Epub 2015 Dec 28. PMID: 26823946
Article Published Date : Dec 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Gene Expression Regulation, Plant Extracts
[+]

Nigella Sativa Concoction Induced Sustained Seroreversion in HIV Patient.Dec 31, 2012

Pubmed Data :
PMID: 24311845
Article Published Date : Dec 31, 2012
Study Type : Human: Case Report
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : HIV Infections
Pharmacological Actions : Antiviral Agents, Immunomodulatory
[+]

"Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors."Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(6):e39841. Epub 2012 Jun 29. PMID: 22768141
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diarrhea, Food Allergies
Additional Keywords : Phytotherapy, Plant Extracts
[+]

A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats.Jan 31, 2015

Pubmed Data : J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID: 25384193
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Turmeric
Diseases : Dyslipidemias, Endothelial Dysfunction, Fructose-Induced Toxicity , Hyperglycemia, Hyperinsulinism, Hypertension, Metabolic Diseases
Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Natural Substance Synergy, Risk Reduction
[+]

A hydro-alcoholic extract of nigella sativa reduced the LPS-induced sickness behaviors in rats.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):104-16. PMID: 27247927
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Lipopolysaccharide-Induced Toxicity
Additional Keywords : Plant Extracts
[+]

A hydroalcoholic extract of the Nigella sativa decreased oxidative stress in hippocampus of the STZ-induced diabetic rats.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2015 Jul-Aug;5(4):333-40. PMID: 26445713
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Brain: Oxidative Stress, Diabetic Complications
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

A liposomal preparation of black seed oil demonstrated significant analgesic activity in mice.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2017 Mar ;25(3):404-412. Epub 2016 Oct 1. PMID: 28344496
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Liposomal
[+]

A plant mixture comprising Nigella sativa, Myrrh, Gum Olibanum (Frankincense), Gum Asafoetida and Aloe lowers blood sugar by inhibiting hepatis gluconeogenesis. Dec 01, 1991

Pubmed Data : Diabetes Res. 1991 Dec;18(4):163-8. PMID: 1842751
Article Published Date : Dec 01, 1991
Study Type : Animal Study
Additional Links
Substances : Aloe Vera, Asafoetida, Frankincense, Myrrh, Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Gluconeogenesis Inhibitor
Additional Keywords : Plant Extracts
[+]

A thymoquinone-rich fraction extracted from Nigella sativa effectively improved the plasma and liver antioxidant capacity.Feb 28, 2010

Pubmed Data : Free Radic Biol Med. 2010 Mar 1 ;48(5):664-72. Epub 2009 Dec 11. PMID: 20005291
Article Published Date : Feb 28, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypercholesterolemia
Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation
Additional Keywords : Gene Expression Regulation
[+]

Active components in Nigella sativa and Olive oil may prove useful in treating impaired cognition.Nov 20, 2016

Pubmed Data : Nutr Neurosci. 2016 Nov 21:1-10. Epub 2016 Nov 21. PMID: 27868798
Article Published Date : Nov 20, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Olive Oil
Diseases : Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

Administration of either nigella sativa oil counteracts dexamethasone induced-gastric lesions.Feb 09, 2017

Pubmed Data : Can J Physiol Pharmacol. 2017 Feb 10. Epub 2017 Feb 10. PMID: 28187265
Article Published Date : Feb 09, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Corticosteroid-Induced Toxicity
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective, Malondialdehyde Down-regulation
[+]

Administration of melatonin, retinoic acid and Nigella sativa reduced the carcinogenic effects of DMBA.Nov 30, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Exp Pathol. 2005 Dec ;86(6):383-96. PMID: 16309544
Article Published Date : Nov 30, 2005
Study Type : Animal Study
Additional Links
Substances : Melatonin, Nigella sativa (aka Black Seed), Vitamin A
Diseases : Breast Cancer, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Metabolites, Phytotherapy, Plant Extracts
[+]

Administration of Nigella sativa can be used to prevent formaldehyde induced apoptosis and epithelial damage.Apr 30, 2017

Pubmed Data : Niger J Clin Pract. 2017 May ;20(5):523-529. PMID: 28513508
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Formaldehyde Toxicity
Pharmacological Actions : Anti-Apoptotic, Cytoprotective
Problem Substances : Formaldehyde
[+]

Administration of Nigella sativa seed oil exerts a protective effect against urolithiasis.Dec 31, 2015

Pubmed Data : Afr J Tradit Complement Altern Med. 2016 ;13(6):204-214. Epub 2016 Sep 29. PMID: 28480381
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Urolithiasis
[+]

Ameliorative effect of Nigella sativa oil and vitamin C on the thyroid gland and cerebellum.Sep 30, 2020

Pubmed Data : Tissue Cell. 2020 Oct ;66:101391. Epub 2020 Jun 8. PMID: 32933714
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Vitamin C
Diseases : Thyroid Diseases
Pharmacological Actions : Neuroprotective Agents
[+]

Antimalarial activity of Nigella sativa seed extracts.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pathog. 2021 ;2021:6165950. Epub 2021 Feb 3. PMID: 33623718
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Malaria
Pharmacological Actions : Antimalarials
[+]

Black cumin exhibit significant antifungal activity against candidasis in mice. Feb 01, 2003

Pubmed Data : Phytother Res. 2003 Feb;17(2):183-6. PMID: 12601685
Article Published Date : Feb 01, 2003
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Candidiasis, Fungal Infection
Pharmacological Actions : Antifungal Agents
Additional Keywords : Plant Extracts
[+]

Black cumin extract reduces the damage caused by cadmium poisoning in rats.May 01, 2006

Pubmed Data : Biol Trace Elem Res. 2006 May;110(2):151-62. PMID: 16757843
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cadmium Poisoning
[+]

Black Cumin improves blood lipid profiles.Oct 04, 2010

Pubmed Data : Neurosci Lett. 2010 Oct 4;482(3):183-7. Epub 2010 Jun 11. PMID: 16092657
Article Published Date : Oct 04, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cholesterol: LDL/HDL ratio, HDL: Low, High Cholesterol
[+]

Black cumin may have antidiabetic effects by increasing insulin sensitivity. Jan 01, 2011

Pubmed Data : Evid Based Complement Alternat Med. 2011;2011:538671. Epub 2011 Apr 14. PMID: 21584245
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Black cumin oil decreased the proinflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis.Feb 28, 2011

Pubmed Data : Dig Dis Sci. 2011 Mar ;56(3):721-30. Epub 2010 Jul 24. PMID: 20658190
Article Published Date : Feb 28, 2011
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Oxidative Stress, Ulcerative Colitis
Pharmacological Actions : Antioxidants, Hypolipidemic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Oils
[+]

Black cumin protects against chemical weapon agent induced lung injury. May 01, 2008

Pubmed Data : Exp Lung Res. 2008 May;34(4):183-94. PMID: 18432455
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemical Weapon Agent Injury
Additional Keywords : Plant Extracts
[+]

Black cumin seed oil has significant protective activity against cytomegalovirus infection in the mouse experimental model. Sep 01, 2000

Pubmed Data : Int J Immunopharmacol. 2000 Sep;22(9):729-40. PMID: 10884593
Article Published Date : Sep 01, 2000
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cytomegalovirus Infections
Pharmacological Actions : Antiviral Agents, Interferon Inducers
[+]

Black cumin's hyperglycemic activity in the rat model of diabetes may be due to beta cell regeneration/proliferation.Dec 01, 2003

Pubmed Data : Tohoku J Exp Med. 2003 Dec;201(4):213-9. PMID: 14690013
Article Published Date : Dec 01, 2003
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 1
Additional Keywords : Beta Cell Regeneration
[+]

Black seed oil exhibited an anti-aging effect in a model of aging induced with D-galactose.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2017 Mar ;20(1):29-35. PMID: 28392960
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Aging
Pharmacological Actions : Anti-Apoptotic, Antioxidants
[+]

Black seed oil has significant inhibitory effects against colon cancer in rats, without observable side effects.Jan 01, 2003

Pubmed Data : Nutr Cancer. 2003;45(2):195-202. PMID: 12881014
Article Published Date : Jan 01, 2003
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Black seed thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin-induced diabetic male wistar rats.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8104165. Epub 2018 Mar 4. PMID: 29686746
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Insulin-releasing
[+]

Bone marrow-derived mesenchymal stem cells and N.sativa ameliorate the histological, biochemical and immunohistochemical changes induced by energy drink.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Morphol (Warsz). 2019 Jul 1. Epub 2019 Jul 1. PMID: 31257565
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Pharmacological Actions : Pancreato Protective Agents
Additional Keywords : Mesenchymal Stem Cells
Problem Substances : Energy Drinks
[+]

Both Nigella sativa and date reduce the toxic effects of aflatoxin-B1 in liver and kidney.Jun 30, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Health Sci (Qassim). 2008 Jul ;2(2):26-44. PMID: 21475486
Article Published Date : Jun 30, 2008
Study Type : Animal Study
Additional Links
Substances : Dates, Nigella sativa (aka Black Seed)
Diseases : Liver Damage: Aflatoxin-Induced
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Aflatoxin
[+]

Both Nigella sativa and thymoquinone can partly protect gastric mucosa from acute alcohol-induced mucosal injury.Nov 13, 2005

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2005 Nov 14 ;11(42):6662-6. PMID: 16425361
Article Published Date : Nov 13, 2005
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Alcohol Toxicity
Pharmacological Actions : Gastroprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Both Nigella sativa fixed and essential oil are effective in improving the antioxidant indices against potassium bromate induced oxidative stress.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15(1):330. Epub 2015 Sep 18. PMID: 26385559
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Essential Oils
[+]

Both Nigella sativa oil and thymoquinone possess gastroprotective effect against gastric lesions.Jan 31, 2003

Pubmed Data : J Ethnopharmacol. 2003 Feb ;84(2-3):251-8. PMID: 12648823
Article Published Date : Jan 31, 2003
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Ischemia, Lipid Peroxidation
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Oils
[+]

Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis.Aug 31, 2019

Pubmed Data : J Musculoskelet Neuronal Interact. 2019 Sep 1 ;19(3):362-369. PMID: 31475944
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective
[+]

Chronic administration of N. sativa seed extract has a significant hypoglycemic effect.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):67-76. PMID: 27247923
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetic Complications, Endothelial Dysfunction
Pharmacological Actions : Hypoglycemic Agents
[+]

Cold-pressed Nigella Sativa oil standardized to 3% thymoquinone potentiates omega-3 protection against obesity.Jun 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jun 4 ;9(6). Epub 2020 Jun 4. PMID: 32512788
Article Published Date : Jun 03, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Omega-3 Fatty Acids, Thymoquinone
Diseases : Insulin Resistance, Obesity
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Anti-Obesity Agents
[+]

Comparative hepatoprotective effect of Nigella sativa pre- and post-treatment.Dec 31, 2018

Pubmed Data : Pak J Pharm Sci. 2019 Jan ;32(1):205-212. PMID: 30772810
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Prophylactic Agents
Problem Substances : Acetaminophen, Paracetamol
[+]

Covering peritoneal surfaces with nigella sativa oil after peritoneal trauma is effective in decreasing peritoneal adhesion formation.Oct 06, 2013

Pubmed Data : J Obstet Gynaecol Res. 2013 Oct 7. doi: 10.1111/jog.12172.
Article Published Date : Oct 06, 2013
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Abdominal Adhesions
[+]

Effects of Nigella sativa and human parathyroid hormone on bone mass and strength in diabetic rats.May 31, 2007

Pubmed Data : Biol Trace Elem Res. 2007 Jun ;116(3):321-8. PMID: 17709912
Article Published Date : May 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetic Complications, Osteoporosis
Pharmacological Actions : Osteoprotective
Additional Keywords : Plant Extracts
[+]

Effects of Nigella sativa oil and thymoquinone against bisphenol A-induced metabolic disorder.Dec 13, 2020

Pubmed Data : Phytother Res. 2020 Dec 14. Epub 2020 Dec 14. PMID: 33315269
Article Published Date : Dec 13, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Bisphenol Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Bisphenol A
[+]

Effects of Nigella sativa seed polysaccharides on type 2 diabetic mice and gut microbiota. May 07, 2020

Pubmed Data : Int J Biol Macromol. 2020 May 8 ;159:725-738. Epub 2020 May 8. PMID: 32437806
Article Published Date : May 07, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastrointestinal Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Polysaccharides
[+]

Efficient therapeutic effect of Nigella sativa aqueous extract and chitosan nanoparticles against experimentally induced acanthamoeba keratitis.May 28, 2019

Pubmed Data : Parasitol Res. 2019 May 29. Epub 2019 May 29. PMID: 31144032
Article Published Date : May 28, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Keratitis
Additional Keywords : Significant Treatment Outcome
[+]

Ethanolic extract of Nigella sativa possessed significant analgesic effect in mice.Jun 30, 2010

Pubmed Data : J Coll Physicians Surg Pak. 2010 Jul ;20(7):464-7. PMID: 20642947
Article Published Date : Jun 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chronic Pain
Pharmacological Actions : Analgesics
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Feeding of Nigella sativa during neonatal and juvenile growth improves learning and memory of rats.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2016 Apr ;6(2):146-52. Epub 2015 Jan 17. PMID: 27114937
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Learning disorders, Memory Disorders
Pharmacological Actions : Antioxidants
[+]

Fish oil and Nigella sative volatile oil emulsion had promising hepato-regenerative and reno-protective abilities. Feb 18, 2018

Pubmed Data : J Oleo Sci. 2018 Feb 19. Epub 2018 Feb 19. PMID: 29459508
Article Published Date : Feb 18, 2018
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Renoprotective
Additional Keywords : Liver Regeneration
[+]

Garlic extract and Nigella sativa oil are promising agents to complement schistosomiasis specific treatment.Dec 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Rev Inst Med Trop Sao Paulo. 2008 Jan-Feb;50(1):29-36. PMID: 18327484
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Garlic, Nigella sativa (aka Black Seed)
Diseases : Lipid Peroxidation, Schistosomiasis
Pharmacological Actions : Antioxidants, Antiparasitic Agents
Additional Keywords : Plant Extracts
[+]

Grape seed extract, black seed extract and curcumin ameliorate tamoxifen-induced liver injury.Jan 01, 2007

Pubmed Data : Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 21046982
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin, Grape Seed Extract, Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Tamoxifen, Drug-Induced Toxicity
Pharmacological Actions : Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Drug: Tamoxifen, Plant Extracts
[+]

Hexane extracts of N. sativa have a protective and therapeutic role in the oxidative stress, caused by high-fat diets.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Biomed Res. 2018 ;7:121. Epub 2018 Aug 29. PMID: 30211134
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : High Fat Diet, Obesity, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Anti-Obesity Agents
[+]

Hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced oxidative stress.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):86-94. PMID: 27247925
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Turmeric
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Problem Substances : Doxorubicin
[+]

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa.Feb 22, 2018

Pubmed Data : Turk J Med Sci. 2018 Feb 23 ;48(1):178-186. Epub 2018 Feb 23. PMID: 29479981
Article Published Date : Feb 22, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Liver Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Intratympanic nigella sativa oil protects against gentamicin induced hearing loss.May 31, 2017

Pubmed Data : Int J Pediatr Otorhinolaryngol. 2017 Jun ;97:83-88. Epub 2017 Mar 30. PMID: 28483257
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Chemoprotective Agents
[+]

Investigation of the protective effect of Nigella sativa oil in cisplatin induced oral mucositis.Feb 29, 2020

Pubmed Data : Turk Arch Otorhinolaryngol. 2020 Mar ;58(1):10-15. Epub 2019 Sep 2. PMID: 32313889
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oral Mucositis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents
[+]

Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment.Mar 27, 2018

Pubmed Data : Drug Chem Toxicol. 2018 Mar 28:1-10. Epub 2018 Mar 28. PMID: 29589766
Article Published Date : Mar 27, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cognitive Decline/Dysfunction, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor
[+]

Methanolic extracts and volatile oil extracts of N. sativa seed oil may be used as antioxidant as well as hypolipidemic agentsDec 17, 2015

Pubmed Data : Nutrition. 2015 Dec 18. Epub 2015 Dec 18. PMID: 26827238
Article Published Date : Dec 17, 2015
Study Type : Animal Study
Additional Links
Substances : Linoleic acid, Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Hyperlipidemia, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Hypolipidemic
Additional Keywords : Plant Extracts, Plant Oils
[+]

N sativa may protect brain and medulla spinalis tissues against oxidative stress induced by experimental autoimmune encephalomyelitis.Sep 04, 2005

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2005 Sep 5 ;51(3):337-42. Epub 2005 Sep 5. PMID: 16191402
Article Published Date : Sep 04, 2005
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Encephalomyelitis, Multiple Sclerosis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

N. sativa administration exerts potent inhibitory effects on rat tumor development and on cellular proliferation in multiple organ sites.Aug 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2010 Sep ;1(5):913-924. Epub 2010 Sep 1. PMID: 22966405
Article Published Date : Aug 31, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Colon Cancer, Lung Cancer, Stomach Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

N. sativa and propolis could be excellent adjuvant support in the therapy of diabetes mellitus and preventing its complications.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:5439645. Epub 2017 Feb 16. PMID: 28298934
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Nigella sativa (aka Black Seed)
Diseases : Diabetic Complications, Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Renoprotective
[+]

N. sativa and thymoquinone may prove clinically useful in the treatment of diabetics and in the protection of β-cells against oxidative stress.Nov 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Diabetes. 2010 Dec ;2(4):256-66. PMID: 20923501
Article Published Date : Nov 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetes: Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Pancreato Protective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Antioxidants, Diabetes: Oxidative Stress, Nigella sativa (aka Black Seed), Phytotherapy, Plant Extracts, thymoquinone
[+]

N. sativa contains potent bioactive components that may aid in treatment against cisplatin induced renal toxicity.Jul 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ital J Food Saf. 2018 Jul 3 ;2(7):7242. Epub 2018 Jul 3. PMID: 30046560
Article Published Date : Jul 02, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents
[+]

N. sativa could be considered as a potential therapy for asthma therapy and prevention.Oct 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Res Notes. 2018 Oct 19 ;11(1):744. Epub 2018 Oct 19. PMID: 30340634
Article Published Date : Oct 18, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents
[+]

N. sativa could be used in the treatment of rhinosinusitis diseases.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Otorhinolaryngol Ital. 2017 Feb ;37(1):32-37. PMID: 28374868
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Rhinosinusitis
Pharmacological Actions : Nitric Oxide Inhibitor
[+]

N. sativa exerts a protective effect against cadmium toxicity.Nov 30, 2005

Pubmed Data : Biol Trace Elem Res. 2005 Dec ;107(3):277-87. PMID: 16286683
Article Published Date : Nov 30, 2005
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cadmium Poisoning , Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

N. sativa extract and vitamin E improved the serum and urine biochemical parameters and kidney function in cisplatin-induced nephrotoxicity.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):44-54. PMID: 27247921
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Vitamin E
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

N. sativa extract has potential to prevent the hippocampal neural damage after inducing hypothyroidism during neonatal and juvenile growth in rats.May 10, 2017

Pubmed Data : Metab Brain Dis. 2017 May 11. Epub 2017 May 11. PMID: 28497360
Article Published Date : May 10, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypothyroidism
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

N. Sativa extract is effective for early and late prevention of pulmonary fibrosis and inflammation. Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 May-Jun;8(3):263-275. PMID: 29881712
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

N. sativa extract significantly promoted wound healing in diabetic rats.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Prev Med. 2019 ;10:18. Epub 2019 Feb 12. PMID: 30820305
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Wound Healing
[+]

N. sativa may be used to minimize the risk of diabetic microangiopathy.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 May ;12(Suppl 2):S175-80. Epub 2016 May 11. PMID: 27279704
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetic Microangiopathy
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Risk Reduction
[+]

N. sativa may be useful in ameliorating signs of gentamicin nephrotoxicity in rats.Dec 31, 2003

Pubmed Data : Am J Chin Med. 2004 ;32(1):49-55. PMID: 15154284
Article Published Date : Dec 31, 2003
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy
[+]

N. sativa oil is a useful choice for the treatment of anxiety.Mar 31, 2009

Pubmed Data : Pak J Pharm Sci. 2009 Apr ;22(2):139-44. PMID: 19339222
Article Published Date : Mar 31, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents
Additional Keywords : Plant Oils
[+]

N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.Feb 28, 2019

Pubmed Data : Biotech Histochem. 2019 Mar 1:1-9. Epub 2019 Mar 1. PMID: 30821520
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes: Oxidative Stress, Hyperglycemia
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
[+]

N. sativa seed has antidiabetic and antihyperlipidemic properties and improved vasoreactivity, endothelial dysfunction, and vascular inflammation.Jan 09, 2019

Pubmed Data : J Ethnopharmacol. 2019 Jan 10 ;228:142-147. Epub 2018 Sep 14. PMID: 30223051
Article Published Date : Jan 09, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetic Complications, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic
[+]

N. sativa seeds appeared to be safe and possibly protective against carbon tetrachloride induced hepatotoxicity.Dec 31, 2002

Pubmed Data : Am J Chin Med. 2003 ;31(5):721-8. PMID: 14696675
Article Published Date : Dec 31, 2002
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Oils
[+]

N. sativa treatment ameliorated the pentylenetetrazol induced neurodegeneration in the cerebral cortex.Oct 31, 2016

Pubmed Data : Biotech Histochem. 2016 Nov ;91(8):493-500. PMID: 27849392
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Nigella saliva seeds can protect against lead acetate induced hepatic oxidative damage.Mar 02, 2017

Pubmed Data : Biomed Pharmacother. 2017 Mar 3 ;89:711-718. Epub 2017 Mar 3. PMID: 28273633
Article Published Date : Mar 02, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Lead Poisoning, Oxidative Stress
Pharmacological Actions : Hepatoprotective
Problem Substances : Lead
[+]

Nigella sativa stimulate insulin secretion from isolated rat islets and inhibit the digestion and absorption of (CH2O)n in the gut.Aug 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2019 Aug 2. Epub 2019 Aug 2. PMID: 31375555
Article Published Date : Aug 01, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Hypoglycemic Agents, Insulin-releasing
[+]

Nigella sativa (black cumin) and Syzygium aromaticum (clove) protect against aflatoxicosis in rats. May 01, 2005

Pubmed Data : J Appl Toxicol. 2005 May-Jun;25(3):218-23. PMID: 15856529
Article Published Date : May 01, 2005
Study Type : Animal Study
Additional Links
Substances : Clove, Nigella sativa (aka Black Seed)
Diseases : Aflatoxicosis
Pharmacological Actions : Antioxidants
[+]

Nigella sativa (black cumin) protects against chronic antiretroviral therapy-associated insulin resistance in HIV-1 infected rats. Apr 01, 2009

Pubmed Data : Can J Physiol Pharmacol. 2009 Apr;87(4):300-9. PMID: 19370083
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : HIV Drug-Induced Toxicity , Hyperinsulinism
Pharmacological Actions : Antioxidants
Additional Keywords : Drug Side Effect Attenuation
[+]

Nigella sativa acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of gentamicin.Feb 28, 2010

Pubmed Data : Exp Toxicol Pathol. 2010 Mar ;62(2):183-90. Epub 2009 Apr 23. PMID: 19398313
Article Published Date : Feb 28, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy
[+]

Nigella sativa and nettle decrease lipid peroxidation and liver enzymes, and increase the antioxidant defence system activity in CCl4-treated rats.May 31, 2003

Pubmed Data : J Vet Med A Physiol Pathol Clin Med. 2003 Jun ;50(5):264-8. PMID: 14567515
Article Published Date : May 31, 2003
Study Type : Animal Study
Additional Links
Substances : Nettle, Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Oils
[+]

Nigella sativa and onion extract attenuate the pathological effect of nicotine in the lung.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Morphol (Warsz). 2019 ;78(3):554-563. Epub 2018 Dec 21. PMID: 30575005
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Onion
Diseases : Lung Injury: Smoke-Induced, Nicotine/Tobacco Toxicity
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts
[+]

Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats.Apr 22, 2019

Pubmed Data : Metab Brain Dis. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31016464
Article Published Date : Apr 22, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cerebral Hypoperfusion, Dementia
Pharmacological Actions : Neuroprotective Agents
[+]

Nigella sativa and thymoquinone could be a potential treatment against peripheral neuropathy.Dec 31, 2007

Pubmed Data : Neurochem Res. 2008 Jan ;33(1):87-96. Epub 2007 Aug 23. PMID: 17713854
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetic Neuropathy
Pharmacological Actions : Neuroprotective Agents
[+]

Nigella sativa could be efficacious against organophosphate induced oxidative damage.Jun 29, 2018

Pubmed Data : Niger J Physiol Sci. 2018 Jun 30 ;33(1):83-88. Epub 2018 Jun 30. PMID: 30091737
Article Published Date : Jun 29, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Brain: Oxidative Stress, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Dichlorvos, Organophosphates
[+]

Nigella sativa could reduce the chances of hypothyroidism induced gastritis.Mar 09, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Physiol Pathophysiol Pharmacol. 2009 Mar 10 ;1(2):143-149. Epub 2009 Mar 10. PMID: 21383883
Article Published Date : Mar 09, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Gastritis, Hypothyroidism
Pharmacological Actions : Gastroprotective
[+]

Nigella sativa exerts a therapeutic effect on cholestatic liver injury in bile duct ligated rats.Dec 31, 2009

Pubmed Data : Cell Biochem Funct. 2010 Jan ;28(1):83-8. PMID: 20029957
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cholestasis, Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Nigella sativa exerts a therapeutic protective effect in diabetes by decreasing oxidative stress and preserving pancreatic beta-cell integrity.Jun 30, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anat Rec A Discov Mol Cell Evol Biol. 2004 Jul ;279(1):685-91. PMID: 15224410
Article Published Date : Jun 30, 2004
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes: Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Pancreato Protective Agents
Additional Keywords : Plant Extracts
[+]

Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat.Sep 30, 2004

Pubmed Data : J Ethnopharmacol. 2004 Oct ;94(2-3):251-9. PMID: 15325727
Article Published Date : Sep 30, 2004
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hyperlipidemia, Insulin Resistance
Pharmacological Actions : Hypolipidemic, Insulin Sensitizers
Additional Keywords : Plant Extracts
Problem Substances : Insulin
[+]

Nigella sativa extract affects conditioned place preference induced by morphine in rats, indicating it may have therapeutic value in treating morphine dependence and/or tolerance.Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anc Sci Life. 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Morphine Tolerance/Dependence
[+]

Nigella sativa extract has an anti-fatigue activity against exhaustive swimming.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Rep. 2017 Apr ;6(4):468-474. Epub 2017 Feb 24. PMID: 28413647
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fatigue: Excercise-Induced
Therapeutic Actions : Exercise: Swimming
Pharmacological Actions : Antioxidants
[+]

Nigella sativa extract possesses hepatoprotective action against paracetamol induced acute hepatoxicity. Mar 31, 2014

Pubmed Data : Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID: 25911839
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Paracetamol
[+]

Nigella sativa has a protective roll against the initiation of colon carcinogenesis.Sep 30, 2008

Pubmed Data : Phytother Res. 2008 Oct ;22(10):1311-23. PMID: 18570215
Article Published Date : Sep 30, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Selenium, Thymoquinone, Vitamin A
Diseases : Colon Cancer, DNA damage
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Plant Extracts
[+]

Nigella sativa has a significant nephroprotective activity on paracetamol-induced nephrotoxicity.Mar 08, 2016

Pubmed Data : Pharm Biol. 2016 Mar 9:1-10. Epub 2016 Mar 9. PMID: 26956915
Article Published Date : Mar 08, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nigella sativa has protective effect on aspirin-induced nephrotoxicity in rats.Sep 30, 2018

Pubmed Data : J Coll Physicians Surg Pak. 2018 Oct ;28(10):735-738. PMID: 30266114
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Aspirin-Induced Toxicity , Kidney Damage: Drug-Induced
Pharmacological Actions : Renoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Aspirin
[+]

Nigella sativa has protective effects against radiation-induced damage.Feb 16, 2016

Pubmed Data : Pathol Res Pract. 2016 Feb 17. Epub 2016 Feb 17. PMID: 26944830
Article Published Date : Feb 16, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Mucosal Damage: Radiation Induced
Pharmacological Actions : Malondialdehyde Down-regulation, Radioprotective
Anti Therapeutic Actions : Radiotherapy
[+]

Nigella sativa is a potent chemopreventive agent and may suppress potassium bromate-mediated renal oxidative stress, toxicity and tumour promotion.Mar 31, 2003

Pubmed Data : Hum Exp Toxicol. 2003 Apr ;22(4):193-203. PMID: 12755470
Article Published Date : Mar 31, 2003
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Kidney Cancer, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Nigella sativa is a potent chemopreventive agent and suppresses Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis.Mar 31, 2005

Pubmed Data : Eur J Cancer Prev. 2005 Apr ;14(2):159-68. PMID: 15785320
Article Published Date : Mar 31, 2005
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Kidney Cancer, Kidney Cancer: Prevention, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative , Chemopreventive
Additional Keywords : Plant Extracts
[+]

Nigella sativa is protective against methotrexate induced nephrotoxicity.Dec 31, 2016

Pubmed Data : J Intercult Ethnopharmacol. 2017 Jan-Mar;6(1):9-13. Epub 2016 Dec 22. PMID: 28163954
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Chemoprotective Agents, Malondialdehyde Down-regulation, Renoprotective
[+]

Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats.Aug 31, 2000

Pubmed Data : Arzneimittelforschung. 2000 Sep ;50(9):832-6. PMID: 11050701
Article Published Date : Aug 31, 2000
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anticholesteremic Agents, Hepatoprotective
Additional Keywords : Plant Oils
[+]

Nigella sativa L. supplementation greatly improves lead-induced neurotoxicity in early life and provides neuroprotective and antioxidant potentials.Dec 31, 2017

Pubmed Data : Toxicol Res (Camb). 2018 Jan 1 ;7(1):32-40. Epub 2017 Oct 5. PMID: 30090560
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Lead Poisoning, Prenatal Chemical Exposures
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Lead
[+]

Nigella sativa may be a beneficial agent in protection against ionizing radiation-related tissue injury.Oct 31, 2006

Pubmed Data : Photochem Photobiol. 2006 Nov-Dec;82(6):1691-6. PMID: 17387769
Article Published Date : Oct 31, 2006
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
Anti Therapeutic Actions : Low Dose Ionizing Radiation
[+]

Nigella sativa may be clinically useful for protecting beta-cells against oxidative stress.Sep 30, 2009

Pubmed Data : J Mol Histol. 2009 Oct ;40(5-6):379-85. Epub 2010 Jan 5. PMID: 20049514
Article Published Date : Sep 30, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes: Oxidative Stress
Pharmacological Actions : Antioxidants, Pancreato Protective Agents
Additional Keywords : Phytotherapy
[+]

Nigella sativa oil (NSO) and its active component, TQ, clearly protect brain tissue from radiation-induced nitrosative stress.Nov 20, 2013

Pubmed Data : Phytomedicine. 2013 Nov 21. pii: S0944-7113(13)00432-7. doi: 10.1016/j.phymed.2013.10.023. [Epub ahead of print]
Article Published Date : Nov 20, 2013
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cancers: Radiation-Induced, Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
[+]

Nigella sativa oil ameliorates carbon tetrachloride-induced hepatotoxicity.Dec 09, 2019

Pubmed Data : J Food Biochem. 2019 Dec 10:e13108. Epub 2019 Dec 10. PMID: 31823399
Article Published Date : Dec 09, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Nigella sativa oil ameliorates sodium nitrite-induced nephrotoxicity in animals. Jul 28, 2015

Pubmed Data : Redox Rep. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26221999
Article Published Date : Jul 28, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Kidney Fibrosis, Oxidative Stress, Sodium nitrate toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Sodium Nitrate
[+]

Nigella sativa oil and chromium picolinate monotherapy can reduce fructose-induced insulin resistance.Oct 03, 2017

Pubmed Data : Biol Trace Elem Res. 2017 Oct 4. Epub 2017 Oct 4. PMID: 28975521
Article Published Date : Oct 03, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : High Fructose Diet, Hyperinsulinism
Pharmacological Actions : Insulin Sensitizers
[+]

Nigella sativa oil and Thymoquinone correct STZ-diabetes-induced alterations in CK-MB and brain monoamines due to their antioxidant properties.Dec 31, 2008

Pubmed Data : Pharmacology. 2009 ;84(3):127-34. Epub 2009 Aug 13. PMID: 19684436
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetic Neuropathies, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Nigella sativa oil and thymoquinone have protective effects against toxicity induced by the anticancer drug cyclophosphamide.Dec 31, 2009

Pubmed Data : Br J Biomed Sci. 2010 ;67(1):20-8. PMID: 20373678
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Nigella sativa oil and thymoquinone may have protective effects during cerebral ischemia-reperfusion injury.Aug 31, 2007

Pubmed Data : Phytomedicine. 2007 Sep ;14(9):621-7. Epub 2007 Feb 8. PMID: 17291733
Article Published Date : Aug 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cerebral Ischemia, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Phytotherapy
[+]

Nigella sativa oil and thymoquinone maybe useful in amelioration of the intestinal toxicity associated with long-term cisplatin chemotherapy.Jan 03, 2018

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29302711
Article Published Date : Jan 03, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Nigella sativa (aka Black Seed), thymoquinone
[+]

Nigella sativa oil and Thymoquinone reduce oxidative stress in the brain tissue of rats exposed to full head irradiation.Oct 21, 2019

Pubmed Data : Int J Radiat Biol. 2019 Oct 22:1-28. Epub 2019 Oct 22. PMID: 31638880
Article Published Date : Oct 21, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Brain: Oxidative Stress, Radiotherapy
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Radioprotective
[+]

Nigella sativa oil and thymoquinone treatment decreased albuminuria in experimental models of the diabetic nephropathy.May 31, 2016

Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jun ;20(12):2680-8. PMID: 27383323
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Diabetic Nephropathy
Pharmacological Actions : MicroRNA modulator, Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Nigella sativa oil appears to have a therapeutic potential in opioid tolerance and dependence.Sep 30, 2010

Pubmed Data : Neurochem Res. 2010 Oct ;35(10):1557-65. Epub 2010 Jun 15. PMID: 20552271
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Morphine Tolerance/Dependence, Oxidative Stress
Pharmacological Actions : Nitric Oxide Inhibitor
Additional Keywords : Plant Oils
[+]

Nigella sativa oil can protect against Cyclophosphamide-induced DNA damage and hepatotoxicity.Mar 31, 2017

Pubmed Data : Nutr Cancer. 2017 Apr ;69(3):498-504. Epub 2017 Feb 17. PMID: 28287318
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective
[+]

Nigella sativa oil could be a promising agent against moto-cognitive dysfunction and cerebelo-hippocampal alterations induced by cannabis.Aug 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Malays J Med Sci. 2016 Sep ;23(5):17-28. Epub 2016 Oct 5. PMID: 27904421
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabis, Nigella sativa (aka Black Seed)
Diseases : Cognitive Decline/Dysfunction
Additional Keywords : Plant Extracts
[+]

Nigella sativa oil has a possible benefit as disease modifying agents for the insulin resistance in the brain.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(5):e0172429. Epub 2017 May 15. PMID: 28505155
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Nigella sativa oil has a protective effect on the myocardium of streptozotocin-induced diabetes.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):289-294. PMID: 32010345
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetic Complications
Pharmacological Actions : Anti-Apoptotic, Cardioprotective
[+]

Nigella sativa oil imparted a protective action against ethanol induced ulcer in rats.Aug 31, 2000

Pubmed Data : J Ethnopharmacol. 2000 Sep ;72(1-2):299-304. PMID: 10967486
Article Published Date : Aug 31, 2000
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Alcohol Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Gastroprotective
Additional Keywords : Plant Oils
[+]

Nigella sativa oil is a promising natural radioprotective agent against immunosuppressive and oxidative effects of ionizing radiation.May 31, 2010

Pubmed Data : Immunopharmacol Immunotoxicol. 2010 Jun ;32(2):284-96. PMID: 20105084
Article Published Date : May 31, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy and Radiation Toxicity, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Nigella sativa oil may help prevent the accompanying gastrointestinal dysfunction in cisplatin chemotherapy.Feb 14, 2017

Pubmed Data : Exp Toxicol Pathol. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28215571
Article Published Date : Feb 14, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Gastroprotective
Additional Keywords : Chemoprotective Agents, Chemotherapy-Induced Toxicity: Cisplatin, Gastroprotective, Nigella sativa (aka Black Seed)
[+]

Nigella sativa oil may play a role against the alterations caused by S. mansoni infection.Dec 31, 2001

Pubmed Data : J Ethnopharmacol. 2002 Jan ;79(1):1-11. PMID: 11744288
Article Published Date : Dec 31, 2001
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Schistosomiasis
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Oils
[+]

Nigella sativa oil might be beneficial for controlling hypertension.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clinics (Sao Paulo). 2015 Nov ;70(11):751-7. PMID: 26602523
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Heme oxygenase-1 up-regulation
Additional Keywords : Natural Substances Versus Drugs
[+]

Nigella sativa oil protects kidney tissue against oxygen free radicals.Dec 31, 2007

Pubmed Data : Am J Nephrol. 2008 ;28(3):517-22. Epub 2008 Jan 25. PMID: 18223305
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Drug-Induced Toxicity: Cyclosporine
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Nigella sativa oil protects the rat ovary from oxidative injury due to ischemia-reperfusion.Oct 20, 2017

Pubmed Data : Med Sci Monit. 2017 Oct 21 ;23:5027-5033. Epub 2017 Oct 21. PMID: 29055179
Article Published Date : Oct 20, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Ischemia
Pharmacological Actions : Antioxidants
[+]

Nigella sativa oil seems to be a highly promising agent for protecting tissues from oxidative damage and preventing organ damage due to renal I/R.Jun 30, 2008

Pubmed Data : Nephrol Dial Transplant. 2008 Jul ;23(7):2206-12. Epub 2008 Jan 22. PMID: 18211980
Article Published Date : Jun 30, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Malondialdehyde Down-regulation, Renoprotective, Superoxide Dismutase Up-regulation
[+]

Nigella sativa oil significantly attenuated adjuvant-arthritis, and the higher dose prevented the development of arthritis with an inhibition of 56%.Aug 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Aug 25 ;8(9). Epub 2019 Aug 25. PMID: 31450670
Article Published Date : Aug 24, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-6 Downregulation, Prophylactic Agents
Additional Keywords : Risk Reduction
[+]

Nigella sativa oil significantly lowered blood glucose concentrations in diabetic rats.Apr 30, 2002

Pubmed Data : Planta Med. 2002 May ;68(5):465-6. PMID: 12058330
Article Published Date : Apr 30, 2002
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypoglycemia
Pharmacological Actions : Hypoglycemic Agents
Additional Keywords : Plant Oils
[+]

Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.Apr 12, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr 13 ;90:626-637. Epub 2017 Apr 13. PMID: 28412654
Article Published Date : Apr 12, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Nigella sativa oil was found to be the most effective in preventing PTZ-induced seizures relative to valproate.Aug 31, 2005

Pubmed Data : Neuropharmacology. 2005 Sep ;49(4):456-64. PMID: 15913671
Article Published Date : Aug 31, 2005
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Nigella sativa possesses a potential ability to prevent hippocampal neural damage which is accompanied with improving effects on memory.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2016 Jul ;6(3):262-8. Epub 2015 Aug 11. PMID: 27419091
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Seizures
Pharmacological Actions : Neuroprotective Agents
[+]

Nigella sativa Post-conditioning ameliorated cardiac functions in isolated rat heart during I/R injuries by improving myocardial oxidative stress states.Jul 07, 2019

Pubmed Data : Cardiovasc Toxicol. 2019 Jul 8. Epub 2019 Jul 8. PMID: 31286398
Article Published Date : Jul 07, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective
[+]

Nigella sativa provides a therapeutic effect by decreasing the number of fungal colonies and increasing IgM levels.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Glas (Zenica). 2020 Aug 1 ;17(2). Epub 2020 Aug 1. PMID: 32153156
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Candidiasis: Vulvovaginal
Pharmacological Actions : Antifungal Agents
[+]

Nigella Sativa reverses osteoporosis in ovariectomized rats.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2014 ;14(1):22. Epub 2014 Jan 14. PMID: 24422662
Article Published Date : Dec 31, 2013
Study Type : Insect Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Menopausal Syndrome, Osteopenia, Osteoporosis, Ovarian Failure
Additional Keywords : Ovariectomy-Induced Changes
[+]

Nigella sativa seed extract demonstrated incredibly positive effects on enhanced bone healing in this experimental osteoporotic model.Aug 09, 2016

Pubmed Data : J Craniofac Surg. 2016 Aug 10. Epub 2016 Aug 10. PMID: 27513784
Article Published Date : Aug 09, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Osteoporosis
Additional Keywords : Ovariectomy-Induced Changes
[+]

Nigella sativa seed extract has protective effects against acetaminophen induced hepatotoxicity and metabolic disturbances in rats.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID: 26972391
Article Published Date : Feb 29, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
[+]

Nigella sativa seed oil has a protective effect against cisplatin induced acute kidney injury.Dec 04, 2016

Pubmed Data : Biomed Pharmacother. 2016 Dec 5 ;85:7-15. Epub 2016 Dec 5. PMID: 27930989
Article Published Date : Dec 04, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Nigella sativa seeds possess potent anti-inflammatory effects that were not as strong as diclofenac sodium but was more prolonged in effect.Jun 30, 2015

Pubmed Data : J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6. PMID: 26720998
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Diclofenac
[+]

Nigella sativa treatment might be beneficial in lung injury and have potential clinical use.Dec 31, 2008

Pubmed Data : Acta Histochem. 2009 ;111(5):393-403. Epub 2009 May 9. PMID: 19428057
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Nigella sativa treatment might be beneficial in spinal cord tissue damage.Feb 28, 2006

Pubmed Data : Hum Exp Toxicol. 2006 Mar ;25(3):127-33. PMID: 16634331
Article Published Date : Feb 28, 2006
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Lipid Peroxidation, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Nigella Sativa treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury.Jan 31, 2010

Pubmed Data : J Invest Surg. 2010 Feb ;23(1):21-7. PMID: 20233001
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Intestinal Ischemia, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy
[+]

Nigella sativa’s anti-inflammatory and antioxidative effects in experimental inflammation.Sep 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Sep 26 ;9(10). Epub 2020 Sep 26. PMID: 32993150
Article Published Date : Sep 25, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation
[+]

Olive oil and N. sativa oil have a protective effect against carbon tetrachloride induced hepatotoxicity.Nov 03, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Nov 4 ;16(1):438. Epub 2016 Nov 4. PMID: 27814700
Article Published Date : Nov 03, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Olive Oil
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Omega-3 fatty acids, black seed oil and curcuminoids have a therapeutic role in gastritits in an animal model.Oct 01, 2007

Pubmed Data : Eur J Nutr. 2007 Oct;46(7):391-6. Epub 2007 Sep 20. PMID: 18368490
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin, Nigella sativa (aka Black Seed), Omega-3 Fatty Acids
Diseases : Gastritis
Additional Keywords : Plant Extracts
[+]

Oral administration of Nigella sativa oil and thymoquinone attenuates long term cisplatin treatment induced toxicity.Dec 05, 2017

Pubmed Data : Biomed Pharmacother. 2017 Dec 6. Epub 2017 Dec 6. PMID: 29223554
Article Published Date : Dec 05, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Pretreatment with Nigella sativa has a protective effect against renal damage induced by renal reperfusion.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Kidney Dis. 2016 May ;10(3):135-43. PMID: 27225721
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Kidney Damage
Pharmacological Actions : Renoprotective
[+]

Propolis, caffeic acid phenethyl ester, nigella sativa oil and thymoquinone could prevent cataractogenesis in ionizing radiation-induced cataracts in the lenses of rats.Apr 09, 2015

Pubmed Data : Wien Klin Wochenschr. 2015 Apr 10. Epub 2015 Apr 10. PMID: 25860848
Article Published Date : Apr 09, 2015
Study Type : Animal Study
Additional Links
Substances : Bee Propolis, Caffeic acid phenethyl ester, Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cataract: Radiation-Induced
Pharmacological Actions : Radioprotective
Additional Keywords : Plant Extracts
Anti Therapeutic Actions : Low Dose Ionizing Radiation
[+]

Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa.Aug 31, 2010

Pubmed Data : Int J Radiat Biol. 2010 Sep ;86(9):719-31. PMID: 20670109
Article Published Date : Aug 31, 2010
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy and Radiation Toxicity, Lipid Peroxidation
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Radioprotective
Additional Keywords : Plant Extracts
[+]

Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data :
PMID: 23947821
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2
Additional Keywords : Beta Cell Regeneration
[+]

Protective effect of Nigella sativa oil against acetamiprid induced reproductive toxicity in male rats.Jul 02, 2017

Pubmed Data : Drug Chem Toxicol. 2017 Jul 3:1-7. Epub 2017 Jul 3. PMID: 28669218
Article Published Date : Jul 02, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Pesticide Toxicity
Pharmacological Actions : Cytoprotective
Problem Substances : Pesticides
[+]

Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:742-747. Epub 2018 Dec 13. PMID: 30554112
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective
[+]

Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):19-29. PMID: 29456204
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Renoprotective
[+]

Repeated administration of Nigella sativa oil may exert memory enhancing effects against restrained stress.Aug 31, 2017

Pubmed Data : Pak J Pharm Sci. 2017 Sep ;30(5(Supplementary)):2039-2046. PMID: 29105641
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Memory Disorders
Pharmacological Actions : Acetylcholinesterase Inhibitor, Antioxidants, Neuroprotective Agents
[+]

Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity.Dec 16, 2018

Pubmed Data : Hum Exp Toxicol. 2018 Dec 17:960327118818246. Epub 2018 Dec 17. PMID: 30558456
Article Published Date : Dec 16, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Selenium, Thymoquinone
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Renoprotective
Problem Substances : Arsenite
[+]

Synergistic effect of honey and Nigella sativa on wound healing in rats.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Cir Bras. 2018 Jun ;33(6):518-523. PMID: 30020313
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Honey, Nigella sativa (aka Black Seed)
Diseases : Wound Healing
Additional Keywords : Natural Substance Synergy
[+]

The active constituent of black seed, thymoquinone, reversed non-alcoholic fatty liver associated with experimental hypothyroidism in rats.Jan 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Rom J Morphol Embryol. 2019 ;60(2):479-486. PMID: 31658321
Article Published Date : Jan 01, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypothyroidism
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidant, Hepatoprotective
[+]

The combination of nigella sativa oil and pyrimethamine had a synergistic effect in the treatment of toxoplasmosis.Oct 06, 2015

Pubmed Data : Parasitol Res. 2015 Oct 7. Epub 2015 Oct 7. PMID: 26446086
Article Published Date : Oct 06, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Toxoplasma gondii Infection, Toxoplasmosis
Therapeutic Actions : Integrative Medicine
Pharmacological Actions : Antioxidants
Additional Keywords : Natural Substance/Drug Synergy
[+]

The current findings suggested a water soluble extract if Nigella sativa has promising anxiolytic and anti-inflammatory activities.Oct 02, 2019

Pubmed Data : Nat Prod Res. 2019 Oct 3:1-6. Epub 2019 Oct 3. PMID: 31578877
Article Published Date : Oct 02, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Anxiety, Inflammation
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents
[+]

The effect of chronic supplementation of Nigella sativa on splenocytes response in rats following treadmill exercise.May 28, 2019

Pubmed Data : Drug Chem Toxicol. 2019 May 29:1-6. Epub 2019 May 29. PMID: 31137984
Article Published Date : May 28, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fatigue: Excercise-Induced
Therapeutic Actions : Exercise
Pharmacological Actions : Immunomodulatory
[+]

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease.Jul 09, 2019

Pubmed Data : Phytother Res. 2019 Jul 10. Epub 2019 Jul 10. PMID: 31293021
Article Published Date : Jul 09, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cardiovascular Diseases, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
[+]

The essential oil extracted from Nigella sativa seeds produces smooth muscle relaxation.Dec 31, 2015

Pubmed Data : Pak J Pharm Sci. 2016 Jan ;29(1):1-8. PMID: 26826822
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Vasodilator Agents
Additional Keywords : Dose Response, Essential Oils
[+]

The essential oil of black cumin seed has potent analgesic and antiinflammatory activity.Mar 01, 2004

Pubmed Data : Phytother Res. 2004 Mar;18(3):195-9. PMID: 15103664
Article Published Date : Mar 01, 2004
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Pain
Pharmacological Actions : Analgesics: Non-Narcotic, Anti-Inflammatory Agents
[+]

The present study demonstrates that the cytotoxic activity of blackseed extracts is a complex phenomenon.May 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2007 Jun ;40(6):839-47. PMID: 17581684
Article Published Date : May 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative
Additional Keywords : Plant Extracts
[+]

The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide.Feb 05, 2020

Pubmed Data : J Ethnopharmacol. 2020 Feb 6 ;253:112653. Epub 2020 Feb 6. PMID: 32035219
Article Published Date : Feb 05, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

The protective effect of Nigella sativa oil against experimentally induced cisplatin ototoxicity.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Int Adv Otol. 2020 Dec ;16(3):346-352. PMID: 33136014
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents
[+]

The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension.Sep 30, 2018

Pubmed Data : J Basic Clin Physiol Pharmacol. 2018 Oct 1. Epub 2018 Oct 1. PMID: 30269105
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents
[+]

These experimental results strongly indicate the protective effect of Nigella sativa against toxic effect of lead on liver and kidney tissues.Aug 31, 2007

Pubmed Data : Pak J Biol Sci. 2007 Sep 1 ;10(17):2809-16. PMID: 19090181
Article Published Date : Aug 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Lead Poisoning
Pharmacological Actions : Hepatoprotective, Renoprotective
Additional Keywords : Plant Extracts
Problem Substances : Lead
[+]

These finding indicated the probable beneficial role for N. sativa in the treatment of postmenopausal symptoms.Dec 31, 2015

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):95-103. PMID: 27247926
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Menopausal Syndrome, Postmenopausal Disorders
[+]

These findings validate the use of Black seed in gastropathies induced by necrotizing agents. Jun 30, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Gastroenterol. 2008 Jul ;14(3):128-34. PMID: 19568521
Article Published Date : Jun 30, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Drug-Induced Toxicity: Gastrointestinal
Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Gastroprotective
[+]

These results confirm the antidiabetic activity of N. sativa seeds extract.Aug 31, 2006

Pubmed Data : Indian J Exp Biol. 2006 Sep ;44(9):745-8. PMID: 16999030
Article Published Date : Aug 31, 2006
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes: Oxidative Stress, Diabetic Complications, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Plant Extracts
[+]

These results highlight the beneficial role of N. sativa against carbon tetrachloride-induced mutagenicity.Mar 31, 2017

Pubmed Data : Environ Sci Pollut Res Int. 2017 Apr ;24(12):11677-11682. Epub 2017 Mar 21. PMID: 28324259
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Pharmacological Actions : Genoprotective
[+]

These results indicate that Nigella sativa may ameliorate the alteration in the lipid levels caused by diseases or toxic agents.Jun 30, 2009

Pubmed Data : Saudi Med J. 2009 Jul ;30(7):893-6. PMID: 19618002
Article Published Date : Jun 30, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hyperlipidemia
Pharmacological Actions : Hypolipidemic
Additional Keywords : Phytotherapy
[+]

These results suggest that N. sativa oil and thymoquinone produce antinociceptive effects.Jul 13, 2000

Pubmed Data : Eur J Pharmacol. 2000 Jul 14 ;400(1):89-97. PMID: 10913589
Article Published Date : Jul 13, 2000
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Pain
Pharmacological Actions : Antinoceceptive
Additional Keywords : Plant Oils
[+]

These results suggest that Nigella sativa oil has a protective effect against acoustic trauma in early period.Jul 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Audiol Res. 2017 Jul 18 ;7(2):181. Epub 2017 Jul 18. PMID: 28791082
Article Published Date : Jul 17, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hearing Loss: Noise-Induced
[+]

This sheds light on the protective mechanism of Nigella sativa extract against diethylnitrosamine-induced preneoplastic stage of hepatocellular carcinoma.Jun 18, 2018

Pubmed Data : Environ Toxicol. 2018 Jun 19. Epub 2018 Jun 19. PMID: 29923357
Article Published Date : Jun 18, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

This study demonstrated the ameliorative effects of camel milk and Nigella sativa against thioacetamide induced hepatorenal toxicity.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2018 Jan-Mar;14(53):27-35. Epub 2018 Feb 20. PMID: 29576698
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Camel Milk , Nigella sativa (aka Black Seed)
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

This study supports N. sativa use in folk medicine both as analgesic and anti-inflammatory.May 31, 2001

Pubmed Data : J Ethnopharmacol. 2001 Jun ;76(1):45-8. PMID: 11378280
Article Published Date : May 31, 2001
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents
Additional Keywords : Folk Medicine
[+]

Thymoquinone and black cumin seed (Nigella sativa) oil exert a protective effect against breast carcinogens.Mar 15, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Med Sci. 2015 Mar 16 ;11(1):220-9. Epub 2013 Feb 28. PMID: 25861310
Article Published Date : Mar 15, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Breast Cancer: Chemically-Induced
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
Additional Keywords : Plant Extracts
[+]

Thymoquinone and Nigella sativa cause’s morphologic improvement on neurodegeneration in hippocampus after chronic toluene exposure in rats.Feb 29, 2008

Pubmed Data : Neurochem Res. 2008 Mar ;33(3):579-88. Epub 2007 Oct 11. PMID: 17929168
Article Published Date : Feb 29, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Toluene
[+]

Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats.Dec 31, 2003

Pubmed Data : Int J Cardiol. 2004 Jan ;93(1):19-23. PMID: 14729430
Article Published Date : Dec 31, 2003
Study Type : Animal Study
Additional Links
Substances : Methionine, Nigella sativa (aka Black Seed), Thymoquinone
Diseases : High Homocysteine, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Thymoquinone increased the potency of valproate in both PTZ and MES models.Dec 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Health Sci (Qassim). 2008 Jan ;2(1):15-25. PMID: 21475467
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Thymoquinone, a compound derived from black cumin, prevents the development of gentamicin-induced acute renal toxicity in rats.May 01, 2007

Pubmed Data : Clin Exp Pharmacol Physiol. 2007 May-Jun;34(5-6):399-405. PMID: 17439407
Article Published Date : May 01, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Gentamicin, Chemotherapy-Induced Toxicity: Kidney, Kidney Damage, Oxidative Stress
Pharmacological Actions : Renoprotective
[+]

Thymoquinone, an extract of black cumin seed, attenuates arthritis in the rat model of rhematoid.Sep 01, 2007

Pubmed Data : Phytother Res. 2007 Sep;21(9):895-7. PMID: 17562570
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymoquinone, the main constituent of Nigella sativa (black cumin) is superior to the drug fluticasone in an animal model of asthma. Oct 29, 2009

Pubmed Data : J Ethnopharmacol. 2009 Oct 29;126(1):102-7. Epub 2009 Aug 8. PMID: 19711253
Article Published Date : Oct 29, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma
Pharmacological Actions : Anticholinergic, Bronchodilator Agents, Histamine Antagonists
Additional Keywords : Cortisone Alternatives, Drug: Fluticasone, Superiority of Natural Substances versus Drugs
[+]

Thymoquinone-containing Nigella sativa extract based on oral alginate microcapsules could be used for the treatment of inflammatory bowel disease.Feb 28, 2019

Pubmed Data : J Microencapsul. 2019 Mar ;36(2):204-214. Epub 2019 Jun 4. PMID: 31164027
Article Published Date : Feb 28, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Antioxidants
[+]

Topical application of Nigella sativa had beneficial effects on acute radiation-induced nasal mucositis.Jan 18, 2018

Pubmed Data : J Craniofac Surg. 2018 Jan 19. Epub 2018 Jan 19. PMID: 29381633
Article Published Date : Jan 18, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Radiation Induced Illness: Mucositis
Pharmacological Actions : Radioprotective
[+]

Treatment by Nigella sativa reduced myocardial fibrosis in inflammation-induced fibrosis.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2017 Feb ;12(1):74-81. PMID: 28255317
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Anti-Fibrotic, Inflammation, Lipopolysaccharide-Induced Toxicity, Myocardial Fibrosis, Nigella sativa (aka Black Seed)
[+]

Treatment of rats with ethanolic extract of Nigella sativa reduced the number of calcium oxalate deposits.Dec 31, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Urol J. 2007 ;4(2):86-90. PMID: 17701927
Article Published Date : Dec 31, 2006
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Alcohol Toxicity , Kidney Stones
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Virgin olive oil and Nigella sativa seeds had antihyperlipidemic and hypoglycemic effects.Feb 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Morphol (Warsz). 2019 Feb 28. Epub 2019 Feb 28. PMID: 30816553
Article Published Date : Feb 27, 2019
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Olive Oil
Diseases : Hyperlipidemia
Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Pancreato Protective Agents
[+]

Vitamin C and Nigella sativa oil proved to have synergistic nephro-protective effect.Sep 30, 2012

Pubmed Data : Pak J Pharm Sci. 2012 Oct ;25(4):727-30. PMID: 23009987
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Vitamin C
Diseases : Chemotherapy-Induced Toxicity: Gentamicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Additional Keywords : Natural Substance Synergy, Plant Oils
[+]

Whole N. sativa seeds could provide a promising agent effective in both the protection and treatment of experimental autoimmune encephalomyelitis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(6):6269-86. Epub 2015 Jun 1. PMID: 26261504
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Remyelination
[+]

It was also found that heating of NS seeds before oil extraction produces oil that is more effective against cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2015 ;9:3119-24. Epub 2015 Jun 18. PMID: 26124636
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Hodgkin Lymphoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Dose Response
[+]

N. sativa is rich source of different biologically active compounds and is found effective in controlling number of cardiovascular diseases and various cancers both in vivo and in vitro studies. Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2014 Dec ;17(12):967-79. PMID: 25859300
Article Published Date : Nov 30, 2014
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Cancers: All, Cardiovascular Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts
[+]

Potential benefits of combination of Nigella sativa and zinc supplements to treat COVID-19.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Herb Med. 2020 Oct ;23:100382. Epub 2020 Jun 24. PMID: 32834942
Article Published Date : Sep 30, 2020
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Zinc
Diseases : Coronavirus Infection
Pharmacological Actions : Antiviral Agents, Immunomodulatory
[+]

A literature review of the medicinal benefits of Nigella sativa in bronchial asthma.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2017 Dec ;25(8):1130-1136. Epub 2017 Jul 11. PMID: 30166900
Article Published Date : Nov 30, 2017
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma: Bronchial
Pharmacological Actions : Anti-Inflammatory Agents, Histamine down-regulation
[+]

A new oleanane type saponin from the aerial parts of Nigella sativa with anti-oxidant and anti-diabetic potential.May 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 May 6 ;25(9). Epub 2020 May 6. PMID: 32384790
Article Published Date : May 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Hypoglycemic Agents
[+]

A review of dietary plants for the prevention and management of kidney stones.Mar 06, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Mar 7 ;19(3). Epub 2018 Mar 7. PMID: 29518971
Article Published Date : Mar 06, 2018
Study Type : Review
Additional Links
Substances : Green Tea, Hibiscus sabdariffa , Nettle, Nigella sativa (aka Black Seed), Oregano, Parsley, Pomegranate, Raspberry
Diseases : Kidney Stones
[+]

A review of effective medicinal plants in the treatment of the cyclic mastalgia.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2019 Sep ;22(3):131-139. Epub 2019 Sep 30. PMID: 31673442
Article Published Date : Aug 31, 2019
Study Type : Review
Additional Links
Substances : Chaste Tree (Chasteberry), Curcumin, Ginkgo biloba, Nigella sativa (aka Black Seed), St. Johns Wort, Sweet Orange, Wheat Germ
Diseases : Mastalgia
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antioxidants
[+]

A review of herbal therapy in multiple sclerosis.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharm Bull. 2018 Nov ;8(4):575-590. Epub 2018 Nov 29. PMID: 30607330
Article Published Date : Oct 31, 2018
Study Type : Review
Additional Links
Substances : Cannabis, Cranberry, Frankincense, Ginger, Ginkgo biloba, Ginseng, Grape, Kava Kava, Nigella sativa (aka Black Seed), Saffron, St. Johns Wort, Turmeric, Valerian
Diseases : Multiple Sclerosis
[+]

A review of medicinal plants in treatment of hypertriglyceridemia.Sep 04, 2018

Pubmed Data : Phytomedicine. 2018 Sep 5 ;53:43-52. Epub 2018 Sep 5. PMID: 30668411
Article Published Date : Sep 04, 2018
Study Type : Review
Additional Links
Substances : Dill, Garlic, Guggul, Nigella sativa (aka Black Seed), Turmeric
Diseases : Triglycerides: Elevated
Pharmacological Actions : Hypolipidemic
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A review of neuropharmacology effects of nigella sativa and its main component, thymoquinone.May 10, 2016

Pubmed Data : Phytother Res. 2016 May 11. Epub 2016 May 11. PMID: 27169925
Article Published Date : May 10, 2016
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

A review of the effects of Nigella sativa on endothelial dysfunction in diabetes mellitus.Jan 19, 2020

Pubmed Data : J Ethnopharmacol. 2020 Jan 20:112585. Epub 2020 Jan 20. PMID: 31972323
Article Published Date : Jan 19, 2020
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Atherosclerosis, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A review of the health promoting vaules and food applications of black cumin essential oil. Sep 30, 2015

Pubmed Data : J Food Sci Technol. 2015 Oct ;52(10):6136-42. Epub 2015 Mar 27. PMID: 26396361
Article Published Date : Sep 30, 2015
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Bacillus Cereus infection, Bacillus subtilis infections, Gram-Negative Bacterial Infections, Gram-Positive Bacterial Infections, Pseudomonas aeruginosa, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antifungal Agents, Antioxidants
Additional Keywords : Essential Oils
[+]

Alpha-Hederin as an anticancer agent inducing apoptosis in the SKOV-3 cell line.Aug 14, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Aug 15 ;24(16). Epub 2019 Aug 15. PMID: 31443189
Article Published Date : Aug 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Alpha-zam selectively inhibits hepatitis C virus replication.Dec 31, 2015

Pubmed Data : Afr J Tradit Complement Altern Med. 2016 ;13(6):144-148. Epub 2016 Sep 29. PMID: 28480371
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
Additional Keywords : Plant Extracts
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An overview of the analgesic and anti-inflammatory effects of Black Cumin (Nigella sativa) and its active constituent Thymoquinone.Sep 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2015 Sep 14. Epub 2015 Sep 14. PMID: 26366755
Article Published Date : Sep 13, 2015
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Inflammation, Pain
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Antinoceceptive
[+]

An overview of the preclinical pharmacological properties of Nigella sativa.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Physiol Pharmacol. 2016 Dec ;67(6):801-817. PMID: 28195061
Article Published Date : Nov 30, 2016
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma, Cancers: All, Hyperlipidemia, Hypertension, Inflammation, Pain, Ulcers
Pharmacological Actions : Analgesics, Anti-Asthmatic Agents, Anti-Inflammatory Agents, Anti-Ulcer Agents, Anticonvulsants, Antihypertensive Agents, Antimicrobial, Antioxidants, Hypolipidemic, Immunomodulatory
Additional Keywords : Asthma, Cancers: All, hyperlipidemia, hypertension, Inflammation, Nigella sativa (aka Black Seed), pain, Ulcers
[+]

Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line.Jan 12, 2020

Pubmed Data : BMC Complement Med Ther. 2020 Jan 13 ;20(1):5. Epub 2020 Jan 13. PMID: 32020890
Article Published Date : Jan 12, 2020
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
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Bee honey and Nigella sativa are effective in reducing the viability of HepG2 cells.Nov 30, 2012

Pubmed Data : Integr Cancer Ther. 2012 Dec ;11(4):354-63. Epub 2010 Dec 8. PMID: 21147814
Article Published Date : Nov 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Honey, Nigella sativa (aka Black Seed)
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Apoptotic
Additional Keywords : Plant Extracts
[+]

Bioactive compounds of Nigella sativa essential oil as antibacterial agents against Chlamydia Trachomatis D.Sep 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Microorganisms. 2019 Sep 19 ;7(9). Epub 2019 Sep 19. PMID: 31546941
Article Published Date : Sep 18, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chlamydia trachomatis
Pharmacological Actions : Anti-Bacterial Agents
[+]

Black cumin contains a nigellone and thymoquinone which block leukotriene D4 which is associated with respiratory disease. Feb 01, 2008

Pubmed Data : Planta Med. 2008 Feb;74(2):105-8. Epub 2008 Jan 24. PMID: 18219598
Article Published Date : Feb 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Respiratory Diseases
Pharmacological Actions : Antispasmodic, Leukotriene D4 antagonist
[+]

Black cumin reduces leuketriones and 5-lipoxygenase, two inflammatory mediators in asthma.Oct 01, 2004

Pubmed Data : J Enzyme Inhib Med Chem. 2004 Oct;19(5):431-6. PMID: 15648658
Article Published Date : Oct 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma, Asthma: Bronchial
Pharmacological Actions : Leukotriene Antagonists
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Black cumin seeds have probably been used for medicinal purposes since ancient times (3600 years ago). Jul 30, 2009

Pubmed Data : J Ethnopharmacol. 2009 Jul 30;124(3):416-20. Epub 2009 Jun 6. PMID: 19505557
Article Published Date : Jul 30, 2009
Study Type : Commentary
Additional Links
Substances : Nigella sativa (aka Black Seed)
[+]

Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders.Apr 30, 2019

Pubmed Data : Avicenna J Phytomed. 2019 May-Jun;9(3):195-212. PMID: 31143688
Article Published Date : Apr 30, 2019
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Allergies, Cough, Hypersensitivity: Respiratory, Lung Diseases
Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Antitussive Agents
[+]

Comparative immunomodulatory activity of Nigella sativa L. preparations on proinflammatory mediators: a focus on asthma.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1075. Epub 2018 Oct 2. PMID: 30333747
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Alzheimer's Disease, Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
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EGCG and a compound found within black cumin inhibit pancreatic cancer cell proliferation in vitro. Jan 01, 2006

Pubmed Data : Biomed Sci Instrum. 2006;42:363-71. PMID: 16817635
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Nigella sativa (aka Black Seed)
Diseases : Pancreatic Cancer
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EGCG and thymoquinone, a compound found within black cumin, compares to 5-fluorouracil in the suppression of colon cancer cell growth, with a greater safety profile. Jan 01, 2007

Pubmed Data : Biomed Sci Instrum. 2007;43:272-7. PMID: 17487093
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Nigella sativa (aka Black Seed)
Diseases : Colon Cancer
Additional Keywords : Superiority of Natural Substances versus Drugs
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Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species.Mar 31, 2009

Pubmed Data : J Med Food. 2009 Apr ;12(2):408-15. PMID: 19459745
Article Published Date : Mar 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Bacterial Infections, Inflammation
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antifungal Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
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Evaluation of the anticancer activity of sprout extract-loaded nanoemulsion of N. sativa against hepatocellular carcinoma.Jan 22, 2019

Pubmed Data : J Microencapsul. 2019 Jan 23:1-42. Epub 2019 Jan 23. PMID: 30669915
Article Published Date : Jan 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Sprouts
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
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Evaluation of the antioxidant activity of Nigella sativa and Allium ursinum extracts in a cellular model of doxorubicin-induced cardiotoxicity.Nov 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Nov 11 ;25(22). Epub 2020 Nov 11. PMID: 33187371
Article Published Date : Nov 10, 2020
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
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Experimental animal studies showed the protective effect of Nigella sativa or Thymoquinone on chemotherapy-induced nephrotoxicity.Jun 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Jun 17 ;9(6). Epub 2017 Jun 17. PMID: 28629150
Article Published Date : Jun 16, 2017
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Doxorubicin, Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Chemoprotective Agents, Renoprotective
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Experimental evidence suggests that N. sativa extracts and TQ can potentially be effective therapeutic agents towards the regulation of immune reactions.Aug 31, 2015

Pubmed Data : Int Immunopharmacol. 2015 Sep ;28(1):295-304. Epub 2015 Jun 26. PMID: 26117430
Article Published Date : Aug 31, 2015
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Allergies, Autoimmune Diseases, Cancers: All, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory
[+]

Herbal-based nano systems have promising proficiency in treatment of neurodegenerative disorders.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Bioeng Biotechnol. 2020 ;8:238. Epub 2020 Apr 7. PMID: 32318551
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Curcumin, Ginkgo biloba, Nigella sativa (aka Black Seed), Piperine, Quercetin, Resveratrol
Diseases : Alzheimer's Disease, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
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It was observed that Kalonji extracts have ability to induce apoptosis and improve the antioxidant status of HeLa and HepG2 cells.Aug 20, 2019

Pubmed Data : Curr Pharm Biotechnol. 2019 Aug 21. Epub 2019 Aug 21. PMID: 31433749
Article Published Date : Aug 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cervical Cancer,