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40 Diseases Researched for Wogonin
NameACCKFocus
Cancers: Drug Resistant511Locked
Breast Cancer49Locked
Cancers: Multi-Drug Resistant15Locked
Colon Cancer15Locked
Leukemia45Locked
Asthma24Locked
Liver Cancer34Locked
Osteoarthritis34Locked
Cancers: All33Locked
Gastric Cancer23Locked
Lung Cancer23Locked
Ovarian Cancer33Locked
Alcohol Toxicity 12Locked
Alzheimer's Disease12Locked
Chronic Lymphocytic Leukemia12Locked
Colorectal Cancer12Locked
Colorectal Cancer: Prevention 12Locked
Corticosteroid-Induced Toxicity12Locked
DNA damage12Locked
Head and Neck Cancer12Locked
Leukemia: Chronic myelogenous leukemia (CML) 12Locked
Lung Cancer: Metastatic12Locked
Lymphoma12Locked
Multiple Myeloma12Locked
Nonalcoholic fatty liver disease (NAFLD) 12Locked
Osteosarcoma22Locked
Oxidative Stress12Locked
Acute Myeloid Leukemia11Locked
Acute lymphoblastic leukemia (ALL)11Locked
Alcoholic Liver Disease11Locked
Breast Cancer: Triple Negative 11Locked
Cancer Stem Cells11Locked
Cervical Cancer11Locked
Chemotherapy-Induced Toxicity: Cisplatin11Locked
Macular Degeneration11Locked
Myelodysplastic Syndrome11Locked
Non-Small-Cell Lung Carcinoma11Locked
Pancreatic Cancer11Locked
Promyelocytic leukemia 11Locked
Steroid-Induced Toxicity11Locked
51 Pharmacological Actions Researched for Wogonin
NameACCKFocus
Apoptotic1928Locked
Antiproliferative 1323Locked
Chemosensitizer613Locked
Anti-Inflammatory Agents712Locked
Interleukin-6 Downregulation68Locked
Cyclooxygenase 2 Inhibitors57Locked
Interleukin-1 beta downregulation57Locked
NF-kappaB Inhibitor57Locked
Anti-metastatic56Locked
Hypoxia-inducible factor-1 (HIF-1) inhibitor15Locked
PI3K/Akt/signaling suppression15Locked
Antioxidants24Locked
Cell cycle arrest44Locked
Chemotherapeutic34Locked
Chondroprotective34Locked
Interleukin-4 downregulation24Locked
Matrix metalloproteinase-9 (MMP-9) inhibitor44Locked
Tumor Necrosis Factor (TNF) Alpha Inhibitor34Locked
Tumor Suppressor Protein p53 Upregulation44Locked
Angiogenesis Inhibitors23Locked
Antineoplastic Agents23Locked
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor23Locked
Matrix metalloproteinase-3 (MMP-3) inhibitor23Locked
Anti Inflammatory12Locked
Anti-Asthmatic Agents12Locked
Anticarcinogenic Agents12Locked
Autophagy Up-regulation22Locked
Bcl-2 protein down-regulation22Locked
Cyclooxygenase Inhibitors12Locked
DNA Repair Up-regulation12Locked
Estrogen Receptor Modulators12Locked
Immunomodulatory12Locked
Interleukin-5 downregulation12Locked
Neuroprotective Agents12Locked
Nrf2 activation12Locked
Autophagy Inhibitors11Locked
Chemopreventive11Locked
Chemoprotective Agents11Locked
Cyclin D1 Down-Regulation11Locked
Cytotoxic11Locked
EpCAM surface marker down-regulation11Locked
Interleukin-8 downregulation11Locked
Matrix Metalloproteinase-13 (MMP-13) Inhibitor11Locked
Matrix metalloproteinase-2 (MMP-2) inhibitor11Locked
P21 Activation11Locked
Renoprotective11Locked
STAT3 Inhibitor11Locked
Telomerase Inhibitor11Locked
VEGFR3 inhibition 11Locked
Vascular Endothelial Growth Factor Inhibitors11Locked
Wnt/β-catenin signaling pathway modulation11Locked

View the Evidence:
65 Abstracts with Wogonin Research

[+]

Wogonin could increase doxorubicin sensitivity in human breast cancer cells.Dec 31, 2014

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2015 ;61(7):123-7. Epub 2015 Nov 30. PMID: 26638893
Article Published Date : Dec 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Wogonin
Diseases : Breast Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Dose Response
[+]

Wogonin decreased the expression of glycolysis-related proteins, glucose uptake and lactate generation in a dose-dependent manner.Jan 31, 2014

Pubmed Data : Mol Carcinog. 2014 Feb ;53 Suppl 1:E107-18. Epub 2013 Jun 13. PMID: 23761018
Article Published Date : Jan 31, 2014
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Wogonin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Hypoxia-inducible factor-1 (HIF-1) inhibitor, PI3K/Akt/signaling suppression
Additional Keywords : Cancer Glycolysis, Resistance Reversal
[+]

Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anat Cell Biol. 2017 Jun ;50(2):124-134. Epub 2017 Jun 27. PMID: 28713616
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Baicalein, Chinese Skullcap , Wogonin
Diseases : Asthma
Pharmacological Actions : Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-4 downregulation, Interleukin-5 downregulation
[+]

Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity.May 27, 2019

Pubmed Data : Hum Exp Toxicol. 2019 May 28:960327119842635. Epub 2019 May 28. PMID: 31132876
Article Published Date : May 27, 2019
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Cadmium Poisoning , Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Cadmium
[+]

Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53.Jul 17, 2018

Pubmed Data : Pharmacol Res. 2018 Jul 18 ;135:49-59. Epub 2018 Jul 18. PMID: 30031170
Article Published Date : Jul 17, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Colon Cancer, Liver Cancer, Ovarian Cancer
Pharmacological Actions : Antiproliferative , Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Warburg Effect
[+]

There is potential therapeutic value of wogonin in the treatment of asthma.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Biochem Nutr. 2015 Sep ;57(2):105-12. Epub 2015 Jul 30. PMID: 26388667
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Asthma
Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents, Interleukin-4 downregulation
[+]

These results show that the chondroprotective effects of wogonin are produced by its regulation of the gene expression.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Sep ;23(5):442-8. Epub 2015 Sep 1. PMID: 26336584
Article Published Date : Aug 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Matrix metalloproteinase-3 (MMP-3) inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Wogonin and 5-fluorouracil combination treatment caused a significant growth inhibition of human tumor xenografts in vivo.Jul 31, 2013

Pubmed Data : Biochem Cell Biol. 2013 Aug ;91(4):221-9. Epub 2013 Feb 14. PMID: 23859016
Article Published Date : Jul 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Chemosensitizer, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: 5-flourouracil, Natural Substance/Drug Synergy, Plant Extracts
[+]

Wogonin as a potential therapeutic candidate for the therapeutic strategy in colorectal cancer treatment.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1356. Epub 2018 Nov 23. PMID: 30532707
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive
[+]

Wogonin attenuates the deleterious effects of traumatic brain injury.Apr 04, 2019

Pubmed Data : Eur J Pharmacol. 2019 Apr 5 ;848:121-130. Epub 2019 Jan 25. PMID: 30689996
Article Published Date : Apr 04, 2019
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Neuroprotective Agents
[+]

Wogonin can attenuate liver fibrosis via regulating the activation and apoptosis of hepatic stellate cells.Jul 31, 2019

Pubmed Data : Int Immunopharmacol. 2019 Aug 1 ;75:105671. Epub 2019 Aug 1. PMID: 31377590
Article Published Date : Jul 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Apoptotic, Hepatoprotective
[+]

Wogonin can be a promising chemoprotective agent and might be useful to avert secondary leukemia and other drug related cancers.Aug 31, 2013

Pubmed Data : Food Chem Toxicol. 2013 Sep ;59:724-30. Epub 2013 Jul 17. PMID: 23872129
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : DNA damage, Leukemia, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, DNA Repair Up-regulation
Additional Keywords : Epigenetic Modification
Problem Substances : Etoposide
[+]

Wogonin can be developed into an efficient natural sensitizer for resistant human myelogenous leukemiaFeb 01, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Feb 2 ;7:39950. Epub 2017 Feb 2. PMID: 28150717
Article Published Date : Feb 01, 2017
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Cancers: Drug Resistant, Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Chemosensitizer
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Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin J Cancer Res. 2013 Oct ;25(5):505-13. PMID: 24255573
Article Published Date : Sep 30, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Natural Substance/Drug Synergy
[+]

Wogonin could suppress tumor growth and induce cell apoptosis by inhibiting the expression of NF-κB.Feb 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2017 Feb 21 ;17(1):147. Epub 2017 Feb 21. PMID: 28222771
Article Published Date : Feb 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Lymphoma
Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor
[+]

Wogonin effectively suppressed inflammation associated colon carcinogenesis and cancer development in mice.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2014 ;5:e1283. Epub 2014 Jun 5. PMID: 24901054
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Colorectal Cancer, Colorectal Cancer: Prevention
Pharmacological Actions : Anti Inflammatory, Antineoplastic Agents, Antiproliferative , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Wogonin has anticancer activity in both ER-positive and -negative breast cancer cells. Feb 15, 2008

Pubmed Data : Int J Cancer. 2008 Feb 15;122(4):816-22. PMID: 17957784
Article Published Date : Feb 15, 2008
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Estrogen Receptor Modulators
[+]

Wogonin induced antiallergic effects in a murine model of allergic rhinitis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Allergy Rhinol (Providence). 2018 Jan-Dec;9:2152656718764145. Epub 2018 Apr 9. PMID: 29977652
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

wogonin may be a promising multifunctional drug candidate for Alzheimer's disease.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:3545169. Epub 2017 Jun 7. PMID: 28680449
Article Published Date : Dec 31, 2016
Study Type : Transgenic Animal Study
Additional Links
Substances : Wogonin
Diseases : Alzheimer's Disease
Pharmacological Actions : Neuroprotective Agents
[+]

Wogonin might be a potential therapeutic agent for NAFLD.May 05, 2017

Pubmed Data : Biomed Pharmacother. 2017 May 6 ;91:621-631. Epub 2017 May 6. PMID: 28486193
Article Published Date : May 05, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Wogonin mitigates intervertebral disc degeneration.Nov 30, 2018

Pubmed Data : Int Immunopharmacol. 2018 Dec ;65:539-549. Epub 2018 Nov 6. PMID: 30412851
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation
[+]

Wogonin pre-treatment attenuates cisplatin-induced nephrotoxicity.May 15, 2019

Pubmed Data : Chem Biol Interact. 2019 May 16. Epub 2019 May 16. PMID: 31103702
Article Published Date : May 15, 2019
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Wogonin prevents alcohol-induced gastric mucosal damage in rats. Aug 01, 2008

Pubmed Data : Appl Environ Microbiol. 2008 Aug;74(15):4650-5. Epub 2008 Jun 6. PMID: 15139485
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Alcohol Toxicity
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors
[+]

Wogonin represses multiple myeloma stimulated angiogenesis and tumor progression.Dec 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Dec 30. Epub 2015 Dec 30. PMID: 26735336
Article Published Date : Dec 29, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Multiple Myeloma
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Aug 19, 2016

Pubmed Data : Apoptosis. 2016 Aug 20. Epub 2016 Aug 20. PMID: 27544755
Article Published Date : Aug 19, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Cancers: Drug Resistant, Head and Neck Cancer
Pharmacological Actions : Chemosensitizer
Additional Keywords : Selective Cytotoxicity
[+]

Wogonin suppresses tumor cells migration in inflammatory microenvironment by inactivating STAT3 signaling.Jun 28, 2014

Pubmed Data : Mol Carcinog. 2014 Jun 29. Epub 2014 Jun 29. PMID: 24976450
Article Published Date : Jun 28, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic
Additional Keywords : Tumor Microenvironment
[+]

Wogonin treatment prevented leukemia development when given early after transplantation.Jan 10, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Haematologica. 2018 Jan 11. Epub 2018 Jan 11. PMID: 29326123
Article Published Date : Jan 10, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Chronic Lymphocytic Leukemia
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic
[+]

Wogonin, a compound found within Chinese Skullcap, prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid.Jul 01, 2008

Pubmed Data : Dig Dis Sci. 2008 Jul;53(7):1774-84. Epub 2008 Mar 27. PMID: 17404053
Article Published Date : Jul 01, 2008
Study Type : Animal Study
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Corticosteroid-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic
[+]

This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin.Dec 31, 2016

Pubmed Data : Chin J Nat Med. 2017 Jan ;15(1):15-40. PMID: 28259249
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Wogonin
Diseases : Cancers: All, Cancers: Drug Resistant
Pharmacological Actions : Anti-metastatic, Apoptotic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy
[+]

A review of targeting oncogenic transcription factors by polyphenols.Jan 03, 2018

Pubmed Data : Pharmacol Res. 2018 Jan 4. Epub 2018 Jan 4. PMID: 29305909
Article Published Date : Jan 03, 2018
Study Type : Review
Additional Links
Substances : 4-Shogaol, 6-Shogaol, Apigenin, Berberine, Caffeic Acid, Capsaicin, Cardamonin, Chrysin, Curcumin, EGCG (Epigallocatechin gallate), Ellagic Acid, Fisetin, Gingerol , Luteolin, Mangiferin, Piperlongumine , Polyphenols, Pterostilbene, Quercetin, Resveratrol, Rutin, Sesamin, Ursolic Acid, Wogonin, Xanthohumol
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, NF-kappaB Inhibitor, STAT3 Inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

A review of the anti-cancer natural products isolated from Chinese medicinal herbs.Jul 21, 2011

Pubmed Data : Chin Med. 2011 Jul 22 ;6(1):27. Epub 2011 Jul 22. PMID: 21777476
Article Published Date : Jul 21, 2011
Study Type : Review
Additional Links
Substances : Artemisinin, Berberine, Beta-Elemene, Curcumin, Emodin, Flavonoids, Ginsenosides, Shikonin, Silibinin, Ursolic Acid, Wogonin
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Chemotherapeutic
Additional Keywords : Traditional Chinese Medicine
[+]

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects.Mar 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Mar 3 ;7:43789. Epub 2017 Mar 3. PMID: 28256567
Article Published Date : Mar 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.Feb 14, 2013

Pubmed Data : Phytomedicine. 2013 Feb 15 ;20(3-4):328-36. Epub 2012 Dec 6. PMID: 23219337
Article Published Date : Feb 14, 2013
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Osteosarcoma
Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, VEGFR3 inhibition
Additional Keywords : Phytotherapy
[+]

Anticancer effect of nor-wogonin on human triple-negative breast cancer cells via downregulation. Mar 31, 2019

Pubmed Data : Pharmacol Rep. 2019 Apr ;71(2):289-298. Epub 2019 Jan 7. PMID: 30826569
Article Published Date : Mar 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative
[+]

Oridonin and wogonin may suppress ovarian cancer stem cells.Jan 01, 2012

Pubmed Data : Discov Med. 2012 Jan ;13(68):7-17. PMID: 22284780
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Oridonin, Wogonin
Diseases : Cancer Stem Cells, Ovarian Cancer
Pharmacological Actions : Antiproliferative , EpCAM surface marker down-regulation
[+]

Phytochemical modulation of apoptosis and autophagy could be used to overcome chemoresistance in leukemic stem cells.Dec 31, 2016

Pubmed Data : Int Rev Neurobiol. 2017 ;135:249-278. Epub 2017 Apr 12. PMID: 28807161
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Chrysin, Curcumin, Resveratrol, Wogonin
Diseases : Acute lymphoblastic leukemia (ALL), Acute Myeloid Leukemia, Leukemia
Pharmacological Actions : Apoptotic, Autophagy Up-regulation
Additional Keywords : Cancer Stem Cells
[+]

Sustained cytotoxicity of wogonin on breast cancer cells by encapsulation in solid lipid nanoparticles.Mar 12, 2018

Pubmed Data : Nanomaterials (Basel). 2018 Mar 13 ;8(3). Epub 2018 Mar 13. PMID: 29533979
Article Published Date : Mar 12, 2018
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer
Pharmacological Actions : Cytotoxic
[+]

The present data suggests a potential clinical impact of wogonin for ovarian cancer patients.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2017 ;2017:9381513. Epub 2017 Oct 18. PMID: 29181409
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation, Vascular Endothelial Growth Factor Inhibitors
[+]

This review we have discussed recently discovered therapeutic potential of wogonin in the treatment of diabetic cardiomyopathy.Jul 07, 2019

Pubmed Data : Curr Pharm Des. 2019 Jul 8. Epub 2019 Jul 8. PMID: 31298148
Article Published Date : Jul 07, 2019
Study Type : Review
Additional Links
Substances : Wogonin
Diseases : Cardiomyopathy, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Wogonin affects proliferation and the energy metabolism of SGC-7901 and A549 cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jan ;17(1):911-918. Epub 2018 Nov 28. PMID: 30651880
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Gastric Cancer, Lung Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative
[+]

Wogonin alleviates hyperglycemia through increased glucose entry into cells via AKT/GLUT4 pathway.Jul 21, 2019

Pubmed Data : Curr Pharm Des. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31333118
Article Published Date : Jul 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Diabetes Mellitus: Type 2, Hyperglycemia
Pharmacological Actions : Hypoglycemic Agents
[+]

Wogonin and chrysin may contribute to overcoming drug resistance in non-small cell lung cancer cells. May 01, 2007

Pubmed Data : Int J Cancer. 2007 May 1;120(9):2019-27. PMID: 17266043
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Chrysin, Flavonoids, Wogonin
Diseases : Cancers: Drug Resistant, Lung Cancer, Non-Small-Cell Lung Carcinoma
Pharmacological Actions : Apoptotic, Cell cycle arrest, Interleukin-6 Downregulation
Additional Keywords : Drug: Doxorubicin
[+]

Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease.Aug 31, 2017

Pubmed Data : Int Immunopharmacol. 2017 Sep ;50:95-106. Epub 2017 Jun 21. PMID: 28646664
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Wogonin can be a potential therapeutic candidate for enhancing the efficacy of oxaliplatin in gastric cancer treatment.Jan 14, 2018

Pubmed Data : Phytomedicine. 2018 Jan 15 ;39:168-175. Epub 2017 Dec 18. PMID: 29433678
Article Published Date : Jan 14, 2018
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin
[+]

Wogonin could be a potential therapy for the treatment of age-related macular degeneration.Mar 31, 2017

Pubmed Data : Mol Med Rep. 2017 Apr ;15(4):2289-2295. Epub 2017 Feb 28. PMID: 28260013
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Macular Degeneration
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Wogonin could be an ideal candidate for increasing sorafenibs activity in hepatocellular carcinoma therapy.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Jun ;13(6):5028-5034. Epub 2017 Apr 20. PMID: 28599504
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Inhibitors
Additional Keywords : Chemothapeutic Synergy: Sorafenib
[+]

Wogonin has a synergistic effect with 5-fluorouracil, etoposide, and adriamycin to enhance chemotherapy and reverse drug resistance.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2016 ;9:2935-43. Epub 2016 May 17. PMID: 27274287
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Apoptotic, Chemosensitizer
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Natural Substance/Drug Synergy
[+]

Wogonin has anti-hepatitis B virus effects. Nov 30, 2000

Pubmed Data : Planta Med. 2000 Dec ;66(8):694-8. PMID: 11199123
Article Published Date : Nov 30, 2000
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Hepatitis B
Pharmacological Actions : Antiviral Agents
[+]

Wogonin has the ability to inhibit the proliferation of gastric cancer cells.May 31, 2016

Pubmed Data : Zhong Yao Cai. 2016 Jun ;39(6):1372-6. PMID: 30156810
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic
[+]

Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells.Jan 31, 2012

Pubmed Data : Int Immunopharmacol. 2012 Feb ;12(2):334-41. Epub 2011 Dec 17. PMID: 22182776
Article Published Date : Jan 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Wogonin induces apoptosis of human osteosarcoma cancer stem cells.Jun 11, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jun 12 ;17(1):304. Epub 2017 Jun 12. PMID: 28606135
Article Published Date : Jun 11, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Cancer Stem Cells
[+]

Wogonin induces Beclin-1/PI3K and reactive oxygen species-mediated autophagy in human pancreatic cancer cells.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Dec ;12(6):5059-5067. Epub 2016 Nov 8. PMID: 28105213
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Pancreatic Cancer
Pharmacological Actions : Autophagy Up-regulation
[+]

Wogonin induces differentiation and cell cycle arrest in human leukemia cells. Sep 04, 2008

Pubmed Data : Eur J Pharmacol. 2008 Sep 4;591(1-3):7-12. Epub 2008 Jun 12. PMID: 18577379
Article Published Date : Sep 04, 2008
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Leukemia
Pharmacological Actions : Cell cycle arrest
[+]

Wogonin induces programmed cell death in human ovarian cancer cells. Aug 01, 2003

Pubmed Data : Ai Zheng. 2003 Aug;22(8):801-5. PMID: 12917023
Article Published Date : Aug 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic
[+]

Wogonin inhibits the proliferation of myelodysplastic syndrome cells.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7285-92. Epub 2015 Sep 23. PMID: 26398525
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Myelodysplastic Syndrome
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
[+]

Wogonin intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes.Aug 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Aug 25 ;274:13-23. Epub 2017 Jul 5. PMID: 28688942
Article Published Date : Aug 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Osteoarthritis
Pharmacological Actions : Chondroprotective, Interleukin-1 beta downregulation
[+]

Wogonin might be a potent treatment option for disrupting the tumor metastasis that favours liver cancer development.Feb 10, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Feb 11 ;23(2). Epub 2018 Feb 11. PMID: 29439451
Article Published Date : Feb 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Wogonin possesses a potent anti-influenza activity.Dec 31, 2017

Pubmed Data : Acta Virol. 2018 ;62(1):78-85. PMID: 29521106
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Influenza A
Pharmacological Actions : Antiviral Agents
[+]

Wogonin protects against cisplatin-induced acute kidney injury.Dec 31, 2017

Pubmed Data : Lab Invest. 2018 Jan ;98(1):79-94. Epub 2017 Dec 4. PMID: 29200200
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Wogonin sensitizes TNF alpha-resistant leukemia cells to TNF alpha-induced programmed cell death. Dec 01, 2006

Pubmed Data : Blood. 2006 Dec 1;108(12):3700-6. Epub 2006 Aug 24. PMID: 16931628
Article Published Date : Dec 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Leukemia
Pharmacological Actions : Apoptotic, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Wogonin suppresses the LPS‑enhanced invasiveness of MDA‑MB‑231 breast cancer cells.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2018 Oct ;42(4):1899-1908. Epub 2018 Jul 12. PMID: 30015917
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Wogonin was cytotoxic to HPV 16 cervical cancer cells SiHa and CaSki but not to HPV negative cells.Jul 31, 2013

Pubmed Data : Cell Biol Toxicol. 2013 Aug ;29(4):259-72. Epub 2013 Aug 18. PMID: 23955116
Article Published Date : Jul 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Wogonin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Cytotoxic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Oncogene Proteins, Plant Extracts, Selective Cytotoxicity
[+]

Wogonin, a compound within Chinese Skullcap, attenuates the adverse side effects of glucocorticoid-induced changes, without reducing the drug's anti-inflammatory effects.Aug 01, 2007

Pubmed Data : J Pharmacol Sci. 2007 Aug;104(4):355-65. Epub 2007 Aug 10. PMID:17690528
Article Published Date : Aug 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Steroid-Induced Toxicity
Additional Keywords : Drug Side Effect Attenuation
[+]

Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the promyelocytic leukemia cells.Jan 01, 2010

Pubmed Data : Phytomedicine. 2010 Jan;17(1):47-54. Epub 2009 Jul 3. PMID: 19577445
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Chinese Skullcap , Wogonin
Diseases : Promyelocytic leukemia
Pharmacological Actions : Apoptotic, Telomerase Inhibitor
[+]

Wogonoside might be a potential therapeutic agent for the treatment of tumor metastasis in breast cancer.Aug 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2017 Aug 3 ;36(1):103. Epub 2017 Aug 3. PMID: 28774312
Article Published Date : Aug 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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