Sesamol

Views 3024
Jump to
Abstracts Focused Research Topics
Download the GMI DOC on this Topic

Focus Your Research

Click any topic below to filter + focus research
73 Diseases Researched for Sesamol
NameACCKFocus
Oxidative Stress2135Locked
Lipid Peroxidation1425Locked
Inflammation913Locked
Lipopolysaccharide-Induced Toxicity59Locked
Chemotherapy and Radiation Toxicity36Locked
Kidney Damage36Locked
Liver Damage36Locked
Chemically-Induced Liver Damage24Locked
Cognitive Decline/Dysfunction24Locked
Diabetes: Cognitive Dysfunction24Locked
Huntington Disease24Locked
Hyperlipidemia24Locked
Hypertension24Locked
Inflammatory Bowel Diseases24Locked
Memory Disorders24Locked
Brain: Oxidative Stress23Locked
Chemotherapy-Induced Toxicity: Doxorubicin23Locked
Colon Cancer23Locked
DNA damage23Locked
Radiation Induced Illness23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Aluminum Toxicity 12Locked
Arthritis12Locked
Atherosclerosis12Locked
Blood-Brain-Barrier Disorders12Locked
Brain Damage12Locked
Brain Inflammation 12Locked
Candida Albicans22Locked
Cataract12Locked
Cerebral Ischemia12Locked
Depression12Locked
Diabetic Neuropathies12Locked
Endothelial Dysfunction12Locked
Endotoxemia12Locked
Enterocolitis: Necrotiziing12Locked
Epilepsy12Locked
Gastric Ulcer12Locked
High Fat Diet12Locked
High Fructose Diet12Locked
Lung Infection12Locked
Lung Injury: Acute12Locked
Memory Impairment: Hormone Deficiency Induced12Locked
Menopausal Syndrome12Locked
Myocardial Infarction12Locked
Myocardial Infarction: Prevention12Locked
Neuropathic Pain12Locked
Obesity12Locked
Pancreatitis12Locked
Parkinson's Disease12Locked
Postmenopausal Disorders: Memory Impairment12Locked
Radiation Disaster Associated Toxicity12Locked
Respiratory Infections12Locked
Sepsis12Locked
Sinusoidal obstruction syndrome12Locked
Skin Cancer12Locked
Stroke: Ischemic12Locked
Triglycerides: Elevated12Locked
Wound Healing12Locked
Anemia11Locked
Candida Infection 11Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide11Locked
Freckles11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Melasma11Locked
Osteoporosis11Locked
Progesterone: Low11Locked
Skin Diseases: Photo-Aging11Locked
Staphylococcus aureus infection11Locked
Streptococcus pneumoniae infection11Locked
Testicular Cancer11Locked
Tuberculosis: Drug Resistant11Locked
50 Pharmacological Actions Researched for Sesamol
NameACCKFocus
Antioxidants3561Locked
Neuroprotective Agents1223Locked
Anti-Inflammatory Agents1221Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor916Locked
Radioprotective611Locked
Apoptotic79Locked
Glutathione Upregulation 48Locked
Renoprotective48Locked
Gastroprotective36Locked
Hepatoprotective36Locked
Interleukin-1 beta downregulation46Locked
Cyclooxygenase 2 Inhibitors35Locked
Anti-Apoptotic24Locked
Cardioprotective24Locked
Chemopreventive24Locked
Chemoprotective Agents34Locked
Interleukin-6 Downregulation24Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor24Locked
NF-kappaB Inhibitor34Locked
Anti-Adipogenic23Locked
Nitric Oxide Inhibitor23Locked
Nrf2 activation23Locked
Prostaglandin PGE2 downregulation23Locked
Superoxide Dismutase Up-regulation23Locked
Anti-atherogenic12Locked
Anticarcinogenic Agents12Locked
Anticonvulsants12Locked
Antidepressive Agents12Locked
Antifungal Agents22Locked
Antihypertensive Agents12Locked
Bcl-2 protein down-regulation12Locked
Brain-derived neurotrophic factor modulator12Locked
Caspase-3 Inhibition12Locked
Catalase Up-Regulation12Locked
Chondroprotective12Locked
Cyclooxygenase Inhibitors12Locked
Enzyme Inhibitors12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor12Locked
Mitochondrial Superoxide Dismutase Upregulation12Locked
Anti-Bacterial Agents11Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Antiproliferative 11Locked
Autophagy Inhibitors11Locked
Cell cycle arrest11Locked
Lipoxygenase Inhibitors11Locked
Secretagogue11Locked
Steroidogenesis11Locked
Tyrosinase Inhibition11Locked
Related Topics

Sesamol is a Sub of the following Topic

View the Evidence:
77 Abstracts with Sesamol Research

[+]

ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders.Jun 04, 2019

Pubmed Data : J Agric Food Chem. 2019 Jun 5 ;67(22):6190-6201. Epub 2019 May 28. PMID: 31117496
Article Published Date : Jun 04, 2019
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gut-brain Axis
[+]

Both free and encapsulated sesamol demonstrated inhibition of tumor progression by inducing skin cell apoptosis via bcl-2/bax mediated pathway.Aug 18, 2016

Pubmed Data : Anticancer Agents Med Chem. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27539478
Article Published Date : Aug 18, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Elevated levels of cholesterol and triacylglycerol were significantly reversed by the sesamol.May 31, 2013

Pubmed Data : Lipids. 2013 Jun ;48(6):633-8. Epub 2013 Mar 17. PMID: 23504268
Article Published Date : May 31, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hyperlipidemia, Triglycerides: Elevated
Pharmacological Actions : Antioxidants
[+]

Oral supplementation of sesamol and sesamin beneficially modulated the inflammatory and oxidative stress markers.Feb 28, 2017

Pubmed Data : J Nutr Biochem. 2017 Mar ;41:151-157. Epub 2016 Dec 29. PMID: 28095362
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamin, Sesamol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Sesamin may prevent the development of atherosclerosis and inflammatory responsesSep 01, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lignans, Sesamol
Diseases : Atherosclerosis, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sesamol ameliorates diet-induced obesity in C57BL/6J mice.Dec 23, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Dec 24. Epub 2016 Dec 24. PMID: 28012248
Article Published Date : Dec 23, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Obesity
Pharmacological Actions : Anti-Adipogenic
Additional Keywords : Anti-Obesity Agents
[+]

Sesamol ameliorates high-fat and high-fructose induced cognitive defects.Jan 18, 2017

Pubmed Data : Food Funct. 2017 Jan 19. Epub 2017 Jan 19. PMID: 28102395
Article Published Date : Jan 18, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, High Fructose Diet, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol as a single prophylactic dose protects hematopoietic and gastrointestinal systems against γ-radiation-induced injury in mice.Dec 31, 2014

Pubmed Data : Free Radic Res. 2015 ;49(11):1344-61. Epub 2015 Aug 12. PMID: 26156438
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Radioprotective
[+]

Sesamol attenuates diabetes-associated cognitive decline in rats. Mar 01, 2008

Pubmed Data : Exp Brain Res. 2008 Mar ;185(3):411-20. Epub 2007 Oct 23. PMID: 17955223
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Diabetes: Cognitive Dysfunction, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.Oct 01, 2008

Pubmed Data : Shock. 2008 Oct ;30(4):456-62. PMID: 18277948
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Gastric Ulcer, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase Inhibitors, Gastroprotective
Problem Substances : Diclofenac
Adverse Pharmacological Actions : Irritant
[+]

Sesamol attenuates experimentally induced Huntington-like changes in an animal model. Jan 01, 2009

Pubmed Data : J Asian Nat Prod Res. 2009 ;11(5):439-50. PMID: 19504387
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Huntington Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol attenuates experimentally induced myocardial infarction. Jan 01, 2011

Pubmed Data : Cell Physiol Biochem. 2011 ;27(3-4):273-80. Epub 2011 Apr 1. PMID: 21471716
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hypertension, Myocardial Infarction
Pharmacological Actions : Antioxidants, Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Sesamol attenuates lipopolysaccharide induced hypotension by regulating the circulating inflammatory response.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2015 ;14:948-57. Epub 2015 Aug 13. PMID: 26839527
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hypertension, Inflammation, Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Renoprotective
[+]

Sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome.Jun 17, 2011

Pubmed Data : Cell Biochem Biophys. 2011 Jun 17. Epub 2011 Jun 17. PMID: 21681587
Article Published Date : Jun 17, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Sinusoidal obstruction syndrome
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.Mar 31, 2012

Pubmed Data : Hum Exp Toxicol. 2012 Apr ;31(4):397-404. Epub 2011 Nov 10. PMID: 22076497
Article Published Date : Mar 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Oxidative Stress, Pancreatitis
Pharmacological Actions : Antioxidants
[+]

Sesamol attenuates the renoinflammatory cascade in experimental model of diabetic nephropathy. Jul 22, 2009

Pubmed Data : J Agric Food Chem. 2009 Jul 22 ;57(14):6123-8. PMID: 19601660
Article Published Date : Jul 22, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Renoprotective
[+]

sesamol could be a potential neuroprotective agent during aging process due to its beneficial effects on liver-brain axis.Nov 13, 2018

Pubmed Data : Food Funct. 2018 Nov 14 ;9(11):5912-5924. PMID: 30375618
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain: Oxidative Stress, Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Brain-derived neurotrophic factor modulator, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Gut-liver axis
[+]

Sesamol delays mortality and attenuates liver injury. May 01, 2006

Pubmed Data : Shock. 2006 May ;25(5):528-32. PMID: 16680019
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Liver Damage, Oxidative Stress
Pharmacological Actions : Hepatoprotective
[+]

Sesamol exerts ameliorative effects in the experimental model of epilepsy.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2014 Feb ;17(2):100-7. PMID: 24711892
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Epilepsy, Oxidative Stress
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Sesamol exhibits anti-depressant properties.Apr 01, 2011

Pubmed Data : Psychopharmacology (Berl). 2011 Apr ;214(4):819-28. Epub 2010 Nov 20. PMID: 21103863
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Depression, Lipid Peroxidation
Pharmacological Actions : Antidepressive Agents, Catalase Up-Regulation, Glutathione Upregulation , Superoxide Dismutase Up-regulation
[+]

Sesamol has neuroprotective properties. Jun 01, 2011

Pubmed Data : Eur J Pharmacol. 2011 Jun 1 ;659(2-3):177-86. Epub 2011 Apr 2. PMID: 21463622
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain Damage, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol has protective effects on mucosal in Inflammatory bowel disease.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2014 ;2014:802701. Epub 2014 Jan 30. PMID: 24616646
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Gastroprotective
[+]

Sesamol has radioprotective properties. Sep 01, 2009

Pubmed Data : Environ Toxicol Pharmacol. 2009 Sep ;28(2):192-7. Epub 2009 Apr 11. PMID: 21784002
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Oxidative Stress, Radiation Disaster Associated Toxicity
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2013 ;2013:934239. Epub 2013 Oct 21. PMID: 24228260
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Sesamol has strong potential to protect hematopoietic system by lowering radiation induced DNA damages.Aug 01, 2017

Pubmed Data : Environ Mol Mutagen. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28766757
Article Published Date : Aug 01, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
[+]

Sesamol has therapeutic value in ovariectomy-induced pathophysiological changes.Sep 26, 2012

Pubmed Data : Climacteric. 2012 Sep 27. Epub 2012 Sep 27. PMID: 23017032
Article Published Date : Sep 26, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Memory Impairment: Hormone Deficiency Induced, Menopausal Syndrome, Postmenopausal Disorders: Memory Impairment
Additional Keywords : Ovariectomy-Induced Changes
[+]

Sesamol has wound healing properties.Jan 27, 2011

Pubmed Data : J Ethnopharmacol. 2011 Jan 27 ;133(2):608-12. Epub 2010 Oct 28. PMID: 21035533
Article Published Date : Jan 27, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Wound Healing
Pharmacological Actions : Antioxidants
Additional Keywords : Science Confirms Tradition
Problem Substances : Dexamethasone
[+]

Sesamol improves blood-brain-barrier function in diabetic rats. Jul 01, 2009

Pubmed Data : Exp Brain Res. 2009 Jul ;197(1):23-34. Epub 2009 Jun 30. PMID: 19565232
Article Published Date : Jul 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Sesamol
Diseases : Blood-Brain-Barrier Disorders, Diabetes: Cognitive Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sesamol induced functional improvements during 5 days after middle cerebral artery occlusion.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Phys Ther Sci. 2015 Jun ;27(6):1771-3. Epub 2015 Jun 30. PMID: 26180317
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol induced mitochondrial protection in LPS-treated cells by a mechanism involving heme oxigenase-1.Dec 24, 2018

Pubmed Data : Chem Biol Interact. 2018 Dec 25 ;296:171-178. Epub 2018 Sep 24. PMID: 30261164
Article Published Date : Dec 24, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Lipopolysaccharide-Induced Toxicity, Mitochondrial Dysfunction
Pharmacological Actions : Anti-Apoptotic
[+]

Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2019 ;63. Epub 2019 Oct 23. PMID: 31692782
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Sesamol mitigated Lipopolysaccharide induced amyloidogenesis and memory impairment.Nov 14, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 15. Epub 2016 Nov 15. PMID: 27860258
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Sesamol protects against acetaminophen-induced injury in animals.Jul 01, 2009

Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Tylenol
Adverse Pharmacological Actions : Hepatotoxic, Oxidant
[+]

Sesamol protects against chemically-induced acute kidney injury in mice. Aug 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Aug ;46(8):2736-41. Epub 2008 Apr 29. PMID: 18539378
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Sesamol protects against chemically-induced liver damage in rats. Nov 01, 1994

Pubmed Data : Yakugaku Zasshi. 1994 Nov ;114(11):901-10. PMID: 7853152
Article Published Date : Nov 01, 1994
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemically-Induced Liver Damage, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Sesamol protects against chemically-induced oxidative renal injury in rats. Apr 01, 2009

Pubmed Data : Basic Clin Pharmacol Toxicol. 2009 Apr ;104(4):316-21. Epub 2009 Feb 27. PMID: 19281599
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol protects against cognitive dysfunction and altered glutathione redox balance. Jul 01, 2010

Pubmed Data : Basic Clin Pharmacol Toxicol. 2010 Jul ;107(1):577-82. Epub 2010 Jan 25. PMID: 20102363
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Cognitive Decline/Dysfunction, Huntington Disease, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Sesamol protects against myocardial infarction. Jan 01, 2010

Pubmed Data : Redox Rep. 2010 ;15(1):36-42. PMID: 20196927
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Myocardial Infarction: Prevention
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Mitochondrial Superoxide Dismutase Upregulation
[+]

Sesamol protects against radiation-induced cytotoxicity in mice. Dec 10, 2006

Pubmed Data : Mutat Res. 2006 Dec 10 ;611(1-2):9-16. Epub 2006 Oct 11. PMID: 17045515
Article Published Date : Dec 10, 2006
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Radiation Induced Illness
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Sesamol reduces pulmonary inflammatory response and lung injury in endotoxemic rats.Jul 01, 2010

Pubmed Data : Food Chem Toxicol. 2010 Jul ;48(7):1821-6. Epub 2010 Apr 14. PMID: 20398721
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity, Lung Infection, Lung Injury: Acute, Respiratory Infections
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol reduces total oxidant status, malondialdehyde levels and inhibits cataract formation.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Ophthalmol. 2017 Dec ;47(6):309-314. Epub 2017 Dec 27. PMID: 29326846
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Cataract
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Malondialdehyde Down-regulation
[+]

Sesamol supplementation may serve as potent adjuvant in the treatment of focal cerebral ischemia-reperfusion injury.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Jul ;14(1):841-847. Epub 2017 Jun 6. PMID: 28673008
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID: 24688218
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Sesamol suppresses neuropathic pain associated with diabetes.Oct 01, 2010

Pubmed Data : J Pain. 2010 Oct ;11(10):950-7. Epub 2010 Apr 24. PMID: 20418182
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Diabetic Neuropathies, Inflammation, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Caspase-3 Inhibition
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats.Mar 31, 2015

Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):327-36. PMID: 25829772
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Aluminum Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum
[+]

The protective effects of sesamol in a neonatal rat model of necrotizing enterocolitis.Jul 28, 2018

Pubmed Data : J Matern Fetal Neonatal Med. 2018 Jul 29:1-11. Epub 2018 Jul 29. PMID: 30058400
Article Published Date : Jul 28, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Enterocolitis: Necrotiziing
Pharmacological Actions : Antioxidants, Gastroprotective
[+]

The results strongly suggest the radioprotective efficacy of sesamol in the haematopoietic system of mice.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mutagenesis. 2015 Sep ;30(5):651-61. Epub 2015 Apr 11. PMID: 25863274
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy and Radiation Toxicity, DNA damage
Pharmacological Actions : Radioprotective
[+]

These results demonstrated that sesamol is a potent depigmenting agent in the animal model.Jul 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Jul 5 ;8(7). Epub 2019 Jul 5. PMID: 31284438
Article Published Date : Jul 04, 2019
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hyperpigmentation, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
[+]

This concludes the mucosal protective effect of sesamol on colon due to its potent antioxidant actions.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Rep. 2013 ;65(3):658-65. PMID: 23950588
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Sep 30, 2013

Pubmed Data : Eur J Nutr. 2013 Oct ;52(7):1787-99. Epub 2012 Dec 27. PMID: 23269651
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Arthritis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study demonstrates the cellular mechanisms underlying the protective effects of sesamol and sesame oil against atherosclerosis.Jul 31, 2015

Pubmed Data : Eur J Nutr. 2015 Aug ;54(5):691-700. Epub 2014 Aug 1. PMID: 25081501
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesame Seed Oil , Sesamol
Diseases : Hyperlipidemia
Pharmacological Actions : Anti-atherogenic
[+]

This study demonstrates the comprehensive role of sesamol and naringenin in neuro and myoprotection.Dec 18, 2013

Pubmed Data : Neuroscience. 2013 Dec 19 ;254:379-94. Epub 2013 Sep 24. PMID: 24070629
Article Published Date : Dec 18, 2013
Study Type : Animal Study
Additional Links
Substances : Naringenin , Sesamol
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

High concentrations of sesamol induced the mitochondrial apoptosis pathway in human colon cancer HCT116 cells.Jul 31, 2016

Pubmed Data : Life Sci. 2016 Aug 1 ;158:46-56. Epub 2016 Jun 17. PMID: 27328416
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans.Apr 13, 2011

Pubmed Data : J Agric Food Chem. 2011 Apr 13 ;59(7):3214-9. Epub 2011 Mar 10. PMID: 21391595
Article Published Date : Apr 13, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesame Seeds, Sesamol
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity.Dec 31, 2016

Pubmed Data : Int J Biol Macromol. 2017 Jan ;94(Pt B):781-787. Epub 2016 Jun 15. PMID: 27316769
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Lipoxygenase Inhibitors
[+]

Mechanistic insights into the mode of action of the anti-candidal effect of sesamol.Aug 31, 2016

Pubmed Data : Microb Pathog. 2016 Sep ;98:140-8. Epub 2016 Jul 5. PMID: 27392701
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
[+]

Review: Sesamol has significant antioxidant properties. Jul 01, 2009

Pubmed Data : Med Chem. 2009 Jul ;5(4):367-71. PMID: 19689394
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Role of L-type amino acid transporter 1 for the selective cytotoxicity of sesamol in human melanoma cells.Oct 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Oct 27 ;24(21). Epub 2019 Oct 27. PMID: 31717859
Article Published Date : Oct 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Selective Cytotoxicity
[+]

Sesame seed extract has antimicrobial properties. Jan 01, 2007

Pubmed Data : Afr J Tradit Complement Altern Med. 2007 ;4(4):427-33. Epub 2007 Jun 10. PMID: 20161911
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sesame Seeds, Sesamol
Diseases : Candida Infection , Staphylococcus aureus infection, Streptococcus pneumoniae infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Science Confirms Tradition
[+]

Sesame seed oil does not contain significant quantities of sesamol. Sep 01, 1987

Pubmed Data : Contact Dermatitis. 1987 Sep ;17(3):133-5. PMID: 3677654
Article Published Date : Sep 01, 1987
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesamol
[+]

Sesame seeds essential oil and sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med J Islam Repub Iran. 2018 ;32:98. Epub 2018 Oct 10. PMID: 30788333
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sesame Seed Oil , Sesamol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamin and sesamol attenuate hydrogen peroxide-induced oxidative stress on human neuronal cells.Mar 29, 2019

Pubmed Data : Nutr Neurosci. 2019 Mar 30:1-12. Epub 2019 Mar 30. PMID: 30929586
Article Published Date : Mar 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sesamin, Sesamol
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol ameliorated inflammatory and oxidative damage.Jul 31, 2015

Pubmed Data : Inflamm Res. 2015 Aug ;64(8):577-88. Epub 2015 Jun 10. PMID: 26059394
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Nrf2 activation, Prostaglandin PGE2 downregulation
[+]

Sesamol down-regulates the lipopolysaccharide-induced inflammatory response.Oct 01, 2010

Pubmed Data : Innate Immun. 2010 Oct ;16(5):333-9. Epub 2009 Nov 25. PMID: 19939906
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol exhibited high antioxidant and anti-tyrosinase activity Feb 28, 2014

Pubmed Data : J Cosmet Sci. 2014 Mar-Apr;65(2):69-79. PMID: 24797023
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Tyrosinase Inhibition
[+]

Sesamol exhibits potent antimycobacterial activity.Jul 18, 2017

Pubmed Data : J Glob Antimicrob Resist. 2017 Jul 19 ;10:228-237. Epub 2017 Jul 19. PMID: 28735047
Article Published Date : Jul 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Tuberculosis: Drug Resistant
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Biofilm, Natural Substance/Drug Synergy
[+]

Sesamol has anti-adipogenic effects of on human mesenchymal stem cells.Dec 31, 2015

Pubmed Data : Biochem Biophys Res Commun. 2016 Jan 1 ;469(1):49-54. Epub 2015 Nov 23. PMID: 26616060
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Anemia, Osteoporosis
Pharmacological Actions : Anti-Adipogenic, Antioxidants
Additional Keywords : Mesenchymal Stem Cells
[+]

Sesamol induces apoptosis through both pathways in human lung adenocarcinoma (SK-LU-1) cells.Jul 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Jul 25 ;254:109-16. Epub 2016 Jun 4. PMID: 27270451
Article Published Date : Jul 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Sesamol induces cell death and up-regulates progesterone production in mouse testical tumor cells.Sep 06, 2011

Pubmed Data : J Agric Food Chem. 2011 Sep 6. Epub 2011 Sep 6. PMID: 21863802
Article Published Date : Sep 06, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Progesterone: Low, Testicular Cancer
Pharmacological Actions : Apoptotic, Secretagogue, Steroidogenesis
[+]

Sesamol is a powerful radioprotective substance.Sep 07, 2011

Pubmed Data : Radiat Res. 2011 Sep 7. Epub 2011 Sep 7. PMID: 21899433
Article Published Date : Sep 07, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Radiation Induced Illness
Pharmacological Actions : Radioprotective
[+]

Sesamol is an effectual antifungal agent that could be competently employed in treating Candida infections.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pathog. 2014 ;2014:895193. Epub 2014 Dec 9. PMID: 25574401
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
[+]

Sesamol prevents UVB-induced damage to cultured skin cells. Dec 01, 2010

Pubmed Data : Arch Dermatol Res. 2010 Dec ;302(10):733-44. Epub 2010 Aug 10. PMID: 20697726
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : DNA damage, Lipid Peroxidation, Oxidative Stress, Skin Diseases: Photo-Aging
Pharmacological Actions : Antioxidants, Apoptotic, Superoxide Dismutase Up-regulation
[+]

Sesamol represents a new skin-whitening agent for use in cosmetics.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Dermatol. 2015 Oct ;24(10):761-6. Epub 2015 Jul 14. PMID: 26010596
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Freckles, Melasma
Pharmacological Actions : Antioxidants
[+]

There is ample evidence suggesting that sesamol possesses potent anti-cancer properties in vitro and in vivo.Jul 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 15 ;855:75-89. Epub 2019 May 4. PMID: 31063773
Article Published Date : Jul 14, 2019
Study Type : Review
Additional Links
Substances : Sesamol
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These data suggest that mitochondria play an essential role in sesamol-induced HepG2 cells death.Apr 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Apr 4 ;7:45728. Epub 2017 Apr 4. PMID: 28374807
Article Published Date : Apr 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Inhibitors
[+]

This reflects the significance of sesamol in ameliorating the deleterious effects associated with cancer chemotherapy.Jun 30, 2013

Pubmed Data : J Pharm Pharmacol. 2013 Jul ;65(7):1083-93. Epub 2013 Apr 22. PMID: 23738736
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Additional Keywords : Drug: Doxorubicin
[+]

This study clearly demonstrated the potentiality of sesamol against cyclophosphamide induced organ toxicity and oxidative stress.Dec 31, 2013

Pubmed Data : Anticancer Agents Med Chem. 2014 ;14(7):975-83. PMID: 24372526
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents

Copyright: baibaz / 123RF Stock Photo

Sesamol Related Articles

Open Sesame! 10 Amazing Health Benefits of This Super-Seed
Written by Sayer Ji, Founder
Given the growing body of scientific support on its health benefits, sesame would be just as at home in a medicine cabinet as it would be a kitchen cupboard
Black Sesame Seed Reduces High Blood Pressure
Written by Case Adams, Naturopath
New research finds black sesame seed reduces hypertension and exert antioxidant effects. Do white sesame seeds have the same capacity?
Sesame May Eclipse Flaxseed As The Ultimate Healing Seed
Written by Sayer Ji, Founder
Whereas flaxseed has been enjoying its "superstar" status in the nutritional world for quite some time, sesame is still rarely appreciated for its true healing power. All that is about to change...

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.