Aggression https://greenmedinfo.com/category/keywords/Aggression en Mice increased target biting behaviors 24h after co-administration of alcohol and fluoxetine. https://greenmedinfo.com/article/mice-increased-target-biting-behaviors-24h-after-co-administration-alcohol-and n/a PMID:  Brain Res. 2017 05 1 ;1662:110-115. Epub 2017 Feb 11. PMID: 28193480 Abstract Title:  Mice increased target biting behaviors 24h after co-administration of alcohol and fluoxetine. Abstract:  Increased alcohol consumption and heightened aggression have been linked to social isolation. Furthermore, animals treated with alcohol following social separation showed higher aggression together with lower serotonin transmission. Although reduced serotonin transmission in the brain may be related to alcohol-induced heightened aggression and fluoxetine has been used to reduce alcohol intake and aggression, it remains unclear whether there are specific brain regions where changes in serotonin transmission are critical for animal aggression following the alcohol treatment. In the present study, we isolated mice for 4-6weeks and injected them with alcohol, fluoxetine and alcohol with fluoxetine. We studied their aggression by using two types of behavioral paradigms: isolation-induced attack behavior towards a naïve mouse in a neutral cage, or shock-induced target biting aggression. We observed that alcohol administered at 500mg/kg significantly increased animal attack behaviors towards naïve mice 30min after injections. This dose of alcohol co-administered with a low dose of fluoxetine (2mg/kg) further increased the attack behaviors, but with higher doses of fluoxetine, the attack behaviors were decreased. Alcohol administered at a dose of 1,000mg/kg significantly decreased the shock-induced target biting rates 24h after injections. Interestingly, 24h after injections, we observed a significant increase in target biting rates when alcohol was co-administered with fluoxetine at a dose of 16mg/kg. We also observed the same heightened target biting rates when animals were injected with fluoxetine alone. This heightened biting attack engendered by the fluoxetine (alone or in combination with thealcohol) occurred at a time when brain serotonin activity was reduced by these drugs in the frontal cortex and hypothalamus. These observations, in concordance with previous findings reported by others, indicate that heightened biting attack behavior may be associated with reduced serotonergic activity in brain regions regulating aggression. https://greenmedinfo.com/article/mice-increased-target-biting-behaviors-24h-after-co-administration-alcohol-and#comments Aggression Alcohol Toxicity Fluoxetine (trade name Prozac) Aggression Alcohol Toxicity Fluoxetine (trade name Prozac) Animal Study Tue, 20 Feb 2018 17:58:07 +0000 greenmedinfo 160155 at https://greenmedinfo.com Most Cheese Products Tainted with Dangerous Plastic Chemicals, Study Reveals https://greenmedinfo.com/blog/most-cheese-products-tainted-dangerous-plastic-chemicals-study-reveals <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2019<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/StudyRevealsCheeseProductsTaintedWithPlasticChemicals.jpg" style="width: 600px; height: 315px;" title="Most Cheese Products Tainted with Dangerous Plastic Chemicals, Study Reveals" /></p> <p><span style="font-size:18px;"><em><strong>A University of Washington study involving cheese products found endocrine-disrupting phthalates present in 29 of 30 samples tested</strong></em></span></p><p><a href="https://greenmedinfo.com/blog/most-cheese-products-tainted-dangerous-plastic-chemicals-study-reveals" target="_blank">read more</a></p> https://greenmedinfo.com/blog/most-cheese-products-tainted-dangerous-plastic-chemicals-study-reveals#comments Aggression Birth Defects Cruciferous Vegetables Endometriosis Fruit: All Insulin Resistance Learning disorders Testicular Cancer Vegetables: All Water Chemical and Drug Toxicity Endocrine Disruptor Exercise Phthalates Western Diet Aggression birth defects Chemicals in Cheese Cruciferous Vegetables Endocrine Disrupting Chemicals (EDCs) Endometriosis exercise Phthalates processed food Tue, 18 Jul 2017 23:09:41 +0000 Biraalo 150608 at https://greenmedinfo.com The results in the current study indicate that developmental SSRI exposure causes long-lasting behavioural effects in fish. https://greenmedinfo.com/article/results-current-study-indicate-developmental-ssri-exposure-causes-long-lasting n/a PMID:  Ecotoxicology. 2018 Jan ;27(1):12-22. Epub 2017 Oct 23. PMID: 29058178 Abstract Title:  Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus). Abstract:  Selective Serotonin re-uptake inhibitors (SSRIs) are a class of psychotropic drugs used to treat depression in both adolescents and pregnant or breast-feeding mothers as well as in the general population. Recent research on rodents points to long-lasting behavioural effects of pre- and perinatal exposure to SSRIs which last into adulthood. In fish however, studies on effects of developmental exposure to SSRIs appears to be non-existent. In order to study effects of developmental SSRI exposure in fish, three-spine sticklebacks were exposed to 1.5 µg/l of the SSRI citalopram in the ambient water for 30 days, starting two days post-fertilisation. After approximately 100 days of remediation in clean water the fish were put through an extensive battery of behavioural tests. Feeding behaviour was tested as the number of bites against a pieceof food and found to be increased in the exposed fish. Aggression levels were measured as the number of bites against a mirror image during 10 min and was also found to be significantly increased in the exposed fish. Novel tank behaviour and locomotor activity was tested in an aquarium that had ahorizontal line drawn half-way between the bottom and the surface. Neither the latency to the first transition to the upper half, nor the number of transitions or the total time spent in the upper half was affected by treatment. Locomotor activity was significantly reduced in the exposed fish. The light/dark preference was tested in an aquarium where the bottom and walls were black on one side and white on the other. The number of transitions to the white side was significantly reduced in the exposed fish but there was no effect on the latency to the first transition or the total time spent inthe white half. The results in the current study indicate that developmental SSRI exposure causes long-lasting behavioural effects in fish and contribute to the existing knowledge about SSRIs as environmental pollutants. https://greenmedinfo.com/article/results-current-study-indicate-developmental-ssri-exposure-causes-long-lasting#comments Aggression Selective Serotonin Reuptake Inhibitors (SSRIs) Aggression Environmental Fate of Pharmacueticals Environmental Pollution Risk Factors Animal Study Tue, 20 Feb 2018 17:47:41 +0000 greenmedinfo 160154 at https://greenmedinfo.com