pine bark extract https://greenmedinfo.com/category/keywords/pine-bark-extract en P. eldarica could be considered as a potential cytotoxic candidate. https://greenmedinfo.com/article/p-eldarica-could-be-considered-potential-cytotoxic-candidate n/a PMID:  Res Pharm Sci. 2016 Dec ;11(6):476-483. PMID: 28003841 Abstract Title:  Cytotoxic effects of Pinus eldarica essential oil and extracts on HeLa and MCF-7 cell lines. Abstract:  Several attempts have so far been made in the search of new anticancer agents of plant origin. Some studies have reported that different species of Pine genus possess cytotoxic activities against various cancer cell lines. In the present study, we evaluated the cytotoxic effects of Pinus eldarica bark and leaf extracts or leaf essential oil on HeLa and MCF-7 tumor cell lines. Hydroalcoholic and phenolic extracts and the essential oil of plant were prepared. Total phenolic contents of the extracts were measured using Folin-Ciocalteu reagent. Essential oil components were determined by gas chromatography-mass spectroscopy (GC-MS). Cytotoxic activity of the extracts and essential oil against HeLa and MCF-7 tumor cell lines were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The polyphenolic content of hydroalcoholic and phenolic extracts of the bark and hydroalcoholic extract of the leaf were 48.31%, 47.2%, and 8.47%, respectively. According to the GC-MS analysis, the major components of the leaf oil of P. eldarica were:β -caryophyllene (14.8%), germacrene D (12.9%), α-terpinenyl acetate (8.15%), α -pinene (5.7%), and -α humulene (5.9%). Bark extracts and leaf essential oil of P. eldarica significantly reduced the viability of both HeLa and MCF-7 cells in a concentration dependent manner. However, leaf extractshowed less inhibitory effects against both cell lines. The essential oil of P. eldarica was more cytotoxic than its hydroalcoholic and phenolic extracts. The terpenes and phenolic compounds were probably responsible for cytotoxicity of P. eldarica. Therefore, P. eldarica might have a good potentialfor active anticancer agents. https://greenmedinfo.com/article/p-eldarica-could-be-considered-potential-cytotoxic-candidate#comments Breast Cancer Cervical Cancer Pine Bark Extract Cytotoxic Breast Cancer Cancer Cervical Cancer Cytotoxic Essential Oils pine bark extract Plant Extracts In Vitro Study Mon, 02 Jan 2017 23:59:32 +0000 greenmedinfo 141321 at https://greenmedinfo.com Pine Bark Extract May Solve Antidepressant-Induced Sexual Dysfunction https://greenmedinfo.com/blog/pine-bark-extract-may-solve-antidepressant-induced-sexual-dysfunction <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2020<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Pine_Bark_Extract_May_Solve_Antidepressant-Induced_Sexual_Dysfunction-GreenMedInfo.jpg" /></p> <p><span style="font-size:18px;"><em><strong>Antidepressant medication has been linked to a number of side effects, including sexual dysfunction. Researchers from Slovakia highlighted the potential of the extract from the <a href="/substance/pine-bark-extract" rel="dofollow" target="_blank">bark of pine</a> trees -- specifically Pycnogenol, a patented extract from the French maritime pine tree -- as a solution to common bedroom woes</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/pine-bark-extract-may-solve-antidepressant-induced-sexual-dysfunction" target="_blank">read more</a></p> https://greenmedinfo.com/blog/pine-bark-extract-may-solve-antidepressant-induced-sexual-dysfunction#comments Depression Hemorrhoids Oxidative Stress Pine Bark Extract Polyphenols Pycnogenol (Pine Bark) Sexual Dysfunction Health Guide: Herbs and Traditional Knowledge Selective Serotonin Reuptake Inhibitors (SSRIs) herbalism natural remedies pine bark extract Thu, 30 Jan 2020 23:17:41 +0000 GMI Research Group 210021 at https://greenmedinfo.com These findings suggest procyanidins can be used to mitigate osteoarthritis pathogenesis. https://greenmedinfo.com/article/these-findings-suggest-procyanidins-can-be-used-mitigate-osteoarthritis-pathog n/a PMID:  Int J Mol Sci. 2016 Dec 9 ;17(12). Epub 2016 Dec 9. PMID: 27941690 Abstract Title:  Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling. Abstract:  Procyanidins are a family of plant metabolites that have been suggested to mitigate osteoarthritis pathogenesis in mice. However, the underlying mechanism is largely unknown. This study aimed to determine whether procyanidins mitigate traumatic injury-induced osteoarthritis (OA) disease progression, and whether procyanidins exert a chondroprotective effect by, at least in part, suppressing vascular endothelial growth factor signaling. Procyanidins (extracts from pine bark), orally administered to mice subjected to surgery for destabilization of the medial meniscus, significantly slowed OA disease progression. Real-time polymerase chain reaction revealed that procyanidin treatment reduced expression of vascular endothelial growth factor and effectors in OA pathogenesis that are regulated by vascular endothelial growth factor. Procyanidin-suppressed vascular endothelial growth factor expression was correlated with reduced phosphorylation of vascular endothelial growth factor receptor 2 in human OA primary chondrocytes. Moreover, components of procyanidins, procyanidin B2 and procyanidin B3 exerted effects similar to those of total procyanidins in mitigating the OA-related gene expression profile in the primary culture of human OA chondrocytes in the presence of vascular endothelial growth factor. Together, these findings suggest procyanidins mitigate OA pathogenesis, which is mediated, at least in part, by suppressing vascular endothelial growth factor signaling. https://greenmedinfo.com/article/these-findings-suggest-procyanidins-can-be-used-mitigate-osteoarthritis-pathog#comments Osteoarthritis Pine Bark Extract Chondroprotective Vascular Endothelial Growth Factor Inhibitors Chondroprotective osteoarthritis pine bark extract Procyanidins Vascular Endothelial Growth Factor Inhibitors Animal Study Tue, 03 Jan 2017 00:35:11 +0000 greenmedinfo 141332 at https://greenmedinfo.com