Artificial Sweeteners

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89 Diseases Researched for Artificial Sweeteners
NameACCKFocus
Diabetes Mellitus: Type 2782Locked
Insulin Resistance769Locked
Dysbiosis560Locked
Diabetes Mellitus: Type 2: Prevention351Locked
Metabolic Syndrome X250Locked
Urinary Tract Cancer140Locked
Kidney Diseases221Locked
Allergy: Cow's Milk 120Locked
Diabetes: Kidney Function 120Locked
Fibromyalgia220Locked
Kidney Damage120Locked
Kidney Failure120Locked
Phenylketonurias120Locked
Inflammation418Locked
Obesity617Locked
Prenatal Chemical Exposures416Locked
Excitotoxicity 313Locked
Acidosis112Locked
Chemically-Induced Liver Damage512Locked
Metabolic Acidosis112Locked
Brain Cancer211Locked
DNA damage411Locked
Cardiovascular Diseases110Locked
HIV Infections110Locked
Lipid Peroxidation510Locked
Multiple Myeloma110Locked
Non-Hodgkin Lymphoma110Locked
Obesity: Childhood110Locked
Leukemia59Locked
Hyperinsulinism38Locked
Overweight 38Locked
Oxidative Stress48Locked
Metabolic Diseases37Locked
Brain: Oxidative Stress36Locked
Cancers: All36Locked
Crohn's Disease36Locked
Hyperglycemia36Locked
Lymphoma36Locked
Aging14Locked
Appetite Disorders14Locked
Atherosclerosis14Locked
Circadian Dysregulation14Locked
Colon Cancer14Locked
Dental Caries14Locked
Fatty Liver14Locked
Dermatitis13Locked
Formaldehyde Toxicity13Locked
Hematologic Diseases23Locked
Vaccine-induced Toxicity 13Locked
ALT: Elevated12Locked
AST: Elevated12Locked
Abdominal Obesity (Midsection Fat)12Locked
Alzheimer's Disease12Locked
Bladder Cancer12Locked
Brain Inflammation 12Locked
Brain: Vascular Congestion12Locked
Cognitive Decline/Dysfunction12Locked
Diabetes12Locked
Eating Disorders12Locked
Fetal Origin of Adult Disease12Locked
HPA Axis Dysregulation12Locked
Hyperlipidemia12Locked
Hypothyroidism12Locked
Immune Disorders: Low Immune Function12Locked
Infertility: Male12Locked
Inflammatory Bowel Diseases22Locked
Insulin: Elevated12Locked
Liver Cancer12Locked
Lung Cancer12Locked
Migraine Disorders22Locked
Neurologic Disorders12Locked
Parkinson's Disease12Locked
Placental Insufficiency12Locked
Prediabetes12Locked
Pregnancy Complications12Locked
Renal Cancer12Locked
Schwannoma12Locked
Attention Deficit Disorder with Hyperactivity11Locked
Cervical Cancer11Locked
Clostridium Enterocolitis11Locked
Emotional Disorders11Locked
Glioma11Locked
High Sugar Diet11Locked
Learning disorders11Locked
Medulloblastoma11Locked
Meningioma11Locked
Mental Disorders11Locked
Neurodevelopmental Disorders11Locked
Ulcerative Colitis11Locked
16 Adverse Pharmacological Actions Researched for Artificial Sweeteners
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View the Evidence:
157 Abstracts with Artificial Sweeteners Research

[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Oct 22 ;23(21). Epub 2022 Oct 22. PMID: 36361530
Study Type : Animal Study, Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : J Pediatr Gastroenterol Nutr. 2018 Mar ;66(3):466-470. PMID: 29077645
Study Type : Human Study
Additional Links
Additional Keywords : Breast Feeding, Microbiome, Risk Factors
[+]
Pubmed Data : Prev Med. 2008 Jul;47(1):136-9. Epub 2008 Apr 8. PMID: 18495230
Study Type : Human Study
Additional Links
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ. 2022 Sep 7 ;378:e071204. Epub 2022 Sep 7. PMID: 36638072
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
Adverse Pharmacological Actions : Cardiotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Care. 2023 Sep 1 ;46(9):1681-1690. PMID: 37490630
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : Nature. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25231862
Study Type : Animal Study, Human Study
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ISME J. 2022 Feb ;16(2):543-554. Epub 2021 Sep 1. PMID: 34465899
Study Type : Human Study
Additional Links
Additional Keywords : Horizontal Gene Transfer
Problem Substances : Artificial Sweeteners
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Med. 2022 Mar ;19(3):e1003950. Epub 2022 Mar 24. PMID: 35324894
Study Type : Human Study
Additional Links
Diseases : Cancers: All
Additional Keywords : Increased Risk
[+]
Pubmed Data : J Neuropathol Exp Neurol. 1996 Nov;55(11):1115-23. PMID: 8939194
Study Type : Human Study
Additional Links
Diseases : Brain Cancer
Problem Substances : Aspartame
[+]
Pubmed Data : Ann Nutr Metab. 2017 Feb 18 ;70(1):51-58. Epub 2017 Feb 18. PMID: 28214853
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners
[+]
Pubmed Data : Clin J Am Soc Nephrol. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20884773
Study Type : Human Study
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Aug 29 ;15(17). Epub 2023 Aug 29. PMID: 37686804
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Family Med Prim Care. 2020 Jan ;9(1):69-71. Epub 2020 Jan 28. PMID: 32110567
Study Type : Human Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Artificial Sweeteners
[+]
Pubmed Data : Am J Clin Nutr. 2017 Jan ;105(1):144-150. Epub 2016 Nov 23. PMID: 27881392
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267
Study Type : Human Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]
Pubmed Data : Am J Clin Nutr. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28228424
Study Type : Human Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2019 ;10:1360. Epub 2019 Jun 20. PMID: 31281295
Study Type : Human Study
Additional Links
Problem Substances : Artificial Sweeteners
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Obes (Lond). 2023 Jul 13. Epub 2023 Jul 13. PMID: 37443272
Study Type : Human Study
Additional Links
Diseases : Obesity
Problem Substances : Aspartame, Saccharin
[+]
Pubmed Data : J Toxicol Environ Health A. 2015 ;78(16):1029-32. Epub 2015 Aug 12. PMID: 26267522
Study Type : Human Study
[+]
Pubmed Data : Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. PMID: 16679819
Study Type : Human Study
Additional Links
Problem Substances : Sodium Cyclamate
Adverse Pharmacological Actions : Irritant
[+]
Pubmed Data : Diabetes Care. 2013 Apr 30. Epub 2013 Apr 30. PMID: 23633524
Study Type : Human Study
[+]
Pubmed Data : Nat Med. 2023 Mar ;29(3):710-718. Epub 2023 Feb 27. PMID: 36849732
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
Adverse Pharmacological Actions : Cardiotoxic
[+]
Pubmed Data : Diabetes Care. 2009 Apr;32(4):688-94. Epub 2009 Jan 16. PMID: 19151203
Study Type : Human Study
[+]
Pubmed Data : Clin Exp Rheumatol. 2012 Jul 4. Epub 2012 Jul 4. PMID: 22766026
Study Type : Human Study
[+]
Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Study Type : Human Study
Additional Links
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Nov 24 ;14(23). Epub 2022 Nov 24. PMID: 36501030
Study Type : Human Study
Additional Links
Problem Substances : Aspartame, Sucralose (aka Splenda)
[+]
Pubmed Data : Int J Epidemiol. 2017 Jun 6. Epub 2017 Jun 6. PMID: 28586472
Study Type : Human Study
Additional Links
Problem Substances : Artificial Sweeteners
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Forum Infect Dis. 2017 ;4(2):ofx083. Epub 2017 Apr 24. PMID: 28695142
Study Type : Human Study
[+]
Pubmed Data : Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016 Sep 9. Epub 2016 Sep 9. PMID: 27612000
Study Type : Human Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners, Aspartame
[+]
Pubmed Data : J Nutr Biochem. 2023 Mar ;113:109228. Epub 2022 Nov 23. PMID: 36435291
Study Type : Animal Study, In Vitro Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Eur J Pediatr. 2012 Mar 30. Epub 2012 Mar 30. PMID: 22457081
Study Type : Human: Case Report
[+]
Pubmed Data : J Cutan Med Surg. 2015 Sep-Oct;19(5):504-6. Epub 2015 Apr 15. PMID: 25876644
Study Type : Human: Case Report
Additional Links
Additional Keywords : Risk Factors
Anti Therapeutic Actions : Vaccination: Influenza
Problem Substances : Aspartame, Formaldehyde, Thimerosal
[+]
Pubmed Data : Horm Metab Res. 1987 Jul;19(7):285-9. PMID: 2887503
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium
[+]
Pubmed Data : Horm Metab Res. 1987 Jun;19(6):233-8. PMID: 2887500
Study Type : Animal Study
Additional Links
Diseases : Hyperinsulinism
Problem Substances : Acesulfame potassium
[+]
Pubmed Data : Sci Total Environ. 2022 Jul 10 ;829:154689. Epub 2022 Mar 18. PMID: 35314215
Study Type : Animal Study
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Coll Physicians Surg Pak. 2019 Sep ;29(9):848-851. PMID: 31455480
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Sucralose (aka Splenda)
[+]
Pubmed Data : Endocrinol Nutr. 2015 Mar ;62(3):114-22. Epub 2015 Feb 11. PMID: 25681123
Study Type : Animal Study
Additional Links
Additional Keywords : Cytokines
Problem Substances : Aspartame
Adverse Pharmacological Actions : Immunoreactive, Oxidant
[+]
Pubmed Data : Am J Ind Med. 2010 Sep 30. Epub 2010 Sep 30. PMID: 20886530
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]
Pubmed Data : In Vivo. 2007 Jan-Feb;21(1):89-92. PMID: 17354619
Study Type : Animal Study
Additional Links
Diseases : Cancers: All
Problem Substances : Aspartame
[+]
Pubmed Data : Int J Immunopathol Pharmacol. 2015 Jun ;28(2):247-55. Epub 2015 May 26. PMID: 26015492
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Hepatotoxic
[+]
Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance, Neurotoxic
[+]
Pubmed Data : Life Sci. 1998;63(5):337-49. PMID: 9714421
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Nutr Metab (Lond). 2012 Jun 14 ;9(1):58. Epub 2012 Jun 14. PMID: 22697049
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Diabetogenic, Endocrine Disruptor: Insulin Resistance
[+]
Pubmed Data : Ann Anat. 2019 Jul ;224:133-141. Epub 2019 May 18. PMID: 31108189
Study Type : Animal Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(10):e109841. Epub 2014 Oct 14. PMID: 25313461
Study Type : Animal Study
Additional Links
Additional Keywords : Increased Risk, Microbiota
Problem Substances : Aspartame
[+]
Pubmed Data : J Chem Neuroanat. 2016 Aug 24 ;78:42-56. Epub 2016 Aug 24. PMID: 27565676
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Food Chem Toxicol. 2008 Jun;46(6):2074-9. Epub 2008 Feb 8. PMID: 18343556
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2006 Mar;114(3):379-85. PMID: 16507461
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]
Pubmed Data : Food Chem Toxicol. 2007 Dec;45(12):2397-401. Epub 2007 Jun 16. PMID: 17673349
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Aug 6. Epub 2015 Aug 6. PMID: 26247507
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Reprod Biol Endocrinol. 2023 Aug 14 ;21(1):73. Epub 2023 Aug 14. PMID: 37580716
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Cell Biol Toxicol. 2002;18(1):43-50. PMID: 11991085
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Formate
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Physiol Nutr Metab. 2016 Nov 18:1-7. Epub 2016 Nov 18. PMID: 27997218
Study Type : Animal Study
Additional Links
Problem Substances : Artificial Sweeteners, Aspartame
Adverse Pharmacological Actions : Obesogenic
[+]
Pubmed Data : Ann N Y Acad Sci. 2006 Sep;1076:559-77. PMID: 17119233
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Metab Brain Dis. 2018 Sep 28. Epub 2018 Sep 28. PMID: 30264280
Study Type : Animal Study
Additional Links
Problem Substances : Acesulfame potassium , Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Behav Brain Res. 2023 Sep 13 ;453:114615. Epub 2023 Aug 7. PMID: 37558167
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Memory Disorders
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Arch Oral Biol. 2013 Sep ;58(9):1116-22. Epub 2013 Apr 28. PMID: 23631998
Study Type : Animal Study
Additional Links
Diseases : Dental Caries
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2017 Feb 1 ;11:701-707. Epub 2017 Feb 1. PMID: 28187322
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Toxicol Lett. 2019 Sep 12. Epub 2019 Sep 12. PMID: 31521832
Study Type : Animal Study
Additional Links
Additional Keywords : Increased Risk, Synergistic Toxicity
Adverse Pharmacological Actions : Genotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Brain. 2023 ;4:100090. Epub 2023 Jul 30. PMID: 37559954
Study Type : Insect Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Environ Sci Pollut Res Int. 2019 Feb ;26(5):5054-5064. Epub 2019 Jan 3. PMID: 30607847
Study Type : Animal Study
[+]
Pubmed Data : Arch Physiol Biochem. 2017 Nov 2:1-8. Epub 2017 Nov 2. PMID: 29096532
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nat Commun. 2017 Nov 27 ;8(1):1803. Epub 2017 Nov 27. PMID: 29180783
Study Type : Insect Study
Additional Links
Problem Substances : Artificial Sweeteners
[+]
Pubmed Data : Environ Toxicol. 2021 Feb ;36(2):223-237. Epub 2020 Sep 20. PMID: 32951320
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2007 ;2(8):e698. Epub 2007 Aug 1. PMID: 17668074
Study Type : Animal Study
Additional Links
Problem Substances : Saccharin
[+]
Pubmed Data : Morphologie. 2018 Aug 2. Epub 2018 Aug 2. PMID: 30078469
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Hepatotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2023 Aug 31 ;13(1):14326. Epub 2023 Aug 31. PMID: 37652922
Study Type : Animal Study
Additional Links
Diseases : Memory Disorders
Additional Keywords : Transgenerational inheritance
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2007 Sep;115(9):1293-7. PMID: 17805418
Study Type : Animal Study
Additional Links
Diseases : Leukemia, Lymphoma
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]
Pubmed Data : Food Chem Toxicol. 2011 Jun ;49(6):1203-7. Epub 2011 Mar 3. PMID: 21376768
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Glutathione Down-Regulation, Hepatotoxic, Oxidant
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biology (Basel). 2021 Jan 22 ;10(2). Epub 2021 Jan 22. PMID: 33499218
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : J Biochem Mol Toxicol. 2018 Apr 16:e22053. Epub 2018 Apr 16. PMID: 29660801
Study Type : Animal Study
Additional Links
Problem Substances : Artificial Sweeteners
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Nutr Res. 2017 Apr 19. Epub 2017 Apr 19. PMID: 28465000
Study Type : Animal Study
[+]
Pubmed Data : J Med Food. 2021 Feb 10. Epub 2021 Feb 10. PMID: 33570459
Study Type : Animal Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
[+]
Pubmed Data : Ultrastruct Pathol. 2018 May-Jun;42(3):228-245. Epub 2018 Feb 26. PMID: 29482444
Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]
Pubmed Data : Nutrition. 2016 Mar 26. Epub 2016 Mar 26. PMID: 27189909
Study Type : Animal Study
Additional Links
Problem Substances : Artificial Sweeteners, Saccharin
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Microbes. 2023 ;15(1):2157698. PMID: 36524841
Study Type : Animal Study
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 May 25 ;15(11). Epub 2023 May 25. PMID: 37299435
Study Type : Animal Study
Additional Links
Additional Keywords : Metformin
Problem Substances : High Fructose Corn Syrup, Saccharin
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(7):e0199080. Epub 2018 Jul 5. PMID: 29975731
Study Type : Animal Study
Additional Links
Diseases : Dysbiosis
Additional Keywords : Microbiota
[+]
Pubmed Data : Anat Rec (Hoboken). 2016 Dec 20. Epub 2016 Dec 20. PMID: 27998013
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]
Pubmed Data : Neurobiol Learn Mem. 2016 Dec 31 ;139:76-88. Epub 2016 Dec 31. PMID: 28049023
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Food Chem Toxicol. 2023 Aug ;178:113931. Epub 2023 Jul 11. PMID: 37437708
Study Type : Animal Study
Additional Links
Diseases : Inflammation
Problem Substances : Aspartame
Adverse Pharmacological Actions : Inflammatory
[+]
Pubmed Data : Ultrastruct Pathol. 2014 May ;38(3):224-36. Epub 2014 Mar 31. PMID: 24684500
Study Type : Animal Study
Additional Links
Substances : Anise
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Essential Oils
Problem Substances : Aspartame
[+]
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Diabetogenic, Obesogenic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2013 Jun 19 ;10(1):44. Epub 2013 Jun 19. PMID: 23783067
Study Type : Transgenic Animal Study
Additional Links
Diseases : Prediabetes
Adverse Pharmacological Actions : Diabetogenic
[+]
Pubmed Data : J Food Sci. 2023 Apr ;88(4):1731-1742. Epub 2023 Feb 15. PMID: 36789859
Study Type : Animal Study
Additional Links
Problem Substances : Aflatoxin, Aspartame
[+]
Pubmed Data : Appetite. 2012 Oct 19. Epub 2012 Oct 19. PMID: 23088901
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame, Saccharin
[+]
Pubmed Data : Int J Environ Health Res. 2020 Jul 23:1-20. Epub 2020 Jul 23. PMID: 32705899
Study Type : Animal Study
Additional Links
Substances : Seaweed
Diseases : Inflammation
Problem Substances : Aspartame
[+]
Pubmed Data : Pathophysiology. 2017 Feb 15. Epub 2017 Feb 15. PMID: 28254270
Study Type : Animal Study
Additional Links
Substances : Silymarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Aspartame
[+]
Pubmed Data : Metab Brain Dis. 2017 Jun 28. Epub 2017 Jun 28. PMID: 28660358
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Int J Occup Environ Health. 2016 Jan ;22(1):7-17. Epub 2016 Jan 29. PMID: 27078173
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Carcinogenic
[+]
Pubmed Data : Food Chem Toxicol. 1990 Jun;28(6):449-55. PMID: 2210518
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : Food Funct. 2021 Oct 4 ;12(19):9380-9390. Epub 2021 Oct 4. PMID: 34606537
Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Gastrotoxic
[+]
Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S71-89. PMID: 10882819
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : PLoS One. 2014 ;9(4):e92771. Epub 2014 Apr 3. PMID: 24699280
Study Type : Insect Study
Additional Links
Additional Keywords : Lipid Peroxidation, Splenda, Sucralose
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Neurotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Nutr. 2016 Dec 31. Epub 2016 Dec 31. PMID: 28040879
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid, Neurotoxic
[+]
Pubmed Data : Cell Metab. 2016 Jul 12 ;24(1):75-90. PMID: 27411010
Study Type : Animal Study
Additional Links
Diseases : Eating Disorders
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : Food Chem Toxicol. 2000;38 Suppl 2:S53-69. PMID: 10882818
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : Chemosphere. 2012 Jan ;86(1):50-5. Epub 2011 Sep 28. PMID: 21955350
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : J Toxicol Environ Health A. 2018 Aug 21:1-11. Epub 2018 Aug 21. PMID: 30130461
Study Type : Animal Study
Additional Links
Additional Keywords : Bioaccumulation
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : J Toxicol Environ Health A. 2008;71(21):1415-29. PMID: 18800291
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(6):e0178426. Epub 2017 Jun 8. PMID: 28594855
Study Type : Animal Study
Additional Links
Additional Keywords : Microbiome
[+]
Pubmed Data : Brain Res. 2018 12 1 ;1700:181-189. Epub 2018 Sep 7. PMID: 30201258
Study Type : Animal Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Inflamm Bowel Dis. 2018 Mar 15. Epub 2018 Mar 15. PMID: 29554272
Study Type : Animal Study
Additional Links
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2023 Nov ;9(11):e21693. Epub 2023 Nov 3. PMID: 38027700
Study Type : Animal Study
Additional Links
Substances : Bitter Melon, Turmeric
Diseases : Memory Disorders
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]
Pubmed Data : Int J Impot Res. 2017 Apr 27. Epub 2017 Apr 27. PMID: 28446800
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Food Drug Anal. 2018 Apr ;26(2):903-916. Epub 2017 Dec 6. PMID: 29567262
Study Type : Animal Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biosci. 2014 Dec ;39(5):859-66. PMID: 25431414
Study Type : Animal Study
Additional Links
Additional Keywords : Increased Risk
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]
Pubmed Data : ACS Nano. 2019 May 28 ;13(5):6033-6049. Epub 2019 May 6. PMID: 31021591
Study Type : Animal Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : Environ Sci Technol. 2014 Dec 2 ;48(23):13668-74. Epub 2014 Nov 14. PMID: 25365516
Study Type : Environmental
Additional Links
Additional Keywords : Environmental Pollutant
[+]
Pubmed Data : Proc Natl Acad Sci U S A. 2007 Sep 18 ;104(38):15075-80. Epub 2007 Aug 27. PMID: 17724332
Study Type : Animal Study
Additional Links
Additional Keywords : Cephalic Phase Effect
[+]
Pubmed Data : Acta Histochem. 2017 Nov 21. Epub 2017 Nov 21. PMID: 29169694
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Aspartame
[+]
Pubmed Data : Int J Occup Environ Health. 2010 Jan-Mar;16(1):89-96. PMID: 20166324
Study Type : Commentary
Additional Links
Problem Substances : Acesulfame potassium
[+]
Pubmed Data : Food Chem Toxicol. 1997 Dec;35(12):1177-9. PMID: 9449223
Study Type : In Vitro Study
Additional Links
Problem Substances : Acesulfame potassium
[+]
Pubmed Data : Environ Sci Technol. 2023 Aug 1 ;57(30):10919-10928. Epub 2023 Jul 20. PMID: 37475130
Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-Bacterial Agents
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Mar 18 ;15(6). Epub 2023 Mar 18. PMID: 36986196
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Oxidant
[+]
Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Study Type : In Vitro Study
[+]
Pubmed Data : Med Hypotheses. 2010 Mar;74(3):493-6. Epub 2009 Nov 5. PMID: 19896282
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Dermatitis. 2008 May-Jun;19(3):E10-1. PMID: 18627677
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Eur J Clin Nutr. 2008 Apr;62(4):451-62. Epub 2007 Aug 8. PMID: 17684524
Study Type : Review
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Nutr Neurosci. 2017 Feb 15:1-11. Epub 2017 Feb 15. PMID: 28198207
Study Type : Review
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Neurotoxic
[+]
Pubmed Data : Pharmacol Res. 2006 Jan;53(1):1-5. Epub 2005 Aug 29. PMID: 16129618
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Aug 18 ;15(16). Epub 2023 Aug 18. PMID: 37630817
Study Type : Review
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2016 Jul ;23(4):503-6. Epub 2015 Jun 15. PMID: 27298583
Study Type : In Vitro Study
Additional Links
Diseases : Cervical Cancer
Additional Keywords : Disease Progression, Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : Nutr Neurosci. 2023 Jul 3:1-14. Epub 2023 Jul 3. PMID: 37395401
Study Type : Review
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Drug Chem Toxicol. 2008;31(4):447-57. PMID: 18850355
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Technol. 2023 Jan 10 ;57(3):1332-41. Epub 2023 Jan 10. PMID: 36628463
Study Type : In Vitro Study
[+]
Pubmed Data : Int J Occup Environ Health. 2007 Oct-Dec;13(4):446-8. PMID: 18085058
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : Rev Endocr Metab Disord. 2016 Jul 7. Epub 2016 Jul 7. PMID: 27387506
Study Type : Review
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Public Health. 2019 ;77:34. Epub 2019 Jul 15. PMID: 31338189
Study Type : Commentary
Additional Links
Problem Substances : Aspartame
[+]
Pubmed Data : J Pharmacol Sci. 2003 Jan;91(1):83-6. PMID: 12686735
Study Type : In Vitro Study
Additional Links
Problem Substances : Aspartame, Formaldehyde, Methanol
[+]
Pubmed Data : Can J Gastroenterol. 2011 Sep ;25(9):511. PMID: 21912763
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
[+]
Pubmed Data : Mol Cells. 2011 May ;31(5):461-70. Epub 2011 Apr 21. PMID: 21533907
Study Type : In Vitro Study
Additional Links
[+]
Pubmed Data : Iran J Kidney Dis. 2017 Oct ;11(5):339-343. PMID: 29038387
Study Type : Review
Additional Links
Substances : aspartame
Diseases : Kidney Diseases
Additional Keywords : aspartame, Kidney Diseases
Problem Substances : Aspartame
Adverse Pharmacological Actions : Hepatotoxic, Renotoxic
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2023 ;10:1266918. Epub 2023 Dec 8. PMID: 38143439
Study Type : Review
Additional Links
Problem Substances : Aspartame
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Sep 25 ;23(10). Epub 2018 Sep 25. PMID: 30257473
Study Type : In Vitro Study
Additional Links
Additional Keywords : Microbiome
[+]
Pubmed Data : J Hazard Mater. 2022 Apr 4 ;433:128840. Epub 2022 Apr 4. PMID: 35398799
Study Type : In Vitro Study
[+]
Pubmed Data : Ecotoxicol Environ Saf. 2019 Apr 15 ;170:699-707. Epub 2018 Dec 20. PMID: 30580164
Study Type : Review
Additional Links
Additional Keywords : Environmental Pollution
Problem Substances : Artificial Sweeteners
[+]
Pubmed Data : Biofactors. 2017 Sep 7. Epub 2017 Sep 7. PMID: 28881099
Study Type : In Vitro Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : DNA damage
Pharmacological Actions : Renoprotective
Problem Substances : Aspartame
[+]
Pubmed Data : Proc Nutr Soc. 2018 Dec 3:1-10. Epub 2018 Dec 3. PMID: 30501650
Study Type : Review
Additional Links
Diseases : High Sugar Diet
Additional Keywords : Risk Factors
Problem Substances : Artificial Sweeteners
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mayo Clin Proc. 2015 Mar ;90(3):372-81. Epub 2015 Jan 29. PMID: 25639270
Study Type : Review
[+]
Pubmed Data : Food Funct. 2018 Jun 25. Epub 2018 Jun 25. PMID: 29938270
Study Type : In Vitro Study
Additional Links
Problem Substances : Artificial Sweeteners, Saccharin
Adverse Pharmacological Actions : Gastrotoxic
[+]
Pubmed Data : Food Res Int. 2023 Nov ;173(Pt 1):113365. Epub 2023 Aug 7. PMID: 37803662
Study Type : Review
Additional Links
Problem Substances : Artificial Sweeteners, Aspartame
[+]
Pubmed Data : Drug Chem Toxicol. 2015 ;38(3):318-27. Epub 2014 Oct 15. PMID: 25317478
Study Type : In Vitro Study
Additional Links
Additional Keywords : Increased Risk
[+]
Pubmed Data : World J Gastroenterol. 2012 Apr 21 ;18(15):1708-22. PMID: 22553395
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
Adverse Pharmacological Actions : Inflammatory
[+]
Pubmed Data : Chem Res Toxicol. 2019 Jun 17 ;32(6):1241-1249. Epub 2019 May 23. PMID: 31079450
Study Type : In Vitro Study
Additional Links
[+]
Pubmed Data : Environ Sci Technol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21879743
Study Type : Review
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : Environ Sci Technol. 2011 Jan 14. [Epub ahead of print]. PMID: 21235203
Study Type : In Vitro Study
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : Headache. 2006 Sep;46(8):1303-4. PMID: 16942478
Study Type : Commentary
Additional Links
Problem Substances : Sucralose (aka Splenda)
[+]
Pubmed Data : Physiol Behav. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090230
Study Type : Bacterial
Additional Links
Additional Keywords : Microbiota, Risk Factors
[+]
Pubmed Data : Cell Signal. 1998 Nov;10(10):727-33. PMID: 9884024
Study Type : In Vitro Study
Additional Links
Diseases : Hyperinsulinism
[+]
Pubmed Data : Biomarkers. 2006 Jan-Feb;11(1):14-27. PMID: 16484134
Study Type : Commentary
Additional Links
Problem Substances : Aspartame, Benzene
[+]
Pubmed Data : Nicotine Tob Res. 2016 May 23. Epub 2016 May 23. PMID: 27217475
Study Type : In Vitro Study
Additional Links
Additional Keywords : Risk Factors
[+]
Pubmed Data : Curr Diabetes Rev. 2017 May 31. Epub 2017 May 31. PMID: 28571543
Study Type : Review
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Aspartame
[+]
Pubmed Data : Folia Neuropathol. 2013 ;51(1):10-7. PMID: 23553132
Study Type : Review
Additional Links
Problem Substances : Aspartame
Adverse Pharmacological Actions : Carcinogenic
[+]
Pubmed Data : Mutat Res. 2002 Aug 26;519(1-2):103-19. PMID: 12160896
Study Type : In Vitro Study

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Promoted for decades as a "safe" sugar alternative, presumably to prevent or reduce symptoms of diabetes, Splenda (sucralose) has been found to have diabetes-promoting effects in human subjects.
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Synthetic sweeteners have been linked to a wide range of health problems, with over 80 documented on the GreenMedInfo database, alone. The various mechanisms of their toxicity, however, have not yet been fully elucidated. A new study raises a disturbing possibility that these widely consumed chemicals are driving otherwise 'good bacteria' into developing potentially lethal antibiotic resistance through a gut-mediated process.
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