Synthetic Vitamin A

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Research Articles 14
Cumulative Knowledge Score 22
Overall Research Rating GOOD

View the Evidence:
14 Abstracts with Synthetic Vitamin A Research

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High dietary intake of preformed vitamin A appears to be teratogenic. Among the babies born to women who took more than 10,000 IU of preformed vitamin A per day in the form of supplements, we estimate that about 1 infant in 57 had a malformation attributaNov 23, 1995

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : N Engl J Med. 1995 Nov 23 ;333(21):1369-73. PMID: 7477116

Article Published Date : Nov 23, 1995

Study Type : Human Study

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Substances : Vitamin A

Diseases : Abnormalities, Birth Defects, Drug-Induced, Prenatal Nutrition: Prevention of Problems

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

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"Teratogenic effects of chronic ingestion of high levels of vitamin A (retinyl acetate) in cats."Feb 01, 2003

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Pubmed Data : J Anim Physiol Anim Nutr (Berl). 2003 Feb ;87(1-2):42-51. PMID: 14511148

Article Published Date : Feb 01, 2003

Study Type : Animal Study

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Diseases : Birth Defects

Problem Substances : Retinyl Acetate

Adverse Pharmacological Actions : Teratogenic

[+]

Chronic administration (13 weeks) of vitamin A palmitate resulted in lowered testosterone and morphological changes in the testes of male rats.Sep 01, 1988

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Pubmed Data : Food Chem Toxicol. 1988 Sep;26(9):767-73. PMID: 3209139

Article Published Date : Sep 01, 1988

Study Type : Animal Study

Additional Links

Diseases : Low Testosterone

Problem Substances : Vitamin A palmitate

Adverse Pharmacological Actions : Endocrine Disruptor

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High dose vitamin A palmitate results in fused carpal bone defects in rat fetuses.Jun 01, 2010

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Pubmed Data : Hum Exp Toxicol. 2010 Jun;29(6):439-50. Epub 2010 Mar 17. PMID: 20237176

Article Published Date : Jun 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Prenatal Chemical Exposures

Problem Substances : Vitamin A palmitate

Adverse Pharmacological Actions : Teratogenic

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High doses of vitamin A palmitate produces adverse clinical and biochemical alterations in rats.Sep 01, 2007

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Pubmed Data : Arch Latinoam Nutr. 2007 Sep;57(3):224-30. PMID: 18271400

Article Published Date : Sep 01, 2007

Study Type : Animal Study

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Problem Substances : Vitamin A palmitate

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Low doses of vitamin A (retinyl acetate) result in defects in offspring of animals and perhaps humans when consumed during the early gestational period.Oct 01, 2000

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Pubmed Data : Teratology. 2000 Oct;62(4):214-26. PMID: 10992263

Article Published Date : Oct 01, 2000

Study Type : Animal Study

Additional Links

Diseases : Birth Defects

Problem Substances : Vitamin A acetate

Adverse Pharmacological Actions : Teratogenic

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Retinyl (retinol) palmitate feeding results in abnormal development and abnormalities in the embryos of mice.Apr 01, 2003

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Pubmed Data : Biol Pharm Bull. 2003 Apr;26(4):553-6. PMID: 12673043

Article Published Date : Apr 01, 2003

Study Type : Animal Study

Additional Links

Diseases : Prenatal Chemical Exposures

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Retinyl acetate induces arthritis in mice.May 01, 1989

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Pubmed Data : Arthritis Rheum. 1989 May;32(5):625-33. PMID: 2719733

Article Published Date : May 01, 1989

Study Type : Animal Study

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Diseases : Arthritis

Problem Substances : Vitamin A acetate

Adverse Pharmacological Actions : Inflammatory

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Retinyl palmitate exhibits teratrogenic properties. Dec 01, 2009

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Pubmed Data : Indian J Exp Biol. 2009 Dec ;47(12):949-54. PMID: 20329697

Article Published Date : Dec 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Prenatal Chemical Exposures

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

[+]

Retinyl palmitate induces malformations in the embryos of pregnant rats.Sep 01, 1996

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Pubmed Data : Pharmacol Toxicol. 1996 Sep;79(3):131-5. PMID: 8884871

Article Published Date : Sep 01, 1996

Study Type : Animal Study

Additional Links

Diseases : Birth Defects, Prenatal Chemical Exposures

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Teratogenic

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Synthetic vitamin A induces hemorrhaging and bone toxicity in rats fed a diet deficient in vitamin K. Feb 01, 1989

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Pubmed Data : Toxicol Appl Pharmacol. 1989 Feb;97(2):300-10. PMID: 2922761

Article Published Date : Feb 01, 1989

Study Type : Animal Study

Additional Links

Diseases : Bone Fractures, Vitamin K Deficiency

Problem Substances : 13-cis-retinoic acid , Retinyl Acetate

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Vitamin A acetate be be a teratogenic substance malformation and low oxygen consumption by rat embryos. Jul 01, 1976

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Pubmed Data : Ann Clin Lab Sci. 1976 Jul-Aug;6(4):332-41. PMID: 962297

Article Published Date : Jul 01, 1976

Study Type : Animal Study

Additional Links

Problem Substances : Vitamin A acetate

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Punicalagin could effectively attenuate FFA-induced lipotoxicity by activating Keap1-Nrf2 cytoprotective signaling pathway.Apr 30, 2016

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Pubmed Data : Mol Nutr Food Res. 2016 May ;60(5):1139-49. Epub 2016 Apr 14. PMID: 26989875

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Punicalagin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Nrf2 activation

Problem Substances : Retinyl palmitate

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Retinyl palmitate is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action.Nov 01, 2005

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Pubmed Data : Toxicol Sci. 2005 Nov;88(1):142-9. Epub 2005 Aug 17. PMID: 16107546

Article Published Date : Nov 01, 2005

Study Type : In Vitro Study

Additional Links

Problem Substances : Retinyl palmitate

Adverse Pharmacological Actions : Clastogenic, Mutagenic, Photomutagenic

Research Articles 14
Cumulative Knowledge Score 22
Overall Research Rating GOOD

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Why Is Birth Defect-Linked Vitamin A Used In Prenatals?

Written by Sayer Ji, Founder

A human study published in the New England Journal of Medicine in 1995 showed that women who consumed 10,000 IU of preformed vitamin A from supplements per day had 4.8 times the rate of birth defects than those who consumed 5,000 IU per day while pregnant. The increased frequency of defects was concentrated among babies born to women who consumed high levels of vitamin A before the seventh week of gestation.

Why Is Birth Defect-Linked Vitamin A Used In Prenatals?

Written by Sayer Ji, Founder

Synthetic Forms: Retinyl Acetate, Retinol Acetate, Vitamin A acetate, Vitamin A palmitate, Retinyl palmitate, 13-cis-retinoic acid and Retinoids.

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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The Following are Sub-Topics of Synthetic Vitamin A

View the Evidence: 14 Abstracts with Synthetic Vitamin A Research

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High dietary intake of preformed vitamin A appears to be teratogenic. Among the babies born to women who took more than 10,000 IU of preformed vitamin A per day in the form of supplements, we estimate that about 1 infant in 57 had a malformation attributaNov 23, 1995

"Teratogenic effects of chronic ingestion of high levels of vitamin A (retinyl acetate) in cats."Feb 01, 2003

Chronic administration (13 weeks) of vitamin A palmitate resulted in lowered testosterone and morphological changes in the testes of male rats.Sep 01, 1988

High dose vitamin A palmitate results in fused carpal bone defects in rat fetuses.Jun 01, 2010

High doses of vitamin A palmitate produces adverse clinical and biochemical alterations in rats.Sep 01, 2007

Low doses of vitamin A (retinyl acetate) result in defects in offspring of animals and perhaps humans when consumed during the early gestational period.Oct 01, 2000

Retinyl (retinol) palmitate feeding results in abnormal development and abnormalities in the embryos of mice.Apr 01, 2003

Retinyl acetate induces arthritis in mice.May 01, 1989

Retinyl palmitate exhibits teratrogenic properties. Dec 01, 2009

Retinyl palmitate induces malformations in the embryos of pregnant rats.Sep 01, 1996

Synthetic vitamin A induces hemorrhaging and bone toxicity in rats fed a diet deficient in vitamin K. Feb 01, 1989

Vitamin A acetate be be a teratogenic substance malformation and low oxygen consumption by rat embryos. Jul 01, 1976

Punicalagin could effectively attenuate FFA-induced lipotoxicity by activating Keap1-Nrf2 cytoprotective signaling pathway.Apr 30, 2016

Retinyl palmitate is photomutagenic in combination with UVA exposure in mouse lymphoma cells, with a clastogenic mode-of-action.Nov 01, 2005

Synthetic Vitamin A Related Articles

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Synthetic Vitamin A

View the Evidence:
14 Abstracts with Synthetic Vitamin A Research