Polyphenols

Name	AC	CK
Cardiovascular Diseases	32	178
Oxidative Stress	61	143
Hypertension	16	117
Obesity	17	70
Endothelial Dysfunction	10	66
Cholesterol: Oxidation	9	65
Inflammation	21	59
Insulin Resistance	6	44
Prostate Cancer	14	43
HDL: Low	4	40
Diabetes Mellitus: Type 2	9	38
Metabolic Diseases	6	35
Arteriosclerosis	6	34
Breast Cancer	25	33
Cancers: All	26	32
DNA damage	13	27
Lipid Peroxidation	10	26
High Cholesterol	5	25
Lipopolysaccharide-Induced Toxicity	9	24
Diarrhea	3	22
Radiation Induced Illness	8	22
Alzheimer's Disease	16	21
Dysbiosis	3	21
Dysbiosis: Bifidobacteria Deficiency	3	21
HIV Infections	3	21
All-Cause Mortality	2	20
Cholesterol: LDL/HDL ratio	2	20
Hemodialysis	1	20
Prostate: PSA Doubling	2	20
Atherosclerosis	7	19
Cognitive Decline/Dysfunction	5	18
Colon Cancer	13	17
Diabetes Mellitus: Type 2: Prevention	3	17
Neurodegenerative Diseases	13	16
Nonalcoholic fatty liver disease (NAFLD)	5	16
Aging	9	15
Chemically-Induced Liver Damage	8	15
Dementia	5	14
Hyperglycemia	4	14
Liver Cancer	4	14
Escherichia coli Infections	3	13
Hyperlipidemia	7	13
Triglycerides: Elevated	3	13
Dental Caries	3	12
Gallbladder Cancer	2	12
Cardiovascular Disease: Prevention	2	11
Helicobacter Pylori Infection	2	11
Human T-Cell Lymphotrophic Virus type 1 associated disease	2	11
Prostate Cancer: Prevention	2	11
AIDS	1	10
Adult T-cell leukemia/lymphoma (ATL)	1	10
Aflatoxicosis	1	10
Angina Pectoris	1	10
Arterial Thickening	1	10
Bile Duct Cancer	1	10
Blood Pressure: High	1	10
C-Reactive Protein	1	10
Carotid Artery Narrowing	1	10
Common Cold	1	10
Constipation	1	10
Diabetes: Cardiovascular Illness	1	10
Diarrhea: in Children	1	10
Fibromyalgia	1	10
Gastroenteritis	1	10
Heart Disease: Ischemic	1	10
Intima Media Thickening	1	10
Libido: Low	1	10
Lung Cancer: Prevention	1	10
Muscle Damage: Exercise-Induced	1	10
Myocardial Infarction	5	10
Neurofibromatosis	1	10
Obesity: Abdominal	1	10
Overweight	1	10
Pulmonary Diseases	1	10
Rotavirus Infections	1	10
Sexaul Dysfunction	1	10
Smoking	1	10
Systemic Lupus Erythematosus	1	10
Alcohol Toxicity	4	8
Alcoholic Liver Disease	4	8
Breast Cancer: Metastatic	4	8
Breast Cancer: Triple Negative	6	8
Cadmium Poisoning	4	8
High Fat Diet	4	8
Metabolic Syndrome X	5	8
Parkinson's Disease	7	8
Sepsis	3	8
Ultraviolet Radiation Induced Damage	3	8
Colorectal Cancer	3	7
Lung Cancer	5	7
Colitis	3	6
Colorectal Cancer: Prevention	2	6
Diabetic Complications	4	6
Diabetic Nephropathy	3	6
Endotoxemia	3	6
Fatty Liver	3	6
Immune Disorders: Low Immune Function	3	6
Pancreatic Cancer	4	6
Allergies	3	5
Anti-gliadin Antibodies: Elevated	1	5
Brain Inflammation	4	5
Cancers: Drug Resistant	4	5
Cervical Cancer	5	5
Depression	4	5
Food Allergies: Wheat	1	5
Kidney Damage: Chemically-Induced	3	5
Liver Damage	3	5
Melanoma	4	5
Aging Skin	3	4
Aging: Brain	2	4
Aluminum Toxicity	2	4
Breast Cancer: Lung Metastasis	2	4
Colon Cancer: Prevention	3	4
Gastric Ulcer	2	4
Hypercholesterolemia	2	4
Hyperuricemia	2	4
Irritable Bowel Syndrome	2	4
Oral Cancer	4	4
Advanced Glycation End products (AGE)	2	3
Cancer Metastasis	2	3
Cholera	2	3
High Homocysteine	2	3
Inflammatory Bowel Diseases	2	3
Influenza	2	3
MRSA	2	3
Periodontitis	2	3
Pseudomonas aeruginosa	3	3
Snake Bite: Venom Toxicity	2	3
Staphylococcus aureus infection	3	3
Acute lymphoblastic leukemia (ALL)	2	2
Aging: Immunosenecence	1	2
Alopecia	1	2
Amyotrophic Lateral Sclerosis	2	2
Anaphylaxis	1	2
Aneurysm: Aortic	1	2
Antibiotic Toxicity	1	2
Arsenic Poisoning	2	2
Autoimmune Diseases	1	2
Brain Injury: Hippocampal Damage	1	2
Cancers: Radiation-Resistant	1	2
Cardiac Hypertrophy	1	2
Cerebral Ischemia	1	2
Chemical Exposure: Nitrobenzene	1	2
Chemotherapy-Induced Toxicity: Cisplatin	1	2
Chemotherapy-Induced Toxicity: Irinotecan	1	2
Clostridium Infections	2	2
Dermatitis	1	2
Diabetes: Cognitive Dysfunction	1	2
Diesel Exhaust Particle Toxicity	1	2
Dioxin Toxicity	1	2
Drug-Induced Toxicity: Cyclosporine	1	2
Dyslipidemias	1	2
Esophageal Cancer	2	2
Food Allergies	1	2
Fructose-Induced Toxicity	1	2
Giardiasis	2	2
Glaucoma	2	2
Hair Loss	1	2
Hashimoto's thyroiditis	1	2
Heavy Metal Toxicity	1	2
High Fructose Diet	1	2
Hypersensitivity	1	2
Hypertension: Arterial	1	2
Hypothyroidism	1	2
IgA Deficiency	1	2
IgE-Mediated Hypersensitivity	1	2
Infertility: Aging Associated	1	2
Infertility: Female	1	2
Intestinal Diseases	1	2
Liver Damage: Aflatoxin-Induced	1	2
Liver Fibrosis	1	2
Low Immune Function: Thymus Dysfunction	1	2
Lung Injury: Acute	1	2
Lymphoma	1	2
Melanoma: Metastatic	1	2
Memory Disorders	1	2
Mycobacterium tuberculosis	2	2
Myocarditis: Autoimmune	1	2
Neuroblastoma	2	2
Osteoporosis	1	2
Ovariectomy Associated Adverse Changes	1	2
Periodontal Diseases	2	2
Petroleum Exposure And Toxicity	1	2
Prostatic Hyperplasia: Benign	1	2
Psychiatric Disorders	2	2
Radiation Induced Illness: Bone Marrow	1	2
Retinal Degeneration: Light-Induced	2	2
Schizophrenia	2	2
Skin Diseases: Photo-Aging	2	2
Steptococcus Mutans Infections	2	2
Stress	1	2
Tetanus	1	2
Tumors	1	2
Ulcerative Colitis	1	2
Vaccine-induced Toxicity	1	2
Acrylamide-induced toxicity	1	1
Air Pollution Linked Toxicity	1	1
Asbestos Toxicity	1	1
Attention Deficit Disorder	1	1
Attention Deficit Hyperactivity Disorder	1	1
Autism Spectrum Disorders	1	1
Barrett Esophagus	1	1
Benzene Toxicity	1	1
Bladder Cancer	1	1
Bladder Cancer: Prevention	1	1
Brain: Microglial Activation	1	1
Breast Cancer: HER-2 Overexpressed	1	1
Cancers	1	1
Cancers: Multi-Drug Resistant	1	1
Candida Albicans	1	1
Candida Infection	1	1
Carcinoma: Non-Small-Cell Lung	1	1
Cataract	1	1
Chlamydia Infections	1	1
Chronic Obstructive Pulmonary Disease	1	1
Clotting	1	1
Coronary Artery Disease	1	1
Cryptosporidiosis	1	1
Diabetes	1	1
Diabetes Mellitus: Type 1	1	1
Diabetic Retinopathy	1	1
Ebola Virus Infections	1	1
Erectile Dysfunction	1	1
Excitotoxicity	1	1
Eye Damage	1	1
Eye Diseases	1	1
Foodborne Pathogens: Prevention/Food Preservation	1	1
Fusobacterium Infections	1	1
Gastric Cancer	1	1
Glioblastoma	1	1
Glioma	1	1
H3N2 Infection	1	1
H5N1 Infection	1	1
Hepatoma	1	1
Herpes Simplex Virus Type 2	1	1
Human Papillomavirus (HPV)	1	1
Hyperpigmentation	1	1
Hypoglycemia	1	1
Infertility	1	1
Influenza A	1	1
Iron Overload	1	1
Kidney Damage: Drug-Induced	1	1
Leukemia: Chronic Lymphocytic Leukemia (CLL)	1	1
Macular Degeneration	1	1
Malaria	1	1
Malignant Melanoma	1	1
Mesothelioma	1	1
Multiple Sclerosis	1	1
Neurologic Disorders	1	1
Ovarian Cancer	1	1
Pesticide Toxicity	1	1
Promyelocytic leukemia	1	1
Protozoan Infections	1	1
Psoriasis	1	1
Sarcopenia	1	1
Skin Cancer	1	1
Staphylococcal Infections	1	1
Sugar (Sucrose) Toxicity	1	1
Tertiary butyl hydroperoxide toxicity	1	1
Thrombosis	1	1
Vibrio Infections	1	1

Name	AC	CK
Antioxidants	152	387
Anti-Inflammatory Agents	69	144
Antihypertensive Agents	15	108
Cardioprotective	21	77
Chemopreventive	35	73
Antiproliferative	49	69
Neuroprotective Agents	29	59
Tumor Necrosis Factor (TNF) Alpha Inhibitor	26	53
Hypolipidemic	11	52
Gastrointestinal Agents	11	51
Apoptotic	41	48
Anticholesteremic Agents	7	45
NF-kappaB Inhibitor	19	44
Hepatoprotective	23	42
Anticarcinogenic Agents	17	35
Interleukin-6 Downregulation	19	32
Cell cycle arrest	18	27
Interleukin-1 beta downregulation	16	27
MicroRNA modulator	12	26
Anti-Bacterial Agents	15	25
Immunomodulatory	10	25
Radioprotective	9	24
Superoxide Dismutase Up-regulation	5	24
Vasodilator Agents	3	24
Hypoglycemic Agents	9	22
Anti-metastatic	15	20
Insulin Sensitizers	2	20
Anti-Apoptotic	7	19
Cyclooxygenase 2 Inhibitors	10	17
Antiviral Agents	6	16
Anti-atherogenic	3	14
Antineoplastic Agents	11	13
Antidiarrheals	2	12
Cytoprotective	6	12
Nitric Oxide Enhancer	2	11
Renoprotective	6	11
Anti-Allergic Agents	4	10
Hepatocyte growth factor (HGF) inhibitor	1	10
Vascular Endothelial Growth Factor Regulator	1	10
Enzyme Inhibitors	7	9
Matrix metalloproteinase-2 (MMP-2) inhibitor	5	9
Photoprotective	4	9
Nrf2 activation	5	8
Vascular Endothelial Growth Factor Inhibitors	3	8
Genoprotective	5	7
Angiogenesis Inhibitors	2	6
Anti Inflammatory	2	6
Chemotherapeutic	4	6
Malondialdehyde Down-regulation	3	6
Chemoprotective Agents	3	5
Glucagon Like peptide 1 (GLP-1) Up-regulation	1	5
Matrix metalloproteinase-9 (MMP-9) inhibitor	3	5
Alpha-glucosidase inhibitor	3	4
Anti-Ulcer Agents	2	4
Cyclooxygenase Inhibitors	2	4
Interleukin-10 downregulation	2	4
Anti-Angiogenic	3	3
Anti-Glycation Agents	2	3
Anti-Tumor	2	3
Antidepressive Agents	2	3
Antimicrobial	3	3
Epidermal growth factor receptor (EGFR) inhibitor	2	3
Gastroprotective	2	3
Interleukin-8 downregulation	3	3
Nitric Oxide Inhibitor	2	3
Prophylactic Agents	2	3
Quorum Sensing Inhibition	3	3
Radiosensitizer	2	3
Regenerative	2	3
Tumor Suppressor Protein p53 Upregulation	3	3
Acetylcholinesterase Inhibitor	2	2
Antimutagenic Agents	2	2
Autophagy Inhibitors	1	2
Bax/Bcl2 Ratio: Decrease	1	2
Bcl-2 protein down-regulation	1	2
Bone Density Conservation Agents	1	2
Caspase-3 Activation	1	2
Chelating Agents	1	2
Chemosensitizer	2	2
Dermatologic Agents	1	2
Gluconeogenesis Inhibitor	2	2
Heme oxygenase-1 up-regulation	1	2
Histone deacetylase inhibitor	2	2
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor	2	2
Interleukin-18 down-regulation	1	2
Interleukin-2 Downregulation	1	2
Interleukin-4 downregulation	1	2
Interleukin-5 downregulation	1	2
Matrix Metalloproteinases Inhibitors	1	2
Matrix metalloproteinase-1 (MMP-1) inhibitor	1	2
Phase II Detoxification Enzyme Inducer	1	2
Proteasome Inhibitors	2	2
STAT3 Inhibitor	2	2
Vascular Cell Adhesion Molecule-1 Inhibitor	2	2
angiogenesis	1	2
interleukin-13 down-regulation	1	2
AMP-activated protein kinase modulation	1	1
Adiponectin upregulation	1	1
Alpha-amylase inhibitor	1	1
Anti-Infective Agents	1	1
Anti-Platelet	1	1
Anticoagulants	1	1
Antifungal Agents	1	1
Antiprotozoal Agents	1	1
DNA Repair Up-regulation	1	1
E-cadherin down-regulation	1	1
Fertility Agents	1	1
Forkhead Transcription Factor Family O (FOXO) Modulator	1	1
Glucose Uptake Optimization	1	1
Glutathione Upregulation	1	1
Insulin-releasing	1	1
Interleukin-1 alpha downregulation	1	1
Leukotriene Antagonists	1	1
Matrix metalloproteinase-14 (MMP-14) inhibitor	1	1
Matrix metalloproteinase-16 (MMP-16) inhibitor	1	1
Matrix metalloproteinase-17 (MMP-17) inhibitor	1	1
Matrix metalloproteinase-8 (MMP-8) inhibitor	1	1
NF-E2-Related Factor-2 (Nrf2) Modulator	1	1
Neuritogenic	1	1
Neurominidase Inhibitor	1	1
P21 Activation	1	1
Topoisomerase II Inhibitor	1	1
Tumor Suppressor Protein p73 Upregulation	1	1
Tyrosinase inhibitors	1	1
Vascular Endothelial Growth Factor A Inhibitor	1	1
Wnt/β-catenin signaling pathway modulation	1	1

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Physiol Rep. 2018 Jan ;6(2). PMID: 29380956

Article Published Date : Dec 31, 2017

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Pubmed Data : Eur J Clin Nutr. 2015 Jun 10. Epub 2015 Jun 10. PMID: 26059745

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Pubmed Data : Neurology. 2018 May 29 ;90(22):e1979-e1988. Epub 2018 Apr 27. PMID: 29703769

Article Published Date : May 28, 2018

Study Type : Human Study

Additional Links

Substances : Berries: All, Nuts, Olive Oil, Polyphenols, Red Wine Extract, Vegetables: All

Diseases : Dementia

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

A polyphenol-rich beverage reduces symptoms associated with the common cold.Oct 01, 2010

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Pubmed Data : Br J Nutr. 2010 Oct;104(8):1156-64. Epub 2010 May 21. PMID: 20487584

Article Published Date : Oct 01, 2010

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Common Cold

[+]

A polyphenol-rich whole food supplement significantly effected the rate of PSA progression among men with prostate cancer.Mar 10, 2014

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Pubmed Data : J Agric Food Chem. 2009 Sep 9;57(17):7743-9. PMID: 19691323

Article Published Date : Sep 09, 2009

Study Type : Human Study

Additional Links

Substances : Apples, Flavonoids, Polyphenols

Diseases : Helicobacter Pylori Infection

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterolDec 31, 2016

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Pubmed Data : Nutr Res. 2017 Jan ;37:67-77. Epub 2016 Dec 10. PMID: 28215316

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Anthocyanins, Chokeberry, Polyphenols

Diseases : Cardiovascular Diseases, Hypertension, Inflammation, Oxidative Stress

Pharmacological Actions : Hypolipidemic

Additional Keywords : Plant Extracts

[+]

Bilberry has anti-inflammatory properties.Sep 01, 2010

Pubmed Data : Int J Food Sci Nutr. 2015 May ;66(3):350-4. Epub 2015 Feb 10. PMID: 25666414

Article Published Date : May 01, 2015

Study Type : Human Study

Additional Links

Substances : Coffee, Polyphenols

Diseases : Endothelial Dysfunction

[+]

Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function.Aug 31, 2017

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Pubmed Data : Biosci Biotechnol Biochem. 2017 Sep ;81(9):1814-1822. Epub 2017 Jul 4. PMID: 28675091

Article Published Date : Aug 31, 2017

Study Type : Human Study

Additional Links

Substances : Coffee, Coffee: Green/Unroasted, Polyphenols

[+]

Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects.Apr 29, 2015

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Pubmed Data : Nutrients. 2015 Apr 30 ;7(5):3138-53. Epub 2015 Apr 30. PMID: 25942487

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Pubmed Data : Nutrients. 2018 Nov 20 ;10(11). Epub 2018 Nov 20. PMID: 30463296

Article Published Date : Nov 19, 2018

Study Type : Human Study

Additional Links

Substances : Fruit: All, Polyphenols, Vegetables: All

Diseases : Sleep Disorders

[+]

Gazpacho soup consumption is associated with a lower prevalence of hypertension.Sep 30, 2013

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2013 Oct ;23(10):944-52. Epub 2012 Nov 11. PMID: 23149074

Problem Substances : Tobacco: Smoking

[+]

Green tea drinking suppresses proliferation of HTLV-1-infected lymphocytes in vivo.Jul 01, 2004

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Pubmed Data : Cancer Sci. 2004 Jul;95(7):596-601. PMID: 15245597

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : Green Tea, Polyphenols

Diseases : Adult T-cell leukemia/lymphoma (ATL) , Human T-Cell Lymphotrophic Virus type 1 associated disease

Pharmacological Actions : Antiviral Agents

[+]

Green tea extract decreased fasting insulin concentrations in those with elevated baseline fasting concentrations.Jan 01, 2016

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Pubmed Data : J Nutr. 2016 Jan ;146(1):38-45. Epub 2015 Nov 18. PMID: 26581683

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Pubmed Data : Mol Nutr Food Res. 2014 Jun ;58(6):1374-8. Epub 2014 Feb 24. PMID: 24668839

Article Published Date : May 31, 2014

Study Type : Human Study

Additional Links

Substances : Hibiscus sabdariffa , Polyphenols

Diseases : Cardiovascular Diseases, Endothelial Dysfunction, Hypertension, Metabolic Diseases, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants

Additional Keywords : Plant Extracts, Significant Treatment Outcome

[+]

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects.Jun 19, 2018

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Pubmed Data : Br J Clin Pharmacol. 2016 Apr 21. Epub 2016 Apr 21. PMID: 27100393

Article Published Date : Apr 20, 2016

Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men.Dec 31, 2012

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Article Published Date : Dec 31, 2012

[+]

Regular moderate intake of red wine is linked to a better women's sexual health.Sep 30, 2009

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Pubmed Data : J Sex Med. 2009 Oct ;6(10):2772-7. Epub 2009 Jul 21. PMID: 19627470

Article Published Date : Sep 30, 2009

Study Type : Human Study

Additional Links

Substances : Flavonoids, Polyphenols, Wine

Diseases : Endothelial Dysfunction, Libido: Low, Sexaul Dysfunction

[+]

Results indicate a positive impact of regular chokeberry juice consumption on BP and lipid status in pharmacologically untreated hypertensive subjects.May 13, 2015

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Pubmed Data : J Med Food. 2015 May 14. Epub 2015 May 14. PMID: 25973889

Article Published Date : May 13, 2015

Study Type : Human Study

Additional Links

Substances : Chokeberry, Polyphenols

Diseases : Blood Pressure: High, Cardiovascular Diseases, Hypertension, Triglycerides: Elevated

Pharmacological Actions : Antihypertensive Agents, Cardioprotective, Hypolipidemic

Additional Keywords : Dietary Modification, Significant Treatment Outcome

[+]

Rooibos tea improves the lipid profile and redox status of adults at risk of developing cardiovascular disease.Jan 07, 2011

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Pubmed Data : J Ethnopharmacol. 2011 Jan 7 ;133(1):46-52. Epub 2010 Sep 15. PMID: 20833235

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Pubmed Data : PeerJ. 2015 ;3:e969. Epub 2015 May 21. PMID: 26038724

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Polyphenols

Diseases : Diarrhea, Diarrhea: in Children

Pharmacological Actions : Antidiarrheals, Gastrointestinal Agents

Additional Keywords : Significant Treatment Outcome

[+]

Supplementation with 150 mg/day Oligopin® for 12 weeks exerts beneficial effects in postmenopausal osteopenia.Dec 31, 2020

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Pubmed Data : Phytomedicine. 2021 Jan ;81:153417. Epub 2020 Nov 19. PMID: 33250314

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Polyphenols

Diseases : Osteopenia, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Supplementation with green tea extract prevents exercise-induced oxidative stress.Aug 01, 2015

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Pubmed Data : Eur J Nutr. 2015 Aug ;54(5):783-91. Epub 2014 Aug 14. PMID: 25120110

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Pubmed Data : Nutrients. 2015 ;7(2):1301-17. Epub 2015 Feb 16. PMID: 25690419

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Pubmed Data : Nutrients. 2017 Jul 21 ;9(7). Epub 2017 Jul 21. PMID: 28754004

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Pubmed Data : World J Gastroenterol. 2014 Sep 14 ;20(34):12301-7. PMID: 25232265

[+]

Cultured coconut extract showed a barrier-enhancing effect and anti-inflammatory properties against UVB irradiation-induced inflammation.Jul 31, 2017

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Pubmed Data : Food Chem Toxicol. 2017 Aug ;106(Pt A):367-375. Epub 2017 May 28. PMID: 28564614

Article Published Date : Jul 31, 2017

Study Type : Human In Vitro

Additional Links

Substances : Coconut, Polyphenols

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anti-Inflammatory Agents, Photoprotective

Additional Keywords : Plant Extracts

[+]

Depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated α-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors.Jul 06, 2015

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Pubmed Data : Angew Chem Int Ed Engl. 2015 Jul 6 ;54(28):8217-21. Epub 2015 May 26. PMID: 26013280

Article Published Date : Jul 06, 2015

Study Type : Human In Vitro

Additional Links

Substances : Polyphenols, Tannic Acid

Pharmacological Actions : Neuroprotective Agents

[+]

Dietary coffee polyphenols augment gut-derived active GLP-1 secretion via the cAMP-dependent pathway, which may contribute to the reduced risk of type 2 diabetes.Dec 31, 2014

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Pubmed Data : J Nutr Sci. 2015 ;4:e9. Epub 2015 Mar 3. PMID: 26097706

Article Published Date : Dec 31, 2014

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Pubmed Data : Int J Biol Sci. 2017 ;13(8):1067-1081. Epub 2017 Sep 3. PMID: 28924387

Article Published Date : Dec 31, 2016

Study Type : Human In Vitro

Additional Links

Substances : Polyphenols

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Nrf2 activation

[+]

Polyphenol interactions mitigate the immunogenicity and allergenicity of gliadins.Feb 12, 2017

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Pubmed Data : J Agric Food Chem. 2017 Feb 13. Epub 2017 Feb 13. PMID: 28190352

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Pubmed Data : J Agric Food Chem. 2013 Oct 9 ;61(40):9697-704. Epub 2013 Sep 30. PMID: 24028635

Article Published Date : Oct 09, 2013

Study Type : Human In Vitro

Additional Links

Substances : Catechin , Polyphenols, Tea

Diseases : Hypertension

Additional Keywords : Plant Extracts

[+]

VEGF is a key molecular target for specific polyphenols found in tea, apples and cocoa which potently inhibit VEGF signalling and angiogenesis at physiological concentrations.Feb 28, 2015

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Pubmed Data : Mol Nutr Food Res. 2015 Mar ;59(3):401-12. Epub 2015 Jan 22. PMID: 25546248

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Pubmed Data : Pharmacol Res. 2012 Jun ;65(6):603-8. Epub 2012 Feb 10. PMID: 22342543

[+]

An apple peel polyphenol extract protected cells against the indomethacin-associated adverse effects in vivo.Nov 08, 2011

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Pubmed Data : J Agric Food Chem. 2011 Nov 9 ;59(21):11501-8. Epub 2011 Oct 6. PMID: 21954913

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Gut. 2005 Feb ;54(2):193-200. PMID: 15647180

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Pubmed Data : Br J Nutr. 2009 Dec;102(11):1620-8. Epub 2009 Jul 22. PMID: 19622193

Article Published Date : Dec 01, 2009

Study Type : Transgenic Animal Study

Additional Links

Substances : Apples, Flavonoids, Polyphenols

Diseases : Inflammatory Bowel Diseases, Irritable Bowel Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors

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Pubmed Data : J Nutr Biochem. 2019 Feb ;64:88-100. Epub 2018 Aug 11. PMID: 30471564

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Blueberry, Polyphenols, Prebiotics

Diseases : Obesity

Pharmacological Actions : Gastrointestinal Agents

Additional Keywords : Anti-Obesity Agents

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Boswellia is as effective as orlistat in preventing obesity, hyperlipidemia, steatosis, and insulin resistance through anti-inflammatory effects and upregulation of adiponectin.Jun 01, 2019

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Pubmed Data : Inflammopharmacology. 2019 Jun ;27(3):549-559. Epub 2018 Aug 1. PMID: 30069718

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Pubmed Data : Plant Foods Hum Nutr. 2016 Sep ;71(3):225-30. PMID: 27193017

Article Published Date : Sep 01, 2016

Study Type : Animal Study

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Substances : Fiber, Polyphenols

Diseases : Dyslipidemias

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic

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Chokeberry fruit derivatives may act as a promising supplementary therapeutic option in the prevention and treatment of disorders occurring in metabolic syndrome, as well as their complications.Nov 30, 2008

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Pubmed Data : Plant Foods Hum Nutr. 2008 Dec ;63(4):176-82. Epub 2008 Aug 23. PMID: 18726160

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Redox Biol. 2015 Jun 26 ;6:206-217. Epub 2015 Jun 26. PMID: 26262997

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Pubmed Data : Curr Drug Targets. 2015 Jan 2. Epub 2015 Jan 2. PMID: 25557255

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2020 Nov 16 ;25(22). Epub 2020 Nov 16. PMID: 33207644

Article Published Date : Nov 15, 2020

Study Type : Animal Study

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Substances : Grape Seed Extract, Polyphenols

Diseases : Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Neuroprotective Agents

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Effects of green tea polyphenols on iodide-induced autoimmune thyroiditis in nonobese diabetic mice.Dec 31, 2012

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:912769. Epub 2013 Feb 27. PMID: 23533529

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Chokeberry, Polyphenols

Diseases : Hypertension: Arterial, Oxidative Stress

Pharmacological Actions : Antihypertensive Agents, Antioxidants, Prophylactic Agents

Additional Keywords : Prophylactic

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Exosomes transport trace amounts of polyphenols.Aug 17, 2020

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Pubmed Data : Food Funct. 2020 Aug 18. Epub 2020 Aug 18. PMID: 32808000

Article Published Date : Aug 17, 2020

Study Type : Animal Study

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Substances : Polyphenols

Additional Keywords : Exosomes

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Fenugreek (Trigonella foenum graecum) seed polyphenols protects the liver from alcohol toxicity. Apr 01, 2007

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Pubmed Data : Pharmazie. 2007 Apr;62(4):299-304. PMID: 17484288

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Pubmed Data : J Sci Food Agric. 2017 Apr ;97(6):1910-1915. Epub 2016 Sep 22. PMID: 27539359

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Black Tea, Fermented Foods and Beverages, Green Tea, Polyphenols

Diseases : Liver Damage: Aflatoxin-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Aflatoxin

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Fish oil increases adiponectin and a combination of fish oil and apple polyphenols decrease cholesterol and oxidative stress.Jan 01, 2017

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2017 ;63(1):21-27. PMID: 28367922

Article Published Date : Jan 01, 2017

Study Type : Animal Study

Additional Links

Substances : Fish Oil, Polyphenols

Diseases : Adiponectin: Low Levels, High Cholesterol, Oxidative Stress

Pharmacological Actions : Adiponectin upregulation, Anticholesteremic Agents, Antioxidants

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Pubmed Data : J Toxicol Sci. 2010;35(3):357-64. PMID: 20519844

Article Published Date : Jan 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Grape Seed Extract, Polyphenols

Diseases : MRSA

Pharmacological Actions : Anti-Bacterial Agents, Antioxidants

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Grape seed extract has inhibiting effect on the accumulation of age-related oxidative DNA damages in the central nervous system of rats. Feb 15, 2006

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Pubmed Data : Brain Res Bull. 2006 Feb 15;68(6):469-73. Epub 2005 Nov 2. PMID: 16459205

Article Published Date : Feb 15, 2006

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Aging: Brain , DNA damage, Neurodegenerative Diseases

Pharmacological Actions : Antioxidants, Neuroprotective Agents

Additional Keywords : Plant Extracts, Proanthocyanidins

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Grape seed extract prevents adverse metabolic alterations through tis anti-inflammatory and antioxidant action.Oct 01, 2017

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Pubmed Data : Phytother Res. 2017 Oct ;31(10):1621-1632. Epub 2017 Aug 25. PMID: 28840618

Article Published Date : Oct 01, 2017

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Polyphenols

Diseases : Adiponectin: Low Levels, Inflammation, Insulin Resistance, Obesity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

Problem Substances : Insulin

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Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.Feb 10, 2009

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Pubmed Data : Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755

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Green tea prevents and reverses fasting-induced intestinal mucosal damage. Jun 01, 2003

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Pubmed Data : Nutrition. 2003 Jun;19(6):536-40. PMID: 12781855

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Pubmed Data : J Nutr. 2007 Mar;137(3):634-40. PMID: 17311952

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate), Green Tea, Polyphenols

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Antineoplastic Agents

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Hawthorn polyphenol extract inhibits UVB-induced skin photoaging.Aug 14, 2018

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Pubmed Data : J Agric Food Chem. 2018 Aug 15 ;66(32):8537-8546. Epub 2018 Jul 31. PMID: 30032605

Article Published Date : Aug 14, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:480714. Epub 2011 Oct 15. PMID: 22013489

Article Published Date : Dec 31, 2011

Study Type : Animal Study

Additional Links

Substances : Phellinus Linteus, Polyphenols

Diseases : Chemically-Induced Liver Damage, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.Jan 04, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Death Dis. 2017 10 5 ;8(10):e3089. Epub 2017 Oct 5. PMID: 28981104

Article Published Date : Jan 04, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Phellinus Linteus, Polyphenols

Diseases : Cervical Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Cell cycle arrest

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Additional Keywords : Xanthones

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Mango polyphenolics might be relevant as preventive agents in ulcerative colitis.Apr 05, 2016

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Pubmed Data : Mol Carcinog. 2016 Apr 6. Epub 2016 Apr 6. PMID: 27061150

Pubmed Data : Eur J Nutr. 2015 May 1. Epub 2015 May 1. PMID: 25930965

Article Published Date : Apr 30, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fruit Peel, Polyphenols

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Bax/Bcl2 Ratio: Decrease, Caspase-3 Activation, Cell cycle arrest, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Dose Response, Plant Extracts

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Peach polyphenols inhibited tumor growth and reduced the risk of metastasis in MDA-MB-435 cells at levels achievable with diet.Mar 18, 2014

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Pubmed Data : J Nutr Biochem. 2014 Mar 19. Epub 2014 Mar 19. PMID: 24745759

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Pubmed Data : Food Chem Toxicol. 2008 Jan;46(1):175-85. Epub 2007 Jul 28. PMID: 17804140

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Pine Needle, Polyphenols

Diseases : Cholesterol: Oxidation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors

[+]

Plant-derived polyphenols prevent fatty liver disease through by regulating the expressions of miRNA .Jun 30, 2012

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Pubmed Data : Biochim Biophys Acta. 2012 Jul ;1820(7):894-9. Epub 2012 Apr 5. PMID: 22503922

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View the Evidence: 699 Abstracts with Polyphenols Research

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Daily grape polyphenol intake can significantly reduce the systolic blood pressure in humans.Dec 31, 2014

Endothelial function can be significantly improved in healthy adults in the initial 2 hours after intake of grape polyphenols.Dec 31, 2012

The effect of grape products containing polyphenols on C-reactive protein levels.Sep 13, 2020

There are statistically significant and meaningful differences in nutritional composition between organic and non-organic crops and crop based foods.Jun 25, 2014

This review provides support for the use of polyphenol-rich interventions for improving cardiovascular risk markers in haemodialysis patients.Dec 10, 2017

High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio.Nov 01, 2010

Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans.Dec 31, 1998

28‐days of polyphenol supplementation modulates the acute JNK, BAD, and Bcl‐2 response to heavy resistance exercise.Dec 31, 2017

A Chinese green tea polyphenol extract has evident anti-plaque effect.Sep 01, 2000

A citrus polyphenol extract improved both overweight process and correlated skeletal muscle mass metabolism.Jun 02, 2015

A combination of polyphenols reduced diastolic pressure by potentiating eNOS activation and nitric oxide production.Jun 09, 2015

A joint consumption of apple juice, natural antioxidants and polyphenols might provide mild favorable effects on cardiometabolic markers, as compared to apple polyphenols alone.Nov 30, 2014

A polyphenol and antioxidant rich fruit and vegetable concentrate has therapeutic value in HIV patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis. Feb 01, 2004

A polyphenol content of the diet was associated with reduced mortality risk in a Mediterranean population.Nov 27, 2017

A polyphenol pattern provided by a diet containing specific plant products was associated with lower dementia risk.May 28, 2018

A polyphenol-rich beverage reduces symptoms associated with the common cold.Oct 01, 2010

A polyphenol-rich whole food supplement significantly effected the rate of PSA progression among men with prostate cancer.Mar 10, 2014

Administration of Pycnogenol leads in improvement of erectile function in patients with diabetes.Dec 31, 2018

An acute dose of cranberry beverages improved biomarkers of antioxidant status and inhibition of bacterial adhesion in urine. Apr 30, 2014

Antioxidant protection from bioactive compounds present in fruit and vegetables could have an adjuvant role in fibromyalgia treatment.Nov 20, 2016

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils. Sep 09, 2009

Aronia berry polyphenol consumption reduces plasma total and low-density lipoprotein cholesterolDec 31, 2016

Bilberry has anti-inflammatory properties.Sep 01, 2010

Black tea consumption can decrease postprandial blood glucose after sucrose intake.Dec 31, 2016

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.Sep 01, 2008

Boswellia resin extract and propolis derived polyphenols can reduce genitourinary pain and then improve quality of life of men affected by prostatitis-like symptoms.Jan 13, 2020

Brazilian native fruit juices decrease postprandial glycemia in healthy subjects.Jan 10, 2017

Cocoa inhibits LDL oxidation both in vitro and ex vivo.Apr 06, 1999

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers. Oct 15, 2010

Coffee bean polyphenols ameliorate postprandial endothelial dysfunction in healthy male adults.May 01, 2015

Coffee polyphenols extracted from green coffee beans improve skin properties and microcirculatory function.Aug 31, 2017

Consumption of a polyphenol-rich grape-wine extract lowers ambulatory blood pressure in mildly hypertensive subjects.Apr 29, 2015

Consumption of either NPJ or HPJ protected against DNA damage and lipid peroxidation, modified several antioxidant enzymes, and reduced body weight.Jul 31, 2015

Consumption of mango improves symptoms and associated biomarkers of constipation beyond an equivalent amount of fiber.May 06, 2018

Consumption of olive oil polyphenols decreased plasma LDL concentrations and LDL atherogenicity in healthy young men.Jun 30, 2015

Consumption of phytochemical-rich foods may prevent the development of hypertension.Feb 28, 2015

Consumption of polyphenols results in a significant improvement in an established marker of cardiovascular risk in hypertensive participants.May 09, 2016

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.Jun 02, 2009

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans.Dec 01, 2008

Diets rich in polyphenols and omega-3s improve postprandial dyslipidemia and oxidative stress.Mar 01, 2014

Fruit and vegetable consumption and their polyphenol content are inversely associated with sleep duration.Nov 19, 2018

Gazpacho soup consumption is associated with a lower prevalence of hypertension.Sep 30, 2013

Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome.Aug 31, 2012

Grape pomace phenolic extract reduces trimethylamine-n-oxide levels in humans.Jan 10, 2019

Grape pomace polyphenols and pectin reduce trimethylamine-n-oxide serum levels.Jan 01, 2019

Grape pomace polyphenols reduce postprandial insulin levels and improve insulin sensitivity.Jan 12, 2019

Green tea drinkers with susceptible IGF1 (CA)19/(CA)19 and (CA)19/X genotypes had a significant reduced risk of lung cancer.Jan 01, 2012

Green tea drinking suppresses proliferation of HTLV-1-infected lymphocytes in vivo.Jul 01, 2004

Green tea extract decreased fasting insulin concentrations in those with elevated baseline fasting concentrations.Jan 01, 2016

Green tea induced changes in NFκB and systemic oxidation, and uptake of GT polyphenols in prostate tissue they may have a role in prostate cancer prevention and treatment.Mar 31, 2015

Green tea polyphenol treatment could have potential beneficial effects on LDL-cholesterol concentrations.Jun 30, 2016

H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure.May 31, 2014

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects.Jun 19, 2018

Hibiscus sabdariffa exerts beneficial effects on inflammation, endothelial dysfunction, and oxidation, systemically inhibits the renin-angiotensin system and angiotensin-converting enzyme.Sep 01, 2015

High concentrations of polyphenols, a nutritional biomarker of polyphenol intake, were associated with lower risk of substantial cognitive decline in an older population studied over a 3-year period.Apr 30, 2015

High dietary intake of polyphenols may be associated with longevity. Aug 31, 2013

High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites.Jul 31, 2014

Increases in dietary polyphenols are associated with decreased inflammatory biomarkers.Apr 20, 2016

Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly People at high cardiovascular disease risk.Mar 08, 2016

Long-term green tea polyphenol supplementation could be an efficient protection against the health issues induced by high-voltage power lines.Aug 31, 2016

Medium-term administration of onion peel extract an improvement in flow-mediated dilation and circulating endothelial progenitor cells.Aug 31, 2015

Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention.Jan 31, 2008

Natural ice cream rich in polyphenols improved vascular function and physical performance in healthy people through a reduction in oxidative stress.Dec 31, 2016

Nutritional doses of grape polyphenols protects against fructose induced oxidative stress and insulin resistance.May 31, 2013

Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men.Dec 31, 2012

Participants with high intake of chocolate products and cocoa-derived flavanols experience a reduced risk of developing T2D.May 23, 2018

Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive patients. Oct 01, 2000

Polyphenol rich berry juices reduce blood pressure in hypertensive patients more so than in normotensive subjects.Oct 13, 2015

Polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects.Jan 31, 2017

Pomegranate juice consumption appears to slow the progression of the carotid intima-media thickness in subjects with increased oxidative stress and poor blood lipid profiles. Oct 01, 2009

Propolis has radioprotective properties.Aug 01, 2009

Raspberries lower postprandial hyperglycemia and inflammation.Jan 01, 2019

Polyphenols

View the Evidence:
699 Abstracts with Polyphenols Research