Artificial Sweeteners

Name	AC	CK
Diabetes Mellitus: Type 2	7	82
Insulin Resistance	7	69
Dysbiosis	5	60
Diabetes Mellitus: Type 2: Prevention	3	51
Metabolic Syndrome X	2	50
Urinary Tract Cancer	1	40
Kidney Diseases	2	21
Allergy: Cow's Milk	1	20
Diabetes: Kidney Function	1	20
Fibromyalgia	2	20
Kidney Damage	1	20
Kidney Failure	1	20
Phenylketonurias	1	20
Inflammation	4	18
Obesity	6	17
Prenatal Chemical Exposures	4	16
Excitotoxicity	3	13
Acidosis	1	12
Chemically-Induced Liver Damage	5	12
Metabolic Acidosis	1	12
Brain Cancer	2	11
DNA damage	4	11
Cardiovascular Diseases	1	10
HIV Infections	1	10
Lipid Peroxidation	5	10
Multiple Myeloma	1	10
Non-Hodgkin Lymphoma	1	10
Obesity: Childhood	1	10
Leukemia	5	9
Hyperinsulinism	3	8
Overweight	3	8
Oxidative Stress	4	8
Metabolic Diseases	3	7
Brain: Oxidative Stress	3	6
Cancers: All	3	6
Crohn's Disease	3	6
Hyperglycemia	3	6
Lymphoma	3	6
Aging	1	4
Appetite Disorders	1	4
Atherosclerosis	1	4
Circadian Dysregulation	1	4
Colon Cancer	1	4
Dental Caries	1	4
Fatty Liver	1	4
Dermatitis	1	3
Formaldehyde Toxicity	1	3
Hematologic Diseases	2	3
Vaccine-induced Toxicity	1	3
ALT: Elevated	1	2
AST: Elevated	1	2
Abdominal Obesity (Midsection Fat)	1	2
Alzheimer's Disease	1	2
Bladder Cancer	1	2
Brain Inflammation	1	2
Brain: Vascular Congestion	1	2
Cognitive Decline/Dysfunction	1	2
Diabetes	1	2
Eating Disorders	1	2
Fetal Origin of Adult Disease	1	2
HPA Axis Dysregulation	1	2
Hyperlipidemia	1	2
Hypothyroidism	1	2
Immune Disorders: Low Immune Function	1	2
Infertility: Male	1	2
Inflammatory Bowel Diseases	2	2
Insulin: Elevated	1	2
Liver Cancer	1	2
Lung Cancer	1	2
Migraine Disorders	2	2
Neurologic Disorders	1	2
Parkinson's Disease	1	2
Placental Insufficiency	1	2
Prediabetes	1	2
Pregnancy Complications	1	2
Renal Cancer	1	2
Schwannoma	1	2
Attention Deficit Disorder with Hyperactivity	1	1
Cervical Cancer	1	1
Clostridium Enterocolitis	1	1
Emotional Disorders	1	1
Glioma	1	1
High Sugar Diet	1	1
Learning disorders	1	1
Medulloblastoma	1	1
Meningioma	1	1
Mental Disorders	1	1
Neurodevelopmental Disorders	1	1
Ulcerative Colitis	1	1

Name	AC	CK
Neurotoxic	14	28
Nephrotoxic	1	20
Carcinogenic	6	19
Endocrine Disruptor: Insulin Resistance	3	14
Hepatotoxic	4	11
Irritant	1	10
Oxidant	4	8
Diabetogenic	3	6
Obesogenic	2	6
Endocrine Disruptor: Thyroid	1	2
Gastrotoxic	1	2
Genotoxic	1	2
Glutathione Down-Regulation	1	2
Immunoreactive	1	2
Inflammatory	2	2
Renotoxic	1	1

Click here to read the entire abstract

Pubmed Data : Am J Clin Nutr. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28228424

Article Published Date : Feb 21, 2017

Study Type : Human Study

Additional Links

Problem Substances : Sucralose (aka Splenda)

[+]

Non-nutritive sweeteners consumption during pregnancy and lactation may have adverse effects on infant metabolism.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Microbiol. 2019 ;10:1360. Epub 2019 Jun 20. PMID: 31281295

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524

Click here to read the entire abstract

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989

Article Published Date : Jun 01, 2001

Study Type : Human Study

Additional Links

Diseases : Excitotoxicity , Fibromyalgia

Problem Substances : Aspartame, Monosodium Glutamate (MSG)

[+]

These findings illustrated positive associations between intrauterine exposure to artificially sweetened beverage and risk of obesity at 7 years.Jun 05, 2017

Click here to read the entire abstract

Pubmed Data : Int J Epidemiol. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28586472

Article Published Date : Jun 05, 2017

Study Type : Human Study

Additional Links

Diseases : Obesity: Childhood

Additional Keywords : Risk Factors, Transgenerational Epigenetic Modification

Problem Substances : Artificial Sweeteners

[+]

This data suggests that aspartame may contribute to cardiovascular disease risk in HIV.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Endocrinol Nutr. 2015 Mar ;62(3):114-22. Epub 2015 Feb 11. PMID: 25681123

Article Published Date : Feb 28, 2015

Study Type : Animal Study

Additional Links

Diseases : Lipid Peroxidation

Additional Keywords : Cytokines

Problem Substances : Aspartame

Adverse Pharmacological Actions : Immunoreactive, Oxidant

[+]

Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.Sep 30, 2010

Click here to read the entire abstract

Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530

Click here to read the entire abstract

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243

Article Published Date : Jan 01, 2012

Study Type : Animal Study

Additional Links

Diseases : Cognitive Decline/Dysfunction, Insulin Resistance

Problem Substances : Aspartame

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Neurotoxic

[+]

Aspartame consumption may constitute a hazard because of its contribution to the formation of formaldehyde adducts.Jan 01, 1998

Pubmed Data : PLoS One. 2014 ;9(10):e109841. Epub 2014 Oct 14. PMID: 25313461

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Diseases : Metabolic Diseases, Obesity

Additional Keywords : Increased Risk, Microbiota

Problem Substances : Aspartame

[+]

Aspartame is associated with neurological dysfunction. Dec 01, 2007

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Problem Substances : Aspartame

[+]

Aspartame may induce redox and lipid imbalance in rats via mechanism that involves oxidative stress and depletion of glutathione-dependent system.Aug 05, 2015

Click here to read the entire abstract

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247507

Article Published Date : Aug 05, 2015

Study Type : Animal Study

Additional Links

Diseases : Lipid Peroxidation

Problem Substances : Aspartame

Adverse Pharmacological Actions : Oxidant

[+]

Aspartame produces methanol as a metabolite, which can be converted into the cytotoxic chemicals formaledhyde and formate. Jan 01, 2002

Click here to read the entire abstract

Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085

Article Published Date : Jan 01, 2002

Study Type : Animal Study

Additional Links

Problem Substances : Aspartame, Formaldehyde, Formate

[+]

Aspartames break down product phenylalanine, can inhibit the protective effects of intestinal alkaline phosphatase.Nov 17, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Appl Physiol Nutr Metab. 2016 Nov 18:1-7. Epub 2016 Nov 18. PMID: 27997218

Article Published Date : Nov 17, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 16:e22053. Epub 2018 Apr 16. PMID: 29660801

Article Published Date : Apr 15, 2018

Study Type : Animal Study

Additional Links

Problem Substances : Artificial Sweeteners

Adverse Pharmacological Actions : Neurotoxic

[+]

Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Dec 31, 1969

Click here to read the entire abstract

Study Type : Animal Study

Additional Links

Diseases : Abdominal Obesity (Midsection Fat), Diabetes, Obesity, Overweight

Problem Substances : Aspartame, Monosodium Glutamate (MSG)

Adverse Pharmacological Actions : Diabetogenic, Obesogenic

[+]

Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice.Jun 18, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Metab (Lond). 2013 Jun 19 ;10(1):44. Epub 2013 Jun 19. PMID: 23783067

Article Published Date : Jun 18, 2013

Study Type : Transgenic Animal Study

Additional Links

Diseases : Prediabetes

Problem Substances : Aspartame, Monosodium Glutamate (MSG), Trans Fatty Acids

Adverse Pharmacological Actions : Diabetogenic

[+]

Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult rats, at similar total caloric intake levels.Oct 18, 2012

Pubmed Data : PLoS One. 2014 ;9(4):e92771. Epub 2014 Apr 3. PMID: 24699280

Article Published Date : Dec 31, 2013

Study Type : Insect Study

Additional Links

Diseases : Lipid Peroxidation

Additional Keywords : Lipid Peroxidation, Splenda, Sucralose

Problem Substances : Sucralose (aka Splenda)

Adverse Pharmacological Actions : Neurotoxic

[+]

Sucralose inhibits thyroid function and metabolism in doses within the range of the human acceptable daily intake. Dec 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879

Article Published Date : Dec 30, 2016

Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291

Article Published Date : Jan 01, 2008

Study Type : Animal Study

Additional Links

Problem Substances : Sucralose (aka Splenda)

[+]

The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in mice.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2017 ;12(6):e0178426. Epub 2017 Jun 8. PMID: 28594855

Pubmed Data : Food Chem Toxicol. 1997 Dec;35(12):1177-9. PMID: 9449223

Article Published Date : Dec 01, 1997

Study Type : In Vitro Study

Additional Links

Problem Substances : Acesulfame potassium

[+]

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.Mar 01, 2006

Click here to read the entire abstract

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620

Article Published Date : Mar 01, 2006

Study Type : In Vitro Study

Additional Links

Diseases : Attention Deficit Disorder with Hyperactivity, Excitotoxicity , Neurodevelopmental Disorders

Additional Keywords : Drug-Plant-Vitamin Synergies

Problem Substances : Aspartame, Brilliant Blue FCF, L-glutamic Acid, Quinoline Yellow

Adverse Pharmacological Actions : Neurotoxic

[+]

Aspartame contains 11% methanol by weight, which converts to formaldehyde in organs other than the liver. Mar 01, 2010

Click here to read the entire abstract

Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282

Article Published Date : Mar 01, 2010

Study Type : Commentary

Additional Links

Problem Substances : Aspartame

[+]

[+]

Problem Substances : Aspartame

Adverse Pharmacological Actions : Hepatotoxic, Renotoxic

[+]

[+]

Click here to read the entire abstract

Pubmed Data : Folia Neuropathol. 2013 ;51(1):10-7. PMID: 23553132

Article Published Date : Dec 31, 2012

Study Type : Review

Additional Links

Diseases : Brain Cancer, Glioma, Medulloblastoma, Meningioma

Problem Substances : Aspartame

Adverse Pharmacological Actions : Carcinogenic

[+]

Various food additives, preservatives, fungicides and artificial sweeteners have been demonstrated to have the potential to damage DNA in gastrointestinal organs. Aug 26, 2002

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896

Article Published Date : Aug 26, 2002

Study Type : In Vitro Study

Additional Links

Diseases : DNA damage

Problem Substances : Biphenyl, Butylated hydroxyanisole (BHA), Butylated Hydroxytoluene (BHT), Saccharin, Sodium Cyclamate, Sodium o-phenylphenol, Sucralose (aka Splenda), Thiabendazole

Artificial Sweeteners jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

The Following are Sub-Topics of Artificial Sweeteners

FREE Member Preview Enabled

View the Evidence: 128 Abstracts with Artificial Sweeteners Research

Limited to Members Only

Currently Available Sorting Options

Acesulfame-potassium and sucralose transfer into breast milk following ingestion of a diet soda.Feb 28, 2018

Artificial sweetener consumption is associated with urinary tract tumors. Jul 01, 2008