Homocysteine: Elevated https://greenmedinfo.com/category/keywords/Homocysteine%3A%20Elevated en Folic acid supplementation increased high-density lipoprotein-cholesterol, decreased plasma homocysteine levels and improved antioxidant capacity. https://greenmedinfo.com/article/folic-acid-supplementation-increased-high-density-lipoprotein-cholesterol-decr n/a PMID:  Appl Physiol Nutr Metab. 2017 Jun 2. Epub 2017 Jun 2. PMID: 28575637 Abstract Title:  Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats. Abstract:  Atherosclerosis is a chronic disease that can seriously endanger human life. Folic acid supplementation modulates several disorders, including atherosclerosis, via its antiapoptotic and antioxidative properties. This study investigated whether folic acid alleviates atherogenesis by restoring homocysteine levels and antioxidative capacity in atherosclerosis Wistar rats. To this end, 28 Wistar rats were randomly divided into four groups (7 rats/group) as follows: (a) wild-type (WT) group, fed only the AIN-93 semi-purified rodent diet (folic acid: 2.1 mg/kg); (b) high-fat + folic acid-deficient group (HF+DEF) (folic acid: 0.2 mg/kg); (c) high-fat + normal folic acid group (HF+CON) (folic acid: 2.1 mg/kg); and (d) high-fat + folic acid-supplemented group (HF+FA) (folic acid: 4.2 mg/kg). After 12 weeks, histopathological changes in the atherosclerotic lesions of the aortic arch were determined. In addition, serum folate levels, plasma homocysteine levels, plasma s-adenosyl-homocysteine levels, antioxidant status, oxidant status, and lipid profiles were evaluated. The results show aggravated atherosclerotic lesions in the HF+DEF group. Folic acid supplementation increased concentrations of serum folate. Further, folic acid supplementation increased high-density lipoprotein-cholesterol, decreased plasma homocysteine levels and improved antioxidant capacity in atherogenic rats. These findings are consistent with the hypothesis that folic acid alleviates atherogenesis by reducing plasma homocysteine levels and improving antioxidant capacity in rats fed a high-fat diet. https://greenmedinfo.com/article/folic-acid-supplementation-increased-high-density-lipoprotein-cholesterol-decr#comments Atherosclerosis Folic Acid Homocysteine: Elevated Antioxidants Antioxidants Atherosclerosis folic acid Homocysteine: Elevated Animal Study Thu, 06 Jul 2017 00:42:52 +0000 greenmedinfo 150104 at https://greenmedinfo.com Serum homocysteine may play a role in cognitive dysfunction in MS patients. https://greenmedinfo.com/article/serum-homocysteine-may-play-role-cognitive-dysfunction-ms-patients n/a PMID:  Int J Neurosci. 2018 Feb 21:1-7. Epub 2018 Feb 21. PMID: 29384421 Abstract Title:  Relation of serum levels of homocysteine, vitamin B12 and folate to cognitive functions in multiple sclerosis patients. Abstract:  BACKGROUND: Hyperhomocysteinemia, vitamin B12 and folate deficiency have been linked to cognitive dysfunction in multiple sclerosis (MS) patients. OBJECTIVE: This study aimed to investigate the relation of serum homocysteine (Hcy), vitamin B12 and folate to cognitive functions in MS patients. SUBJECTS AND METHODS: Forty-five MS patients and twenty matched healthy controls were included. Subjects were submitted to cognitive assessment using a selected psychometric battery and measurement of serum levels of homocysteine, B12 and folic acid. RESULTS: MS patients showed significant worse performance in cognitive scales compared to controls (P ≤ 0.05). Serum homocysteine, vitamin B12 and folate showed no significant difference between patients and controls (P  >0.05). Serum homocysteine was negatively correlated with total score of Addenbrooke's Cognitive Examination (ACE), paced auditory serial addition test and controlled oral word association test scores. Serum vitamin B12 was positively correlated with ACE language, visuospatial and total scores and negatively correlated with trail making B score. Serum folate was significantly positively correlated with ACE language and total scores. Homocysteine was the only significant predictor for cognitive impairment in MS patients. CONCLUSION: Serum homocysteine may play a role in cognitive dysfunction in MS patients. https://greenmedinfo.com/article/serum-homocysteine-may-play-role-cognitive-dysfunction-ms-patients#comments Cognitive Decline/Dysfunction Homocysteine: Elevated Multiple Sclerosis Cognitive Decline/Dysfunction Homocysteine: Elevated Multiple Sclerosis Risk Factors Human Study Wed, 30 May 2018 22:07:17 +0000 greenmedinfo 165008 at https://greenmedinfo.com