Urolithin A

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8 Diseases Researched for Urolithin A
NameACCKFocus
Dysbiosis110Locked
Cachexia12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
Colon Cancer12Locked
Inflammation12Locked
Endometrial Cancer11Locked
Liver Cancer11Locked
Prostate Cancer11Locked
13 Pharmacological Actions Researched for Urolithin A
NameACCKFocus
Gastrointestinal Agents110Locked
Anti-Inflammatory Agents47Locked
Cell cycle arrest23Locked
Antiproliferative 22Locked
Chemopreventive22Locked
Chemoprotective Agents12Locked
Chemosensitizer12Locked
Antioxidants11Locked
Apoptotic11Locked
P21 Activation11Locked
Superoxide Dismutase Up-regulation11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
33 Abstracts with Urolithin A Research

[+]

In UA producers, the genera Butyrivibrio, Enterobacter, Escherichia, Lactobacillus, Prevotella, Serratia and Veillonella were increased and Collinsella decreased significantly at week 4 compared to baseline.Jul 19, 2015

Pubmed Data : Food Funct. 2015 Jul 20. Epub 2015 Jul 20. PMID: 26189645
Article Published Date : Jul 19, 2015
Study Type : Human Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Dysbiosis
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Metabolites, Microbiota
[+]

Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

Pubmed Data : Food Funct. 2015 May ;6(5):1460-9. PMID: 25857357
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Cell cycle arrest, Chemosensitizer
Additional Keywords : Drug: 5-flourouracil, Metabolites, Microbiota
[+]

Emblic leafflower (Phyllanthus emblica L.) fruits ameliorate vascular smooth muscle cell dysfunction in hyperglycemia.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:8478943. Epub 2018 Mar 6. PMID: 29692859
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Amla Fruit, Urolithin A
Diseases : Diabetic Complications, Hyperglycemia
Pharmacological Actions : Cytoprotective
[+]

Neuroprotective effects of pomegranate juice against Parkinson's disease.Dec 26, 2019

Pubmed Data : Int J Mol Sci. 2019 Dec 27 ;21(1). Epub 2019 Dec 27. PMID: 31892167
Article Published Date : Dec 26, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin.Mar 24, 2020

Pubmed Data : J Ethnopharmacol. 2020 Mar 25 ;250:112479. Epub 2019 Dec 14. PMID: 31846746
Article Published Date : Mar 24, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Diabetes Mellitus: Type 2, High Fat Diet
Pharmacological Actions : Pancreato Protective Agents
[+]

Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses in rats fed a high-fat diet.Nov 12, 2019

Pubmed Data : Food Funct. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31720661
Article Published Date : Nov 12, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Pomegranate Polyphenols, Punicalagin, Urolithin A
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Supplementation with a punicalagin-rich pomegranate extract may protect skeletal muscle against an acute inflammation.Nov 01, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 2. Epub 2016 Aug 2. PMID: 27804206
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Punicalagin, Urolithin A
Diseases : Cachexia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The protective effect of urolithin a on cisplatin-induced nephrotoxicity.Jun 30, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jul ;129:108-114. Epub 2019 Apr 20. PMID: 31014901
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Renoprotective
[+]

Urolithin A attenuates memory impairment and neuroinflammation.Mar 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2019 Mar 14 ;16(1):62. Epub 2019 Mar 14. PMID: 30871577
Article Published Date : Mar 13, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Urolithin A downregulates androgen receptor activation and suppresses growth of prostate cancer.Sep 30, 2018

Pubmed Data : Mol Carcinog. 2018 Oct ;57(10):1332-1341. Epub 2018 Aug 1. PMID: 30069922
Article Published Date : Sep 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative
[+]

Urolithin A improves insulin sensitivity through augmentation of mitochondrial function and biogenesis.Mar 31, 2019

Pubmed Data : Obesity (Silver Spring). 2019 Apr ;27(4):612-620. Epub 2019 Feb 15. PMID: 30768775
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Urolithin A may be a useful therapeutic agent for the treatment of Intervertebral disc degeneration.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1043. Epub 2018 Sep 18. PMID: 30283339
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A may be adopted as a new therapeutic agent for the treatment of osteoarthritis.Sep 08, 2019

Pubmed Data : Food Funct. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31497826
Article Published Date : Sep 08, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A mitigates cisplatin-induced nephrotoxicity in rats.Aug 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2017 Aug 7. Epub 2017 Aug 7. PMID: 28784820
Article Published Date : Aug 06, 2017
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Urolithin A protected against ischemic neuronal injury by reinforcing autophagy rather than mitophagy.Apr 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : CNS Neurosci Ther. 2019 Apr 11. Epub 2019 Apr 11. PMID: 30972969
Article Published Date : Apr 10, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Cerebral Ischemia
Pharmacological Actions : Autophagy Up-regulation, Neuroprotective Agents
[+]

Urolithin A shows anti-atherosclerotic activity.May 31, 2018

Pubmed Data : Pharmacol Rep. 2018 Jun ;70(3):519-524. Epub 2017 May 4. PMID: 29660655
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Atherosclerosis
Pharmacological Actions : Hypolipidemic
[+]

Urolithin A significantly attenuated the histopathological hallmarks of cisplatin-induced acute kidney injury and reduced mortality by 63%.Sep 17, 2019

Pubmed Data : Am J Physiol Renal Physiol. 2019 Sep 18. Epub 2019 Sep 18. PMID: 31532243
Article Published Date : Sep 17, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Chemotherapeutic, Renoprotective
[+]

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration.Feb 23, 2020

Pubmed Data : Free Radic Biol Med. 2020 Feb 24 ;150:109-119. Epub 2020 Feb 24. PMID: 32105828
Article Published Date : Feb 23, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic
[+]

An overview of natural plant products in the treatment of hepatocellular carcinoma.Jun 02, 2018

Pubmed Data : Anticancer Agents Med Chem. 2018 Jun 3. Epub 2018 Jun 3. PMID: 29866017
Article Published Date : Jun 02, 2018
Study Type : Review
Additional Links
Substances : Caffeine, Curcumin, Emodin, Lycopene, Phloretin, Quercetin, Resveratrol, Silibinin, Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

Neuroprotective effects of urolithin A on H2O2-induced oxidative stress-mediated apoptosis in SK-N-MC cells.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2020 Feb ;14(1):3-11. Epub 2019 Oct 18. PMID: 32042368
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

The metabolite urolithin-A ameliorates oxidative stress in neuro-2a cells.Feb 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Feb 21 ;9(2). Epub 2020 Feb 21. PMID: 32098107
Article Published Date : Feb 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

The use of dietary urolithin A in cancer prevention or as adjuvant therapy is promising.Jan 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2020 Jan 24:e1900390. Epub 2020 Jan 24. PMID: 31976617
Article Published Date : Jan 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic
[+]

These findings indicated that urolithin A exerted a antiproliferative effect in liver cancer cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2018 ;51(7):e7220. Epub 2018 May 7. PMID: 29742265
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
[+]

These results indicate a potential role of urolithin A as a chemopreventive agent for prostate cancer.May 11, 2015

Pubmed Data : Eur J Nutr. 2015 May 12. Epub 2015 May 12. PMID: 25962506
Article Published Date : May 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A , Walnut
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, P21 Activation
[+]

These results suggest that dietary consumption of urolithin A could induce autophagy and inhibit human colorectal cancer cell metastasis.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Carcinog. 2018 Feb ;57(2):193-200. Epub 2017 Nov 26. PMID: 28976622
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Autophagy Up-regulation
[+]

This explains from a molecular perspective the beneficial effects and traditional use of pomegranate in the prevention of metabolic-associated disorders.Mar 27, 2018

Pubmed Data : J Ethnopharmacol. 2018 Mar 28 ;220:67-74. Epub 2018 Mar 28. PMID: 29604377
Article Published Date : Mar 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Diabetic Complications
Pharmacological Actions : Alpha-glucosidase inhibitor
[+]

Urolithin A could inhibit cell proliferation and reduce oxidative stress status in liver cancer. Jul 31, 2015

Pubmed Data : Toxicol In Vitro. 2015 Aug ;29(5):1107-15. Epub 2015 Apr 21. PMID: 25910917
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells.Mar 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2019 Mar 12 ;40(1):93-101. PMID: 30418550
Article Published Date : Mar 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner.Jun 07, 2019

Pubmed Data : Eur J Nutr. 2019 Jun 8. Epub 2019 Jun 8. PMID: 31177307
Article Published Date : Jun 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Urolithin A may exert neuroprotective effects and may aid in preventing D-gal-induced brain aging.Sep 30, 2019

Pubmed Data : Neurotherapeutics. 2019 Oct ;16(4):1269-1282. PMID: 31420820
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Urolithin A modulates ERα-dependent gene expression and thereby inhibiting endometrial cancer proliferation.Jun 24, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27342949
Article Published Date : Jun 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Endometrial Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Gene Expression Regulation
[+]

Urolithin A showed a strong potential of anti-aging.Sep 13, 2018

Pubmed Data : Rejuvenation Res. 2018 Sep 14. Epub 2018 Sep 14. PMID: 30215291
Article Published Date : Sep 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Aging Skin
Pharmacological Actions : Anti-Apoptotic, Matrix metalloproteinase-1 (MMP-1) inhibitor, Nrf2 activation
[+]

Urolithins A and B attenuated LPS-induced inflammation in BV2 microglia.Jan 23, 2018

Pubmed Data : J Agric Food Chem. 2018 Jan 24 ;66(3):571-580. Epub 2018 Jan 16. PMID: 29336147
Article Published Date : Jan 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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