Sodium hexametaphosphate

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2 Diseases Researched for Sodium hexametaphosphate

Name	AC	CK	Focus
Dermatitis: Contact	1	2
Kidney Damage	1	2

1 Adverse Pharmacological Actions Researched for Sodium hexametaphosphate

Name	AC	CK	Focus
Nephrotoxic	1	2

Research Articles 1
Cumulative Knowledge Score 1
Overall Research Rating GOOD

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1 Abstracts with Sodium hexametaphosphate Research

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Sodium hexametaphosphate is a skin irritant topically and has adverse kidney effects when ingested (10% diet) animal experiments..Jan 01, 2001

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Pubmed Data : Int J Toxicol. 2001;20 Suppl 3:75-89. PMID: 11766135

Article Published Date : Jan 01, 2001

Study Type : Animal Study

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Diseases : Dermatitis: Contact, Kidney Damage

Problem Substances : Sodium hexametaphosphate

Adverse Pharmacological Actions : Nephrotoxic

Research Articles 1
Cumulative Knowledge Score 1
Overall Research Rating GOOD

"SHMP is used as a sequestrant and has applications with in a wide variety of industries, including as a food additive in which it is used under the E number E452i. Sodium carbonate is sometimes added to SHMP to raise the pH to 8.0-8.6, which produces a number of SHMP products used for water softening and detergents. Also used as a dispersing agent to break down clay and other soil types." [ Source: Wikipedia ]

... FEEDING RATS 3% & 5% ... SODIUM HEXAMETAPHOSPHATE RESULTED IN SEVERE KIDNEY DAMAGE, WHILE FEEDING 1.8% ... CAUSED NO OBSERVABLE PHYSIOLOGICAL DAMAGE. ... HOWEVER, WHEN DOGS WERE FED INCREASING DOSAGES ... BEGINNING AT 1.0 G/KG/DAY AND INCREASING TO 4.0 G/KG FOR THE LAST MONTH OF A 5-MONTH FEEDING PERIOD, THE DOGS ... BEGAN TO LOSE WEIGHT WHEN THE DAILY DOSE REACHED 2.5 G/KG/DAY.
[Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 640] **PEER REVIEWED** [ Source: Toxnet ]

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