melatonin https://greenmedinfo.com/category/keywords/melatonin en 7 Ways Melatonin Acts as a Breast Cancer Inhibitor https://greenmedinfo.com/blog/7-ways-melatonin-acts-breast-cancer-inhibitor <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2017<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p align="center"><br /> <img alt="7 Ways Melatonin Acts as a Breast Cancer Inhibitor" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/melatonin.jpeg" style="width: 601px; height: 401px;" title="Melatonin Acts as a Breast Cancer Inhibitor" /></p> <h2> 7 Ways Melatonin Acts as a Breast Cancer Inhibitor</h2> <p>For those that seek natural relief from <strong><a href="/disease/insomnia" target="_blank" title="7 Ways Melatonin Acts as a Breast Cancer Inhibitor">insomnia</a></strong>, <strong><a href="/substance/melatonin" target="_blank" title="7 Ways Melatonin Acts as a Breast Cancer Inhibitor">melatonin</a></strong> often comes to mind. Melatonin has been shown to be very effective in improving sleep issues in some individuals, but it also has many other lesser known applications.</p><p><a href="https://greenmedinfo.com/blog/7-ways-melatonin-acts-breast-cancer-inhibitor" target="_blank">read more</a></p> https://greenmedinfo.com/blog/7-ways-melatonin-acts-breast-cancer-inhibitor#comments Breast Cancer Estrogen Dominance Insomnia Melatonin anti-carcinogenic role Apoptotic Cancer Immunomodulatory protects from estrogenic effects suppression of breast cancer cells Xenobiotics Breast Cancer electromagnetic frequencies healing breast cancer insomnia melatonin Xenoestrogens Mon, 07 Jan 2013 19:52:29 +0000 DrV 80542 at https://greenmedinfo.com Antioxidants & Chemotherapy: the Cruelest Lie Ever Told https://greenmedinfo.com/blog/antioxidants-chemotherapy-cruelest-lie-ever-told <p class="rtecenter"><span style="font-family:verdana,geneva,sans-serif;"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/AntioxidantsChemotherapytheCruelestLieEverTold.jpg" style="width: 600px; height: 316px;" title="Antioxidants &amp; Chemotherapy: the Cruelest Lie Ever Told" /></span></p> <p><span style="font-size:18px;"><strong>Cancer patients are suffering from devastating side effects of chemotherapy, when antioxidants may be the answer</strong></span></p><p><a href="https://greenmedinfo.com/blog/antioxidants-chemotherapy-cruelest-lie-ever-told" target="_blank">read more</a></p> https://greenmedinfo.com/blog/antioxidants-chemotherapy-cruelest-lie-ever-told#comments Antioxidant formulas Cancers Chemotherapy-Induced Kidney Damage Chemotherapy-Induced Toxicity Glutathione Melatonin Nausea: Chemotherapy-Induced Vitamin E Chemical and Drug Toxicity Chemotherapy Chemotherapy Antioxidant formulas Cancer chemo Chemotherapy Induced Toxicity glutathione melatonin VITAMIN E Mon, 31 Jul 2017 23:08:20 +0000 Linda Woolven and Ted Snider 151027 at https://greenmedinfo.com Breast Cancer and Leptin – How to Become More Proactive in Prevention https://greenmedinfo.com/blog/breast-cancer-and-leptin-how-become-more-proactive-prevention <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2014<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><h1 class="rtecenter"> <img alt="Breast Cancer and Leptin – How to Become More Proactive in Prevention" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/Breast_Cancer_and_Leptin.jpg" style="width: 499px; height: 375px;" /></h1> <p>Are you simply&nbsp;lucky&nbsp;if you don't get breast cancer? After all, 1 in 8 women will get it. While there is a lot we do not know about <strong><a href="/disease/breast-cancer">breast cancer</a></strong>, there is a lot we DO know about it. Irradiating our breasts with x-ray <strong><a href="http://realfoodforager.com/3-risks-your-doctor-wont-tell-you-about-mammography/" rel="nofollow" target="_blank">mammography</a></strong>&nbsp;each and every year is a failed screening method. This does nothing to prevent breast cancer. &nbsp;In fact, it adds to the harmful exposure of sensitive breast tissue to ionizing radiation.</p><p><a href="https://greenmedinfo.com/blog/breast-cancer-and-leptin-how-become-more-proactive-prevention" target="_blank">read more</a></p> https://greenmedinfo.com/blog/breast-cancer-and-leptin-how-become-more-proactive-prevention#comments Breast Cancer Estrogen Dominance Melatonin Health Guide: Breast Cancer Phthalates Polyethylene terephthalate (PET) xeno-estrogens Aromatase Inhibitor Breast Cancer estrogen leptin mammography melatonin Stress Wed, 28 May 2014 22:31:24 +0000 jill@realfoodforager.com 112592 at https://greenmedinfo.com Do You Have NHF Nutritional Supplement Insurance? https://greenmedinfo.com/blog/do-you-have-nhf-nutritional-supplement-insurance <p class="rtecenter" dir="ltr"><br /> <img alt="Do You Have NHF Nutritional Supplement Insurance?" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/stebu/images/87336351-c338-4f21-8a85-31f446d677dc.jpg" style="width: 450px; height: 204px;" /></p> <p dir="ltr">Do you go to a chiropractor? National Health Federation made that possible back in the 50s.</p> <p dir="ltr">Is an acupuncturist part of your healthcare team? NHF fought for your right to use alternative practitioners ...</p> <p dir="ltr">Do you drink water free of poisonous fluoridation? You have the NHF to thank for that.</p> <p dir="ltr">Do you use supplements? We made that possible too ...</p> <p dir="ltr">Do you have the insurance that only NHF can provide that this will continue?</p> <p dir="ltr">If not you are exposed and vulnerable!</p><p><a href="https://greenmedinfo.com/blog/do-you-have-nhf-nutritional-supplement-insurance" target="_blank">read more</a></p> https://greenmedinfo.com/blog/do-you-have-nhf-nutritional-supplement-insurance#comments Ebola Melatonin Vitamin C Vitamin D codex alimentarius Dick Durbin Ebola FAO Food and Agriculture Organization Insurance melatonin National Health Federation NHF Scott Tips Vitamin C VITAMIN D Mon, 20 Oct 2014 23:29:31 +0000 katacarroll 115081 at https://greenmedinfo.com Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin. https://greenmedinfo.com/article/increase-motility-and-invasiveness-mcf7-cancer-cells-induced-nicotine-abolishe n/a PMID:  J Pineal Res. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29338098 Abstract Title:  Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. Abstract:  Through activation of the ERK pathway nicotine, in both normal MCF-10A and low malignant breast cancer cells (MCF7), promotes increased motility and invasiveness. Melatonin antagonizes both these effects by inhibiting almost completely ERK phosphorylation. As melatonin has no effect on not-stimulated cells, it is likely that melatonin can counteract ERK-activation only downstream of nicotine-induced activation. This finding suggests that melatonin hampers ERK phosphorylation presumably by targeting a still unknown intermediate factor that connects nicotine stimulation to ERK phosphorylation. Furthermore, downstream of ERK activation, melatonin significantly reduces Fascin and Calpain activation while restoring normal Vinculin levels. Melatonin also counteracts nicotine effects by reshaping the overall cytoskeleton architecture and abolishing invasive membrane protrusion. In addition, melatonin decreases nicotine-dependent ROCK1/ROCK2 activation, thus further inhibiting cell contractility and motility. Melatonin actions are most likely attributable to ERK inhibition, although melatonin could display other ERK-independent effects, namely through a direct modulation of additional molecular and structural factors, including Coronin, Cofilin and cytoskeleton components. This article is protected by copyright. All rights reserved. https://greenmedinfo.com/article/increase-motility-and-invasiveness-mcf7-cancer-cells-induced-nicotine-abolishe#comments Breast Cancer Melatonin Nicotine/Tobacco Toxicity Anti-metastatic Anti-metastatic Breast Cancer melatonin Nicotine/Tobacco Toxicity In Vitro Study Fri, 19 Jan 2018 17:03:26 +0000 greenmedinfo 158590 at https://greenmedinfo.com Ladies, Ditch the Bra https://greenmedinfo.com/blog/ladies-ditch-bra-1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/FearlessParent_DitchtheBra_Featured.png" style="width: 645px; height: 400px;" /></p> <p class="rtecenter">Originally published on <strong><a href="http://fearlessparent.org/catch-good-ditch-bra/">Fearless Parent</a></strong></p> <p><strong><span style="font-size:24px;"><em>Evidence of a relationship between bras and breast cancer may rethink the societal convention of wearing bras.</em></span></strong></p> <p>I realize it may feel some combination of uncomfortable, unprofessional, or unnecessarily provocative. Societal convention has most of us trussing up before going out.</p> <p>If you are reading this at home, do me a favor and unhook. Then keep reading.</p> <h1> There's Some Evidence of a Relationship Between Bras and Breast Cancer.</h1> <p>Yes, seriously.</p> <p><strong>Dressed To Kill: The Link Between Breast Cancer and Bras</strong></p><p><a href="https://greenmedinfo.com/blog/ladies-ditch-bra-1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/ladies-ditch-bra-1#comments Breast Cancer Melatonin Wearing A Brassiere Braless Bras Breast Cancer melatonin underwires Sun, 10 Mar 2019 20:35:33 +0000 louisehabakus 113185 at https://greenmedinfo.com Melatonin administration may lower the risk of relapse triggered by cues in cocaine-experienced animals. https://greenmedinfo.com/article/melatonin-administration-may-lower-risk-relapse-triggered-cues-cocaine-experie n/a PMID:  Psychopharmacology (Berl). 2017 Feb 28. Epub 2017 Feb 28. PMID: 28246896 Abstract Title:  Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats. Abstract:  RATIONALE: Melatonin is a hormone involved in the entrainment of circadian rhythms, which appears dysregulated in drug users. Further, it has been demonstrated that melatonin can modulate the reinforcing effects of several drugs of abuse and may therefore play a role in drug addiction. OBJECTIVE: Here, we investigated whether administration of melatonin reduces relapse-like behavior and the motivation to seek cocaine in rats. METHODS: Male Sprague-Dawley rats were submitted to long-term cocaine self-administration training. Thereafter, melatonin effects were assessed on: (1) the motivation to work for cocaine in the break point test, (2) the relapse-like behavior in the cue-induced reinstatement test, (3) the distance traveled in the open field test, and (4) sucrose preference in a two-bottle choice paradigm. Melatonin, 25 or 50 mg/kg, was injected 3-4 h after the dark phase onset, 30 min prior to each test. RESULTS: Both doses of melatonin decreased the number of active pokes in both break point and cue-induced reinstatement tests, demonstrating that melatonin can reduce the cocaine-seeking behavior and the motivation to work for cocaine. Administration of the higher dose of this hormone, however, significantly reduced the number of inactive pokes during the cue-induced reinstatement test and tended to reduce animals&#039; locomotor activity in the open field test. Sucrose preference was unchanged in both vehicle- and melatonin-treated animal groups. CONCLUSIONS: Our data suggest that melatonin administration may lower the risk of relapse triggered by cues in cocaine-experienced animals. https://greenmedinfo.com/article/melatonin-administration-may-lower-risk-relapse-triggered-cues-cocaine-experie#comments Cocaine Addiction Cocaine Withdrawal Melatonin Cocaine Addiction Cocaine Withdrawal melatonin Animal Study Fri, 03 Mar 2017 23:34:00 +0000 greenmedinfo 144381 at https://greenmedinfo.com Melatonin could be used as an adjuvant agent with rapamycin in head and neck cancers. https://greenmedinfo.com/article/melatonin-could-be-used-adjuvant-agent-rapamycin-head-and-neck-cancers n/a PMID:  J Pineal Res. 2017 Dec 16. Epub 2017 Dec 16. PMID: 29247557 Abstract Title:  Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. Abstract:  Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of treatment with the mTOR inhibitor rapamycin is often limited by chemoresistance. Melatonin suppresses neoplastic growth via different mechanisms in a variety of tumours. In this study, we aimed to elucidate the effects of melatonin on rapamycin-induced HNSCC cell death and to identify potential cross-talk pathways. We analysed the dose-dependent effects of melatonin in rapamycin-treated HNSCC cell lines (Cal-27 and SCC-9). These cells were treated with 0.1, 0.5 or 1 mmol/L melatonin combined with 20 nM rapamycin. We further examined the potential synergistic effects of melatonin with rapamycin in Cal-27 xenograft mice. Relationships between inhibition of the mTOR pathway, reactive oxygen species (ROS), and apoptosis and mitophagy reportedly increased the cytotoxic effects of rapamycin in HNSCC. Our results demonstrated that combined treatment with rapamycin and melatonin blocked the negative feedback loop from the specific downstream effector of mTOR activation S6K1 to Akt signalling, which decreased cell viability, proliferation and clonogenic capacity. Interestingly, combined treatment with rapamycin and melatonin-induced changes in mitochondrial function, which were associated with increased ROS production, increasing apoptosis and mitophagy. This led to increase cell death and cellular differentiation. Our data further indicated that melatoninadministration reduced rapamycin-associated toxicity to healthy cells. Overall, our findings suggested that melatonin could be used as an adjuvant agent with rapamycin, improving effectiveness while minimizing its side effects. https://greenmedinfo.com/article/melatonin-could-be-used-adjuvant-agent-rapamycin-head-and-neck-cancers#comments Head and Neck Cancer Melatonin Chemoprotective Agents Chemotherapeutic Chemoprotective Agents Chemotherapeutic Head and Neck Cancer melatonin Natural Substance/Drug Synergy In Vitro Study Fri, 19 Jan 2018 00:57:45 +0000 greenmedinfo 158579 at https://greenmedinfo.com Melatonin could have an effect on body weight. https://greenmedinfo.com/article/melatonin-could-have-effect-body-weight n/a PMID:  Curr Pharm Des. 2016 Nov 29. Epub 2016 Nov 29. PMID: 27897121 Abstract Title:  Role of melatonin in body weight: A systematic review and meta-analysis. Abstract:  BACKGROUND: Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects. METHODS: First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature. RESULTS: We included 7 clinical trials with a total of 244 patients. All studies were parallel clinical trials conducted at the clinic. Evaluating standardized mean difference (SMD) using Cohen&#039;s method shows that none of the included studies have found a strong and significant effect of melatonin on body weight. However, some have reported decreasing or increasing effect of melatonin on body weight. We pooled SMDs using random effects (DerSimonian and Laird). Polled SMD was still not significant SMD (95% CI) = 0.09(-0.17-0.34), with lack of heterogeneity I2=0.0%, p=0.66. CONCLUSION: We concluded that once the standard treatment had increasing effect on body weight, melatonin could be able to slightly diminish this effect and vice versa. Subgroup analysis showed that melatonin was more effective in child and adolescents. According to the results hypothesis of the buffering role of melatonin on body weight fluctuations can be proposed. https://greenmedinfo.com/article/melatonin-could-have-effect-body-weight#comments Melatonin Overweight insomnia melatonin Meta Analysis overweight sleep Weight Loss weight-gain Review Thu, 01 Dec 2016 19:02:16 +0000 greenmedinfo 139717 at https://greenmedinfo.com Melatonin exposure improves liver tissue damage caused by arsenic exposure. https://greenmedinfo.com/article/melatonin-exposure-improves-liver-tissue-damage-caused-arsenic-exposure n/a PMID:  Ulus Cerrahi Derg. 2016 ;32(4):233-237. Epub 2016 Oct 27. PMID: 28149117 Abstract Title:  The effects of melatonin on liver functions in arsenic-induced liver damage. Abstract:  OBJECTIVE: Arsenic exposure is increasing in communities due to environmental pollution and industrial development. Arsenic is toxic to organ systems because it causes oxidative stress, enzymatic inhibition, and damage to protein structures. The liver, for example, is an organ that may be damaged by arsenic, and this damage may cause various clinical conditions like hepatic failure or cancer. Melatonin is a hormone that acts like an antioxidant, an anti-inflammatory agent, and a cytoprotective agent. In this study, we aimed to evaluate melatonin&#039;s protective effects on livers damaged by arsenic toxicity. MATERIALS AND METHODS: Twenty-four Sprague-Dawley male rats were classified into three groups: a control group, an arsenic applied group, and an arsenic plus 10 mg/kg melatonin applied group. At the end of the fifteen-day experiment, the rats were sacrificed. Albumin, interleukin-6 (IL-6), total protein, alanine transaminase, aspartate transaminase, macrophage migration inhibitory factor, and monocyte chemotactic protein-1 measurements were obtained. RESULTS: In rats with liver damage due to arsenic exposure, melatonin administration significantly decreased the levels of IL-6, macrophage migration inhibitory factor, and monocyte chemotactic protein-1 (p&lt;0.001, p=0.02 and p=0.04, respectively). CONCLUSION: After evaluating liver enzymes and inflammatory markers, this study determined that melatonin exposure improves liver tissue damage caused by arsenic exposure, with the degree of improvement varying based on the levels of arsenic exposure. https://greenmedinfo.com/article/melatonin-exposure-improves-liver-tissue-damage-caused-arsenic-exposure#comments Arsenic Poisoning Melatonin Arsenic Hepatoprotective Arsenic Poisoning Hepatoprotective melatonin Animal Study Wed, 15 Feb 2017 02:12:45 +0000 greenmedinfo 143566 at https://greenmedinfo.com Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats. https://greenmedinfo.com/article/melatonin-produces-rapid-onset-and-prolonged-efficacy-reducing-depression-beha n/a PMID:  Neurosci Lett. 2017 Mar 6 ;642:129-135. Epub 2017 Jan 9. PMID: 28082153 Abstract Title:  Melatonin produces a rapid onset and prolonged efficacy in reducing depression-like behaviors in adult rats exposed to chronic unpredictable mild stress. Abstract:  The present study was aimed at evaluating the rapidity and duration of melatonin as an antidepressant in a rat model of depression. The rats were subjected to a six-week period of unpredictable mild stress followed by melatonin treatment. Three groups of rats were included in this study: Controls (CON - no stress exposure), Chronic Unpredictable Mild Stress (CUS) and CUS followed by melatonin (MT). Stressors consisted of exposure to rotation on a shaker, placement in a chamber maintained at 4°C, lights off for 3h, lights on overnight, exposure to an aversive odor, 45° tilted cages, food and water deprivation and crowding and isolated housing. Subsequently, the saline vehicle (CUS) or melatonin was administered at a dose of 10mg/kg for 14days period. Body weight and behavioral tests were used to evaluate depression-like behavior and its recovery following melatonin treatment. While body weight increases were significantly lower in rats exposed to CUS versus CON, body weights of the MT group increased significantly following melatonin treatment as compared with the CUS group. Withregard to results obtained with behavioral assays indicative of depression, rapid and long-term functional recoveries in depression were observed in the MT as compared to the CUS group. The results indicate that not only does melatonin induce an antidepressant-like action within this rat model of depression, but does so with a rapid onset and prolonged efficacy. As most current treatments for depression require an extended period of administration, our current results suggest that melatonin may prove to be a particularly effect agent to promote a rapid onset and prolonged behavioral benefitsin the treatment of depression. https://greenmedinfo.com/article/melatonin-produces-rapid-onset-and-prolonged-efficacy-reducing-depression-beha#comments Depression Melatonin Antidepressive Agents Antidepressive Agents Depression melatonin Animal Study Fri, 21 Jul 2017 06:06:51 +0000 greenmedinfo 150758 at https://greenmedinfo.com Melatonin promotes brain-derived neurotrophic factor expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia. https://greenmedinfo.com/article/melatonin-promotes-brain-derived-neurotrophic-factor-expression-and-anti-apopt n/a PMID:  Med Sci Monit. 2017 Dec 16 ;23:5951-5959. Epub 2017 Dec 16. PMID: 29247156 Abstract Title:  Melatonin Promotes Brain-Derived Neurotrophic Factor (BDNF) Expression and Anti-Apoptotic Effects in Neonatal Hemolytic Hyperbilirubinemia via a Phospholipase (PLC)-Mediated Mechanism. Abstract:  BACKGROUND Melatonin therapy shows positive effects on neuroprotective factor brain-derived neurotrophic factor (BDNF) expression and neuronal apoptosis in neonatal hemolytic hyperbilirubinemia. We hypothesized that melatonin promotes BDNF expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia through a phospholipase (PLC)-mediated mechanism. MATERIAL AND METHODS A phenylhydrazine hydrochloride (PHZ)-induced neonatal hemolytic hyperbilirubinemia model was constructed in neonatal rats. Four experimental groups - a control group (n=30), a PHZ group (n=30), a PHZ + melatonin group (n=30), and a PHZ + melatonin+U73122 (a PLC inhibitor) group (n=30) - were constructed. Trunk blood was assayed for serum hemoglobin, hematocrit, total and direct bilirubin, BDNF, S100B, and tau protein levels. Brain tissue levels of neuronal apoptosis, BDNF expression, PLC activity, IP3 content, phospho- and total Ca2+/calmodulin-dependent protein kinase type IV (CaMKIV) expression, and phospho- and total cAMP response element binding protein (CREB) expression were also assayed. RESULTS PHZ-induced hemolytic hyperbilirubinemia was validated by significantly decreased serum hemoglobin and hematocrit as well as significantly increased total and direct serum bilirubin (p&lt;0.05). Neonatal bilirubin-induced neurotoxicity was validated by significantly decreased serum BDNF, brain BDNF, and serum S100B, along with significantly increased serum tau protein (p&lt;0.05). PHZ-induced hemolytic hyperbilirubinemia significantly decreased serum BDNF, brain BDNF, and PLC/IP3/Ca2+ pathway activation while increasing neuronal apoptosis levels (p&lt;0.05), all of which were partially rescued by melatonin therapy (p&lt;0.05). Pre-treatment with the PLC inhibitor U73122 largely abolished the positive effects of melatonin on PLC/IP3/Ca2+ pathway activation, downstream BDNF levels, and neuronal apoptosis (p&lt;0.05). CONCLUSIONS Promotion of BDNF expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia by melatonin largely operates via a PLC-mediated mechanism. https://greenmedinfo.com/article/melatonin-promotes-brain-derived-neurotrophic-factor-expression-and-anti-apopt#comments Hyperbilirubinemia: Hereditary Melatonin Anti-Apoptotic Brain-derived neurotrophic factor modulator Anti-Apoptotic Brain-derived neurotrophic factor modulator Hyperbilirubinemia: Hereditary melatonin Animal Study Fri, 19 Jan 2018 01:19:50 +0000 greenmedinfo 158582 at https://greenmedinfo.com Novel agonists of melatonin receptors as promising hypotensive and neuroprotective agents for therapy of glaucoma. https://greenmedinfo.com/article/novel-agonists-melatonin-receptors-promising-hypotensive-and-neuroprotective-a n/a PMID:  Biomed Khim. 2017 Jan ;63(1):75-80. PMID: 28251954 Abstract Title:  [Novel agonists of melatonin receptors as promising hypotensive and neuroprotective agents for therapy of glaucoma]. Abstract:  Melatonin is a pineal hormone that has a capacity to lower intraocular pressure; it exhibits neuroprotective and antioxidant properties that make it possible to use melatonin in the therapy of glaucoma. Analogs of melatonin having affinity to melatonin receptors are promising candidates for application as antiglaucomatous drugs. Chemical modification of the melatonin structure can in-crease efficiency, bioavailability and selectivity of these analogs. We have designed and synthe-sized a number of new 2-oxindole derivatives - ligands of melatonin MT3 subtype receptors that displayed ability to lower intraocular pressure in normotensive rabbits and high antioxidant activity against hydroxyl radical and superoxide anion-radical. The antioxidant activity of new ligands was several times higher than one of melatonin that makes them prospective therapeutic tools for the diseases that include oxidative stress. The maximal hypotensive effect of analogs was comparable to that of melatonin itself but prolonged. Combination of these properties gives an opportunity of using the presented melatonin analogs in complex therapy of glaucoma. https://greenmedinfo.com/article/novel-agonists-melatonin-receptors-promising-hypotensive-and-neuroprotective-a#comments Glaucoma Melatonin Antihypertensive Agents Antioxidants Neuroprotective Agents Antihypertensive Agents Antioxidants glaucoma melatonin Neuroprotective Agents In Vitro Study Fri, 03 Mar 2017 22:51:55 +0000 greenmedinfo 144377 at https://greenmedinfo.com Reason Behind Disturbed Sleep Found in 60% of Pineal Glands https://greenmedinfo.com/blog/reason-behind-disturbed-sleep-found-60-pineal-glands <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/jarret@greenmedinfo.com/images/Untitled%20design-5%20copy(2).png" style="width: 600px; height: 600px;" /></p> <p><em style="letter-spacing: 0px; font-size: 18px;"><strong>Is your pineal gland, the "seat of the soul" that controls sleep rhythms, turning to stone? Over 60% of people unknowingly suffer from this condition.</strong></em></p> <p><span style="letter-spacing: 0px;">A recent analysis found over 60% of people have calcification of the pineal gland, which produces the hormone melatonin regulating sleep-wake cycles. Calcification associates with melatonin decline, health issues.</span></p> <p><span style="font-size:18px;"><strong>The Calcifying Effects of Fluoride on the Pineal Gland</strong></span></p><p><a href="https://greenmedinfo.com/blog/reason-behind-disturbed-sleep-found-60-pineal-glands" target="_blank">read more</a></p> https://greenmedinfo.com/blog/reason-behind-disturbed-sleep-found-60-pineal-glands#comments Alzheimer Melatonin Pineal Gland Calcification Health Guide: Alzheimer's Health Guide: Chemical Exposures Health Guide: Food-Brain Connection Health Guide: Oral Health Melatonin Interference Sleep Deprivation melatonin pineal gland sleep Thu, 11 Jan 2024 19:05:21 +0000 GMI reporter 286375 at https://greenmedinfo.com The current meta-analysis supports the use of melatonin for anti-nociception. https://greenmedinfo.com/article/current-meta-analysis-supports-use-melatonin-anti-nociception n/a PMID:  Oncotarget. 2017 Nov 21 ;8(59):100582-100592. Epub 2017 Oct 5. PMID: 29246003 Abstract Title:  Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis. Abstract:  Melatonin is an important hormone for regulating mammalian circadian biology and cellular homeostasis. Recent evidence has shown that melatonin exerts anti-nociception effects in both animals and humans. However, according to clinical trials, the anti-nociception effects of melatonin are still controversial. The aim of this meta-analysis was to investigate the anti-nociception effects of melatonin premedication. The primary outcome was the effects of melatonin on pain intensity. The secondary outcomes included the number of patients with analgesic requirements, total analgesic consumption, and brain-derived neurotrophic factor (BDNF) levels. In total, 19 studies were included in the current meta-analysis. The pooling data show that melatonin significantly decreased the pain intensity, as evidenced by the pain scores. Moreover, melatonin administration also reduced the proportion of patients with analgesic requirements and BDNF levels. However, the effects of melatonin on total analgesic consumption still require further confirmation. Collectively, the current meta-analysis supports the use of melatonin for anti-nociception. https://greenmedinfo.com/article/current-meta-analysis-supports-use-melatonin-anti-nociception#comments Chronic Pain Melatonin Antinoceceptive Brain-derived neurotrophic factor modulator Antinoceceptive Brain-derived neurotrophic factor modulator Chronic Pain melatonin Meta Analysis Review Fri, 19 Jan 2018 14:40:04 +0000 greenmedinfo 158587 at https://greenmedinfo.com