Drug: Ciprofloxacin https://greenmedinfo.com/category/toxic-ingredients/drug-ciprofloxacin en Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2. https://greenmedinfo.com/article/ciprofloxacin-impairs-mitochondrial-dna-replication-initiation-through-inhibit PMID:  Nucleic Acids Res. 2018 Aug 31. Epub 2018 Aug 31. PMID: 30169847 Abstract Title:  Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2. Abstract:  Maintenance of topological homeostasis is vital for gene expression and genome replication in all organisms. Similar to other circular genomes, also mitochondrial DNA (mtDNA) is known to exist in various different topological forms, although their functional significance remains unknown. We report here that both known type II topoisomerases Top2α and Top2β are present in mammalian mitochondria, with especially Top2β regulating the supercoiling state of mtDNA. Loss of Top2β or its inhibition by ciprofloxacin results in accumulation of positively supercoiled mtDNA, followed by cessation of mitochondrial transcription and replication initiation, causing depletion of mtDNA copy number. These mitochondrial effects block both cell proliferation and differentiation, possibly explaining some of the side effects associated with fluoroquinolone antibiotics. Our results show for the first time the importance of topology for maintenance of mtDNA homeostasis and provide novel insight into the mitochondrial effects of fluoroquinolones. <p><a href="https://greenmedinfo.com/article/ciprofloxacin-impairs-mitochondrial-dna-replication-initiation-through-inhibit" target="_blank">read more</a></p> https://greenmedinfo.com/article/ciprofloxacin-impairs-mitochondrial-dna-replication-initiation-through-inhibit#comments Antibiotic Toxicity Mitochondrial Dysfunction Drug: Ciprofloxacin In Vitro Study Sat, 22 Sep 2018 15:09:40 +0000 greenmedinfo 171107 at https://greenmedinfo.com Natural Ear Infection Alternatives to Antibiotics Proven Safer and More Effective https://greenmedinfo.com/blog/natural-ear-infection-alternatives-antibiotics-proven-safer-and-more-effective <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2015<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="Natural Ear Infection Alternatives to Antibiotics Proven Safer and More Effective" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/ear_infection_natural_treatment.jpg" style="height: 600px; width: 600px;" /></p> <p><span style="font-size:16px;"><strong><em>According to existing scientific evidence, choosing natural, side effect-free herbal formulas to treat acute ear infection and pain over synthetic antibiotics with questionable therapeutic efficacy is a reasonable and well-founded option.</em></strong></span></p><p><a href="https://greenmedinfo.com/blog/natural-ear-infection-alternatives-antibiotics-proven-safer-and-more-effective" target="_blank">read more</a></p> https://greenmedinfo.com/blog/natural-ear-infection-alternatives-antibiotics-proven-safer-and-more-effective#comments Ear Infection anti-inflammatory Antibiotics Antimicrobial Drug: Amoxicillin Drug: Ciprofloxacin Health Guide: Essential Oils Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Tylenol Watchful Waiting Antibiotics: Ineffective Drug: Amoxicillin Drug: Ciprofloxacin ear infections Superiority of Natural Substances versus Drugs Sat, 14 Dec 2013 17:19:15 +0000 elroum 110741 at https://greenmedinfo.com