Urolithin A

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36 Diseases Researched for Urolithin A
NameACCKFocus
Dysbiosis110Locked
Mitochondrial Dysfunction 110Locked
Chemotherapy-Induced Toxicity: Cisplatin36Locked
Insulin Resistance36Locked
Inflammation35Locked
Brain Inflammation 24Locked
Colon Cancer34Locked
Degenerative Disk Disease24Locked
High Fat Diet24Locked
Hyperglycemia24Locked
Liver Cancer44Locked
Prostate Cancer34Locked
Alzheimer's Disease23Locked
Atherosclerosis23Locked
Diabetic Complications23Locked
Osteoarthritis23Locked
Brain: Oxidative Stress22Locked
Cachexia12Locked
Cerebral Ischemia12Locked
Colorectal Cancer22Locked
Diabetes Mellitus: Type 212Locked
Fatty Liver12Locked
Gout12Locked
Hyperuricemia12Locked
Kidney Damage: Drug-Induced12Locked
Lipopolysaccharide-Induced Toxicity22Locked
Obesity12Locked
Parkinson's Disease12Locked
Stroke: Ischemic12Locked
Aging Skin11Locked
Cancers: All11Locked
Endometrial Cancer11Locked
Hydrogen Peroxide Induced Toxicity11Locked
Hypercholesterolemia11Locked
Inflammatory Bowel Diseases11Locked
Neurodegenerative Diseases11Locked
39 Pharmacological Actions Researched for Urolithin A
NameACCKFocus
Anti-Inflammatory Agents1321Locked
Neuroprotective Agents914Locked
Cytoprotective212Locked
Gastrointestinal Agents212Locked
Anti-Apoptotic69Locked
Antioxidants69Locked
Antiproliferative 78Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor57Locked
Interleukin-1 beta downregulation35Locked
Autophagy Up-regulation34Locked
Chemopreventive44Locked
Chemoprotective Agents24Locked
Renoprotective24Locked
Apoptotic33Locked
Cell cycle arrest23Locked
Chemotherapeutic23Locked
Interleukin-6 Downregulation23Locked
Pancreato Protective Agents23Locked
Tumor Suppressor Protein p53 Upregulation33Locked
Anti-metastatic22Locked
Chemosensitizer12Locked
Cyclooxygenase 2 Inhibitors12Locked
Hypoglycemic Agents12Locked
Hypolipidemic12Locked
Insulin Sensitizers12Locked
Matrix Metalloproteinase-13 (MMP-13) Inhibitor12Locked
Nitric Oxide Inhibitor12Locked
P21 Activation22Locked
Postaglandin PGE2 downregulation 12Locked
Uricosuric Agents12Locked
Alpha-glucosidase inhibitor 11Locked
Anticholesteremic Agents11Locked
Chondroprotective11Locked
Gastroprotective11Locked
Matrix metalloproteinase-1 (MMP-1) inhibitor11Locked
MicroRNA modulator11Locked
Nrf2 activation11Locked
Superoxide Dismutase Up-regulation11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
57 Abstracts with Urolithin A Research

[+]

Direct supplementation with urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults.Jun 10, 2021

Pubmed Data : Eur J Clin Nutr. 2021 Jun 11. Epub 2021 Jun 11. PMID: 34117375
Article Published Date : Jun 10, 2021
Study Type : Human Study
Additional Links
Substances : Urolithin A
Pharmacological Actions : Gastrointestinal Agents
[+]

In UA producers, the genera Butyrivibrio, Enterobacter, Escherichia, Lactobacillus, Prevotella, Serratia and Veillonella were increased and Collinsella decreased significantly at week 4 compared to baseline.Jul 19, 2015

Pubmed Data : Food Funct. 2015 Jul 20. Epub 2015 Jul 20. PMID: 26189645
Article Published Date : Jul 19, 2015
Study Type : Human Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Dysbiosis
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Metabolites, Microbiota
[+]

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.May 31, 2019

Pubmed Data : Nat Metab. 2019 Jun ;1(6):595-603. Epub 2019 Jun 14. PMID: 32694802
Article Published Date : May 31, 2019
Study Type : Human Study
Additional Links
Substances : Urolithin A
Diseases : Mitochondrial Dysfunction
Pharmacological Actions : Cytoprotective
[+]

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Biol. 2020 03 ;18(3):e3000688. Epub 2020 Mar 27. PMID: 32218572
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Fatty Liver, Insulin Resistance, Obesity
Additional Keywords : Anti-Obesity Agents
[+]

Antihyperuricemic effect of urolithin A in cultured hepatocytes and model mice.Nov 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Nov 4 ;25(21). Epub 2020 Nov 4. PMID: 33158257
Article Published Date : Nov 03, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Gout, Hyperuricemia
Pharmacological Actions : Uricosuric Agents
[+]

Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.Apr 30, 2015

Pubmed Data : Food Funct. 2015 May ;6(5):1460-9. PMID: 25857357
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Cell cycle arrest, Chemosensitizer
Additional Keywords : Drug: 5-flourouracil, Metabolites, Microbiota
[+]

Ellagic acid and its microbial metabolite urolithin A alleviate diet-induced insulin resistance in mice.Aug 10, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Aug 11:e2000091. Epub 2020 Aug 11. PMID: 32783299
Article Published Date : Aug 10, 2020
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Insulin Resistance
Pharmacological Actions : Hypoglycemic Agents
[+]

Emblic leafflower (Phyllanthus emblica L.) fruits ameliorate vascular smooth muscle cell dysfunction in hyperglycemia.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:8478943. Epub 2018 Mar 6. PMID: 29692859
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Amla Fruit, Urolithin A
Diseases : Diabetic Complications, Hyperglycemia
Pharmacological Actions : Cytoprotective
[+]

Neuroprotective effects of pomegranate juice against Parkinson's disease.Dec 26, 2019

Pubmed Data : Int J Mol Sci. 2019 Dec 27 ;21(1). Epub 2019 Dec 27. PMID: 31892167
Article Published Date : Dec 26, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin.Mar 24, 2020

Pubmed Data : J Ethnopharmacol. 2020 Mar 25 ;250:112479. Epub 2019 Dec 14. PMID: 31846746
Article Published Date : Mar 24, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Diabetes Mellitus: Type 2, High Fat Diet
Pharmacological Actions : Pancreato Protective Agents
[+]

Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2020 Dec ;24:100825. Epub 2020 Oct 13. PMID: 33088927
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A , Vitamin D
Additional Keywords : Gene Expression Regulation, Natural Substance Synergy
[+]

Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses in rats fed a high-fat diet.Nov 12, 2019

Pubmed Data : Food Funct. 2019 Nov 13. Epub 2019 Nov 13. PMID: 31720661
Article Published Date : Nov 12, 2019
Study Type : Animal Study
Additional Links
Substances : Pomegranate Peel, Pomegranate Polyphenols, Punicalagin, Urolithin A
Diseases : High Fat Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents
[+]

Supplementation with a punicalagin-rich pomegranate extract may protect skeletal muscle against an acute inflammation.Nov 01, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Nov 2. Epub 2016 Aug 2. PMID: 27804206
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Punicalagin, Urolithin A
Diseases : Cachexia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The protective effect of urolithin a on cisplatin-induced nephrotoxicity.Jun 30, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jul ;129:108-114. Epub 2019 Apr 20. PMID: 31014901
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Renoprotective
[+]

Urolithin A attenuates memory impairment and neuroinflammation.Mar 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2019 Mar 14 ;16(1):62. Epub 2019 Mar 14. PMID: 30871577
Article Published Date : Mar 13, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Brain Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Urolithin A downregulates androgen receptor activation and suppresses growth of prostate cancer.Sep 30, 2018

Pubmed Data : Mol Carcinog. 2018 Oct ;57(10):1332-1341. Epub 2018 Aug 1. PMID: 30069922
Article Published Date : Sep 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative
[+]

Urolithin A improves insulin sensitivity through augmentation of mitochondrial function and biogenesis.Mar 31, 2019

Pubmed Data : Obesity (Silver Spring). 2019 Apr ;27(4):612-620. Epub 2019 Feb 15. PMID: 30768775
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Insulin Resistance
Pharmacological Actions : Insulin Sensitizers
[+]

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy.Apr 06, 2021

Pubmed Data : Sci Transl Med. 2021 Apr 7 ;13(588). PMID: 33827972
Article Published Date : Apr 06, 2021
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Muscular Dystrophy
[+]

Urolithin A is a promising candidate for the development of therapies to prevent diabetes mellitus-associated Alzheimer's disease pathogenesis.Jul 22, 2020

Pubmed Data : Cell Death Differ. 2020 Jul 23. Epub 2020 Jul 23. PMID: 32704090
Article Published Date : Jul 22, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Alzheimer's Disease, Hyperglycemia
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Urolithin A may be a useful therapeutic agent for the treatment of Intervertebral disc degeneration.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1043. Epub 2018 Sep 18. PMID: 30283339
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A may be adopted as a new therapeutic agent for the treatment of osteoarthritis.Sep 08, 2019

Pubmed Data : Food Funct. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31497826
Article Published Date : Sep 08, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Urolithin A mitigates cisplatin-induced nephrotoxicity in rats.Aug 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2017 Aug 7. Epub 2017 Aug 7. PMID: 28784820
Article Published Date : Aug 06, 2017
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents
[+]

Urolithin A prevents focal cerebral ischemic injury.Nov 09, 2020

Pubmed Data : Neuroscience. 2020 Nov 10 ;448:94-106. Epub 2020 Sep 15. PMID: 32946950
Article Published Date : Nov 09, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Brain Inflammation , Stroke: Ischemic
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Neuroprotective Agents
[+]

Urolithin A protected against ischemic neuronal injury by reinforcing autophagy rather than mitophagy.Apr 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : CNS Neurosci Ther. 2019 Apr 11. Epub 2019 Apr 11. PMID: 30972969
Article Published Date : Apr 10, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Cerebral Ischemia
Pharmacological Actions : Autophagy Up-regulation, Neuroprotective Agents
[+]

Urolithin A shows anti-atherosclerotic activity.May 31, 2018

Pubmed Data : Pharmacol Rep. 2018 Jun ;70(3):519-524. Epub 2017 May 4. PMID: 29660655
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Atherosclerosis
Pharmacological Actions : Hypolipidemic
[+]

Urolithin A significantly attenuated the histopathological hallmarks of cisplatin-induced acute kidney injury and reduced mortality by 63%.Sep 17, 2019

Pubmed Data : Am J Physiol Renal Physiol. 2019 Sep 18. Epub 2019 Sep 18. PMID: 31532243
Article Published Date : Sep 17, 2019
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Chemotherapeutic, Renoprotective
[+]

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration.Feb 23, 2020

Pubmed Data : Free Radic Biol Med. 2020 Feb 24 ;150:109-119. Epub 2020 Feb 24. PMID: 32105828
Article Published Date : Feb 23, 2020
Study Type : Animal Study
Additional Links
Substances : Urolithin A
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic
[+]

Urolithin A attenuated ox-LDL-induced cholesterol accumulation in macrophages partly through regulating miR-33a and ERK/AMPK/SREBP1 signaling pathways.Mar 31, 2020

Pubmed Data : Food Funct. 2020 Apr 1 ;11(4):3432-3440. Epub 2020 Apr 1. PMID: 32236173
Article Published Date : Mar 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Atherosclerosis, Hypercholesterolemia
Pharmacological Actions : Anticholesteremic Agents, MicroRNA modulator
[+]

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm (Lond). 2020 ;17:13. Epub 2020 Mar 24. PMID: 32210738
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation
[+]

An overview of natural plant products in the treatment of hepatocellular carcinoma.Jun 02, 2018

Pubmed Data : Anticancer Agents Med Chem. 2018 Jun 3. Epub 2018 Jun 3. PMID: 29866017
Article Published Date : Jun 02, 2018
Study Type : Review
Additional Links
Substances : Caffeine, Curcumin, Emodin, Lycopene, Phloretin, Quercetin, Resveratrol, Silibinin, Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive
[+]

Ellagic acid and urolithin A modulate the immune response in LPS-stimulated U937 monocytic cells and THP-1 differentiated macrophages.Aug 23, 2020

Pubmed Data : Food Funct. 2020 Aug 24. Epub 2020 Aug 24. PMID: 32832941
Article Published Date : Aug 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ellagic acid and urolithins A and B differentially regulate fat accumulation and inflammation in 3T3-L1 adipocytes.Mar 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Mar 18 ;21(6). Epub 2020 Mar 18. PMID: 32197417
Article Published Date : Mar 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid, Urolithin A
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gut metabolite Urolithin A mitigates ionizing radiation-induced intestinal damage.Sep 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2021 Oct 1. Epub 2021 Oct 1. PMID: 34595829
Article Published Date : Sep 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Radiation
Pharmacological Actions : Radioprotective
[+]

Immunomodulatory role of urolithin A on metabolic diseases. Feb 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2021 Feb 15 ;9(2). Epub 2021 Feb 15. PMID: 33671880
Article Published Date : Feb 14, 2021
Study Type : Review
Additional Links
Substances : Urolithin A
Diseases : Metabolic Diseases
Pharmacological Actions : Immunomodulatory
[+]

Impact of the natural compound urolithin A on health, disease, and aging.May 20, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Trends Mol Med. 2021 May 21. Epub 2021 May 21. PMID: 34030963
Article Published Date : May 20, 2021
Study Type : Review
Additional Links
Substances : Urolithin A
Diseases : Aging, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Neuroprotective effects of urolithin A on H2O2-induced oxidative stress-mediated apoptosis in SK-N-MC cells.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2020 Feb ;14(1):3-11. Epub 2019 Oct 18. PMID: 32042368
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Brain: Oxidative Stress, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

Potential of the ellagic acid-derived gut microbiota metabolite - urolithin A in gastrointestinal protection.Jun 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2020 Jun 21 ;26(23):3170-3181. PMID: 32684733
Article Published Date : Jun 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colorectal Cancer, Inflammatory Bowel Diseases, Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Gastroprotective
[+]

Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease.Sep 08, 2021

Pubmed Data : Hum Mol Genet. 2021 Sep 9. Epub 2021 Sep 9. PMID: 34505123
Article Published Date : Sep 08, 2021
Study Type : In Vitro Study
Additional Links
Substances : Nicotinamide, Tomatidine , Urolithin A
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

The gut microbiota metabolite urolithin A induces p53-dependent cellular senescence in human colon cancer cells.Apr 30, 2020

Pubmed Data : Food Chem Toxicol. 2020 May ;139:111260. Epub 2020 Mar 13. PMID: 32179165
Article Published Date : Apr 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive, Tumor Suppressor Protein p53 Upregulation
[+]

The metabolite urolithin-A ameliorates oxidative stress in neuro-2a cells.Feb 20, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Feb 21 ;9(2). Epub 2020 Feb 21. PMID: 32098107
Article Published Date : Feb 20, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
[+]

The use of dietary urolithin A in cancer prevention or as adjuvant therapy is promising.Jan 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Nutr Food Res. 2020 Jan 24:e1900390. Epub 2020 Jan 24. PMID: 31976617
Article Published Date : Jan 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Cancers: All
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic
[+]

These findings indicated that urolithin A exerted a antiproliferative effect in liver cancer cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Braz J Med Biol Res. 2018 ;51(7):e7220. Epub 2018 May 7. PMID: 29742265
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative
[+]

These results highlighted the role of pomegranate in regulation of EMT program in lung cancer.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2021 ;14:3199-3208. Epub 2021 May 17. PMID: 34040386
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic
[+]

These results indicate a potential role of urolithin A as a chemopreventive agent for prostate cancer.May 11, 2015

Pubmed Data : Eur J Nutr. 2015 May 12. Epub 2015 May 12. PMID: 25962506
Article Published Date : May 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A , Walnut
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, P21 Activation
[+]

These results suggest that dietary consumption of urolithin A could induce autophagy and inhibit human colorectal cancer cell metastasis.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Carcinog. 2018 Feb ;57(2):193-200. Epub 2017 Nov 26. PMID: 28976622
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Autophagy Up-regulation
[+]

This explains from a molecular perspective the beneficial effects and traditional use of pomegranate in the prevention of metabolic-associated disorders.Mar 27, 2018

Pubmed Data : J Ethnopharmacol. 2018 Mar 28 ;220:67-74. Epub 2018 Mar 28. PMID: 29604377
Article Published Date : Mar 27, 2018
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate, Urolithin A
Diseases : Diabetic Complications
Pharmacological Actions : Alpha-glucosidase inhibitor
[+]

Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EBioMedicine. 2021 Feb ;64:103227. Epub 2021 Jan 30. PMID: 33530002
Article Published Date : Jan 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Encephalomyelitis
Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation
[+]

Urolithin A and B alter cellular metabolism and induce metabolites associated with apoptosis in leukemic cells.May 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 May 22 ;22(11). Epub 2021 May 22. PMID: 34067305
Article Published Date : May 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Urolithin A could inhibit cell proliferation and reduce oxidative stress status in liver cancer. Jul 31, 2015

Pubmed Data : Toxicol In Vitro. 2015 Aug ;29(5):1107-15. Epub 2015 Apr 21. PMID: 25910917
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative , Chemopreventive, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation, Wnt/β-catenin signaling pathway modulation
[+]

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells.Mar 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2019 Mar 12 ;40(1):93-101. PMID: 30418550
Article Published Date : Mar 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative
[+]

Urolithin A induces cell cycle arrest and apoptosis in colorectal cancer cells.Apr 30, 2021

Pubmed Data : Cell Stress Chaperones. 2021 May ;26(3):473-493. Epub 2021 Mar 5. PMID: 33666815
Article Published Date : Apr 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner.Jun 07, 2019

Pubmed Data : Eur J Nutr. 2019 Jun 8. Epub 2019 Jun 8. PMID: 31177307
Article Published Date : Jun 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Urolithin A may exert neuroprotective effects and may aid in preventing D-gal-induced brain aging.Sep 30, 2019

Pubmed Data : Neurotherapeutics. 2019 Oct ;16(4):1269-1282. PMID: 31420820
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Alzheimer's Disease, Neurodegenerative Diseases
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
[+]

Urolithin A modulates ERα-dependent gene expression and thereby inhibiting endometrial cancer proliferation.Jun 24, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Jun 25. Epub 2016 Jun 25. PMID: 27342949
Article Published Date : Jun 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Endometrial Cancer
Pharmacological Actions : Antiproliferative
Additional Keywords : Gene Expression Regulation
[+]

Urolithin A protects pancreatic β Cells from apoptosis by activating autophagy.Nov 23, 2020

Pubmed Data : J Ethnopharmacol. 2020 Nov 24:113628. Epub 2020 Nov 24. PMID: 33246115
Article Published Date : Nov 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Pharmacological Actions : Anti-Apoptotic, Autophagy Up-regulation, Pancreato Protective Agents
[+]

Urolithin A showed a strong potential of anti-aging.Sep 13, 2018

Pubmed Data : Rejuvenation Res. 2018 Sep 14. Epub 2018 Sep 14. PMID: 30215291
Article Published Date : Sep 13, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Aging Skin
Pharmacological Actions : Anti-Apoptotic, Matrix metalloproteinase-1 (MMP-1) inhibitor, Nrf2 activation
[+]

Urolithins A and B attenuated LPS-induced inflammation in BV2 microglia.Jan 23, 2018

Pubmed Data : J Agric Food Chem. 2018 Jan 24 ;66(3):571-580. Epub 2018 Jan 16. PMID: 29336147
Article Published Date : Jan 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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