St. John&amp;#039;s Wort https://greenmedinfo.com/category/substance/St.%20John%2526%2523039%3Bs%20Wort en 20 Remedies to Kick PMS Naturally https://greenmedinfo.com/blog/20-remedies-kick-pms-naturally <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="20 Remedies to Kick PMS Naturally" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/PMS_Photo.jpg" style="width: 500px; height: 269px;" /></p><p><a href="https://greenmedinfo.com/blog/20-remedies-kick-pms-naturally" target="_blank">read more</a></p> https://greenmedinfo.com/blog/20-remedies-kick-pms-naturally#comments Calcium Eicosapentaenoic acid (EPA) Gamma-Linoleic Acid (GLA) Iron Magnesium Premenstrual syndrome Progesterone St. John&#039;s Wort Vitamin B6 Vitamin D Zinc Women's Health Calcium Eicosapentaenoic acid (EPA) gamma-linoleic acid homepathy Iron Magnesium premenstrual syndrome progesterone Vitamin B6 VITAMIN D zinc Tue, 27 May 2014 17:54:40 +0000 garynullphd 112580 at https://greenmedinfo.com Hypericum extract is superior to fluoxetine in treating depressed patients. https://greenmedinfo.com/article/hypericum-extract-superior-fluoxetine-treating-depressed-patients PMID:  Int J Neuropsychopharmacol. 2005 Jun ;8(2):215-21. Epub 2004 Sep 30. PMID: 15458612 Abstract Title:  Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo. Abstract:  Hypericum extract (HE) might be favourably active in depressed patients with reversed vegetative signs (RVS). Therefore, we performed an exploratory subgroup analysis of a three-armed study to compare HE, fluoxetine, and placebo in patients with major depressive disorder (MDD) in a 12 wk trial. A total of 135 patients were randomized to 12 wk treatment with HE LI 160 (900 mg/d), fluoxetine (20 mg/d), or placebo. Patients with RVS were defined in two steps, according to DSM-IV. First, patients with melancholy-related vegetative signs were excluded. Secondly, patients had to have at least one score of 2 for the items 22-26 of the HAMD-28 scale, which are related to hypersomnia and hyperphagia. Twenty-seven patients remained in the group. Analysis of covariance (ANCOVA) was applied using the HAMD-17 score. Secondly a chi2 test for response was performed, using the same and further an adapted criterium as in recently published studies. ANCOVA revealed a trend to a global difference. Post-hoc analysis showed a trend to superiority of HE compared to placebo and to fluoxetine, but a very large effect size for both differences. Fluoxetine was not different from placebo. The adapted response criterium showed a significant global difference as well as a significant superiority of HE over placebo and over fluoxetine. These data are based on a small sample size and must be considered tentative. A characterization of vegetative features of patients with depression could lead to an overall increased effect size in the treatment with HE. https://greenmedinfo.com/article/hypericum-extract-superior-fluoxetine-treating-depressed-patients#comments Depression St. John&#039;s Wort Antidepressive Agents Fluoxetine (trade name Prozac) Placebo Effect Phytotherapy Plant Extracts Superiority of Natural Substances versus Drugs Human Study Sun, 05 Apr 2015 18:07:55 +0000 greenmedinfo 116650 at https://greenmedinfo.com Hypericum perforatum compares favorable to fluoxetine in the treatment of mild to moderate depression. https://greenmedinfo.com/article/hypericum-perforatum-compares-favorable-fluoxetine-treatment-mild-moderate-d-0 PMID:  Rev Bras Psiquiatr. 2006 Mar ;28(1):29-32. Epub 2006 Mar 24. PMID: 16612487 Abstract Title:  Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample. Abstract:  OBJECTIVE: Hypericum perforatum has demonstrated antidepressant efficacy when compared to placebo, but comparisons with other antidepressants remain controversial. We assessed the efficacy and safety of Hypericum perforatum in comparison with fluoxetine, in a 8-week double-blind trial in patients with mild to moderate depression.METHOD: Seventy-two outpatients were randomly assigned to receive Hypericum perforatum 900 mg/day, fluoxetine 20 mg/day or placebo. Efficacy measures included the HAM-D21 scale, the Montgomery-Asberg Rating Scale, and the Clinical Global Impression. Safety was assessed with the UKU Side Effect Rating Scale.RESULTS: Intention-to-treat analysis showed no differences between the mean scores of the three groups. In the analyses of observed cases, patients receiving Hypericum perforatum had the lowest remission rates (12%, p = 0.016) compared to fluoxetine (34.6%) and placebo (45%).CONCLUSIONS: Hypericum perforatum was less efficacious than both fluoxetine and placebo. Both drugs were safe and well-tolerated. Larger trials are needed for definite conclusions. https://greenmedinfo.com/article/hypericum-perforatum-compares-favorable-fluoxetine-treatment-mild-moderate-d-0#comments Depression St. John&#039;s Wort Fluoxetine (trade name Prozac) Natural Substances Versus Drugs Phytotherapy Plant Extracts Superiority of Natural Substances versus Drugs Human Study Sun, 05 Apr 2015 18:00:11 +0000 greenmedinfo 116647 at https://greenmedinfo.com Hypericum perforatum compares favorable to fluoxetine in the treatment of mild to moderate depression. https://greenmedinfo.com/article/hypericum-perforatum-compares-favorable-fluoxetine-treatment-mild-moderate-dep PMID:  Rev Bras Psiquiatr. 2006 Mar ;28(1):29-32. Epub 2006 Mar 24. PMID: 16612487 Abstract Title:  Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression: a randomized double-blind trial in a Brazilian sample. Abstract:  OBJECTIVE: Hypericum perforatum has demonstrated antidepressant efficacy when compared to placebo, but comparisons with other antidepressants remain controversial. We assessed the efficacy and safety of Hypericum perforatum in comparison with fluoxetine, in a 8-week double-blind trial in patients with mild to moderate depression.METHOD: Seventy-two outpatients were randomly assigned to receive Hypericum perforatum 900 mg/day, fluoxetine 20 mg/day or placebo. Efficacy measures included the HAM-D21 scale, the Montgomery-Asberg Rating Scale, and the Clinical Global Impression. Safety was assessed with the UKU Side Effect Rating Scale.RESULTS: Intention-to-treat analysis showed no differences between the mean scores of the three groups. In the analyses of observed cases, patients receiving Hypericum perforatum had the lowest remission rates (12%, p = 0.016) compared to fluoxetine (34.6%) and placebo (45%).CONCLUSIONS: Hypericum perforatum was less efficacious than both fluoxetine and placebo. Both drugs were safe and well-tolerated. Larger trials are needed for definite conclusions. https://greenmedinfo.com/article/hypericum-perforatum-compares-favorable-fluoxetine-treatment-mild-moderate-dep#comments Depression St. John&#039;s Wort Fluoxetine (trade name Prozac) Natural Substances Versus Drugs Phytotherapy Plant Extracts Superiority of Natural Substances versus Drugs Human Study Sun, 05 Apr 2015 18:00:08 +0000 greenmedinfo 116646 at https://greenmedinfo.com St John's wort was significantly more effective than fluoxetine and showed a trend toward superiority over placebo https://greenmedinfo.com/article/st-johns-wort-was-significantly-more-effective-fluoxetine-and-showed-trend-tow PMID:  J Clin Psychopharmacol. 2005 Oct ;25(5):441-7. PMID: 16160619 Abstract Title:  A Double-blind, randomized trial of St John&#039;s wort, fluoxetine, and placebo in major depressive disorder. Abstract:  OBJECTIVE: This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John&#039;s wort with both placebo and fluoxetine.METHOD: After a 1-week single-blind washout, patients with major depressive disorder diagnosed by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition were randomized to 12 weeks of double-blind treatment with LI-160 St John&#039;s wort extract (900 mg/d), fluoxetine (20 mg/d), or placebo. The 17-item Hamilton Rating Scale for Depression (HAMD-17) was the primary efficacy measure, and analysis of covariance was used to compare differences in end point HAMD-17 scores across the 3 treatment groups, treating the baseline HAMD-17 as the covariate.RESULTS: One hundred thirty-five patients (57% women; mean age, 37.3 +/- 11.0; mean HAMD-17, 19.7 +/- 3.2) were randomized to double-blind treatment and were included in the intent-to-treat analyses. Analysis of covariance analyses showed lower mean HAMD-17 scores at end point in the St John&#039;s wort group (n = 45; mean +/- SD, 10.2 +/- 6.6) compared with the fluoxetine group (n = 47; 13.3 +/- 7.3; P https://greenmedinfo.com/article/st-johns-wort-was-significantly-more-effective-fluoxetine-and-showed-trend-tow#comments Depression St. John&#039;s Wort Antidepressive Agents Fluoxetine (trade name Prozac) Phytotherapy Plant Extracts Superiority of Natural Substances versus Drugs Human Study Sun, 05 Apr 2015 18:01:26 +0000 greenmedinfo 116648 at https://greenmedinfo.com The results confirm the efficacy of the three herbal active substances in elderly patients with anxiety, depression, and dementia. https://greenmedinfo.com/article/results-confirm-efficacy-three-herbal-active-substances-elderly-patients-anxie PMID:  Wien Med Wochenschr. 2015 Jun 20. Epub 2015 Jun 20. PMID: 26092515 Abstract Title:  Phytopharmaceutical treatment of anxiety, depression, and dementia in the elderly: evidence from randomized, controlled clinical trials. Abstract:  Based on subgroup analyses of randomized, controlled clinical trials, we review the efficacy of three phytopharmaceutical drugs, respectively of the corresponding active substances silexan® (WS® 1265, lavender oil) in anxiety disorders, WS® 5570 (Hypericum extract) in major depression, and EGb 761® (Ginkgo biloba extract) in Alzheimer, vascular, or mixed type dementia, in elderly patients aged ≥ 60 years.Four trials were eligible in each indication. Meta-analyses and analysesbased on pooled raw data showed that the three drugs were significantly superior to placebo in the elderly subset, and that their treatment effects reflected in the main outcome measures (Hamilton Anxiety scale, Hamilton Depression scale, Neuropsychiatric Inventory) were comparable with those observed in the original trials without age restrictions.The results confirm the efficacy of the three herbal active substances in elderly patients of ≥ 60 years of age. In anxiety, depression, and dementia, they thus represent efficacious and well-tolerated alternatives to synthetic drugs. https://greenmedinfo.com/article/results-confirm-efficacy-three-herbal-active-substances-elderly-patients-anxie#comments Anxiety Disorders Dementia Depression Ginkgo biloba Lavender: Essential Oil St. John&#039;s Wort Antidepressive Agents Meta Analysis Natural Substances Versus Drugs Plant Extracts Mon, 22 Jun 2015 16:12:45 +0000 greenmedinfo 118370 at https://greenmedinfo.com