Theaflavins

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16 Diseases Researched for Theaflavins
NameACCKFocus
Liver Cancer23Locked
Cardiovascular Diseases12Locked
Herpes Simplex Virus Type 122Locked
Liver Cancer: Prevention12Locked
Ovarian Cancer22Locked
Periodontal Diseases22Locked
Tongue Cancer12Locked
Cancers: All11Locked
Cervical Cancer11Locked
HIV Infections11Locked
Herpes Simplex Virus Type 211Locked
Human Papillomavirus (HPV)11Locked
Obesity11Locked
Parkinson's Disease11Locked
Porphyromonas gingivalis11Locked
Simian virus 40 (SV40)11Locked
28 Pharmacological Actions Researched for Theaflavins
NameACCKFocus
Anticarcinogenic Agents24Locked
Apoptotic44Locked
Chemopreventive24Locked
Antiviral Agents33Locked
Anti-Inflammatory Agents22Locked
Antiproliferative 22Locked
Cardioprotective12Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor22Locked
Vascular Endothelial Growth Factor Inhibitors22Locked
Wnt/β-catenin signaling pathway modulation12Locked
Anti-Angiogenic11Locked
Anti-Bacterial Agents11Locked
Anti-Infective Agents11Locked
Anti-metastatic11Locked
Antioxidants11Locked
Chemosensitizer11Locked
Cyclooxygenase 2 Inhibitors11Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor11Locked
Interleukin-1 beta downregulation11Locked
Interleukin-6 Downregulation11Locked
Interleukin-8 downregulation11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
Matrix metalloproteinase-3 (MMP-3) inhibitor11Locked
Matrix metalloproteinase-8 (MMP-8) inhibitor11Locked
NF-kappaB Inhibitor11Locked
Neuritogenic11Locked
Neuroprotective Agents11Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor11Locked

View the Evidence:
38 Abstracts with Theaflavins Research

[+]

A single dose of theaflavin rich fraction enhanced energy expenditure accompanied by an increase in expression of metabolic genes.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(9):e0137809. Epub 2015 Sep 16. PMID: 26375960
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective
Additional Keywords : Risk Reduction
[+]

Anxiolytic effects of theaflavins via dopaminergic activation in the frontal cortex.May 31, 2019

Pubmed Data : Biosci Biotechnol Biochem. 2019 Jun ;83(6):1157-1162. Epub 2019 Feb 26. PMID: 30806570
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Anxiety
Pharmacological Actions : Anti-Anxiety Agents, Antioxidants
[+]

Epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways.Aug 20, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug 21. Epub 2015 Aug 21. PMID: 26386739
Article Published Date : Aug 20, 2015
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Liver Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Wnt/β-catenin signaling pathway modulation
[+]

Tea polyphenols Epigallocatechin gallate and Theaflavin restrict tongue and liver carcinogenesis.May 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Jun 1 ;300:34-46. Epub 2016 Apr 4. PMID: 27058323
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Liver Cancer, Tongue Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive
[+]

Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:1609-1619. Epub 2018 Jun 12. PMID: 29928110
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Brain Inflammation , Cerebral Hemorrhage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor
[+]

Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease.Aug 30, 2012

Pubmed Data : Neuroscience. 2012 Aug 30 ;218:257-67. Epub 2012 May 23. PMID: 22634505
Article Published Date : Aug 30, 2012
Study Type : Animal Study
Additional Links
Substances : Catechin , Theaflavins
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease.Jan 18, 2012

Pubmed Data : Brain Res. 2012 Jan 18 ;1433:104-13. Epub 2011 Nov 13. PMID: 22138428
Article Published Date : Jan 18, 2012
Study Type : Animal Study
Additional Links
Substances : Black Tea, Black Tea Theaflavins, Catechin , Polyphenols, Tea, Theaflavins
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

Theaflavins have therapeutic potential in the treatment of periodontal disease.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Periodontal Res. 2018 Dec ;53(6):1009-1019. Epub 2018 Aug 30. PMID: 30159985
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

These results suggest that theaflavins can suppress neural inflammation and prevent the symptoms of inflammation-related brain disorders.Jan 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Jan 28 ;24(3). Epub 2019 Jan 28. PMID: 30696093
Article Published Date : Jan 27, 2019
Study Type : Animal Study
Additional Links
Substances : Theaflavins
Diseases : Brain Inflammation , Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents
[+]

Theaflavins suppress the growth and metastasis of human hepatocellular carcinoma.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2016 ;9:4265-75. Epub 2016 Jul 14. PMID: 27478384
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Advances on natural polyphenols as anticancer agents for skin cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res. 2020 01 ;151:104584. Epub 2019 Dec 3. PMID: 31809853
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Punicalagin, Quercetin, Resveratrol, Theaflavins
Diseases : Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Chemopreventive
[+]

All four theaflavin derivatives tested reduced the viability of ovarian cancer cells.Jan 31, 2016

Pubmed Data : Anticancer Res. 2016 Feb ;36(2):643-51. PMID: 26851019
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Vascular Endothelial Growth Factor Inhibitors
[+]

Black tea extract and theaflavins exerts antibacterial activity against major periodontopathogens.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(11):e0143158. Epub 2015 Nov 18. PMID: 26581041
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Periodontal Diseases
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-8 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Black tea extract has the potential to be developed as a safe, therapeutic antiviral agent to prevent the spread of HSV-1.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2013 ;13:139. Epub 2013 Jun 18. PMID: 23777309
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Anti-Infective Agents, Antiviral Agents
Additional Keywords : Plant Extracts
[+]

Black tea polyphenol theaflavin as promising antioxidant and potential copper chelator.Feb 21, 2020

Pubmed Data : J Sci Food Agric. 2020 Feb 22. Epub 2020 Feb 22. PMID: 32086808
Article Published Date : Feb 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Copper Toxicity
Pharmacological Actions : Metal Chelation: Copper
[+]

Black tea theaflavins represent promising multifunctional therapeutic agents for prevention and treatment of periodontal disease.Aug 22, 2016

Pubmed Data : J Periodontal Res. 2016 Aug 23. Epub 2016 Aug 23. PMID: 27549582
Article Published Date : Aug 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Periodontal Diseases, Porphyromonas gingivalis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-8 (MMP-8) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG and theaflavins chemosensitize the cervical cancer cells to cisplatin induced growth inhibition and apoptosis.Jul 18, 2013

Pubmed Data : Life Sci. 2013 Jul 19 ;93(1):7-16. Epub 2013 Feb 9. PMID: 23399702
Article Published Date : Jul 18, 2013
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′-digallate.Dec 31, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2005 06 ;2(2):209-215. Epub 2005 Apr 7. PMID: 15937562
Article Published Date : Dec 31, 2004
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Coronaviridae Infections, Severe Acute Respiratory Syndrome
Pharmacological Actions : Antiviral Agents
[+]

Inhibitory effect of black tea (Camellia sinensis) theaflavins and thearubigins against HCT 116 colon cancer cells and HT 460 lung cancer cells.Apr 30, 2019

Pubmed Data : J Food Biochem. 2019 May ;43(5):e12822. Epub 2019 Mar 4. PMID: 31353529
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Colon Cancer, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Inhibitory effect of black tea pigments, theaflavin 3/3'-gallate against cisplatin-resistant ovarian cancer cells.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2017 Nov ;51(5):1508-1520. Epub 2017 Oct 3. PMID: 29048667
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest
[+]

Mechanism for antibacterial action of epigallocatechin gallate and theaflavin-3,3'-digallate on Clostridium perfringens.Jan 31, 2019

Pubmed Data : J Appl Microbiol. 2019 Feb ;126(2):633-640. Epub 2018 Nov 23. PMID: 30353941
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Clostridium Infections
Pharmacological Actions : Anti-Bacterial Agents
[+]

Natural polyphenols have potential in the prevention of sexually transmitted viral infections.Nov 03, 2015

Pubmed Data : Drug Discov Today. 2015 Nov 4. Epub 2015 Nov 4. PMID: 26546859
Article Published Date : Nov 03, 2015
Study Type : Review
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Genistein, Polyphenols, Resveratrol, Theaflavins
Diseases : Herpes Simplex Virus Type 2, HIV Infections, Human Papillomavirus (HPV)
Pharmacological Actions : Antiviral Agents
[+]

Pre-treated theaflavin-3,3'-digallate has a higher inhibitory effect on the HCT116 cell line.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Nutr Res. 2017 ;61(1):1400340. Epub 2017 Nov 15. PMID: 29200992
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Structure-activity relationship analysis on antioxidant and anticancer actions of theaflavins on human colon cancer cells.Nov 25, 2018

Pubmed Data : J Agric Food Chem. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30474978
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Colon Cancer
Pharmacological Actions : Antioxidants, Chemotherapeutic
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Synergistic effect of black tea polyphenol, theaflavin-3,3'-digallate with cisplatin against cisplatin resistant human ovarian cancer cells.Jun 30, 2018

Pubmed Data : J Funct Foods. 2018 Jul ;46:1-11. Epub 2018 Apr 26. PMID: 30364631
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Cancers: Drug Resistant, Ovarian Cancer
Pharmacological Actions : Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Theaflavin and epigallocatechin-3-gallate synergistically induce apoptosis in HeLa cells.Nov 01, 2018

Pubmed Data : J Cell Biochem. 2018 Nov 2. Epub 2018 Nov 2. PMID: 30390323
Article Published Date : Nov 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Theaflavins
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic
Additional Keywords : Natural Substance Synergy
[+]

Theaflavin digallate has potential to be a promising natural and affordable remedy against herpes simplex viral infections.May 31, 2015

Pubmed Data : Antiviral Res. 2015 Jun ;118:56-67. Epub 2015 Mar 27. PMID: 25818500
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Herpes Simplex Virus Type 1
Pharmacological Actions : Antiviral Agents
Additional Keywords : Dose Response
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Theaflavin-3, 3'-digallate might serve as a potential anti-angiogenic agent for cancer treatment.Nov 19, 2015

Pubmed Data : Int J Oncol. 2015 Nov 20. Epub 2015 Nov 20. PMID: 26648098
Article Published Date : Nov 19, 2015
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Polyphenols, Theaflavins
Diseases : Ovarian Cancer
Pharmacological Actions : Anti-Angiogenic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Theaflavin-3,3'-digallate might be used as an adjuvant to potentiate the inhibitory effect of cisplatin against advanced ovarian cancer.Jan 01, 2018

Pubmed Data : Int J Mol Sci. 2018 Jan 2 ;19(1). Epub 2018 Jan 2. PMID: 29301278
Article Published Date : Jan 01, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Ovarian Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Theaflavins are promising functional food ingredients and medicines for improving insulin resistance-related disorders.Dec 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Dec 19 ;23(12). Epub 2018 Dec 19. PMID: 30572687
Article Published Date : Dec 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Insulin Disorders, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Theaflavins attenuate ethanol‑induced oxidative stress and cell apoptosis in gastric mucosa epithelial cells.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Oct ;18(4):3791-3799. Epub 2018 Aug 3. PMID: 30106096
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Gastroprotective
[+]

Theaflavins from black tea exhibit antiviral activity against bovine rotavirus and bovine coronavirus infections.Oct 01, 1998

Pubmed Data : Vet Microbiol. 1998 Oct ;63(2-4):147-57. PMID: 9850995
Article Published Date : Oct 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Black Tea Theaflavins, Catechin , Tea, Theaflavins
Diseases : Coronavirus Disease, Coronavirus Infection
Pharmacological Actions : Antiviral Agents
[+]

Theaflavins from black tea selectively inhibit SV40-transformed cancer cells.Nov 15, 2000

Pubmed Data : Cancer Res. 2000 Nov 15;60(22):6465-71. PMID: 11103814
Article Published Date : Nov 15, 2000
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Catechin , Theaflavins
Diseases : Cancers: All, Simian virus 40 (SV40)
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Selective Cytotoxicity
[+]

Theaflavins inhibit entry of hepatitis C virus in cell culture.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0198226. Epub 2018 Nov 28. PMID: 30485282
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Hepatitis C
Pharmacological Actions : Antiviral Agents
[+]

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Feb ;19(2):821-830. Epub 2018 Dec 12. PMID: 30569095
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Theaflavins
Diseases : Cartilage Diseases
[+]

These data provide a putative mechanism to explain the anti-obesity effects of tea. Jan 31, 2017

Pubmed Data : Food Chem. 2017 Feb 1 ;216:296-300. Epub 2016 Aug 18. PMID: 27596423
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Black Tea, Theaflavins
Diseases : Obesity
Additional Keywords : Anti-Obesity Agents
[+]

These studied flavonoids significantly enhances doxorubicin-mediated cell death.Nov 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2018 Nov 26 ;18(1):1168. Epub 2018 Nov 26. PMID: 30477461
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Quercetin, Rutin, Theaflavins
Diseases : Cancers: Multi-Drug Resistant
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Wnt/β-catenin signaling pathway modulation
[+]

This review collates the current knowledge of tea polyphenols and puts into perspective their potential to be considered as nutraceuticals that target various pathologies in PD.Dec 31, 2014

Pubmed Data : Adv Exp Med Biol. 2015;863:117-137. PMID: 26092629
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Black Tea, EGCG (Epigallocatechin gallate), Green Tea, Polyphenols, Tea, Theaflavins
Diseases : Parkinson's Disease
Pharmacological Actions : Neuritogenic, Neuroprotective Agents

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