Sesamol

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73 Diseases Researched for Sesamol
NameACCKFocus
Oxidative Stress2135Locked
Lipid Peroxidation1425Locked
Inflammation913Locked
Lipopolysaccharide-Induced Toxicity59Locked
Chemotherapy and Radiation Toxicity36Locked
Kidney Damage36Locked
Liver Damage36Locked
Chemically-Induced Liver Damage24Locked
Cognitive Decline/Dysfunction24Locked
Diabetes: Cognitive Dysfunction24Locked
Huntington Disease24Locked
Hyperlipidemia24Locked
Hypertension24Locked
Inflammatory Bowel Diseases24Locked
Memory Disorders24Locked
Brain: Oxidative Stress23Locked
Chemotherapy-Induced Toxicity: Doxorubicin23Locked
Colon Cancer23Locked
DNA damage23Locked
Radiation Induced Illness23Locked
Acetaminophen (Tylenol) Toxicity 12Locked
Aluminum Toxicity 12Locked
Arthritis12Locked
Atherosclerosis12Locked
Blood-Brain-Barrier Disorders12Locked
Brain Damage12Locked
Brain Inflammation 12Locked
Candida Albicans22Locked
Cataract12Locked
Cerebral Ischemia12Locked
Depression12Locked
Diabetic Neuropathies12Locked
Endothelial Dysfunction12Locked
Endotoxemia12Locked
Enterocolitis: Necrotiziing12Locked
Epilepsy12Locked
Gastric Ulcer12Locked
High Fat Diet12Locked
High Fructose Diet12Locked
Lung Infection12Locked
Lung Injury: Acute12Locked
Memory Impairment: Hormone Deficiency Induced12Locked
Menopausal Syndrome12Locked
Myocardial Infarction12Locked
Myocardial Infarction: Prevention12Locked
Neuropathic Pain12Locked
Obesity12Locked
Pancreatitis12Locked
Parkinson's Disease12Locked
Postmenopausal Disorders: Memory Impairment12Locked
Radiation Disaster Associated Toxicity12Locked
Respiratory Infections12Locked
Sepsis12Locked
Sinusoidal obstruction syndrome12Locked
Skin Cancer12Locked
Stroke: Ischemic12Locked
Triglycerides: Elevated12Locked
Wound Healing12Locked
Anemia11Locked
Candida Infection 11Locked
Chemotherapy-Induced Toxicity: Cyclophosphamide11Locked
Freckles11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Liver Cancer11Locked
Lung Cancer11Locked
Melasma11Locked
Osteoporosis11Locked
Progesterone: Low11Locked
Skin Diseases: Photo-Aging11Locked
Staphylococcus aureus infection11Locked
Streptococcus pneumoniae infection11Locked
Testicular Cancer11Locked
Tuberculosis: Drug Resistant11Locked
50 Pharmacological Actions Researched for Sesamol
NameACCKFocus
Antioxidants3561Locked
Neuroprotective Agents1223Locked
Anti-Inflammatory Agents1221Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor916Locked
Radioprotective611Locked
Apoptotic79Locked
Glutathione Upregulation 48Locked
Renoprotective48Locked
Gastroprotective36Locked
Hepatoprotective36Locked
Interleukin-1 beta downregulation46Locked
Cyclooxygenase 2 Inhibitors35Locked
Anti-Apoptotic24Locked
Cardioprotective24Locked
Chemopreventive24Locked
Chemoprotective Agents34Locked
Interleukin-6 Downregulation24Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor24Locked
NF-kappaB Inhibitor34Locked
Anti-Adipogenic23Locked
Nitric Oxide Inhibitor23Locked
Nrf2 activation23Locked
Prostaglandin PGE2 downregulation23Locked
Superoxide Dismutase Up-regulation23Locked
Anti-atherogenic12Locked
Anticarcinogenic Agents12Locked
Anticonvulsants12Locked
Antidepressive Agents12Locked
Antifungal Agents22Locked
Antihypertensive Agents12Locked
Bcl-2 protein down-regulation12Locked
Brain-derived neurotrophic factor modulator12Locked
Caspase-3 Inhibition12Locked
Catalase Up-Regulation12Locked
Chondroprotective12Locked
Cyclooxygenase Inhibitors12Locked
Enzyme Inhibitors12Locked
Malondialdehyde Down-regulation12Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor12Locked
Mitochondrial Superoxide Dismutase Upregulation12Locked
Anti-Bacterial Agents11Locked
Antimicrobial11Locked
Antineoplastic Agents11Locked
Antiproliferative 11Locked
Autophagy Inhibitors11Locked
Cell cycle arrest11Locked
Lipoxygenase Inhibitors11Locked
Secretagogue11Locked
Steroidogenesis11Locked
Tyrosinase Inhibition11Locked
Related Topics

Sesamol is a Sub of the following Topic

View the Evidence:
84 Abstracts with Sesamol Research

[+]

ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders.Jun 04, 2019

Pubmed Data : J Agric Food Chem. 2019 Jun 5 ;67(22):6190-6201. Epub 2019 May 28. PMID: 31117496
Article Published Date : Jun 04, 2019
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Gut-brain Axis
[+]

Both free and encapsulated sesamol demonstrated inhibition of tumor progression by inducing skin cell apoptosis via bcl-2/bax mediated pathway.Aug 18, 2016

Pubmed Data : Anticancer Agents Med Chem. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27539478
Article Published Date : Aug 18, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Elevated levels of cholesterol and triacylglycerol were significantly reversed by the sesamol.May 31, 2013

Pubmed Data : Lipids. 2013 Jun ;48(6):633-8. Epub 2013 Mar 17. PMID: 23504268
Article Published Date : May 31, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hyperlipidemia, Triglycerides: Elevated
Pharmacological Actions : Antioxidants
[+]

Oral supplementation of sesamol and sesamin beneficially modulated the inflammatory and oxidative stress markers.Feb 28, 2017

Pubmed Data : J Nutr Biochem. 2017 Mar ;41:151-157. Epub 2016 Dec 29. PMID: 28095362
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamin, Sesamol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Sesamin may prevent the development of atherosclerosis and inflammatory responsesSep 01, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Sep ;54(9):1340-50. PMID: 20306475
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Lignans, Sesamol
Diseases : Atherosclerosis, Endothelial Dysfunction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice.Mar 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Apr 1 ;9(4). Epub 2020 Apr 1. PMID: 32244835
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
[+]

Sesamol alleviates obesity-related hepatic steatosis via activating hepatic PKA pathway.Jan 25, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jan 26 ;12(2). Epub 2020 Jan 26. PMID: 31991934
Article Published Date : Jan 25, 2020
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hepatic Steatosis, High Fat Diet, Obesity
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Sesamol ameliorates diet-induced obesity in C57BL/6J mice.Dec 23, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Dec 24. Epub 2016 Dec 24. PMID: 28012248
Article Published Date : Dec 23, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Obesity
Pharmacological Actions : Anti-Adipogenic
Additional Keywords : Anti-Obesity Agents
[+]

Sesamol ameliorates high-fat and high-fructose induced cognitive defects.Jan 18, 2017

Pubmed Data : Food Funct. 2017 Jan 19. Epub 2017 Jan 19. PMID: 28102395
Article Published Date : Jan 18, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, High Fructose Diet, Memory Disorders
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol as a single prophylactic dose protects hematopoietic and gastrointestinal systems against γ-radiation-induced injury in mice.Dec 31, 2014

Pubmed Data : Free Radic Res. 2015 ;49(11):1344-61. Epub 2015 Aug 12. PMID: 26156438
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Radioprotective
[+]

Sesamol attenuates diabetes-associated cognitive decline in rats. Mar 01, 2008

Pubmed Data : Exp Brain Res. 2008 Mar ;185(3):411-20. Epub 2007 Oct 23. PMID: 17955223
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Diabetes: Cognitive Dysfunction, Oxidative Stress
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol attenuates diclofenac-induced acute gastric mucosal injury.Oct 01, 2008

Pubmed Data : Shock. 2008 Oct ;30(4):456-62. PMID: 18277948
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Gastric Ulcer, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase Inhibitors, Gastroprotective
Problem Substances : Diclofenac
Adverse Pharmacological Actions : Irritant
[+]

Sesamol attenuates experimentally induced Huntington-like changes in an animal model. Jan 01, 2009

Pubmed Data : J Asian Nat Prod Res. 2009 ;11(5):439-50. PMID: 19504387
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Huntington Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol attenuates experimentally induced myocardial infarction. Jan 01, 2011

Pubmed Data : Cell Physiol Biochem. 2011 ;27(3-4):273-80. Epub 2011 Apr 1. PMID: 21471716
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hypertension, Myocardial Infarction
Pharmacological Actions : Antioxidants, Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Sesamol attenuates lipopolysaccharide induced hypotension by regulating the circulating inflammatory response.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2015 ;14:948-57. Epub 2015 Aug 13. PMID: 26839527
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hypertension, Inflammation, Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Renoprotective
[+]

Sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome.Jun 17, 2011

Pubmed Data : Cell Biochem Biophys. 2011 Jun 17. Epub 2011 Jun 17. PMID: 21681587
Article Published Date : Jun 17, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Sinusoidal obstruction syndrome
Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.Mar 31, 2012

Pubmed Data : Hum Exp Toxicol. 2012 Apr ;31(4):397-404. Epub 2011 Nov 10. PMID: 22076497
Article Published Date : Mar 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Oxidative Stress, Pancreatitis
Pharmacological Actions : Antioxidants
[+]

Sesamol attenuates the renoinflammatory cascade in experimental model of diabetic nephropathy. Jul 22, 2009

Pubmed Data : J Agric Food Chem. 2009 Jul 22 ;57(14):6123-8. PMID: 19601660
Article Published Date : Jul 22, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Renoprotective
[+]

sesamol could be a potential neuroprotective agent during aging process due to its beneficial effects on liver-brain axis.Nov 13, 2018

Pubmed Data : Food Funct. 2018 Nov 14 ;9(11):5912-5924. PMID: 30375618
Article Published Date : Nov 13, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain: Oxidative Stress, Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Brain-derived neurotrophic factor modulator, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Gut-liver axis
[+]

Sesamol delays mortality and attenuates liver injury. May 01, 2006

Pubmed Data : Shock. 2006 May ;25(5):528-32. PMID: 16680019
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Liver Damage, Oxidative Stress
Pharmacological Actions : Hepatoprotective
[+]

Sesamol exerts ameliorative effects in the experimental model of epilepsy.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2014 Feb ;17(2):100-7. PMID: 24711892
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Epilepsy, Oxidative Stress
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Sesamol exhibits anti-depressant properties.Apr 01, 2011

Pubmed Data : Psychopharmacology (Berl). 2011 Apr ;214(4):819-28. Epub 2010 Nov 20. PMID: 21103863
Article Published Date : Apr 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Depression, Lipid Peroxidation
Pharmacological Actions : Antidepressive Agents, Catalase Up-Regulation, Glutathione Upregulation , Superoxide Dismutase Up-regulation
[+]

Sesamol has neuroprotective properties. Jun 01, 2011

Pubmed Data : Eur J Pharmacol. 2011 Jun 1 ;659(2-3):177-86. Epub 2011 Apr 2. PMID: 21463622
Article Published Date : Jun 01, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain Damage, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol has protective effects on mucosal in Inflammatory bowel disease.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2014 ;2014:802701. Epub 2014 Jan 30. PMID: 24616646
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Gastroprotective
[+]

Sesamol has radioprotective properties. Sep 01, 2009

Pubmed Data : Environ Toxicol Pharmacol. 2009 Sep ;28(2):192-7. Epub 2009 Apr 11. PMID: 21784002
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Oxidative Stress, Radiation Disaster Associated Toxicity
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2013 ;2013:934239. Epub 2013 Oct 21. PMID: 24228260
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Sesamol has strong potential to protect hematopoietic system by lowering radiation induced DNA damages.Aug 01, 2017

Pubmed Data : Environ Mol Mutagen. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28766757
Article Published Date : Aug 01, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Radioprotective
[+]

Sesamol has therapeutic value in ovariectomy-induced pathophysiological changes.Sep 26, 2012

Pubmed Data : Climacteric. 2012 Sep 27. Epub 2012 Sep 27. PMID: 23017032
Article Published Date : Sep 26, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Memory Impairment: Hormone Deficiency Induced, Menopausal Syndrome, Postmenopausal Disorders: Memory Impairment
Additional Keywords : Ovariectomy-Induced Changes
[+]

Sesamol has wound healing properties.Jan 27, 2011

Pubmed Data : J Ethnopharmacol. 2011 Jan 27 ;133(2):608-12. Epub 2010 Oct 28. PMID: 21035533
Article Published Date : Jan 27, 2011
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Wound Healing
Pharmacological Actions : Antioxidants
Additional Keywords : Science Confirms Tradition
Problem Substances : Dexamethasone
[+]

Sesamol improves blood-brain-barrier function in diabetic rats. Jul 01, 2009

Pubmed Data : Exp Brain Res. 2009 Jul ;197(1):23-34. Epub 2009 Jun 30. PMID: 19565232
Article Published Date : Jul 01, 2009
Study Type : Transgenic Animal Study
Additional Links
Substances : Sesamol
Diseases : Blood-Brain-Barrier Disorders, Diabetes: Cognitive Dysfunction, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Sesamol induced functional improvements during 5 days after middle cerebral artery occlusion.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Phys Ther Sci. 2015 Jun ;27(6):1771-3. Epub 2015 Jun 30. PMID: 26180317
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Stroke: Ischemic
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol induced mitochondrial protection in LPS-treated cells by a mechanism involving heme oxigenase-1.Dec 24, 2018

Pubmed Data : Chem Biol Interact. 2018 Dec 25 ;296:171-178. Epub 2018 Sep 24. PMID: 30261164
Article Published Date : Dec 24, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Lipopolysaccharide-Induced Toxicity, Mitochondrial Dysfunction
Pharmacological Actions : Anti-Apoptotic
[+]

Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2019 ;63. Epub 2019 Oct 23. PMID: 31692782
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Hepatoprotective, Hypolipidemic
[+]

Sesamol mitigated Lipopolysaccharide induced amyloidogenesis and memory impairment.Nov 14, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 15. Epub 2016 Nov 15. PMID: 27860258
Article Published Date : Nov 14, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Sesamol protects against acetaminophen-induced injury in animals.Jul 01, 2009

Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage, Lipid Peroxidation, Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Tylenol
Adverse Pharmacological Actions : Hepatotoxic, Oxidant
[+]

Sesamol protects against chemically-induced acute kidney injury in mice. Aug 01, 2008

Pubmed Data : Food Chem Toxicol. 2008 Aug ;46(8):2736-41. Epub 2008 Apr 29. PMID: 18539378
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Renoprotective
[+]

Sesamol protects against chemically-induced liver damage in rats. Nov 01, 1994

Pubmed Data : Yakugaku Zasshi. 1994 Nov ;114(11):901-10. PMID: 7853152
Article Published Date : Nov 01, 1994
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemically-Induced Liver Damage, Liver Damage
Pharmacological Actions : Hepatoprotective
[+]

Sesamol protects against chemically-induced oxidative renal injury in rats. Apr 01, 2009

Pubmed Data : Basic Clin Pharmacol Toxicol. 2009 Apr ;104(4):316-21. Epub 2009 Feb 27. PMID: 19281599
Article Published Date : Apr 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Kidney Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol protects against cognitive dysfunction and altered glutathione redox balance. Jul 01, 2010

Pubmed Data : Basic Clin Pharmacol Toxicol. 2010 Jul ;107(1):577-82. Epub 2010 Jan 25. PMID: 20102363
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Cognitive Decline/Dysfunction, Huntington Disease, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Sesamol protects against myocardial infarction. Jan 01, 2010

Pubmed Data : Redox Rep. 2010 ;15(1):36-42. PMID: 20196927
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Myocardial Infarction: Prevention
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Mitochondrial Superoxide Dismutase Upregulation
[+]

Sesamol protects against radiation-induced cytotoxicity in mice. Dec 10, 2006

Pubmed Data : Mutat Res. 2006 Dec 10 ;611(1-2):9-16. Epub 2006 Oct 11. PMID: 17045515
Article Published Date : Dec 10, 2006
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Radiation Induced Illness
Pharmacological Actions : Antioxidants, Radioprotective
[+]

Sesamol protects testis from ischemia-reperfusion injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:9043806. Epub 2020 Jun 17. PMID: 32655774
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Ischemia
Pharmacological Actions : Antioxidants
[+]

Sesamol reduces pulmonary inflammatory response and lung injury in endotoxemic rats.Jul 01, 2010

Pubmed Data : Food Chem Toxicol. 2010 Jul ;48(7):1821-6. Epub 2010 Apr 14. PMID: 20398721
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity, Lung Infection, Lung Injury: Acute, Respiratory Infections
Pharmacological Actions : NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol reduces total oxidant status, malondialdehyde levels and inhibits cataract formation.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk J Ophthalmol. 2017 Dec ;47(6):309-314. Epub 2017 Dec 27. PMID: 29326846
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Cataract
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Malondialdehyde Down-regulation
[+]

Sesamol supplementation may serve as potent adjuvant in the treatment of focal cerebral ischemia-reperfusion injury.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Jul ;14(1):841-847. Epub 2017 Jun 6. PMID: 28673008
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
[+]

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID: 24688218
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation
[+]

Sesamol suppresses neuropathic pain associated with diabetes.Oct 01, 2010

Pubmed Data : J Pain. 2010 Oct ;11(10):950-7. Epub 2010 Apr 24. PMID: 20418182
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Diabetic Neuropathies, Inflammation, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Caspase-3 Inhibition
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats.Mar 31, 2015

Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):327-36. PMID: 25829772
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Aluminum Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aluminum
[+]

The protective effects of sesamol in a neonatal rat model of necrotizing enterocolitis.Jul 28, 2018

Pubmed Data : J Matern Fetal Neonatal Med. 2018 Jul 29:1-11. Epub 2018 Jul 29. PMID: 30058400
Article Published Date : Jul 28, 2018
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Enterocolitis: Necrotiziing
Pharmacological Actions : Antioxidants, Gastroprotective
[+]

The results strongly suggest the radioprotective efficacy of sesamol in the haematopoietic system of mice.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mutagenesis. 2015 Sep ;30(5):651-61. Epub 2015 Apr 11. PMID: 25863274
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy and Radiation Toxicity, DNA damage
Pharmacological Actions : Radioprotective
[+]

These findings demonstrate the effects of sesamol in inducing Ucp1 and in increasing energy expenditure.May 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 May 18 ;12(5). Epub 2020 May 18. PMID: 32443555
Article Published Date : May 17, 2020
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : High Fat Diet, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

These findings indicated that the use of sesamol is feasible in the treatment of aging-related diseases.Feb 17, 2020

Pubmed Data : J Agric Food Chem. 2020 Feb 18. Epub 2020 Feb 18. PMID: 32067456
Article Published Date : Feb 17, 2020
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Aging, Brain Inflammation , Cognitive Decline/Dysfunction
Pharmacological Actions : Neuroprotective Agents
[+]

These results demonstrated that sesamol is a potent depigmenting agent in the animal model.Jul 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Jul 5 ;8(7). Epub 2019 Jul 5. PMID: 31284438
Article Published Date : Jul 04, 2019
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Hyperpigmentation, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Photoprotective
[+]

This concludes the mucosal protective effect of sesamol on colon due to its potent antioxidant actions.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Rep. 2013 ;65(3):658-65. PMID: 23950588
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Sep 30, 2013

Pubmed Data : Eur J Nutr. 2013 Oct ;52(7):1787-99. Epub 2012 Dec 27. PMID: 23269651
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Arthritis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study demonstrates the cellular mechanisms underlying the protective effects of sesamol and sesame oil against atherosclerosis.Jul 31, 2015

Pubmed Data : Eur J Nutr. 2015 Aug ;54(5):691-700. Epub 2014 Aug 1. PMID: 25081501
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Sesame Seed Oil , Sesamol
Diseases : Hyperlipidemia
Pharmacological Actions : Anti-atherogenic
[+]

This study demonstrates the comprehensive role of sesamol and naringenin in neuro and myoprotection.Dec 18, 2013

Pubmed Data : Neuroscience. 2013 Dec 19 ;254:379-94. Epub 2013 Sep 24. PMID: 24070629
Article Published Date : Dec 18, 2013
Study Type : Animal Study
Additional Links
Substances : Naringenin , Sesamol
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials.Mar 31, 2020

Pubmed Data : 3 Biotech. 2020 Apr ;10(4):149. Epub 2020 Mar 2. PMID: 32181111
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Statin-Induced Pathologies
Pharmacological Actions : Pancreato Protective Agents
Problem Substances : Simvastatin
[+]

High concentrations of sesamol induced the mitochondrial apoptosis pathway in human colon cancer HCT116 cells.Jul 31, 2016

Pubmed Data : Life Sci. 2016 Aug 1 ;158:46-56. Epub 2016 Jun 17. PMID: 27328416
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest
[+]

Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans.Apr 13, 2011

Pubmed Data : J Agric Food Chem. 2011 Apr 13 ;59(7):3214-9. Epub 2011 Mar 10. PMID: 21391595
Article Published Date : Apr 13, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesame Seeds, Sesamol
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Inhibition of lipoxygenase by sesamol corroborates its potential anti-inflammatory activity.Dec 31, 2016

Pubmed Data : Int J Biol Macromol. 2017 Jan ;94(Pt B):781-787. Epub 2016 Jun 15. PMID: 27316769
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Lipoxygenase Inhibitors
[+]

Mechanistic insights into the mode of action of the anti-candidal effect of sesamol.Aug 31, 2016

Pubmed Data : Microb Pathog. 2016 Sep ;98:140-8. Epub 2016 Jul 5. PMID: 27392701
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
[+]

Review: Sesamol has significant antioxidant properties. Jul 01, 2009

Pubmed Data : Med Chem. 2009 Jul ;5(4):367-71. PMID: 19689394
Article Published Date : Jul 01, 2009
Study Type : Review
Additional Links
Substances : Sesamol
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants
[+]

Role of L-type amino acid transporter 1 for the selective cytotoxicity of sesamol in human melanoma cells.Oct 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Oct 27 ;24(21). Epub 2019 Oct 27. PMID: 31717859
Article Published Date : Oct 26, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Melanoma
Pharmacological Actions : Antiproliferative
Additional Keywords : Selective Cytotoxicity
[+]

Sesame seed extract has antimicrobial properties. Jan 01, 2007

Pubmed Data : Afr J Tradit Complement Altern Med. 2007 ;4(4):427-33. Epub 2007 Jun 10. PMID: 20161911
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sesame Seeds, Sesamol
Diseases : Candida Infection , Staphylococcus aureus infection, Streptococcus pneumoniae infection
Pharmacological Actions : Antimicrobial
Additional Keywords : Science Confirms Tradition
[+]

Sesame seed oil does not contain significant quantities of sesamol. Sep 01, 1987

Pubmed Data : Contact Dermatitis. 1987 Sep ;17(3):133-5. PMID: 3677654
Article Published Date : Sep 01, 1987
Study Type : In Vitro Study
Additional Links
Substances : Lignans, Sesamol
[+]

Sesame seeds essential oil and sesamol modulate the pro-inflammatory function of macrophages and dendritic cells and promote Th2 response.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med J Islam Repub Iran. 2018 ;32:98. Epub 2018 Oct 10. PMID: 30788333
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sesame Seed Oil , Sesamol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamin and sesamol attenuate hydrogen peroxide-induced oxidative stress on human neuronal cells.Mar 29, 2019

Pubmed Data : Nutr Neurosci. 2019 Mar 30:1-12. Epub 2019 Mar 30. PMID: 30929586
Article Published Date : Mar 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sesamin, Sesamol
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Neuroprotective Agents
[+]

Sesamol ameliorated inflammatory and oxidative damage.Jul 31, 2015

Pubmed Data : Inflamm Res. 2015 Aug ;64(8):577-88. Epub 2015 Jun 10. PMID: 26059394
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Nrf2 activation, Prostaglandin PGE2 downregulation
[+]

Sesamol down-regulates the lipopolysaccharide-induced inflammatory response.Oct 01, 2010

Pubmed Data : Innate Immun. 2010 Oct ;16(5):333-9. Epub 2009 Nov 25. PMID: 19939906
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Sesamol exhibited high antioxidant and anti-tyrosinase activity Feb 28, 2014

Pubmed Data : J Cosmet Sci. 2014 Mar-Apr;65(2):69-79. PMID: 24797023
Article Published Date : Feb 28, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Tyrosinase Inhibition
[+]

Sesamol exhibits potent antimycobacterial activity.Jul 18, 2017

Pubmed Data : J Glob Antimicrob Resist. 2017 Jul 19 ;10:228-237. Epub 2017 Jul 19. PMID: 28735047
Article Published Date : Jul 18, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Tuberculosis: Drug Resistant
Pharmacological Actions : Anti-Bacterial Agents
Additional Keywords : Biofilm, Natural Substance/Drug Synergy
[+]

Sesamol has anti-adipogenic effects of on human mesenchymal stem cells.Dec 31, 2015

Pubmed Data : Biochem Biophys Res Commun. 2016 Jan 1 ;469(1):49-54. Epub 2015 Nov 23. PMID: 26616060
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Anemia, Osteoporosis
Pharmacological Actions : Anti-Adipogenic, Antioxidants
Additional Keywords : Mesenchymal Stem Cells
[+]

Sesamol induces apoptosis through both pathways in human lung adenocarcinoma (SK-LU-1) cells.Jul 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Jul 25 ;254:109-16. Epub 2016 Jun 4. PMID: 27270451
Article Published Date : Jul 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic
[+]

Sesamol induces cell death and up-regulates progesterone production in mouse testical tumor cells.Sep 06, 2011

Pubmed Data : J Agric Food Chem. 2011 Sep 6. Epub 2011 Sep 6. PMID: 21863802
Article Published Date : Sep 06, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Progesterone: Low, Testicular Cancer
Pharmacological Actions : Apoptotic, Secretagogue, Steroidogenesis
[+]

Sesamol is a powerful radioprotective substance.Sep 07, 2011

Pubmed Data : Radiat Res. 2011 Sep 7. Epub 2011 Sep 7. PMID: 21899433
Article Published Date : Sep 07, 2011
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Radiation Induced Illness
Pharmacological Actions : Radioprotective
[+]

Sesamol is an effectual antifungal agent that could be competently employed in treating Candida infections.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pathog. 2014 ;2014:895193. Epub 2014 Dec 9. PMID: 25574401
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Candida Albicans
Pharmacological Actions : Antifungal Agents
[+]

Sesamol prevents UVB-induced damage to cultured skin cells. Dec 01, 2010

Pubmed Data : Arch Dermatol Res. 2010 Dec ;302(10):733-44. Epub 2010 Aug 10. PMID: 20697726
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : DNA damage, Lipid Peroxidation, Oxidative Stress, Skin Diseases: Photo-Aging
Pharmacological Actions : Antioxidants, Apoptotic, Superoxide Dismutase Up-regulation
[+]

Sesamol represents a new skin-whitening agent for use in cosmetics.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Dermatol. 2015 Oct ;24(10):761-6. Epub 2015 Jul 14. PMID: 26010596
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Freckles, Melasma
Pharmacological Actions : Antioxidants
[+]

Sesamol: a powerful functional food ingredient from sesame oil for cardioprotection.Feb 09, 2020

Pubmed Data : Food Funct. 2020 Feb 10. Epub 2020 Feb 10. PMID: 32037412
Article Published Date : Feb 09, 2020
Study Type : Review
Additional Links
Substances : Sesamol
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
[+]

There is ample evidence suggesting that sesamol possesses potent anti-cancer properties in vitro and in vivo.Jul 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Jul 15 ;855:75-89. Epub 2019 May 4. PMID: 31063773
Article Published Date : Jul 14, 2019
Study Type : Review
Additional Links
Substances : Sesamol
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These data suggest that mitochondria play an essential role in sesamol-induced HepG2 cells death.Apr 03, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Apr 4 ;7:45728. Epub 2017 Apr 4. PMID: 28374807
Article Published Date : Apr 03, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Inhibitors
[+]

This reflects the significance of sesamol in ameliorating the deleterious effects associated with cancer chemotherapy.Jun 30, 2013

Pubmed Data : J Pharm Pharmacol. 2013 Jul ;65(7):1083-93. Epub 2013 Apr 22. PMID: 23738736
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Additional Keywords : Drug: Doxorubicin
[+]

This study clearly demonstrated the potentiality of sesamol against cyclophosphamide induced organ toxicity and oxidative stress.Dec 31, 2013

Pubmed Data : Anticancer Agents Med Chem. 2014 ;14(7):975-83. PMID: 24372526
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents

Copyright: baibaz / 123RF Stock Photo

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