Dietary Modification: Low Carbohydrate/Ketogenic

Name	AC	CK
Epilepsy: Childhood	7	70
Epilepsy	11	57
Seizures	8	50
Cancers: All	5	33
Epileptic Seizures	3	21
Autism Spectrum Disorders	6	20
Dravet syndrome	2	20
Lennox-Gastaut Syndrome	2	20
Epilepsy: Infant	2	13
Parkinson's Disease	3	13
Headache: Migraine	2	11
Chronic Kidney Disease (CKD)	1	10
Chronic Obstructive Pulmonary Disease	1	10
Diabetes Mellitus: Type 2	1	10
Diabetes: Glycation/A1C	1	10
Encephalopathy	1	10
Fatty Liver	1	10
Glioblastoma	1	10
Glucose Transporter 1 Deficiency Syndrome	1	10
Head and Neck Cancer	1	10
Hepatic Steatosis	1	10
Infantile Spasms	1	10
Kidney Stones	1	10
Liver: Fatty	1	10
Metabolic Diseases	1	10
Multiple Sclerosis	1	10
Narcolepsy	1	10
Rett Syndrome	1	10
Tuberous Sclerosis	1	10
Amyotrophic lateral sclerosis (ALS)	4	6
Alzheimer's Disease	4	5
Neurologic Disorders	3	5
Brain Cancer	4	4
Glioma	3	4
Aspartate-glutamate carrier (AGC1) Deficiency	1	3
Autism	1	3
Breast Cancer	1	3
Casein Intolerance	1	3
Congenital Disorders	1	3
Glioblastoma Multiforme	1	3
Gluten Sensitivity	1	3
Hyperinsulinism	1	3
Neurodegenerative Diseases	3	3
Aging	1	2
Autoimmune Diseases	1	2
Brain: Microglial Activation	1	2
Cancer Metastasis	1	2
Cognitive Decline/Dysfunction	1	2
Colon Cancer	1	2
Heart Disease: Ischemic	1	2
Huntington Disease	1	2
Kabuki Make-Up Syndrome	1	2
Multiple Sclerosis: Relapsing-Remitting	1	2
Oxidative Stress	1	2
Prostate Cancer	1	2
Spinal Cord Injuries	1	2
Amyotrophic Lateral Sclerosis	1	1
Astrocytoma	1	1
Cardiovascular Diseases	1	1
Convulsive Seizures	1	1
Excitotoxicity	1	1
Hemiplegia	1	1
Mitochondrial Diseases	1	1
Mood Disorders	1	1
Neuroblastoma	1	1
Thyroid Cancer	1	1

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Impact of a ketogenic diet on metabolic parameters in patients with obesity or overweight and with or without type 2 diabetes.Jul 05, 2020

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Pubmed Data : Nutrients. 2020 Jul 6 ;12(7). Epub 2020 Jul 6. PMID: 32640608

Article Published Date : Jul 05, 2020

Study Type : Meta Analysis

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Diseases : Diabetes Mellitus: Type 2, Obesity

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Hypolipidemic

Additional Keywords : Anti-Obesity Agents

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The ketone body, beta-hydroxybutyrate, associated with the low-carb diet and fasting may be responsible for the initial euphoria experienced by those undergoing these dietary modifications.Jan 01, 2007

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Pubmed Data : Acta Med Port. 2019 Dec 2 ;32(12):760-766. Epub 2019 Dec 2. PMID: 31851885

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Pubmed Data : Antioxidants (Basel). 2019 Dec 13 ;8(12). Epub 2019 Dec 13. PMID: 31847149

Article Published Date : Dec 12, 2019

Study Type : Human Study

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Diseases : Obesity

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Additional Keywords : Anti-Obesity Agents

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Ketogenic diet is an important non-pharmacological treatment option for patients with intractable epilepsy associated with tuberous sclerosis complex.May 31, 2017

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Pubmed Data : Int J Mol Sci. 2020 May 2 ;21(9). Epub 2020 May 2. PMID: 32370212

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Pubmed Data : Seizure. 2016 Jan 14 ;35:83-87. Epub 2016 Jan 14. PMID: 26803281

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Pubmed Data : Nutr Cancer. 2019 Jul 27:1-11. Epub 2019 Jul 27. PMID: 31352797

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Pubmed Data : Neuropediatrics. 2015 Oct ;46(5):313-20. Epub 2015 Aug 12. PMID: 26267703

Article Published Date : Sep 30, 2015

Study Type : Human Study

Additional Links

Diseases : Glucose Transporter 1 Deficiency Syndrome, Seizures

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anticonvulsants

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Treatment with the ketogenic diet reduces the number of emergency department visits in children with refractory epilepsy.Dec 31, 2015

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Pubmed Data : Epilepsy Res Treat. 2016 ;2016:5873208. Epub 2016 Sep 26. PMID: 27752367

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Diseases : Epilepsy

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Additional Keywords : Risk Reduction

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Very-low-calorie ketogenic diet as a safe and valuable tool for long-term glycemic management in patients with obesity and type 2 diabetes.Feb 25, 2021

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Pubmed Data : Nutrients. 2021 Feb 26 ;13(3). Epub 2021 Feb 26. PMID: 33652834

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Pubmed Data : J Child Neurol. 2013 May 10. Epub 2013 May 10. PMID: 23666039

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Pubmed Data : Epilepsia. 2015 Sep 24. Epub 2015 Sep 24. PMID: 26401995

Article Published Date : Sep 23, 2015

Study Type : Human: Case Report

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Diseases : Aspartate-glutamate carrier (AGC1) Deficiency , Epilepsy: Infant, Neurologic Disorders, Seizures

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Significant Treatment Outcome

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The ketogenic diet could represent an effective treatment to support brain function in selected cases of congenital hyperinsulinism.Dec 31, 2014

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Pubmed Data : Nutrition. 2019 Nov 27 ;72:110659. Epub 2019 Nov 27. PMID: 31986320

Article Published Date : Nov 26, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Breast Cancer

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Natural Substance Synergy

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A ketogenic diet delays weight loss and does not impair working memory or motor function in the mouse model of Huntington's disease.Apr 09, 2011

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Pubmed Data : PLoS One. 2015 ;10(6):e0127407. Epub 2015 Jun 10. PMID: 26061868

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Ketone Bodies

Diseases : Cancer Metastasis

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Hyperbaric Treatment, Integrative Medicine

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic

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Aberrant mitochondrial morphology and function in the BTBR mouse model of autism is improved by two weeks of ketogenic diet.May 04, 2020

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Pubmed Data : Int J Mol Sci. 2020 May 5 ;21(9). Epub 2020 May 5. PMID: 32380723

Article Published Date : May 04, 2020

Study Type : Animal Study

Additional Links

Diseases : Autism

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Gastrointestinal Agents

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Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model.Dec 31, 2014

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Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(5):2061-8. PMID: 25773851

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Pubmed Data : J Mol Neurosci. 2010 Oct ;42(2):145-53. Epub 2010 Mar 24. PMID: 20333481

Article Published Date : Sep 30, 2010

Study Type : Animal Study

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Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Brain: Microglial Activation, Parkinson's Disease

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Neuroprotective Agents

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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These findings may explain, in part, the ability of a KD to mitigate some of the neurological symptoms associated with ASD.Dec 31, 2015

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Pubmed Data : Int J Oncol. 2020 Feb ;56(2):606-617. Epub 2019 Dec 13. PMID: 31894296

Article Published Date : Jan 31, 2020

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Pubmed Data : Psychiatry Res. 2018 Dec 4 ;271:428-437. Epub 2018 Dec 4. PMID: 30537665

Article Published Date : Dec 03, 2018

Study Type : Review

Additional Links

Diseases : Mood Disorders

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

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A review of the ketogenic diet for the treatment and prevention of dementia.Jan 29, 2020

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Pubmed Data : J Geriatr Psychiatry Neurol. 2020 Jan 30:891988720901785. Epub 2020 Jan 30. PMID: 31996078

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Pubmed Data : Med Hypotheses. 2016 Feb ;87:69-74. Epub 2015 Nov 26. PMID: 26826644

Article Published Date : Jan 31, 2016

Study Type : Commentary

Additional Links

Substances : Water: Deuterium Depleted

Diseases : Cancers: All

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Chemotherapeutic

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Dietary manipulation through the elimination of glucose and/or a ketogenic diet may be therapeutic in the treatment of brain ccancer. Jan 01, 2009

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Pubmed Data : J Pediatr Surg. 2009 Jan;44(1):212-6; discussion 216. PMID: 19159745

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : Brain Cancer, Neuroblastoma

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

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Emerging roles for the intestinal microbiome in epilepsy.Aug 20, 2019

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Pubmed Data : Neurobiol Dis. 2019 Aug 21:104576. Epub 2019 Aug 21. PMID: 31445165

Article Published Date : Aug 20, 2019

Study Type : Review

Additional Links

Substances : Probiotics

Diseases : Epilepsy

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Additional Keywords : Microbiota

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Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet.May 14, 2020

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Pubmed Data : Rev Neurosci. 2020 May 15. Epub 2020 May 15. PMID: 32406387

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Pubmed Data : Neurol Neurochir Pol. 2011 Jul-Aug;45(4):370-8. PMID: 22101998

Article Published Date : Jun 30, 2011

Study Type : Review

Additional Links

Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

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The ketogenic diet probably creates an unfavorable metabolic environment for cancer cells.Jul 26, 2019

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Pubmed Data : Mol Metab. 2019 Jul 27. Epub 2019 Jul 27. PMID: 31399389

Article Published Date : Jul 26, 2019

Study Type : Review

Additional Links

Diseases : Cancers: All

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Chemotherapeutic

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The results obtained from animal models are encouraging and show that ketogenic diet presents a viable option as an adjunct therapy for cancer.Dec 31, 2015

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Pubmed Data : Recent Results Cancer Res. 2016;207:233-40. PMID: 27557542

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View the Evidence: 116 Abstracts with Dietary Modification: Low Carbohydrate/Ketogenic Research

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Impact of a ketogenic diet on metabolic parameters in patients with obesity or overweight and with or without type 2 diabetes.Jul 05, 2020

The ketone body, beta-hydroxybutyrate, associated with the low-carb diet and fasting may be responsible for the initial euphoria experienced by those undergoing these dietary modifications.Jan 01, 2007

There was an overall tumor growth delaying effect of unrestricted ketogenic diets in mice.Dec 31, 2015

A ketogenic diet could help reduce the frequency of migraine attacks. Dec 31, 2015

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

A ketogenic diet is an effective therapeutic modality for epilepsy associated with tuberous sclerosis in children. Oct 01, 2005

A Ketogenic diet is effective in refractory epilepsy of childhood.Dec 13, 1901

A low-carbohydrate, ketogenic diet improves fatty liver disease. Feb 01, 2007

A low-carbohydrate, ketogenic reduces narcolepsy symptoms.Jun 22, 2004

Beyond seizure control, patients experienced a marked improvement in behavior and awareness. Dec 01, 2019

Both a modified Atkins diet and the classic ketogenic diet could be used in the treatment of intractable epilepsy in children.Dec 09, 2015

Calorically restricted diets could be effective in reducing the anxiety and in improving motor behavior in girls with Rett Syndrome.Jun 01, 2009

Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumorsJan 09, 2017

Effects of very low calorie ketogenic diet on the orexinergic system, visceral adipose tissue, and ROS production.Dec 12, 2019

Ketogenic diet is an important non-pharmacological treatment option for patients with intractable epilepsy associated with tuberous sclerosis complex.May 31, 2017

Ketogenic diet led to rapid weight loss. May 06, 2020

Ketogenic diet treatment as adjuvant to standard treatment of glioblastoma multiforme.Dec 31, 2018

Ketogenic diet-induced weight loss is associated with an increase in vitamin D levels in obese adults.Jul 08, 2019

Ketogenic diets administered as supportive measures during standard therapy are safe and might be helpful in preservation of muscle mass.Dec 31, 2015

Ketogenic, hypocaloric diet improves nonalcoholic steatohepatitis.Feb 29, 2020

Long-term intake of ketogenic diets containing MCTs may additively enhance endurance training–induced increases in ketolytic capacity in skeletal muscle.Apr 29, 2020

Modifiying the diet by increasing fat intake and lowering carbohydrate may have a therapeutic effect in COPD. Mar 01, 2003

People on a ketogenic diet should supplement selenium. Nov 20, 2016

Potassium citrate reduces kidney-stone incidence in children treated with a ketogenic diet for intractable epilepsy. Aug 01, 2009

Short-term physiological effects of a very low-calorie ketogenic diet: effects on adiponectin levels and inflammatory states. May 01, 2020

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

Successful treatment of intractable epilepsy with ketogenic diet therapy in twins with ALG3-CDG.May 06, 2020

Survival outcomes of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy in advanced gastric cancer.Apr 30, 2020

The efficacy of ketogenic diet in 60 Chinese patients with Dravet syndrome.Dec 31, 2018

The ketogenic diet appeared to be an effective therapeutic modality for intractable pediatric epilepsy in tuberous sclerosis complex.Apr 28, 2020

The ketogenic diet could be implemented in medium resources countries and should be included in the management of children with intractable epilepsy.Dec 31, 2018

The ketogenic diet has significant therapy value in treating drug-resistant childhood epilepsy.Sep 01, 2010

The ketogenic diet is a promising therapy for myoclonic status in non-progressive encephalopathy.Jul 10, 2017

The ketogenic diet is an effective therapy for children with therapy-resistant epilepsy.Sep 30, 2015

The ketogenic diet is highly effective and well tolerated in infants with epilepsy.Sep 30, 2015

The ketogenic diet let to a decline in the lactate concentration in tumor tissue.Dec 31, 2012

The ketogenic diet may significantly decrease carbon dioxide body stores, which may theoretically be beneficial for patients with increased carbon dioxide arterial partial pressure.Sep 25, 2015

The ketogenic diet normalized concentrations of the colonic microbiome in patients with multiple sclerosis.Dec 31, 2016

The ketogenic diet regimen is considered to be a promising support therapy for patients with different types of advanced cancer. May 18, 2020

The ketogenic diet seems nutritionally safe and could defer dialysis initiation in some patients with chronic kidney disease.Jan 27, 2016

The ketogenic diet significantly improves quality of life, and reduces both seizures and medication needs in most patients wtih Dravet syndrome studied.Sep 01, 2005

The ketogenic diet was beneficial for patients with GLUT-1 deficiency syndrome.Jan 13, 2016

The long-term effects of a diet loosely restricting carbohydrates results in significantly improved HbA1c levels, blood lipid profiles and reduced drug requirements in type 2 diabetes. Feb 01, 2008

The results show that the ketogenic diet is effective in Lennox-Gastaut syndrome.Nov 30, 2016

These findings suggest that Ketogenic diets may be a safe and achievable component of treatment for some cancer patients.Jul 26, 2019

These results expand our understanding of human adaptation to a ketogenic diet combined with exercise.Sep 27, 2020

Three to 6 years after initiation, the ketogenic diet had proven to be effective in the control of difficult-to-control seizures in children.Sep 30, 2001

Treatment with ketogenic diet resulted in a marked improvement in seizures and cognitive functions.Sep 30, 2015

Treatment with the ketogenic diet reduces the number of emergency department visits in children with refractory epilepsy.Dec 31, 2015

Very-low-calorie ketogenic diet as a safe and valuable tool for long-term glycemic management in patients with obesity and type 2 diabetes.Feb 25, 2021

"Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases."Oct 31, 1992

A combination of high-dose vitamin D3 and ketogenic diet leads to changes in some biological markers of breast cancer.Sep 30, 2015

Autism and Dietary Therapy: Case Report and Review of the Literature.May 09, 2013

Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease: A case study.Mar 31, 2019

Ketogenic diets potentially reverse Type II diabetes and ameliorate clinical depression: A case study.Mar 31, 2019

Management of glioblastoma multiforme in a patient treated with ketogenic metabolic therapy and modified standard of care: a 24-month follow-up.Dec 31, 2017

The ketogenic diet compensates for AGC1 deficiency and improves myelination.Sep 23, 2015

The ketogenic diet could represent an effective treatment to support brain function in selected cases of congenital hyperinsulinism.Dec 31, 2014

This case report suggests that a ketogenic diet may improve hypertrophic cardiomyopathy in the context of mitochondrial disease. Apr 27, 2020

A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms.Jun 06, 2016

A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft.Nov 26, 2019

A ketogenic diet delays weight loss and does not impair working memory or motor function in the mouse model of Huntington's disease.Apr 09, 2011

A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus.Dec 31, 2017

A ketogenic diet in combination with nutritrional supplementation has remarkable therapeutic properties in a rodent model of ALS. Dec 31, 2013

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.Jan 02, 2017

A low carbohydrate ketogenic diet is cardioprotective following global ischemic injury. Aug 01, 2007

A low carbohydrate/ketogenic diet inhibits prostate cancer progression in an animal model. Mar 06, 2012

A novel combination of ketogenic diet, ketone supplementation and hyperbaric oxygen therapy could be used to manage metastatic cancers.Dec 31, 2014

Aberrant mitochondrial morphology and function in the BTBR mouse model of autism is improved by two weeks of ketogenic diet.May 04, 2020

Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model.Dec 31, 2014

Ketogenic and related diets may provide significant relief from the core symptoms of autism spectrum disorders.Dec 31, 2016

Ketogenic diet activates protective γδ T cell responses against influenza virus infection.Nov 14, 2019

Dietary Modification: Low Carbohydrate/Ketogenic

View the Evidence:
116 Abstracts with Dietary Modification: Low Carbohydrate/Ketogenic Research