Retinoic Acid https://greenmedinfo.com/category/toxic-ingredients/retinoic-acid en Ursolic acid might be a potential therapeutic of retinoic acid-induced acute osteoporosis. https://greenmedinfo.com/article/ursolic-acid-might-be-potential-therapeutic-retinoic-acid-induced-acute-osteop PMID:  Chin J Integr Med. 2019 Mar ;25(3):210-215. Epub 2018 Aug 30. PMID: 30159645 Abstract Title:  Ursolic Acid Prevents Retinoic Acid-Induced Bone Loss in Rats. Abstract:  OBJECTIVE: To examine the effects of ursolic acid (UA) on mitigating retinoic acid (RA)-induced osteoporosis in rats.METHODS: Fifty female Sprague-Dawley rats were randomly divided into the control group (n=10) and the osteoporosis group (n=40). The 40 osteoporosis rats were induced by 75 mg/(kg•d) RA once daily for 2 weeks, and then were randomly assigned to vehicle control (model), low-, middle-, and high-dose UA [(UA-L, UA-M, UA-H; 30, 60, 120 mg/(kg•d), respectively] groups (10 rats each). UA were administered once daily to the rats from the 3rd weeks for up to 4 weeks by gavage. Bone turnover markers [serum alkaline phosphatase (ALP), osteocalcin (OCN), urine deoxypyridinoline (DPD)] and other parameters, including serum calcium (S-Ca), serum phosphorus (S-P), urine calcium (U-Ca), urine phosphorus (U-P), and bone mineral density (BMD) of the femur, 4th lumbar vertebra and tibia, bone biomechanical properties and trabecular microarchitecture, were measured.RESULTS: The osteoporosis in rats was successfully induced by RA. Compared with the model group, UA-M and UA-H significantly reversed the RA-induced changes in S-P, U-Ca, U-P, ALP, OCN and urine DPD ratio and markedly enhanced the BMD of right femur, 4th lumbar vertebra and tibia (Plt;0.05 or Plt;0.01). Further, biomechanical test and microcomputed tomography evaluation also showed that UA-H drastically improved biomechanical properties and trabecular microarchitecture (Plt;0.05 or Plt;0.01).CONCLUSION: UA could promote bone formation, increase osteoblastic activity and reduce osteoclastic activity in rats, indicating that UA might be a potential therapeutic of RA-induced acute osteoporosis. <p><a href="https://greenmedinfo.com/article/ursolic-acid-might-be-potential-therapeutic-retinoic-acid-induced-acute-osteop" target="_blank">read more</a></p> https://greenmedinfo.com/article/ursolic-acid-might-be-potential-therapeutic-retinoic-acid-induced-acute-osteop#comments Osteoporosis Ursolic Acid Osteoprotective Retinoic Acid Animal Study Fri, 02 Aug 2019 22:40:30 +0000 greenmedinfo 192676 at https://greenmedinfo.com When Carrots May Not be Good for You https://greenmedinfo.com/blog/when-carrots-may-not-be-good-you <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="When Carrots May Not Be Good For You" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/greenmedinfo/images/carrot_health_issues.jpg" /></p> <p><span style="font-size:18px;"><strong>Retinoic acid (vitamin A) found to cause inflammation in certain individuals</strong></span></p> <p>Over the years, several of my celiac and non-celiac gluten sensitive patients have reported a dry "gritty" feeling in their eyes--often along with difficulties to focus vision and mind, reddish fingertips, and other signs of active inflammation.</p> <p>On further inquiry into food changes prior to these signs and symptoms, my patients invariably cite larger than usual intake of foods high in vitamin A. Among the foods named most frequently are beef or chicken liver, carrots, sweet potatoes, pumpkin, winter squash, cantaloupe, dandelion, kale, spinach, collard greens, and a few other foods.</p><p><a href="https://greenmedinfo.com/blog/when-carrots-may-not-be-good-you" target="_blank">read more</a></p> https://greenmedinfo.com/blog/when-carrots-may-not-be-good-you#comments Celiac Disease Gluten Sensitivity Retinoic Acid Vitamin A Fri, 11 May 2012 16:44:49 +0000 ndocroth 75204 at https://greenmedinfo.com