Phenethyl isothiocyanate

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8 Diseases Researched for Phenethyl isothiocyanate
NameACCKFocus
Prostate Cancer35Locked
Inflammation22Locked
Lung Cancer12Locked
Nicotine/Tobacco Toxicity 12Locked
Smoking12Locked
Lipopolysaccharide-Induced Toxicity11Locked
Ovarian Cancer11Locked
Oxidative Stress11Locked
13 Pharmacological Actions Researched for Phenethyl isothiocyanate
NameACCKFocus
Anticarcinogenic Agents58Locked
Antiproliferative 35Locked
Apoptotic35Locked
Antineoplastic Agents23Locked
Anti-Inflammatory Agents11Locked
Anti-metastatic11Locked
Antioxidants11Locked
Chemopreventive11Locked
Cyclooxygenase 2 Inhibitors11Locked
MicroRNA modulator11Locked
NF-kappaB Inhibitor11Locked
Nrf2 activation11Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor11Locked
Related Topics

Phenethyl isothiocyanate is a Sub of the following Topic

View the Evidence:
38 Abstracts with Phenethyl isothiocyanate Research

[+]

Curcumin and phenethyl isothiocyanate have a synergistic inhibitory effect on the growth of human prostate xenografts. Jul 01, 2008

Pubmed Data : Am J Clin Nutr. 2008 Jul;88(1):216-23. PMID: 16423986
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Curcumin and phenyethylisothiocyanate inhibite mouse prostate cancer. Sep 01, 2008

Pubmed Data : Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 18437538
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.Sep 15, 2005

Pubmed Data : Cancer Res. 2005 Sep 15;65(18):8548-57. PMID: 16166336
Article Published Date : Sep 15, 2005
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine), Phenethyl isothiocyanate, Sulforaphane
Diseases : Lung Cancer, Nicotine/Tobacco Toxicity , Smoking
Pharmacological Actions : Anticarcinogenic Agents
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate hampers growth and progression of HER2-positive breast and ovarian carcinoma by targeting their stem cell compartment.Aug 01, 2019

Pubmed Data : Cell Oncol (Dordr). 2019 Aug 2. Epub 2019 Aug 2. PMID: 31376137
Article Published Date : Aug 01, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Breast Cancer, Ovarian Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells, Natural Substance/Drug Synergy
[+]

Phenethyl isothiocyanate inhibits in vivo growth of xenograft tumors of human glioblastoma cells.Sep 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 10 ;23(9). Epub 2018 Sep 10. PMID: 30201893
Article Published Date : Sep 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative
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Phenethyl isothiocyanate may act as a promising anticancer agent either alone or in combination with doxorubicin through apoptotic cell death induction.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2018 ;17(4):1328-1338. PMID: 30568691
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Ehrlich carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
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Phenethyl isothiocyanate treatment suppressed the proliferation of ALDH1 expressing cancer stem cells.Feb 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 27 ;20(5). Epub 2019 Feb 27. PMID: 30818757
Article Published Date : Feb 26, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
[+]

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth.Jan 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Differ. 2016 10 ;23(10):1615-27. Epub 2016 Jun 3. PMID: 27258787
Article Published Date : Jan 09, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Tumor Suppressor Protein p53 Upregulation
[+]

These findings indicate that benzyl isothiocyanate and phenethyl isothiocyanate ameliorate high fat diet-induced obesity and fatty liver.Jun 25, 2019

Pubmed Data : J Agric Food Chem. 2019 Jun 26 ;67(25):7136-7146. Epub 2019 Jun 18. PMID: 31240929
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Fatty Liver, Obesity
Pharmacological Actions : Hepatoprotective
Additional Keywords : Anti-Obesity Agents
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A combination of phenethyl isothiocyanate and TH588 has potential as a novel therapeutic strategy against pancreatic cancer.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Mar ;15(3):3240-3244. Epub 2017 Dec 29. PMID: 29435064
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic
[+]

A review of the role of phytochemicals in cancer prevention.Oct 08, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 9 ;20(20). Epub 2019 Oct 9. PMID: 31600949
Article Published Date : Oct 08, 2019
Study Type : Review
Additional Links
Substances : Benzyl isothiocyanate , Capsaicin, Catechin , Cucurbitacin B , Isoflavones, Lycopene, Phenethyl isothiocyanate, Piperlongumine
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents
[+]

Anti-rheumatic activity of phenethyl isothiocyanate via inhibition of histone deacetylase-1.May 31, 2020

Pubmed Data : Chem Biol Interact. 2020 Jun 1 ;324:109095. Epub 2020 Apr 11. PMID: 32289289
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):832-840. Epub 2017 Jul 27. PMID: 28766686
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Isothiocyanates
[+]

benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. Jun 30, 2016

Pubmed Data : Vojnosanit Pregl. 2016 Jul ;73(7):636-42. PMID: 29314795
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive
Additional Keywords : Isothiocyanates
[+]

Beta-phenylethyl isothiocyanate and curcumin work synergistically to inhibit prostate cancer cell signaling.Aug 01, 2006

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1526-31. PMID: 16299382
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells.Feb 14, 2020

Pubmed Data : Toxicol In Vitro. 2020 Feb 15:104799. Epub 2020 Feb 15. PMID: 32070777
Article Published Date : Feb 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate, Xanthohumol
Diseases : Pancreatic Cancer
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Natural Substance Synergy
[+]

Glucosinolate-degradation products as co-adjuvant therapy on prostate cancer in vitro.Oct 08, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Oct 9 ;20(20). Epub 2019 Oct 9. PMID: 31600887
Article Published Date : Oct 08, 2019
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol, Isothiocyanates, Phenethyl isothiocyanate, Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Docetaxel
[+]

In this review, we summarize the cancer chemopreventive role of naturally occurring glucosinolate derivatives as inhibitors of carcinogenesis.Apr 30, 2015

Pubmed Data : Curr Pharmacol Rep. 2015 May ;1(3):179-196. Epub 2015 Jan 30. PMID: 26457242
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Indole-3-Carbinol, Phenethyl isothiocyanate, Sulforaphane
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive, MicroRNA modulator, Nrf2 activation
Additional Keywords : DNA Methylation
[+]

Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate in lung cancer cells.Dec 25, 2017

Pubmed Data : Mol Carcinog. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29278657
Article Published Date : Dec 25, 2017
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Autophagy Up-regulation
[+]

Inhibition of glycolysis in prostate cancer chemoprevention by phenethyl isothiocyanate.Mar 14, 2018

Pubmed Data : Cancer Prev Res (Phila). 2018 Mar 15. Epub 2018 Mar 15. PMID: 29545400
Article Published Date : Mar 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive
[+]

Isothiocyanates suppress the invasion and metastasis of tumors.Sep 07, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Sep 8 ;8(38):63949-63962. Epub 2017 Jul 12. PMID: 28969043
Article Published Date : Sep 07, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Molecular mechanisms of the anti-cancer effects of isothiocyanates from cruciferous vegetables in bladder cancer.Jan 28, 2020

Pubmed Data : Molecules. 2020 Jan 29 ;25(3). Epub 2020 Jan 29. PMID: 32013065
Article Published Date : Jan 28, 2020
Study Type : Review
Additional Links
Substances : Benzyl isothiocyanate , Cruciferous Vegetables, Isothiocyanates, Phenethyl isothiocyanate, Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Chemopreventive
[+]

Phenethyl isothiocyanate activates leptin signaling and decreases food intake.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0206748. Epub 2018 Nov 1. PMID: 30383868
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Obesity
Pharmacological Actions : Appetite Suppresant
Additional Keywords : Anti-Obesity Agents
[+]

Phenethyl isothiocyanate and Benzyl isothiocyanate inhibit human melanoma A375.S2 cell migration and invasion.Jan 10, 2017

Pubmed Data : Anticancer Res. 2017 11 ;37(11):6223-6234. PMID: 29061805
Article Published Date : Jan 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate , Phenethyl isothiocyanate
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Anti-metastatic
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate and cisplatin co-encapsulated in a liposomal nanoparticle for treatment of non-small cell lung cancer.Feb 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Feb 22 ;24(4). Epub 2019 Feb 22. PMID: 30813352
Article Published Date : Feb 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane have a synergistic effect in the inhibition of inflammation.Jan 01, 2009

Pubmed Data : Pharm Res. 2009 Jan;26(1):224-31. Epub 2008 Oct 8. PMID: 18841446
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Phenethyl isothiocyanate, Sulforaphane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Isothiocyanates, Natural Substance Synergy
[+]

Phenethyl isothiocyanate and ursolic acid protects DNA from oxidative damage.Jan 29, 2018

Pubmed Data : Mol Nutr Food Res. 2018 Jan 30. Epub 2018 Jan 30. PMID: 29383876
Article Published Date : Jan 29, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : DNA damage
Pharmacological Actions : Genoprotective
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Phenethyl isothiocyanate has promising anti-osteosarcoma activity.Mar 03, 2020

Pubmed Data : Acta Pharmacol Sin. 2020 Mar 4. Epub 2020 Mar 4. PMID: 32132657
Article Published Date : Mar 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Phenethyl isothiocyanate in combination with dibenzoylmethane inhibits the androgen-independent growth of prostate cancer cells.Apr 24, 2018

Pubmed Data : Food Funct. 2018 Apr 25 ;9(4):2398-2408. PMID: 29595853
Article Published Date : Apr 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Dibenzoylmethane (DBM), Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor, Survivin Down-Regulation
[+]

Phenethyl isothiocyanate induces apoptotic cell death in gefitinib-resistant NCI-H460 human lung cancer cells.Dec 31, 2017

Pubmed Data : Anticancer Res. 2018 04 ;38(4):2137-2147. PMID: 29599332
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: Drug Resistant, Lung Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Isothiocyanates
[+]

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.Nov 30, 2018

Pubmed Data : Phytother Res. 2018 Dec ;32(12):2447-2455. Epub 2018 Aug 30. PMID: 30159926
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Wnt/β-catenin signaling pathway modulation
Additional Keywords : Cancer Stem Cells
[+]

Phenethyl isothiocyanate suppresses stemness in the chemo- and radio-resistant triple-negative breast cancer cells.Jan 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2020 Jan 22 ;12(2). Epub 2020 Jan 22. PMID: 31979093
Article Published Date : Jan 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
Additional Keywords : Cancer Stem Cells
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Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer.Dec 15, 2016

Pubmed Data : Cancer Biol Ther. 2016 Dec 16:1-10. Epub 2016 Dec 16. PMID: 27981892
Article Published Date : Dec 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Phenethyl isothiocyanate
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-metastatic
[+]

Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non-small cell lung cancer cells.Mar 17, 2020

Pubmed Data : Mol Carcinog. 2020 Mar 18. Epub 2020 Mar 18. PMID: 32189414
Article Published Date : Mar 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Sequential treatment of phenethyl isothiocyanate increases sensitivity of Temozolomide resistant glioblastoma cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(2):696-708. Epub 2019 Feb 15. PMID: 30899372
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cancers: Drug Resistant, Glioblastoma
Pharmacological Actions : Antiproliferative , Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells.Apr 16, 2018

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2018 Apr 17. Epub 2018 Apr 17. PMID: 29666895
Article Published Date : Apr 16, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Cholangiocarcinoma
Pharmacological Actions : Cytotoxic
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This enhances the understanding of the potential cancer preventive and treatment effects of isothiocyanate compounds prostate cancer.Oct 31, 2018

Pubmed Data : Anticancer Res. 2018 Nov ;38(11):6069-6083. PMID: 30396921
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Prostate Cancer
Pharmacological Actions : Chemopreventive, Chemotherapeutic
[+]

β-phenethyl isothiocyanate induces cell death in human osteosarcoma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:5021983. Epub 2020 Apr 4. PMID: 32322335
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic

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