Dietary Modification: Low Carbohydrate/Ketogenic

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66 Diseases Researched for Dietary Modification: Low Carbohydrate/Ketogenic
NameACCKFocus
Epilepsy: Childhood770Locked
Epilepsy1157Locked
Seizures850Locked
Cancers: All533Locked
Epileptic Seizures321Locked
Autism Spectrum Disorders620Locked
Dravet syndrome220Locked
Lennox-Gastaut Syndrome220Locked
Epilepsy: Infant213Locked
Parkinson's Disease313Locked
Headache: Migraine211Locked
Chronic Kidney Disease (CKD)110Locked
Chronic Obstructive Pulmonary Disease110Locked
Diabetes Mellitus: Type 2110Locked
Diabetes: Glycation/A1C110Locked
Encephalopathy110Locked
Fatty Liver110Locked
Glioblastoma110Locked
Glucose Transporter 1 Deficiency Syndrome110Locked
Head and Neck Cancer110Locked
Hepatic Steatosis110Locked
Infantile Spasms110Locked
Kidney Stones110Locked
Liver: Fatty110Locked
Metabolic Diseases110Locked
Multiple Sclerosis110Locked
Narcolepsy110Locked
Rett Syndrome110Locked
Tuberous Sclerosis110Locked
Amyotrophic lateral sclerosis (ALS)46Locked
Alzheimer's Disease45Locked
Neurologic Disorders35Locked
Brain Cancer44Locked
Glioma34Locked
Aspartate-glutamate carrier (AGC1) Deficiency 13Locked
Autism13Locked
Breast Cancer13Locked
Casein Intolerance13Locked
Congenital Disorders13Locked
Glioblastoma Multiforme13Locked
Gluten Sensitivity13Locked
Hyperinsulinism13Locked
Neurodegenerative Diseases33Locked
Aging12Locked
Autoimmune Diseases12Locked
Brain: Microglial Activation12Locked
Cancer Metastasis12Locked
Cognitive Decline/Dysfunction12Locked
Colon Cancer12Locked
Heart Disease: Ischemic12Locked
Huntington Disease12Locked
Kabuki Make-Up Syndrome12Locked
Multiple Sclerosis: Relapsing-Remitting 12Locked
Oxidative Stress12Locked
Prostate Cancer12Locked
Spinal Cord Injuries12Locked
Amyotrophic Lateral Sclerosis11Locked
Astrocytoma11Locked
Cardiovascular Diseases11Locked
Convulsive Seizures11Locked
Excitotoxicity 11Locked
Hemiplegia11Locked
Mitochondrial Diseases11Locked
Mood Disorders11Locked
Neuroblastoma11Locked
Thyroid Cancer11Locked
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View the Evidence:
81 Abstracts with Dietary Modification: Low Carbohydrate/Ketogenic Research

[+]

The ketone body, beta-hydroxybutyrate, associated with the low-carb diet and fasting may be responsible for the initial euphoria experienced by those undergoing these dietary modifications.Jan 01, 2007

Pubmed Data : Med Hypotheses. 2007;68(2):268-71. Epub 2006 Oct 2. PMID: 17011713
Article Published Date : Jan 01, 2007
Study Type : Meta Analysis
Additional Links
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Fasting/Caloric Restriction
[+]

There was an overall tumor growth delaying effect of unrestricted ketogenic diets in mice.Dec 31, 2015

Pubmed Data : PLoS One. 2016;11(5):e0155050. Epub 2016 May 9. PMID: 27159218
Article Published Date : Dec 31, 2015
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Median Survival Time, Risk Reduction
[+]

A ketogenic diet could help reduce the frequency of migraine attacks. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Headache Pain. 2016 ;17:58. Epub 2016 May 31. PMID: 27245682
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Headache: Migraine
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

Pubmed Data : Przegl Lek. 2010;67(3):205-12. PMID: 20687386
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

A ketogenic diet is an effective therapeutic modality for epilepsy associated with tuberous sclerosis in children. Oct 01, 2005

Pubmed Data : Epilepsia. 2005 Oct;46(10):1684-6. PMID: 16190943
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood, Tuberous Sclerosis
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A Ketogenic diet is effective in refractory epilepsy of childhood.Dec 13, 1901

Pubmed Data : Rev Neurol. 2001 Dec 1-15;33(11):1010-4. PMID: 11785025
Study Type : Human Study
Additional Links
Substances : Medium Chain Triglycerides
Diseases : Epilepsy: Childhood
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A low-carbohydrate, ketogenic diet improves fatty liver disease. Feb 01, 2007

Pubmed Data : Dig Dis Sci. 2007 Feb;52(2):589-93. Epub 2007 Jan 12. PMID: 17219068
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Diseases : Fatty Liver, Hepatic Steatosis, Liver: Fatty
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A low-carbohydrate, ketogenic reduces narcolepsy symptoms.Jun 22, 2004

Pubmed Data : Neurology. 2004 Jun 22;62(12):2300-2. PMID: 15210901
Article Published Date : Jun 22, 2004
Study Type : Human Study
Additional Links
Diseases : Narcolepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Both a modified Atkins diet and the classic ketogenic diet could be used in the treatment of intractable epilepsy in children.Dec 09, 2015

Pubmed Data : Epilepsia. 2015 Dec 10. Epub 2015 Dec 10. PMID: 26662710
Article Published Date : Dec 09, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Calorically restricted diets could be effective in reducing the anxiety and in improving motor behavior in girls with Rett Syndrome.Jun 01, 2009

Pubmed Data : Epilepsy Behav. 2009 Jun;15(2):133-41. Epub 2009 Feb 26. PMID: 19249385
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Diseases : Autism Spectrum Disorders, Rett Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Fasting/Caloric Restriction
[+]

Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumorsJan 09, 2017

Pubmed Data : J Neurooncol. 2017 Jan 10. Epub 2017 Jan 10. PMID: 28074323
Article Published Date : Jan 09, 2017
Study Type : Human Study
Additional Links
Diseases : Glioblastoma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Ketogenic diet is an important non-pharmacological treatment option for patients with intractable epilepsy associated with tuberous sclerosis complex.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Epilepsy Res. 2017 Jun ;7(1):45-49. Epub 2017 Jun 30. PMID: 28775955
Article Published Date : May 31, 2017
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Ketogenic diets administered as supportive measures during standard therapy are safe and might be helpful in preservation of muscle mass.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Res Notes. 2016 ;9(1):143. Epub 2016 Mar 5. PMID: 26946138
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Integrative Medicine
[+]

Modifiying the diet by increasing fat intake and lowering carbohydrate may have a therapeutic effect in COPD. Mar 01, 2003

Pubmed Data : Nutrition. 2003 Mar;19(3):229-32. PMID: 12620524
Article Published Date : Mar 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chronic Obstructive Pulmonary Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

People on a ketogenic diet should supplement selenium. Nov 20, 2016

Pubmed Data : Biol Trace Elem Res. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27873289
Article Published Date : Nov 20, 2016
Study Type : Human Study
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Potassium citrate reduces kidney-stone incidence in children treated with a ketogenic diet for intractable epilepsy. Aug 01, 2009

Pubmed Data : Pediatrics. 2009 Aug;124(2):e300-4. Epub 2009 Jul 13. PMID: 19596731
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Potassium
Diseases : Epilepsy: Childhood, Kidney Stones
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

Pubmed Data : Pediatr Neurol. 2015 Nov ;53(5):422-6. Epub 2015 Aug 8. PMID: 26476148
Article Published Date : Oct 31, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet could be implemented in medium resources countries and should be included in the management of children with intractable epilepsy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav Case Rep. 2019 ;11:35-38. Epub 2018 Nov 23. PMID: 30619711
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet has significant therapy value in treating drug-resistant childhood epilepsy.Sep 01, 2010

Pubmed Data : Seizure. 2010 Sep;19(7):404-8. Epub 2010 Jul 2. PMID: 20598586
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Diseases : Dravet syndrome, Epilepsy: Childhood, Infantile Spasms, Lennox-Gastaut Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet is a promising therapy for myoclonic status in non-progressive encephalopathy.Jul 10, 2017

Pubmed Data : Seizure. 2017 Jul 11 ;51:1-5. Epub 2017 Jul 11. PMID: 28743048
Article Published Date : Jul 10, 2017
Study Type : Human Study
Additional Links
Diseases : Encephalopathy, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : Significant Treatment Outcome
[+]

The ketogenic diet is an effective therapy for children with therapy-resistant epilepsy.Sep 30, 2015

Pubmed Data : Epilepsy Behav. 2015 Oct ;51:261-6. Epub 2015 Aug 24. PMID: 26301622
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet is highly effective and well tolerated in infants with epilepsy.Sep 30, 2015

Pubmed Data : Epilepsy Res. 2015 Oct ;116:53-8. Epub 2015 Jul 9. PMID: 26354167
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Infant, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet let to a decline in the lactate concentration in tumor tissue.Dec 31, 2012

Pubmed Data : Nutr Cancer. 2013 ;65(6):843-9. PMID: 23909728
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Diseases : Head and Neck Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Chemotherapeutic
[+]

The ketogenic diet may significantly decrease carbon dioxide body stores, which may theoretically be beneficial for patients with increased carbon dioxide arterial partial pressure.Sep 25, 2015

Pubmed Data : Lung. 2015 Sep 26. Epub 2015 Sep 26. PMID: 26410589
Article Published Date : Sep 25, 2015
Study Type : Human Study
Additional Links
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet normalized concentrations of the colonic microbiome in patients with multiple sclerosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2017 ;8:1141. Epub 2017 Jun 28. PMID: 28702003
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Multiple Sclerosis
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Microbiome
[+]

The ketogenic diet seems nutritionally safe and could defer dialysis initiation in some patients with chronic kidney disease.Jan 27, 2016

Pubmed Data : J Am Soc Nephrol. 2016 Jan 28. Epub 2016 Jan 28. PMID: 26823552
Article Published Date : Jan 27, 2016
Study Type : Human Study
Additional Links
Diseases : Chronic Kidney Disease (CKD)
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Dietary Modification: Vegetarian
Pharmacological Actions : Renoprotective
Additional Keywords : Risk Reduction
[+]

The ketogenic diet significantly improves quality of life, and reduces both seizures and medication needs in most patients wtih Dravet syndrome studied.Sep 01, 2005

Pubmed Data : Epilepsia. 2005 Sep;46(9):1539-44. PMID: 16146451
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Dravet syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : Drug Sparing
[+]

The ketogenic diet was beneficial for patients with GLUT-1 deficiency syndrome.Jan 13, 2016

Pubmed Data : Seizure. 2016 Jan 14 ;35:83-87. Epub 2016 Jan 14. PMID: 26803281
Article Published Date : Jan 13, 2016
Study Type : Human Study
Additional Links
Diseases : Epilepsy, Metabolic Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The long-term effects of a diet loosely restricting carbohydrates results in significantly improved HbA1c levels, blood lipid profiles and reduced drug requirements in type 2 diabetes. Feb 01, 2008

Pubmed Data : Diabetes Res Clin Pract. 2008 Feb;79(2):350-6. Epub 2007 Nov 5. PMID: 17980451
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Diseases : Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The results show that the ketogenic diet is effective in Lennox-Gastaut syndrome.Nov 30, 2016

Pubmed Data : Epilepsy Res. 2016 Dec ;128:176-180. Epub 2016 Nov 9. PMID: 27846468
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Diseases : Epilepsy, Lennox-Gastaut Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Three to 6 years after initiation, the ketogenic diet had proven to be effective in the control of difficult-to-control seizures in children.Sep 30, 2001

Pubmed Data : Pediatrics. 2001 Oct ;108(4):898-905. PMID: 11581442
Article Published Date : Sep 30, 2001
Study Type : Human Study
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Treatment with ketogenic diet resulted in a marked improvement in seizures and cognitive functions.Sep 30, 2015

Pubmed Data : Neuropediatrics. 2015 Oct ;46(5):313-20. Epub 2015 Aug 12. PMID: 26267703
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Glucose Transporter 1 Deficiency Syndrome, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Treatment with the ketogenic diet reduces the number of emergency department visits in children with refractory epilepsy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Res Treat. 2016 ;2016:5873208. Epub 2016 Sep 26. PMID: 27752367
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Risk Reduction
[+]

"Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases."Oct 31, 1992

Pubmed Data : Epilepsia. 1992 Nov-Dec;33(6):1132-6. PMID: 1464275
Article Published Date : Oct 31, 1992
Study Type : Human: Case Report
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A combination of high-dose vitamin D3 and ketogenic diet leads to changes in some biological markers of breast cancer.Sep 30, 2015

Pubmed Data : Anticancer Res. 2015 Oct ;35(10):5525-32. PMID: 26408720
Article Published Date : Sep 30, 2015
Study Type : Human: Case Report
Additional Links
Substances : Vitamin D
Diseases : Breast Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Supplementation
[+]

Autism and Dietary Therapy: Case Report and Review of the Literature.May 09, 2013

Pubmed Data : J Child Neurol. 2013 May 10. Epub 2013 May 10. PMID: 23666039
Article Published Date : May 09, 2013
Study Type : Human: Case Report
Additional Links
Substances : Medium Chain Triglycerides
Diseases : Autism, Autism Spectrum Disorders, Casein Intolerance, Gluten Sensitivity
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Dietary Modification: Wheat/Gluten Free
Problem Substances : Casein, Wheat
[+]

Management of glioblastoma multiforme in a patient treated with ketogenic metabolic therapy and modified standard of care: a 24-month follow-up.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2018 ;5:20. Epub 2018 Mar 29. PMID: 29651419
Article Published Date : Dec 31, 2017
Study Type : Human: Case Report
Additional Links
Substances : Vitamin D
Diseases : Glioblastoma Multiforme
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet compensates for AGC1 deficiency and improves myelination.Sep 23, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsia. 2015 Sep 24. Epub 2015 Sep 24. PMID: 26401995
Article Published Date : Sep 23, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Aspartate-glutamate carrier (AGC1) Deficiency , Epilepsy: Infant, Neurologic Disorders, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Significant Treatment Outcome
[+]

The ketogenic diet could represent an effective treatment to support brain function in selected cases of congenital hyperinsulinism.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Orphanet J Rare Dis. 2015 ;10(1):120. Epub 2015 Sep 24. PMID: 26399329
Article Published Date : Dec 31, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Congenital Disorders, Hyperinsulinism, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Significant Treatment Outcome
[+]

A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms.Jun 06, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Rep. 2016 Jun 7 ;15(10):2136-46. Epub 2016 May 26. PMID: 27239035
Article Published Date : Jun 06, 2016
Study Type : Animal Study
Additional Links
Diseases : Autoimmune Diseases, Multiple Sclerosis: Relapsing-Remitting
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Fasting/Caloric Restriction
Additional Keywords : Dietary Modification
[+]

A ketogenic diet delays weight loss and does not impair working memory or motor function in the mouse model of Huntington's disease.Apr 09, 2011

Pubmed Data : Physiol Behav. 2011 Apr 9;103(5):501-507. Epub 2011 Apr 9. PMID: 21501628
Article Published Date : Apr 09, 2011
Study Type : Animal Study
Additional Links
Diseases : Huntington Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Aging Neurosci. 2018 ;10:391. Epub 2018 Dec 3. PMID: 30559660
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Aging, Cognitive Decline/Dysfunction
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

A ketogenic diet in combination with nutritrional supplementation has remarkable therapeutic properties in a rodent model of ALS. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e103526. Epub 2014 Jul 25. PMID: 25061944
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Arginine-alpha-ketoglutarate (AAKG), Coenzyme Q10, GABA (gamma-Aminobutyric Acid), Medium Chain Triglycerides
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.Jan 02, 2017

Pubmed Data : Proc Natl Acad Sci U S A. 2017 Jan 3 ;114(1):125-130. Epub 2016 Dec 20. PMID: 27999180
Article Published Date : Jan 02, 2017
Study Type : Animal Study
Additional Links
Diseases : Kabuki Make-Up Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

A low carbohydrate ketogenic diet is cardioprotective following global ischemic injury. Aug 01, 2007

Pubmed Data : Acta Cardiol. 2007 Aug;62(4):381-9. PMID: 17824299
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Heart Disease: Ischemic
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A low carbohydrate/ketogenic diet inhibits prostate cancer progression in an animal model. Mar 06, 2012

Pubmed Data : BJU Int. 2012 Mar 6. Epub 2012 Mar 6. PMID: 22394625
Article Published Date : Mar 06, 2012
Study Type : Transgenic Animal Study
Additional Links
Diseases : Prostate Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A novel combination of ketogenic diet, ketone supplementation and hyperbaric oxygen therapy could be used to manage metastatic cancers.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(6):e0127407. Epub 2015 Jun 10. PMID: 26061868
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ketone Bodies
Diseases : Cancer Metastasis
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Hyperbaric Treatment, Integrative Medicine
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic
[+]

Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(5):2061-8. PMID: 25773851
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Colon Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Antiproliferative
[+]

Ketogenic and related diets may provide significant relief from the core symptoms of autism spectrum disorders.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Behav. 2017 Jan 1 ;168:138-145. Epub 2016 Nov 9. PMID: 27836684
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Autism Spectrum Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Ketogenic diet therapy might be uniquely suited to reset the epileptogenic clock and to provide long-lasting relief from seizures even after discontinuation of the diet.Aug 05, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropharmacology. 2015 Aug 6 ;99:500-509. Epub 2015 Aug 6. PMID: 26256422
Article Published Date : Aug 05, 2015
Study Type : Animal Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : DNA Methylation, Epigenetic Modification
[+]

Ketogenic metabolism inhibits histone deacetylase and reduces oxidative stress after spinal cord injury.Dec 15, 2017

Pubmed Data : Neuroscience. 2017 Dec 16 ;366:36-43. Epub 2017 Oct 9. PMID: 29024787
Article Published Date : Dec 15, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents
[+]

The ketogenic diet may work as an immune adjuvant in the glioma microenvironment by reducing immune suppression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2016 ;16:310. Epub 2016 May 13. PMID: 27178315
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Immunomodulatory, Immunostimulatory
[+]

The ketogenic diet was neuroprotective and anti-inflammatory against MPTP-neurotoxicity.Sep 30, 2010

Pubmed Data : J Mol Neurosci. 2010 Oct ;42(2):145-53. Epub 2010 Mar 24. PMID: 20333481
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Brain: Microglial Activation, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

These findings may explain, in part, the ability of a KD to mitigate some of the neurological symptoms associated with ASD.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Autism. 2016 ;7(1):37. Epub 2016 Sep 1. PMID: 27594980
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Autism Spectrum Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Microbiota
[+]

This data indicates that skeletal muscle mitochondrial coupling of complex II substrates is more efficient in chronically resistance trained rodents fed a KD.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2016 ;7:533. Epub 2016 Nov 8. PMID: 27877138
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Exercise: Resistance Training
[+]

This study demonstrates the clear benefits of ketogenic diet in the maternal immune activation model of autism spectrum disorder.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(2):e0171643. Epub 2017 Feb 6. PMID: 28166277
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Autism Spectrum Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

"The ketogenic diet: mechanism of anticonvulsant action."Dec 31, 1979

Pubmed Data : Adv Neurol. 1980 ;27:635-42. PMID: 6990715
Article Published Date : Dec 31, 1979
Study Type : Review
Additional Links
Diseases : Convulsive Seizures, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A high fat/low carbohydrate ketogenic diet is therapeutic in an animal model of brain cancer. Feb 21, 2007

Pubmed Data : Nutr Metab (Lond). 2007 Feb 21;4:5. PMID: 17313687
Article Published Date : Feb 21, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Astrocytoma, Brain Cancer, Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A keto-mediet approach with coconut substitution and exercise may delay the onset of Alzheimer's disease.Dec 31, 2016

Pubmed Data : J Prev Alzheimers Dis. 2017 ;4(1):51-57. PMID: 29188860
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Coconut
Diseases : Alzheimer's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Exercise
Pharmacological Actions : Neuroprotective Agents
[+]

A ketogenic diet may suppress neuronal hyperexcitability in patients with epilepsy. Dec 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Dec;53(12):1603-11. PMID: 16059506
Article Published Date : Dec 01, 2009
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A review of ketogenic diets in the treatment of epilepsy.Aug 08, 2017

Pubmed Data : Curr Pharm Des. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28799513
Article Published Date : Aug 08, 2017
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A review of the association between diet and mood.Dec 03, 2018

Pubmed Data : Psychiatry Res. 2018 Dec 4 ;271:428-437. Epub 2018 Dec 4. PMID: 30537665
Article Published Date : Dec 03, 2018
Study Type : Review
Additional Links
Diseases : Mood Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

An overview of the Ketogenic diet and childhood neurological disorders other than epilepsy.Nov 20, 2016

Pubmed Data : Expert Rev Neurother. 2016 Nov 21:1-13. Epub 2016 Nov 21. PMID: 27841033
Article Published Date : Nov 20, 2016
Study Type : Review
Additional Links
Diseases : Autism Spectrum Disorders, Headache: Migraine, Hemiplegia, Neurologic Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Calorically restricted ketogenic diets may provide an alternative therapy to brain cancer. Nov 01, 2008

Pubmed Data : Epilepsia. 2008 Nov;49 Suppl 8:114-6. PMID: 19049606
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Brain Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Deuterium depletion in water offers a new adjuvant and protective cancer therapy.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Hypotheses. 2016 Feb ;87:69-74. Epub 2015 Nov 26. PMID: 26826644
Article Published Date : Jan 31, 2016
Study Type : Commentary
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Chemotherapeutic
[+]

Dietary manipulation through the elimination of glucose and/or a ketogenic diet may be therapeutic in the treatment of brain ccancer. Jan 01, 2009

Pubmed Data : J Pediatr Surg. 2009 Jan;44(1):212-6; discussion 216. PMID: 19159745
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Brain Cancer, Neuroblastoma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

High-fat and ketogenic diets may have value in treating amyotrophic lateral sclerosis.Jul 31, 2013

Pubmed Data : J Child Neurol. 2013 Aug ;28(8):989-92. Epub 2013 May 10. PMID: 23666040
Article Published Date : Jul 31, 2013
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Dietary Modification: High-Fat/Low-Carbohydrate , Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Metabolic therapy: a new paradigm for managing malignant brain cancer.Jan 27, 2015

Pubmed Data : Cancer Lett. 2015 Jan 28 ;356(2 Pt A):289-300. Epub 2014 Jul 25. PMID: 25069036
Article Published Date : Jan 27, 2015
Study Type : Review
Additional Links
Diseases : Brain Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Overview of studies using ketogenic diets to treat various neurological disorders.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2012 ;3:59. Epub 2012 Apr 9. PMID: 22509165
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Diseases : Neurologic Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

The emerging data provide strong support for the use of a ketogenic diet in the treatment of malignant gliomas.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Neurosci. 2016 ;9:122. Epub 2016 Nov 16. PMID: 27899882
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Angiogenesis Inhibitors, Chemosensitizer, Radiosensitizer
[+]

The ketogenic diet and vitamin C have a potential role in the management of advanced differentiated thyroid cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2017 ;7:160. Epub 2017 Jul 25. PMID: 28791253
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Thyroid Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Chemotherapeutic
[+]

The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease.Oct 09, 2018

Pubmed Data : Nutrition. 2018 Oct 10 ;60:118-121. Epub 2018 Oct 10. PMID: 30554068
Article Published Date : Oct 09, 2018
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

The ketogenic diet leads to increases in circulating ketones, which may contribute to the efficacy in treating pharmacoresistant seizures.Jan 21, 2016

Pubmed Data : Cold Spring Harb Perspect Med. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801895
Article Published Date : Jan 21, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet may alter brain handling of glutamate, an excitotoxin, through enhanced conversion to glutamine and then to GABA. Nov 01, 2008

Pubmed Data : Epilepsia. 2008 Nov;49 Suppl 8:73-5. PMID: 19049594
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Excitotoxicity
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet may have therapeutic value in neuromuscular and neurodegenerative Diseases.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:474296. Epub 2014 Jul 3. PMID: 25101284
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Mitochondrial Diseases, Neurodegenerative Diseases, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet may have value in ALS. Jun 30, 2011

Pubmed Data : Neurol Neurochir Pol. 2011 Jul-Aug;45(4):370-8. PMID: 22101998
Article Published Date : Jun 30, 2011
Study Type : Review
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The results obtained from animal models are encouraging and show that ketogenic diet presents a viable option as an adjunct therapy for cancer.Dec 31, 2015

Pubmed Data : Recent Results Cancer Res. 2016;207:233-40. PMID: 27557542
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Cancers: All, Dietary Modification: Low Carbohydrate/Ketogenic, high fat diet, ketogenic diet
[+]

The scientific literature involving the ketogenic diet strongly supports the notion that epilepsy may indeed in part represent a metabolic disease.Jul 25, 2015

Pubmed Data : Neurosci Lett. 2015 Jul 26. Epub 2015 Jul 26. PMID: 26222258
Article Published Date : Jul 25, 2015
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

This proposes the use of the ketogenic diet as an effective and efficient preliminary and long-term treatment.Sep 27, 2016

Pubmed Data : Amino Acids. 2016 Sep 28. Epub 2016 Sep 28. PMID: 27683025
Article Published Date : Sep 27, 2016
Study Type : Review
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

This review summarizes the history of the KD and the principles and efficacy of the classic ketogenic diet.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arq Neuropsiquiatr. 2016 Oct ;74(10):842-848. PMID: 27759811
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

This reviews the potential epigenetic processes that may link lifespan to age-related diseases, particularly in the context of ketogenic diets.Nov 20, 2016

Pubmed Data : Mol Cell Endocrinol. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27884781
Article Published Date : Nov 20, 2016
Study Type : Review
Additional Links
Diseases : Cancers: All, Cardiovascular Diseases, Neurodegenerative Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Epigenetic Modification

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