Lupine https://greenmedinfo.com/category/substance/Lupine en Adverse Reaction: Anticholinergic toxicity after ingesting lupine seeds demonstrates the danger of unproven home remedies. https://greenmedinfo.com/article/adverse-reaction-anticholinergic-toxicity-after-ingesting-lupine-seeds-demonst PMID:  Ann Emerg Med. 1999 Jun ;33(6):715-7. PMID: 10339689 Abstract Title:  Anticholinergic toxicity associated with ingestion of lupine seeds as a home remedy for diabetes mellitus. Abstract:  We describe a case of sparteine intoxication associated with using a preparation from lupine seeds. A female patient of Portuguese origin presented to the emergency department with classic anticholinergic signs after ingestion of a lupine seed extract. She took the preparation with the belief it represented a cure for her recently diagnosed diabetes. Analysis of the patient&#039;s lupine bean extract identified the preponderant compound as oxo-sparteine by gas chromatography/mass spectrometry. Intoxication by lupine seeds rarely occurs in human beings. To our knowledge, no medical or toxicologic evidence supports a belief that lupine extract could lower serum glucose levels. This case highlights the need for emergency care providers to be aware of the health hazards that can be associated with the use of such home remedies. https://greenmedinfo.com/article/adverse-reaction-anticholinergic-toxicity-after-ingesting-lupine-seeds-demonst#comments Lupine Adverse Reaction Anticholinergic Toxicity Diabetes Mellitus Lupine Human: Case Report Sun, 01 Apr 2012 15:32:55 +0000 greenmedinfo 73813 at https://greenmedinfo.com Efficacy of a Lupinus mutabilis Sweet snack as complement to conventional type 2 diabetes mellitus treatment. https://greenmedinfo.com/article/efficacy-lupinus-mutabilis-sweet-snack-complement-conventional-type-2-diabetes PMID:  Nutr Hosp. 2019 Aug 26 ;36(4):905-911. PMID: 31291739 Abstract Title:  Efficacy of a Lupinus mutabilis Sweet snack as complement to conventional type 2 diabetes mellitus treatment. Abstract:  Introduction: therapeutic lifestyles changes including frequent consumption of legumes have resulted in improved metabolic control and decreased blood pressure in type 2 diabetes-mellitus (T2DM) patients. Objective: this was a quasi-experimental-28-week crossover-study that assessed the effect of daily consumption of the legume Lupinus mutabilis (LM) on metabolic control of T2DM patients under hypoglycemic oral treatment. Material and methods: we recruited 79 adult male and female patients that were followed for 14-weeks without LM consumption and then received increasing doses of a LM-based-snack for other 14-weeks. Results: there was a significant decrease in blood pressure and a significant increase in HDL-cholesterol by the end of the study period. While patients with A1C concentrations&gt;8 and≤ 10 did not significantly improve their metabolic control, patients with serum A1C concentrations ≤ 8.0% reduced significantly their A1C after the intervention and 71% achieved a target concentration of 6.5%. Conclusion: patients with T2DM could benefit with the addition of LM-snack to their conventional treatment. <p><a href="https://greenmedinfo.com/article/efficacy-lupinus-mutabilis-sweet-snack-complement-conventional-type-2-diabetes" target="_blank">read more</a></p> https://greenmedinfo.com/article/efficacy-lupinus-mutabilis-sweet-snack-complement-conventional-type-2-diabetes#comments Diabetes Mellitus: Type 2 Lupine Hypoglycemic Agents Phytotherapy Human Study Tue, 03 Mar 2020 00:18:19 +0000 greenmedinfo 215147 at https://greenmedinfo.com In vitro assay of quinoa and lupin extracts on human platelet aggregation. https://greenmedinfo.com/article/vitro-assay-quinoa-and-lupin-extracts-human-platelet-aggregation PMID:  Plant Foods Hum Nutr. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32086676 Abstract Title:  In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation. Abstract:  Cardiovascular disease (CVD) is the leading cause of death throughout the world. A major risk factor for CVD is platelet aggregation. Various plant extracts exhibit anti-aggregatory action in vitro. The dietary intake of traditional plant crops such as quinoa (Chenopodium quinoa Willd) and lupin (Lupinus spp., Fabaceae family), highly recognized for their high nutritional value, is increasing worldwide. The aim of the study was to assay possible antiplatelet effects of quinoa and lupin bean extracts in vitro. The proximate chemical composition of quinoa grains and the three most widely known lupin cultivars: blue (L. angustifolius), yellow (L. luteus or mutabilis) and white (L. albus) grown in Chile were analyzed. The anti-aggregation activity of the ethanol extracts of the crops was assayed using flow cytometry in ADP-stimulated human platelets, and their inhibition of the maximal platelet aggregation was measured. All the lupin extracts exhibited a significant anti-aggregatory effect (p <p><a href="https://greenmedinfo.com/article/vitro-assay-quinoa-and-lupin-extracts-human-platelet-aggregation" target="_blank">read more</a></p> https://greenmedinfo.com/article/vitro-assay-quinoa-and-lupin-extracts-human-platelet-aggregation#comments Cardiovascular Disease Lupine Quinoa Cardioprotective In Vitro Study Mon, 02 Mar 2020 16:26:41 +0000 greenmedinfo 215058 at https://greenmedinfo.com Lupine protein hydrolysates decrease the inflammatory response and improve the oxidative status in human peripheral lymphocytes. https://greenmedinfo.com/article/lupine-protein-hydrolysates-decrease-inflammatory-response-and-improve-oxidati PMID:  Food Res Int. 2019 Dec ;126:108585. Epub 2019 Jul 27. PMID: 31732051 Abstract Title:  Lupine protein hydrolysates decrease the inflammatory response and improve the oxidative status in human peripheral lymphocytes. Abstract:  Although cell-free systems and immortalized cell lines have been used to demonstrate the potential health benefits of lupine proteins and peptides, no study has examined the effects of lupine protein hydrolysates (LPHs) on the immune and oxidative responses of non-immortalized human cells. Therefore, the aims of this study were to evaluate the effects of the in vitro administration of LPHs from Lupinus angustifolius on the immunological and oxidative statuses of human peripheral blood mononuclear cells (PBMCs) from 53 healthy donors. LPHs reduced PBMCs proliferation and the levels of Th1, Th9 and Th17 pro-inflammatory cytokines without being cytotoxic. LPHs also skewed the pro-/anti-inflammatory balance towards a Th2 protective response. Additionally, LPHs increased superoxide dismutase and catalase activities, and the total antioxidant capacity (TAC). This study is the first to show that LPHs reduce T cell inflammatory responses and improve the anti-inflammatory/pro-inflammatory cytokine balance and the TAC by PBMCs. Thus, LPHs may represent an effective option for developing nutritional strategies to prevent pathologies with underlying inflammation and oxidative stress. <p><a href="https://greenmedinfo.com/article/lupine-protein-hydrolysates-decrease-inflammatory-response-and-improve-oxidati" target="_blank">read more</a></p> https://greenmedinfo.com/article/lupine-protein-hydrolysates-decrease-inflammatory-response-and-improve-oxidati#comments Inflammation Lupine Oxidative Stress Anti-Inflammatory Agents Antioxidants In Vitro Study Tue, 03 Mar 2020 00:08:39 +0000 greenmedinfo 215146 at https://greenmedinfo.com Lupinus mutabilis edible beans protect against bacterial infection in uroepithelial cells. https://greenmedinfo.com/article/lupinus-mutabilis-edible-beans-protect-against-bacterial-infection-uroepitheli PMID:  Evid Based Complement Alternat Med. 2018 ;2018:1098015. Epub 2018 Dec 16. PMID: 30643523 Abstract Title:  Edible Beans Protect against Bacterial Infection in Uroepithelial Cells. Abstract:  is a South American herb with edible beans, known to reduce serum glucose levels in diabetic patients. Furthermore,contains phytochemicals known to decrease bacterial load. Based on the increased urinary tract infections experienced among patients with diabetes, we investigated the effect ofon bladder epithelial cells in the protection ofinfection during normal and high glucose concentrations. We did not observe any direct antibacterial effect byextract. Instead we observed an influence on the host cells, with indirect impact on bacteria and their possibility of causing infection.extract decreased adhesion to bladder epithelial cells of uropathogenic bacteria, including drug-resistant strains. Moreover, uroplakin1a, involved in adhesion, was downregulated while the antimicrobial peptide RNase 7 was upregulated intreated cells irrespectively of glucose concentration. This supports an early effect fighting bacteria. Additionally,prevented bacterial biofilm formation, which is used by bacteria to evade the immune system and antibiotics. In summary,protects against bacterial infection in uroepithelial cells by preventing adhesion through alteration of the cell surface, increasing antimicrobial peptide expression, and reducing biofilm formation. Together, this promotes bacterial clearance, suggesting thatas extract or as a dietary item can contribute to the prevention of urinary tract infections, which is of importance in an era of increasing antibiotic resistance. <p><a href="https://greenmedinfo.com/article/lupinus-mutabilis-edible-beans-protect-against-bacterial-infection-uroepitheli" target="_blank">read more</a></p> https://greenmedinfo.com/article/lupinus-mutabilis-edible-beans-protect-against-bacterial-infection-uroepitheli#comments Bacterial Infections Lupine Anti-Bacterial Agents In Vitro Study Tue, 03 Mar 2020 00:29:00 +0000 greenmedinfo 215148 at https://greenmedinfo.com Lupinus mutabilis extract exerts an anti-diabetic effect by improving insulin release in type 2 diabetic Goto-Kakizaki rats. https://greenmedinfo.com/article/lupinus-mutabilis-extract-exerts-anti-diabetic-effect-improving-insulin-releas PMID:  Nutrients. 2018 Jul 20 ;10(7). Epub 2018 Jul 20. PMID: 30037028 Abstract Title:  Extract Exerts an Anti-Diabetic Effect by Improving Insulin Release in Type 2 Diabetic Goto-Kakizaki Rats. Abstract:  () is a legume part of Bolivian traditional diet that has a nutraceutical property reducing blood glucose levels. The prevalence of type 2 diabetes is increasing worldwide thus; the search for novel anti-diabetic drugs is needed. Based on its traditional use, we evaluated the anti-diabetic effect ofin the spontaneously diabetic Goto-Kakizaki (GK) rat, a model of type 2 diabetes and in Wistar (W) rats as healthy control.seeds hydroethanolic extract, analyzed by gas chromatography-mass spectrometry and high-performance liquid chromatography-high resolution mass spectrometry, is a complex mixture of volatile and non-volatile components. A single oral administration ofextract (2000 mg/kg b.w.) improved glucose tolerance during the oral glucose tolerance test (OGTT) (30⁻120 min) in GK and W rats (<p><a href="https://greenmedinfo.com/article/lupinus-mutabilis-extract-exerts-anti-diabetic-effect-improving-insulin-releas" target="_blank">read more</a></p> https://greenmedinfo.com/article/lupinus-mutabilis-extract-exerts-anti-diabetic-effect-improving-insulin-releas#comments Diabetes Mellitus: Type 2 Lupine Hypoglycemic Agents Phytotherapy Plant Extracts Animal Study Tue, 03 Mar 2020 00:33:56 +0000 greenmedinfo 215149 at https://greenmedinfo.com Mango leaf extract with quercetin attenuates muscle damage and accelerates recovery after strenuous exercise. https://greenmedinfo.com/article/mango-leaf-extract-quercetin-attenuates-muscle-damage-and-accelerates-recovery PMID:  Nutrients. 2020 Feb 26 ;12(3). Epub 2020 Feb 26. PMID: 32110986 Abstract Title:  Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise. Abstract:  Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 hours thereafter for 24 hours, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated themuscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u.,= 0.035) and the loss of jumping performance (9.4± 11.5 and 3.9 ± 5.2%,= 0.036;= 0.034) and mechanical impulse (= 0.038) 24 hours later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction<p><a href="https://greenmedinfo.com/article/mango-leaf-extract-quercetin-attenuates-muscle-damage-and-accelerates-recovery" target="_blank">read more</a></p> https://greenmedinfo.com/article/mango-leaf-extract-quercetin-attenuates-muscle-damage-and-accelerates-recovery#comments Lupine Muscle Damage: Exercise-Induced Quercetin Human Study Tue, 03 Mar 2020 00:41:15 +0000 greenmedinfo 215153 at https://greenmedinfo.com Narrow-leafed lupin seeds gamma-conglutin is an anti-inflammatory protein promoting insulin resistance improvement and oxidative stress. https://greenmedinfo.com/article/narrow-leafed-lupin-seeds-gamma-conglutin-anti-inflammatory-protein-promoting- PMID:  Antioxidants (Basel). 2019 Dec 23 ;9(1). Epub 2019 Dec 23. PMID: 31877933 Abstract Title:  Narrow-Leafed Lupin (L.) Seeds Gamma-Conglutin is an Anti-Inflammatory Protein Promoting Insulin Resistance Improvement and Oxidative Stress Amelioration in PANC-1 Pancreatic Cell-Line. Abstract:  (1) Background: Inflammation molecular cues and insulin resistance development are some of the main contributors for the development and advance of the pathogenesis of inflammatory-related diseases; (2) Methods: We isolated and purifiedγ-conglutin protein from narrow-leafed lupin (NLL or blue lupin) mature seeds using affinity-chromatography to evaluate its anti-inflammatory activities at molecular level using both, a bacterial lipopolysaccharide (LPS)-induced inflammation and an insulin resistance pancreatic cell models; (3) Results: NLL γ-conglutin achieved a plethora of functional effects as the strong reduction of cell oxidative stress induced by inflammation through decreasing proteins carbonylation, nitric oxide synthesis and inducible nitric oxide synthase (iNOS) transcriptional levels, and raising glutathione (GSH)levels and modulation of superoxide dismutase (SOD) and catalase enzymes activities. γ-conglutin induced up-regulated transcriptomic and protein levels of insulin signalling pathway IRS-1, Glut-4, and PI3K, improving glucose uptake, while decreasing pro-inflammatory mediators as iNOs, TNFα, IL-1β, INFγ, IL-6, IL-12, IL-17, and IL-27; (4) Conclusion: These results suggest a promising use of NLL γ-conglutin protein in functional foods, which could also be implemented in alternative diagnosis and therapeutic molecular tools helping to prevent and treat inflammatory-related diseases. <p><a href="https://greenmedinfo.com/article/narrow-leafed-lupin-seeds-gamma-conglutin-anti-inflammatory-protein-promoting-" target="_blank">read more</a></p> https://greenmedinfo.com/article/narrow-leafed-lupin-seeds-gamma-conglutin-anti-inflammatory-protein-promoting-#comments Inflammation Lupine Oxidative Stress Anti-Inflammatory Agents Interleukin-1 beta downregulation Interleukin-12 downregulation Interleukin-17 downregulation Interleukin-6 Downregulation Tumor Necrosis Factor (TNF) Alpha Inhibitor In Vitro Study Mon, 02 Mar 2020 18:22:38 +0000 greenmedinfo 215123 at https://greenmedinfo.com Report of brain damage caused by crude quinolizidine alkaloid extracts from lupines. https://greenmedinfo.com/article/report-brain-damage-caused-crude-quinolizidine-alkaloid-extracts-lupines PMID:  Histol Histopathol. 2005 Oct ;20(4):1147-53. PMID: 16136497 Abstract Title:  Histological evaluation of brain damage caused by crude quinolizidine alkaloid extracts from lupines. Abstract:  The effects of the intracerebroventricular (ICV) administration of crude extracts of lupin quinolizidine alkaloids (LQAs) were studied in adult rat brain tissue. Mature L. exaltatus and L. montanus seeds were collected in western Mexico, and the LQAs from these seeds were extracted and analyzed by capillary gas chromatography. This LQA extract was administered to the right lateral ventricle of adult rats through a stainless steel cannula on five consecutive days. While control animals received 10 microl of sesame oil daily (vehicle), the experimental rats (10 per group) received 20 ng of LQA from either L. exaltatus or from L. montanus. All the animals were sacrificed 40 h after receiving the last dose of alkaloids, and their brains were removed, fixed and coronal paraffin sections were stained with haematoxylin and eosin. Immediately after the administration of LQA the animals began grooming and suffered tachycardia, tachypnea, piloerection, tail erection, muscular contractions, loss of equilibrium, excitation, and unsteady walk. In the brains of the animals treated with LQA damaged neurons were identified. The most frequent abnormalities observed in this brain tissue were&quot;red neurons&quot;with shrunken eosinophilic cytoplasm, strongly stained pyknotic nuclei, neuronal swelling, spongiform neuropil,&quot;ghost cells&quot;(hypochromasia), and abundant neuronophagic figures in numerous brain areas. While some alterations in neurons were observed in control tissues, unlike those found in the animals treated with LQA these were not significant. Thus, the histopathological changes observed can be principally attributed to the administration of sparteine and lupanine present in the alkaloid extracts. https://greenmedinfo.com/article/report-brain-damage-caused-crude-quinolizidine-alkaloid-extracts-lupines#comments Brain Damage Lupine Seizures Plant Extracts Animal Study Sun, 01 Apr 2012 15:51:33 +0000 greenmedinfo 73814 at https://greenmedinfo.com Yellow lupin polysaccharides: Antioxidant, immunomodulatory and prebiotic activities and their structural characterisation. https://greenmedinfo.com/article/yellow-lupin-polysaccharides-antioxidant-immunomodulatory-and-prebiotic-activi PMID:  Food Chem. 2018 Nov 30 ;267:319-328. Epub 2018 Feb 21. PMID: 29934174 Abstract Title:  Yellow lupin (Lupinus luteus L.) polysaccharides: Antioxidant, immunomodulatory and prebiotic activities and their structural characterisation. Abstract:  Yellow lupin polysaccharides (YLP-1, YLP-2 and YLP-3) were isolated from the whole seeds of Lupinus luteus L. Their antioxidant activities were evaluated by ABTSand hydroxyl radical scavenging, and Fechelating assays. Immunostimulatory activities were measured by their ability to activate macrophages to produce TNF-α and NO. Four strains of probiotic bacteria were used to measure their prebiotic activities. YLP-2 with largest galactose content displayed the best activity amongst the three isolated polysaccharides. NMR and FT-IR spectroscopic methods have revealed that YLPs contain galactans and galactomannanswhich are linked with β-(1,4) glycosidic bond in the main chain. The side chain Galp unit of galactomannan is connected to the main chain Manp by α-(1,6) linkage. The results presented in this paper strongly suggest that YLPs display significant antioxidant, immunostimulatory and prebiotic activities and hence hold great potential as nutraceutical and functional agents. <p><a href="https://greenmedinfo.com/article/yellow-lupin-polysaccharides-antioxidant-immunomodulatory-and-prebiotic-activi" target="_blank">read more</a></p> https://greenmedinfo.com/article/yellow-lupin-polysaccharides-antioxidant-immunomodulatory-and-prebiotic-activi#comments Lupine Prebiotics Antioxidants Gastrointestinal Agents Immunomodulatory Polysaccharides Animal Study Tue, 03 Mar 2020 00:36:41 +0000 greenmedinfo 215151 at https://greenmedinfo.com