Urolithin A

Views 274
Jump to
Abstracts Focused Research Topics
Your Token Count0

Sign in to Purchase/Download Documents

Sign in / Register

Focus Your Research

Click any topic below to filter + focus research
8 Diseases Researched for Urolithin A
NameACCKFocus
Dysbiosis110Locked
Cachexia12Locked
Chemotherapy-Induced Toxicity: Cisplatin12Locked
Colon Cancer12Locked
Inflammation12Locked
Endometrial Cancer11Locked
Liver Cancer11Locked
Prostate Cancer11Locked
13 Pharmacological Actions Researched for Urolithin A
NameACCKFocus
Gastrointestinal Agents110Locked
Anti-Inflammatory Agents47Locked
Cell cycle arrest23Locked
Antiproliferative 22Locked
Chemopreventive22Locked
Chemoprotective Agents12Locked
Chemosensitizer12Locked
Antioxidants11Locked
Apoptotic11Locked
P21 Activation11Locked
Superoxide Dismutase Up-regulation11Locked
Tumor Suppressor Protein p53 Upregulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
42 Abstracts with Urolithin A Research

[+]

In UA producers, the genera Butyrivibrio, Enterobacter, Escherichia, Lactobacillus, Prevotella, Serratia and Veillonella were increased and Collinsella decreased significantly at week 4 compared to baseline.Jul 19, 2015

Pubmed Data : Food Funct. 2015 Jul 20. Epub 2015 Jul 20. PMID: 26189645
Article Published Date : Jul 19, 2015
Study Type : Human Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Dysbiosis
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Metabolites, Microbiota
[+]

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Biol. 2020 03 ;18(3):e3000688. Epub 2020 Mar 27. PMID: 32218572
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Fatty Liver, Insulin Resistance, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

Pubmed Data : Food Funct. 2015 May ;6(5):1460-9. PMID: 25857357
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Cell cycle arrest, Chemosensitizer
Additional Keywords : Drug: 5-flourouracil, Metabolites, Microbiota
[+]

Ellagic acid and its microbial metabolite urolithin A alleviate diet-induced insulin resistance in mice.Aug 10, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Aug 11:e2000091. Epub 2020 Aug 11. PMID: 32783299
Article Published Date : Aug 10, 2020
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
[+]

Emblic leafflower (Phyllanthus emblica L.) fruits ameliorate vascular smooth muscle cell dysfunction in hyperglycemia.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:8478943. Epub 2018 Mar 6. PMID: 29692859
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Amla Fruit, Urolithin A
Diseases : Diabetic Complications, Hyperglycemia
Pharmacological Actions : Cytoprotective
[+]

Neuroprotective effects of pomegranate juice against Parkinson's disease.Dec 26, 2019

Pubmed Data : Int J Mol Sci. 2019 Dec 27 ;21(1). Epub 2019 Dec 27. PMID: 31892167
Article Published Date : Dec 26, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin.Mar 24, 2020

Pubmed Data : J Ethnopharmacol. 2020 Mar 25 ;250:112479. Epub 2019 Dec 14. PMID: 31846746
Article Published Date : Mar 24, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Diabetes Mellitus: Type 2, High Fat Diet
Pharmacological Actions : Pancreato Protective Agents
[+]

Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses in rats fed a high-fat diet.Nov 12, 2019

Pubmed Data : Food Funct. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31720661
Article Published Date : Nov 12, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Pomegranate Polyphenols, Punicalagin, Urolithin A
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Supplementation with a punicalagin-rich pomegranate extract may protect skeletal muscle against an acute inflammation.Nov 01, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 2. Epub 2016 Aug 2. PMID: 27804206
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Punicalagin, Urolithin A
Diseases : Cachexia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The protective effect of urolithin a on cisplatin-induced nephrotoxicity.Jun 30, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jul ;129:108-114. Epub 2019 Apr 20. PMID: 31014901
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Renoprotective
[+]

Urolithin A attenuates memory impairment and neuroinflammation.Mar 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2019 Mar 14 ;16(1):62. Epub 2019 Mar 14. PMID: 30871577
Article Published Date : Mar 13, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Urolithin A downregulates androgen receptor activation and suppresses growth of prostate cancer.Sep 30, 2018

Pubmed Data : Mol Carcinog. 2018 Oct ;57(10):1332-1341. Epub 2018 Aug 1. PMID: 30069922
Article Published Date : Sep 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative
[+]

Urolithin A improves insulin sensitivity through augmentation of mitochondrial function and biogenesis.Mar 31, 2019

Pubmed Data : Obesity (Silver Spring). 2019 Apr ;27(4):612-620. Epub 2019 Feb 15. PMID: 30768775
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Urolithin A is a promising candidate for the development of therapies to prevent diabetes mellitus-associated Alzheimer's disease pathogenesis.Jul 22, 2020

Pubmed Data : Cell Death Differ. 2020 Jul 23. Epub 2020 Jul 23. PMID: 32704090
Article Published Date : Jul 22, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Alzheimer's Disease, Hyperglycemia
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Urolithin A may be a useful therapeutic agent for the treatment of Intervertebral disc degeneration.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1043. Epub 2018 Sep 18. PMID: 30283339
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A may be adopted as a new therapeutic agent for the treatment of osteoarthritis.Sep 08, 2019

Pubmed Data : Food Funct. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31497826
Article Published Date : Sep 08, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A mitigates cisplatin-induced nephrotoxicity in rats.Aug 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2017 Aug 7. Epub 2017 Aug 7. PMID: 28784820
Article Published Date : Aug 06, 2017
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Urolithin A protected against ischemic neuronal injury by reinforcing autophagy rather than mitophagy.Apr 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : CNS Neurosci Ther. 2019 Apr 11. Epub 2019 Apr 11. PMID: 30972969
Article Published Date : Apr 10, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Cerebral Ischemia
Pharmacological Actions : Autophagy Up-regulation, Neuroprotective Agents
[+]

Urolithin A shows anti-atherosclerotic activity.May 31, 2018

Pubmed Data : Pharmacol Rep. 2018 Jun ;70(3):519-524. Epub 2017 May 4. PMID: 29660655
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Atherosclerosis
Pharmacological Actions : Hypolipidemic
[+]

Urolithin A significantly attenuated the histopathological hallmarks of cisplatin-induced acute kidney injury and reduced mortality by 63%.Sep 17, 2019

Pubmed Data : Am J Physiol Renal Physiol. 2019 Sep 18. Epub 2019 Sep 18. PMID: 31532243
Article Published Date : Sep 17, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Chemotherapeutic, Renoprotective
[+]

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration.Feb 23, 2020

Pubmed Data : Free Radic Biol Med. 2020 Feb 24 ;150:109-119. Epub 2020 Feb 24. PMID: 32105828
Article Published Date : Feb 23, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic
[+]

Urolithin A attenuated ox-LDL-induced cholesterol accumulation in macrophages partly through regulating miR-33a and ERK/AMPK/SREBP1 signaling pathways.Mar 31, 2020

Pubmed Data : Food Funct. 2020 Apr 1 ;11(4):3432-3440. Epub 2020 Apr 1. PMID: 32236173
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Atherosclerosis, Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents, MicroRNA modulator
[+]

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm (Lond). 2020 ;17:13. Epub 2020 Mar 24. PMID: 32210738
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
[+]

An overview of natural plant products in the treatment of hepatocellular carcinoma.Jun 02, 2018

Pubmed Data : Anticancer Agents Med Chem. 2018 Jun 3. Epub 2018 Jun 3. PMID: 29866017
Article Published Date : Jun 02, 2018
Study Type : Review
Additional Links
Substances : Caffeine, Curcumin, Emodin, Lycopene, Phloretin, Quercetin, Resveratrol, Silibinin, Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

Ellagic acid and urolithin A modulate the immune response in LPS-stimulated U937 monocytic cells and THP-1 differentiated macrophages.Aug 23, 2020

Pubmed Data : Food Funct. 2020 Aug 24. Epub 2020 Aug 24. PMID: 32832941
Article Published Date : Aug 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ellagic acid and urolithins A and B differentially regulate fat accumulation and inflammation in 3T3-L1 adipocytes.Mar 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Mar 18 ;21(6). Epub 2020 Mar 18. PMID: 32197417
Article Published Date : Mar 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effects of urolithin A on H2O2-induced oxidative stress-mediated apoptosis in SK-N-MC cells.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2020 Feb ;14(1):3-11. Epub 2019 Oct 18. PMID: 32042368
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Potential of the ellagic acid-derived gut microbiota metabolite - urolithin A in gastrointestinal protection.Jun 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2020 Jun 21 ;26(23):3170-3181. PMID: 32684733
Article Published Date : Jun 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colorectal Cancer, Inflammatory Bowel Diseases, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Gastroprotective
[+]

The gut microbiota metabolite urolithin A induces p53-dependent cellular senescence in human colon cancer cells.Apr 30, 2020

Pubmed Data : Food Chem Toxicol. 2020 May ;139:111260. Epub 2020 Mar 13. PMID: 32179165
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Tumor Suppressor Protein p53 Upregulation
[+]

The metabolite urolithin-A ameliorates oxidative stress in neuro-2a cells.Feb 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Feb 21 ;9(2). Epub 2020 Feb 21. PMID: 32098107
Article Published Date : Feb 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

The use of dietary urolithin A in cancer prevention or as adjuvant therapy is promising.Jan 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2020 Jan 24:e1900390. Epub 2020 Jan 24. PMID: 31976617
Article Published Date : Jan 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic
[+]

These findings indicated that urolithin A exerted a antiproliferative effect in liver cancer cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2018 ;51(7):e7220. Epub 2018 May 7. PMID: 29742265
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
[+]

These results indicate a potential role of urolithin A as a chemopreventive agent for prostate cancer.May 11, 2015

Pubmed Data : Eur J Nutr. 2015 May 12. Epub 2015 May 12. PMID: 25962506
Article Published Date : May 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A , Walnut
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, P21 Activation
[+]

These results suggest that dietary consumption of urolithin A could induce autophagy and inhibit human colorectal cancer cell metastasis.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Carcinog. 2018 Feb ;57(2):193-200. Epub 2017 Nov 26. PMID: 28976622
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Autophagy Up-regulation
[+]

This explains from a molecular perspective the beneficial effects and traditional use of pomegranate in the prevention of metabolic-associated disorders.Mar 27, 2018

Pubmed Data : J Ethnopharmacol. 2018 Mar 28 ;220:67-74. Epub 2018 Mar 28. PMID: 29604377
Article Published Date : Mar 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Diabetic Complications
Pharmacological Actions : Alpha-glucosidase inhibitor
[+]

Urolithin A could inhibit cell proliferation and reduce oxidative stress status in liver cancer. Jul 31, 2015

Pubmed Data : Toxicol In Vitro. 2015 Aug ;29(5):1107-15. Epub 2015 Apr 21. PMID: 25910917
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells.Mar 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2019 Mar 12 ;40(1):93-101. PMID: 30418550
Article Published Date : Mar 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner.Jun 07, 2019

Pubmed Data : Eur J Nutr. 2019 Jun 8. Epub 2019 Jun 8. PMID: 31177307
Article Published Date : Jun 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Urolithin A may exert neuroprotective effects and may aid in preventing D-gal-induced brain aging.Sep 30, 2019

Pubmed Data : Neurotherapeutics. 2019 Oct ;16(4):1269-1282. PMID: 31420820
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Urolithin A modulates ERα-dependent gene expression and thereby inhibiting endometrial cancer proliferation.Jun 24, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27342949
Article Published Date : Jun 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Endometrial Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Gene Expression Regulation
[+]

Urolithin A showed a strong potential of anti-aging.Sep 13, 2018

Pubmed Data : Rejuvenation Res. 2018 Sep 14. Epub 2018 Sep 14. PMID: 30215291
Article Published Date : Sep 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Aging Skin
Pharmacological Actions : Anti-Apoptotic, Matrix metalloproteinase-1 (MMP-1) inhibitor, Nrf2 activation
[+]

Urolithins A and B attenuated LPS-induced inflammation in BV2 microglia.Jan 23, 2018

Pubmed Data : J Agric Food Chem. 2018 Jan 24 ;66(3):571-580. Epub 2018 Jan 16. PMID: 29336147
Article Published Date : Jan 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Copyright: barmaleeva / 123RF Stock Photo

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

Connect with GreenMedInfo

MeWe

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.