Nicotine/Tobacco Toxicity https://greenmedinfo.com/category/keywords/Nicotine/Tobacco%20Toxicity en Cleaning Products As Damaging As Smoking 20 Cigarettes A Day https://greenmedinfo.com/blog/cleaning-products-damaging-smoking-20-cigarettes-day1 <div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2023<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><span style="font-size:14px;"><span style="font-family:verdana,geneva,sans-serif;"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Home-CleaningProductsHaveLong-TermEffectsonLungs.jpg" style="width: 600px; height: 315px;" /></span></span></p> <p><span style="font-size:22px;"><span style="font-family:verdana,geneva,sans-serif;"><em><strong>A surprising new study on the long-term health effects of cleaning products found that inhaling sprays and other chemical cleaners at home or work may be as damaging to lungs as a 20-year, pack-a-day smoking habit</strong></em></span></span></p><p><a href="https://greenmedinfo.com/blog/cleaning-products-damaging-smoking-20-cigarettes-day1" target="_blank">read more</a></p> https://greenmedinfo.com/blog/cleaning-products-damaging-smoking-20-cigarettes-day1#comments Airway Obstruction Asthma Chemical Exposure Inflammation Chemical and Drug Toxicity Cleaning Products Health Guide: Chemical Exposures Tobacco: Smoking Women's Health chemical exposure lungs Nicotine/Tobacco Toxicity Wed, 29 Nov 2023 13:03:53 +0000 GMI Research Group 160454 at https://greenmedinfo.com Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin. https://greenmedinfo.com/article/increase-motility-and-invasiveness-mcf7-cancer-cells-induced-nicotine-abolishe n/a PMID:  J Pineal Res. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29338098 Abstract Title:  Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. Abstract:  Through activation of the ERK pathway nicotine, in both normal MCF-10A and low malignant breast cancer cells (MCF7), promotes increased motility and invasiveness. Melatonin antagonizes both these effects by inhibiting almost completely ERK phosphorylation. As melatonin has no effect on not-stimulated cells, it is likely that melatonin can counteract ERK-activation only downstream of nicotine-induced activation. This finding suggests that melatonin hampers ERK phosphorylation presumably by targeting a still unknown intermediate factor that connects nicotine stimulation to ERK phosphorylation. Furthermore, downstream of ERK activation, melatonin significantly reduces Fascin and Calpain activation while restoring normal Vinculin levels. Melatonin also counteracts nicotine effects by reshaping the overall cytoskeleton architecture and abolishing invasive membrane protrusion. In addition, melatonin decreases nicotine-dependent ROCK1/ROCK2 activation, thus further inhibiting cell contractility and motility. Melatonin actions are most likely attributable to ERK inhibition, although melatonin could display other ERK-independent effects, namely through a direct modulation of additional molecular and structural factors, including Coronin, Cofilin and cytoskeleton components. This article is protected by copyright. All rights reserved. https://greenmedinfo.com/article/increase-motility-and-invasiveness-mcf7-cancer-cells-induced-nicotine-abolishe#comments Breast Cancer Melatonin Nicotine/Tobacco Toxicity Anti-metastatic Anti-metastatic Breast Cancer melatonin Nicotine/Tobacco Toxicity In Vitro Study Fri, 19 Jan 2018 17:03:26 +0000 greenmedinfo 158590 at https://greenmedinfo.com