Rotenone

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12 Diseases Researched for Rotenone
NameACCKFocus
Parkinson's Disease2239Locked
Oxidative Stress711Locked
Brain: Oxidative Stress35Locked
Neurodegenerative Diseases24Locked
Chemically-Induced Liver Damage12Locked
Cognitive Decline/Dysfunction12Locked
DNA damage12Locked
Mitochondrial Dysfunction 12Locked
Pesticide Toxicity 22Locked
Testicular Injury: Chemical/Metal Induced12Locked
Inflammation11Locked
Lipid Peroxidation11Locked
1 Adverse Pharmacological Actions Researched for Rotenone
NameACCKFocus
Neurotoxic11Locked

View the Evidence:
32 Abstracts with Rotenone Research

[+]

Amurensin G induces autophagy and attenuates cellular toxicities in a rotenone model of Parkinson's disease.Mar 28, 2013

Pubmed Data : Biochem Biophys Res Commun. 2013 Mar 29 ;433(1):121-6. Epub 2013 Feb 26. PMID: 23485458
Article Published Date : Mar 28, 2013
Study Type : Human In Vitro
Additional Links
Substances : Amurensin G
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Phytotherapy
Problem Substances : Rotenone
[+]

Ellagic acid protects dopamine neurons from rotenone-induced neurotoxicity via activation of Nrf2 signalling Jul 11, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2020 Jul 12. Epub 2020 Jul 12. PMID: 32657027
Article Published Date : Jul 11, 2020
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, Nrf2 activation
Problem Substances : Rotenone
[+]

Ameliorative effect of quercetin, catechin, and taxifolin on rotenone-induced testicular and splenic weight gain and oxidative stress.Jan 14, 2020

Pubmed Data : J Basic Clin Physiol Pharmacol. 2020 Jan 15 ;31(3). Epub 2020 Jan 15. PMID: 31940286
Article Published Date : Jan 14, 2020
Study Type : Animal Study
Additional Links
Substances : Catechin , Flavonoids, Quercetin
Diseases : Oxidative Stress, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants
Problem Substances : Rotenone
[+]

Beneficial effect of rice bran extract against rotenone-induced experimental Parkinson's disease.Jan 24, 2021

Pubmed Data : Curr Mol Pharmacol. 2021 Jan 25. Epub 2021 Jan 25. PMID: 33573588
Article Published Date : Jan 24, 2021
Study Type : Animal Study
Additional Links
Substances : Rice Bran
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Crocin showed promising neuroprotective effects in rotenone-induced Parkinson's disease.Dec 03, 2019

Pubmed Data : Neuropharmacology. 2019 Dec 4:107900. Epub 2019 Dec 4. PMID: 31811872
Article Published Date : Dec 03, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Parkinson's Disease
Pharmacological Actions : MicroRNA modulator, Neuroprotective Agents
Problem Substances : Rotenone
[+]

Demethoxycurcumin ameliorates rotenone-induced toxicity.Dec 31, 2018

Pubmed Data : Front Biosci (Elite Ed). 2019 01 1 ;11:1-11. Epub 2019 Jan 1. PMID: 30468633
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Fisetin may improve the mitochondrial enzyme activity, thereby preventing the pathogenesis of Parkinson's disease.Jan 28, 2020

Pubmed Data : J Diet Suppl. 2020 Jan 29:1-15. Epub 2020 Jan 29. PMID: 31992104
Article Published Date : Jan 28, 2020
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Cognitive Decline/Dysfunction, Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Rotenone
[+]

Icariin protects rotenone-induced neurotoxicity through induction of SIRT3.Jan 14, 2019

Pubmed Data : Toxicol Appl Pharmacol. 2019 09 15 ;379:114639. Epub 2019 Jun 25. PMID: 31251943
Article Published Date : Jan 14, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Neurodegenerative Diseases, Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Rotenone
[+]

Magnolol as a protective antioxidant alleviates rotenone-induced oxidative stress and liver damage.Jan 03, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Metabolites. 2023 Jan 4 ;13(1). Epub 2023 Jan 4. PMID: 36677009
Article Published Date : Jan 03, 2023
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Rotenone
[+]

Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos.Nov 26, 2019

Pubmed Data : J Pineal Res. 2019 Nov 27:e12627. Epub 2019 Nov 27. PMID: 31773776
Article Published Date : Nov 26, 2019
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Mitochondrial Dysfunction
Pharmacological Actions : Cytoprotective
Problem Substances : Rotenone
[+]

Naringin could be an alternative option in the management of Parkinson's disease.Jan 07, 2020

Pubmed Data : Neuromolecular Med. 2020 Jan 8. Epub 2020 Jan 8. PMID: 31916219
Article Published Date : Jan 07, 2020
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism.May 14, 2018

Pubmed Data : Phytomedicine. 2018 May 15 ;44:65-73. Epub 2018 Apr 16. PMID: 29895494
Article Published Date : May 14, 2018
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Rotenone
[+]

Neuroprotective effects of mitochondria-targeted curcumin against rotenone-induced oxidative damage in cerebellum.Dec 31, 2019

Pubmed Data : J Biochem Mol Toxicol. 2020 Jan ;34(1):e22416. Epub 2019 Nov 12. PMID: 31714633
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Problem Substances : Rotenone
[+]

Present findings show that pistachio possesses neuroprotective effects and improves memory and motor deficits.Jun 10, 2020

Pubmed Data : Metab Brain Dis. 2020 Jun 11. Epub 2020 Jun 11. PMID: 32529399
Article Published Date : Jun 10, 2020
Study Type : Animal Study
Additional Links
Substances : Pistachio nut
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Problem Substances : Rotenone
[+]

Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease.Sep 30, 2022

Pubmed Data : Neuropharmacology. 2022 Oct 1 ;217:109209. Epub 2022 Aug 5. PMID: 35940347
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Safflower
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Additional Keywords : Plant Extracts
Problem Substances : Rotenone
[+]

Prophylactic neuroprotective propensity of crocin against rotenone induced neurotoxicity.Jun 17, 2019

Pubmed Data : Metab Brain Dis. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31214956
Article Published Date : Jun 17, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson's disease.Jan 17, 2020

Pubmed Data : Neurosci Lett. 2020 Jan 18 ;716:134652. Epub 2019 Nov 25. PMID: 31778768
Article Published Date : Jan 17, 2020
Study Type : Animal Study
Additional Links
Substances : Mangosteen
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Resveratrol can elicit neuroprotective effects on rotenone-induced parkinsonism.May 02, 2017

Pubmed Data : Neuroreport. 2017 May 3. Epub 2017 May 3. PMID: 28471847
Article Published Date : May 02, 2017
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Sodium fluoride and rotenone may interact synergistically leading to oxidative damage and neuronal cell loss.Oct 31, 2023

Pubmed Data : Neurol Res. 2023 Nov ;45(11):979-987. Epub 2023 Sep 12. PMID: 37699078
Article Published Date : Oct 31, 2023
Study Type : Animal Study
Additional Links
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants
Additional Keywords : Synergistic Toxicity
Problem Substances : Rotenone, Sodium Fluoride
[+]

The protective effect of biochanin A against rotenone-induced neurotoxicit.Nov 30, 2020

Pubmed Data : Ecotoxicol Environ Saf. 2020 Dec 1 ;205:111344. Epub 2020 Sep 22. PMID: 32977283
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Brain: Oxidative Stress, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Problem Substances : Rotenone
[+]

This evidence provides a potential clinically relevant role for EGCG in delaying or treating human Parkinson's disease.Dec 05, 2019

Pubmed Data : Neurotox Res. 2019 Dec 6. Epub 2019 Dec 6. PMID: 31811588
Article Published Date : Dec 05, 2019
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents
Problem Substances : Rotenone
[+]

V. officinalis extract was effective in reducing the toxicity induced by rotenone in D. melanogaster.Jun 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurotoxicology. 2013 Jul ;37:118-26. Epub 2013 Apr 29. PMID: 23639798
Article Published Date : Jun 30, 2013
Study Type : Insect Study
Additional Links
Substances : Valerian
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Rotenone
[+]

Antioxidant and cytoprotective effects of avocado oil and extract against rotenone.Jan 01, 2021

Pubmed Data : J Toxicol Environ Health A. 2021 11 2 ;84(21):875-890. Epub 2021 Jul 13. PMID: 34256683
Article Published Date : Jan 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Avocado
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Additional Keywords : Plant Extracts
Problem Substances : Rotenone
[+]

Berberine alleviates rotenone-induced cytotoxicity by antioxidation and activation of PI3K/Akt signaling pathway in SH-SY5Y cells.Oct 29, 2019

Pubmed Data : Neuroreport. 2019 Oct 30. Epub 2019 Oct 30. PMID: 31688419
Article Published Date : Oct 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Cytoprotective
Problem Substances : Rotenone
[+]

Curcumin loaded lactoferrin nanoparticles could be a promising drug delivery strategy against neurotoxicity in dopaminergic neurons.Jan 26, 2016

Pubmed Data : Neurochem Int. 2016 Jan 27. Epub 2016 Jan 27. PMID: 26826319
Article Published Date : Jan 26, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Demethoxycurcumin may serve as a potent therapeutic agent particularly for the treatment of neurodegenerative diseases.Apr 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Apr 18 ;17(1):217. Epub 2017 Apr 18. PMID: 28420370
Article Published Date : Apr 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Parkinson's Disease, Pesticide Toxicity
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Fisetin protects against rotenone-induced neurotoxicity through signaling pathway.Dec 31, 2018

Pubmed Data : Front Biosci (Elite Ed). 2019 01 1 ;11:20-28. Epub 2019 Jan 1. PMID: 30468635
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Lipid Peroxidation, Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Neuroprotective Agents
Problem Substances : Rotenone
[+]

Neuroprotective effects of catechin and quercetin in experimental Parkinsonism.Apr 30, 2022

Pubmed Data : Neurotoxicology. 2022 May ;90:158-171. Epub 2022 Mar 23. PMID: 35337893
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Quercetin
Diseases : Brain: Oxidative Stress, Inflammation, Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Rotenone
[+]

Parkinsonian neurotoxicants impair the anti-inflammatory response induced by IL4 in glial cells.Jun 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Jun 30 ;10(1):10650. Epub 2020 Jun 30. PMID: 32606391
Article Published Date : Jun 29, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Parkinson's Disease, Pesticide Toxicity
Additional Keywords : Risk Factors
Problem Substances : Rotenone
Adverse Pharmacological Actions : Neurotoxic
[+]

The study highlights Yashtimadhu as a promising candidate with neuroprotective effects.Mar 25, 2021

Pubmed Data : J Ethnopharmacol. 2021 Mar 26 ;274:114025. Epub 2021 Mar 26. PMID: 33775804
Article Published Date : Mar 25, 2021
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents
Problem Substances : Rotenone
[+]

Thymoquinone protects dopaminergic neurons against MPP+ and rotenone.Apr 30, 2009

Pubmed Data : Phytother Res. 2009 May ;23(5):696-700. PMID: 19089849
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Parkinson's Disease
Pharmacological Actions : Neuroprotective Agents
Problem Substances : Rotenone
[+]

Water-soluble CoQ10 may have therapeutic potential in treating patients with Parkinson's disease.Mar 31, 2017

Pubmed Data : Neurochem Res. 2017 Apr ;42(4):1096-1103. Epub 2017 Feb 11. PMID: 28190227
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Coenzyme Q10
Diseases : Parkinson's Disease
Problem Substances : Rotenone

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