Alpha Linolenic Acid https://greenmedinfo.com/category/substance/Alpha%20Linolenic%20Acid en Additive anti-inflammation by a combination of conjugated linoleic acid and α-lipoic acid. https://greenmedinfo.com/article/additive-anti-inflammation-combination-conjugated-linoleic-acid-and-lipoic-aci PMID:  Food Sci Biotechnol. 2020 Mar ;29(3):419-429. Epub 2019 Oct 15. PMID: 32257526 Abstract Title:  Additive anti-inflammation by a combination of conjugated linoleic acid andα-lipoic acid through molecular interaction between both compounds. Abstract:  Alpha lipoic acid (LA) and conjugated linoleic acid (CLA) have been well-documented on a variety of functional effects in health foods. The main purpose of this study was focused on the additive anti-inflammatory activity of the combination of LA and CLA in vitro. Raw 264.7 cells induced by lipopolysaccharide were treated with LA and CLA individually or in combination at a variety of concentration ranges. Co-treating 25 μM of LA and 25 μM of CLA significantly inhibited pro-inflammatory cytokines compared to the same concentration of single LA- or CLA-treated group. The molecular mechanism of anti-inflammation by a combination of these compounds was attributed to extracellular signal-regulated kinase-1 (ERK1) and peroxisome proliferator-activated receptor gamma (PPARγ). Also, the molecular interaction between both compounds was confirmed by NMR. Our findings suggested that the combination of CLA and LA showed potential additive effect on anti-inflammation through the molecular interaction of both compounds. <p><a href="https://greenmedinfo.com/article/additive-anti-inflammation-combination-conjugated-linoleic-acid-and-lipoic-aci" target="_blank">read more</a></p> https://greenmedinfo.com/article/additive-anti-inflammation-combination-conjugated-linoleic-acid-and-lipoic-aci#comments Alpha Linolenic Acid Inflammation Linoleic acid Anti-Inflammatory Agents Natural Substance Synergy In Vitro Study Fri, 07 Aug 2020 22:01:11 +0000 greenmedinfo 224855 at https://greenmedinfo.com Alpha linolenic fatty acid supplementation had a beneficial effect on tumor cell proliferation and cachexia parameters. https://greenmedinfo.com/article/alpha-linolenic-fatty-acid-supplementation-had-beneficial-effect-tumor-cell-pr PMID:  Nutr Cancer. 2015 May 26:1-8. Epub 2015 May 26. PMID: 26011096 Abstract Title:  α-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats. Abstract:  Fish oil (FO) has been shown to affect cancer cachexia, tumor mass, and immunity cell. n-3 PUFA, specificallyα-linolenic fatty acid (ALA), has controversial effects. We investigated this in nontumor-bearing Wistar rats fed regular chow (C), fed regular chow and supplemented with FO or Oro Inca oil (OI), and Walker 256 tumor-bearing rats fed regular chow (W), fed regular chow and supplemented with FO (WFO)or OI (WOI). Rats were supplemented (1g/kg body weight/day) during 4 wk and then the groups tumor-bearing were inoculated with Walker 256 tumor cells suspension and 14 days later the animals were killed. WFO increased EPA fivefold and DHA 1.5-fold in the tumor tissue compared to W (P https://greenmedinfo.com/article/alpha-linolenic-fatty-acid-supplementation-had-beneficial-effect-tumor-cell-pr#comments Alpha Linolenic Acid Breast Cancer Cachexia Antiproliferative Cyclooxygenase 2 Inhibitors Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Tue, 23 Jun 2015 23:15:40 +0000 greenmedinfo 118403 at https://greenmedinfo.com Alpha-linolenic acid given as an anti-inflammatory agent in a mouse model of colonic inflammation. https://greenmedinfo.com/article/alpha-linolenic-acid-given-anti-inflammatory-agent-mouse-model-colonic-inflamm PMID:  Food Sci Nutr. 2019 Dec ;7(12):3873-3882. Epub 2019 Nov 19. PMID: 31890165 Abstract Title:  Alpha-linolenic acid given as an anti-inflammatory agent in a mouse model of colonic inflammation. Abstract:  This study examined the relationship between the high-fat, high-sugar diet (HFHSD) and trinitrobenzene sulfonic acid (TNBS) induced mouse colitis, the therapeutic effect of alpha-linolenic acid (ALA) on mouse colitis, and the relationship between HFHSD and hyperlipidemia. We also examined the possible underlying mechanisms behind their interactions. Female BABL/c mice were fed with HFHSD for the 9 weeks. At the same time, ALA treatment (150 or 300 mg/kg) was administered on a daily basis. At the end of the 9 weeks, experimental colitis was induced by the intra-colonic administration of TNBS. Body weight, spleen weight, disease activity index (DAI), histological changes, T-cell-related cytokine level, and lipid profiles were measured after treatment. TNBS induced severe clinical manifestations of colitis and histological damage. Low-ALA (150 mg/kg) administration profoundly ameliorated TNBS-induced clinical manifestations, body weight loss, spleen weight loss, and histological damage. On the contrary, the high-ALA (300 mg/kg) administration did not ameliorate colitis and even exacerbated the symptoms. HFHSD consumption assisted TNBS in changing IL-12, IFN-γ, IL-2, and IL-17A in the liver. As expected, these changes were recovered through low-ALA. In addition, HFHSD had a significant impact on the total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG), which related to the increased risk of hyperlipidemia. In summation, HFHSD exacerbated the TNBS-induced colitis via the Th1/Th17 pathway. The Low-ALA (150 mg/kg) exhibited protectiveeffects against the TNBS-induced colitis via the Th1/Th2/Th17 pathway. <p><a href="https://greenmedinfo.com/article/alpha-linolenic-acid-given-anti-inflammatory-agent-mouse-model-colonic-inflamm" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-linolenic-acid-given-anti-inflammatory-agent-mouse-model-colonic-inflamm#comments Alpha Linolenic Acid Colitis Anti-Inflammatory Agents Anticholesteremic Agents Hypolipidemic Immunomodulatory Animal Study Fri, 07 Feb 2020 00:19:43 +0000 greenmedinfo 210750 at https://greenmedinfo.com Alpha-linolenic acid helped in controlling glycaemia in rats induced to T2DM. https://greenmedinfo.com/article/alpha-linolenic-acid-helped-controlling-glycaemia-rats-induced-t2dm PMID:  J Bioenerg Biomembr. 2020 Nov 6. Epub 2020 Nov 6. PMID: 33156468 Abstract Title:  Effect of alpha linolenic acid on membrane fluidity and respiration of liver mitochondria in normoglycemic and diabetic Wistar rats. Abstract:  The omega 3 fatty acids (ω3FA) have been recommended for the treatment of Type 2 Diabetes Mellitus (T2DM) and its complications, but there are studies questioning those beneficial effects. In this research, we supplemented the short-chain ω3FA, alpha-linolenic acid (ALA), to a model of rats with T2DM and normoglycemic controls, for 5 months. We were mainly interested in studying the effects of diabetes and ALA on the physicochemical properties of mitochondrial membranes and the consequences on mitochondrial respiration. We found that the Respiratory Control (RC) of diabetic rats was 46% lower than in control rats;in diabetic rats with ALA supplement, it was only 23.9% lower, but in control rats with ALA supplement, the RC was 29.5% higher, apparently improving. Diabetes also decreased the membrane fluidity, changed the thermotropic characteristics of membranes, and increased the proportion of saturated fattyacids. ALA supplement partially kept regulated the physicochemical properties of mitochondrial membranes in induced rats. Our data indicate that diabetes decreased the membrane fluidity through changes in the fatty acids composition that simultaneously affected the RC, which means that the mitochondrial respiration is highly dependent on the physicochemical properties of the membranes. Simultaneously, it was followed the effects of ALA on the progress of diabetes and we found also that the supplementation of ALA helped in controlling glycaemia in rats induced to T2DM; however, in control non-induced rats, the supplementation of ALA derived in characteristics of initial development of diabetes. <p><a href="https://greenmedinfo.com/article/alpha-linolenic-acid-helped-controlling-glycaemia-rats-induced-t2dm" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-linolenic-acid-helped-controlling-glycaemia-rats-induced-t2dm#comments Alpha Linolenic Acid Diabetes Mellitus: Type 2 Liver Damage Mitochondrial Dysfunction Risk Factors Animal Study Tue, 01 Dec 2020 20:24:30 +0000 greenmedinfo 230459 at https://greenmedinfo.com Alpha-linolenic acid protects against lipopolysaccharide-induced acute lung injury through anti-inflammatory and anti-oxidative pathways. https://greenmedinfo.com/article/alpha-linolenic-acid-protects-against-lipopolysaccharide-induced-acute-lung-in PMID:  Microb Pathog. 2020 Feb 18 ;142:104077. Epub 2020 Feb 18. PMID: 32084579 Abstract Title:  Alpha-linolenic acid protects against lipopolysaccharide-induced acute lung injury through anti-inflammatory and anti-oxidative pathways. Abstract:  Alpha-linolenic acid (ALA), an important component of polyunsaturated fatty acids (PUFAs), possesses potent anti-inflammatory properties. To date, the effects of ALA on acute lung injury (ALI) remains unknown. This study was designed to investigate the potential protective effects of ALA on LPS-induced ALI and the underpinning mechanisms. An animal model of ALI was established via intratracheally injection of lipopolysaccharide (LPS, 1 mg/kg). We found that lung wet/dry weight ratio and protein concentration in Bronchoalveolar lavage fluid (BALF) were dramatically decreased by ALA pretreatment. Treatment with ALA significantly alleviated the infiltration of total cells and neutrophils, while increased the number of the macrophages. ALA significantly inhibited the secretion of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) and increased anti-inflammatory cytokine. Moreover, we found that the levels of myeloperoxidase (MPO) and malondialdehyde (MDA) were highly increased in LPS-induced ALI, while the activities of glutathione (GSH) and superoxide dismutase (SOD) were decreased, which were reversed by ALA. ALA attenuated LPS-induced histopathological changes and apoptosis. Furthermore, ALA significantly inhibited the phosphorylation of IκBα andNF-κB (p65) activation in ALI. ALA showed anti-inflammatory effects in mice with LPS-induced ALI. NF-κB pathway may be involved in ALA mediated protective effects. <p><a href="https://greenmedinfo.com/article/alpha-linolenic-acid-protects-against-lipopolysaccharide-induced-acute-lung-in" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-linolenic-acid-protects-against-lipopolysaccharide-induced-acute-lung-in#comments Alpha Linolenic Acid Lipopolysaccharide-Induced Toxicity Lung Injury: Acute Anti-Inflammatory Agents Antioxidants Interleukin-1 beta downregulation Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor Animal Study Fri, 06 Mar 2020 19:32:47 +0000 greenmedinfo 215484 at https://greenmedinfo.com Alpha-linolenic acid regulates the gut microbiota and the inflammatory environment in a model of endometriosis. https://greenmedinfo.com/article/alpha-linolenic-acid-regulates-gut-microbiota-and-inflammatory-environment-mod PMID:  Am J Reprod Immunol. 2021 May 22:e13471. Epub 2021 May 22. PMID: 34022075 Abstract Title:  Alpha-linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis. Abstract:  PROBLEM: This study aims to investigate the effects of alpha-linolenic acid (ALA) on the gut microbiota (GM) and the abdominal environment in mice with endometriosis (EMS).METHODS: The effects of faecal microbiota transplantation (FMT) from EMS mice on mice treated with antibiotic cocktail were conducted. The 16S rRNA sequencing and PICRUSt software were used to detect the structure and function of GM respectively. The protein levels of Claudin 4 and ZO-2 in the intestinal wall were detected using the western blotting. The level of LPS in the abdominal cavity was detected using enzyme-linked immunosorbent assay (ELISA). The content of macrophages in the abdominal cavity was detected using flow cytometry.RESULTS: The exogenous supplementation of ALA could restore the abundance of Firmicutes and Bacteroidota in EMS mice. After the ALA treatment, the abundance of 125 functional pathways and 50 abnormal enzymes related to GM in EMS mice was significantly improved (p <p><a href="https://greenmedinfo.com/article/alpha-linolenic-acid-regulates-gut-microbiota-and-inflammatory-environment-mod" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-linolenic-acid-regulates-gut-microbiota-and-inflammatory-environment-mod#comments Alpha Linolenic Acid Endometriosis Gastrointestinal Agents Gastroprotective Animal Study Wed, 16 Jun 2021 19:53:41 +0000 greenmedinfo 241314 at https://greenmedinfo.com Alpha-linolenic acidbut supplementation improves endothelial dysfunction and diminishes experimental hypertension. https://greenmedinfo.com/article/alpha-linolenic-acidbut-supplementation-improves-endothelial-dysfunction-and-d PMID:  Cell Death Dis. 2020 Feb 3 ;11(2):83. Epub 2020 Feb 3. PMID: 32015327 Abstract Title:  α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux. Abstract:  Although dietaryα-linolenic acid (ALA) or linolenic acid (LA) intake was reported to be epidemiologically associated with a lower prevalence of hypertension, recent clinical trials have yielded conflicting results. Comparable experimental evidence for the roles of these two different fatty acids is still lacking and the underlying mechanisms need to be further elucidated. Our data showed that ALA but not LA supplementation alleviated systolic blood pressure elevation and improved ACh-induced, endothelium-dependent vasodilation in both spontaneously hypertensive rats (SHRs) and AngII-induced hypertensive mice. In addition, SHRs displayed reduced vascular Sirtuin 3 (SIRT3) expression, subsequent superoxide dismutase 2 (SOD2) hyperacetylation and mitochondrial ROS overproduction, all of which were ameliorated by ALA but not LA supplementation. In primary cultured endothelial cells, ALA treatment directlyinhibited SIRT3 reduction, SOD2 hyperacetylation, mitochondrial ROS overproduction and alleviated autophagic flux impairment induced by AngII plus TNFα treatment. However, these beneficial effects of ALA were completely blocked by silencing SIRT3. Restoration of autophagic flux by rapamycin also inhibited mitochondrial ROS overproduction in endothelial cells exposed to AngII plus TNFα. More interestingly, SIRT3 KO mice developed severe hypertension in response to a low dose of AngII infusion, while ALA supplementation lost its anti-hypertensive and endothelium-protective effects on these mice. Our findings suggest that ALA but not LA supplementation improves endothelial dysfunction and diminishes experimental hypertension by rescuing SIRT3 impairment to restore autophagic flux and mitochondrial redox balance in endothelial cells. <p><a href="https://greenmedinfo.com/article/alpha-linolenic-acidbut-supplementation-improves-endothelial-dysfunction-and-d" target="_blank">read more</a></p> https://greenmedinfo.com/article/alpha-linolenic-acidbut-supplementation-improves-endothelial-dysfunction-and-d#comments Alpha Linolenic Acid Endothelial Dysfunction Hypertension Antihypertensive Agents Antioxidants Animal Study Fri, 07 Feb 2020 00:15:17 +0000 greenmedinfo 210749 at https://greenmedinfo.com Consumption of alpha-lipoic acid-rich foods may prevent the development of H. pylori-associated gastric diseases. https://greenmedinfo.com/article/consumption-alpha-lipoic-acid-rich-foods-may-prevent-development-h-pylori-asso PMID:  Nutrients. 2019 Oct 19 ;11(10). Epub 2019 Oct 19. PMID: 31635029 Abstract Title:  α-Lipoic Acid Inhibits IL-8 Expression by Activating Nrf2 Signaling in-infected Gastric Epithelial Cells. Abstract:  causes gastritis and gastric cancers. Oxidative stress is involved in the pathological mechanism of-induced gastritis and gastric cancer induction. Therefore, reducing oxidative stress may be beneficial for preventing the development of-associated gastric diseases. Nuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial regulator for the expression of antioxidant enzyme heme oxygenase-1 (HO-1), which protects cells from oxidative injury.α-Lipoic acid (α-LA), a naturally occurring dithiol, shows antioxidant and anti-inflammatory effects in various cells. In the present study, we examined the mechanism by which α-LA activates the Nrf2/HO-1 pathway, suppresses the production of pro-inflammatory cytokine interleukine-8 (IL-8), and reduces reactive oxygen species (ROS) in-infected AGS cells.α-LA increased the level of phosphorylated and nuclear-translocated Nrf2 by decreasing the amount of Nrf2 sequestered in the cytoplasm by complex formation with Kelch-like ECH1-associated protein 1 (KEAP 1). By using exogenous inhibitors targeting Nrf2 and HO-1, we showed that up-regulation of activated Nrf2 and of HO-1 results in the α-LA-induced suppression of interleukin 8 (IL-8) and ROS. Consumption of α-LA-rich foods may prevent the development of-associated gastric diseases by decreasing ROS-mediated IL-8 expression in gastric epithelial cells. <p><a href="https://greenmedinfo.com/article/consumption-alpha-lipoic-acid-rich-foods-may-prevent-development-h-pylori-asso" target="_blank">read more</a></p> https://greenmedinfo.com/article/consumption-alpha-lipoic-acid-rich-foods-may-prevent-development-h-pylori-asso#comments Alpha Linolenic Acid Helicobacter Pylori Infection Antioxidants Heme oxygenase-1 up-regulation Interleukin-8 downregulation Nrf2 activation In Vitro Study Sat, 26 Oct 2019 17:37:03 +0000 greenmedinfo 200135 at https://greenmedinfo.com Correlations between α-linolenic acid-improved multitissue homeostasis and gut microbiota in mice fed a high-fat diet. https://greenmedinfo.com/article/correlations-between-linolenic-acid-improved-multitissue-homeostasis-and-gut-m PMID:  mSystems. 2020 Nov 3 ;5(6). Epub 2020 Nov 3. PMID: 33144308 Abstract Title:  Correlations betweenα-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet. Abstract:  Previous studies have shown thatα-linolenic acid (ALA) has a significant regulatory effect on related disorders induced by high-fat diets (HFDs), but little is known regarding the correlation between the gut microbiota and disease-related multitissue homeostasis. We systematically investigated the effects of ALA on the body composition, glucose homeostasis, hyperlipidemia, metabolic endotoxemia and systemic inflammation, white adipose tissue (WAT) homeostasis, liver homeostasis, intestinal homeostasis, and gut microbiota of mice fed an HFD (HFD mice). We found that ALA improved HFD-induced multitissue metabolic disorders and gut microbiota disorders to various degrees. Importantly, we established a complex but clear network between the gut microbiota and host parameters. Several specific differential bacteria were significantly associated with improved host parameters._RC9_gut_group andwere positively correlated with HFD-induced&quot;harmful indicators&quot;and negatively correlated with&quot;beneficial indicators.&quot;Intriguingly,showed a strong negative correlation with HFD-induced multitissue metabolic disorders and a significant positive correlation with most beneficial indicators, which is different from its previous characterization as a&quot;potentially harmful genus.&quot;might be the key beneficial bacterium for ALA-improved metabolic endotoxemia, whilemight play an important role in ALA-improved gut barrier integrity and anti-inflammatory effects. The results suggested that the gut microbiota, especially some specific bacteria, played an important role in the process of ALA-improved multitissue homeostasis in HFD mice, and different bacteria might have different divisions of regulation.Insufficient intake of-3 polyunsaturated fatty acids is an important issue in modern Western-style diets. A large amount of evidence now suggests that a balanced intestinal microecology is considered an important part of health. Our results show thatα-linolenic acid administration significantly improved the host metabolic phenotype and gut microbiota of mice fed a high-fat diet, and there was a correlation between the improved gut microbiota and metabolic phenotype. Some specific bacteria may play a unique regulatory role. Here, we have established correlation networks between gut microbiota and multitissue homeostasis, which may provide a new basis for further elucidating the relationship between the gut microbiota and host metabolism. <p><a href="https://greenmedinfo.com/article/correlations-between-linolenic-acid-improved-multitissue-homeostasis-and-gut-m" target="_blank">read more</a></p> https://greenmedinfo.com/article/correlations-between-linolenic-acid-improved-multitissue-homeostasis-and-gut-m#comments Alpha Linolenic Acid High Fat Diet Gastrointestinal Agents Animal Study Tue, 01 Dec 2020 19:36:30 +0000 greenmedinfo 230451 at https://greenmedinfo.com Dietary and plasma blood α-linolenic acid as modulators of fat oxidation and predictors of aerobic performance. https://greenmedinfo.com/article/dietary-and-plasma-blood-linolenic-acid-modulators-fat-oxidation-and-predictor PMID:  J Int Soc Sports Nutr. 2020 Nov 16 ;17(1):57. Epub 2020 Nov 16. PMID: 33198755 Abstract Title:  Dietary and plasma bloodα-linolenic acid as modulators of fat oxidation and predictors of aerobic performance. Abstract:  BACKGROUND: Among n-3 polyunsaturated fatty acids (PUFAs), the most important isα-linolenic acid (ALA). The biological activity of ALA is not equivalent to that of the long-chain n-3 PUFAs, and it has pleiotropic effects, such as functioning as an energy substrate during long-term training when carbohydrate reserves are depleted. The purpose of this investigation was to studythe link between the essential dietary and plasma ALA and aerobic performance, which is estimated via maximal fat oxidation (MFO), among skiers.METHODS: Twenty-four highly trained male athletes from the Russian cross-country skiing team participated in the study. ALA intake was determined by an original program used to assess the actual amount and frequency of fat consumption. The plasma level of ALA was determined using gas-liquid chromatography. The skiers&#039; aerobic performance was estimated via MFO and determined by indirect calorimetry using the system&quot;Oxycon Pro&quot;.RESULTS: The consumption of ALA in the diet in half of the skiers was below the recommended level at 0.5 ± 0.2 g/day. The deficiency of plasma ALA levels was on average 0.2 ± 0.1 Mol% for almost all participants. The consumption of ALA in the diet and its level in plasma were associated with MFO (r = 0.507, p = 0.011; r = 0.460, p = 0.023). Levels of ALA in plasma (p = 0.0523) and the consumption of ALA in the diet (p = 0.0039) were associated with high aerobic performance.CONCLUSIONS: ALA in the diet of the athletes may be used as nutritional support to increase MFO and aerobic performance. <p><a href="https://greenmedinfo.com/article/dietary-and-plasma-blood-linolenic-acid-modulators-fat-oxidation-and-predictor" target="_blank">read more</a></p> https://greenmedinfo.com/article/dietary-and-plasma-blood-linolenic-acid-modulators-fat-oxidation-and-predictor#comments Alpha Linolenic Acid Athletic Performance Exercise Human Study Tue, 01 Dec 2020 20:05:23 +0000 greenmedinfo 230454 at https://greenmedinfo.com Effect of alpha-linolenic acid in combination with the flavonol quercetin on markers of cardiovascular disease risk. https://greenmedinfo.com/article/effect-alpha-linolenic-acid-combination-flavonol-quercetin-markers-cardiovascu PMID:  Nutrition. 2019 Feb ;58:47-56. Epub 2018 Jul 12. PMID: 30278429 Abstract Title:  Effect of alpha-linolenic acid in combination with the flavonol quercetin on markers of cardiovascular disease risk in healthy, non-obese adults: A randomized, double-blinded placebo-controlled crossover trial. Abstract:  OBJECTIVES: Alpha-linolenic acid (ALA) and quercetin are characteristic compounds in plant-based diets. Cardioprotective effects have been described for both substances, although a possible benefit of combining ALA and quercetin has not, to our knowledge, been evaluated yet. The aim of this study was to investigate the potential independent and additive effects of ALA and quercetin on blood pressure (BP) and lipid and glucose metabolism, as well as on biomarkers of inflammation, oxidative stress, and antioxidant status in healthy, non-obese men and women. Another aim was to examine whether chronic supplementation of supranutritional doses of quercetin would result in an accumulation of plasma quercetin concentration over time.METHODS: In a double-blinded, placebo-controlled crossover trial, healthy volunteers were randomized to receive 3.6 g/d ALA plus 190 mg/d quercetin or placebo for 8 wk. Data from 67 individuals (34 men, 33 women, mean age: 24.6 y) were assessed.RESULTS: Plasma quercetin, tamarixetin, isorhamnetin, and kaempferol increased significantly from baseline to study end with ALA + quercetin but not with ALA + placebo. No significant effect on office systolic BP, mean 24 h ambulatory BP (ABP), or mean daytime ABP was seen in either study group. Both interventions significantly decreased total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B to a similar extent. No effect on high-density lipoprotein cholesterol, apolipoprotein A1, glucose, uric acid, oxidized low-density lipoprotein, C-reactive protein, or lipid-adjusted retinol,α-tocopherol, orβ-carotene was seen in either group.CONCLUSION: Although dietary supplements of 3.6 g/d ALA over an 8-wk period improved lipid profiles in healthy adults, antioxidative and oxidative status, inflammation, and BP remained unchanged. No evidence was seen for an additive or synergistic effect of ALA plus quercetin on markers of cardiovascular disease risk. <p><a href="https://greenmedinfo.com/article/effect-alpha-linolenic-acid-combination-flavonol-quercetin-markers-cardiovascu" target="_blank">read more</a></p> https://greenmedinfo.com/article/effect-alpha-linolenic-acid-combination-flavonol-quercetin-markers-cardiovascu#comments Alpha Linolenic Acid Cardiovascular Diseases Obesity Quercetin Anticholesteremic Agents Cardioprotective Human Study Sat, 10 Feb 2024 20:26:47 +0000 greenmedinfo 288158 at https://greenmedinfo.com Effects of nano-α-linolenic acid and miR-146 on mice with viral myocarditis. https://greenmedinfo.com/article/effects-nano-linolenic-acid-and-mir-146-mice-viral-myocarditis PMID:  J Nanosci Nanotechnol. 2021 Feb 1 ;21(2):1365-1371. PMID: 33183485 Abstract Title:  Effects of Nano-α-Linolenic Acid and miR-146 on Mice with Viral Myocarditis. Abstract:  Micro RNA-146 (miR-146) is involved in mediating many innate and adaptive immune and inflammatory responses in the body. It is associated with a variety of systemic inflammation or autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and type 2 diabetes. In recent years, microRNAs (miRNAs) and nanotechnology have become research hotspots in cardiovascular pathology. The close relationship between host miRNAs andhas gradually been discovered by scientists, which may provide new directions for the treatment and prevention of viral myocarditis. At the same time, recent studies have also found that nano--linolenic acid and its metabolites can inhibit the production of inflammatory cytokines such as TNF-and IL-17; At the same time, they also have anti-lipid peroxidation effects. Therefore, in order to further explore the role of miR-146 and nano--linolenic acid in the occurrence and development of viral myocarditis, in this study, a mouse model of viral myocarditis was used to establish a VMC mouse model using. Intervention with different doses of nano--linolenic acid, the control group was injected with the same amount of sodium chloride buffer, and the changes in cardiac function and inflammation indexes were compared to evaluate the role in the pathogenesis of viral myocarditis. The results showed that this study suggested that serum miR-146 concentration in viral myocarditis mice is increased and is positively correlated with serum IL-17 and TNF-concentrations. This suggest that miR-146 in the circulation may be involved in the pathogenesis of viral myocarditis through IL-17 and TNF-, providing a theoretical basis for the role of miR-146 in viral myocarditis, but its specific mechanism of action needs to be further studied. At the same time, the research in this experiment showed that nano--linolenic acid significantly improves the survival rate of CVB3 infected mice and reduces myocardial damage. And with the increase of the dosage of nano--linolenic acid, the effect is more significant, showing a significant dose-effect relationship. <p><a href="https://greenmedinfo.com/article/effects-nano-linolenic-acid-and-mir-146-mice-viral-myocarditis" target="_blank">read more</a></p> https://greenmedinfo.com/article/effects-nano-linolenic-acid-and-mir-146-mice-viral-myocarditis#comments Alpha Linolenic Acid Myocarditis: Viral Cardioprotective MicroRNA modulator Animal Study Tue, 01 Dec 2020 20:13:41 +0000 greenmedinfo 230457 at https://greenmedinfo.com Egg consumption in U.S. children is associated with greater daily nutrient intakes. https://greenmedinfo.com/article/egg-consumption-us-children-associated-greater-daily-nutrient-intakes PMID:  Nutrients. 2019 May 22 ;11(5). Epub 2019 May 22. PMID: 31121847 Abstract Title:  Egg Consumption in U.S. Children is Associated with Greater Daily Nutrient Intakes, including Protein, Lutein + Zeaxanthin, Choline,α-Linolenic Acid, and Docosahexanoic Acid. Abstract:  Dietary pattern recommendations include consuming a variety of nutrient-dense foods in children and adolescents to promote optimal growth and development. The current study investigated associations with egg consumption and nutrient intakes, diet quality, and growth outcomes relative to non-egg consumers. The analysis used data from the U.S. National Health and Nutrition Examination Survey (NHANES) 2001-2012 in children and adolescents aged 2-18 years (= 3,299, egg consumers;= 17,030, egg non-consumers). Daily energy and nutrient intakes were adjusted for the complex sample design of NHANES using appropriate weights. Consuming eggs was associated with increased daily energy intake relative to non-egg consumption. Children and adolescents consuming eggs had elevated daily intake of protein, polyunsaturated, monounsaturated and total fat,α-linolenic acid, docosahexaenoic acid (DHA), choline, lutein + zeaxanthin, vitamin D, potassium, phosphorus, and selenium. Egg consumers had greater consumption, sodium, saturated fat, with reduced total and added sugar versus egg non-consumers. The analysis also showed that egg consumption was linked with lower intake of dietary folate, iron, and niacin. No associations were determined when examining diet quality and growth-related measures. A sub-analysis considering socioeconomic status showed that egg consumption was positively related with daily lutein + zeaxanthin and DHA intake. The current analysis demonstrated several nutrient-related benefits to support the continued inclusion of eggs in the dietary patterns of children and adolescents. <p><a href="https://greenmedinfo.com/article/egg-consumption-us-children-associated-greater-daily-nutrient-intakes" target="_blank">read more</a></p> https://greenmedinfo.com/article/egg-consumption-us-children-associated-greater-daily-nutrient-intakes#comments Alpha Linolenic Acid Choline DHA (Docosahexaenoic Acid) Egg Zeaxanthin Human Study Fri, 31 May 2019 01:20:02 +0000 greenmedinfo 188501 at https://greenmedinfo.com Natural compounds against doxorubicin-induced cardiotoxicity. https://greenmedinfo.com/article/natural-compounds-against-doxorubicin-induced-cardiotoxicity PMID:  Phytother Res. 2020 Sep 28. Epub 2020 Sep 28. PMID: 32985744 Abstract Title:  Natural compounds against doxorubicin-induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway. Abstract:  Cardiotoxicity is the main concern for long-term use of the doxorubicin (DOX). Reactive oxygen species (ROS) generation leads to oxidative stress that significantly contributes to the cardiac damage induced by DOX. The nuclear factor erythroid 2-related factor (Nrf2) acts as a protective player against DOX-induced myocardial oxidative stress. Several natural compounds (NCs) with anti-oxidative effects, were examined to suppress DOX cardiotoxicity such as asiatic acid,α-linolenic acid, apigenin, baicalein, β-lapachone, curdione, dioscin, ferulic acid, Ganoderma lucidum polysaccharides, genistein, ginsenoside Rg3, indole-3-carbinol, naringenin-7-O-glucoside, neferine, p-coumaric acid, pristimerin, punicalagin, quercetin, sulforaphane, and tanshinone IIA. The present article, reviews NCs that showed protective effects against DOX-induced cardiac injury through induction of Nrf2 signaling pathway. <p><a href="https://greenmedinfo.com/article/natural-compounds-against-doxorubicin-induced-cardiotoxicity" target="_blank">read more</a></p> https://greenmedinfo.com/article/natural-compounds-against-doxorubicin-induced-cardiotoxicity#comments Alpha Linolenic Acid Apigenin Asiatic Acid Chemotherapy-Induced Toxicity: Doxorubicin Ferulic acid Genistein Ginsenosides Indole-3-Carbinol Naringenin P-Coumaric Acid Punicalagin Quercetin Reishi Mushroom Sulforaphane Tanshinone IIA Antioxidants Cardioprotective Chemoprotective Agents Nrf2 activation Polysaccharides In Vitro Study Fri, 16 Oct 2020 18:17:12 +0000 greenmedinfo 228225 at https://greenmedinfo.com Natural products may interfere With SARS-CoV-2 attachment to the host cell. https://greenmedinfo.com/article/natural-products-may-interfere-sars-cov-2-attachment-host-cell n/a PMID:  J Biomol Struct Dyn. 2020 May 5:1-10. Epub 2020 May 5. PMID: 32340551 Abstract Title:  Natural products may interfere with SARS-CoV-2 attachment to the host cell. Abstract:  SARS-CoV-2 has been emerged in December 2019 in China, causing deadly (5% mortality) pandemic pneumonia, termed COVID-19. More than one host-cell receptor is reported to be recognized by the viral spike protein, among them is the cell-surface Heat Shock Protein A5 (HSPA5), also termed GRP78 or BiP. Upon viral infection, HSPA5 is upregulated, then translocating to the cell membrane where it is subjected to be recognized by the SARS-CoV-2 spike. In this study, some natural product compounds are tested against the HSPA5 substrate-binding domainβ (SBDβ), which reported to be the recognition site for the SARS-CoV-2 spike. Molecular docking and molecular dynamics simulations are used to test some natural compounds binding to HSPA5 SBDβ. The results show high to a moderate binding affinity for the phytoestrogens (Diadiazin, Genistein, Formontein, and Biochanin A), chlorogenic acid, linolenic acid, palmitic acid, caffeic acid, caffeic acid phenethyl ester, hydroxytyrosol, cis-p-Coumaric acid, cinnamaldehyde, thymoquinone, and some physiological hormones such as estrogens, progesterone, testosterone, and cholesterol to the HSPA5 SBDβ.Based on its binding affinities, the phytoestrogens and estrogens are the best in binding HSPA5, hence may interfere with SARS-CoV-2 attachment to the stressed cells. These compounds can be successful as anti-COVID-19 agents for people with a high risk of cell stress like elders, cancer patients, and front-line medical staff.Communicated by Ramaswamy H. Sarma. https://greenmedinfo.com/article/natural-products-may-interfere-sars-cov-2-attachment-host-cell#comments Alpha Linolenic Acid Biochanin A Caffeic Acid Caffeic acid phenethyl ester Chlorogenic Acid Cinnamaldehyde Coronavirus Infection Formononetin Genistein Hydroxytyrosol Thymoquinone Antiviral Agents In Vitro Study Fri, 05 Jun 2020 15:18:14 +0000 greenmedinfo 221530 at https://greenmedinfo.com