Pioglitazone (trade Name Actos) https://greenmedinfo.com/category/toxic-ingredients/Pioglitazone%20%28trade%20name%20Actos%29 en Several drugs are associated with weight change of varying magnitudes. https://greenmedinfo.com/article/several-drugs-are-associated-weight-change-varying-magnitudes PMID:  J Clin Endocrinol Metab. 2015 Feb ;100(2):363-70. Epub 2015 Jan 15. PMID: 25590213 Abstract Title:  Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis. Abstract:  CONTEXT: Various drugs affect body weight as a side effect.OBJECTIVE: We conducted this systematic review and meta-analysis to summarize the evidence about commonly prescribed drugs and their association with weight change.DATA SOURCES: MEDLINE, DARE, and the Cochrane Database of Systematic Reviews were searched to identify published systematic reviews as a source for trials.STUDY SELECTION: We included randomized trials that compared an a priori selected list of drugs to placebo and measured weight change.DATA EXTRACTION: We extracted data in duplicate and assessed the methodological quality using the Cochrane risk of bias tool.RESULTS: We included 257 randomized trials (54 different drugs; 84 696 patients enrolled). Weight gain was associated with the use of amitriptyline (1.8 kg), mirtazapine (1.5 kg), olanzapine (2.4 kg), quetiapine (1.1 kg), risperidone (0.8 kg), gabapentin (2.2 kg), tolbutamide (2.8 kg), pioglitazone (2.6 kg), glimepiride (2.1 kg), gliclazide (1.8 kg), glyburide (2.6 kg), glipizide (2.2 kg), sitagliptin (0.55 kg), and nateglinide (0.3 kg). Weight loss was associated with the use of metformin (1.1 kg), acarbose (0.4 kg), miglitol (0.7 kg), pramlintide (2.3 kg), liraglutide (1.7 kg), exenatide (1.2 kg), zonisamide (7.7 kg), topiramate (3.8 kg), bupropion (1.3 kg), and fluoxetine (1.3 kg). For many other remaining drugs (including antihypertensives and antihistamines), the weight change was either statistically nonsignificant or supported by very low-quality evidence.CONCLUSIONS: Several drugs are associated with weight change of varying magnitude. Data are provided to guide the choice of drug when several options exist and institute preemptive weight loss strategies when obesogenic drugs are prescribed. https://greenmedinfo.com/article/several-drugs-are-associated-weight-change-varying-magnitudes#comments Weight Gain: Drug-Induced Weight Problems: Drug-Induced Glipizide Glyburide Mirtazapine Olanzapine Pioglitazone (trade Name Actos) Quetiapine Risperidone Meta Analysis Risk Factors Weight Loss Review Thu, 11 Jun 2015 21:01:41 +0000 greenmedinfo 118259 at https://greenmedinfo.com The Dangers of GMO Insulin for Type 2 Diabetics No One Talks About https://greenmedinfo.com/blog/research-insulin-kills-diabetics-natural-substances-heal-them-1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2018<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter" dir="ltr"><img alt="The Dark Side of GMO Insulin for Type 2 Diabetics No One Talks About" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/Sayer Ji/images/gmo_insulin_diabetics_greenmedinfo.jpg" style="letter-spacing: 0px; width: 600px; height: 400px;" /></p> <p dir="ltr"><span style="font-size:22px;"><strong><em>A growing body of concerning research indicates that conventional medicine's standard of care for type 2 diabetes, including synthetic insulin and oral anti-diabetic drugs, may actually <u>increase morbidity and mortality</u>. On the other hand, recently validated traditional approaches relying on plant-based medicines may greatly mitigate the global diabetes epidemic.&nbsp;</em></strong></span></p><p><a href="https://greenmedinfo.com/blog/research-insulin-kills-diabetics-natural-substances-heal-them-1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/research-insulin-kills-diabetics-natural-substances-heal-them-1#comments Blood Sugar Problems C-Reactive Protein: Diabetes-Associated Curcumin Diabetes Diabetes Mellitus: Type 1 Diabetes Mellitus: Type 2 Diabetes Mellitus: Type 2: Prevention Insulin Resistance Turmeric Anti-diabetic drugs Health Guide: Turmeric Insulin Metformin Pioglitazone (trade Name Actos) Sun, 28 Jan 2018 15:52:19 +0000 GMI Research Group 115312 at https://greenmedinfo.com This study demonstrates protective effect of thymoquinone against HFD-induced MetS on rats which might have been mediated via PPAR mechanism. https://greenmedinfo.com/article/study-demonstrates-protective-effect-thymoquinone-against-hfd-induced-mets-rat PMID:  Eur J Nutr. 2015 Oct ;54(7):1117-27. Epub 2014 Oct 28. PMID: 25347965 Abstract Title:  Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats. Abstract:  PURPOSE: Thymoquinone (TQ), a bioactive constituent of Nigella sativa (Linn.) seed, which is commonly used as a spice in Asian food, has been reported to possess a wide range of biological effects. The present study evaluated the effect of TQ on high-fructose diet (HFD)-induced metabolic syndrome (MetS) in male Wistar rats.METHODS: MetS was induced by 60 % HFD over 42 days. TQ (25, 50 and 100 mg/kg, p.o. once daily) was administered along with HFD for 42 days. Pioglitazone (10 mg/kg, p.o. once daily) was used as a standard drug. Plasma glucose, triglycerides, total cholesterol and HDL-cholesterol were estimated on days 0 and 42. Change in bloodpressure, oral glucose tolerance and insulin resistance were measured. Hepatic thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase levels were estimated as measures of hepatic oxidative stress. Hepatic mRNA of PPAR-α and PPAR-γ was also studied.RESULTS: TQ prevented the characteristic features of HFD-induced MetS, such as hyperglycaemia, hypertriglyceridemia, hypercholesterolaemia and elevated systolic blood pressure. TQ also prevented impaired glucose tolerance and insulin resistance. It also ameliorated HFD-induced increase in hepatic TBARS and depletion of SOD, catalase and GSH. TQ prevented reduction in hepatic mRNA of PPAR-α and PPAR-γ in HFD rats, and the effects were comparable to those of pioglitazone.CONCLUSIONS: This study demonstrates protective effect of TQ against HFD-induced MetS on rats which might have been mediated via PPAR mechanism. https://greenmedinfo.com/article/study-demonstrates-protective-effect-thymoquinone-against-hfd-induced-mets-rat#comments High Cholesterol High Fructose Diet Hyperglycemia Insulin Resistance Metabolic Diseases Oxidative Stress Thymoquinone Triglycerides: Elevated Antihypertensive Agents Antioxidants Hypoglycemic Agents Hypolipidemic Pioglitazone (trade Name Actos) Natural Substances Versus Drugs Superiority of Natural Substances versus Drugs Animal Study Thu, 24 Sep 2015 01:15:08 +0000 greenmedinfo 120612 at https://greenmedinfo.com