Dietary Modification: Low Carbohydrate/Ketogenic

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66 Diseases Researched for Dietary Modification: Low Carbohydrate/Ketogenic
NameACCKFocus
Epilepsy: Childhood770Locked
Epilepsy1157Locked
Seizures850Locked
Cancers: All533Locked
Epileptic Seizures321Locked
Autism Spectrum Disorders620Locked
Dravet syndrome220Locked
Lennox-Gastaut Syndrome220Locked
Epilepsy: Infant213Locked
Parkinson's Disease313Locked
Headache: Migraine211Locked
Chronic Kidney Disease (CKD)110Locked
Chronic Obstructive Pulmonary Disease110Locked
Diabetes Mellitus: Type 2110Locked
Diabetes: Glycation/A1C110Locked
Encephalopathy110Locked
Fatty Liver110Locked
Glioblastoma110Locked
Glucose Transporter 1 Deficiency Syndrome110Locked
Head and Neck Cancer110Locked
Hepatic Steatosis110Locked
Infantile Spasms110Locked
Kidney Stones110Locked
Liver: Fatty110Locked
Metabolic Diseases110Locked
Multiple Sclerosis110Locked
Narcolepsy110Locked
Rett Syndrome110Locked
Tuberous Sclerosis110Locked
Amyotrophic lateral sclerosis (ALS)46Locked
Alzheimer's Disease45Locked
Neurologic Disorders35Locked
Brain Cancer44Locked
Glioma34Locked
Aspartate-glutamate carrier (AGC1) Deficiency 13Locked
Autism13Locked
Breast Cancer13Locked
Casein Intolerance13Locked
Congenital Disorders13Locked
Glioblastoma Multiforme13Locked
Gluten Sensitivity13Locked
Hyperinsulinism13Locked
Neurodegenerative Diseases33Locked
Aging12Locked
Autoimmune Diseases12Locked
Brain: Microglial Activation12Locked
Cancer Metastasis12Locked
Cognitive Decline/Dysfunction12Locked
Colon Cancer12Locked
Heart Disease: Ischemic12Locked
Huntington Disease12Locked
Kabuki Make-Up Syndrome12Locked
Multiple Sclerosis: Relapsing-Remitting 12Locked
Oxidative Stress12Locked
Prostate Cancer12Locked
Spinal Cord Injuries12Locked
Amyotrophic Lateral Sclerosis11Locked
Astrocytoma11Locked
Cardiovascular Diseases11Locked
Convulsive Seizures11Locked
Excitotoxicity 11Locked
Hemiplegia11Locked
Mitochondrial Diseases11Locked
Mood Disorders11Locked
Neuroblastoma11Locked
Thyroid Cancer11Locked
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View the Evidence:
81 Abstracts with Dietary Modification: Low Carbohydrate/Ketogenic Research

[+]

The ketone body, beta-hydroxybutyrate, associated with the low-carb diet and fasting may be responsible for the initial euphoria experienced by those undergoing these dietary modifications.Jan 01, 2007

Pubmed Data : Med Hypotheses. 2007;68(2):268-71. Epub 2006 Oct 2. PMID: 17011713
Article Published Date : Jan 01, 2007
Study Type : Meta Analysis
Additional Links
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Fasting/Caloric Restriction
[+]

There was an overall tumor growth delaying effect of unrestricted ketogenic diets in mice.Dec 31, 2015

Pubmed Data : PLoS One. 2016;11(5):e0155050. Epub 2016 May 9. PMID: 27159218
Article Published Date : Dec 31, 2015
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Median Survival Time, Risk Reduction
[+]

A ketogenic diet could help reduce the frequency of migraine attacks. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Headache Pain. 2016 ;17:58. Epub 2016 May 31. PMID: 27245682
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Headache: Migraine
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

Pubmed Data : Przegl Lek. 2010;67(3):205-12. PMID: 20687386
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

A ketogenic diet is an effective therapeutic modality for epilepsy associated with tuberous sclerosis in children. Oct 01, 2005

Pubmed Data : Epilepsia. 2005 Oct;46(10):1684-6. PMID: 16190943
Article Published Date : Oct 01, 2005
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood, Tuberous Sclerosis
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A Ketogenic diet is effective in refractory epilepsy of childhood.Dec 13, 1901

Pubmed Data : Rev Neurol. 2001 Dec 1-15;33(11):1010-4. PMID: 11785025
Study Type : Human Study
Additional Links
Substances : Medium Chain Triglycerides
Diseases : Epilepsy: Childhood
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A low-carbohydrate, ketogenic diet improves fatty liver disease. Feb 01, 2007

Pubmed Data : Dig Dis Sci. 2007 Feb;52(2):589-93. Epub 2007 Jan 12. PMID: 17219068
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Diseases : Fatty Liver, Hepatic Steatosis, Liver: Fatty
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A low-carbohydrate, ketogenic reduces narcolepsy symptoms.Jun 22, 2004

Pubmed Data : Neurology. 2004 Jun 22;62(12):2300-2. PMID: 15210901
Article Published Date : Jun 22, 2004
Study Type : Human Study
Additional Links
Diseases : Narcolepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Both a modified Atkins diet and the classic ketogenic diet could be used in the treatment of intractable epilepsy in children.Dec 09, 2015

Pubmed Data : Epilepsia. 2015 Dec 10. Epub 2015 Dec 10. PMID: 26662710
Article Published Date : Dec 09, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Calorically restricted diets could be effective in reducing the anxiety and in improving motor behavior in girls with Rett Syndrome.Jun 01, 2009

Pubmed Data : Epilepsy Behav. 2009 Jun;15(2):133-41. Epub 2009 Feb 26. PMID: 19249385
Article Published Date : Jun 01, 2009
Study Type : Human Study
Additional Links
Diseases : Autism Spectrum Disorders, Rett Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Fasting/Caloric Restriction
[+]

Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumorsJan 09, 2017

Pubmed Data : J Neurooncol. 2017 Jan 10. Epub 2017 Jan 10. PMID: 28074323
Article Published Date : Jan 09, 2017
Study Type : Human Study
Additional Links
Diseases : Glioblastoma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Ketogenic diet is an important non-pharmacological treatment option for patients with intractable epilepsy associated with tuberous sclerosis complex.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Epilepsy Res. 2017 Jun ;7(1):45-49. Epub 2017 Jun 30. PMID: 28775955
Article Published Date : May 31, 2017
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Ketogenic diets administered as supportive measures during standard therapy are safe and might be helpful in preservation of muscle mass.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Res Notes. 2016 ;9(1):143. Epub 2016 Mar 5. PMID: 26946138
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Integrative Medicine
[+]

Modifiying the diet by increasing fat intake and lowering carbohydrate may have a therapeutic effect in COPD. Mar 01, 2003

Pubmed Data : Nutrition. 2003 Mar;19(3):229-32. PMID: 12620524
Article Published Date : Mar 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chronic Obstructive Pulmonary Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

People on a ketogenic diet should supplement selenium. Nov 20, 2016

Pubmed Data : Biol Trace Elem Res. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27873289
Article Published Date : Nov 20, 2016
Study Type : Human Study
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Potassium citrate reduces kidney-stone incidence in children treated with a ketogenic diet for intractable epilepsy. Aug 01, 2009

Pubmed Data : Pediatrics. 2009 Aug;124(2):e300-4. Epub 2009 Jul 13. PMID: 19596731
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Potassium
Diseases : Epilepsy: Childhood, Kidney Stones
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

Pubmed Data : Pediatr Neurol. 2015 Nov ;53(5):422-6. Epub 2015 Aug 8. PMID: 26476148
Article Published Date : Oct 31, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet could be implemented in medium resources countries and should be included in the management of children with intractable epilepsy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav Case Rep. 2019 ;11:35-38. Epub 2018 Nov 23. PMID: 30619711
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet has significant therapy value in treating drug-resistant childhood epilepsy.Sep 01, 2010

Pubmed Data : Seizure. 2010 Sep;19(7):404-8. Epub 2010 Jul 2. PMID: 20598586
Article Published Date : Sep 01, 2010
Study Type : Human Study
Additional Links
Diseases : Dravet syndrome, Epilepsy: Childhood, Infantile Spasms, Lennox-Gastaut Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet is a promising therapy for myoclonic status in non-progressive encephalopathy.Jul 10, 2017

Pubmed Data : Seizure. 2017 Jul 11 ;51:1-5. Epub 2017 Jul 11. PMID: 28743048
Article Published Date : Jul 10, 2017
Study Type : Human Study
Additional Links
Diseases : Encephalopathy, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : Significant Treatment Outcome
[+]

The ketogenic diet is an effective therapy for children with therapy-resistant epilepsy.Sep 30, 2015

Pubmed Data : Epilepsy Behav. 2015 Oct ;51:261-6. Epub 2015 Aug 24. PMID: 26301622
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet is highly effective and well tolerated in infants with epilepsy.Sep 30, 2015

Pubmed Data : Epilepsy Res. 2015 Oct ;116:53-8. Epub 2015 Jul 9. PMID: 26354167
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Infant, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet let to a decline in the lactate concentration in tumor tissue.Dec 31, 2012

Pubmed Data : Nutr Cancer. 2013 ;65(6):843-9. PMID: 23909728
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Diseases : Head and Neck Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Chemotherapeutic
[+]

The ketogenic diet may significantly decrease carbon dioxide body stores, which may theoretically be beneficial for patients with increased carbon dioxide arterial partial pressure.Sep 25, 2015

Pubmed Data : Lung. 2015 Sep 26. Epub 2015 Sep 26. PMID: 26410589
Article Published Date : Sep 25, 2015
Study Type : Human Study
Additional Links
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet normalized concentrations of the colonic microbiome in patients with multiple sclerosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2017 ;8:1141. Epub 2017 Jun 28. PMID: 28702003
Article Published Date : Dec 31, 2016
Study Type : Human Study
Additional Links
Diseases : Multiple Sclerosis
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Gastrointestinal Agents
Additional Keywords : Microbiome
[+]

The ketogenic diet seems nutritionally safe and could defer dialysis initiation in some patients with chronic kidney disease.Jan 27, 2016

Pubmed Data : J Am Soc Nephrol. 2016 Jan 28. Epub 2016 Jan 28. PMID: 26823552
Article Published Date : Jan 27, 2016
Study Type : Human Study
Additional Links
Diseases : Chronic Kidney Disease (CKD)
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Dietary Modification: Vegetarian
Pharmacological Actions : Renoprotective
Additional Keywords : Risk Reduction
[+]

The ketogenic diet significantly improves quality of life, and reduces both seizures and medication needs in most patients wtih Dravet syndrome studied.Sep 01, 2005

Pubmed Data : Epilepsia. 2005 Sep;46(9):1539-44. PMID: 16146451
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Dravet syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : Drug Sparing
[+]

The ketogenic diet was beneficial for patients with GLUT-1 deficiency syndrome.Jan 13, 2016

Pubmed Data : Seizure. 2016 Jan 14 ;35:83-87. Epub 2016 Jan 14. PMID: 26803281
Article Published Date : Jan 13, 2016
Study Type : Human Study
Additional Links
Diseases : Epilepsy, Metabolic Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The long-term effects of a diet loosely restricting carbohydrates results in significantly improved HbA1c levels, blood lipid profiles and reduced drug requirements in type 2 diabetes. Feb 01, 2008

Pubmed Data : Diabetes Res Clin Pract. 2008 Feb;79(2):350-6. Epub 2007 Nov 5. PMID: 17980451
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Diseases : Diabetes: Glycation/A1C, Diabetes Mellitus: Type 2
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The results show that the ketogenic diet is effective in Lennox-Gastaut syndrome.Nov 30, 2016

Pubmed Data : Epilepsy Res. 2016 Dec ;128:176-180. Epub 2016 Nov 9. PMID: 27846468
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Diseases : Epilepsy, Lennox-Gastaut Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Three to 6 years after initiation, the ketogenic diet had proven to be effective in the control of difficult-to-control seizures in children.Sep 30, 2001

Pubmed Data : Pediatrics. 2001 Oct ;108(4):898-905. PMID: 11581442
Article Published Date : Sep 30, 2001
Study Type : Human Study
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Treatment with ketogenic diet resulted in a marked improvement in seizures and cognitive functions.Sep 30, 2015

Pubmed Data : Neuropediatrics. 2015 Oct ;46(5):313-20. Epub 2015 Aug 12. PMID: 26267703
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Glucose Transporter 1 Deficiency Syndrome, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Treatment with the ketogenic diet reduces the number of emergency department visits in children with refractory epilepsy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Res Treat. 2016 ;2016:5873208. Epub 2016 Sep 26. PMID: 27752367
Article Published Date : Dec 31, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Risk Reduction
[+]

"Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases."Oct 31, 1992

Pubmed Data : Epilepsia. 1992 Nov-Dec;33(6):1132-6. PMID: 1464275
Article Published Date : Oct 31, 1992
Study Type : Human: Case Report
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A combination of high-dose vitamin D3 and ketogenic diet leads to changes in some biological markers of breast cancer.Sep 30, 2015

Pubmed Data : Anticancer Res. 2015 Oct ;35(10):5525-32. PMID: 26408720
Article Published Date : Sep 30, 2015
Study Type : Human: Case Report
Additional Links
Substances : Vitamin D
Diseases : Breast Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Supplementation
[+]

Autism and Dietary Therapy: Case Report and Review of the Literature.May 09, 2013

Pubmed Data : J Child Neurol. 2013 May 10. Epub 2013 May 10. PMID: 23666039
Article Published Date : May 09, 2013
Study Type : Human: Case Report
Additional Links
Substances : Medium Chain Triglycerides
Diseases : Autism, Autism Spectrum Disorders, Casein Intolerance, Gluten Sensitivity
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Dietary Modification: Wheat/Gluten Free
Problem Substances : Casein, Wheat
[+]

Management of glioblastoma multiforme in a patient treated with ketogenic metabolic therapy and modified standard of care: a 24-month follow-up.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2018 ;5:20. Epub 2018 Mar 29. PMID: 29651419
Article Published Date : Dec 31, 2017
Study Type : Human: Case Report
Additional Links
Substances : Vitamin D
Diseases : Glioblastoma Multiforme
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet compensates for AGC1 deficiency and improves myelination.Sep 23, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsia. 2015 Sep 24. Epub 2015 Sep 24. PMID: 26401995
Article Published Date : Sep 23, 2015
Study Type : Human: Case Report
Additional Links
Diseases : Aspartate-glutamate carrier (AGC1) Deficiency , Epilepsy: Infant, Neurologic Disorders, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Significant Treatment Outcome
[+]

The ketogenic diet could represent an effective treatment to support brain function in selected cases of congenital hyperinsulinism.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Orphanet J Rare Dis. 2015 ;10(1):120. Epub 2015 Sep 24. PMID: 26399329
Article Published Date : Dec 31, 2014
Study Type : Human: Case Report
Additional Links
Diseases : Congenital Disorders, Hyperinsulinism, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Significant Treatment Outcome
[+]

A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms.Jun 06, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Rep. 2016 Jun 7 ;15(10):2136-46. Epub 2016 May 26. PMID: 27239035
Article Published Date : Jun 06, 2016
Study Type : Animal Study
Additional Links
Diseases : Autoimmune Diseases, Multiple Sclerosis: Relapsing-Remitting
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Fasting/Caloric Restriction
Additional Keywords : Dietary Modification
[+]

A ketogenic diet delays weight loss and does not impair working memory or motor function in the mouse model of Huntington's disease.Apr 09, 2011

Pubmed Data : Physiol Behav. 2011 Apr 9;103(5):501-507. Epub 2011 Apr 9. PMID: 21501628
Article Published Date : Apr 09, 2011
Study Type : Animal Study
Additional Links
Diseases : Huntington Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Aging Neurosci. 2018 ;10:391. Epub 2018 Dec 3. PMID: 30559660
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Diseases : Aging, Cognitive Decline/Dysfunction
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

A ketogenic diet in combination with nutritrional supplementation has remarkable therapeutic properties in a rodent model of ALS. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e103526. Epub 2014 Jul 25. PMID: 25061944
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Arginine-alpha-ketoglutarate (AAKG), Coenzyme Q10, GABA (gamma-Aminobutyric Acid), Medium Chain Triglycerides
Diseases : Amyotrophic lateral sclerosis (ALS)
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.Jan 02, 2017

Pubmed Data : Proc Natl Acad Sci U S A. 2017 Jan 3 ;114(1):125-130. Epub 2016 Dec 20. PMID: 27999180
Article Published Date : Jan 02, 2017
Study Type : Animal Study
Additional Links
Diseases : Kabuki Make-Up Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

A low carbohydrate ketogenic diet is cardioprotective following global ischemic injury. Aug 01, 2007

Pubmed Data : Acta Cardiol. 2007 Aug;62(4):381-9. PMID: 17824299
Article Published Date : Aug 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Heart Disease: Ischemic
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A low carbohydrate/ketogenic diet inhibits prostate cancer progression in an animal model. Mar 06, 2012

Pubmed Data : BJU Int. 2012 Mar 6. Epub 2012 Mar 6. PMID: 22394625
Article Published Date : Mar 06, 2012
Study Type : Transgenic Animal Study
Additional Links
Diseases : Prostate Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A novel combination of ketogenic diet, ketone supplementation and hyperbaric oxygen therapy could be used to manage metastatic cancers.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(6):e0127407. Epub 2015 Jun 10. PMID: 26061868
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Ketone Bodies
Diseases : Cancer Metastasis
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Hyperbaric Treatment, Integrative Medicine
Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemotherapeutic
[+]

Application of an unrestricted ketogenic diet delayed tumor growth in a mouse xenograft model.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(5):2061-8. PMID: 25773851
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Colon Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Antiproliferative
[+]

Ketogenic and related diets may provide significant relief from the core symptoms of autism spectrum disorders.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Behav. 2017 Jan 1 ;168:138-145. Epub 2016 Nov 9. PMID: 27836684
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Autism Spectrum Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Ketogenic diet therapy might be uniquely suited to reset the epileptogenic clock and to provide long-lasting relief from seizures even after discontinuation of the diet.Aug 05, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropharmacology. 2015 Aug 6 ;99:500-509. Epub 2015 Aug 6. PMID: 26256422
Article Published Date : Aug 05, 2015
Study Type : Animal Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : DNA Methylation, Epigenetic Modification
[+]

Ketogenic metabolism inhibits histone deacetylase and reduces oxidative stress after spinal cord injury.Dec 15, 2017

Pubmed Data : Neuroscience. 2017 Dec 16 ;366:36-43. Epub 2017 Oct 9. PMID: 29024787
Article Published Date : Dec 15, 2017
Study Type : Animal Study
Additional Links
Diseases : Spinal Cord Injuries
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Malondialdehyde Down-regulation, Neuroprotective Agents
[+]

The ketogenic diet may work as an immune adjuvant in the glioma microenvironment by reducing immune suppression.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Cancer. 2016 ;16:310. Epub 2016 May 13. PMID: 27178315
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Immunomodulatory, Immunostimulatory
[+]

The ketogenic diet was neuroprotective and anti-inflammatory against MPTP-neurotoxicity.Sep 30, 2010

Pubmed Data : J Mol Neurosci. 2010 Oct ;42(2):145-53. Epub 2010 Mar 24. PMID: 20333481
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Brain: Microglial Activation, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

These findings may explain, in part, the ability of a KD to mitigate some of the neurological symptoms associated with ASD.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Autism. 2016 ;7(1):37. Epub 2016 Sep 1. PMID: 27594980
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Autism Spectrum Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Microbiota
[+]

This data indicates that skeletal muscle mitochondrial coupling of complex II substrates is more efficient in chronically resistance trained rodents fed a KD.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2016 ;7:533. Epub 2016 Nov 8. PMID: 27877138
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Exercise: Resistance Training
[+]

This study demonstrates the clear benefits of ketogenic diet in the maternal immune activation model of autism spectrum disorder.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(2):e0171643. Epub 2017 Feb 6. PMID: 28166277
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Autism Spectrum Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

"The ketogenic diet: mechanism of anticonvulsant action."Dec 31, 1979

Pubmed Data : Adv Neurol. 1980 ;27:635-42. PMID: 6990715
Article Published Date : Dec 31, 1979
Study Type : Review
Additional Links
Diseases : Convulsive Seizures, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A high fat/low carbohydrate ketogenic diet is therapeutic in an animal model of brain cancer. Feb 21, 2007

Pubmed Data : Nutr Metab (Lond). 2007 Feb 21;4:5. PMID: 17313687
Article Published Date : Feb 21, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Astrocytoma, Brain Cancer, Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A keto-mediet approach with coconut substitution and exercise may delay the onset of Alzheimer's disease.Dec 31, 2016

Pubmed Data : J Prev Alzheimers Dis. 2017 ;4(1):51-57. PMID: 29188860
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Coconut
Diseases : Alzheimer's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic, Exercise
Pharmacological Actions : Neuroprotective Agents
[+]

A ketogenic diet may suppress neuronal hyperexcitability in patients with epilepsy. Dec 01, 2009

Pubmed Data : Mol Nutr Food Res. 2009 Dec;53(12):1603-11. PMID: 16059506
Article Published Date : Dec 01, 2009
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

A review of ketogenic diets in the treatment of epilepsy.Aug 08, 2017

Pubmed Data : Curr Pharm Des. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28799513
Article Published Date : Aug 08, 2017
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A review of the association between diet and mood.Dec 03, 2018

Pubmed Data : Psychiatry Res. 2018 Dec 4 ;271:428-437. Epub 2018 Dec 4. PMID: 30537665
Article Published Date : Dec 03, 2018
Study Type : Review
Additional Links
Diseases : Mood Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

An overview of the Ketogenic diet and childhood neurological disorders other than epilepsy.Nov 20, 2016

Pubmed Data : Expert Rev Neurother. 2016 Nov 21:1-13. Epub 2016 Nov 21. PMID: 27841033
Article Published Date : Nov 20, 2016
Study Type : Review
Additional Links
Diseases : Autism Spectrum Disorders, Headache: Migraine, Hemiplegia, Neurologic Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Calorically restricted ketogenic diets may provide an alternative therapy to brain cancer. Nov 01, 2008

Pubmed Data : Epilepsia. 2008 Nov;49 Suppl 8:114-6. PMID: 19049606
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Brain Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Deuterium depletion in water offers a new adjuvant and protective cancer therapy.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Hypotheses. 2016 Feb ;87:69-74. Epub 2015 Nov 26. PMID: 26826644
Article Published Date : Jan 31, 2016
Study Type : Commentary
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Chemotherapeutic
[+]

Dietary manipulation through the elimination of glucose and/or a ketogenic diet may be therapeutic in the treatment of brain ccancer. Jan 01, 2009

Pubmed Data : J Pediatr Surg. 2009 Jan;44(1):212-6; discussion 216. PMID: 19159745
Article Published Date : Jan 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Brain Cancer, Neuroblastoma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

High-fat and ketogenic diets may have value in treating amyotrophic lateral sclerosis.Jul 31, 2013

Pubmed Data : J Child Neurol. 2013 Aug ;28(8):989-92. Epub 2013 May 10. PMID: 23666040
Article Published Date : Jul 31, 2013
Study Type : Review
Additional Links
Diseases : Amyotrophic Lateral Sclerosis
Therapeutic Actions : Dietary Modification: High-Fat/Low-Carbohydrate , Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Metabolic therapy: a new paradigm for managing malignant brain cancer.Jan 27, 2015

Pubmed Data : Cancer Lett. 2015 Jan 28 ;356(2 Pt A):289-300. Epub 2014 Jul 25. PMID: 25069036
Article Published Date : Jan 27, 2015
Study Type : Review
Additional Links
Diseases : Brain Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

Overview of studies using ketogenic diets to treat various neurological disorders.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2012 ;3:59. Epub 2012 Apr 9. PMID: 22509165
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Diseases : Neurologic Disorders
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

The emerging data provide strong support for the use of a ketogenic diet in the treatment of malignant gliomas.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Neurosci. 2016 ;9:122. Epub 2016 Nov 16. PMID: 27899882
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Angiogenesis Inhibitors, Chemosensitizer, Radiosensitizer
[+]

The ketogenic diet and vitamin C have a potential role in the management of advanced differentiated thyroid cancer.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2017 ;7:160. Epub 2017 Jul 25. PMID: 28791253
Article Published Date : Dec 31, 2016
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Thyroid Cancer
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Chemotherapeutic
[+]

The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease.Oct 09, 2018

Pubmed Data : Nutrition. 2018 Oct 10 ;60:118-121. Epub 2018 Oct 10. PMID: 30554068
Article Published Date : Oct 09, 2018
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Neuroprotective Agents
[+]

The ketogenic diet leads to increases in circulating ketones, which may contribute to the efficacy in treating pharmacoresistant seizures.Jan 21, 2016

Pubmed Data : Cold Spring Harb Perspect Med. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801895
Article Published Date : Jan 21, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet may alter brain handling of glutamate, an excitotoxin, through enhanced conversion to glutamine and then to GABA. Nov 01, 2008

Pubmed Data : Epilepsia. 2008 Nov;49 Suppl 8:73-5. PMID: 19049594
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Excitotoxicity
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet may have therapeutic value in neuromuscular and neurodegenerative Diseases.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2014 ;2014:474296. Epub 2014 Jul 3. PMID: 25101284
Article Published Date : Dec 31, 2013
Study Type : Review
Additional Links
Diseases : Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Mitochondrial Diseases, Neurodegenerative Diseases, Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The ketogenic diet may have value in ALS. Jun 30, 2011

Pubmed Data : Neurol Neurochir Pol. 2011 Jul-Aug;45(4):370-8. PMID: 22101998
Article Published Date : Jun 30, 2011
Study Type : Review
Additional Links
Diseases : Amyotrophic lateral sclerosis (ALS), Neurodegenerative Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

The results obtained from animal models are encouraging and show that ketogenic diet presents a viable option as an adjunct therapy for cancer.Dec 31, 2015

Pubmed Data : Recent Results Cancer Res. 2016;207:233-40. PMID: 27557542
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Diseases : Cancers: All
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Cancers: All, Dietary Modification: Low Carbohydrate/Ketogenic, high fat diet, ketogenic diet
[+]

The scientific literature involving the ketogenic diet strongly supports the notion that epilepsy may indeed in part represent a metabolic disease.Jul 25, 2015

Pubmed Data : Neurosci Lett. 2015 Jul 26. Epub 2015 Jul 26. PMID: 26222258
Article Published Date : Jul 25, 2015
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
[+]

This proposes the use of the ketogenic diet as an effective and efficient preliminary and long-term treatment.Sep 27, 2016

Pubmed Data : Amino Acids. 2016 Sep 28. Epub 2016 Sep 28. PMID: 27683025
Article Published Date : Sep 27, 2016
Study Type : Review
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

This review summarizes the history of the KD and the principles and efficacy of the classic ketogenic diet.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arq Neuropsiquiatr. 2016 Oct ;74(10):842-848. PMID: 27759811
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

This reviews the potential epigenetic processes that may link lifespan to age-related diseases, particularly in the context of ketogenic diets.Nov 20, 2016

Pubmed Data : Mol Cell Endocrinol. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27884781
Article Published Date : Nov 20, 2016
Study Type : Review
Additional Links
Diseases : Cancers: All, Cardiovascular Diseases, Neurodegenerative Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Additional Keywords : Epigenetic Modification

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Since the early 1980’s the USDA Dietary Guidelines have urged Americans to eat a low-fat high-carbohydrate diet for their health and weight control. Since then, there has been an alarming increase in obesity, cancer and diabetes. Could the dietary guidelines be to blame?
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Our scientific dogma says that the latest research is the closest to the truth; yet as soon as new research comes out, it will be obsolete. This paradigm always ignores context. For example, for the past 15 years it has become assumed truth that a low fat diet is a healthy diet. The same people who thirty years ago used to urge us to eat plenty of meat and cheese, shifted to encourage us towards vegetables and low fat salad dressings.

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