Irinotecan

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11 Diseases Researched for Irinotecan

Name	AC	CK
Gastric Cancer	2	20
Chemotherapy-Induced Toxicity: Irinotecan	6	12
Cancer Metastasis	1	10
Colorectal Cancer	1	10
Colitis	1	2
Drug-Induced Toxicity: Gastrointestinal	1	2
Mucositis	1	2
Nonalcoholic fatty liver disease (NAFLD)	1	2
Testicular Injury: Chemical/Metal Induced	1	2
Fatty Liver	1	1
Liver Damage: Drug-Induced	1	1

Research Articles 10
Cumulative Knowledge Score 16
Overall Research Rating GOOD

View the Evidence:
10 Abstracts with Irinotecan Research

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Biweekly oxaliplatin and irinotecan chemotherapy in advanced gastric cancer results in a median overall survival time of 9.5 months.Sep 01, 2008

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Pubmed Data : Anticancer Res. 2008 Sep-Oct;28(5B):2901-5. PMID: 19031932

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Diseases : Gastric Cancer

Anti Therapeutic Actions : Chemotherapy

Problem Substances : Chemotherapy, Irinotecan, Oxaliplatin

[+]

Irinotecan may be linked to an increased risk of hepatic failure and postoperative death. May 01, 2010

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Pubmed Data : Bull Cancer. 2010 May;97(5):559-69. PMID: 20167564

Article Published Date : May 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cancer Metastasis, Colorectal Cancer

Problem Substances : Irinotecan

[+]

The median overall survival time for oxaliplatin, irinotecan and cetuximab treatment in advanced gastric cancer is survival was 38.1 weeks.Dec 01, 2011

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Pubmed Data : Anticancer Res. 2011 Dec ;31(12):4439-43. PMID: 22199312

Article Published Date : Dec 01, 2011

Study Type : Human Study

Additional Links

Diseases : Gastric Cancer

Anti Therapeutic Actions : Chemotherapy

Problem Substances : Cetuximab , Chemotherapy, Irinotecan, Oxaliplatin

[+]

Curcumin protects against testis-specific side effects of irinotecan.Nov 30, 2021

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2021 Dec ;25(23):7440-7448. PMID: 34919246

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Chemoprotective Agents

Problem Substances : Irinotecan

[+]

Investigation of the possible protective effect of N-Acetylcysteine (NAC) against irinotecan (CPT-11)-induced toxicity.Nov 09, 2022

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Pubmed Data : Antioxidants (Basel). 2022 Nov 10 ;11(11). Epub 2022 Nov 10. PMID: 36421407

Article Published Date : Nov 09, 2022

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents

Problem Substances : Irinotecan

[+]

Luteolin prevents intestinal mucositis induced by irinotecan.Jan 23, 2020

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Pubmed Data : Br J Pharmacol. 2020 Jan 24. Epub 2020 Jan 24. PMID: 31976547

Article Published Date : Jan 23, 2020

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Drug-Induced Toxicity: Gastrointestinal, Mucositis

Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Gastroprotective, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Irinotecan

[+]

Selenium-enriched Bifidobacterium longum DD98 attenuates irinotecan-induced intestinal and hepatic toxicity in vitro and in vivo.Oct 31, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2021 Nov ;143:112192. Epub 2021 Sep 25. PMID: 34649340

Article Published Date : Oct 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bifidobacterium Longum , Selenium

Diseases : Chemotherapy-Induced Toxicity: Irinotecan

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Irinotecan

[+]

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

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Pubmed Data : Toxicol Appl Pharmacol. 2017 Apr 25. Epub 2017 Apr 25. PMID: 28454924

Article Published Date : Apr 24, 2017

Study Type : Animal Study

Additional Links

Substances : Silymarin

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Chemoprotective Agents, Hepatoprotective

Problem Substances : Irinotecan

[+]

Total flavonoids of glycyrrhiza uralensis alleviates irinotecan-induced colitis.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Immunol. 2021 ;12:628358. Epub 2021 May 7. PMID: 34025639

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Irinotecan, Colitis

Pharmacological Actions : Gastrointestinal Agents, Gastroprotective

Problem Substances : Irinotecan

[+]

Drugs like amiodarone, tamoxifen, irinotecan, methotrexate, valproic acid and glucocorticoids have been recognized to be associated with steatosis.Feb 28, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2017 Mar ;21(1 Suppl):86-94. PMID: 28379591

Article Published Date : Feb 28, 2017

Study Type : Review

Additional Links

Diseases : Fatty Liver, Liver Damage: Drug-Induced

Additional Keywords : Risk Factors

Problem Substances : Amiodarone, Irinotecan, Methotrexate, Tamoxifen

Research Articles 10
Cumulative Knowledge Score 16
Overall Research Rating GOOD

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 10 Abstracts with Irinotecan Research

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Currently Available Sorting Options

Biweekly oxaliplatin and irinotecan chemotherapy in advanced gastric cancer results in a median overall survival time of 9.5 months.Sep 01, 2008

Irinotecan may be linked to an increased risk of hepatic failure and postoperative death. May 01, 2010

The median overall survival time for oxaliplatin, irinotecan and cetuximab treatment in advanced gastric cancer is survival was 38.1 weeks.Dec 01, 2011

Curcumin protects against testis-specific side effects of irinotecan.Nov 30, 2021

Investigation of the possible protective effect of N-Acetylcysteine (NAC) against irinotecan (CPT-11)-induced toxicity.Nov 09, 2022

Luteolin prevents intestinal mucositis induced by irinotecan.Jan 23, 2020

Selenium-enriched Bifidobacterium longum DD98 attenuates irinotecan-induced intestinal and hepatic toxicity in vitro and in vivo.Oct 31, 2021

Silymarin showed a dual effect on liver damage induced by irinotecan.Apr 24, 2017

Total flavonoids of glycyrrhiza uralensis alleviates irinotecan-induced colitis.Dec 31, 2020

Drugs like amiodarone, tamoxifen, irinotecan, methotrexate, valproic acid and glucocorticoids have been recognized to be associated with steatosis.Feb 28, 2017

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Irinotecan

View the Evidence:
10 Abstracts with Irinotecan Research